Hub : Genes

Nemp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000012924 0.05 0.04 1.1e-03 0 0.01 0.03 0.01 8.9e-02 9.0e-03 1.9e-04 1.2e-02
2 Adipose mRNA stability ENSRNOG00000012924 0.04 0.03 2.6e-03 0.01 0 0.01 0.01 6.5e-02 1.7e-01 5.4e-02 2.5e-02
3 Brain gene expression ENSRNOG00000012924 0.03 0.02 6.6e-03 0.01 0.01 0 0.01 5.2e-02 6.1e-02 1.1e-01 5.6e-02
4 Brain intron excision ratio chr9:48867039:48869817 0.03 0.03 4.0e-03 0.02 0.02 0.01 0.02 2.2e-03 3.3e-03 1.3e-02 9.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail4.414.319.53.52.74.3-4.4
BMI without tail1.22.53.81.60.81.7-2.0
Body weight0.20.82.8-0.61.70.1-0.3
Epididymis fat weight0.61.52.6-1.60.9-1.11.1
Glucose0.71.12.01.40.11.0-1.0
Heart weight0.40.50.6-0.7-0.6-0.80.8
Left kidney weight0.10.30.7-0.80.8-0.2-0.0
Right kidney weight0.30.92.5-0.71.60.3-0.5
Tail length3.29.612.9-3.5-0.9-3.63.5
Length with tail3.613.119.5-4.4-0.4-4.14.0
Length without tail0.71.63.5-1.91.3-0.70.9
Liver weight, left0.10.20.8-0.90.2-0.20.2
Liver weight, right0.30.40.9-1.00.6-0.40.4
Parametrial fat weight0.10.20.50.00.70.4-0.4
Retroperitoneal fat weight0.30.92.9-0.81.70.0-0.1
Intraocular pressure0.20.30.60.80.40.5-0.7
Extensor digitorum longus weight3.815.327.40.75.24.1-4.1
Soleus weight0.30.92.1-0.51.40.8-0.8
Tibialis anterior weight2.27.710.41.52.83.2-3.2
Tibia length4.011.315.0-3.9-1.1-3.83.8
Number of licking bursts0.50.61.51.2-0.70.5-0.5
Food consumed during 24 hour testing period0.50.61.1-1.0-0.3-0.80.8
Times rat made contact with spout0.60.71.41.2-1.10.3-0.3
Mean time between licks in bursts0.81.11.40.41.11.2-1.2
Mean num. licks in bursts0.00.00.1-0.30.1-0.00.0
Std. dev. time between licks in bursts4.55.37.12.01.72.7-2.7
Water consumed over 24 hours0.80.91.21.00.31.1-1.1
Indifference point 0 sec2.94.76.52.5-0.12.4-2.5
Indifference point AUC0.10.10.20.4-0.50.3-0.3
Indifference point function ln k0.81.12.11.40.11.1-1.1
Indifference point function log k0.81.12.11.40.11.1-1.1
Delay discounting total patch changes 0 sec3.04.86.62.6-0.32.5-2.5
Delay discounting total patch changes 12 sec0.30.40.60.8-0.40.6-0.7
Delay discounting total patch changes 18 sec1.52.03.21.8-0.51.5-1.5
Delay discounting total patch changes 24 sec0.81.01.81.3-0.61.0-1.0
Delay discounting total patch changes 6 sec2.53.85.22.2-0.22.2-2.3
Delay discounting time to switch 0 sec0.50.81.1-1.0-0.3-1.11.1
Delay discounting water rate 0 sec0.61.01.50.70.71.2-1.2
Delay discounting water rate 12 sec0.40.61.01.00.00.9-0.8
Delay discounting water rate 18 sec0.00.10.20.40.00.1-0.1
Delay discounting water rate 24 sec0.30.31.0-0.61.0-0.10.1
Delay discounting water rate 6 sec1.01.42.51.60.11.3-1.2
Locomotor activity0.00.00.10.2-0.00.1-0.1
Locomotor testing distance0.40.61.90.7-1.4-0.20.2
Locomotor testing rearing0.50.71.71.3-0.10.8-0.8
Light reinforcement 12.75.06.71.42.12.6-2.6
Light reinforcement 20.40.60.90.60.40.9-0.9
Reaction time number correct1.11.62.00.81.31.4-1.4
Reaction time mean minus median2.12.73.3-1.1-1.8-1.81.8
Reaction time mean minus median AUC1.31.72.1-0.9-1.4-1.41.4
Reaction time num false alarms3.44.77.70.72.82.3-2.3
Reaction time num false alarms AUC3.24.46.60.82.62.3-2.3
Reaction time trials correct on left1.11.62.00.81.31.4-1.4
Reaction time trials on left1.01.51.80.81.31.3-1.3
Reaction time mean5.77.811.2-2.6-1.4-3.33.4
Reaction time mean AUC4.96.59.5-2.4-1.3-3.03.1
Median of all reaction times5.47.310.7-2.7-0.9-3.23.3
Reaction time omissions0.10.20.4-0.2-0.2-0.60.6
Reaction time false alarm rate1.21.72.80.41.71.4-1.4
Reaction time premature initiation rate0.00.00.00.2-0.1-0.20.1
Reaction time premature initiations0.20.30.40.50.60.5-0.6
Std. dev. reaction times5.17.09.2-2.1-2.3-3.03.0
Reaction time trials completed1.01.51.80.81.31.3-1.3
Reaction time trials AUC1.01.41.80.81.21.3-1.3
Social response proportion0.50.50.8-0.9-0.1-0.70.8
Social responses0.10.20.5-0.50.70.1-0.0
Social time0.30.40.8-0.2-0.9-0.70.7
Conditioned locomotion0.20.20.5-0.40.7-0.20.2
Cocaine response after cond. corrected0.91.02.5-1.21.6-0.10.1
Cocaine response after cond. not corrected1.92.14.4-2.11.3-1.11.1
Cocaine response before conditioning0.91.11.4-1.1-0.5-1.21.2
Saline control response0.40.51.01.0-0.90.4-0.4
Condit. Reinf. active minus inactive responses3.34.15.7-2.0-0.8-2.42.4
Condit. Reinf. active-inactive response ratio2.82.94.0-1.3-1.4-2.02.0
Condit. Reinf. active responses1.01.32.0-1.40.1-1.31.3
Condit. Reinf. inactive responses0.10.20.5-0.40.70.1-0.1
Condit. Reinf. lever presses0.10.10.2-0.3-0.3-0.40.4
Condit. Reinf. lever reinforcers received1.01.42.2-1.50.3-1.21.2
Pavlov. Cond. lever latency0.30.40.60.40.70.7-0.7
Pavlov. Cond. magazine entry latency0.40.40.5-0.6-0.6-0.70.7
Pavlov. Cond. change in total contacts1.11.52.0-0.8-1.4-1.31.3
Pavlov. Cond. index score0.81.01.3-0.9-0.9-1.11.1
Pavlov. Cond. latency score0.81.01.3-0.9-0.8-1.11.1
Pavlov. Cond. lever contacts0.60.91.5-0.5-1.2-1.01.0
Pavlov. Cond. magazine entry number0.91.21.60.61.31.1-1.1
Pavlov. Cond. intertrial magazine entries0.91.21.50.81.11.2-1.2
Pavlov. Cond. lever-magazine prob. diff.0.50.60.8-0.7-0.7-0.90.9
Pavlov. Cond. response bias1.21.61.9-1.0-1.4-1.41.4
Conditioned reinforcement - actives0.20.20.4-0.6-0.3-0.50.5
Conditioned reinforcement - inactives1.01.21.7-1.0-0.5-1.21.3
Conditioned locomotion1.31.52.50.31.21.6-1.4
Intermittent access intake day 1-15 change0.60.61.01.00.40.7-0.7
Intermittent access intake escalation0.20.20.40.50.60.3-0.3
Intermittent access intake escalation 20.10.10.20.50.20.1-0.1
Intermitt. access day 1 inactive lever presses0.30.30.40.5-0.50.6-0.6
Intermitt. access day 15 inactive lever presses0.50.50.7-0.6-0.6-0.80.9
Intermitt. access escalation Index1.00.91.60.61.30.9-0.9
Intermittent access day 1 total infusions0.40.50.8-0.1-0.9-0.70.8
Intermittent access day 15 total infusions0.10.10.50.7-0.20.0-0.0
Intermittent access terminal intake (last 3 days)0.30.31.01.0-0.20.4-0.3
Intermittent access total infusions0.20.30.60.3-0.8-0.40.5
Intermittent access day 1 locomotion0.10.10.1-0.0-0.3-0.10.3
Intermittent access day 15 total locomotion0.00.00.1-0.20.1-0.00.2
Intermittent access total locomotion0.10.10.20.40.00.4-0.3
Intermittent access standard deviation0.10.10.20.5-0.10.2-0.2
Cocaine induced anxiety3.33.87.10.72.71.9-1.9
Post-drug Anxiety2.12.35.00.52.21.4-1.4
Baseline Anxiety1.92.02.8-0.7-1.7-1.61.6
Lifetime Intake0.10.10.10.3-0.4-0.20.3
Incentive Sensitization - Responses0.30.30.5-0.60.1-0.70.7
Incentive Sensitization - Breakpoint0.20.20.3-0.50.2-0.50.5
Progressive ratio test 1 active lever presses0.00.00.10.00.30.1-0.0
Progressive ratio test 1 breakpoint0.00.00.00.10.10.2-0.1
Progressive ratio test 1 inactive lever presses0.00.00.0-0.20.10.1-0.0
Progressive ratio test 2 active lever presses0.20.20.4-0.30.0-0.60.6
Progressive ratio test 2 breakpoint0.00.00.00.20.0-0.10.2
Progressive ratio test 2 inactive lever presses0.10.20.3-0.3-0.3-0.50.5
Total sessions with >9 infusions0.60.72.1-0.41.40.5-0.4
Short access day 1 total inactive lever presses0.10.10.1-0.30.10.3-0.3
Short access day 10 total inactive lever presses0.40.40.7-0.8-0.2-0.70.7
Short access day 1 total infusions0.10.10.30.0-0.5-0.10.1
Short access day 10 total infusions0.10.10.40.6-0.5-0.00.1
Short access total infusions0.00.00.10.30.10.2-0.1
Short access day 1 locomotion0.00.00.1-0.20.10.2-0.1
Short access day 10 total locomotion0.30.30.6-0.80.4-0.50.6
Short access total locomotion0.30.30.8-0.60.90.3-0.2
Compulsive drug intake0.10.10.20.30.40.4-0.4
One hour access (0.3 mA shock)0.10.20.30.1-0.3-0.50.6
One hour access (shock baseline)0.30.30.5-0.0-0.6-0.60.7
Number of responses in last shaping day0.10.10.20.30.40.4-0.4
Context. condit. distance diff. score1.41.73.11.80.31.3-1.3
Locomotion velocity, session 10.10.10.30.10.50.2-0.2
Locomotion distance, session 10.20.30.70.10.80.5-0.5
Locomotion velocity, session 21.31.52.00.51.41.4-1.4
Locomotion distance, session 20.40.61.00.11.00.9-0.9
Locomotion velocity, session 30.20.20.20.40.30.5-0.5
Locomotion distance, session 30.60.61.31.2-0.30.7-0.7
Stereotopy head waving bouts, day 30.40.50.80.30.90.7-0.7
Stereotopy head waving duration, day 30.10.10.4-0.10.70.2-0.2
Locomotion velocity, session 70.40.41.2-0.71.10.2-0.2
Locomotion distance, session 70.60.82.4-0.71.60.4-0.4
Stereotopy head waving bouts, day 70.10.10.2-0.2-0.1-0.40.4
Stereotopy head waving duration, day 70.50.60.9-0.6-0.5-0.90.9
Locomotion velocity, session 80.50.61.21.1-0.30.7-0.7
Locomotion distance, session 81.32.02.61.60.51.6-1.6
Degree of sensitization distance1.21.22.6-1.61.3-0.50.5
Degree of sensitization stereotypy0.30.30.70.1-0.8-0.50.5
Condit. Reinf. active minus inactive responses3.94.46.3-2.2-0.5-2.52.5
Condit. Reinf. active-inactive response ratio2.22.43.4-1.6-0.1-1.81.8
Condit. Reinf. active responses3.64.46.0-2.4-0.1-2.42.4
Condit. Reinf. inactive responses0.40.50.9-1.00.9-0.30.3
Incentive salience index mean2.83.34.9-1.6-1.0-2.22.2
Condit. Reinf. lever presses0.40.60.8-0.2-0.9-0.90.9
Time in familiar zone, hab. session 10.50.50.60.80.50.7-0.7
Time in novel zone, hab. session 13.13.03.9-1.1-1.7-2.02.0
Total zone transitions, hab. session 10.20.40.9-1.00.1-0.50.5
Total locomotion distance, hab. session 11.42.04.7-2.20.4-1.31.3
Locomotion velocity, hab. session 10.60.82.3-1.50.7-0.50.5
Time in familiar zone, hab. session 20.00.00.10.3-0.30.0-0.0
Time in novel zone, hab. session 20.00.00.10.2-0.00.1-0.1
Total zone transitions, hab. session 20.00.00.10.3-0.10.2-0.2
Total locomotion distance, hab. session 20.50.71.5-1.20.5-0.80.8
Locomotion velocity, hab. session 20.50.71.5-1.20.7-0.60.6
Novel to familiar place preference ratio1.31.41.7-0.6-1.3-1.31.3
Novelty place preference0.91.01.7-0.3-1.3-1.01.0
Time in novel zone, NPP test1.11.11.9-0.3-1.4-1.11.1
Total zone transitions, NPP test0.50.71.70.21.30.7-0.7
Total locomotion distance, NPP test0.20.30.6-0.8-0.0-0.50.5
Locomotion velocity, NPP test0.00.10.2-0.40.1-0.10.1
Pavlov. Cond. lever latency1.72.12.80.71.51.7-1.7
Pavlov. Cond. magazine entry latency2.02.63.7-1.3-1.0-1.91.9
Pavlov. Cond. change in total contacts1.21.32.0-0.9-0.5-1.41.4
Pavlov. Cond. index score1.62.02.6-0.5-1.6-1.61.6
Pavlov. Cond. latency score1.72.22.9-0.7-1.6-1.71.7
Pavlov. Cond. lever contacts0.81.02.20.1-1.5-0.90.9
Pavlov. Cond. magazine entry number3.13.95.61.31.62.4-2.4
Pavlov. Cond. intertrial magazine entries0.30.31.1-0.31.00.1-0.1
Pavlov. Cond. lever-magazine prob. diff.1.31.62.1-0.5-1.4-1.51.5
Pavlov. Cond. response bias1.41.72.2-0.5-1.4-1.51.5
Bone: apparent density2.44.07.6-0.6-2.8-2.02.0
Bone surface0.81.31.5-1.0-1.2-1.21.2
Bone volume2.03.44.2-1.2-2.0-2.02.0
Bone: connectivity density0.50.82.40.1-1.6-0.60.6
Bone: cortical apparent density5.67.29.21.72.73.0-3.0
Bone: cortical area0.30.40.9-0.90.9-0.10.1
Bone: cortical porosity1.82.04.5-0.3-2.1-1.31.3
Bone: cortical porosity2.32.54.7-0.7-2.2-1.61.6
Bone: cortical thickness1.11.82.30.81.31.5-1.5
Bone: cortical thickness0.10.10.2-0.40.1-0.20.2
Bone: cortical tissue density5.57.19.11.72.73.0-3.0
Bone: elastic displacement0.60.71.91.0-1.4-0.00.0
Bone: elastic work1.31.72.3-1.0-1.1-1.51.5
Bone: endosteal estimation3.47.49.7-3.1-1.1-3.13.1
Bone: endosteal perimeter1.63.25.2-2.3-0.1-2.02.0
Bone: final force1.11.83.9-2.00.6-1.21.2
Bone: final moment0.61.02.4-1.60.6-0.80.8
Bone: marrow area3.27.09.2-3.0-1.0-3.03.0
Bone: maximum diameter0.10.20.4-0.60.6-0.10.1
Bone: maximum force2.13.66.6-2.6-0.1-2.02.0
Bone: maximum moment1.32.34.3-2.1-0.1-1.51.5
Bone: minimum diameter0.71.32.8-1.70.2-1.01.0
Bone: periosteal estimation2.04.06.5-2.5-0.3-2.22.2
Bone: periosteal perimeter0.91.52.6-1.60.1-1.31.3
Bone: post-yield work1.31.83.0-1.7-0.2-1.51.5
Bone: stiffness1.93.16.5-2.60.6-1.71.7
Bone: tissue strength0.00.00.0-0.1-0.00.0-0.0
Bone: trabecular number1.21.82.8-0.7-1.7-1.41.4
Bone: trabecular spacing0.81.13.5-0.61.90.4-0.4
Bone: trabecular thickness3.34.08.0-0.4-2.8-2.02.0
Bone: trabecular tissue density0.50.71.2-1.10.9-0.60.6
Breakpoint value in progressive ratio session0.60.70.9-0.90.4-0.90.9
Distance traveled before self-admin5.05.46.8-2.4-1.6-2.52.6
Distance traveled after self-admin1.11.22.0-1.4-0.1-1.11.2
Delta time in closed arm before/after self-admin0.60.50.70.40.80.8-0.9
Delta time in open arm before/after self-admin3.02.93.8-0.9-2.0-1.81.9
Diff in mean of infusions in LGA sessions1.11.22.0-0.8-0.7-1.31.4
Extinction: sum of active levers before priming1.31.31.8-1.30.0-1.31.3
Active lever presses in extinction session 60.20.20.4-0.2-0.2-0.60.6
Delta distance traveled before/after self-admin1.21.22.00.61.41.1-1.2
Delta ambulatory time before/after self-admin1.31.52.50.71.61.1-1.3
Time in closed arm before self-admin2.52.83.4-1.1-1.8-1.81.9
Time in closed arm after self-admin0.20.20.3-0.5-0.3-0.60.5
Time in open arm before self-admin2.83.06.50.52.61.6-1.6
Time in open arm after self-admin1.92.13.0-1.2-1.0-1.71.7
Sum of active levers in priming session hrs 5-61.91.92.7-1.50.4-1.61.6
Time to tail flick, vehicle, before self-admin0.60.60.90.90.40.9-0.9
Time to tail flick, vehicle, after self-admin0.20.20.4-0.30.1-0.60.4
Time to tail flick, test, before self-admin1.51.53.30.11.81.2-1.1
Time to tail flick, test, after self-admin1.41.42.30.70.81.5-1.5
Delta time to tail flick, vehicle, before/after SA0.90.81.4-0.8-0.4-1.21.0
Delta time to tail flick, test, before/after SA0.90.82.40.9-1.50.2-0.3
Ambulatory time before self-admin3.94.15.3-2.2-1.3-2.22.3
Ambulatory time after self-admin0.20.30.6-0.80.4-0.30.3
Total heroin consumption0.60.71.5-0.0-1.2-0.70.8
Area under the delay curve0.00.00.0-0.10.2-0.10.0
Delay disc. indifference point, 0s delay0.20.20.60.3-0.8-0.10.1
Delay disc. indifference point, 16s delay0.40.40.7-0.7-0.1-0.80.8
Delay disc. indifference point, 2s delay0.00.10.20.1-0.4-0.10.0
Delay disc. indifference point, 24s delay0.10.10.10.30.40.2-0.2
Delay disc. indifference point, 4s delay0.20.20.40.40.30.6-0.6
Delay disc. indifference point, 8s delay0.40.50.7-0.90.3-0.80.7
Delay discount exponential model param0.00.00.0-0.0-0.20.10.0
Delay discount hyperbolic model param0.00.00.1-0.1-0.2-0.10.2
Fecal boli incidents, locomotor time 10.10.10.20.5-0.30.2-0.3
Change in fecal boli incidents, locomotor task0.00.00.10.20.00.2-0.2
Time >=10cm from walls, locomotor time 10.40.41.0-0.91.0-0.10.0
Bouts of movement, locomotor time 11.01.11.61.10.51.3-1.2
Total resting periods, locomotor time 11.31.52.21.10.71.5-1.4
Rest time, locomotor task time 10.80.91.51.2-0.31.0-0.9
Distance moved, locomotor task time 10.50.50.9-0.91.0-0.50.5
Vertical activity count, locomotor time 10.20.20.4-0.50.6-0.20.1
Time >=10cm from walls, locomotor time 21.21.31.8-0.5-1.2-1.31.2
Bouts of movement, locomotor time 23.13.44.11.22.02.0-2.0
Total resting periods, locomotor time 23.03.24.21.41.62.0-2.1
Rest time, locomotor task time 21.51.73.01.7-0.61.3-1.3
Distance moved, locomotor task time 20.91.11.8-1.40.7-1.11.0
Vertical activity count, locomotor time 20.20.20.6-0.20.80.0-0.1
Weight adjusted by age0.80.92.0-1.40.7-0.60.8
Seeking ratio, delayed vs. immediate footshock2.02.33.3-1.5-0.9-1.71.8
Locomotion in novel chamber1.01.32.9-0.01.71.1-1.1
Locomotion in novel chamber post-restriction0.60.81.5-0.31.20.9-0.8
Progressive ratio0.91.03.5-0.61.90.2-0.2
Food seeking constrained by brief footshock0.40.51.5-0.81.2-0.10.0
Seeking ratio, punishment vs. effort0.10.20.7-0.0-0.8-0.20.2
Run reversals in cocaine runway, females0.40.41.0-0.61.00.1-0.1
Run reversals in cocaine runway, males0.90.92.4-0.21.50.8-0.8
Latency to leave start box in cocaine runway5.05.47.92.11.22.8-2.8
Latency to leave start box in cocaine runway, F3.74.05.42.3-0.22.3-2.3
Latency to leave start box in cocaine runway, M2.42.35.7-0.12.41.3-1.3
Cd content in liver1.01.12.1-1.50.3-1.01.0
Co content in liver0.20.20.40.2-0.6-0.50.5
Cu content in liver1.61.92.9-1.0-0.9-1.71.7
Fe content in liver2.42.84.1-1.2-1.3-2.02.0
K content in liver0.70.71.00.9-0.21.0-1.0
Mg content in liver0.80.81.11.1-0.11.0-1.0
Mn content in liver1.01.22.21.5-1.10.8-0.8
Na content in liver0.20.20.40.6-0.50.3-0.3
Rb content in liver1.31.64.7-0.42.20.9-0.9
Se content in liver0.10.10.10.3-0.30.3-0.3
Sr content in liver0.20.20.20.30.50.4-0.4
Zn content in liver0.60.60.80.50.90.9-0.9