Hub : Traits

Intermittent access intake escalation

Intermittent access day 15 minus day 1 infusions

Tags: Behavior · Intermittent access · Cocaine

Project: p50_paul_meyer_2020

3 loci · 3 genes with independent associations · 4 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr8	33211184	34601262	2	1	1.94e-10	1.22e-02	7.66e-04	Ddx25
2	chr8	86716032	88108158	1	1	1.86e-07	6.94e-03	2.50e-05	Ube3d
3	chr9	75969545	77365260	1	1	6.65e-27	4.49e-02	1.00e+00	Zfand2b

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	8.42	1	1	33.3	0	1.00e+00	Zfand2b
BMI without tail	21.85	3	1	33.3	0	1.00e+00	Ddx25 Pus3 Zfand2b
Epididymis fat weight	111.28	1	1	33.3	0	1.00e+00	Zfand2b
Heart weight	71.7	1	1	33.3	0	1.00e+00	Zfand2b
Left kidney weight	27.22	1	1	33.3	0	1.00e+00	Zfand2b
Right kidney weight	30	2	1	33.3	0	1.00e+00	Pus3 Zfand2b
Tail length	45.03	3	1	33.3	0	1.00e+00	Ddx25 Pus3 Zfand2b
Length with tail	4.78	1	0	0	0	1.00e+00	Zfand2b
Length without tail	41.28	2	1	33.3	0	1.00e+00	Ddx25 Zfand2b
Liver weight, right	17.57	1	1	33.3	0	1.00e+00	Zfand2b
Parametrial fat weight	8.07	2	0	0	0	1.00e+00	Pus3 Zfand2b
Retroperitoneal fat weight	7.53	1	0	0	0	1.00e+00	Zfand2b
Intraocular pressure	51.69	1	1	33.3	0	1.00e+00	Zfand2b
Extensor digitorum longus weight	2.63	1	0	0	0	1.00e+00	Pus3
Soleus weight	4.97	1	0	0	0	1.00e+00	Pus3
Tibialis anterior weight	2.34	2	0	0	0	1.00e+00	Pus3 Ube3d
Number of licking bursts	32.5	1	1	33.3	0	1.00e+00	Zfand2b
Food consumed during 24 hour testing period	15.78	1	0	0	0	1.00e+00	Zfand2b
Times rat made contact with spout	9.25	1	0	0	0	1.00e+00	Zfand2b
Mean time between licks in bursts	9.22	1	0	0	0	1.00e+00	Zfand2b
Mean num. licks in bursts	12.71	2	0	0	0	1.00e+00	Ube3d Zfand2b
Std. dev. time between licks in bursts	12.12	1	0	0	0	1.00e+00	Zfand2b
Water consumed over 24 hours	34.33	1	1	33.3	0	1.00e+00	Zfand2b
Patch foraging indifference point 0 sec	8.34	2	0	0	0	1.00e+00	Pus3 Zfand2b
Patch foraging indifference point AUC	24.2	1	1	33.3	0	1.00e+00	Zfand2b
Indifference point function ln k	54.42	1	1	33.3	0	1.00e+00	Zfand2b
Indifference point function log k	54.42	1	1	33.3	0	1.00e+00	Zfand2b
Patch foraging total patch changes 0 sec	14.23	2	1	33.3	0	1.00e+00	Pus3 Zfand2b
Patch foraging total patch changes 18 sec	48.28	1	1	33.3	0	1.00e+00	Zfand2b
Patch foraging total patch changes 24 sec	77.61	1	1	33.3	0	1.00e+00	Zfand2b
Patch foraging total patch changes 6 sec	24.67	1	1	33.3	0	1.00e+00	Zfand2b
Patch foraging time to switch 0 sec	33.47	1	1	33.3	0	1.00e+00	Zfand2b
Patch foraging water rate 0 sec	39.47	1	1	33.3	0	1.00e+00	Zfand2b
Patch foraging water rate 12 sec	69.49	1	1	33.3	0	1.00e+00	Zfand2b
Patch foraging water rate 18 sec	9.71	1	0	0	0	1.00e+00	Zfand2b
Patch foraging water rate 24 sec	12.61	1	0	0	0	1.00e+00	Zfand2b
Patch foraging water rate 6 sec	35.43	1	1	33.3	0	1.00e+00	Zfand2b
Locomotor activity	8.43	2	0	0	0	1.00e+00	Ddx25 Zfand2b
Locomotor testing distance	25.97	2	1	33.3	0	1.00e+00	Ddx25 Zfand2b
Locomotor testing rearing	99.51	1	1	33.3	0	1.00e+00	Zfand2b
Light reinforcement 1	19.25	1	1	33.3	0	1.00e+00	Zfand2b
Light reinforcement 2	6.57	1	0	0	0	1.00e+00	Zfand2b
Reaction time number correct	114.79	1	1	33.3	0	1.00e+00	Zfand2b
Reaction time mean minus median	179.03	1	1	33.3	0	1.00e+00	Zfand2b
Reaction time mean minus median AUC	232.47	1	1	33.3	0	1.00e+00	Zfand2b
Reaction time num false alarms	5.7	1	0	0	0	1.00e+00	Zfand2b
Reaction time num false alarms AUC	27.43	1	1	33.3	0	1.00e+00	Zfand2b
Reaction time trials correct on left	114.79	1	1	33.3	0	1.00e+00	Zfand2b
Reaction time trials on left	106.69	1	1	33.3	0	1.00e+00	Zfand2b
Reaction time mean	20.45	2	1	33.3	0	1.00e+00	Ddx25 Zfand2b
Reaction time mean AUC	33.75	1	1	33.3	0	1.00e+00	Zfand2b
Median of all reaction times	17.65	1	0	0	0	1.00e+00	Zfand2b
Reaction time omissions	46.56	1	1	33.3	0	1.00e+00	Zfand2b
Reaction time premature initiations	41.6	1	1	33.3	0	1.00e+00	Zfand2b
Std. dev. reaction times	72.92	1	1	33.3	0	1.00e+00	Zfand2b
Reaction time trials completed	106.69	1	1	33.3	0	1.00e+00	Zfand2b
Reaction time trials AUC	108.76	1	1	33.3	0	1.00e+00	Zfand2b
Social response proportion	6.01	1	0	0	0	1.00e+00	Zfand2b
Cocaine response after cond. corrected	12.71	1	0	0	0	1.00e+00	Zfand2b
Cocaine response after cond. not corrected	10.73	1	0	0	0	1.00e+00	Zfand2b
Saline control response	8.43	1	0	0	0	1.00e+00	Zfand2b
Condit. Reinf. lever presses	5.55	1	0	0	0	1.00e+00	Zfand2b
Conditioned reinforcement - actives	152.54	1	1	33.3	0	1.00e+00	Zfand2b
Conditioned reinforcement - inactives	75.29	2	1	33.3	0	1.00e+00	Ddx25 Zfand2b
Conditioned locomotion	13.93	1	0	0	0	1.00e+00	Zfand2b
Intermittent access intake day 1-15 change	76.82	4	3	100	1	2.15e-03	Ddx25 Pus3 Ube3d Zfand2b
Intermittent access intake escalation 2	25.26	3	1	33.3	0	1.00e+00	Ddx25 Pus3 Ube3d
Intermitt. access day 1 inactive lever presses	67.74	3	2	66.7	0	1.00e+00	Ddx25 Pus3 Zfand2b
Intermitt. access day 15 inactive lever presses	117	3	2	66.7	0	1.00e+00	Ddx25 Pus3 Zfand2b
Intermitt. access escalation Index	14.59	1	0	0	0	1.00e+00	Ddx25
Intermittent access day 1 total infusions	71.42	1	1	33.3	0	1.00e+00	Zfand2b
Intermittent access day 15 total infusions	27.57	4	2	66.7	0.94	5.55e-02	Ddx25 Pus3 Ube3d Zfand2b
Intermittent access terminal intake (last 3 days)	24.67	4	2	66.7	0.91	8.66e-02	Ddx25 Pus3 Ube3d Zfand2b
Intermittent access total infusions	16.77	2	1	33.3	0	1.00e+00	Ddx25 Pus3
Intermittent access day 1 locomotion	26.47	1	1	33.3	0	1.00e+00	Zfand2b
Intermittent access day 15 total locomotion	93.08	1	1	33.3	0	1.00e+00	Zfand2b
Intermittent access total locomotion	12.43	1	0	0	0	1.00e+00	Zfand2b
Intermittent access standard deviation	118.95	4	1	33.3	0.83	1.67e-01	Ddx25 Pus3 Ube3d Zfand2b
Cocaine induced anxiety	47.82	3	1	33.3	0	1.00e+00	Ddx25 Pus3 Zfand2b
Baseline Anxiety	393.92	1	1	33.3	0	1.00e+00	Zfand2b
Lifetime Intake	29.19	2	1	33.3	0	1.00e+00	Ddx25 Pus3
Incentive Sensitization - Responses	87.93	4	1	33.3	-0.33	6.70e-01	Ddx25 Pus3 Ube3d Zfand2b
Incentive Sensitization - Breakpoint	86.22	4	1	33.3	-0.32	6.76e-01	Ddx25 Pus3 Ube3d Zfand2b
Progressive ratio test 1 active lever presses	17.67	2	1	33.3	0	1.00e+00	Ddx25 Zfand2b
Progressive ratio test 1 breakpoint	13.02	2	0	0	0	1.00e+00	Ddx25 Zfand2b
Progressive ratio test 1 inactive lever presses	13.22	2	0	0	0	1.00e+00	Ddx25 Ube3d
Progressive ratio test 2 active lever presses	43.65	3	1	33.3	0	1.00e+00	Ddx25 Pus3 Zfand2b
Progressive ratio test 2 breakpoint	44.41	3	1	33.3	0	1.00e+00	Ddx25 Pus3 Zfand2b
Progressive ratio test 2 inactive lever presses	38.78	3	2	66.7	0	1.00e+00	Ddx25 Pus3 Zfand2b
Total sessions with >9 infusions	14.48	2	0	0	0	1.00e+00	Ddx25 Ube3d
Short access day 1 total inactive lever presses	21.93	1	0	0	0	1.00e+00	Zfand2b
Short access day 10 total inactive lever presses	43.04	1	1	33.3	0	1.00e+00	Zfand2b
Short access day 1 total infusions	27.95	3	1	33.3	0	1.00e+00	Ddx25 Pus3 Ube3d
Short access day 10 total infusions	20.98	2	1	33.3	0	1.00e+00	Ddx25 Pus3
Short access total infusions	37.49	2	1	33.3	0	1.00e+00	Ddx25 Pus3
Short access day 1 locomotion	68.85	2	1	33.3	0	1.00e+00	Ube3d Zfand2b
Short access day 10 total locomotion	114.32	4	1	33.3	0.44	5.57e-01	Ddx25 Pus3 Ube3d Zfand2b
Short access total locomotion	209.96	1	1	33.3	0	1.00e+00	Zfand2b
Compulsive drug intake	68.39	1	1	33.3	0	1.00e+00	Zfand2b
One hour access (0.3 mA shock)	40.41	3	2	66.7	0	1.00e+00	Ddx25 Pus3 Zfand2b
One hour access (shock baseline)	27.52	2	1	33.3	0	1.00e+00	Ddx25 Pus3
Number of responses in last shaping day	35.12	3	2	66.7	0	1.00e+00	Ddx25 Pus3 Zfand2b
Degree of sensitization distance	7.96	1	0	0	0	1.00e+00	Ube3d
Condit. Reinf. active-inactive response ratio	6.71	1	0	0	0	1.00e+00	Ube3d
Time in familiar zone, hab. session 2	8.51	1	0	0	0	1.00e+00	Ube3d
Novel to familiar place preference ratio	6.13	1	0	0	0	1.00e+00	Ube3d
Pavlov. Cond. lever latency	7.89	1	0	0	0	1.00e+00	Ube3d
Pavlov. Cond. lever contacts	6.57	1	0	0	0	1.00e+00	Ube3d
Bone: cortical area	6.36	2	0	0	0	1.00e+00	Ddx25 Pus3
Bone: cortical thickness	4.39	1	0	0	0	1.00e+00	Ddx25
Bone: cortical thickness	5.77	1	0	0	0	1.00e+00	Ddx25
Bone: elastic displacement	5.56	1	0	0	0	1.00e+00	Zfand2b
Bone: final force	5.29	1	0	0	0	1.00e+00	Ddx25
Bone: final moment	4.65	1	0	0	0	1.00e+00	Ddx25
Bone: maximum force	6.75	1	0	0	0	1.00e+00	Ddx25
Bone: maximum moment	5.84	1	0	0	0	1.00e+00	Ddx25
Bone: minimum diameter	4.04	2	0	0	0	1.00e+00	Ddx25 Pus3
Bone: periosteal estimation	3.75	1	0	0	0	1.00e+00	Ddx25
Bone: stiffness	4.98	1	0	0	0	1.00e+00	Ddx25
Bone: trabecular tissue density	6.5	1	0	0	0	1.00e+00	Ube3d
Distance traveled before self-admin	11.43	2	0	0	0	1.00e+00	Ddx25 Pus3
Distance traveled after self-admin	10.47	2	0	0	0	1.00e+00	Ddx25 Zfand2b
Delta time in open arm before/after self-admin	26.67	1	0	0	0	1.00e+00	Zfand2b
Extinction: sum of active levers before priming	15.52	2	0	0	0	1.00e+00	Ddx25 Pus3
Active lever presses in extinction session 6	14.73	3	0	0	0	1.00e+00	Ddx25 Pus3 Zfand2b
Delta distance traveled before/after self-admin	6.76	1	0	0	0	1.00e+00	Ddx25
Delta ambulatory time before/after self-admin	9.98	3	0	0	0	1.00e+00	Ddx25 Pus3 Zfand2b
Time in closed arm before self-admin	25.58	2	1	33.3	0	1.00e+00	Ube3d Zfand2b
Time in open arm before self-admin	24.67	1	0	0	0	1.00e+00	Zfand2b
Sum of active levers in priming session hrs 5-6	6.97	1	0	0	0	1.00e+00	Zfand2b
Time to tail flick, vehicle, before self-admin	9.26	1	0	0	0	1.00e+00	Ddx25
Time to tail flick, vehicle, after self-admin	75.62	1	1	33.3	0	1.00e+00	Zfand2b
Time to tail flick, test, before self-admin	10.68	1	0	0	0	1.00e+00	Zfand2b
Delta time to tail flick, vehicle, before/after SA	74.6	1	1	33.3	0	1.00e+00	Zfand2b
Ambulatory time before self-admin	21.89	3	1	33.3	0	1.00e+00	Ddx25 Pus3 Zfand2b
Total heroin consumption	10.44	2	0	0	0	1.00e+00	Ddx25 Pus3
Area under the delay curve	31.15	1	1	33.3	0	1.00e+00	Zfand2b
Delay disc. indifference point, 0s delay	5.71	1	0	0	0	1.00e+00	Zfand2b
Delay disc. indifference point, 16s delay	69.03	1	1	33.3	0	1.00e+00	Zfand2b
Delay disc. indifference point, 24s delay	27.43	1	0	0	0	1.00e+00	Zfand2b
Delay disc. indifference point, 8s delay	74.24	1	1	33.3	0	1.00e+00	Zfand2b
Delay discount exponential model param	16.14	1	0	0	0	1.00e+00	Zfand2b
Delay discount hyperbolic model param	15.89	1	0	0	0	1.00e+00	Zfand2b
Fecal boli incidents, locomotor time 1	176.47	1	1	33.3	0	1.00e+00	Zfand2b
Time >=10cm from walls, locomotor time 1	79.04	1	1	33.3	0	1.00e+00	Zfand2b
Bouts of movement, locomotor time 1	5.98	2	0	0	0	1.00e+00	Ube3d Zfand2b
Total resting periods, locomotor time 1	6.63	1	0	0	0	1.00e+00	Ube3d
Rest time, locomotor task time 1	11.47	1	0	0	0	1.00e+00	Zfand2b
Distance moved, locomotor task time 1	19.24	1	0	0	0	1.00e+00	Ube3d
Vertical activity count, locomotor time 1	56.1	2	1	33.3	0	1.00e+00	Ube3d Zfand2b
Bouts of movement, locomotor time 2	14.99	2	0	0	0	1.00e+00	Ube3d Zfand2b
Total resting periods, locomotor time 2	21.88	2	1	33.3	0	1.00e+00	Ube3d Zfand2b
Rest time, locomotor task time 2	44.91	1	1	33.3	0	1.00e+00	Zfand2b
Distance moved, locomotor task time 2	45.13	2	1	33.3	0	1.00e+00	Ube3d Zfand2b
Vertical activity count, locomotor time 2	10.53	2	0	0	0	1.00e+00	Ube3d Zfand2b
Weight adjusted by age	9.91	1	0	0	0	1.00e+00	Zfand2b
Seeking ratio, delayed vs. immediate footshock	8.74	1	0	0	0	1.00e+00	Zfand2b
Locomotion in novel chamber post-restriction	14.04	1	0	0	0	1.00e+00	Zfand2b
Food seeking constrained by brief footshock	14.98	1	0	0	0	1.00e+00	Zfand2b
Run reversals in cocaine runway, females	36.45	1	1	33.3	0	1.00e+00	Zfand2b
Run reversals in cocaine runway, males	7.73	2	0	0	0	1.00e+00	Ddx25 Pus3
Latency to leave start box in cocaine runway	20.07	2	1	33.3	0	1.00e+00	Ddx25 Zfand2b
Latency to leave start box in cocaine runway, F	31.9	1	1	33.3	0	1.00e+00	Zfand2b
Latency to leave start box in cocaine runway, M	10.69	2	0	0	0	1.00e+00	Ddx25 Pus3
Cd content in liver	6.54	1	0	0	0	1.00e+00	Ube3d
Fe content in liver	8.46	1	0	0	0	1.00e+00	Pus3
Na content in liver	12.89	1	0	0	0	1.00e+00	Ube3d
Sr content in liver	9.74	1	0	0	0	1.00e+00	Ddx25

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.01
Adipose	alternative TSS	0	0	1.02
Adipose	gene expression	1	0	1
Adipose	isoform ratio	0	0	0.95
Adipose	intron excision ratio	0	0	0.88
Adipose	mRNA stability	1	0	0.98
BLA	alternative polyA	0	0	1.04
BLA	alternative TSS	0	0	0.99
BLA	gene expression	0	0	1.01
BLA	isoform ratio	0	0	0.98
BLA	intron excision ratio	0	0	0.91
BLA	mRNA stability	0	0	0.99
Brain	alternative polyA	0	0	0.96
Brain	alternative TSS	0	0	0.99
Brain	gene expression	0	0	1.01
Brain	isoform ratio	0	0	0.98
Brain	intron excision ratio	0	0	0.94
Brain	mRNA stability	0	0	0.99
Eye	alternative polyA	0	0	0.93
Eye	alternative TSS	0	0	1.14
Eye	gene expression	0	0	0.98
Eye	isoform ratio	0	0	1.14
Eye	intron excision ratio	0	0	0.97
Eye	mRNA stability	0	0	1.11
IL	alternative polyA	0	0	0.9
IL	alternative TSS	0	0	0.92
IL	gene expression	0	0	0.99
IL	isoform ratio	0	0	1.01
IL	intron excision ratio	0	0	0.91
IL	mRNA stability	0	0	0.96
LHb	alternative polyA	0	0	0.97
LHb	alternative TSS	0	0	1.05
LHb	gene expression	0	0	0.99
LHb	isoform ratio	0	0	0.96
LHb	intron excision ratio	0	0	0.85
LHb	mRNA stability	0	0	1.01
Liver	alternative polyA	0	0	1
Liver	alternative TSS	0	0	0.97
Liver	gene expression	0	0	0.98
Liver	isoform ratio	0	0	0.99
Liver	intron excision ratio	0	0	0.92
Liver	mRNA stability	0	0	0.98
NAcc	alternative polyA	0	0	0.99
NAcc	alternative TSS	0	0	1.03
NAcc	gene expression	0	0	1.01
NAcc	isoform ratio	0	0	1.03
NAcc	intron excision ratio	0	0	0.94
NAcc	mRNA stability	0	0	1.05
OFC	alternative polyA	0	0	0.97
OFC	alternative TSS	0	0	1.09
OFC	gene expression	0	0	1.02
OFC	isoform ratio	0	0	1.03
OFC	intron excision ratio	0	0	0.89
OFC	mRNA stability	0	0	0.98
PL	alternative polyA	0	0	0.96
PL	alternative TSS	0	0	1.01
PL	gene expression	0	0	1.03
PL	isoform ratio	0	0	0.99
PL	intron excision ratio	1	0	0.95
PL	mRNA stability	0	0	1
pVTA	alternative polyA	1	0.1	1
pVTA	alternative TSS	0	0	0.99
pVTA	gene expression	0	0	1
pVTA	isoform ratio	0	0	0.97
pVTA	intron excision ratio	0	0	0.93
pVTA	mRNA stability	0	0	1.02
RMTg	alternative polyA	0	0	1.05
RMTg	alternative TSS	0	0	1.02
RMTg	gene expression	0	0	1.02
RMTg	isoform ratio	0	0	0.98
RMTg	intron excision ratio	0	0	0.9
RMTg	mRNA stability	0	0	0.98