Arhgap27

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000028569	0.19	0.08	0.0e+00	0.15	0.12	0.14	0.1	1.0e-16	9.6e-13	4.0e-15	3.4e-11
2	BLA	gene expression	ENSRNOG00000028569	0.07	0.04	1.5e-03	0.03	0.05	0.03	0.03	6.7e-03	1.7e-03	7.5e-03	7.8e-03
3	Brain	alternative TSS	ENSRNOT00000038836	0.13	0.07	1.7e-06	0.07	0.07	0.07	0.07	3.1e-07	5.4e-07	7.8e-07	4.9e-07
4	Brain	alternative TSS	ENSRNOT00000119071	0.12	0.06	3.6e-06	0.07	0.07	0.07	0.07	5.0e-07	9.8e-07	1.0e-06	6.5e-07
5	OFC	gene expression	ENSRNOG00000028569	0.17	0.1	5.9e-03	0.01	0.07	0.06	0.04	1.6e-01	9.9e-03	1.2e-02	4.4e-02
6	PL	gene expression	ENSRNOG00000028569	0.13	0.07	2.0e-07	0.08	0.08	0.06	0.09	2.2e-06	7.7e-07	1.1e-05	2.7e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
BMI with tail	1.1	3.5	8.7	-0.8	-0.7	3.0	-2.9	-0.5	-1.5
BMI without tail	0.1	0.3	0.5	0.1	0.5	0.7	-0.7	0.5	-0.4
Body weight	0.6	2.5	3.5	1.3	1.9	1.7	-1.7	1.8	0.9
Epididymis fat weight	0.1	0.3	0.7	0.4	0.8	0.5	-0.6	0.6	0.6
Glucose	1.0	1.6	1.8	-1.3	-1.3	1.2	-1.2	-1.2	-1.3
Heart weight	0.7	1.0	1.7	0.6	0.9	1.3	-1.3	0.7	0.9
Left kidney weight	0.1	0.4	0.8	0.3	0.5	0.7	-0.7	0.9	0.5
Right kidney weight	0.1	0.3	0.7	-0.2	0.2	0.7	-0.8	0.8	0.0
Tail length	0.4	1.3	2.3	0.8	1.5	-0.9	0.9	1.2	1.3
Length with tail	0.8	3.1	5.8	1.7	2.4	-0.2	0.2	2.3	2.1
Length without tail	0.7	1.6	3.6	1.4	1.5	0.2	-0.2	1.9	1.2
Liver weight, left	0.6	1.0	1.4	1.0	0.9	-1.0	1.0	1.2	0.7
Liver weight, right	0.3	0.5	1.5	-0.7	-0.5	-0.5	0.5	0.7	-1.2
Parametrial fat weight	1.0	1.9	5.0	1.4	1.6	-0.9	0.8	2.2	0.8
Retroperitoneal fat weight	0.3	1.1	2.7	0.8	1.4	-0.5	0.4	1.7	0.7
Intraocular pressure	0.2	0.2	0.5	-0.2	-0.1	0.7	-0.7	-0.7	0.3
Extensor digitorum longus weight	4.5	18.0	26.7	-3.6	-3.5	5.1	-5.2	-4.7	-2.6
Soleus weight	0.1	0.2	0.6	-0.1	0.1	0.8	-0.8	-0.1	0.4
Tibialis anterior weight	0.3	0.9	1.9	-0.4	-0.2	1.4	-1.4	-1.1	0.3
Tibia length	0.4	1.1	2.2	-0.7	-0.2	1.1	-1.1	1.1	-1.5
Number of licking bursts	0.8	1.0	1.7	-1.0	-0.6	1.3	-1.3	-1.0	-0.2
Food consumed during 24 hour testing period	0.2	0.2	0.3	-0.2	0.5	0.6	-0.6	0.2	0.5
Times rat made contact with spout	0.1	0.1	0.4	-0.7	0.1	0.0	-0.0	0.4	-0.2
Mean time between licks in bursts	1.7	2.4	5.9	-0.9	-0.8	2.4	-2.4	-0.8	-0.6
Mean num. licks in bursts	0.4	0.5	1.1	0.5	0.6	-0.8	0.8	1.0	0.0
Std. dev. time between licks in bursts	0.5	0.6	1.4	-0.2	-0.4	1.2	-1.2	-0.8	-0.2
Water consumed over 24 hours	0.3	0.3	1.1	-1.0	-0.4	-0.1	0.1	0.3	-0.7
Indifference point 0 sec	1.6	2.6	4.3	1.7	1.7	-1.6	1.6	2.1	0.6
Indifference point AUC	0.2	0.3	0.7	0.7	0.7	0.1	-0.1	-0.0	0.8
Indifference point function ln k	1.1	1.5	2.4	0.8	1.0	-1.5	1.5	1.5	0.8
Indifference point function log k	1.1	1.5	2.4	0.8	1.0	-1.5	1.5	1.5	0.8
Delay discounting total patch changes 0 sec	2.1	3.5	6.3	2.0	2.0	-1.7	1.7	2.5	0.8
Delay discounting total patch changes 12 sec	1.7	2.2	3.6	1.9	1.7	-1.4	1.4	1.4	1.0
Delay discounting total patch changes 18 sec	0.5	0.7	1.6	1.3	1.0	-0.3	0.3	1.0	0.6
Delay discounting total patch changes 24 sec	2.1	2.6	4.5	1.9	1.7	-1.4	1.4	2.1	0.8
Delay discounting total patch changes 6 sec	0.6	0.9	1.7	1.2	1.1	-0.7	0.7	1.3	0.4
Delay discounting time to switch 0 sec	0.1	0.2	0.4	-0.2	-0.4	0.4	-0.4	-0.6	-0.1
Delay discounting water rate 0 sec	0.1	0.2	1.1	0.3	0.5	-0.1	0.0	1.0	-0.1
Delay discounting water rate 12 sec	0.2	0.3	0.6	-0.7	-0.7	0.0	-0.0	0.3	-0.8
Delay discounting water rate 18 sec	0.6	0.8	1.3	-0.1	-0.1	-1.1	1.2	1.1	-0.9
Delay discounting water rate 24 sec	0.4	0.5	1.3	-0.6	-0.8	-0.5	0.6	0.1	-1.2
Delay discounting water rate 6 sec	0.8	1.2	2.2	0.8	0.9	-1.1	1.1	1.5	0.8
Locomotor activity	2.0	3.1	4.4	2.0	2.0	-1.5	1.6	1.3	2.1
Locomotor testing distance	3.4	5.7	9.0	3.0	2.7	-1.8	1.8	1.6	2.9
Locomotor testing rearing	1.1	1.7	3.2	1.7	1.5	-0.9	0.9	0.4	1.8
Light reinforcement 1	1.4	2.5	2.9	1.7	1.6	-1.7	1.7	1.7	1.2
Light reinforcement 2	1.6	2.1	2.7	1.5	1.4	-1.5	1.5	1.6	1.1
Reaction time number correct	0.0	0.0	0.1	-0.3	-0.0	0.2	-0.2	0.0	0.2
Reaction time mean minus median	0.3	0.4	0.7	0.3	0.5	-0.8	0.8	0.3	0.7
Reaction time mean minus median AUC	0.6	0.8	2.3	-0.1	0.1	-1.5	1.5	0.2	0.3
Reaction time num false alarms	0.7	0.9	1.8	0.9	1.4	0.1	-0.1	1.2	1.2
Reaction time num false alarms AUC	1.0	1.3	2.5	1.2	1.6	-0.2	0.2	1.5	1.4
Reaction time trials correct on left	0.0	0.0	0.1	-0.3	-0.0	0.2	-0.2	0.0	0.2
Reaction time trials on left	0.0	0.0	0.1	-0.2	0.0	0.0	-0.0	0.1	0.3
Reaction time mean	0.7	1.0	2.8	0.4	0.3	-1.7	1.6	0.1	0.6
Reaction time mean AUC	0.6	0.8	2.4	0.1	0.1	-1.5	1.5	-0.2	0.5
Median of all reaction times	0.9	1.2	3.1	0.5	0.4	-1.8	1.8	0.1	0.7
Reaction time omissions	4.8	6.4	10.4	1.9	2.1	-3.2	3.2	2.3	2.1
Reaction time false alarm rate	0.6	0.9	1.8	1.1	1.3	-0.2	0.2	1.2	1.0
Reaction time premature initiation rate	0.9	1.2	2.3	1.5	1.4	-0.3	0.2	1.5	0.8
Reaction time premature initiations	0.8	1.2	2.1	1.4	1.4	-0.2	0.2	1.4	0.9
Std. dev. reaction times	0.8	1.0	3.1	0.1	0.3	-1.7	1.7	0.2	0.4
Reaction time trials completed	0.0	0.0	0.1	-0.2	0.0	0.0	-0.0	0.1	0.3
Reaction time trials AUC	0.0	0.0	0.1	-0.3	-0.0	-0.0	-0.0	0.0	0.3
Social response proportion	0.3	0.4	0.8	-0.2	0.4	0.8	-0.9	0.1	0.7
Social responses	0.2	0.3	0.7	0.4	0.8	-0.2	0.2	0.8	0.6
Social time	1.0	1.3	3.7	1.3	1.3	-0.1	0.1	0.8	1.9
Conditioned locomotion	0.0	0.0	0.2	-0.0	-0.1	0.1	-0.1	-0.2	-0.4
Cocaine response after cond. corrected	0.2	0.2	0.8	-0.0	-0.0	0.0	-0.0	0.9	-0.5
Cocaine response after cond. not corrected	0.6	0.6	1.9	0.1	0.3	-0.9	0.9	1.4	-0.2
Cocaine response before conditioning	0.8	0.9	2.1	0.3	0.5	-1.5	1.5	0.7	0.6
Saline control response	0.1	0.2	0.3	0.6	0.6	0.3	-0.3	-0.1	0.3
Condit. Reinf. active minus inactive responses	4.5	5.6	6.8	2.6	2.3	-2.3	2.3	2.1	2.6
Condit. Reinf. active-inactive response ratio	4.1	4.3	7.1	2.1	2.0	-2.0	2.0	1.5	2.7
Condit. Reinf. active responses	4.8	6.7	8.0	2.8	2.6	-2.6	2.6	2.0	2.8
Condit. Reinf. inactive responses	0.9	1.2	1.9	1.0	1.0	-1.4	1.4	0.9	0.7
Condit. Reinf. lever presses	1.5	2.1	2.7	1.6	1.4	-1.6	1.6	1.0	1.4
Condit. Reinf. lever reinforcers received	3.8	5.4	6.2	2.5	2.3	-2.4	2.4	1.9	2.5
Pavlov. Cond. lever latency	0.5	0.7	1.1	-0.8	-0.6	1.1	-1.1	-0.5	-0.7
Pavlov. Cond. magazine entry latency	0.7	0.8	1.2	-0.9	-1.1	0.8	-0.8	-1.0	-0.7
Pavlov. Cond. change in total contacts	0.6	0.8	1.8	0.6	0.5	-1.0	1.0	-0.5	1.4
Pavlov. Cond. index score	0.1	0.2	0.4	0.3	0.1	-0.4	0.4	-0.1	0.6
Pavlov. Cond. latency score	0.2	0.2	0.6	0.4	0.3	-0.4	0.4	0.0	0.8
Pavlov. Cond. lever contacts	0.4	0.6	1.2	0.6	0.6	-1.1	1.1	0.5	0.6
Pavlov. Cond. magazine entry number	0.5	0.6	1.2	0.8	1.1	-0.4	0.4	0.9	0.9
Pavlov. Cond. intertrial magazine entries	4.1	5.3	8.7	2.5	2.9	-1.3	1.3	2.5	2.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	0.2	0.0	-0.3	0.3	-0.2	0.5
Pavlov. Cond. response bias	0.2	0.2	0.7	0.2	0.1	-0.8	0.8	0.2	0.1
Conditioned reinforcement - actives	0.2	0.2	0.7	0.4	0.5	0.2	-0.1	-0.3	0.8
Conditioned reinforcement - inactives	2.2	2.5	3.5	1.9	1.7	-1.4	1.5	1.7	1.2
Conditioned locomotion	0.7	0.8	1.6	1.2	1.1	0.1	-0.0	0.7	1.3
Intermittent access intake day 1-15 change	0.2	0.2	0.5	0.1	0.3	0.5	-0.5	0.7	-0.3
Intermittent access intake escalation	0.5	0.4	0.8	-0.6	-0.2	0.9	-0.9	0.3	-0.8
Intermittent access intake escalation 2	0.5	0.5	1.0	0.4	0.7	0.7	-0.8	1.0	-0.1
Intermitt. access day 1 inactive lever presses	5.2	5.6	8.1	2.8	2.8	-1.5	1.5	2.7	2.5
Intermitt. access day 15 inactive lever presses	7.1	7.8	9.3	2.9	2.6	-2.9	2.8	2.3	3.0
Intermitt. access escalation Index	0.8	0.7	1.3	-0.7	-0.8	0.9	-1.0	-1.1	-0.4
Intermittent access day 1 total infusions	0.2	0.2	0.5	0.3	0.3	0.6	-0.3	-0.2	0.7
Intermittent access day 15 total infusions	0.4	0.5	1.5	-0.2	0.0	1.2	-1.1	-0.1	-0.2
Intermittent access terminal intake (last 3 days)	0.3	0.4	0.6	0.7	0.8	0.5	-0.3	0.4	0.8
Intermittent access total infusions	0.3	0.3	0.9	0.2	0.5	0.9	-0.8	0.1	0.5
Intermittent access day 1 locomotion	1.0	1.0	1.8	1.3	1.3	0.3	-0.2	0.9	1.3
Intermittent access day 15 total locomotion	0.2	0.3	0.6	0.6	0.7	0.3	-0.2	0.7	0.3
Intermittent access total locomotion	1.3	1.5	2.9	1.4	1.7	0.2	-0.1	1.4	1.5
Intermittent access standard deviation	1.5	1.6	2.7	1.5	1.6	-0.8	0.9	1.7	0.8
Cocaine induced anxiety	0.2	0.3	1.3	-0.3	0.0	-0.1	0.1	1.1	-0.5
Post-drug Anxiety	0.3	0.3	0.8	-0.1	0.1	0.9	-0.9	0.7	0.2
Baseline Anxiety	0.1	0.1	0.3	0.3	-0.0	0.3	-0.4	-0.6	0.4
Lifetime Intake	0.7	0.7	1.5	1.0	1.2	0.1	-0.0	0.8	1.2
Incentive Sensitization - Responses	0.9	0.9	1.6	1.3	1.1	-0.7	0.7	0.7	1.1
Incentive Sensitization - Breakpoint	0.8	0.8	1.3	1.1	0.9	-0.8	0.7	0.7	1.0
Progressive ratio test 1 active lever presses	1.1	1.1	2.6	1.4	1.2	-0.4	0.5	0.5	1.6
Progressive ratio test 1 breakpoint	1.4	1.4	3.7	1.5	1.4	-0.4	0.5	0.5	1.9
Progressive ratio test 1 inactive lever presses	4.4	4.7	6.3	2.4	2.5	-1.8	1.9	2.0	2.4
Progressive ratio test 2 active lever presses	0.6	0.7	1.3	1.0	1.1	-0.2	0.3	0.6	1.1
Progressive ratio test 2 breakpoint	0.7	0.8	1.4	1.2	1.2	-0.2	0.3	0.7	1.2
Progressive ratio test 2 inactive lever presses	2.2	2.5	4.4	1.8	2.1	-0.8	0.8	1.7	1.9
Total sessions with >9 infusions	0.3	0.3	0.7	0.6	0.6	0.4	-0.3	-0.1	0.8
Short access day 1 total inactive lever presses	0.7	0.7	1.2	0.9	0.9	-0.6	0.6	0.9	1.1
Short access day 10 total inactive lever presses	3.2	3.6	6.2	2.2	2.5	-0.8	0.7	2.4	1.9
Short access day 1 total infusions	1.3	1.4	2.6	1.3	1.4	-0.9	1.0	0.7	1.6
Short access day 10 total infusions	1.9	2.0	3.9	1.6	1.8	-0.5	0.7	1.3	2.0
Short access total infusions	2.2	2.4	4.7	1.7	1.9	-0.8	0.9	1.3	2.2
Short access day 1 locomotion	2.3	2.5	3.6	1.9	1.9	-1.0	1.1	1.5	1.8
Short access day 10 total locomotion	5.7	6.2	11.1	3.1	3.3	-0.7	0.8	2.3	3.2
Short access total locomotion	4.0	4.0	8.6	2.5	2.6	-0.2	0.4	1.5	2.9
Compulsive drug intake	1.0	1.0	2.1	-1.3	-1.3	0.4	-0.5	-0.5	-1.5
One hour access (0.3 mA shock)	0.2	0.3	0.9	0.0	0.1	0.9	-0.8	0.0	0.1
One hour access (shock baseline)	0.5	0.6	1.0	0.5	0.7	1.0	-0.9	0.2	0.9
Number of responses in last shaping day	2.5	2.5	4.9	2.2	1.9	0.5	-0.4	1.7	1.8
Context. condit. distance diff. score	2.0	2.5	3.4	-1.6	-1.4	1.9	-1.9	-1.3	-1.4
Locomotion velocity, session 1	0.3	0.3	0.4	0.3	0.5	-0.6	0.6	0.6	0.5
Locomotion distance, session 1	0.1	0.1	0.2	0.3	0.3	-0.2	0.2	0.4	-0.0
Locomotion velocity, session 2	0.4	0.4	1.2	-0.1	-0.2	-1.1	1.1	0.3	-0.1
Locomotion distance, session 2	0.2	0.2	0.5	0.5	0.3	-0.7	0.7	0.3	0.1
Locomotion velocity, session 3	0.1	0.1	0.6	0.1	0.1	-0.0	0.0	0.8	-0.3
Locomotion distance, session 3	0.1	0.1	0.3	-0.2	-0.4	0.5	-0.5	0.0	-0.2
Stereotopy head waving bouts, day 3	0.2	0.3	1.1	-0.2	-0.4	-0.2	0.2	0.5	-1.1
Stereotopy head waving duration, day 3	0.2	0.3	1.0	-0.4	-0.6	0.1	-0.1	-0.2	-1.0
Locomotion velocity, session 7	0.8	0.9	1.8	-1.3	-1.1	0.7	-0.7	-0.4	-1.2
Locomotion distance, session 7	0.4	0.5	0.8	-0.8	-0.9	0.6	-0.6	-0.7	-0.7
Stereotopy head waving bouts, day 7	0.6	0.7	2.0	-0.3	-0.3	-1.4	1.4	0.4	-0.1
Stereotopy head waving duration, day 7	0.8	1.0	1.3	-1.1	-1.0	-1.1	1.1	-0.5	-0.9
Locomotion velocity, session 8	0.4	0.4	1.1	0.1	0.3	1.0	-1.0	0.3	-0.5
Locomotion distance, session 8	0.5	0.7	1.0	-0.9	-0.9	0.7	-0.7	-0.9	-1.0
Degree of sensitization distance	0.1	0.1	0.3	0.0	0.1	0.6	-0.6	-0.4	0.0
Degree of sensitization stereotypy	0.5	0.6	1.0	-0.9	-0.7	-1.0	1.0	-0.3	-0.4
Condit. Reinf. active minus inactive responses	0.8	0.9	2.3	1.1	1.0	-0.7	0.7	0.3	1.5
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.9	0.3	0.0	-0.3	0.3	-0.6	0.9
Condit. Reinf. active responses	1.0	1.3	2.2	1.5	1.3	-0.9	0.9	0.7	1.3
Condit. Reinf. inactive responses	1.1	1.3	2.7	1.4	1.3	-0.9	0.9	1.6	0.2
Incentive salience index mean	1.1	1.3	2.7	1.1	1.1	-1.1	1.1	0.6	1.6
Condit. Reinf. lever presses	0.3	0.4	0.5	0.5	0.6	-0.7	0.7	0.5	0.5
Time in familiar zone, hab. session 1	1.3	1.2	1.7	-0.8	-0.8	1.3	-1.3	-1.2	-1.0
Time in novel zone, hab. session 1	0.3	0.3	0.6	0.1	0.2	-0.8	0.8	0.7	0.6
Total zone transitions, hab. session 1	1.2	1.7	2.5	-1.4	-1.1	1.6	-1.6	-1.1	-0.9
Total locomotion distance, hab. session 1	0.3	0.5	1.2	0.8	0.8	-0.1	0.1	1.1	0.6
Locomotion velocity, hab. session 1	0.5	0.7	1.4	1.1	1.0	-0.1	0.1	1.2	0.8
Time in familiar zone, hab. session 2	1.1	1.1	2.2	-0.9	-0.5	1.5	-1.5	-0.9	-0.8
Time in novel zone, hab. session 2	1.2	1.2	2.4	0.8	0.4	-1.6	1.6	1.2	0.6
Total zone transitions, hab. session 2	2.0	2.6	4.1	-1.9	-1.7	1.3	-1.3	-2.0	-1.1
Total locomotion distance, hab. session 2	0.8	1.1	1.6	-1.3	-1.1	0.9	-0.9	-1.2	-0.9
Locomotion velocity, hab. session 2	0.9	1.2	1.6	-1.3	-1.2	1.0	-1.0	-1.2	-1.0
Novel to familiar place preference ratio	0.8	0.9	1.7	1.3	1.1	-0.4	0.4	1.2	0.7
Novelty place preference	0.8	0.8	1.4	1.2	1.0	-0.5	0.5	1.2	0.7
Time in novel zone, NPP test	0.7	0.7	1.4	1.0	0.8	-0.6	0.6	1.2	0.5
Total zone transitions, NPP test	1.0	1.5	2.3	-1.5	-1.5	0.7	-0.7	-1.2	-1.4
Total locomotion distance, NPP test	0.0	0.1	0.2	-0.2	-0.1	-0.2	0.2	0.4	-0.3
Locomotion velocity, NPP test	0.0	0.0	0.1	-0.1	-0.1	0.2	-0.2	0.1	-0.2
Pavlov. Cond. lever latency	3.6	4.6	6.3	-2.5	-2.4	1.3	-1.3	-2.5	-2.4
Pavlov. Cond. magazine entry latency	5.1	6.6	8.3	2.7	2.7	-2.4	2.4	2.9	2.1
Pavlov. Cond. change in total contacts	2.9	3.1	4.2	1.7	1.9	-1.7	1.7	1.5	2.1
Pavlov. Cond. index score	4.1	5.2	7.0	2.6	2.6	-1.7	1.7	2.6	2.3
Pavlov. Cond. latency score	3.6	4.6	6.1	2.5	2.5	-1.6	1.6	2.4	2.2
Pavlov. Cond. lever contacts	2.5	3.0	4.7	2.1	2.1	-0.8	0.8	1.8	2.2
Pavlov. Cond. magazine entry number	4.8	6.0	7.2	-2.4	-2.4	2.7	-2.7	-2.5	-1.9
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.0	0.0	0.1	1.0	-1.0	-0.7	-0.1
Pavlov. Cond. lever-magazine prob. diff.	4.5	5.6	7.1	2.7	2.6	-1.8	1.8	2.6	2.5
Pavlov. Cond. response bias	6.0	7.3	9.4	2.9	2.8	-2.5	2.5	3.1	2.4
Bone: apparent density	3.4	5.7	9.7	2.3	2.3	-2.4	2.4	3.1	1.6
Bone surface	6.7	11.8	17.3	3.9	3.6	-2.8	2.8	4.2	3.2
Bone volume	5.3	8.9	14.4	3.3	3.1	-2.5	2.5	3.8	2.5
Bone: connectivity density	4.5	7.1	8.8	2.7	2.5	-2.8	2.8	3.0	2.2
Bone: cortical apparent density	2.7	3.6	7.9	-2.1	-2.4	-0.6	0.6	-1.6	-2.8
Bone: cortical area	3.6	5.5	10.7	2.5	2.4	-1.9	1.9	3.3	1.6
Bone: cortical porosity	12.1	13.1	19.4	4.3	4.4	-1.6	1.6	4.4	4.0
Bone: cortical porosity	8.3	8.9	15.0	3.6	3.7	-1.0	1.0	3.9	3.2
Bone: cortical thickness	0.8	1.3	2.9	-0.1	-0.1	-1.5	1.5	1.7	-0.9
Bone: cortical thickness	1.5	1.7	4.6	0.1	-0.2	-2.1	2.1	1.1	-0.3
Bone: cortical tissue density	2.7	3.5	7.4	-2.1	-2.4	-0.6	0.6	-1.7	-2.7
Bone: elastic displacement	0.4	0.5	0.9	0.1	0.3	-1.0	1.0	0.9	0.3
Bone: elastic work	2.1	2.7	4.6	1.5	1.7	-1.5	1.5	2.1	1.5
Bone: endosteal estimation	3.5	7.5	13.9	3.7	3.4	-0.4	0.4	2.3	3.7
Bone: endosteal perimeter	5.0	10.2	18.0	4.2	4.1	-0.6	0.6	2.9	4.2
Bone: final force	2.5	4.1	8.3	2.0	1.8	-2.0	2.0	2.9	0.9
Bone: final moment	2.9	4.7	9.2	2.2	1.9	-2.2	2.2	3.0	1.1
Bone: marrow area	3.5	7.4	13.6	3.7	3.4	-0.4	0.4	2.4	3.7
Bone: maximum diameter	3.5	6.3	9.8	3.1	2.9	-1.7	1.7	3.0	2.3
Bone: maximum force	2.3	4.0	8.4	2.6	2.3	-1.0	1.0	2.9	1.4
Bone: maximum moment	2.6	4.5	9.2	2.6	2.3	-1.2	1.2	3.0	1.5
Bone: minimum diameter	7.0	12.9	21.1	4.6	4.4	-1.4	1.4	3.8	4.3
Bone: periosteal estimation	5.2	10.7	17.0	4.1	3.8	-1.7	1.7	3.8	3.5
Bone: periosteal perimeter	4.1	6.8	10.7	3.3	3.1	-1.0	1.0	2.9	3.1
Bone: post-yield work	1.8	2.4	3.2	1.8	1.6	1.4	-1.4	1.1	1.8
Bone: stiffness	0.2	0.2	0.4	0.7	0.4	0.5	-0.5	0.6	-0.2
Bone: tissue strength	0.6	0.6	2.1	-0.5	-0.5	0.7	-0.7	-0.1	-1.5
Bone: trabecular number	5.4	8.4	12.1	3.0	2.9	-2.8	2.8	3.5	2.3
Bone: trabecular spacing	2.7	3.5	4.8	-1.7	-1.5	2.2	-2.2	-2.1	-1.4
Bone: trabecular thickness	2.5	3.0	5.6	2.0	1.9	-1.1	1.1	2.4	1.7
Bone: trabecular tissue density	0.3	0.4	1.5	-0.6	-0.6	-0.2	0.2	0.2	-1.2
Breakpoint value in progressive ratio session	0.5	0.6	1.7	0.7	0.8	-0.6	0.6	-0.1	1.3
Distance traveled before self-admin	0.2	0.2	0.8	0.5	0.3	0.2	-0.2	-0.2	0.9
Distance traveled after self-admin	0.3	0.3	0.7	-0.0	-0.3	0.8	-0.9	-0.6	-0.1
Delta time in closed arm before/after self-admin	1.7	1.6	3.5	-1.4	-0.6	1.4	-1.4	0.3	-1.9
Delta time in open arm before/after self-admin	0.4	0.4	1.8	0.2	-0.2	-0.1	0.0	-1.3	0.6
Diff in mean of infusions in LGA sessions	0.3	0.3	0.9	0.7	0.8	-0.1	0.1	0.2	0.9
Extinction: sum of active levers before priming	0.1	0.1	0.4	-0.1	0.1	0.5	-0.6	-0.3	-0.0
Active lever presses in extinction session 6	2.1	2.0	4.7	1.7	1.8	-0.3	0.4	0.9	2.2
Delta distance traveled before/after self-admin	0.3	0.3	1.1	-0.5	-0.5	0.1	-0.2	-0.1	-1.1
Delta ambulatory time before/after self-admin	0.2	0.2	0.8	-0.2	-0.1	0.3	-0.4	0.3	-0.9
Time in closed arm before self-admin	1.3	1.5	3.3	-1.4	-1.4	-0.8	0.8	-0.8	-1.8
Time in closed arm after self-admin	4.1	4.3	11.4	-2.8	-2.1	0.8	-0.8	-0.9	-3.4
Time in open arm before self-admin	1.6	1.7	4.7	-0.5	-0.6	2.2	-2.1	-0.4	-0.3
Time in open arm after self-admin	1.6	1.7	4.6	1.6	1.2	1.0	-1.0	-0.1	2.1
Sum of active levers in priming session hrs 5-6	0.9	0.9	3.4	-0.9	-1.1	0.1	-0.1	-1.8	-0.0
Time to tail flick, vehicle, before self-admin	1.0	1.0	2.2	-1.2	-1.5	0.5	-0.5	-0.7	-1.1
Time to tail flick, vehicle, after self-admin	0.5	0.6	0.9	0.7	0.9	-0.6	0.7	0.5	0.9
Time to tail flick, test, before self-admin	2.6	2.6	4.2	-2.1	-1.8	1.1	-1.1	-2.0	-1.2
Time to tail flick, test, after self-admin	0.1	0.1	0.3	0.0	0.1	-0.3	0.3	-0.0	0.5
Delta time to tail flick, vehicle, before/after SA	3.2	3.2	4.7	2.0	2.2	-1.5	1.5	1.3	2.0
Delta time to tail flick, test, before/after SA	2.5	2.3	3.2	1.8	1.5	-1.3	1.3	1.3	1.7
Ambulatory time before self-admin	0.3	0.3	1.1	0.7	0.5	-0.0	-0.0	-0.0	1.1
Ambulatory time after self-admin	0.2	0.2	0.4	0.7	0.4	0.2	-0.2	0.4	0.4
Total heroin consumption	0.8	0.9	1.7	0.8	0.6	-1.1	1.1	0.2	1.3
Area under the delay curve	0.1	0.1	0.2	0.1	-0.1	0.5	-0.4	-0.3	0.2
Delay disc. indifference point, 0s delay	0.2	0.2	0.8	-0.1	-0.5	0.2	-0.1	-0.9	-0.0
Delay disc. indifference point, 16s delay	0.5	0.5	1.4	-0.3	-0.4	1.2	-1.1	-0.3	-0.3
Delay disc. indifference point, 2s delay	1.6	1.8	2.7	1.7	1.3	-1.2	1.2	1.0	1.5
Delay disc. indifference point, 24s delay	0.1	0.1	0.5	0.3	0.3	0.0	-0.1	-0.2	0.7
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	-0.1	-0.4	0.5	-0.4	-0.4	-0.0
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	-0.2	-0.4	-0.1	0.3	-0.3	-0.4
Delay discount exponential model param	0.1	0.1	0.2	-0.4	-0.1	-0.5	0.4	0.2	-0.4
Delay discount hyperbolic model param	0.1	0.1	0.2	-0.5	-0.2	-0.2	0.1	0.1	-0.4
Fecal boli incidents, locomotor time 1	0.0	0.1	0.2	-0.2	-0.1	-0.2	0.2	0.1	-0.4
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.4	0.3	0.2	-0.2	0.2	0.4
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.3	-0.8	-1.1	-0.2	0.2	-0.8	-0.5
Bouts of movement, locomotor time 1	1.0	1.1	1.9	-1.4	-1.2	0.5	-0.7	-0.8	-1.2
Total resting periods, locomotor time 1	1.0	1.1	2.2	-1.5	-1.3	0.6	-0.8	-0.7	-1.2
Rest time, locomotor task time 1	0.3	0.3	0.5	-0.6	-0.7	-0.5	0.5	-0.3	-0.5
Distance moved, locomotor task time 1	0.4	0.5	0.6	0.8	0.7	0.7	-0.6	0.3	0.8
Vertical activity count, locomotor time 1	0.3	0.4	0.6	0.6	0.4	0.8	-0.8	0.3	0.5
Time >=10cm from walls, locomotor time 2	0.5	0.6	0.8	0.6	0.5	-0.9	0.9	0.8	0.7
Bouts of movement, locomotor time 2	0.2	0.3	0.5	0.5	0.3	-0.7	0.5	0.6	0.3
Total resting periods, locomotor time 2	0.0	0.0	0.1	0.1	-0.2	-0.3	0.2	0.3	-0.1
Rest time, locomotor task time 2	0.9	1.0	1.4	-1.1	-1.0	1.0	-1.2	-0.8	-0.9
Distance moved, locomotor task time 2	0.1	0.1	0.4	0.6	0.4	-0.1	0.2	0.2	0.5
Vertical activity count, locomotor time 2	0.8	0.8	1.2	1.1	0.8	-0.9	1.0	0.7	0.9
Weight adjusted by age	0.1	0.1	0.4	0.1	-0.2	0.2	-0.2	-0.5	0.6
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	1.9	0.3	0.3	1.4	-1.4	-0.6	0.8
Locomotion in novel chamber	0.3	0.4	0.9	0.9	0.5	-0.3	0.2	0.1	0.9
Locomotion in novel chamber post-restriction	1.3	1.5	2.4	1.5	1.4	-0.9	0.9	1.5	1.0
Progressive ratio	0.0	0.0	0.0	0.2	0.0	-0.1	0.2	-0.1	-0.2
Food seeking constrained by brief footshock	0.1	0.2	0.5	0.4	0.6	0.2	-0.1	-0.2	0.7
Seeking ratio, punishment vs. effort	0.1	0.2	0.5	0.1	0.4	0.4	-0.3	-0.0	0.7
Run reversals in cocaine runway, females	0.8	0.8	2.0	-0.5	-0.6	1.3	-1.4	-0.2	-0.6
Run reversals in cocaine runway, males	1.0	1.0	2.0	1.1	1.1	-0.7	0.7	1.4	0.8
Latency to leave start box in cocaine runway	1.2	1.3	2.8	-0.8	-0.8	1.6	-1.7	-0.6	-0.9
Latency to leave start box in cocaine runway, F	3.1	3.4	7.9	-1.1	-1.2	2.8	-2.7	-1.0	-1.3
Latency to leave start box in cocaine runway, M	0.7	0.6	2.2	-0.1	0.0	-1.5	1.3	0.1	-0.0
Cd content in liver	4.0	4.4	8.3	-2.5	-2.5	1.2	-1.3	-2.9	-1.8
Co content in liver	0.9	1.0	4.1	-0.9	-0.8	0.3	-0.3	-2.0	0.8
Cu content in liver	0.6	0.7	1.3	0.4	0.6	-1.1	1.1	0.1	1.1
Fe content in liver	3.5	4.1	7.9	-2.8	-2.5	0.5	-0.5	-1.8	-2.6
K content in liver	2.5	2.5	6.6	0.7	0.5	-2.5	2.6	0.6	1.0
Mg content in liver	2.8	2.9	7.6	-0.9	-0.9	-2.7	2.8	-0.8	-0.2
Mn content in liver	4.1	4.6	12.0	0.6	0.9	-3.4	3.5	1.7	0.3
Na content in liver	0.6	0.6	1.2	0.7	0.4	-1.1	1.1	-0.2	0.9
Rb content in liver	1.2	1.5	2.4	-0.8	-1.3	-1.4	1.4	-1.5	-0.5
Se content in liver	2.3	2.8	5.2	-2.3	-1.9	0.8	-0.8	-2.1	-1.5
Sr content in liver	0.3	0.3	0.6	-0.8	-0.6	0.6	-0.6	-0.2	-0.1
Zn content in liver	0.2	0.3	0.7	-0.2	-0.2	-0.8	0.8	-0.2	0.3