Hub : Traits

Body weight

Tags: Physiology · Weight

Project: dissection

2481 significantly associated models · 436 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 120674658 122571615 3 1 1.8e-08 1.4e-07 3.3e-01 97 Fam169b
2 1 169640200 171030889 1 1 2.6e-07 1.1e-06 1.0e+00 100 RGD1311703
3 1 203698095 205092962 1 1 1.6e-07 7.5e-07 3.8e-02 83 Otub1
4 1 251447555 260518987 43 6 4.1e-40 4.1e-41 NaN NaN Gpam Acsl5 AABR07007068.1 Sfxn4 AABR07007032.1 Tcf7l2
5 2 43366934 44763574 1 1 1.4e-07 9.9e-08 1.0e-03 62 Il6st
6 2 117887529 120258488 8 1 3.7e-08 3.1e-08 1.0e+00 100 Qrfpr
7 2 123236866 125075599 4 1 4.6e-10 1.2e-06 3.0e-03 63 Jade1
8 2 127918544 129316922 1 1 2.6e-07 1.2e-07 1.2e-01 92 Pcdh10
9 2 226367830 228342320 2 1 2.1e-07 1.4e-08 2.2e-02 84 Eif4e
10 3 106069409 108252074 7 1 6.0e-08 1.3e-07 1.0e+00 100 Ehd4
11 3 114188900 117826996 25 1 3.3e-08 3.0e-08 1.0e+00 100 Ubox5
12 3 126160536 128707024 7 3 5.5e-12 2.2e-12 1.0e+00 100 Sptlc3 Tasp1 AABR07054000.1
13 3 129554891 132693612 16 6 9.6e-19 1.4e-17 1.0e+00 100 Kif16b Pcsk2 Rbbp9 Sec23b Dtd1 Otor
14 5 47710012 49968409 6 3 6.2e-09 2.6e-09 1.0e+00 100 Slc35a1 Cfap206 RGD1359108
15 5 147735242 149174573 2 1 8.0e-08 8.0e-08 1.0e+00 100 Asap3
16 6 96850756 98793722 5 1 1.5e-08 2.3e-08 2.0e-01 95 Pigh
17 7 16845355 16970279 1 1 6.1e-12 NaN NA NA NA
18 7 24880148 26365256 2 1 1.5e-07 5.1e-08 1.0e+00 100 Tmpo
19 7 26902995 30734621 20 5 1.1e-24 5.7e-25 NaN NaN Vezt Tmcc3 Cep83 Cradd Ccdc38
20 7 81442141 85355253 4 1 5.4e-10 8.9e-12 2.7e-05 62 Med30
21 7 127692699 132056754 42 12 1.3e-09 2.7e-09 1.0e+00 100 Amigo2 Slc48a1 Rpap3 Fkbp11 Tmbim6 Hdac7 Rapgef3 Kansl2 Atf1 NA Prkag1 Fkbp11
22 8 89750909 91141602 1 1 1.6e-07 7.0e-06 8.6e-01 100 Rasgrf1
23 8 95494368 98183778 8 2 5.5e-10 1.7e-08 1.6e-119 -1598 Atp1b3 Zbtb38
24 8 108584253 112100485 41 6 7.8e-10 9.9e-10 1.0e+00 100 Prkar2a Nme6 Setd2 Pth1r Nbeal2 Dclk3
25 10 81874092 84687108 21 5 5.7e-09 8.6e-08 1.0e+00 100 Rpl19 Cdk12 Igfbp4 Ppp1r1b Arl5c
26 10 87823507 89221041 1 1 2.3e-07 3.2e-06 2.2e-01 93 Prp2l1
27 10 92588108 96071622 16 7 1.8e-10 1.5e-10 1.0e+00 100 Amz2 Prkca Wipi1 Arsg Map2k6 Cep112 Abca9
28 10 105128372 107195627 4 1 1.5e-13 1.9e-07 6.1e-24 -275 Ccdc57
29 11 2994207 4393389 1 1 1.5e-09 2.1e-06 8.7e-01 100 NA
30 12 27006 7325669 43 5 2.8e-22 7.6e-22 NaN NaN Fry Snapc2 Arhgef18 Insr Pet100
31 14 61859220 63251899 1 1 2.6e-08 3.8e-09 2.9e-02 86 Pacrgl
32 14 77172158 78568533 1 1 1.4e-07 2.9e-06 1.4e-01 90 Prr14l
33 18 25166673 27022191 12 4 4.2e-11 3.3e-10 1.0e+00 100 Reep5 Fam13b Cdc23 Epb41l4a
34 20 3201 4846491 59 16 4.6e-10 3.2e-09 1.0e+00 100 Prrt1 Clic2 Tmlhe AC112568.1 Abcf1 Mrps18b Atat1 Ly6g6e NA AABR07044388.2 RT1-CE11 Cchcr1 Ddr1 Tubb5 RT1-CE14 NA
35 20 5885475 8780288 23 6 1.3e-09 4.1e-09 1.0e+00 100 Slc26a8 Mapk14 RGD735065 Rab44 Rnf8 Ccdc167

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI with tail 10.2 132 78 72.9 1.00 0.0e+00 Slc16a6 Amz2 Prkca Apoh Rgs9 Wipi1 Arsg Abca8a Rad21 Map2k6 Tasp1 Ndufaf5 Med30 Flrt3 Kif16b Snrpb2 Pcsk2 Rpap1 Dstn Rrbp1 Mapkbp1 Kat14 Dzank1 Polr3f Ehd4 Rbbp9 Sec23b Capn3 Dtd1 Pdzd8 Rab11fip2 Fam204a Prlhr Pls1 Cacul1 Dennd10 Gk5 Prdx3 Tfdp2 Grk5 Atp1b3 Zbtb38 Dcun1d1 RGD1565989 Jade1 Qrfpr Anxa5 Gpam Ccna2 Tectb Gucy2g Bbs7 Trpc3 Acsl5 Habp2 Nrap Nhlrc2 Adrb1 Tdrd1 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Hspa12a Eno4 Nme5 Reep5 Srp19 Gfra3 Brd8 Fam13b Apc Otub1 Senp1 Cdc23 Kif20a Cep112 Ganc Ext1 Trps1 Nanos1 Pkd2l2 Epb41l4a Dclre1a Zfp133 Mgme1 Lrrc8e Otor Zfp641 Zfp950 Olr1106 AABR07030647.1 Ces2c Sfxn4 Zdhhc6 Smim26 RGD1359508 Larp1b Vti1a AABR07007032.1 PCOLCE2 Abca6 Bbip1 Ccdc57 Prr14l Tcf7l2 Prkar1a AABR07054000.1 Ccdc186 Atp11b Tmem106c Rpap3 RGD1311703 Trpc1 Axin2 Hdac7 Casp7 Pfkm Sptbn5 Abca9 Ddx23 Atf1 NA NA NA NA NA NA NA NA NA
BMI without tail 17.5 27 16 15.0 0.96 5.9e-55 Kif16b Snrpb2 Pcsk2 Dstn Rrbp1 Vezt Pdzd8 Rab11fip2 Prlhr Pls1 Cacul1 Dennd10 Prdx3 Grk5 Reep5 Metap2 Trps1 Nanos1 Otor Zfp950 Ces2c Sfxn4 RGD1311703 Trpc1 NA NA NA
Epididymis fat weight 16.5 69 41 38.3 0.99 3.2e-246 Slc16a6 Amz2 Prkca Apoh Rgs9 Wipi1 Arsg Sptlc3 Tasp1 Ndufaf5 Flrt3 Kif16b Snrpb2 Pcsk2 Dstn Rrbp1 Rbbp9 Sec23b Pdzd8 Rab11fip2 Fam204a Prlhr Cacul1 Dennd10 Prdx3 Grk5 Add3 Smndc1 Gpam Tectb Gucy2g Acsl5 Habp2 Nrap Nhlrc2 Adrb1 Tdrd1 Afap1l2 Fhip2a Trub1 Atrnl1 Hspa12a Eno4 Cep112 Nanos1 Dclre1a Zfp133 Otor Zfp950 AABR07030647.1 Mxi1 Ces2c Sfxn4 Zdhhc6 AABR07007032.1 Bbip1 Tcf7l2 Prkar1a AABR07054000.1 Ccdc186 Fgd6 Axin2 Casp7 Ism1 NA NA NA NA NA
Heart weight 13.5 1 0 0.0 0.00 1.0e+00 Cacul1
Left kidney weight 10.2 63 38 35.5 0.98 2.1e-173 Zfp958l1 Fry Rxfp2 Hsph1 Wdr95 Alox5ap Mcoln1 Camsap3 Xab2 Pcp2 Stxbp2 Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Rab11fip2 Prlhr Cacul1 Dennd10 Prdx3 Tfdp2 Grk5 Tcea3 Gpam Gucy2g Acsl5 Nanos1 Arhgef18 Pex11g Mcemp1 Lrrc8e Insr Zfp950 Ces2c Sfxn4 Zdhhc6 Vti1a Katnal1 Tcf7l2 Asap3 Pet100 RGD1311703 Casp7 N4bp2l1 B3glct NA NA Zfp958 NA NA NA NA NA NA NA NA
Right kidney weight 9.4 68 41 38.3 0.98 3.2e-174 Zfp958l1 Fry Rxfp2 Hsph1 Wdr95 Alox5ap Slc7a1 Mcoln1 Camsap3 Xab2 Pcp2 Stxbp2 Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 Pds5b N4bp2l2 Brca2 Rab11fip2 Prlhr Cacul1 Dennd10 Prdx3 Grk5 Gpam Gucy2g Acsl5 Habp2 Nrap Nhlrc2 Adrb1 Tdrd1 Atrnl1 Nanos1 Dclre1a Arhgef18 Mcemp1 Lrrc8e AABR07035218.1 Insr Zfp950 Ces2c Sfxn4 Zdhhc6 Vti1a AABR07007032.1 Katnal1 Tcf7l2 Pet100 RGD1311703 Trpc1 Casp7 N4bp2l1 B3glct NA NA Zfp958 NA NA NA NA NA NA NA
Tail length 8.2 117 48 44.9 0.98 0.0e+00 RT1-M3-1 RT1-S3 RT1-N3 Abcf1 Atat1 Gtf2h4 Vars2 Zfp958l1 Slc7a1 Mcoln1 Camsap3 Xab2 Pcp2 Stxbp2 Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Cdk17 Elk3 Lta4h Hal Amdhd1 Snrpf Ntn4 Vezt Nr2c1 Ndufa12 Tmcc3 Cep83 Plxnc1 Apaf1 Cradd Tmpo Socs2 Zc3h8 Prkar2a Slc26a6 Pfkfb4 Shisa5 Atrip Ccdc51 Nme6 Camp Cdc25a Map4 Smarcc1 Cspg5 Elp6 Scap Ptpn23 Klhl18 Kif9 Setd2 Ccdc12 Pth1r Myl3 Lrrfip2 Trank1 Metap2 Ccdc38 Trex1 Ngp AABR07056633.1 AABR07044362.1 Zc3h6 Tmie Nbeal2 Arhgef18 Pex11g Mcemp1 Lrrc8e RT1-N2 Insr Dhx16 Lrrc2 AC107280.1 NA Nckipsd RT1-T24-1 Dclk3 Mlh1 Als2cl Mir331 Mcrip1 Rtp3 Prss50 RT1-M6-2 RT1-T24-4 Epm2aip1 Tma7 Pet100 AABR07044375.1 Cchcr1 AABR07044308.2 Celsr3 Fgd6 Ddr1 Tcf19 N4bp2l1 RT1-T18 NA NA NA NA RT1-CE15 Zfp958 NA NA NA
Length with tail 10.0 168 110 102.8 0.99 0.0e+00 Slc26a8 Tmlhe RT1-M3-1 RT1-S3 RT1-N3 Gnl1 Abcf1 Mrps18b Atat1 Gtf2h4 Vars2 Zfp958l1 Fry Rxfp2 Hsph1 Wdr95 Alox5ap Slc7a1 Mcoln1 Pnpla6 Camsap3 Xab2 Pcp2 Stxbp2 Retn Trappc5 Evi5l Map2k7 Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Lasp1 Cdk17 Elk3 Lta4h Hal Cacnb1 Rpl19 Kif16b Amdhd1 Snrpf Ntn4 Cdk12 Vezt Snrpb Nr2c1 Nop56 Ndufa12 Ebf4 Tmcc3 Cep83 Plxnc1 Apaf1 Cradd Tmpo Socs2 Srcin1 Il6st Synm Prkar2a Slc26a6 Pfkfb4 Shisa5 Atrip Ccdc51 Nme6 Camp Cdc25a Map4 Smarcc1 Cspg5 Elp6 Scap Ptpn23 Klhl18 Kif9 Setd2 Ccdc12 Pth1r Myl3 Lrrfip2 Trank1 Cpxm1 Pced1a Ptpra Mrps26 Ubox5 Metap2 Ccdc38 Trex1 Fam169b Ngp AABR07056633.1 Prr3 AABR07044362.1 Tmie Nbeal2 Arhgef18 Pex11g Mcemp1 NA Lrrc8e Otor RT1-S2 RT1-N2 Insr Dhx16 Lrrc2 AC107280.1 NA Nckipsd Impdh2 RT1-T24-1 RT1-S2 Dclk3 AABR07044388.2 Mlh1 Als2cl Mir331 Sfxn4 Arl5c Cisd3 Rtp3 Prss50 RT1-CE11 RT1-M6-2 Stard3 RT1-T24-4 Epm2aip1 Tma7 Katnal1 NA Pet100 AABR07044375.1 Cchcr1 Mllt6 Celsr3 Fgd6 Ddr1 Tcf19 Ppp1r10 N4bp2l1 Tubb5 B3glct RT1-T18 NA NA NA NA RT1-CE16 RT1-CE15 Zfp958 NA RT1-CE14 NA NA Tcap NA NA NA NA NA
Length without tail 11.5 81 33 30.8 0.96 1.0e-185 Zfp958l1 Fry Rxfp2 Hsph1 Wdr95 Alox5ap Mcoln1 Camsap3 Xab2 Pcp2 Stxbp2 Retn Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Elk3 Lta4h Amdhd1 Snrpf Ntn4 Vezt Ndufa12 Plxnc1 Cradd Socs2 Cacul1 Asb8 Il6st Map4 Metap2 Senp1 Trex1 Pced1b Arhgef18 Mcemp1 Lrrc8e AABR07035218.1 Insr Zfp641 Olr1106 Dclk3 Mir331 Katnal1 Pet100 Slc48a1 Tmem106c Rpap3 Tuba1b Cacnb3 Vdr Fgd6 Fkbp11 Hdac7 Pfkm Ccdc65 N4bp2l1 Rnd1 Rapgef3 Ddx23 Kansl2 B3glct Kmt2d NA NA NA Zfp958 NA NA NA NA Prkag1 Olr1877 Fkbp11
Liver weight, left 23.6 1 1 0.9 0.00 1.0e+00 NA
Liver weight, right 13.8 14 4 3.7 0.99 6.7e-28 Rxfp2 Rab11fip2 Prlhr Cacul1 Gpam Tectb Habp2 Nhlrc2 Nanos1 Zfp950 Sfxn4 Zdhhc6 Bbip1 NA
Parametrial fat weight 16.2 49 32 29.9 0.98 1.2e-186 Kif16b Snrpb2 Pcsk2 Dstn Rrbp1 Kat14 Dzank1 Polr3f Rbbp9 Sec23b Dtd1 Pdzd8 Rab11fip2 Fam204a Prlhr Cacul1 Dennd10 Prdx3 Grk5 Gpam Tectb Acsl5 Habp2 Nrap Nhlrc2 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Nanos1 Dclre1a Zfp133 Mgme1 Otor Zfp950 Ces2c Sfxn4 Zdhhc6 Smim26 AABR07007032.1 Tcf7l2 RGD1311703 Casp7 NA NA NA NA NA
Retroperitoneal fat weight 16.3 82 62 57.9 1.00 0.0e+00 Slc16a6 Amz2 Prkca Apoh Rgs9 Wipi1 Sptlc3 Tasp1 Esf1 Ndufaf5 Flrt3 Kif16b Snrpb2 Pcsk2 Dstn Rrbp1 Mapkbp1 Kat14 Dzank1 Polr3f Ehd4 Rbbp9 Sec23b Dtd1 Lrrc57 Pdzd8 Rab11fip2 Fam204a Prlhr Cacul1 Dennd10 Prdx3 Grk5 Add3 Smndc1 Gpam Tectb Gucy2g Acsl5 Habp2 Nrap Nhlrc2 Adrb1 Tdrd1 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Hspa12a Eno4 Cep112 Nanos1 Dclre1a Zfp133 Mgme1 Otor AABR07035218.1 Zfp950 AABR07030647.1 Mxi1 Ces2c Sfxn4 Zdhhc6 Mcrip1 Smim26 Vti1a AABR07007032.1 Bbip1 Tcf7l2 AABR07054000.1 Ccdc186 Axin2 Casp7 Sptbn5 NA Ism1 NA NA NA NA NA
Intraocular pressure 21.2 2 1 0.9 0.00 1.0e+00 Hdac7 NA
Extensor digitorum longus weight 6.2 111 47 43.9 0.96 2.7e-267 Zfp958l1 Fry Rxfp2 Mcoln1 Camsap3 Xab2 Pcp2 Stxbp2 Trappc5 Evi5l Map2k7 Snapc2 Timm44 Elavl1 Cers4 Stard13 Pds5b N4bp2l2 Brca2 Lasp1 Rad21 Cacnb1 Rpl19 Stac2 Med30 Fbxl20 Cdk12 Amigo2 Zpbp2 Orc3 Rars2 Slc35a1 Cfap206 Thra RGD1359108 Msl1 Asb8 Igfbp4 Srcin1 Pcgf2 Dcun1d1 RGD1565989 Jade1 Qrfpr Anxa5 Ccna2 Bbs7 Rap1gds1 Trpc3 Otub1 Tuba1c Senp1 Pced1b Arhgef18 Mcemp1 Ppp1r1b NA Lrrc8e Insr Ormdl3 Zfp641 Olr1106 Arl5c Cisd3 Larp1b Stard3 Pet100 Atp11b Eif4e Prph Ccnt1 Slc48a1 Tmem106c Mllt6 Rpap3 Tuba1b Cacnb3 Rhebl1 Vdr Adcy6 Fkbp11 Axin2 Tmbim6 Hdac7 Endou Tex49 Pfkm Ccdc65 N4bp2l1 Rnd1 Rapgef3 Ddx23 Kansl2 Atf1 Kmt2d NA NA NA Zfp958 NA Olr1107 NA Tcap NA NA NA Prkag1 Olr1877 Olr1108 Fkbp11 NA
Soleus weight 7.9 10 1 0.9 0.98 1.0e-12 Gpam Habp2 Fhip2a Trub1 Atrnl1 Eno4 AABR07007032.1 Casp7 NA NA
Tibialis anterior weight 7.8 59 41 38.3 0.94 3.4e-127 Zfp958l1 Fry Rxfp2 Mcoln1 Pnpla6 Camsap3 Xab2 Pcp2 Stxbp2 Retn Trappc5 Evi5l Map2k7 Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Cnr1 Orc3 Rars2 Mpp5 Slc35a1 Cfap206 Atp6v1d RGD1359108 Pigh Dcun1d1 RGD1565989 Jade1 Qrfpr Anxa5 Ccna2 Bbs7 Rap1gds1 Trpc3 Otub1 Arhgef18 Pex11g Mcemp1 Lrrc8e Insr Larp1b Pet100 Atp11b Eif4e Arg2 N4bp2l1 Zfyve26 Atf1 NA Zfp958 NA NA NA
Tibia length 7.9 117 28 26.2 0.98 0.0e+00 Mcoln1 Stxbp2 Trappc5 Evi5l Snapc2 Pds5b N4bp2l2 Brca2 Cdk17 Elk3 Tasp1 Lta4h Hal Esf1 Ndufaf5 Flrt3 Kif16b Amdhd1 Snrpf Ntn4 Vezt Nr2c1 Ndufa12 Tmcc3 Cep83 Plxnc1 Cradd Socs2 Asb8 Prkar2a Slc26a6 Pfkfb4 Shisa5 Atrip Ccdc51 Nme6 Camp Cdc25a Map4 Smarcc1 Cspg5 Elp6 Scap Ptpn23 Klhl18 Kif9 Setd2 Ccdc12 Pth1r Myl3 Lrrfip2 Trank1 Tuba1c Metap2 Ccdc38 Senp1 Trex1 Ngp AABR07056633.1 Tmie Nbeal2 Otor Insr AC107280.1 Nckipsd Zfp641 Olr1106 Dclk3 Mlh1 Als2cl Mir331 Mcrip1 Rtp3 Prss50 Epm2aip1 Tma7 Ccdc57 Pet100 AABR07054000.1 Spats2 Prph Ccnt1 Slc48a1 Tmem106c Rpap3 Tuba1b Dnajc22 Dhh Celsr3 Cacnb3 Rhebl1 Fgd6 Adcy6 Fkbp11 Hdac7 Tex49 Pfkm Ccdc65 Rnd1 Rapgef3 Ddx23 Kansl2 Kmt2d NA NA NA Ism1 NA Olr1107 NA NA NA NA Prkag1 Olr1877 Olr1108 Fkbp11
Number of licking bursts 242.4 1 1 0.9 0.00 1.0e+00 NA
Food consumed during 24 hour testing period 17.5 1 0 0.0 0.00 1.0e+00 NA
Times rat made contact with spout 121.6 1 1 0.9 0.00 1.0e+00 NA
Mean time between licks in bursts 90.5 1 1 0.9 0.00 1.0e+00 NA
Mean num. licks in bursts 258.2 1 1 0.9 0.00 1.0e+00 NA
Std. dev. time between licks in bursts 291.0 1 1 0.9 0.00 1.0e+00 NA
Indifference point 0 sec 21.3 1 1 0.9 0.00 1.0e+00 NA
Indifference point AUC 66.7 1 1 0.9 0.00 1.0e+00 NA
Delay discounting total patch changes 0 sec 20.1 1 1 0.9 0.00 1.0e+00 NA
Delay discounting total patch changes 12 sec 156.9 1 1 0.9 0.00 1.0e+00 NA
Delay discounting total patch changes 18 sec 277.7 1 1 0.9 0.00 1.0e+00 NA
Delay discounting total patch changes 24 sec 43.7 1 1 0.9 0.00 1.0e+00 NA
Delay discounting total patch changes 6 sec 145.0 1 1 0.9 0.00 1.0e+00 NA
Delay discounting water rate 0 sec 11.8 1 0 0.0 0.00 1.0e+00 NA
Delay discounting water rate 12 sec 44.2 1 1 0.9 0.00 1.0e+00 NA
Delay discounting water rate 24 sec 100.9 1 1 0.9 0.00 1.0e+00 NA
Delay discounting water rate 6 sec 70.2 1 1 0.9 0.00 1.0e+00 NA
Locomotor testing distance 14.0 1 0 0.0 0.00 1.0e+00 NA
Locomotor testing rearing 23.9 1 1 0.9 0.00 1.0e+00 NA
Light reinforcement 1 84.1 1 1 0.9 0.00 1.0e+00 NA
Reaction time num false alarms 90.1 1 1 0.9 0.00 1.0e+00 NA
Reaction time num false alarms AUC 128.2 1 1 0.9 0.00 1.0e+00 NA
Reaction time mean 62.5 1 1 0.9 0.00 1.0e+00 NA
Reaction time mean AUC 89.1 1 1 0.9 0.00 1.0e+00 NA
Median of all reaction times 80.2 1 1 0.9 0.00 1.0e+00 NA
Reaction time false alarm rate 104.2 1 1 0.9 0.00 1.0e+00 NA
Reaction time premature initiation rate 47.3 1 1 0.9 0.00 1.0e+00 NA
Reaction time premature initiations 49.8 1 1 0.9 0.00 1.0e+00 NA
Std. dev. reaction times 27.0 1 1 0.9 0.00 1.0e+00 NA
Reaction time trials AUC 15.6 1 0 0.0 0.00 1.0e+00 NA
Social responses 108.6 1 1 0.9 0.00 1.0e+00 NA
Cocaine response after cond. corrected 135.7 1 1 0.9 0.00 1.0e+00 NA
Cocaine response after cond. not corrected 176.6 1 1 0.9 0.00 1.0e+00 NA
Cocaine response before conditioning 28.6 1 1 0.9 0.00 1.0e+00 NA
Saline control response 50.6 1 1 0.9 0.00 1.0e+00 NA
Condit. Reinf. active minus inactive responses 46.4 1 1 0.9 0.00 1.0e+00 NA
Condit. Reinf. active-inactive response ratio 68.7 1 1 0.9 0.00 1.0e+00 NA
Condit. Reinf. active responses 14.2 2 0 0.0 0.00 1.0e+00 Reep5 Epb41l4a
Condit. Reinf. inactive responses 20.6 1 0 0.0 0.00 1.0e+00 NA
Condit. Reinf. lever reinforcers received 14.2 1 0 0.0 0.00 1.0e+00 Epb41l4a
Pavlov. Cond. lever latency 60.5 1 1 0.9 0.00 1.0e+00 NA
Pavlov. Cond. magazine entry latency 173.4 1 1 0.9 0.00 1.0e+00 NA
Pavlov. Cond. change in total contacts 216.7 1 1 0.9 0.00 1.0e+00 NA
Pavlov. Cond. index score 102.2 1 1 0.9 0.00 1.0e+00 NA
Pavlov. Cond. latency score 110.3 1 1 0.9 0.00 1.0e+00 NA
Pavlov. Cond. lever contacts 29.4 1 1 0.9 0.00 1.0e+00 NA
Pavlov. Cond. magazine entry number 244.9 1 1 0.9 0.00 1.0e+00 NA
Pavlov. Cond. intertrial magazine entries 106.2 1 1 0.9 0.00 1.0e+00 NA
Pavlov. Cond. lever-magazine prob. diff. 90.6 1 1 0.9 0.00 1.0e+00 NA
Pavlov. Cond. response bias 51.3 1 1 0.9 0.00 1.0e+00 NA
Conditioned reinforcement - actives 18.5 1 0 0.0 0.00 1.0e+00 NA
Intermittent access intake day 1-15 change 104.0 1 1 0.9 0.00 1.0e+00 NA
Intermittent access intake escalation 141.1 1 1 0.9 0.00 1.0e+00 NA
Intermittent access intake escalation 2 42.5 1 1 0.9 0.00 1.0e+00 NA
Intermitt. access day 1 inactive lever presses 30.6 1 1 0.9 0.00 1.0e+00 NA
Intermittent access day 1 total infusions 52.9 1 1 0.9 0.00 1.0e+00 NA
Intermittent access day 1 locomotion 27.1 1 1 0.9 0.00 1.0e+00 NA
Post-drug Anxiety 20.6 1 0 0.0 0.00 1.0e+00 NA
Progressive ratio test 2 breakpoint 61.6 1 1 0.9 0.00 1.0e+00 NA
Short access day 10 total infusions 24.0 1 1 0.9 0.00 1.0e+00 NA
Short access day 1 locomotion 17.2 1 0 0.0 0.00 1.0e+00 NA
Compulsive drug intake 45.4 1 1 0.9 0.00 1.0e+00 NA
Context. condit. distance diff. score 240.2 1 1 0.9 0.00 1.0e+00 NA
Locomotion velocity, session 1 190.8 1 1 0.9 0.00 1.0e+00 NA
Locomotion distance, session 1 609.6 1 1 0.9 0.00 1.0e+00 NA
Locomotion velocity, session 2 139.6 1 1 0.9 0.00 1.0e+00 NA
Locomotion distance, session 2 1269.9 1 1 0.9 0.00 1.0e+00 NA
Locomotion velocity, session 3 178.9 1 1 0.9 0.00 1.0e+00 NA
Locomotion distance, session 3 117.5 1 1 0.9 0.00 1.0e+00 NA
Stereotopy head waving duration, day 3 33.2 1 1 0.9 0.00 1.0e+00 NA
Locomotion velocity, session 7 98.9 1 1 0.9 0.00 1.0e+00 NA
Locomotion distance, session 7 31.8 1 1 0.9 0.00 1.0e+00 NA
Stereotopy head waving bouts, day 7 68.4 1 1 0.9 0.00 1.0e+00 NA
Stereotopy head waving duration, day 7 102.2 1 1 0.9 0.00 1.0e+00 NA
Locomotion distance, session 8 171.7 1 1 0.9 0.00 1.0e+00 NA
Degree of sensitization distance 198.5 1 1 0.9 0.00 1.0e+00 NA
Degree of sensitization stereotypy 37.5 1 1 0.9 0.00 1.0e+00 NA
Condit. Reinf. active-inactive response ratio 107.3 1 1 0.9 0.00 1.0e+00 NA
Condit. Reinf. active responses 20.0 1 0 0.0 0.00 1.0e+00 NA
Condit. Reinf. inactive responses 17.2 1 0 0.0 0.00 1.0e+00 NA
Incentive salience index mean 15.6 1 0 0.0 0.00 1.0e+00 NA
Condit. Reinf. lever presses 35.1 1 1 0.9 0.00 1.0e+00 NA
Total zone transitions, hab. session 1 673.8 1 1 0.9 0.00 1.0e+00 NA
Total locomotion distance, hab. session 1 279.4 1 1 0.9 0.00 1.0e+00 NA
Locomotion velocity, hab. session 1 349.5 1 1 0.9 0.00 1.0e+00 NA
Time in familiar zone, hab. session 2 48.9 1 1 0.9 0.00 1.0e+00 NA
Time in novel zone, hab. session 2 58.4 1 1 0.9 0.00 1.0e+00 NA
Total zone transitions, hab. session 2 421.2 1 1 0.9 0.00 1.0e+00 NA
Total locomotion distance, hab. session 2 214.3 1 1 0.9 0.00 1.0e+00 NA
Locomotion velocity, hab. session 2 225.0 1 1 0.9 0.00 1.0e+00 NA
Total zone transitions, NPP test 134.5 3 1 0.9 0.00 1.0e+00 Tfdp2 Trpc1 NA
Total locomotion distance, NPP test 269.3 1 1 0.9 0.00 1.0e+00 NA
Locomotion velocity, NPP test 317.8 1 1 0.9 0.00 1.0e+00 NA
Pavlov. Cond. magazine entry latency 95.9 1 1 0.9 0.00 1.0e+00 NA
Pavlov. Cond. change in total contacts 40.1 1 1 0.9 0.00 1.0e+00 NA
Pavlov. Cond. index score 51.9 1 1 0.9 0.00 1.0e+00 NA
Pavlov. Cond. latency score 16.6 1 0 0.0 0.00 1.0e+00 NA
Pavlov. Cond. lever contacts 16.1 1 0 0.0 0.00 1.0e+00 NA
Pavlov. Cond. magazine entry number 20.6 5 1 0.9 0.98 1.3e-05 Fbxl20 Cdk12 NA Stard3 NA
Pavlov. Cond. lever-magazine prob. diff. 88.1 1 1 0.9 0.00 1.0e+00 NA
Pavlov. Cond. response bias 52.4 1 1 0.9 0.00 1.0e+00 NA
Bone: apparent density 12.2 21 1 0.9 0.92 6.2e-24 Zfp958l1 Fry Rxfp2 Senp1 Tuba1b Cacnb3 Hdac7 Pfkm Ccdc65 Rnd1 Ddx23 Kansl2 NA NA NA Zfp958 NA NA NA Prkag1 Fkbp11
Bone surface 12.0 47 2 1.9 0.99 1.2e-189 Zfp958l1 Fry Rxfp2 Snapc2 Cers4 Asb8 Il6st Tuba1c Senp1 Zfp641 Olr1106 Spats2 Prph Ccnt1 Slc48a1 Tmem106c Rpap3 Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Adcy6 Fkbp11 Tmbim6 Hdac7 Tex49 Pfkm Ccdc65 Rnd1 Rapgef3 Ddx23 Kansl2 Kmt2d NA NA NA NA Zfp958 NA NA NA NA Prkag1 Olr1877 Olr1108 Fkbp11
Bone volume 13.2 8 1 0.9 0.98 5.7e-19 Zfp958l1 Fry Il6st NA NA Zfp958 NA Fkbp11
Bone: connectivity density 12.4 10 0 0.0 0.99 8.7e-30 Zfp958l1 Fry Rxfp2 Snapc2 Elavl1 Lrrc8e Pet100 NA Zfp958 NA
Bone: cortical area 14.6 22 1 0.9 0.97 6.5e-35 Rab11fip2 Prlhr Cacul1 Dennd10 Grk5 Il6st Acsl5 Habp2 Nhlrc2 Afap1l2 Nanos1 Dclre1a Zfp950 Ces2c Sfxn4 Ccdc57 Tcf7l2 Casp7 NA NA NA NA
Bone: cortical porosity 188.5 1 1 0.9 0.00 1.0e+00 NA
Bone: cortical porosity 155.8 1 1 0.9 0.00 1.0e+00 NA
Bone: cortical thickness 18.1 9 4 3.7 0.97 7.5e-16 Tasp1 Esf1 Ndufaf5 Rab11fip2 Ccdc57 AABR07054000.1 Ism1 NA NA
Bone: cortical thickness 20.4 2 0 0.0 0.00 1.0e+00 Ccdc57 NA
Bone: elastic displacement 28.2 1 1 0.9 0.00 1.0e+00 NA
Bone: endosteal estimation 10.1 7 1 0.9 1.00 2.4e-11 Prkca Spats2 Tuba1b NA NA RT1-CE15 Fkbp11
Bone: endosteal perimeter 11.0 1 0 0.0 0.00 1.0e+00 Prkca
Bone: final force 18.6 10 2 1.9 0.89 1.1e-04 Rab11fip2 Cacul1 Ccdc57 Spats2 Tuba1b Hdac7 NA NA NA Fkbp11
Bone: final moment 12.8 29 2 1.9 0.91 1.4e-23 Rab11fip2 Cacul1 Grk5 Il6st Tuba1c Senp1 Nanos1 Zfp950 Olr1106 Sfxn4 Ccdc57 Spats2 Tuba1b Dnajc22 Cacnb3 Tmbim6 Hdac7 Pfkm Ccdc65 Rnd1 Rapgef3 Kansl2 Kmt2d NA NA NA NA Prkag1 Fkbp11
Bone: marrow area 9.9 6 1 0.9 1.00 2.1e-09 Prkca Tuba1b NA NA RT1-CE15 Fkbp11
Bone: maximum diameter 11.3 8 0 0.0 0.99 2.4e-19 Cacul1 Acsl5 Habp2 Nhlrc2 Afap1l2 Dclre1a Tcf7l2 Casp7
Bone: maximum force 13.7 49 15 14.0 0.98 1.0e-213 Amigo2 Rab11fip2 Cacul1 Asb8 Il6st Tuba1c Senp1 Pced1b Zfp641 Olr1106 Sfxn4 Ccdc57 Spats2 Prph Ccnt1 Slc48a1 Tmem106c Rpap3 Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Vdr Adcy6 Fkbp11 Tmbim6 Hdac7 Endou Tex49 Pfkm Ccdc65 Rnd1 Rapgef3 Ddx23 Kansl2 Atf1 Kmt2d NA NA NA NA NA NA NA Prkag1 Olr1877 Olr1108 Fkbp11
Bone: maximum moment 13.7 48 17 15.9 0.99 1.7e-228 Amigo2 Cacul1 Asb8 Il6st Tuba1c Senp1 Pced1b Zfp641 Olr1106 Sfxn4 Ccdc57 Spats2 Prph Ccnt1 Slc48a1 Tmem106c Rpap3 Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Vdr Adcy6 Fkbp11 Tmbim6 Hdac7 Endou Tex49 Pfkm Ccdc65 Rnd1 Rapgef3 Ddx23 Kansl2 Atf1 Kmt2d NA NA NA NA NA NA NA Prkag1 Olr1877 Olr1108 Fkbp11
Bone: minimum diameter 13.9 13 1 0.9 0.95 1.3e-10 Prkca Tuba1c Prph Tuba1b Cacnb3 Adcy6 Ccdc65 Kmt2d NA NA NA NA Fkbp11
Bone: periosteal estimation 12.0 55 19 17.8 0.96 9.0e-173 Amigo2 Rab11fip2 Cacul1 Asb8 Grk5 Il6st Acsl5 Nhlrc2 Tuba1c Senp1 Pced1b Nanos1 Zfp641 Zfp950 Olr1106 Sfxn4 Tcf7l2 Spats2 Prph Ccnt1 Slc48a1 Tmem106c Rpap3 Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Vdr Adcy6 Fkbp11 Tmbim6 Hdac7 Casp7 Endou Tex49 Pfkm Ccdc65 Rnd1 Rapgef3 Ddx23 Kansl2 Kmt2d NA NA NA NA Olr1107 NA NA NA Prkag1 Olr1877 Olr1108 Fkbp11
Bone: periosteal perimeter 12.2 52 2 1.9 0.97 8.5e-136 Rab11fip2 Cacul1 Asb8 Dennd10 Grk5 Acsl5 Habp2 Nrap Nhlrc2 Adrb1 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Tuba1c Senp1 Pced1b Nanos1 Dclre1a Zfp641 Zfp950 Olr1106 Ces2c Sfxn4 AABR07007032.1 Tcf7l2 Prph Ccnt1 Slc48a1 Tmem106c Rpap3 Tuba1b Cacnb3 Vdr Adcy6 Hdac7 Casp7 Endou Pfkm Ccdc65 Rnd1 Rapgef3 Kansl2 Kmt2d NA NA NA NA Prkag1 Olr1877 Fkbp11
Bone: post-yield work 124.3 1 1 0.9 0.00 1.0e+00 NA
Bone: stiffness 16.9 44 35 32.7 0.99 1.2e-268 Amigo2 Asb8 Tuba1c Senp1 Pced1b Zfp641 Olr1106 Ccdc57 Spats2 Prph Ccnt1 Slc48a1 Tmem106c Rpap3 Tuba1b Dnajc22 Dhh Cacnb3 Rhebl1 Vdr Adcy6 Fkbp11 Tmbim6 Hdac7 Endou Tex49 Pfkm Ccdc65 Rnd1 Rapgef3 Ddx23 Kansl2 Atf1 Kmt2d NA NA NA Olr1107 NA NA Prkag1 Olr1877 Olr1108 Fkbp11
Bone: tissue strength 136.0 1 1 0.9 0.00 1.0e+00 NA
Bone: trabecular number 64.1 1 1 0.9 0.00 1.0e+00 NA
Bone: trabecular thickness 15.3 2 0 0.0 0.00 1.0e+00 Cacul1 Sfxn4
Bone: trabecular tissue density 66.6 1 1 0.9 0.00 1.0e+00 NA
Delta time in open arm before/after self-admin 40.2 1 1 0.9 0.00 1.0e+00 NA
Time in closed arm before self-admin 78.0 1 1 0.9 0.00 1.0e+00 NA
Time in closed arm after self-admin 40.2 1 1 0.9 0.00 1.0e+00 NA
Time in open arm after self-admin 31.3 1 1 0.9 0.00 1.0e+00 NA
Time >=10cm from walls, locomotor time 1 19.5 1 0 0.0 0.00 1.0e+00 NA
Rest time, locomotor task time 1 17.5 1 0 0.0 0.00 1.0e+00 Nbeal2
Time >=10cm from walls, locomotor time 2 22.5 2 1 0.9 0.00 1.0e+00 Rnf8 NA
Weight adjusted by age 25.0 1 1 0.9 0.00 1.0e+00 NA
Food seeking constrained by brief footshock 22.2 1 1 0.9 1.00 8.6e-09 RGD1359108
Run reversals in cocaine runway, males 39.3 1 1 0.9 0.00 1.0e+00 NA
Latency to leave start box in cocaine runway 18.8 1 0 0.0 0.00 1.0e+00 NA
Cd content in liver 239.3 1 1 0.9 0.00 1.0e+00 NA
Co content in liver 143.3 1 1 0.9 0.00 1.0e+00 NA
K content in liver 87.3 1 1 0.9 0.00 1.0e+00 NA
Mn content in liver 207.1 1 1 0.9 0.00 1.0e+00 NA
Rb content in liver 31.4 1 1 0.9 0.00 1.0e+00 NA
Se content in liver 47.0 1 1 0.9 0.00 1.0e+00 NA
Zn content in liver 46.0 1 1 0.9 0.00 1.0e+00 NA

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 64 3.02 4.6
Adipose alternative TSS 22 1.36 4.0
Adipose gene expression 121 1.46 3.9
Adipose isoform ratio 59 2.09 4.3
Adipose intron excision ratio 44 1.51 3.8
Adipose mRNA stability 59 1.71 4.1
BLA alternative polyA 12 1.00 4.3
BLA alternative TSS 10 1.19 4.1
BLA gene expression 116 1.91 4.3
BLA isoform ratio 29 1.65 4.4
BLA intron excision ratio 69 2.31 4.5
BLA mRNA stability 50 2.47 4.5
Brain alternative polyA 29 1.45 4.2
Brain alternative TSS 33 1.92 4.4
Brain gene expression 159 1.76 4.1
Brain isoform ratio 60 1.90 4.2
Brain intron excision ratio 103 1.91 4.3
Brain mRNA stability 74 1.70 4.0
Eye alternative polyA 0 0.00 4.2
Eye alternative TSS 7 2.92 4.1
Eye gene expression 18 1.60 4.2
Eye isoform ratio 5 1.41 4.3
Eye intron excision ratio 13 2.12 4.8
Eye mRNA stability 3 1.29 4.3
IL alternative polyA 12 1.97 4.8
IL alternative TSS 3 1.04 4.4
IL gene expression 61 1.67 4.3
IL isoform ratio 18 2.28 4.7
IL intron excision ratio 12 1.24 4.4
IL mRNA stability 23 2.07 4.3
LHb alternative polyA 9 1.57 4.7
LHb alternative TSS 2 0.57 3.8
LHb gene expression 59 1.84 4.3
LHb isoform ratio 5 0.66 4.4
LHb intron excision ratio 9 0.87 4.5
LHb mRNA stability 24 2.32 4.5
Liver alternative polyA 33 2.20 4.3
Liver alternative TSS 21 1.39 4.0
Liver gene expression 103 1.43 4.0
Liver isoform ratio 40 1.67 4.3
Liver intron excision ratio 68 1.56 3.9
Liver mRNA stability 51 2.08 4.2
NAcc alternative polyA 18 1.38 4.4
NAcc alternative TSS 14 1.51 4.2
NAcc gene expression 112 1.78 4.3
NAcc isoform ratio 32 1.70 4.5
NAcc intron excision ratio 58 1.90 4.4
NAcc mRNA stability 44 1.95 4.4
OFC alternative polyA 10 1.71 4.9
OFC alternative TSS 6 1.88 4.6
OFC gene expression 69 1.86 4.4
OFC isoform ratio 8 0.98 4.5
OFC intron excision ratio 18 1.79 4.8
OFC mRNA stability 22 2.04 4.7
PL alternative polyA 15 1.05 4.2
PL alternative TSS 22 1.87 4.2
PL gene expression 137 1.86 4.2
PL isoform ratio 41 1.86 4.5
PL intron excision ratio 89 2.48 4.6
PL mRNA stability 54 1.85 4.2

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.