Hub : Traits

body_g

Project: dissection

2611 significantly associated models · 435 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 120674658 122571615 3 1 1.8e-08 1.4e-07 3.3e-01 97 Fam169b
2 1 203698095 205092962 1 1 1.6e-07 7.5e-07 3.8e-02 83 Otub1
3 1 251447555 253100945 3 1 3.8e-08 2.8e-08 5.2e-02 88 Add3
4 1 253445764 260518987 41 7 4.1e-40 4.1e-41 NaN NaN Gpam Habp2 Eno4 Sfxn4 Tcf7l2 NA NA
5 2 43366934 44763574 1 1 1.4e-07 9.9e-08 1.0e-03 62 Il6st
6 2 117887529 120258488 8 1 3.7e-08 3.1e-08 1.0e+00 100 Qrfpr
7 2 123236866 125075599 4 1 4.6e-10 1.2e-06 3.0e-03 63 Jade1
8 2 226367830 227766193 1 1 2.1e-07 1.4e-08 2.2e-02 84 Eif4e
9 3 106069409 108252074 8 1 6.0e-08 1.3e-07 1.0e+00 100 Ehd4
10 3 114188900 117826996 27 1 3.3e-08 3.0e-08 1.0e+00 100 Ubox5
11 3 126160536 128707024 7 3 3.3e-12 2.2e-12 1.0e+00 100 Sptlc3 Ndufaf5 AABR07054000.1
12 3 129554891 132898674 17 9 9.6e-19 1.4e-17 1.0e+00 100 Kif16b Pcsk2 Dstn Kat14 Rbbp9 Sec23b Otor Smim26 NA
13 5 47710012 49968409 6 2 6.7e-09 2.6e-09 1.0e+00 100 Cfap206 RGD1359108
14 5 147778855 149174573 1 1 1.5e-07 8.0e-08 1.0e+00 100 Tcea3
15 6 96850756 98633235 4 1 1.5e-08 2.3e-08 2.0e-01 95 Pigh
16 6 100080023 100868818 1 1 2.3e-07 4.4e-07 1.0e+00 100 Galnt16
17 7 24880148 26365256 3 1 8.7e-08 5.1e-08 1.0e+00 100 Ikbip
18 7 26902995 30734621 20 6 3.0e-20 5.7e-25 NaN NaN Cdk17 Elk3 Tmcc3 Cradd Socs2 Mir331
19 7 81442141 85355253 4 1 5.4e-10 8.9e-12 2.7e-05 62 Med30
20 7 127692699 132411050 45 6 1.3e-09 2.7e-09 1.0e+00 100 Zfp641 Tuba1b Hdac7 Ddx23 Kansl2 NA
21 8 75290117 76689055 1 1 2.9e-07 7.5e-08 1.2e-63 -881 Myo5c
22 8 89750909 91141602 1 1 1.6e-07 7.0e-06 8.6e-01 100 Rasgrf1
23 8 95494368 98183778 7 2 5.5e-10 1.7e-08 1.6e-119 -1598 Atp1b3 Zbtb38
24 8 108584253 112100485 41 6 7.8e-10 9.9e-10 1.0e+00 100 Cspg5 Setd2 Pth1r Dclk3 Mlh1 Ccdc71
25 9 12682987 14081256 1 1 2.8e-07 2.2e-06 1.7e-02 75 Med20
26 10 81874092 84687108 20 1 2.7e-08 8.6e-08 3.6e-01 97 NA
27 10 87823507 89221041 1 1 2.3e-07 3.2e-06 2.2e-01 93 Prp2l1
28 10 92588108 96071622 16 5 1.8e-10 1.5e-10 NaN NaN Wipi1 Arsg Abca8a Map2k6 Abca9
29 10 105128372 107195627 3 1 1.0e-07 1.9e-07 9.3e-89 -1369 NA
30 11 2994207 4393389 1 1 1.5e-09 2.1e-06 8.7e-01 100 NA
31 12 27006 6860177 42 5 2.8e-22 7.6e-22 1.0e+00 100 Pcp2 Snapc2 Stard13 Brca2 B3glct
32 14 61859220 63251899 1 1 6.3e-09 3.8e-09 1.0e+00 100 Pacrgl
33 14 77172158 78568533 1 1 1.4e-07 2.9e-06 1.4e-01 90 Prr14l
34 18 25166673 27022191 10 5 1.5e-10 3.3e-10 1.0e+00 100 Reep5 Fam13b Apc Cdc23 Epb41l4a
35 20 3201 847737 3 3 2.6e-08 4.3e-08 0.0e+00 -16307 Clic2 Tmlhe NA
36 20 883910 4846491 56 7 4.6e-10 3.2e-09 1.0e+00 100 Abcf1 Mrps18b Atat1 RT1-N2 NA RT1-CE11 NA
37 20 5885475 8780288 23 5 1.3e-09 4.1e-09 1.0e+00 100 Slc26a8 Mapk14 RGD735065 Ccdc167 NA

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
dissection: UMAP 1 of all traits 10.5 244 132 140.4 -0.98 0.0e+00 Slc16a6 Amz2 Slc26a8 Mapk14 Kctd20 Stk38 Cdkn1a Cpne5 RGD735065 Pi16 Mtch1 Fgd2 Cmtr1 RT1-S3 RT1-N3 Gnl1 Abcf1 Mrps18b Atat1 Gtf2h4 Vars2 Ddx39b Gpank1 Zfp958l1 Fry Rxfp2 Hsph1 Wdr95 Tex26 Mcoln1 Pnpla6 Camsap3 Xab2 Pcp2 Stxbp2 Retn Trappc5 Evi5l Map2k7 Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Prkca Apoh Rgs9 Wipi1 Arsg Pacrgl Cdk17 Elk3 Rad21 Sptlc3 Tasp1 Lta4h Hal Esf1 Ndufaf5 Med30 Flrt3 Kif16b Snrpb2 Amdhd1 Pcsk2 Rpap1 Snrpf Ntn4 Dstn Rrbp1 Vezt Nr2c1 Mapkbp1 Kat14 Ndufa12 Dzank1 Polr3f Ehd4 Tmcc3 Plxnc1 Rbbp9 Sec23b Cradd Capn3 Dtd1 Socs2 Lrrc57 Pdzd8 Scp2d1 Rab11fip2 Fam204a Prlhr Pls1 Cacul1 Dennd10 Gk5 Prdx3 Tfdp2 Grk5 Atp1b3 Zbtb38 Add3 Med20 Jade1 Smndc1 Gpam Tectb Gucy2g Acsl5 Habp2 Nrap Nhlrc2 Adrb1 Tdrd1 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Hspa12a Eno4 Reep5 Fam13b Apc Slc26a6 Pfkfb4 Shisa5 Atrip Nme6 Camp Cdc25a Map4 Smarcc1 Cspg5 Elp6 Kif9 Setd2 Ccdc12 Pth1r Myl3 Lrrfip2 Trank1 Metap2 Ccdc38 Cdc23 Ngp AABR07056633.1 Cep112 Ganc Trps1 Nanos1 Pkd2l2 Vwa2 Prr3 AABR07044362.1 Dclre1a Tmie Nbeal2 Zfp133 Arhgef18 Pex11g Mgme1 Mcemp1 Lrrc8e Pnpla1 Otor RT1-S2 RT1-N2 AABR07035218.1 Insr Dhx16 Lrrc2 NA RT1-T24-1 RT1-S2 Zfp950 Dclk3 AABR07030647.1 Mlh1 Als2cl Mxi1 Mir331 Ces2c Sfxn4 Zdhhc6 Smim26 Prss50 Larp1b RT1-CE11 Vti1a RT1-T24-4 AABR07007032.1 PCOLCE2 Abca6 Katnal1 Prr14l NA NA Tcf7l2 Prkar1a Pet100 Cchcr1 AABR07054000.1 Ccdc186 Celsr3 Fgd6 Trpc1 Axin2 Casp7 Ddr1 Tcf19 Sptbn5 Ppp1r10 N4bp2l1 Tbc1d22b Tubb5 B3glct RT1-T18 NA Ism1 NA NA RT1-CE16 NA RT1-CE15 Zfp958 NA NA NA NA NA NA NA NA Ccdc167 NA NA NA NA NA
retroperitoneal_fat_g 15.8 85 64 68.1 1.00 0.0e+00 Slc16a6 Amz2 Prkca Apoh Rgs9 Wipi1 Sptlc3 Tasp1 Esf1 Ndufaf5 Flrt3 Kif16b Snrpb2 Pcsk2 Rpap1 Dstn Rrbp1 Mapkbp1 Kat14 Dzank1 Polr3f Ehd4 Rbbp9 Sec23b Dtd1 Lrrc57 Pdzd8 Scp2d1 Rab11fip2 Fam204a Prlhr Cacul1 Dennd10 Prdx3 Grk5 Add3 Smndc1 Gpam Tectb Gucy2g Acsl5 Habp2 Nrap Nhlrc2 Adrb1 Tdrd1 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Hspa12a Eno4 Cep112 Nanos1 Vwa2 Dclre1a Zfp133 Mgme1 Otor AABR07035218.1 Zfp950 AABR07030647.1 Mxi1 Ces2c Sfxn4 Zdhhc6 Mcrip1 Smim26 Vti1a AABR07007032.1 Tcf7l2 AABR07054000.1 Ccdc186 Axin2 Casp7 Sptbn5 NA Ism1 NA NA NA NA NA NA
dissection: UMAP 3 of all traits 10.7 60 32 34.0 -0.98 3.2e-206 RT1-N3 Abcf1 Atat1 Gtf2h4 Zfp958l1 Fry Rxfp2 Hsph1 Wdr95 Mcoln1 Pnpla6 Camsap3 Xab2 Pcp2 Stxbp2 Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Elk3 Lta4h Vezt Nr2c1 Ndufa12 Tmcc3 Cep83 Plxnc1 Socs2 Il6st Metap2 Arhgef18 Pex11g Mcemp1 Lrrc8e Insr Dhx16 NA RT1-T24-1 Mir331 Katnal1 Pet100 Cchcr1 Fgd6 Ddr1 N4bp2l1 B3glct RT1-T18 NA NA Zfp958 NA NA NA
kidney_right_g 9.1 69 42 44.7 0.99 2.8e-208 Zfp958l1 Fry Rxfp2 Hsph1 Wdr95 Mcoln1 Pnpla6 Camsap3 Xab2 Pcp2 Stxbp2 Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 Pds5b N4bp2l2 Brca2 Rab11fip2 Fam204a Prlhr Cacul1 Dennd10 Prdx3 Grk5 Gpam Gucy2g Acsl5 Habp2 Nrap Nhlrc2 Adrb1 Tdrd1 Nanos1 Vwa2 Dclre1a Arhgef18 Pex11g Mcemp1 Lrrc8e AABR07035218.1 Insr Zfp950 Ces2c Sfxn4 Zdhhc6 Vti1a AABR07007032.1 Katnal1 Tcf7l2 Pet100 Ccdc186 Trpc1 Casp7 N4bp2l1 B3glct NA Zfp958 NA NA NA NA NA NA NA NA
dissection: PC 3 of all traits 9.4 9 2 2.1 0.49 3.2e-02 Evi5l Tmcc3 Plxnc1 Socs2 Rab11fip2 Prlhr Cacul1 NA NA
dissection: PC 2 of all traits 10.9 18 10 10.6 -0.82 6.2e-14 Zfp958l1 Brca2 Kif16b Snrpb2 Socs2 Pdzd8 Rab11fip2 Prlhr Cacul1 Dennd10 Grk5 Med20 Nanos1 Zfp950 Ces2c Sfxn4 NA NA
heart_g 13.4 1 0 0.0 0.00 1.0e+00 Cacul1
os_mean 14.9 1 0 0.0 0.00 1.0e+00 Tmem106c
EDL weight in grams 6.1 111 41 43.6 0.97 2.5e-321 Zfp958l1 Fry Rxfp2 Mcoln1 Pnpla6 Camsap3 Xab2 Pcp2 Stxbp2 Trappc5 Evi5l Map2k7 Snapc2 Timm44 Elavl1 Cers4 Stard13 Pds5b N4bp2l2 Brca2 Lasp1 Rad21 Cacnb1 Rpl19 Stac2 Med30 Fbxl20 Cdk12 Amigo2 Zpbp2 Orc3 Rars2 Slc35a1 RGD1359108 Msl1 Asb8 Igfbp4 Srcin1 Pcgf2 Dcun1d1 Pip4k2b RGD1565989 Jade1 Acad9 Qrfpr Anxa5 Bbs7 Trpc3 Otub1 Tuba1c Senp1 Pced1b Ext1 Arhgef18 Pex11g Mcemp1 NA Lrrc8e Insr Ormdl3 Zfp641 Olr1106 Cisd3 Larp1b Stard3 Pet100 Atp11b Spats2 Eif4e Psmb3 Prph Cers5 Ccnt1 Slc48a1 Tmem106c Mllt6 Rpap3 Tuba1b Cacnb3 Vdr Adcy6 Fkbp11 Axin2 Tmbim6 Hdac7 Endou Tex49 Pfkm Col2a1 Ccdc65 N4bp2l1 Rnd1 Rapgef3 Ddx23 Kansl2 Kmt2d NA NA Zfp958 NA Olr1107 NA Tcap NA NA NA Prkag1 Olr1877 Olr1108 Fkbp11 NA
Tibia length in mm 7.9 122 24 25.5 0.98 0.0e+00 Mcoln1 Stxbp2 Trappc5 Evi5l Snapc2 Stard13 Pds5b N4bp2l2 Brca2 Cdk17 Elk3 Tasp1 Lta4h Hal Esf1 Ndufaf5 Flrt3 Kif16b Snrpb2 Amdhd1 Snrpf Ntn4 Vezt Nr2c1 Ndufa12 Tmcc3 Cep83 Plxnc1 Cradd Socs2 Asb8 Slc26a6 Pfkfb4 Shisa5 Atrip Ccdc51 Nme6 Camp Cdc25a Map4 Smarcc1 Cspg5 Elp6 Scap Ptpn23 Klhl18 Kif9 Setd2 Ccdc12 Pth1r Myl3 Lrrfip2 Trank1 Tuba1c Metap2 Ccdc38 Senp1 Ngp AABR07056633.1 Tmie Nbeal2 Pex11g Lrrc8e Otor Insr Lrrc2 AC107280.1 Nckipsd Zfp641 Olr1106 Dclk3 Mlh1 Als2cl Mir331 Mcrip1 Rtp3 Prss50 Epm2aip1 Tma7 Ccdc71 Pet100 AABR07054000.1 Spats2 Prph Ccnt1 Slc48a1 Tmem106c Rpap3 Tuba1b Dnajc22 Dhh Celsr3 Cacnb3 Rhebl1 Fgd6 Adcy6 Fkbp11 Hdac7 Tex49 Kcnh3 Pfkm Col2a1 Ccdc65 Rnd1 Rapgef3 Ddx23 Kansl2 Kmt2d NA NA NA NA Ism1 Olr1107 NA NA NA NA Prkag1 Olr1877 Olr1108 Fkbp11
sol weight in grams 7.0 9 0 0.0 0.99 1.3e-18 Gpam Habp2 Fhip2a Trub1 Atrnl1 Eno4 AABR07007032.1 NA NA
TA weight in grams 7.5 56 40 42.6 0.98 3.8e-179 Zfp958l1 Fry Rxfp2 Mcoln1 Pnpla6 Camsap3 Xab2 Pcp2 Stxbp2 Retn Trappc5 Evi5l Map2k7 Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Cnr1 Orc3 Rars2 Mpp5 Slc35a1 Cfap206 Atp6v1d RGD1359108 Pigh Dcun1d1 RGD1565989 Jade1 Acad9 Qrfpr Anxa5 Bbs7 Trpc3 Otub1 Ext1 Arhgef18 Pex11g Mcemp1 Lrrc8e Insr Larp1b Pet100 Atp11b Eif4e Arg2 N4bp2l1 Zfp958 NA NA NA
Total sessions with >9 infusions 19.8 1 0 0.0 0.00 1.0e+00 Casp7
Total cortical area 14.1 3 2 2.1 1.00 6.2e-10 Tasp1 Esf1 Ndufaf5
tb_th_sd 15.8 2 0 0.0 0.00 1.0e+00 Prlhr Cacul1
length 10.6 84 1 1.1 1.00 0.0e+00 RT1-S3 RT1-N3 Gnl1 Abcf1 Mrps18b Atat1 Flot1 Gtf2h4 Vars2 Gpank1 Apom Amigo2 Asb8 Il6st Tuba1c Senp1 Pced1b Prr3 AABR07044362.1 RT1-S2 RT1-N2 Dhx16 RT1-CE1 NA Zfp641 RT1-T24-1 RT1-S2 Mdc1 Olr1106 RT1-CE11 RT1-T24-4 RT1-CE2 NA AABR07044375.1 Cchcr1 Spats2 Prph Cers5 Ccnt1 Slc48a1 Tmem106c Rpap3 Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Vdr Adcy6 Fkbp11 Tmbim6 Hdac7 Endou Ddr1 Tex49 Kcnh3 Pfkm Tcf19 Col2a1 Ccdc65 Ppp1r10 Rnd1 Rapgef3 Ddx23 Kansl2 Tubb5 Kmt2d NA RT1-T18 NA NA NA NA RT1-CE16 RT1-CE15 NA NA NA NA NA Prkag1 Olr1877 Olr1108 Fkbp11
tautz: manual_spc8 15.8 7 4 4.3 1.00 2.4e-48 Reep5 Srp19 Brd8 Fam13b Apc Cdc23 Pkd2l2
tautz: manual_mpc10 15.4 4 0 0.0 1.00 3.4e-07 RGD1565989 Qrfpr Trpc3 Larp1b
tautz: manual_spc17 13.9 1 0 0.0 0.00 1.0e+00 Abca6
tautz: manual_spc20 14.5 5 0 0.0 -1.00 2.3e-10 RGD1565989 Jade1 Qrfpr Trpc3 Larp1b
tautz: manual_mpc13 14.5 3 0 0.0 -1.00 1.2e-14 Reep5 Apc Cdc23
punishment 22.0 1 1 1.1 1.00 2.4e-06 RGD1359108

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 62 2.92 4.6
Adipose alternative TSS 22 1.36 4.0
Adipose gene expression 118 1.42 3.9
Adipose isoform ratio 58 2.05 4.3
Adipose intron excision ratio 43 1.47 3.8
Adipose mRNA stability 59 1.71 4.1
BLA alternative polyA 12 1.00 4.3
BLA alternative TSS 10 1.19 4.1
BLA gene expression 115 1.90 4.3
BLA isoform ratio 28 1.59 4.4
BLA intron excision ratio 68 2.28 4.5
BLA mRNA stability 49 2.42 4.5
Brain alternative polyA 28 1.40 4.2
Brain alternative TSS 30 1.75 4.4
Brain gene expression 152 1.68 4.1
Brain isoform ratio 60 1.90 4.2
Brain intron excision ratio 98 1.81 4.3
Brain mRNA stability 73 1.67 4.0
Eye alternative polyA 0 0.00 4.2
Eye alternative TSS 6 2.50 4.1
Eye gene expression 18 1.60 4.2
Eye isoform ratio 5 1.41 4.3
Eye intron excision ratio 13 2.12 4.8
Eye mRNA stability 3 1.29 4.3
IL alternative polyA 10 1.64 4.8
IL alternative TSS 3 1.04 4.4
IL gene expression 61 1.67 4.3
IL isoform ratio 18 2.28 4.7
IL intron excision ratio 12 1.24 4.4
IL mRNA stability 23 2.07 4.3
LHb alternative polyA 7 1.22 4.7
LHb alternative TSS 2 0.57 3.8
LHb gene expression 58 1.81 4.3
LHb isoform ratio 5 0.66 4.4
LHb intron excision ratio 9 0.87 4.5
LHb mRNA stability 24 2.32 4.5
Liver alternative polyA 30 2.00 4.3
Liver alternative TSS 20 1.32 4.0
Liver gene expression 102 1.42 4.0
Liver isoform ratio 40 1.67 4.3
Liver intron excision ratio 68 1.56 3.9
Liver mRNA stability 50 2.04 4.2
NAcc alternative polyA 11 2.11 5.2
NAcc alternative TSS 6 1.75 4.3
NAcc gene expression 54 1.64 4.2
NAcc isoform ratio 11 1.48 4.2
NAcc intron excision ratio 17 1.78 4.6
NAcc mRNA stability 19 1.76 4.3
NAcc2 alternative polyA 16 1.45 4.2
NAcc2 alternative TSS 14 1.91 4.3
NAcc2 gene expression 103 1.93 4.3
NAcc2 isoform ratio 25 1.62 4.4
NAcc2 intron excision ratio 47 1.78 4.3
NAcc2 mRNA stability 29 1.62 4.3
OFC alternative polyA 10 1.71 4.9
OFC alternative TSS 6 1.88 4.6
OFC gene expression 68 1.84 4.4
OFC isoform ratio 8 0.98 4.5
OFC intron excision ratio 18 1.79 4.8
OFC mRNA stability 22 2.04 4.7
PL alternative polyA 8 1.34 4.5
PL alternative TSS 2 0.65 4.2
PL gene expression 65 1.75 4.2
PL isoform ratio 15 1.72 4.3
PL intron excision ratio 25 2.40 4.7
PL mRNA stability 22 1.91 4.5
PL2 alternative polyA 20 1.59 4.5
PL2 alternative TSS 30 3.19 4.7
PL2 gene expression 118 1.85 4.3
PL2 isoform ratio 30 1.63 4.4
PL2 intron excision ratio 72 2.29 4.6
PL2 mRNA stability 48 1.97 4.4

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.