Hub : Genes

Fam124a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000009802 0.03 0.02 7.4e-04 0.03 0.03 0.03 0.02 3.1e-04 8.0e-04 6.8e-04 1.2e-03
2 BLA mRNA stability ENSRNOG00000009802 0.05 0.04 4.4e-03 0.06 0.03 0.02 0.05 5.3e-04 1.6e-02 3.2e-02 1.4e-03
3 Brain mRNA stability ENSRNOG00000009802 0.04 0.02 4.8e-03 0.01 0.02 0.01 0.01 2.1e-02 4.9e-03 2.9e-02 1.7e-02
4 PL gene expression ENSRNOG00000009802 0.03 0.02 7.7e-03 0.02 0.01 0 0.01 1.6e-02 7.7e-02 2.5e-01 1.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail0.30.91.31.1-1.0-0.41.2
BMI without tail0.10.20.40.10.10.6-0.5
Body weight0.83.34.01.8-2.0-1.71.7
Epididymis fat weight0.20.51.0-0.70.5-1.0-0.1
Glucose0.40.61.11.0-0.90.40.5
Heart weight0.00.00.10.1-0.20.1-0.2
Left kidney weight1.85.16.42.4-2.5-1.52.4
Right kidney weight2.67.58.92.8-2.9-2.23.0
Tail length0.10.20.5-0.1-0.2-0.7-0.6
Length with tail0.31.02.40.4-1.0-1.50.6
Length without tail1.02.13.10.9-1.4-1.71.6
Liver weight, left3.96.38.93.0-3.0-1.72.1
Liver weight, right0.10.20.40.4-0.3-0.60.5
Parametrial fat weight2.04.05.5-2.42.10.8-2.3
Retroperitoneal fat weight0.20.71.2-1.11.0-0.4-0.8
Intraocular pressure2.73.84.8-2.02.11.5-2.2
Extensor digitorum longus weight7.530.334.35.9-5.6-5.15.4
Soleus weight0.51.32.21.5-1.4-0.90.6
Tibialis anterior weight8.027.733.55.8-5.5-4.25.4
Tibia length0.61.62.41.4-1.40.41.5
Number of licking bursts0.10.20.40.4-0.60.00.3
Food consumed during 24 hour testing period0.20.20.60.8-0.50.20.2
Times rat made contact with spout0.70.81.31.1-1.1-0.20.7
Mean time between licks in bursts1.62.34.3-0.91.02.1-1.7
Mean num. licks in bursts0.00.00.10.4-0.1-0.10.2
Std. dev. time between licks in bursts1.82.12.6-1.51.61.0-1.6
Water consumed over 24 hours0.50.60.90.9-1.0-0.60.7
Indifference point 0 sec0.00.00.1-0.1-0.0-0.10.2
Indifference point AUC0.40.40.90.8-0.40.90.2
Indifference point function ln k0.50.71.90.2-0.6-1.40.8
Indifference point function log k0.50.71.90.2-0.6-1.40.8
Delay discounting total patch changes 0 sec0.10.20.30.3-0.5-0.60.6
Delay discounting total patch changes 12 sec0.50.61.31.1-0.90.30.6
Delay discounting total patch changes 18 sec0.10.20.40.6-0.4-0.30.1
Delay discounting total patch changes 24 sec0.60.71.01.0-1.0-0.70.7
Delay discounting total patch changes 6 sec0.10.20.50.4-0.20.70.2
Delay discounting time to switch 0 sec0.20.30.5-0.70.7-0.1-0.6
Delay discounting water rate 0 sec1.11.72.61.1-1.2-1.21.6
Delay discounting water rate 12 sec3.04.45.61.7-2.2-2.42.0
Delay discounting water rate 18 sec6.38.410.42.8-3.0-2.63.2
Delay discounting water rate 24 sec0.91.33.10.7-1.0-1.80.7
Delay discounting water rate 6 sec2.33.35.11.5-1.8-2.31.6
Locomotor activity3.35.26.02.2-2.5-2.42.1
Locomotor testing distance0.40.71.10.7-1.0-1.00.6
Locomotor testing rearing0.10.20.60.1-0.30.80.2
Light reinforcement 10.50.91.30.8-1.0-0.81.1
Light reinforcement 20.40.61.3-1.11.0-0.1-0.2
Reaction time number correct0.20.20.8-0.20.20.9-0.3
Reaction time mean minus median0.00.00.10.0-0.1-0.40.1
Reaction time mean minus median AUC0.10.10.2-0.00.10.5-0.0
Reaction time num false alarms0.30.40.70.8-0.9-0.30.3
Reaction time num false alarms AUC0.60.81.41.2-1.2-0.40.5
Reaction time trials correct on left0.20.20.8-0.20.20.9-0.3
Reaction time trials on left0.20.31.1-0.30.31.0-0.4
Reaction time mean0.50.71.1-1.00.90.1-0.9
Reaction time mean AUC0.70.91.5-1.21.10.2-1.0
Median of all reaction times0.81.11.6-1.31.20.1-1.1
Reaction time omissions2.43.35.6-1.41.62.4-1.8
Reaction time false alarm rate0.70.91.41.2-1.1-0.80.7
Reaction time premature initiation rate0.50.71.30.5-0.9-1.20.5
Reaction time premature initiations0.10.20.30.2-0.6-0.50.0
Std. dev. reaction times0.30.50.7-0.80.80.4-0.6
Reaction time trials completed0.20.31.1-0.30.31.0-0.4
Reaction time trials AUC0.20.31.0-0.30.31.0-0.4
Social response proportion2.83.13.8-1.91.91.5-1.6
Social responses1.82.43.0-1.51.51.4-1.7
Social time0.81.01.51.1-0.80.71.2
Conditioned locomotion0.70.81.8-0.90.8-1.3-0.3
Cocaine response after cond. corrected0.60.71.2-1.10.7-0.3-0.9
Cocaine response after cond. not corrected0.50.50.9-1.00.6-0.3-0.7
Cocaine response before conditioning0.40.50.70.8-0.8-0.20.8
Saline control response0.10.20.4-0.30.4-0.3-0.7
Condit. Reinf. active minus inactive responses0.10.10.20.4-0.4-0.00.3
Condit. Reinf. active-inactive response ratio0.40.40.60.8-0.80.20.6
Condit. Reinf. active responses0.30.40.60.8-0.7-0.40.6
Condit. Reinf. inactive responses0.30.30.5-0.60.7-0.1-0.7
Condit. Reinf. lever presses2.63.66.22.5-2.1-0.61.8
Condit. Reinf. lever reinforcers received0.50.71.21.1-0.9-0.50.8
Pavlov. Cond. lever latency3.24.46.6-2.62.20.9-2.3
Pavlov. Cond. magazine entry latency1.71.93.01.6-1.2-1.70.9
Pavlov. Cond. change in total contacts4.05.67.72.8-2.5-1.72.3
Pavlov. Cond. index score3.34.36.32.5-2.1-1.62.0
Pavlov. Cond. latency score3.24.06.02.4-2.0-1.61.9
Pavlov. Cond. lever contacts2.94.16.22.5-2.1-1.02.2
Pavlov. Cond. magazine entry number1.72.02.9-1.71.41.4-1.1
Pavlov. Cond. intertrial magazine entries3.64.68.7-1.81.82.9-1.8
Pavlov. Cond. lever-magazine prob. diff.2.93.85.72.4-1.9-1.61.8
Pavlov. Cond. response bias3.34.66.52.5-2.1-1.62.2
Conditioned reinforcement - actives9.19.011.1-3.23.31.8-3.3
Conditioned reinforcement - inactives3.74.14.7-1.92.22.0-2.0
Conditioned locomotion3.44.16.5-2.32.50.6-2.1
Intermittent access intake day 1-15 change1.11.12.6-1.10.60.6-1.6
Intermittent access intake escalation1.71.63.9-1.20.80.7-2.0
Intermittent access intake escalation 20.80.81.6-0.80.60.8-1.3
Intermitt. access day 1 inactive lever presses4.95.37.5-2.02.42.7-2.0
Intermitt. access day 15 inactive lever presses1.31.41.7-1.21.31.1-1.1
Intermitt. access escalation Index0.50.40.70.8-0.70.60.4
Intermittent access day 1 total infusions0.20.30.5-0.40.7-0.1-0.7
Intermittent access day 15 total infusions2.42.74.8-1.61.51.1-2.2
Intermittent access terminal intake (last 3 days)1.71.93.0-1.31.31.0-1.7
Intermittent access total infusions2.62.94.0-1.71.90.9-2.0
Intermittent access day 1 locomotion0.10.10.3-0.20.5-0.2-0.2
Intermittent access day 15 total locomotion2.02.14.1-1.41.40.5-2.0
Intermittent access total locomotion1.31.52.1-1.21.40.4-1.4
Intermittent access standard deviation0.91.01.8-1.20.90.1-1.3
Cocaine induced anxiety0.60.71.30.5-0.6-1.01.2
Post-drug Anxiety0.10.20.60.1-0.2-0.00.8
Baseline Anxiety0.10.10.2-0.30.40.5-0.4
Lifetime Intake2.73.14.3-1.81.90.9-2.1
Incentive Sensitization - Responses3.83.88.2-1.21.12.9-2.1
Incentive Sensitization - Breakpoint3.53.57.9-1.11.02.8-2.0
Progressive ratio test 1 active lever presses0.20.20.4-0.30.60.5-0.5
Progressive ratio test 1 breakpoint0.20.20.3-0.20.50.4-0.4
Progressive ratio test 1 inactive lever presses0.91.01.8-0.81.11.3-0.5
Progressive ratio test 2 active lever presses3.63.86.4-1.41.52.5-2.1
Progressive ratio test 2 breakpoint2.52.85.7-1.11.22.4-1.7
Progressive ratio test 2 inactive lever presses2.02.35.4-0.91.22.3-1.4
Total sessions with >9 infusions4.65.05.8-2.32.41.9-2.3
Short access day 1 total inactive lever presses0.10.10.2-0.40.40.5-0.1
Short access day 10 total inactive lever presses0.40.41.60.2-0.11.30.0
Short access day 1 total infusions3.94.15.4-2.32.31.3-2.1
Short access day 10 total infusions0.30.30.4-0.60.7-0.6-0.4
Short access total infusions1.41.62.2-1.51.50.3-1.4
Short access day 1 locomotion1.51.62.7-1.41.60.6-1.0
Short access day 10 total locomotion0.00.00.10.00.1-0.20.0
Short access total locomotion0.40.40.7-0.70.80.2-0.5
Compulsive drug intake0.40.41.00.7-0.4-0.11.0
One hour access (0.3 mA shock)2.42.83.8-1.41.61.6-1.9
One hour access (shock baseline)3.64.26.3-2.12.01.4-2.5
Number of responses in last shaping day0.60.61.0-1.00.6-0.5-0.8
Context. condit. distance diff. score0.10.20.2-0.40.4-0.4-0.3
Locomotion velocity, session 10.70.71.21.1-1.0-0.50.7
Locomotion distance, session 10.91.21.91.1-1.2-0.41.4
Locomotion velocity, session 20.60.71.30.7-0.7-0.81.1
Locomotion distance, session 20.20.30.60.4-0.40.30.8
Locomotion velocity, session 31.11.31.81.2-1.3-0.61.2
Locomotion distance, session 31.71.82.71.4-1.4-0.81.6
Stereotopy head waving bouts, day 30.91.11.7-1.11.00.7-1.3
Stereotopy head waving duration, day 30.00.00.10.1-0.2-0.1-0.1
Locomotion velocity, session 70.10.10.3-0.1-0.00.60.2
Locomotion distance, session 71.21.52.0-1.41.31.1-1.0
Stereotopy head waving bouts, day 72.42.73.82.0-2.0-1.01.4
Stereotopy head waving duration, day 73.74.55.92.4-2.4-1.52.0
Locomotion velocity, session 80.91.01.90.5-0.7-1.41.2
Locomotion distance, session 80.20.30.60.3-0.3-0.60.8
Degree of sensitization distance7.07.18.3-2.92.82.2-2.6
Degree of sensitization stereotypy3.23.54.22.0-2.0-1.71.8
Condit. Reinf. active minus inactive responses1.01.12.51.6-1.2-0.10.8
Condit. Reinf. active-inactive response ratio0.20.30.70.4-0.00.8-0.3
Condit. Reinf. active responses1.62.03.71.9-1.6-0.81.0
Condit. Reinf. inactive responses1.31.62.31.2-1.3-1.51.0
Incentive salience index mean2.12.54.52.1-1.8-0.81.3
Condit. Reinf. lever presses2.23.04.52.1-1.9-1.31.5
Time in familiar zone, hab. session 10.10.10.30.4-0.3-0.5-0.2
Time in novel zone, hab. session 10.10.10.2-0.40.30.30.1
Total zone transitions, hab. session 11.11.52.91.2-1.1-0.71.7
Total locomotion distance, hab. session 10.30.40.50.7-0.6-0.40.6
Locomotion velocity, hab. session 10.50.71.01.0-0.8-0.80.7
Time in familiar zone, hab. session 20.60.61.2-0.60.7-0.6-1.1
Time in novel zone, hab. session 20.40.40.90.4-0.60.61.0
Total zone transitions, hab. session 22.93.84.91.9-2.0-1.72.2
Total locomotion distance, hab. session 22.12.83.01.7-1.6-1.71.7
Locomotion velocity, hab. session 22.33.13.51.8-1.7-1.71.9
Novel to familiar place preference ratio1.51.62.3-1.51.31.1-1.0
Novelty place preference1.31.42.1-1.41.31.0-0.9
Time in novel zone, NPP test1.31.42.0-1.41.31.0-0.9
Total zone transitions, NPP test1.31.92.71.4-1.4-0.81.7
Total locomotion distance, NPP test0.10.20.80.1-0.20.90.1
Locomotion velocity, NPP test0.10.20.60.3-0.30.80.2
Pavlov. Cond. lever latency0.50.61.1-0.90.80.3-1.0
Pavlov. Cond. magazine entry latency0.00.00.00.20.00.1-0.2
Pavlov. Cond. change in total contacts0.30.30.70.5-0.4-0.30.8
Pavlov. Cond. index score1.11.42.11.3-1.2-0.61.4
Pavlov. Cond. latency score0.81.01.61.1-1.0-0.31.3
Pavlov. Cond. lever contacts0.70.81.21.0-0.8-0.41.1
Pavlov. Cond. magazine entry number0.40.40.7-0.90.70.2-0.7
Pavlov. Cond. intertrial magazine entries1.51.82.71.6-1.5-1.11.1
Pavlov. Cond. lever-magazine prob. diff.1.41.72.61.5-1.3-0.61.6
Pavlov. Cond. response bias1.31.62.21.5-1.3-0.91.2
Bone: apparent density0.10.10.4-0.20.30.6-0.1
Bone surface0.10.10.2-0.40.30.50.0
Bone volume0.00.00.1-0.20.20.30.1
Bone: connectivity density0.50.70.9-0.90.90.9-0.7
Bone: cortical apparent density0.40.61.21.1-1.0-0.20.4
Bone: cortical area0.10.10.40.2-0.1-0.20.7
Bone: cortical porosity2.72.95.21.5-1.3-2.31.6
Bone: cortical porosity2.52.74.81.4-1.3-2.21.5
Bone: cortical thickness0.30.50.80.7-0.6-0.70.9
Bone: cortical thickness1.01.21.91.0-0.9-1.11.4
Bone: cortical tissue density0.40.51.21.1-0.9-0.20.3
Bone: elastic displacement0.30.30.4-0.60.7-0.4-0.5
Bone: elastic work0.30.40.60.6-0.6-0.80.2
Bone: endosteal estimation0.10.30.4-0.60.60.6-0.3
Bone: endosteal perimeter0.61.21.9-1.41.40.6-0.7
Bone: final force1.11.92.41.5-1.5-1.41.0
Bone: final moment1.42.32.91.7-1.7-1.51.2
Bone: marrow area0.20.30.4-0.70.70.6-0.4
Bone: maximum diameter0.30.61.2-1.01.10.1-0.3
Bone: maximum force1.11.82.61.3-1.4-1.61.0
Bone: maximum moment1.32.22.71.5-1.6-1.71.1
Bone: minimum diameter0.00.10.1-0.30.30.10.2
Bone: periosteal estimation0.20.30.6-0.60.70.6-0.1
Bone: periosteal perimeter0.20.40.7-0.80.80.5-0.1
Bone: post-yield work0.30.41.20.3-0.4-1.10.5
Bone: stiffness0.40.60.80.8-0.9-0.50.9
Bone: tissue strength0.50.51.4-0.30.20.7-1.2
Bone: trabecular number0.40.60.9-0.90.90.6-0.5
Bone: trabecular spacing0.30.41.20.4-0.5-1.10.2
Bone: trabecular thickness1.11.32.21.2-1.2-0.61.5
Bone: trabecular tissue density0.60.81.30.9-1.0-0.61.1
Breakpoint value in progressive ratio session0.20.20.40.1-0.5-0.2-0.6
Distance traveled before self-admin0.10.10.30.2-0.1-0.5-0.4
Distance traveled after self-admin0.70.71.8-0.91.3-0.5-0.4
Delta time in closed arm before/after self-admin0.10.10.20.1-0.3-0.4-0.3
Delta time in open arm before/after self-admin4.54.26.7-1.82.32.6-1.3
Diff in mean of infusions in LGA sessions0.40.41.10.3-1.0-0.80.2
Extinction: sum of active levers before priming0.30.31.0-0.30.20.2-1.0
Active lever presses in extinction session 60.10.10.2-0.1-0.3-0.2-0.5
Delta distance traveled before/after self-admin1.41.53.2-1.31.80.9-0.2
Delta ambulatory time before/after self-admin0.80.81.8-1.11.30.5-0.3
Time in closed arm before self-admin2.32.63.41.6-1.4-1.51.9
Time in closed arm after self-admin3.83.94.72.0-1.9-2.21.9
Time in open arm before self-admin0.50.51.40.4-0.7-1.20.3
Time in open arm after self-admin2.52.85.0-1.31.62.2-1.4
Sum of active levers in priming session hrs 5-60.10.10.3-0.10.00.5-0.1
Time to tail flick, vehicle, before self-admin0.20.20.50.3-0.5-0.70.3
Time to tail flick, vehicle, after self-admin0.30.30.60.4-0.6-0.80.3
Time to tail flick, test, before self-admin0.90.91.41.2-1.2-0.40.7
Time to tail flick, test, after self-admin2.32.32.9-1.51.61.2-1.7
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.10.20.5-0.3
Delta time to tail flick, test, before/after SA2.92.63.5-1.81.91.0-1.6
Ambulatory time before self-admin0.70.71.40.9-0.7-1.20.5
Ambulatory time after self-admin0.60.72.30.00.3-1.50.6
Total heroin consumption0.10.10.20.5-0.40.10.1
Area under the delay curve4.14.46.61.7-1.8-2.62.2
Delay disc. indifference point, 0s delay0.30.30.70.3-0.3-0.80.5
Delay disc. indifference point, 16s delay1.61.63.80.6-1.0-2.01.1
Delay disc. indifference point, 2s delay1.82.12.81.4-1.4-1.71.3
Delay disc. indifference point, 24s delay0.80.81.20.7-0.6-1.01.1
Delay disc. indifference point, 4s delay4.04.26.61.7-1.7-2.62.1
Delay disc. indifference point, 8s delay3.63.85.51.5-1.7-2.12.3
Delay discount exponential model param5.15.47.2-2.02.12.7-2.5
Delay discount hyperbolic model param5.25.57.5-2.02.12.7-2.5
Fecal boli incidents, locomotor time 12.62.83.92.0-1.7-0.52.0
Change in fecal boli incidents, locomotor task1.21.11.9-1.31.40.5-0.7
Time >=10cm from walls, locomotor time 10.10.10.20.3-0.4-0.3-0.0
Bouts of movement, locomotor time 10.60.71.20.9-0.8-0.31.1
Total resting periods, locomotor time 10.50.50.90.9-0.6-0.11.0
Rest time, locomotor task time 12.22.43.82.0-1.70.11.7
Distance moved, locomotor task time 11.51.62.7-1.51.2-0.1-1.7
Vertical activity count, locomotor time 11.51.62.4-1.61.1-1.0-1.3
Time >=10cm from walls, locomotor time 20.10.10.3-0.2-0.1-0.6-0.4
Bouts of movement, locomotor time 20.30.30.90.4-0.1-0.30.9
Total resting periods, locomotor time 20.60.61.60.8-0.4-0.21.3
Rest time, locomotor task time 22.12.53.91.9-1.5-0.02.0
Distance moved, locomotor task time 20.50.61.2-0.80.3-0.7-1.1
Vertical activity count, locomotor time 21.61.72.2-1.41.0-1.4-1.5
Weight adjusted by age1.41.62.11.5-1.4-0.51.4
Seeking ratio, delayed vs. immediate footshock1.61.83.3-1.81.8-0.4-0.8
Locomotion in novel chamber1.21.41.91.2-1.0-1.11.4
Locomotion in novel chamber post-restriction0.60.71.7-0.1-0.1-1.01.3
Progressive ratio0.20.20.4-0.0-0.1-0.60.6
Food seeking constrained by brief footshock0.60.71.9-0.40.70.6-1.4
Seeking ratio, punishment vs. effort0.10.10.50.2-0.10.1-0.7
Run reversals in cocaine runway, females1.11.12.1-1.31.50.3-0.6
Run reversals in cocaine runway, males1.01.01.11.0-1.0-0.91.0
Latency to leave start box in cocaine runway0.70.81.1-1.01.11.0-0.2
Latency to leave start box in cocaine runway, F1.31.42.3-1.31.11.5-0.7
Latency to leave start box in cocaine runway, M0.20.20.40.30.30.60.5
Cd content in liver0.91.01.9-0.90.91.4-0.8
Co content in liver0.60.71.40.6-0.8-1.20.7
Cu content in liver1.31.62.31.5-1.5-0.01.4
Fe content in liver0.60.71.1-0.80.61.1-0.9
K content in liver0.10.10.40.2-0.1-0.6-0.3
Mg content in liver0.60.61.3-0.70.70.2-1.2
Mn content in liver0.50.61.3-0.80.60.0-1.1
Na content in liver3.03.24.31.9-2.1-1.61.5
Rb content in liver2.93.64.8-2.22.00.9-2.2
Se content in liver2.02.43.4-1.81.80.8-1.6
Sr content in liver1.51.44.2-0.70.72.0-0.6
Zn content in liver1.82.02.91.7-1.4-1.41.1