Hub : Traits : Extensor digitorum longus weight : ← : →

chr2:101,343,693-104,760,530

Trait: Extensor digitorum longus weight

Best TWAS P = 9.79e-09 · Best GWAS P= 2.79e-09 conditioned to 1.00e+00

Associated models

Tissue	Gene	RNA modality	RNA phenotype	h2	# weights	Model R2	Model R2 P	TWAS Z	TWAS P	Coloc P	Joint
Adipose	Pde7a	alternative polyA	XM_006232188.5	0.02	1	0.01	4.1e-02	-5.55	2.93e-08	0.03	FALSE
Adipose	Pde7a	alternative TSS	XM_039103227.2	0.03	21	0.01	1.6e-02	5.23	1.67e-07	0.42	FALSE
Adipose	Pde7a	alternative TSS	XM_039103227.2	0.03	1	0.01	4.6e-02	-5.33	9.56e-08	0.04	FALSE
Adipose	Mtfr1	mRNA stability	Mtfr1	0.08	1	0.04	5.4e-05	5.72	1.06e-08	0.5	FALSE
BLA	Cyp7b1	alternative polyA	XM_039101794.2	0.12	1	0.02	4.6e-02	5.31	1.11e-07	0.04	FALSE
BLA	Cyp7b1	alternative polyA	NM_019138.1	0.15	1	0.02	3.0e-02	-5.31	1.11e-07	0.04	FALSE
BLA	Cyp7b1	alternative polyA	XM_063281357.1	0.14	1	0.02	3.6e-02	5.31	1.11e-07	0.04	FALSE
BLA	Cyp7b1	gene expression	Cyp7b1	0.4	2321	0.22	4.3e-12	5.64	1.66e-08	0.43	FALSE
BLA	Cyp7b1	isoform ratio	NM_019138.1	0.32	1	0.07	9.0e-05	-5.63	1.83e-08	0.16	FALSE
BLA	Cyp7b1	isoform ratio	XM_063281357.1	0.25	42	0.11	1.3e-06	-5.55	2.93e-08	0.32	FALSE
Brain	Armc1	gene expression	Armc1	0.04	165	0.04	2.3e-04	5.28	1.26e-07	0.48	FALSE
Brain	Bhlhe22	gene expression	Bhlhe22	0.08	1	0.05	1.8e-05	5.25	1.51e-07	0.05	FALSE
Brain	Cyp7b1	gene expression	Cyp7b1	0.29	1	0.23	1.3e-21	-5.29	1.23e-07	0.1	FALSE
Brain	LOC120100778	gene expression	LOC120100778	0.05	1	0.03	1.9e-03	-5.25	1.53e-07	0.03	FALSE
Brain	Pde7a	gene expression	Pde7a	0.07	1	0.04	1.1e-04	5.28	1.28e-07	0.12	FALSE
Brain	Cyp7b1	isoform ratio	NM_019138.1	0.08	2321	0.04	3.1e-04	5.73	9.79e-09	0.44	TRUE
Brain	Cyp7b1	isoform ratio	XM_063281357.1	0.15	1	0.09	1.5e-08	5.59	2.32e-08	0.36	FALSE
Brain	Cyp7b1	mRNA stability	Cyp7b1	0.06	1	0.04	1.3e-04	-5.54	2.95e-08	0.07	FALSE
IC	Cyp7b1	gene expression	Cyp7b1	0.14	1538	0.05	4.4e-03	5.67	1.41e-08	0.28	FALSE
IL	Cyp7b1	alternative polyA	NM_019138.1	0.21	251	0.16	1.1e-04	-5.4	6.55e-08	0.35	FALSE
IL	Cyp7b1	alternative polyA	XM_039101794.2	0.22	186	0.17	7.2e-05	5.37	7.84e-08	0.34	FALSE
IL	Cyp7b1	alternative polyA	NM_019138.1	0.23	247	0.17	6.3e-05	-5.4	6.54e-08	0.36	FALSE
IL	Cyp7b1	alternative polyA	XM_063281357.1	0.22	250	0.17	6.7e-05	5.39	6.93e-08	0.35	FALSE
IL	LOC120100778	gene expression	LOC120100778	0.23	1	0.06	1.9e-02	-5.25	1.53e-07	0.05	FALSE
IL	Cyp7b1	isoform ratio	XM_063281357.1	0.29	21	0.21	1.1e-05	-5.46	4.66e-08	0.28	FALSE
LHb	Armc1	gene expression	Armc1	0.32	1548	0.11	1.4e-03	-5.38	7.38e-08	0.54	FALSE
LHb	Armc1	isoform ratio	XM_039101979.2	0.2	1545	0.04	5.2e-02	-5.41	6.17e-08	0.3	FALSE
Liver	Cyp7b1	gene expression	Cyp7b1	0.97	562	0.38	4.3e-45	5.28	1.33e-07	0.53	FALSE
Liver	Mtfr1	gene expression	Mtfr1	0.29	48	0.2	2.9e-22	-5.54	2.96e-08	0.67	FALSE
NAcc	Armc1	gene expression	Armc1	0.05	1548	0.04	1.8e-06	-5.57	2.55e-08	0.55	FALSE
NAcc	Bhlhe22	gene expression	Bhlhe22	0.28	17	0.13	2.1e-19	5.31	1.10e-07	0.15	FALSE
NAcc	Cyp7b1	gene expression	Cyp7b1	0.1	1	0.09	4.4e-14	-5.54	2.95e-08	0.31	FALSE
NAcc	Mtfr1	gene expression	Mtfr1	0.08	1	0.08	1.3e-11	5.56	2.73e-08	0.76	FALSE
NAcc	Pde7a	gene expression	Pde7a	0.03	1	0.03	1.0e-04	5.62	1.96e-08	0.42	FALSE
NAcc	Cyp7b1	isoform ratio	NM_019138.1	0.17	1	0.1	1.6e-15	-5.6	2.13e-08	0.38	FALSE
NAcc	Cyp7b1	isoform ratio	XM_039101794.2	0.02	60	0.01	2.4e-03	-5.49	3.99e-08	0.35	FALSE
NAcc	Cyp7b1	isoform ratio	XM_063281357.1	0.18	62	0.15	7.6e-22	-5.61	1.97e-08	0.41	FALSE
NAcc	Cyp7b1	intron excision ratio	chr2_102577118_102585672	0.01	1	0.01	3.4e-02	5.4	6.77e-08	0.03	FALSE
NAcc	LOC120100778	intron excision ratio	chr2_102045520_102050022	0.02	1	0.01	3.3e-02	5.32	1.06e-07	0.03	FALSE
NAcc	Cyp7b1	mRNA stability	Cyp7b1	0.02	62	0.02	1.7e-03	-5.44	5.30e-08	0.3	FALSE
NAcc	Mtfr1	mRNA stability	Mtfr1	0.03	1	0.03	9.9e-05	5.23	1.67e-07	0.1	FALSE
NAcc	Pde7a	mRNA stability	Pde7a	0.02	1	0.02	6.7e-04	-5.55	2.93e-08	0.16	FALSE
OFC	Crh	gene expression	Crh	0.2	1	0.05	2.2e-02	5.45	5.07e-08	0.15	FALSE
PL	Cyp7b1	alternative polyA	NM_019138.1	0.05	1	0.04	1.3e-05	-5.68	1.32e-08	0.25	FALSE
PL	Cyp7b1	alternative polyA	XM_039101794.2	0.05	1	0.04	1.9e-05	5.68	1.32e-08	0.22	FALSE
PL	Cyp7b1	alternative polyA	NM_019138.1	0.05	1	0.04	2.6e-05	-5.68	1.32e-08	0.31	FALSE
PL	Cyp7b1	alternative polyA	XM_063281357.1	0.05	1	0.05	9.3e-06	5.68	1.32e-08	0.29	FALSE
PL	Cyp7b1	gene expression	Cyp7b1	0.1	199	0.09	2.3e-10	-5.37	7.73e-08	0.29	FALSE
PL	LOC120100778	gene expression	LOC120100778	0.04	1829	0.01	9.7e-03	5.6	2.19e-08	0.49	FALSE
PL	Pde7a	gene expression	Pde7a	0.08	1	0.03	2.9e-04	5.55	2.93e-08	0.22	FALSE
PL	Cyp7b1	isoform ratio	NM_019138.1	0.12	1	0.09	8.6e-10	-5.62	1.95e-08	0.41	FALSE
PL	Cyp7b1	isoform ratio	XM_039101794.2	0.03	1	0.02	3.8e-03	-5.73	1.02e-08	0.03	FALSE
PL	Cyp7b1	isoform ratio	XM_063281357.1	0.16	1	0.13	2.7e-14	5.62	1.95e-08	0.41	FALSE
PL	Cyp7b1	intron excision ratio	chr2_102577118_102585672	0.06	2321	0.04	9.9e-05	-5.24	1.63e-07	0.37	FALSE
pVTA	Armc1	gene expression	Armc1	0.04	1544	0.01	3.6e-02	-5.36	8.49e-08	0.55	FALSE
pVTA	Cyp7b1	gene expression	Cyp7b1	0.08	1538	0.05	1.1e-04	5.69	1.24e-08	0.4	FALSE
pVTA	Mtfr1	gene expression	Mtfr1	0.05	2	0.04	2.2e-04	-5.23	1.68e-07	0.62	FALSE
pVTA	Cyp7b1	isoform ratio	XM_063281357.1	0.13	22	0.06	1.3e-05	-5.32	1.03e-07	0.33	FALSE
pVTA	Cyp7b1	intron excision ratio	chr2_102554587_102585672	0.03	1538	0.01	3.2e-02	5.68	1.33e-08	0.26	FALSE
pVTA	Cyp7b1	intron excision ratio	chr2_102577118_102585672	0.04	17	0.02	4.8e-03	-5.41	6.30e-08	0.26	FALSE