Hub : Genes

Tcirg1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000017220	0.16	0.1	8.4e-04	0.01	0.01	0.03	0.01	4.6e-02	6.8e-03	6.5e-04	5.2e-02
2	BLA	gene expression	ENSRNOG00000017220	0.07	0.06	6.5e-03	0.05	0.03	0.04	0.04	1.5e-03	6.3e-03	4.6e-03	4.5e-03
3	LHb	isoform ratio	ENSRNOT00000089107	0.26	0.16	1.0e-03	0.15	0.13	0.04	0.12	2.0e-04	5.1e-04	4.4e-02	1.0e-03
4	Liver	gene expression	ENSRNOG00000017220	0.31	0.13	0.0e+00	0.16	0.16	0.16	0.17	6.8e-18	2.8e-17	2.2e-17	4.3e-18

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
BMI with tail	1.9	6.0	10.9	0.2	2.6	3.3	-2.6
BMI without tail	1.1	2.4	4.2	0.3	1.6	2.1	-1.7
Body weight	2.5	10.8	17.3	2.6	3.8	2.2	-4.2
Epididymis fat weight	2.5	5.8	8.5	-2.3	-2.9	-1.0	2.9
Glucose	1.4	2.2	3.1	-1.8	-1.4	0.9	1.6
Heart weight	1.1	1.6	2.6	-1.2	-1.6	-0.3	1.5
Left kidney weight	0.8	2.4	4.0	-0.7	-2.0	-1.6	1.7
Right kidney weight	0.8	2.2	4.1	-0.2	-1.7	-2.0	1.4
Tail length	0.8	2.5	5.0	2.2	1.3	-0.9	-1.6
Length with tail	2.1	7.7	12.0	3.5	2.9	-0.1	-3.3
Length without tail	1.9	4.2	6.3	2.3	2.3	0.5	-2.5
Liver weight, left	0.1	0.1	0.2	-0.2	-0.4	-0.2	0.5
Liver weight, right	0.2	0.3	0.9	-0.0	-0.4	-0.9	0.3
Parametrial fat weight	1.6	3.1	4.6	-2.1	-1.8	0.3	2.1
Retroperitoneal fat weight	3.9	12.8	19.9	-3.1	-4.5	-1.5	4.4
Intraocular pressure	0.5	0.7	2.2	0.1	-0.5	-1.5	0.7
Extensor digitorum longus weight	5.3	21.1	32.2	4.5	5.7	1.2	-5.5
Soleus weight	3.0	8.8	13.2	-1.6	-3.5	-2.7	3.6
Tibialis anterior weight	7.3	25.3	35.0	5.6	5.9	-0.6	-5.8
Tibia length	0.3	1.0	1.7	1.3	0.4	-1.3	-0.6
Number of licking bursts	0.1	0.1	0.2	-0.5	0.2	0.4	-0.0
Food consumed during 24 hour testing period	0.3	0.4	0.5	-0.4	-0.6	-0.7	0.6
Times rat made contact with spout	0.4	0.5	1.3	-0.3	0.5	1.1	-0.6
Mean time between licks in bursts	0.8	1.1	1.5	1.2	1.1	0.3	-1.2
Mean num. licks in bursts	0.0	0.1	0.1	0.1	-0.2	0.4	-0.1
Std. dev. time between licks in bursts	0.8	0.9	1.2	1.1	1.0	-1.0	-0.7
Water consumed over 24 hours	0.5	0.6	0.9	0.3	0.8	0.9	-0.9
Indifference point 0 sec	0.3	0.5	1.5	-0.2	-1.2	-0.1	0.8
Indifference point AUC	1.2	1.5	2.6	1.1	1.6	-0.2	-1.4
Indifference point function ln k	3.6	5.0	7.6	-2.0	-2.7	-1.1	2.8
Indifference point function log k	3.6	5.0	7.6	-2.0	-2.7	-1.1	2.8
Delay discounting total patch changes 0 sec	0.2	0.3	0.8	0.4	-0.9	-0.5	0.4
Delay discounting total patch changes 12 sec	1.9	2.5	3.9	1.7	1.7	0.5	-2.0
Delay discounting total patch changes 18 sec	0.2	0.3	0.4	0.5	0.6	0.5	-0.6
Delay discounting total patch changes 24 sec	1.0	1.2	2.3	1.5	1.0	-0.3	-1.2
Delay discounting total patch changes 6 sec	0.5	0.8	1.2	0.6	0.6	1.1	-1.1
Delay discounting time to switch 0 sec	1.7	2.6	6.2	0.1	1.5	2.5	-1.5
Delay discounting water rate 0 sec	3.8	6.0	10.4	-0.4	-2.6	-3.2	2.6
Delay discounting water rate 12 sec	5.2	7.8	11.1	-1.1	-3.0	-3.3	3.2
Delay discounting water rate 18 sec	1.3	1.7	2.6	-0.9	-1.4	-1.2	1.6
Delay discounting water rate 24 sec	2.2	3.0	5.9	-0.3	-1.7	-2.4	1.7
Delay discounting water rate 6 sec	1.4	2.0	4.7	0.1	-1.2	-2.2	1.4
Locomotor activity	0.8	1.3	1.8	-0.7	-1.4	-1.1	1.3
Locomotor testing distance	1.0	1.6	2.6	-0.8	-1.6	-1.2	1.4
Locomotor testing rearing	0.9	1.4	2.2	-1.5	-1.2	0.1	1.3
Light reinforcement 1	0.4	0.8	1.0	-0.5	-1.0	-0.9	1.0
Light reinforcement 2	2.0	2.6	3.8	-1.2	-1.9	-1.2	1.9
Reaction time number correct	0.3	0.5	0.8	0.7	0.9	-0.5	-0.6
Reaction time mean minus median	1.2	1.6	2.5	0.4	1.6	1.1	-1.6
Reaction time mean minus median AUC	1.0	1.2	2.4	0.5	1.5	0.4	-1.5
Reaction time num false alarms	0.3	0.4	1.0	0.8	0.1	-1.0	-0.2
Reaction time num false alarms AUC	0.6	0.8	1.4	1.2	0.8	-0.5	-0.9
Reaction time trials correct on left	0.3	0.5	0.8	0.7	0.9	-0.5	-0.6
Reaction time trials on left	0.4	0.6	1.0	0.8	1.0	-0.5	-0.7
Reaction time mean	0.1	0.1	0.3	-0.4	0.1	0.5	0.0
Reaction time mean AUC	0.1	0.2	0.3	-0.5	-0.1	0.6	0.2
Median of all reaction times	0.2	0.2	0.3	-0.6	-0.2	0.6	0.4
Reaction time omissions	1.2	1.6	2.9	0.9	1.7	0.5	-1.6
Reaction time false alarm rate	0.2	0.3	0.6	0.8	0.1	-0.5	-0.4
Reaction time premature initiation rate	1.9	2.5	4.0	1.4	1.9	0.8	-2.0
Reaction time premature initiations	2.9	4.1	6.6	1.9	2.6	0.4	-2.5
Std. dev. reaction times	0.3	0.4	0.6	-0.0	0.7	0.7	-0.7
Reaction time trials completed	0.4	0.6	1.0	0.8	1.0	-0.5	-0.7
Reaction time trials AUC	0.3	0.4	0.7	0.7	0.8	-0.4	-0.6
Social response proportion	0.5	0.6	1.2	0.1	0.8	1.1	-0.7
Social responses	0.3	0.3	0.6	0.6	0.8	-0.2	-0.6
Social time	0.4	0.5	0.8	0.4	0.9	0.4	-0.9
Conditioned locomotion	2.3	2.7	3.5	1.9	1.8	-1.0	-1.7
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.4	-0.5	0.1	0.4
Cocaine response after cond. not corrected	0.3	0.3	0.6	-0.8	-0.4	0.5	0.4
Cocaine response before conditioning	0.1	0.2	0.3	-0.4	0.4	0.5	-0.2
Saline control response	2.2	2.9	4.2	1.5	2.1	0.9	-2.1
Condit. Reinf. active minus inactive responses	1.5	1.8	4.1	-2.0	-1.1	1.0	1.0
Condit. Reinf. active-inactive response ratio	2.4	2.5	4.6	-2.1	-1.7	0.3	1.6
Condit. Reinf. active responses	0.9	1.3	2.5	-1.6	-0.4	1.6	0.3
Condit. Reinf. inactive responses	0.8	1.0	2.2	0.1	1.0	1.5	-1.0
Condit. Reinf. lever presses	0.7	1.0	2.1	-0.5	0.9	1.4	-0.8
Condit. Reinf. lever reinforcers received	0.9	1.2	3.0	-1.4	-0.1	1.7	0.0
Pavlov. Cond. lever latency	0.1	0.1	0.4	0.6	-0.1	-0.3	0.1
Pavlov. Cond. magazine entry latency	2.2	2.6	4.0	0.1	1.8	2.0	-1.8
Pavlov. Cond. change in total contacts	0.4	0.6	1.5	-0.7	0.4	1.2	-0.4
Pavlov. Cond. index score	0.7	0.9	1.5	-0.3	1.1	1.2	-0.9
Pavlov. Cond. latency score	0.5	0.7	1.2	-0.4	0.9	1.1	-0.7
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.3	0.2	-0.2	-0.1
Pavlov. Cond. magazine entry number	2.9	3.6	5.1	-0.3	-2.2	-2.3	2.1
Pavlov. Cond. intertrial magazine entries	1.0	1.3	2.5	-0.2	-1.6	-1.0	1.3
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	1.8	-0.1	1.3	1.3	-1.1
Pavlov. Cond. response bias	0.4	0.6	0.8	-0.3	0.9	0.9	-0.8
Conditioned reinforcement - actives	0.4	0.4	0.9	-0.1	-0.5	-0.9	0.6
Conditioned reinforcement - inactives	4.2	4.7	7.6	-1.7	-2.6	-1.2	2.7
Conditioned locomotion	6.9	8.3	12.0	-1.7	-3.4	-2.6	3.5
Intermittent access intake day 1-15 change	1.4	1.4	2.1	-0.6	-1.4	-1.1	1.4
Intermittent access intake escalation	1.3	1.3	2.1	-0.8	-1.3	-0.8	1.5
Intermittent access intake escalation 2	0.6	0.6	1.0	-0.4	-0.8	-0.8	1.0
Intermitt. access day 1 inactive lever presses	1.2	1.3	2.1	-1.0	-1.4	-0.4	1.4
Intermitt. access day 15 inactive lever presses	1.4	1.6	2.7	-1.1	-1.7	-0.1	1.5
Intermitt. access escalation Index	2.0	1.8	2.9	-0.9	-1.5	-1.1	1.7
Intermittent access day 1 total infusions	2.9	3.3	4.6	-2.2	-2.0	1.3	1.8
Intermittent access day 15 total infusions	5.5	6.2	9.9	-2.4	-3.2	-0.4	3.0
Intermittent access terminal intake (last 3 days)	3.7	4.1	6.7	-2.0	-2.6	0.1	2.4
Intermittent access total infusions	2.3	2.6	3.9	-1.7	-2.0	0.5	1.8
Intermittent access day 1 locomotion	1.4	1.4	2.1	-1.4	-1.1	1.2	0.9
Intermittent access day 15 total locomotion	3.4	3.6	5.6	-1.9	-2.2	-0.4	2.4
Intermittent access total locomotion	4.2	4.7	6.6	-2.5	-2.4	0.5	2.6
Intermittent access standard deviation	0.6	0.6	1.2	-0.4	-1.1	-0.6	1.0
Cocaine induced anxiety	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.2
Post-drug Anxiety	0.8	0.9	1.3	1.1	1.0	-0.2	-1.1
Baseline Anxiety	1.5	1.6	2.4	1.4	1.5	-0.0	-1.5
Lifetime Intake	1.9	2.1	3.3	-1.5	-1.8	0.5	1.6
Incentive Sensitization - Responses	0.2	0.2	0.4	-0.6	-0.5	-0.0	0.6
Incentive Sensitization - Breakpoint	0.4	0.4	0.7	-0.7	-0.7	-0.2	0.8
Progressive ratio test 1 active lever presses	1.1	1.2	2.1	-0.7	-1.4	-0.7	1.2
Progressive ratio test 1 breakpoint	1.0	1.1	2.0	-0.6	-1.4	-0.8	1.1
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.5	-0.4	-0.7	-0.2	0.7
Progressive ratio test 2 active lever presses	2.2	2.3	3.7	-1.3	-1.9	-0.7	1.9
Progressive ratio test 2 breakpoint	2.8	3.1	4.7	-1.2	-2.2	-1.2	2.1
Progressive ratio test 2 inactive lever presses	5.3	6.1	9.5	-2.3	-3.1	-0.6	3.1
Total sessions with >9 infusions	0.4	0.5	0.8	-0.7	-0.9	0.1	0.8
Short access day 1 total inactive lever presses	1.9	2.1	3.7	-1.3	-1.9	-0.4	1.7
Short access day 10 total inactive lever presses	0.9	1.0	1.6	-1.0	-1.2	-0.2	1.2
Short access day 1 total infusions	1.5	1.6	3.1	-1.1	-1.7	0.4	1.3
Short access day 10 total infusions	1.3	1.5	2.8	-1.4	-0.9	1.7	0.6
Short access total infusions	0.6	0.6	0.8	-0.8	-0.9	0.9	0.6
Short access day 1 locomotion	1.2	1.3	1.8	-1.3	-1.4	0.5	1.2
Short access day 10 total locomotion	0.5	0.6	0.9	-0.9	-0.7	0.6	0.7
Short access total locomotion	0.5	0.5	0.7	-0.8	-0.7	0.6	0.5
Compulsive drug intake	2.9	2.9	4.4	1.9	1.9	-0.1	-2.1
One hour access (0.3 mA shock)	5.4	6.3	10.8	-2.0	-3.3	-1.0	3.1
One hour access (shock baseline)	6.4	7.4	11.9	-2.2	-3.4	-1.2	3.4
Number of responses in last shaping day	0.4	0.4	0.5	-0.3	-0.7	-0.6	0.7
Context. condit. distance diff. score	0.8	0.9	1.5	-0.9	-1.2	-0.1	1.2
Locomotion velocity, session 1	0.0	0.0	0.2	-0.4	0.1	0.1	0.1
Locomotion distance, session 1	1.0	1.3	3.1	-1.0	0.8	1.7	-0.5
Locomotion velocity, session 2	1.8	2.1	3.3	1.3	1.8	0.6	-1.8
Locomotion distance, session 2	0.8	1.2	2.0	-0.3	1.4	1.2	-1.1
Locomotion velocity, session 3	0.8	0.9	2.4	-1.1	-0.2	1.5	-0.0
Locomotion distance, session 3	0.0	0.0	0.1	-0.2	0.0	0.4	0.0
Stereotopy head waving bouts, day 3	0.6	0.7	1.5	-0.8	-0.7	1.2	0.5
Stereotopy head waving duration, day 3	0.8	1.0	1.4	-1.1	-1.2	0.6	1.0
Locomotion velocity, session 7	0.4	0.5	1.3	-0.8	0.0	1.2	0.0
Locomotion distance, session 7	0.2	0.3	0.7	-0.0	0.8	0.6	-0.4
Stereotopy head waving bouts, day 7	0.8	0.9	1.1	-1.1	-1.0	1.0	0.6
Stereotopy head waving duration, day 7	0.9	1.1	3.4	-0.2	0.4	1.8	-0.8
Locomotion velocity, session 8	1.0	1.2	1.9	0.9	1.3	0.6	-1.4
Locomotion distance, session 8	0.4	0.6	1.5	-1.2	-0.3	0.5	0.7
Degree of sensitization distance	0.3	0.3	0.5	-0.1	0.7	0.7	-0.4
Degree of sensitization stereotypy	0.3	0.4	1.2	-0.2	0.1	1.1	-0.4
Condit. Reinf. active minus inactive responses	0.2	0.2	0.6	-0.5	0.1	0.8	-0.2
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.6	-0.3	0.5	0.1
Condit. Reinf. active responses	0.0	0.0	0.1	-0.2	-0.0	0.2	-0.1
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.1	-0.2	-0.3	0.2
Incentive salience index mean	0.2	0.2	0.4	-0.4	0.5	0.7	-0.3
Condit. Reinf. lever presses	0.1	0.1	0.4	-0.0	0.6	-0.2	-0.1
Time in familiar zone, hab. session 1	0.5	0.5	0.8	-0.9	-0.7	0.3	0.8
Time in novel zone, hab. session 1	0.1	0.1	0.2	0.4	0.1	-0.2	-0.3
Total zone transitions, hab. session 1	0.4	0.6	1.5	-0.0	1.2	0.7	-0.7
Total locomotion distance, hab. session 1	0.4	0.6	1.3	-1.1	-0.4	0.0	0.9
Locomotion velocity, hab. session 1	0.2	0.2	0.7	-0.8	0.0	0.0	0.5
Time in familiar zone, hab. session 2	0.5	0.6	0.9	1.0	0.7	-0.5	-0.8
Time in novel zone, hab. session 2	0.5	0.5	1.1	-0.8	-0.4	1.1	0.2
Total zone transitions, hab. session 2	2.3	3.0	7.6	-1.1	1.5	2.8	-1.0
Total locomotion distance, hab. session 2	0.8	1.0	2.1	-1.4	0.3	1.5	0.2
Locomotion velocity, hab. session 2	0.8	1.1	2.5	-1.6	-0.0	1.3	0.5
Novel to familiar place preference ratio	0.2	0.3	0.8	0.1	0.3	0.9	-0.4
Novelty place preference	0.2	0.2	0.7	-0.1	-0.1	0.8	-0.1
Time in novel zone, NPP test	0.2	0.2	0.7	-0.1	-0.1	0.8	-0.1
Total zone transitions, NPP test	1.1	1.6	2.8	-0.4	1.7	1.6	-1.0
Total locomotion distance, NPP test	0.3	0.4	1.1	-1.1	0.3	0.7	0.3
Locomotion velocity, NPP test	0.2	0.3	0.9	-0.9	0.3	0.5	0.3
Pavlov. Cond. lever latency	0.2	0.3	0.8	-0.0	-0.9	-0.5	0.4
Pavlov. Cond. magazine entry latency	0.5	0.7	1.6	-0.9	-0.3	1.3	0.3
Pavlov. Cond. change in total contacts	0.5	0.6	1.2	-1.1	-0.5	0.5	0.8
Pavlov. Cond. index score	0.1	0.1	0.2	-0.5	0.0	0.1	0.3
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.5	0.1	0.3	0.2
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.2	0.6	0.3	-0.1
Pavlov. Cond. magazine entry number	0.0	0.1	0.2	0.2	0.1	0.2	-0.4
Pavlov. Cond. intertrial magazine entries	0.4	0.4	1.2	0.4	-0.6	-1.1	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.1	0.2	-0.4	0.2	0.2	0.2
Pavlov. Cond. response bias	0.0	0.1	0.1	-0.3	0.0	0.1	0.3
Bone: apparent density	1.3	2.1	6.6	-1.2	0.3	2.6	-0.4
Bone surface	2.1	3.8	8.7	-0.4	1.8	3.0	-1.7
Bone volume	1.1	1.8	5.6	-0.9	0.6	2.4	-0.6
Bone: connectivity density	2.3	3.5	9.0	-0.4	1.6	3.0	-1.6
Bone: cortical apparent density	0.7	0.9	1.5	1.0	1.2	-0.0	-1.0
Bone: cortical area	0.4	0.6	0.9	1.0	0.8	-0.5	-0.8
Bone: cortical porosity	0.1	0.1	0.1	-0.2	-0.3	0.3	0.1
Bone: cortical porosity	0.2	0.2	0.3	0.5	0.3	0.3	-0.6
Bone: cortical thickness	3.8	6.2	8.1	2.9	2.8	-0.9	-2.8
Bone: cortical thickness	2.0	2.3	3.7	1.6	1.9	-0.2	-1.7
Bone: cortical tissue density	0.8	1.1	1.7	1.1	1.3	-0.1	-1.1
Bone: elastic displacement	1.2	1.3	4.3	0.9	-0.3	-2.1	0.2
Bone: elastic work	1.4	1.8	2.8	1.7	1.3	-0.8	-1.5
Bone: endosteal estimation	1.5	3.1	4.3	-2.1	-1.9	0.8	2.0
Bone: endosteal perimeter	3.2	6.5	9.1	-3.0	-2.8	1.1	2.8
Bone: final force	1.3	2.1	3.3	0.9	1.8	1.1	-1.7
Bone: final moment	1.1	1.8	2.7	0.9	1.7	1.0	-1.6
Bone: marrow area	1.5	3.1	4.3	-2.1	-1.9	0.8	2.0
Bone: maximum diameter	0.1	0.2	0.3	-0.2	-0.5	-0.5	0.5
Bone: maximum force	1.5	2.6	5.7	-0.0	1.5	2.4	-1.5
Bone: maximum moment	1.2	2.2	4.7	0.0	1.4	2.2	-1.4
Bone: minimum diameter	1.6	2.9	4.8	-2.2	-1.6	1.4	1.5
Bone: periosteal estimation	0.1	0.3	0.4	-0.5	-0.7	0.1	0.6
Bone: periosteal perimeter	0.2	0.4	0.5	-0.7	-0.6	0.6	0.6
Bone: post-yield work	3.7	5.1	11.3	-2.8	-0.8	3.4	0.8
Bone: stiffness	1.3	2.0	5.4	-0.2	1.2	2.3	-1.1
Bone: tissue strength	0.4	0.4	0.9	-1.0	-0.4	0.3	0.5
Bone: trabecular number	1.1	1.7	5.5	-1.0	0.4	2.3	-0.5
Bone: trabecular spacing	0.4	0.5	1.5	0.6	-0.1	-1.2	0.2
Bone: trabecular thickness	1.3	1.6	2.5	-1.6	-1.1	1.3	0.9
Bone: trabecular tissue density	3.7	5.2	8.4	-1.2	-2.4	-2.3	2.9
Breakpoint value in progressive ratio session	1.7	1.9	3.1	0.9	1.8	0.9	-1.6
Distance traveled before self-admin	0.1	0.1	0.2	0.2	0.4	0.4	-0.3
Distance traveled after self-admin	0.0	0.0	0.1	-0.1	-0.0	0.3	0.0
Delta time in closed arm before/after self-admin	0.7	0.7	1.1	0.8	1.0	-0.3	-1.0
Delta time in open arm before/after self-admin	0.1	0.1	0.2	-0.3	-0.3	0.1	0.4
Diff in mean of infusions in LGA sessions	0.4	0.4	0.8	0.6	0.9	-0.0	-0.7
Extinction: sum of active levers before priming	2.9	2.9	4.6	1.0	2.1	1.5	-1.9
Active lever presses in extinction session 6	1.2	1.2	1.7	1.3	1.2	-0.6	-1.1
Delta distance traveled before/after self-admin	0.0	0.0	0.1	-0.3	-0.1	-0.1	0.1
Delta ambulatory time before/after self-admin	0.0	0.0	0.0	0.1	0.1	-0.1	-0.2
Time in closed arm before self-admin	0.1	0.1	0.3	-0.3	-0.5	0.3	0.4
Time in closed arm after self-admin	0.1	0.1	0.1	0.4	0.3	-0.3	-0.3
Time in open arm before self-admin	0.3	0.3	0.4	0.6	0.6	-0.1	-0.6
Time in open arm after self-admin	0.0	0.0	0.1	0.3	0.1	-0.2	-0.1
Sum of active levers in priming session hrs 5-6	1.2	1.2	3.0	1.2	0.4	-1.7	-0.3
Time to tail flick, vehicle, before self-admin	1.0	1.0	3.4	-0.4	0.4	1.8	-0.6
Time to tail flick, vehicle, after self-admin	2.2	2.4	3.4	1.2	1.8	1.2	-1.8
Time to tail flick, test, before self-admin	0.6	0.6	2.0	-0.7	-0.0	1.4	0.1
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.4	0.1	0.0	-0.4
Delta time to tail flick, vehicle, before/after SA	1.0	1.0	1.7	1.0	1.3	0.1	-1.1
Delta time to tail flick, test, before/after SA	1.6	1.5	2.5	1.6	0.5	-1.5	-0.9
Ambulatory time before self-admin	0.1	0.1	0.4	0.0	0.2	0.6	-0.0
Ambulatory time after self-admin	0.7	0.7	1.1	-1.0	-0.7	0.9	0.7
Total heroin consumption	3.2	3.8	5.9	1.8	2.3	0.8	-2.4
Area under the delay curve	0.3	0.4	1.2	-0.5	-0.1	1.1	0.1
Delay disc. indifference point, 0s delay	0.7	0.8	2.4	-0.8	-0.2	1.6	0.0
Delay disc. indifference point, 16s delay	0.9	0.9	1.5	-0.9	-1.2	-0.1	1.2
Delay disc. indifference point, 2s delay	0.3	0.3	0.6	-0.7	-0.3	0.6	0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	0.5	0.0	-0.4	-0.3
Delay disc. indifference point, 4s delay	0.2	0.2	0.6	-0.3	0.2	0.8	-0.1
Delay disc. indifference point, 8s delay	0.2	0.2	0.6	0.1	0.1	0.8	-0.3
Delay discount exponential model param	0.2	0.3	0.9	0.4	-0.0	-0.9	-0.0
Delay discount hyperbolic model param	0.3	0.3	0.9	0.4	-0.1	-1.0	-0.0
Fecal boli incidents, locomotor time 1	0.1	0.1	0.1	-0.4	-0.2	-0.1	0.4
Change in fecal boli incidents, locomotor task	0.3	0.3	0.4	0.5	0.4	0.6	-0.6
Time >=10cm from walls, locomotor time 1	1.6	1.6	1.7	-1.3	-1.3	1.2	1.2
Bouts of movement, locomotor time 1	0.8	0.8	1.7	1.3	1.0	-0.4	-0.7
Total resting periods, locomotor time 1	0.4	0.4	0.9	0.9	0.6	-0.5	-0.4
Rest time, locomotor task time 1	1.5	1.7	2.4	-0.6	-1.4	-1.6	1.3
Distance moved, locomotor task time 1	0.4	0.5	1.6	-0.3	0.3	1.3	-0.4
Vertical activity count, locomotor time 1	0.6	0.7	1.0	-0.8	-1.0	0.3	1.0
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.3	-0.2	-0.3	-0.5	0.5
Bouts of movement, locomotor time 2	0.4	0.4	0.5	0.7	0.7	0.1	-0.7
Total resting periods, locomotor time 2	0.1	0.1	0.2	0.4	0.4	0.2	-0.4
Rest time, locomotor task time 2	1.7	2.0	3.2	-1.5	-1.8	0.2	1.6
Distance moved, locomotor task time 2	0.7	0.9	1.2	1.1	1.1	-0.4	-1.0
Vertical activity count, locomotor time 2	0.9	0.9	2.4	1.1	0.3	-1.5	-0.3
Weight adjusted by age	1.3	1.5	3.1	0.9	1.8	0.4	-1.4
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	1.2	-0.5	0.0	1.1	-0.3
Locomotion in novel chamber	4.5	5.6	8.8	-2.2	-2.8	-0.7	3.0
Locomotion in novel chamber post-restriction	2.6	3.1	4.7	-1.6	-2.2	-0.9	2.1
Progressive ratio	2.5	2.9	7.5	-0.3	1.4	2.7	-1.4
Food seeking constrained by brief footshock	0.3	0.4	0.6	0.5	0.7	0.4	-0.8
Seeking ratio, punishment vs. effort	1.5	1.8	4.9	0.4	-1.0	-2.2	1.0
Run reversals in cocaine runway, females	1.4	1.4	3.0	0.1	1.3	1.7	-1.1
Run reversals in cocaine runway, males	0.4	0.4	0.8	0.7	0.3	-0.9	-0.4
Latency to leave start box in cocaine runway	0.5	0.5	1.2	-0.8	-0.2	1.1	0.3
Latency to leave start box in cocaine runway, F	0.3	0.3	1.0	-0.6	-0.0	1.0	0.1
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	-0.1	-0.1	0.1	0.1
Cd content in liver	1.3	1.4	2.1	-0.8	-1.4	-1.0	1.5
Co content in liver	0.4	0.5	1.6	0.1	-0.3	-1.3	0.4
Cu content in liver	0.2	0.2	0.5	0.7	0.5	-0.1	-0.5
Fe content in liver	0.0	0.0	0.1	0.2	0.3	0.2	-0.2
K content in liver	1.4	1.4	2.9	-0.2	1.2	1.7	-1.2
Mg content in liver	1.4	1.5	3.7	-1.4	-0.0	1.9	0.0
Mn content in liver	1.2	1.3	2.2	0.9	1.5	0.7	-1.4
Na content in liver	0.2	0.2	0.3	0.6	0.2	-0.6	-0.3
Rb content in liver	2.1	2.7	5.3	-2.3	-1.5	1.2	1.3
Se content in liver	0.3	0.4	0.7	-0.6	-0.5	0.8	0.4
Sr content in liver	2.4	2.2	3.5	1.9	1.6	-0.4	-1.6
Zn content in liver	0.7	0.8	1.3	0.7	1.1	0.2	-1.1