Tuba1c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression ENSRNOG00000021438 0.04 0.04 9.0e-04 0.02 0.02 0.02 0.02 2.2e-03 3.1e-03 2.1e-03 3.9e-03
2 PL gene expression ENSRNOG00000021438 0.04 0.04 3.1e-03 0.03 0.03 0.02 0.02 4.5e-03 3.1e-03 7.0e-03 7.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
BMI with tail4.915.917.14.1-3.8
BMI without tail0.10.10.20.50.1
Body weight6.828.630.65.5-5.2
Epididymis fat weight0.20.40.40.6-0.6
Glucose0.20.30.50.7-0.2
Heart weight0.00.00.10.2-0.3
Left kidney weight0.30.81.10.7-1.0
Right kidney weight2.77.67.72.8-2.8
Tail length0.10.20.3-0.20.5
Length with tail2.07.27.32.7-2.7
Length without tail7.616.617.14.0-4.1
Liver weight, left2.33.74.32.1-1.7
Liver weight, right1.82.93.41.8-1.6
Parametrial fat weight2.24.34.3-2.12.1
Retroperitoneal fat weight0.41.31.7-1.01.3
Intraocular pressure7.710.810.9-3.33.3
Extensor digitorum longus weight4.618.621.24.6-4.0
Soleus weight0.72.02.21.5-1.4
Tibialis anterior weight1.65.47.82.8-1.7
Tibia length8.122.724.24.9-4.6
Number of licking bursts0.20.30.5-0.10.7
Food consumed during 24 hour testing period1.72.02.11.4-1.4
Times rat made contact with spout0.10.10.1-0.20.3
Mean time between licks in bursts0.20.30.5-0.70.3
Mean num. licks in bursts0.10.10.2-0.4-0.1
Std. dev. time between licks in bursts0.91.11.4-0.91.2
Water consumed over 24 hours0.00.00.00.0-0.1
Indifference point 0 sec2.13.43.7-1.81.9
Indifference point AUC0.10.20.3-0.20.5
Indifference point function ln k3.54.95.52.1-2.4
Indifference point function log k3.54.95.52.1-2.4
Delay discounting total patch changes 0 sec2.03.23.5-1.71.9
Delay discounting total patch changes 12 sec1.72.22.8-1.31.7
Delay discounting total patch changes 18 sec3.74.95.7-2.02.4
Delay discounting total patch changes 24 sec1.82.32.7-1.41.6
Delay discounting total patch changes 6 sec2.23.33.9-1.72.0
Delay discounting time to switch 0 sec2.33.53.6-1.81.9
Delay discounting water rate 0 sec2.94.54.82.1-2.2
Delay discounting water rate 12 sec3.55.25.72.2-2.4
Delay discounting water rate 18 sec0.30.40.50.7-0.6
Delay discounting water rate 24 sec3.14.24.62.0-2.1
Delay discounting water rate 6 sec3.55.05.52.1-2.3
Locomotor activity1.11.71.9-1.21.4
Locomotor testing distance2.94.85.2-2.12.3
Locomotor testing rearing2.03.13.8-1.51.9
Light reinforcement 12.54.55.6-1.92.4
Light reinforcement 20.91.11.3-1.01.1
Reaction time number correct1.11.52.20.9-1.5
Reaction time mean minus median8.210.711.3-3.23.4
Reaction time mean minus median AUC5.97.67.9-2.72.8
Reaction time num false alarms1.72.32.4-1.61.5
Reaction time num false alarms AUC2.43.33.4-1.81.8
Reaction time trials correct on left1.11.52.20.9-1.5
Reaction time trials on left0.81.11.70.7-1.3
Reaction time mean0.60.80.9-0.81.0
Reaction time mean AUC0.30.40.5-0.50.7
Median of all reaction times0.00.00.10.3-0.1
Reaction time omissions10.414.014.0-3.73.7
Reaction time false alarm rate2.43.43.8-1.72.0
Reaction time premature initiation rate5.57.49.1-2.43.0
Reaction time premature initiations2.63.84.4-1.82.1
Std. dev. reaction times6.18.48.8-2.83.0
Reaction time trials completed0.81.11.70.7-1.3
Reaction time trials AUC1.31.92.81.0-1.7
Social response proportion0.10.10.1-0.20.4
Social responses6.98.910.5-2.73.2
Social time0.00.00.0-0.20.0
Conditioned locomotion0.00.00.00.0-0.2
Cocaine response after cond. corrected0.00.00.0-0.20.0
Cocaine response after cond. not corrected0.60.70.8-0.90.8
Cocaine response before conditioning3.44.24.2-2.02.1
Saline control response0.10.20.20.4-0.4
Condit. Reinf. active minus inactive responses0.00.00.0-0.00.1
Condit. Reinf. active-inactive response ratio0.30.30.3-0.50.6
Condit. Reinf. active responses0.10.20.3-0.20.5
Condit. Reinf. inactive responses0.50.60.8-0.60.9
Condit. Reinf. lever presses0.00.00.10.30.0
Condit. Reinf. lever reinforcers received0.40.50.8-0.60.9
Pavlov. Cond. lever latency0.00.00.0-0.1-0.1
Pavlov. Cond. magazine entry latency1.11.31.31.1-1.1
Pavlov. Cond. change in total contacts1.82.63.21.8-1.4
Pavlov. Cond. index score0.60.81.01.0-0.8
Pavlov. Cond. latency score0.60.80.91.0-0.8
Pavlov. Cond. lever contacts0.10.10.2-0.10.4
Pavlov. Cond. magazine entry number2.53.13.4-1.81.7
Pavlov. Cond. intertrial magazine entries5.77.37.6-2.82.6
Pavlov. Cond. lever-magazine prob. diff.1.11.41.71.3-1.1
Pavlov. Cond. response bias0.00.00.00.20.1
Conditioned reinforcement - actives1.51.51.7-1.11.3
Conditioned reinforcement - inactives2.02.22.4-1.41.6
Conditioned locomotion0.30.30.5-0.50.7
Intermittent access intake day 1-15 change1.11.11.7-0.71.3
Intermittent access intake escalation0.80.81.2-0.51.1
Intermittent access intake escalation 21.31.31.9-0.91.4
Intermitt. access day 1 inactive lever presses2.83.13.4-1.81.7
Intermitt. access day 15 inactive lever presses1.31.41.4-1.21.2
Intermitt. access escalation Index0.20.10.2-0.30.5
Intermittent access day 1 total infusions1.21.31.3-1.11.2
Intermittent access day 15 total infusions2.22.53.4-1.21.8
Intermittent access terminal intake (last 3 days)2.62.83.6-1.41.9
Intermittent access total infusions2.42.63.3-1.41.8
Intermittent access day 1 locomotion0.80.80.9-0.81.0
Intermittent access day 15 total locomotion1.21.31.9-0.81.4
Intermittent access total locomotion2.73.14.0-1.52.0
Intermittent access standard deviation0.40.50.6-0.50.8
Cocaine induced anxiety1.41.62.11.4-1.1
Post-drug Anxiety5.56.16.42.5-2.4
Baseline Anxiety0.91.01.10.9-1.0
Lifetime Intake2.12.43.2-1.31.8
Incentive Sensitization - Responses0.00.00.10.3-0.0
Incentive Sensitization - Breakpoint0.00.00.00.20.1
Progressive ratio test 1 active lever presses4.34.45.3-1.92.3
Progressive ratio test 1 breakpoint3.84.04.8-1.82.2
Progressive ratio test 1 inactive lever presses3.43.74.1-1.82.0
Progressive ratio test 2 active lever presses2.12.22.9-1.21.7
Progressive ratio test 2 breakpoint2.73.03.8-1.52.0
Progressive ratio test 2 inactive lever presses2.32.73.2-1.41.8
Total sessions with >9 infusions0.70.81.3-0.61.1
Short access day 1 total inactive lever presses1.21.31.8-0.91.3
Short access day 10 total inactive lever presses0.20.20.3-0.50.4
Short access day 1 total infusions0.00.00.10.00.3
Short access day 10 total infusions0.80.81.2-0.71.1
Short access total infusions0.40.40.8-0.30.9
Short access day 1 locomotion0.10.10.10.00.4
Short access day 10 total locomotion0.10.10.1-0.30.4
Short access total locomotion0.30.30.5-0.30.7
Compulsive drug intake0.70.71.20.6-1.1
One hour access (0.3 mA shock)0.20.20.4-0.10.6
One hour access (shock baseline)0.10.20.30.20.6
Number of responses in last shaping day0.30.30.50.7-0.0
Context. condit. distance diff. score0.30.40.50.7-0.5
Locomotion velocity, session 11.31.41.7-1.31.1
Locomotion distance, session 13.54.55.4-2.31.9
Locomotion velocity, session 20.50.61.0-1.00.5
Locomotion distance, session 22.94.25.1-2.21.8
Locomotion velocity, session 34.35.05.3-2.32.2
Locomotion distance, session 35.56.06.0-2.42.4
Stereotopy head waving bouts, day 30.91.11.40.9-1.2
Stereotopy head waving duration, day 30.30.40.70.3-0.9
Locomotion velocity, session 70.20.30.3-0.40.6
Locomotion distance, session 71.51.92.4-1.21.6
Stereotopy head waving bouts, day 70.81.01.10.9-1.0
Stereotopy head waving duration, day 71.11.41.51.1-1.2
Locomotion velocity, session 80.00.00.0-0.2-0.1
Locomotion distance, session 81.31.92.0-1.41.3
Degree of sensitization distance0.70.70.80.9-0.7
Degree of sensitization stereotypy0.20.20.20.5-0.4
Condit. Reinf. active minus inactive responses0.20.20.3-0.60.2
Condit. Reinf. active-inactive response ratio0.10.10.20.2-0.5
Condit. Reinf. active responses0.81.01.3-1.10.8
Condit. Reinf. inactive responses2.83.33.3-1.81.8
Incentive salience index mean0.00.00.00.0-0.1
Condit. Reinf. lever presses0.10.20.20.4-0.4
Time in familiar zone, hab. session 10.50.50.7-0.90.5
Time in novel zone, hab. session 10.50.40.60.8-0.5
Total zone transitions, hab. session 10.40.60.7-0.80.7
Total locomotion distance, hab. session 10.00.00.1-0.2-0.1
Locomotion velocity, hab. session 10.00.00.0-0.1-0.2
Time in familiar zone, hab. session 20.20.20.40.2-0.6
Time in novel zone, hab. session 20.20.20.3-0.20.5
Total zone transitions, hab. session 20.50.60.9-0.90.6
Total locomotion distance, hab. session 20.20.30.5-0.70.3
Locomotion velocity, hab. session 20.10.20.3-0.50.2
Novel to familiar place preference ratio2.32.43.01.7-1.4
Novelty place preference1.81.82.31.5-1.2
Time in novel zone, NPP test1.51.62.01.4-1.1
Total zone transitions, NPP test1.62.32.7-1.71.4
Total locomotion distance, NPP test2.12.93.5-1.91.5
Locomotion velocity, NPP test1.21.72.1-1.51.1
Pavlov. Cond. lever latency0.00.10.1-0.0-0.3
Pavlov. Cond. magazine entry latency0.00.00.00.1-0.0
Pavlov. Cond. change in total contacts0.10.10.20.5-0.1
Pavlov. Cond. index score0.10.10.30.5-0.1
Pavlov. Cond. latency score0.10.10.20.50.0
Pavlov. Cond. lever contacts0.30.30.6-0.30.8
Pavlov. Cond. magazine entry number0.00.00.0-0.1-0.2
Pavlov. Cond. intertrial magazine entries0.70.81.3-1.20.6
Pavlov. Cond. lever-magazine prob. diff.0.30.40.60.8-0.4
Pavlov. Cond. response bias0.00.00.1-0.00.3
Bone: apparent density10.216.817.74.0-4.2
Bone surface11.921.021.94.5-4.7
Bone volume8.814.815.73.7-4.0
Bone: connectivity density7.311.412.23.3-3.5
Bone: cortical apparent density0.20.30.4-0.50.6
Bone: cortical area10.115.315.94.0-3.9
Bone: cortical porosity1.01.11.3-1.10.9
Bone: cortical porosity1.51.61.8-1.31.2
Bone: cortical thickness3.76.16.52.5-2.4
Bone: cortical thickness0.30.30.50.7-0.3
Bone: cortical tissue density0.30.50.5-0.60.7
Bone: elastic displacement5.25.96.7-2.62.2
Bone: elastic work0.10.10.1-0.4-0.1
Bone: endosteal estimation7.917.117.34.1-4.2
Bone: endosteal perimeter7.615.617.04.1-3.8
Bone: final force9.816.117.23.9-4.1
Bone: final moment10.116.718.23.9-4.3
Bone: marrow area7.816.716.84.1-4.1
Bone: maximum diameter4.37.98.93.0-2.6
Bone: maximum force14.224.726.04.8-5.1
Bone: maximum moment14.425.127.04.8-5.2
Bone: minimum diameter9.617.818.44.3-4.1
Bone: periosteal estimation12.625.726.35.1-5.0
Bone: periosteal perimeter10.918.118.84.3-4.2
Bone: post-yield work8.611.712.23.4-3.5
Bone: stiffness17.427.527.75.2-5.3
Bone: tissue strength0.90.91.20.7-1.1
Bone: trabecular number6.09.310.52.9-3.2
Bone: trabecular spacing2.22.83.2-1.61.8
Bone: trabecular thickness0.10.10.1-0.30.4
Bone: trabecular tissue density0.10.10.1-0.30.3
Breakpoint value in progressive ratio session0.30.30.30.6-0.5
Distance traveled before self-admin1.21.31.3-1.11.1
Distance traveled after self-admin0.30.30.4-0.70.4
Delta time in closed arm before/after self-admin0.20.20.30.4-0.5
Delta time in open arm before/after self-admin4.94.64.9-2.22.1
Diff in mean of infusions in LGA sessions1.41.61.91.1-1.4
Extinction: sum of active levers before priming0.40.40.50.5-0.7
Active lever presses in extinction session 60.40.40.40.6-0.7
Delta distance traveled before/after self-admin0.00.00.10.1-0.3
Delta ambulatory time before/after self-admin0.00.00.00.1-0.1
Time in closed arm before self-admin1.82.02.41.6-1.3
Time in closed arm after self-admin0.80.80.90.9-0.8
Time in open arm before self-admin0.80.91.01.0-0.9
Time in open arm after self-admin0.40.40.5-0.70.5
Sum of active levers in priming session hrs 5-60.00.00.0-0.20.2
Time to tail flick, vehicle, before self-admin1.21.21.5-1.20.9
Time to tail flick, vehicle, after self-admin0.20.30.30.5-0.5
Time to tail flick, test, before self-admin0.60.50.8-0.90.5
Time to tail flick, test, after self-admin0.20.20.20.5-0.4
Delta time to tail flick, vehicle, before/after SA0.50.50.70.8-0.6
Delta time to tail flick, test, before/after SA0.30.30.40.6-0.4
Ambulatory time before self-admin4.14.34.4-2.12.1
Ambulatory time after self-admin1.92.12.1-1.41.5
Total heroin consumption2.22.63.01.7-1.5
Area under the delay curve0.91.01.00.9-1.0
Delay disc. indifference point, 0s delay1.11.21.41.0-1.2
Delay disc. indifference point, 16s delay1.01.01.11.1-1.0
Delay disc. indifference point, 2s delay1.21.41.71.0-1.3
Delay disc. indifference point, 24s delay1.61.61.81.3-1.2
Delay disc. indifference point, 4s delay0.20.20.30.4-0.5
Delay disc. indifference point, 8s delay2.62.72.71.6-1.6
Delay discount exponential model param0.80.90.9-0.91.0
Delay discount hyperbolic model param0.80.80.9-0.91.0
Fecal boli incidents, locomotor time 12.32.42.6-1.61.5
Change in fecal boli incidents, locomotor task1.11.11.50.8-1.2
Time >=10cm from walls, locomotor time 10.10.10.10.4-0.4
Bouts of movement, locomotor time 10.00.00.1-0.3-0.1
Total resting periods, locomotor time 10.40.40.7-0.80.4
Rest time, locomotor task time 10.40.50.6-0.80.6
Distance moved, locomotor task time 10.10.10.20.4-0.2
Vertical activity count, locomotor time 11.51.61.81.3-1.2
Time >=10cm from walls, locomotor time 20.80.81.0-1.00.8
Bouts of movement, locomotor time 22.52.72.91.6-1.7
Total resting periods, locomotor time 22.93.13.31.7-1.8
Rest time, locomotor task time 20.00.00.10.3-0.1
Distance moved, locomotor task time 20.10.10.2-0.40.3
Vertical activity count, locomotor time 20.00.00.10.3-0.1
Weight adjusted by age2.52.83.31.8-1.5
Seeking ratio, delayed vs. immediate footshock0.30.30.30.5-0.6
Locomotion in novel chamber0.60.70.70.8-0.8
Locomotion in novel chamber post-restriction0.00.00.00.1-0.1
Progressive ratio0.00.00.0-0.00.2
Food seeking constrained by brief footshock0.30.30.4-0.50.7
Seeking ratio, punishment vs. effort0.00.00.0-0.10.1
Run reversals in cocaine runway, females0.00.00.00.1-0.0
Run reversals in cocaine runway, males1.61.61.6-1.31.2
Latency to leave start box in cocaine runway0.00.00.00.00.1
Latency to leave start box in cocaine runway, F1.71.82.0-1.31.4
Latency to leave start box in cocaine runway, M2.22.12.11.4-1.4
Cd content in liver0.50.60.8-0.60.9
Co content in liver0.30.40.7-0.30.8
Cu content in liver0.70.80.80.9-0.9
Fe content in liver0.20.20.4-0.10.6
K content in liver0.20.20.30.5-0.5
Mg content in liver0.00.00.0-0.10.1
Mn content in liver0.00.10.1-0.1-0.3
Na content in liver0.00.00.1-0.10.2
Rb content in liver0.30.30.5-0.40.7
Se content in liver0.60.70.8-0.80.9
Sr content in liver0.50.50.70.8-0.5
Zn content in liver1.61.82.2-1.21.5