Hub : Traits

Intermittent access intake escalation

Intermittent access day 15 minus day 1 infusions

Tags: Behavior · Intermittent access · Cocaine

Project: p50_paul_meyer_2020

5 loci · 6 genes with independent associations · 7 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr2	144511896	145907690	1	1	8.93e-08	4.52e-01	1.0e+00	Mindy4b
2	chr8	41432021	42858939	2	2	1.03e-38	8.34e-04	5.8e-10	Foxred1 Pus3
3	chr8	117463629	118343328	1	1	1.20e-07	4.77e-02	1.0e+00	Mst1
4	chr9	83390749	84777604	2	1	0.00e+00	4.32e-02	1.0e+00	Retreg2
5	chr17	56581483	57955699	1	1	2.64e-11	2.37e-01	1.0e+00	LOC108348573

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	293.78	3	2	33.3	0	1.00e+00	Foxred1 Mindy4b Retreg2
BMI without tail	19090.39	2	1	16.7	0	1.00e+00	Mindy4b Retreg2
Body weight	6.51	3	2	33.3	0	1.00e+00	Mindy4b Mst1 Retreg2
Epididymis fat weight	12103.91	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Glucose	336.01	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Heart weight	3065.65	1	1	16.7	0	1.00e+00	Retreg2
Left kidney weight	11012.82	4	1	16.7	-1	8.46e-06	Foxred1 LOC108348573 Mindy4b Retreg2
Right kidney weight	10106.34	3	2	33.3	-1	1.39e-03	Foxred1 Mst1 Retreg2
Tail length	7235.18	3	1	16.7	1	7.72e-05	LOC108348573 Mst1 Retreg2
Length with tail	300.66	4	2	33.3	1	2.65e-04	Foxred1 LOC108348573 Mst1 Retreg2
Length without tail	11814.8	3	2	33.3	-1	3.67e-04	Mindy4b Mst1 Retreg2
Liver weight, left	1755.51	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Liver weight, right	31.11	3	2	33.3	0	1.00e+00	Mindy4b Mst1 Retreg2
Parametrial fat weight	92.67	2	1	16.7	0	1.00e+00	Foxred1 Retreg2
Retroperitoneal fat weight	994.86	3	2	33.3	0.99	7.88e-03	Mindy4b Mst1 Retreg2
Intraocular pressure	5196.88	1	1	16.7	0	1.00e+00	Retreg2
Extensor digitorum longus weight	271.76	4	1	16.7	1	2.72e-05	Mindy4b Mst1 Pus3 Retreg2
Soleus weight	9.02	3	1	16.7	0	1.00e+00	Mst1 Pus3 Retreg2
Tibialis anterior weight	580.28	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Tibia length	396.37	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Number of licking bursts	33719.1	1	1	16.7	0	1.00e+00	Retreg2
Food consumed during 24 hour testing period	11842.94	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Times rat made contact with spout	71.66	1	1	16.7	0	1.00e+00	Retreg2
Mean time between licks in bursts	55818.77	1	1	16.7	0	1.00e+00	Retreg2
Mean num. licks in bursts	28381.96	1	1	16.7	0	1.00e+00	Retreg2
Std. dev. time between licks in bursts	14881.26	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Water consumed over 24 hours	11394.43	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Patch foraging indifference point 0 sec	19591.07	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Patch foraging indifference point AUC	16747.02	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Indifference point function ln k	18606.98	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Indifference point function log k	18606.98	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Patch foraging total patch changes 0 sec	20977.37	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Patch foraging total patch changes 12 sec	790.53	3	2	33.3	0	1.00e+00	Foxred1 Mst1 Retreg2
Patch foraging total patch changes 18 sec	20236.6	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Patch foraging total patch changes 24 sec	18715.11	3	2	33.3	1	9.33e-05	Mindy4b Mst1 Retreg2
Patch foraging total patch changes 6 sec	3896.58	2	1	16.7	0	1.00e+00	Mindy4b Retreg2
Patch foraging time to switch 0 sec	22170.23	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Patch foraging water rate 0 sec	30218.69	1	1	16.7	0	1.00e+00	Retreg2
Patch foraging water rate 12 sec	23554.52	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Patch foraging water rate 18 sec	16867.27	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Patch foraging water rate 24 sec	523.92	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Patch foraging water rate 6 sec	837.86	1	1	16.7	0	1.00e+00	Retreg2
Locomotor activity	17.85	2	1	16.7	0	1.00e+00	Foxred1 Mst1
Locomotor testing distance	6929.45	3	2	33.3	-1	3.52e-04	Foxred1 Mst1 Retreg2
Locomotor testing rearing	12694.13	4	2	33.3	-1	4.39e-06	Foxred1 Mindy4b Mst1 Retreg2
Light reinforcement 1	16585.18	3	1	16.7	-1	2.09e-04	Mindy4b Mst1 Retreg2
Light reinforcement 2	9203.31	3	2	33.3	-1	1.28e-03	Mindy4b Mst1 Retreg2
Reaction time number correct	31742.5	1	1	16.7	0	1.00e+00	Retreg2
Reaction time mean minus median	39992.94	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Reaction time mean minus median AUC	41345.26	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Reaction time num false alarms	7685.9	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Reaction time num false alarms AUC	11677.59	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Reaction time trials correct on left	31742.5	1	1	16.7	0	1.00e+00	Retreg2
Reaction time trials on left	30448.08	1	1	16.7	0	1.00e+00	Retreg2
Reaction time mean	9922.47	2	2	33.3	0	1.00e+00	Mindy4b Retreg2
Reaction time mean AUC	12936.48	2	2	33.3	0	1.00e+00	Mindy4b Retreg2
Median of all reaction times	2647.07	2	2	33.3	0	1.00e+00	Mindy4b Retreg2
Reaction time omissions	2795.21	3	1	16.7	0	1.00e+00	Mindy4b Mst1 Retreg2
Reaction time false alarm rate	111.7	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Reaction time premature initiation rate	4871.37	2	1	16.7	0	1.00e+00	Mindy4b Retreg2
Reaction time premature initiations	17919.9	2	1	16.7	0	1.00e+00	Mindy4b Retreg2
Std. dev. reaction times	15225.26	3	1	16.7	1	1.33e-04	Mindy4b Mst1 Retreg2
Reaction time trials completed	30448.08	1	1	16.7	0	1.00e+00	Retreg2
Reaction time trials AUC	31071.4	1	1	16.7	0	1.00e+00	Retreg2
Social response proportion	2935.9	3	1	16.7	0	1.00e+00	Mindy4b Mst1 Retreg2
Social responses	640.25	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Social time	5828.31	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Conditioned locomotion	1400.08	1	1	16.7	0	1.00e+00	Retreg2
Cocaine response after cond. corrected	9573.48	1	1	16.7	0	1.00e+00	Retreg2
Cocaine response after cond. not corrected	9294.65	1	1	16.7	0	1.00e+00	Retreg2
Cocaine response before conditioning	655.41	1	1	16.7	0	1.00e+00	Retreg2
Saline control response	1639.18	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. active minus inactive responses	7271.32	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. active-inactive response ratio	28713.86	1	1	16.7	0	1.00e+00	Retreg2
Condit. Reinf. active responses	1165.18	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. inactive responses	5466.41	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. lever presses	1963.38	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. lever reinforcers received	243.91	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever latency	1278.33	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. magazine entry latency	6738.25	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. change in total contacts	19908.31	1	1	16.7	0	1.00e+00	Retreg2
Pavlov. Cond. index score	6407.33	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. latency score	8109.24	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever contacts	2689.72	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. magazine entry number	2097.69	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. intertrial magazine entries	11707.89	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever-magazine prob. diff.	5938.34	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. response bias	641.31	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Conditioned reinforcement - actives	50404.9	1	1	16.7	0	1.00e+00	Retreg2
Conditioned reinforcement - inactives	16259.91	3	2	33.3	1	3.71e-04	Foxred1 Mst1 Retreg2
Conditioned locomotion	2595.05	4	2	33.3	1	4.46e-03	Foxred1 Mindy4b Mst1 Retreg2
Intermittent access intake day 1-15 change	18284.28	6	4	66.7	1	1.42e-11	Foxred1 LOC108348573 Mindy4b Mst1 Pus3 Retreg2
Intermittent access intake escalation 2	7277.27	5	4	66.7	1	7.64e-07	Foxred1 LOC108348573 Mst1 Pus3 Retreg2
Intermitt. access day 1 inactive lever presses	60238.86	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Intermitt. access day 15 inactive lever presses	24738.14	4	2	33.3	1	6.40e-09	Foxred1 LOC108348573 Pus3 Retreg2
Intermitt. access escalation Index	23357.21	3	2	33.3	-1	2.28e-04	Mindy4b Mst1 Retreg2
Intermittent access day 1 total infusions	11027.24	5	1	16.7	-1	2.13e-08	Foxred1 LOC108348573 Mindy4b Mst1 Retreg2
Intermittent access day 15 total infusions	9764.48	4	3	50	1	4.03e-07	Foxred1 LOC108348573 Pus3 Retreg2
Intermittent access terminal intake (last 3 days)	8288.18	3	2	33.3	0	1.00e+00	Foxred1 Pus3 Retreg2
Intermittent access total infusions	66.67	3	1	16.7	0	1.00e+00	Foxred1 Pus3 Retreg2
Intermittent access day 1 locomotion	8748.38	3	1	16.7	-1	1.40e-04	Foxred1 Mindy4b Retreg2
Intermittent access day 15 total locomotion	28521.14	2	1	16.7	0	1.00e+00	LOC108348573 Retreg2
Intermittent access total locomotion	46.76	3	1	16.7	0	1.00e+00	Mindy4b Mst1 Retreg2
Intermittent access standard deviation	22803.94	4	2	33.3	1	1.20e-06	Foxred1 LOC108348573 Mst1 Retreg2
Cocaine induced anxiety	23043.66	2	1	16.7	0	1.00e+00	Foxred1 Retreg2
Post-drug Anxiety	2380.44	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Baseline Anxiety	16757.7	2	1	16.7	0	1.00e+00	Foxred1 Retreg2
Lifetime Intake	559.22	3	1	16.7	0	1.00e+00	Foxred1 Pus3 Retreg2
Incentive Sensitization - Responses	23796.84	2	2	33.3	0	1.00e+00	Mindy4b Retreg2
Incentive Sensitization - Breakpoint	13830.07	3	2	33.3	-1	7.18e-04	Foxred1 Mindy4b Retreg2
Progressive ratio test 1 active lever presses	10667.39	2	1	16.7	0	1.00e+00	LOC108348573 Retreg2
Progressive ratio test 1 breakpoint	10104.83	2	1	16.7	0	1.00e+00	LOC108348573 Retreg2
Progressive ratio test 1 inactive lever presses	15566.12	3	2	33.3	1	3.87e-05	Foxred1 Mst1 Retreg2
Progressive ratio test 2 active lever presses	5092.84	2	1	16.7	0	1.00e+00	Mindy4b Retreg2
Progressive ratio test 2 breakpoint	4276.62	2	1	16.7	0	1.00e+00	Mindy4b Retreg2
Progressive ratio test 2 inactive lever presses	18133.29	3	1	16.7	1	3.70e-04	Foxred1 Mst1 Retreg2
Total sessions with >9 infusions	676.6	3	2	33.3	0	1.00e+00	Mindy4b Mst1 Retreg2
Short access day 1 total inactive lever presses	7908.54	4	3	50	-1	1.87e-04	Foxred1 Mindy4b Mst1 Retreg2
Short access day 10 total inactive lever presses	34734.71	3	2	33.3	1	6.97e-05	LOC108348573 Mst1 Retreg2
Short access day 1 total infusions	9601.91	3	1	16.7	-1	1.40e-03	Foxred1 Mst1 Retreg2
Short access day 10 total infusions	5688.19	4	2	33.3	-1	8.27e-04	LOC108348573 Mindy4b Mst1 Retreg2
Short access total infusions	4396.25	2	1	16.7	0	1.00e+00	Mindy4b Retreg2
Short access day 1 locomotion	8276.04	3	1	16.7	0	1.00e+00	Foxred1 Mst1 Retreg2
Short access day 10 total locomotion	14715.06	5	3	50	1	1.16e-06	Foxred1 Mindy4b Mst1 Pus3 Retreg2
Short access total locomotion	4692.46	4	4	66.7	1	4.58e-04	Foxred1 Mindy4b Mst1 Retreg2
Compulsive drug intake	4681.07	4	2	33.3	-1	1.72e-03	Foxred1 Mindy4b Mst1 Retreg2
One hour access (0.3 mA shock)	486.67	5	2	33.3	0.98	3.18e-03	Foxred1 LOC108348573 Mindy4b Pus3 Retreg2
One hour access (shock baseline)	13754.92	3	1	16.7	1	1.54e-05	Foxred1 Pus3 Retreg2
Number of responses in last shaping day	2730.85	4	1	16.7	1	1.11e-05	Foxred1 Mindy4b Mst1 Retreg2
Context. condit. distance diff. score	212.47	1	1	16.7	0	1.00e+00	Retreg2
Locomotion velocity, session 1	3523.61	1	1	16.7	0	1.00e+00	Retreg2
Locomotion distance, session 1	1024.77	1	1	16.7	0	1.00e+00	Retreg2
Locomotion velocity, session 2	1110.36	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Locomotion distance, session 2	258.11	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Locomotion velocity, session 3	507.49	1	1	16.7	0	1.00e+00	Retreg2
Locomotion distance, session 3	4009.46	1	1	16.7	0	1.00e+00	Retreg2
Stereotopy head waving bouts, day 3	691.91	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Stereotopy head waving duration, day 3	1446.08	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Locomotion velocity, session 7	210.64	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Locomotion distance, session 7	507.07	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Stereotopy head waving bouts, day 7	2509.72	1	1	16.7	0	1.00e+00	Retreg2
Stereotopy head waving duration, day 7	2115.93	1	1	16.7	0	1.00e+00	Retreg2
Locomotion velocity, session 8	409.23	1	1	16.7	0	1.00e+00	Retreg2
Locomotion distance, session 8	147.88	1	1	16.7	0	1.00e+00	Retreg2
Degree of sensitization distance	1889.61	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Degree of sensitization stereotypy	1027.5	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. active minus inactive responses	484.11	2	1	16.7	0	1.00e+00	Mindy4b Retreg2
Condit. Reinf. active-inactive response ratio	126.1	2	1	16.7	0	1.00e+00	Mindy4b Retreg2
Condit. Reinf. active responses	1386.69	2	1	16.7	0	1.00e+00	Mindy4b Retreg2
Condit. Reinf. inactive responses	2347.96	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Incentive salience index mean	1780.77	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. lever presses	2666.81	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Time in familiar zone, hab. session 1	3732.01	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Time in novel zone, hab. session 1	4629.95	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Total zone transitions, hab. session 1	429.72	1	1	16.7	0	1.00e+00	Retreg2
Total locomotion distance, hab. session 1	394.1	1	1	16.7	0	1.00e+00	Retreg2
Locomotion velocity, hab. session 1	266.96	1	1	16.7	0	1.00e+00	Retreg2
Time in familiar zone, hab. session 2	2966.16	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Time in novel zone, hab. session 2	3208.33	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Total zone transitions, hab. session 2	38.53	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Total locomotion distance, hab. session 2	14.23	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Locomotion velocity, hab. session 2	31.27	1	1	16.7	0	1.00e+00	Retreg2
Novel to familiar place preference ratio	7678.6	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Novelty place preference	7474.7	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Time in novel zone, NPP test	5350.34	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Total zone transitions, NPP test	1935.62	1	1	16.7	0	1.00e+00	Retreg2
Total locomotion distance, NPP test	1687.31	1	1	16.7	0	1.00e+00	Retreg2
Locomotion velocity, NPP test	953.07	1	1	16.7	0	1.00e+00	Retreg2
Pavlov. Cond. lever latency	276.98	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. change in total contacts	522.83	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. index score	214.07	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. latency score	224.45	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever contacts	372.95	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. magazine entry number	250.94	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. intertrial magazine entries	82.71	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever-magazine prob. diff.	223.77	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. response bias	303.26	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: apparent density	5461.77	1	1	16.7	0	1.00e+00	Retreg2
Bone surface	3109.3	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone volume	4317.38	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Bone: connectivity density	838.02	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Bone: cortical apparent density	12020.36	1	1	16.7	0	1.00e+00	Retreg2
Bone: cortical area	2335.88	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: cortical porosity	220.21	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Bone: cortical porosity	1113.18	1	1	16.7	0	1.00e+00	Retreg2
Bone: cortical thickness	232.49	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: cortical thickness	1488.54	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: cortical tissue density	13002.58	1	1	16.7	0	1.00e+00	Retreg2
Bone: elastic displacement	3805.7	1	1	16.7	0	1.00e+00	Retreg2
Bone: elastic work	195.81	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: endosteal estimation	4459.49	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Bone: endosteal perimeter	5936.33	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Bone: final force	840.18	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: final moment	146.88	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: marrow area	4718.94	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Bone: maximum diameter	3067.59	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: maximum force	4390.32	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: maximum moment	3034.59	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: minimum diameter	2061.38	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: periosteal estimation	4919.52	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: periosteal perimeter	5722.93	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: post-yield work	4563.91	3	1	16.7	0	1.00e+00	Mindy4b Mst1 Retreg2
Bone: stiffness	4554.23	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: tissue strength	2995.95	1	1	16.7	0	1.00e+00	Retreg2
Bone: trabecular number	10739.78	1	1	16.7	0	1.00e+00	Retreg2
Bone: trabecular spacing	3991.76	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: trabecular thickness	4257.4	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Bone: trabecular tissue density	7288.79	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Breakpoint value in progressive ratio session	9415.11	3	2	33.3	1	2.43e-04	LOC108348573 Mst1 Retreg2
Distance traveled before self-admin	16853.09	2	1	16.7	0	1.00e+00	Foxred1 Retreg2
Distance traveled after self-admin	16241.13	2	1	16.7	0	1.00e+00	Foxred1 Retreg2
Delta time in closed arm before/after self-admin	93.84	3	1	16.7	0	1.00e+00	Foxred1 Mst1 Retreg2
Delta time in open arm before/after self-admin	5050.83	2	1	16.7	0	1.00e+00	Mst1 Retreg2
Diff in mean of infusions in LGA sessions	12228.05	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Extinction: sum of active levers before priming	4751.87	6	3	50	1	2.36e-06	Foxred1 LOC108348573 Mindy4b Mst1 Pus3 Retreg2
Active lever presses in extinction session 6	261.41	3	2	33.3	0	1.00e+00	Foxred1 Mst1 Retreg2
Delta distance traveled before/after self-admin	985.14	2	1	16.7	0	1.00e+00	Foxred1 Retreg2
Delta ambulatory time before/after self-admin	10295.59	2	1	16.7	0	1.00e+00	Foxred1 Retreg2
Time in closed arm before self-admin	8973.75	3	2	33.3	0	1.00e+00	Foxred1 Mst1 Retreg2
Time in closed arm after self-admin	2326.29	2	2	33.3	0	1.00e+00	Mst1 Retreg2
Time in open arm before self-admin	2193.22	3	1	16.7	-1	2.71e-03	Mindy4b Mst1 Retreg2
Time in open arm after self-admin	187.77	3	2	33.3	0	1.00e+00	Foxred1 Mst1 Retreg2
Sum of active levers in priming session hrs 5-6	505.81	2	2	33.3	0	1.00e+00	LOC108348573 Retreg2
Time to tail flick, vehicle, before self-admin	3352.8	4	2	33.3	1	8.62e-04	Foxred1 Mindy4b Mst1 Retreg2
Time to tail flick, vehicle, after self-admin	10546.69	3	1	16.7	1	8.30e-05	Foxred1 Mindy4b Retreg2
Time to tail flick, test, before self-admin	2041.17	4	1	16.7	-1	3.88e-03	Foxred1 LOC108348573 Mst1 Retreg2
Time to tail flick, test, after self-admin	364.71	4	2	33.3	0.97	2.60e-02	Foxred1 LOC108348573 Mindy4b Retreg2
Delta time to tail flick, vehicle, before/after SA	1977.17	4	2	33.3	0.99	4.94e-04	LOC108348573 Mindy4b Mst1 Retreg2
Delta time to tail flick, test, before/after SA	5240.92	3	2	33.3	0	1.00e+00	Mindy4b Mst1 Retreg2
Ambulatory time before self-admin	19733.43	3	2	33.3	1	8.29e-04	Foxred1 LOC108348573 Retreg2
Ambulatory time after self-admin	8878.72	3	1	16.7	0	1.00e+00	LOC108348573 Mst1 Retreg2
Total heroin consumption	74.17	4	2	33.3	0.89	1.07e-01	Foxred1 LOC108348573 Pus3 Retreg2
Area under the delay curve	6208.61	3	2	33.3	-1	2.66e-04	LOC108348573 Mindy4b Retreg2
Delay disc. indifference point, 0s delay	727.11	3	1	16.7	0	1.00e+00	LOC108348573 Mindy4b Retreg2
Delay disc. indifference point, 16s delay	7325.9	3	1	16.7	0	1.00e+00	LOC108348573 Mindy4b Retreg2
Delay disc. indifference point, 2s delay	59.14	3	1	16.7	0	1.00e+00	LOC108348573 Mindy4b Retreg2
Delay disc. indifference point, 24s delay	16232.11	2	2	33.3	0	1.00e+00	LOC108348573 Retreg2
Delay disc. indifference point, 4s delay	162.74	4	1	16.7	-0.97	2.73e-02	LOC108348573 Mindy4b Mst1 Retreg2
Delay disc. indifference point, 8s delay	11128.39	2	1	16.7	0	1.00e+00	LOC108348573 Retreg2
Delay discount exponential model param	4241.03	3	2	33.3	1	4.64e-04	LOC108348573 Mindy4b Retreg2
Delay discount hyperbolic model param	3079.67	3	1	16.7	1	7.32e-04	LOC108348573 Mindy4b Retreg2
Fecal boli incidents, locomotor time 1	30605.7	1	1	16.7	0	1.00e+00	Retreg2
Change in fecal boli incidents, locomotor task	2842.13	2	1	16.7	0	1.00e+00	Mindy4b Retreg2
Time >=10cm from walls, locomotor time 1	4347.19	2	1	16.7	0	1.00e+00	Mindy4b Retreg2
Bouts of movement, locomotor time 1	10785.17	1	1	16.7	0	1.00e+00	Retreg2
Total resting periods, locomotor time 1	2793.59	1	1	16.7	0	1.00e+00	Retreg2
Rest time, locomotor task time 1	22349.64	1	1	16.7	0	1.00e+00	Retreg2
Distance moved, locomotor task time 1	34417.38	1	1	16.7	0	1.00e+00	Retreg2
Vertical activity count, locomotor time 1	71190.42	1	1	16.7	0	1.00e+00	Retreg2
Time >=10cm from walls, locomotor time 2	23732.72	2	2	33.3	0	1.00e+00	Mindy4b Retreg2
Bouts of movement, locomotor time 2	20515.74	3	1	16.7	1	1.36e-04	Foxred1 Mindy4b Retreg2
Total resting periods, locomotor time 2	24767.91	3	1	16.7	1	1.25e-04	Foxred1 Mindy4b Retreg2
Rest time, locomotor task time 2	12754.88	1	1	16.7	0	1.00e+00	Retreg2
Distance moved, locomotor task time 2	4245.69	2	1	16.7	0	1.00e+00	Mindy4b Retreg2
Vertical activity count, locomotor time 2	26790.07	2	2	33.3	0	1.00e+00	Mindy4b Retreg2
Weight adjusted by age	35394.44	1	1	16.7	0	1.00e+00	Retreg2
Seeking ratio, delayed vs. immediate footshock	6730.03	2	1	16.7	0	1.00e+00	Mindy4b Retreg2
Locomotion in novel chamber	1955.3	2	1	16.7	0	1.00e+00	LOC108348573 Retreg2
Locomotion in novel chamber post-restriction	21812.12	2	1	16.7	0	1.00e+00	Mindy4b Retreg2
Progressive ratio	22633.47	2	1	16.7	0	1.00e+00	LOC108348573 Retreg2
Food seeking constrained by brief footshock	1875.34	1	1	16.7	0	1.00e+00	Retreg2
Seeking ratio, punishment vs. effort	20644.58	2	1	16.7	0	1.00e+00	LOC108348573 Retreg2
Run reversals in cocaine runway, females	2364.26	4	1	16.7	-1	4.12e-03	Foxred1 LOC108348573 Pus3 Retreg2
Run reversals in cocaine runway, males	2562.87	3	1	16.7	0	1.00e+00	Foxred1 Pus3 Retreg2
Latency to leave start box in cocaine runway	16290.75	1	1	16.7	0	1.00e+00	Retreg2
Latency to leave start box in cocaine runway, F	3588.04	2	1	16.7	0	1.00e+00	Mindy4b Retreg2
Latency to leave start box in cocaine runway, M	863.23	2	1	16.7	0	1.00e+00	Foxred1 Retreg2
Co content in liver	1133.25	1	1	16.7	0	1.00e+00	Retreg2
Cu content in liver	39.92	1	1	16.7	0	1.00e+00	Retreg2
Fe content in liver	1344.53	1	1	16.7	0	1.00e+00	Retreg2
K content in liver	1519.62	1	1	16.7	0	1.00e+00	Retreg2
Mg content in liver	6026.97	1	1	16.7	0	1.00e+00	Retreg2
Mn content in liver	1009.39	1	1	16.7	0	1.00e+00	Retreg2
Na content in liver	4018.36	1	1	16.7	0	1.00e+00	Retreg2
Rb content in liver	87.87	1	1	16.7	0	1.00e+00	Retreg2
Zn content in liver	3745.55	1	1	16.7	0	1.00e+00	Retreg2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.06
Adipose	alternative TSS	0	0	1
Adipose	gene expression	1	0	1.07
Adipose	isoform ratio	0	0	0.99
Adipose	intron excision ratio	0	0	0.97
Adipose	mRNA stability	1	0	1.06
BLA	alternative polyA	0	0	1.02
BLA	alternative TSS	0	0	1.04
BLA	gene expression	0	0	1.07
BLA	isoform ratio	0	0	1.04
BLA	intron excision ratio	0	0	0.99
BLA	mRNA stability	0	0	1.07
Brain	alternative polyA	0	0	1.01
Brain	alternative TSS	0	0	1.05
Brain	gene expression	0	0	1.07
Brain	isoform ratio	0	0	1.05
Brain	intron excision ratio	0	0	1.04
Brain	mRNA stability	0	0	1.04
Eye	alternative polyA	0	0	1.08
Eye	alternative TSS	0	0	1.28
Eye	gene expression	0	0	1.1
Eye	isoform ratio	0	0	1.02
Eye	intron excision ratio	0	0	1.07
Eye	mRNA stability	0	0	1.11
IC	alternative polyA	0	0	0.98
IC	alternative TSS	0	0	1.04
IC	gene expression	0	0	1.1
IC	isoform ratio	0	0	1
IC	intron excision ratio	0	0	0.97
IC	mRNA stability	0	0	1.06
IL	alternative polyA	0	0	0.97
IL	alternative TSS	0	0	1.15
IL	gene expression	0	0	1.08
IL	isoform ratio	0	0	1.04
IL	intron excision ratio	0	0	0.91
IL	mRNA stability	0	0	1.05
LHb	alternative polyA	0	0	0.93
LHb	alternative TSS	0	0	1.07
LHb	gene expression	0	0	1.06
LHb	isoform ratio	0	0	0.97
LHb	intron excision ratio	0	0	1
LHb	mRNA stability	0	0	1.09
Liver	alternative polyA	0	0	1.09
Liver	alternative TSS	0	0	1.01
Liver	gene expression	0	0	1.06
Liver	isoform ratio	1	0	1.04
Liver	intron excision ratio	0	0	0.99
Liver	mRNA stability	0	0	1.05
NAcc	alternative polyA	2	0.1	74.53
NAcc	alternative TSS	0	0	1.06
NAcc	gene expression	0	0	1.08
NAcc	isoform ratio	0	0	1.03
NAcc	intron excision ratio	2	0	1.05
NAcc	mRNA stability	0	0	1.1
OFC	alternative polyA	0	0	1.03
OFC	alternative TSS	0	0	1.17
OFC	gene expression	0	0	1.09
OFC	isoform ratio	0	0	1.01
OFC	intron excision ratio	0	0	1.01
OFC	mRNA stability	0	0	1.05
PL	alternative polyA	0	0	1.01
PL	alternative TSS	0	0	1.09
PL	gene expression	0	0	1.1
PL	isoform ratio	0	0	1.05
PL	intron excision ratio	0	0	1
PL	mRNA stability	0	0	1.06
pVTA	alternative polyA	0	0	1.04
pVTA	alternative TSS	0	0	1.02
pVTA	gene expression	0	0	1.05
pVTA	isoform ratio	0	0	1.03
pVTA	intron excision ratio	0	0	1.01
pVTA	mRNA stability	0	0	1.05
RMTg	alternative polyA	0	0	0.97
RMTg	alternative TSS	0	0	0.97
RMTg	gene expression	0	0	1.03
RMTg	isoform ratio	0	0	0.96
RMTg	intron excision ratio	0	0	0.94
RMTg	mRNA stability	0	0	1.02