Hub : Genes

Apc

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA intron excision ratio chr18:25828942:25864257 0.08 0.06 5.2e-03 0.04 0.04 0.04 0.04 2.1e-03 2.8e-03 2.0e-03 3.7e-03
2 Brain gene expression ENSRNOG00000020423 0.04 0.03 1.2e-04 0.01 0.03 0.03 0.01 1.9e-02 6.0e-04 2.0e-03 2.6e-02
3 Brain intron excision ratio chr18:25828942:25871423 0.05 0.03 5.8e-07 0.07 0.07 0.07 0.07 4.0e-07 3.4e-07 2.5e-07 8.3e-07
4 Brain intron excision ratio chr18:25864409:25869179 0.03 0.03 6.8e-04 0.01 0.02 0.02 0.02 5.4e-02 2.5e-03 5.4e-03 4.6e-03
5 Brain intron excision ratio chr18:25864409:25871423 0.07 0.06 5.1e-03 0.02 0.02 0.01 0.01 1.1e-02 7.0e-03 7.4e-02 2.0e-02
6 Brain intron excision ratio chr18:25869365:25871423 0.02 0.02 1.5e-03 0.02 0.03 0.01 0.02 3.2e-03 1.7e-03 5.6e-02 3.1e-03
7 Eye isoform ratio ENSRNOT00000027691 0.31 0.17 4.5e-03 0.07 0.03 -0 0.02 3.1e-02 1.2e-01 3.8e-01 1.4e-01
8 Eye isoform ratio ENSRNOT00000102176 0.28 0.18 6.3e-03 0.11 0.07 0.07 0.05 9.7e-03 2.9e-02 3.6e-02 5.5e-02
9 PL gene expression ENSRNOG00000020423 0.05 0.03 6.9e-05 0.03 0.03 0.02 0.03 4.1e-03 1.4e-03 5.6e-03 1.6e-03
10 PL isoform ratio ENSRNOT00000027691 0.03 0.02 1.0e-02 0.03 0.02 0 0.02 3.1e-03 1.4e-02 2.6e-01 1.2e-02
11 PL isoform ratio ENSRNOT00000102176 0.03 0.02 6.3e-03 0.03 0.02 0.01 0.03 1.2e-03 7.1e-03 1.0e-01 2.7e-03
12 PL intron excision ratio chr18:25828942:25871423 0.04 0.03 2.2e-03 0.01 0.03 0.02 0.02 2.9e-02 3.0e-03 7.5e-03 7.3e-03
13 PL intron excision ratio chr18:25855715:25856649 0.05 0.03 1.4e-04 0.05 0.05 0.04 0.05 1.6e-04 1.5e-04 3.9e-04 1.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
BMI with tail6.721.827.74.6-3.74.9-3.04.6-4.6-4.54.9-4.7-5.25.25.3-4.9
BMI without tail4.910.314.63.6-2.63.1-2.32.7-3.3-3.03.4-3.2-3.63.63.8-3.4
Body weight6.627.836.64.1-4.25.8-3.45.7-5.2-4.95.8-5.3-6.06.05.7-5.6
Epididymis fat weight4.510.613.33.6-3.53.3-3.22.4-3.4-3.33.0-3.5-3.13.13.4-3.4
Glucose7.511.413.12.8-3.23.5-3.13.2-3.5-3.53.6-3.4-3.53.53.5-3.5
Heart weight2.94.28.60.8-1.22.3-0.82.9-1.8-1.82.5-1.9-2.52.52.1-2.1
Left kidney weight0.20.71.7-0.3-0.51.1-0.41.3-0.60.11.2-0.7-1.01.00.6-0.8
Right kidney weight0.20.51.4-0.4-0.21.00.11.2-0.30.11.1-0.5-0.90.90.3-0.6
Tail length0.10.30.60.8-0.60.5-0.60.2-0.6-0.10.7-0.5-0.60.60.7-0.6
Length with tail0.72.54.30.6-1.11.8-0.82.1-1.5-1.51.9-1.5-1.91.91.6-1.7
Length without tail0.71.53.60.0-0.71.5-0.51.9-1.0-1.41.3-1.2-1.41.41.0-1.2
Liver weight, left0.10.20.8-0.4-0.80.3-0.90.1-0.1-0.00.4-0.4-0.10.1-0.4-0.1
Liver weight, right0.91.53.6-0.20.6-1.30.4-1.91.21.3-1.41.11.3-1.3-1.41.2
Parametrial fat weight1.02.05.22.3-1.60.8-1.80.0-1.5-1.91.0-1.3-0.90.91.5-1.2
Retroperitoneal fat weight3.712.314.23.7-3.23.4-3.02.9-3.6-3.73.7-3.6-3.53.53.8-3.6
Intraocular pressure4.56.38.12.7-1.92.6-1.52.4-2.4-2.52.5-2.5-2.92.92.8-2.7
Extensor digitorum longus weight1.87.39.12.8-2.12.9-1.82.5-2.7-2.73.0-2.8-2.92.93.0-2.8
Soleus weight1.54.27.82.8-1.91.9-1.61.5-1.9-2.81.9-2.3-1.81.82.0-2.0
Tibialis anterior weight0.93.34.71.9-1.32.1-0.91.8-1.7-1.51.9-1.8-2.22.22.0-1.9
Tibia length0.92.43.81.1-1.11.8-0.91.8-1.6-1.21.5-1.4-1.91.91.9-1.7
Number of licking bursts1.11.33.0-1.51.0-0.91.0-0.61.31.7-0.81.10.8-0.8-1.41.1
Food consumed during 24 hour testing period1.31.53.3-0.2-0.81.5-0.61.8-1.2-0.71.4-1.1-1.61.61.2-1.2
Times rat made contact with spout0.20.20.5-0.1-0.20.6-0.30.5-0.50.70.7-0.1-0.50.50.6-0.5
Mean time between licks in bursts0.40.51.30.5-0.40.8-0.20.9-0.50.10.7-0.6-1.21.20.6-0.8
Mean num. licks in bursts1.51.83.51.6-1.11.3-1.20.9-1.6-1.41.3-1.2-1.31.31.9-1.5
Std. dev. time between licks in bursts0.00.10.2-0.50.2-0.20.20.20.20.4-0.00.10.1-0.1-0.30.2
Water consumed over 24 hours0.30.32.1-1.50.50.10.50.70.10.80.20.4-0.30.30.00.0
Indifference point 0 sec2.33.75.8-0.91.8-2.11.5-2.42.02.3-1.82.02.0-2.0-1.92.1
Indifference point AUC3.43.95.3-2.31.8-2.01.7-1.52.11.5-2.32.02.1-2.1-2.32.1
Indifference point function ln k8.111.415.13.5-3.03.4-2.72.8-3.4-3.33.9-3.4-3.63.63.7-3.5
Indifference point function log k8.111.415.13.5-3.03.4-2.72.8-3.4-3.33.9-3.4-3.63.63.7-3.5
Delay discounting total patch changes 0 sec2.33.65.3-1.01.7-2.01.4-2.32.02.3-1.82.02.0-2.0-2.02.0
Delay discounting total patch changes 12 sec9.612.815.4-2.93.2-3.52.9-3.63.73.9-3.93.73.7-3.7-3.83.7
Delay discounting total patch changes 18 sec4.76.28.0-2.72.4-2.52.1-1.92.42.8-2.82.72.3-2.3-2.52.5
Delay discounting total patch changes 24 sec3.34.25.1-1.72.1-2.01.9-1.92.12.3-2.12.22.0-2.0-2.12.1
Delay discounting total patch changes 6 sec3.85.97.1-2.12.3-2.42.0-2.52.52.7-2.32.62.5-2.5-2.62.5
Delay discounting time to switch 0 sec0.10.20.70.8-0.50.3-0.50.0-0.5-0.00.4-0.4-0.30.30.6-0.5
Delay discounting water rate 0 sec0.00.00.0-0.20.10.00.10.10.0-0.10.00.1-0.10.10.00.0
Delay discounting water rate 12 sec0.60.82.00.3-0.61.1-0.61.0-0.9-0.41.4-0.7-1.21.21.0-1.0
Delay discounting water rate 18 sec0.30.41.00.9-0.80.5-1.0-0.1-0.6-0.40.6-0.5-0.40.40.5-0.6
Delay discounting water rate 24 sec0.40.61.70.7-1.10.8-1.30.2-0.9-0.30.4-0.6-0.50.50.7-0.8
Delay discounting water rate 6 sec0.10.20.30.1-0.50.5-0.60.3-0.5-0.10.1-0.3-0.50.50.4-0.5
Locomotor activity0.20.31.4-0.51.0-0.41.20.10.40.4-0.30.40.2-0.2-0.10.4
Locomotor testing distance0.10.10.4-0.50.6-0.10.70.20.20.10.00.20.1-0.10.00.2
Locomotor testing rearing0.60.91.3-0.81.1-0.91.0-0.81.01.2-0.91.00.9-0.9-0.90.9
Light reinforcement 11.52.84.9-0.61.5-1.71.2-2.21.52.1-1.81.81.8-1.8-1.51.6
Light reinforcement 23.64.76.9-1.92.1-2.31.9-2.12.02.1-2.62.32.4-2.4-1.92.2
Reaction time number correct1.42.03.10.8-1.21.6-1.11.6-1.4-1.21.3-1.3-1.71.71.5-1.6
Reaction time mean minus median0.20.30.8-0.10.9-0.70.9-0.50.40.3-0.40.70.5-0.5-0.10.5
Reaction time mean minus median AUC0.10.10.50.50.2-0.1-0.0-0.2-0.4-0.30.20.1-0.10.10.7-0.2
Reaction time num false alarms0.91.22.31.3-1.20.8-1.30.4-1.3-1.50.3-1.1-0.90.91.4-1.1
Reaction time num false alarms AUC1.52.13.71.8-1.61.1-1.80.6-1.7-1.90.6-1.4-1.21.21.8-1.4
Reaction time trials correct on left1.42.03.10.8-1.21.6-1.11.6-1.4-1.21.3-1.3-1.71.71.5-1.6
Reaction time trials on left1.42.03.10.9-1.21.6-1.11.5-1.4-1.21.4-1.4-1.81.81.5-1.6
Reaction time mean0.40.51.41.1-0.40.5-0.40.4-0.8-1.20.2-0.7-0.70.71.1-0.7
Reaction time mean AUC0.20.31.21.1-0.30.3-0.4-0.0-0.6-0.9-0.1-0.4-0.40.40.9-0.5
Median of all reaction times0.91.32.61.5-1.00.9-0.90.6-1.2-1.60.5-1.1-1.11.11.4-1.1
Reaction time omissions0.00.10.20.40.2-0.30.2-0.50.1-0.0-0.30.20.0-0.00.10.1
Reaction time false alarm rate0.40.51.41.1-0.80.3-1.0-0.0-0.8-1.2-0.0-0.7-0.30.30.9-0.5
Reaction time premature initiation rate2.63.59.7-3.11.7-1.31.8-0.52.12.4-1.11.81.3-1.3-2.51.8
Reaction time premature initiations1.01.45.3-2.30.9-0.61.0-0.11.31.6-0.51.10.5-0.5-1.61.0
Std. dev. reaction times0.20.31.10.50.00.40.00.5-0.6-0.60.2-0.2-0.70.71.0-0.6
Reaction time trials completed1.42.03.10.9-1.21.6-1.11.5-1.4-1.21.4-1.4-1.81.81.5-1.6
Reaction time trials AUC1.42.03.10.8-1.21.6-1.11.6-1.4-1.21.4-1.3-1.81.81.5-1.6
Social response proportion1.01.14.42.1-0.70.7-0.50.2-0.9-1.70.7-0.9-1.01.01.2-0.8
Social responses0.60.82.60.10.3-1.10.0-1.60.70.1-1.10.71.2-1.2-0.91.0
Social time0.40.64.32.1-0.50.1-0.4-0.9-0.4-0.70.6-0.5-0.10.10.6-0.3
Conditioned locomotion0.10.10.2-0.20.20.30.30.4-0.00.3-0.00.1-0.30.30.1-0.1
Cocaine response after cond. corrected1.11.22.01.4-1.21.2-1.40.4-1.2-0.51.1-0.9-1.01.01.2-1.2
Cocaine response after cond. not corrected0.20.20.80.9-0.50.3-0.8-0.6-0.30.30.5-0.1-0.10.10.2-0.3
Cocaine response before conditioning5.06.17.8-1.82.3-2.52.2-2.62.72.5-2.12.52.5-2.5-2.82.6
Saline control response0.81.01.5-0.91.0-0.90.9-0.91.21.1-0.41.01.2-1.2-1.21.0
Condit. Reinf. active minus inactive responses2.83.45.9-1.31.0-2.00.5-2.41.71.8-1.81.92.3-2.3-2.11.9
Condit. Reinf. active-inactive response ratio0.20.21.20.3-0.70.1-1.1-0.2-0.4-0.40.3-0.20.2-0.20.1-0.2
Condit. Reinf. active responses7.610.515.6-2.32.4-3.41.7-3.93.23.3-3.23.33.7-3.7-3.63.4
Condit. Reinf. inactive responses8.810.913.5-2.62.8-3.42.5-3.63.43.6-3.43.33.5-3.5-3.73.5
Condit. Reinf. lever presses1.82.53.7-1.61.1-1.50.7-1.71.61.9-1.51.61.7-1.7-1.91.6
Condit. Reinf. lever reinforcers received6.99.714.9-2.12.2-3.31.6-3.93.13.1-3.13.13.7-3.7-3.53.3
Pavlov. Cond. lever latency1.01.42.11.1-0.71.2-0.21.5-1.0-1.31.1-1.2-1.41.41.3-1.2
Pavlov. Cond. magazine entry latency0.10.10.3-0.3-0.1-0.2-0.3-0.40.10.2-0.60.20.3-0.3-0.30.2
Pavlov. Cond. change in total contacts1.72.43.5-1.31.1-1.70.8-1.71.51.2-1.81.51.9-1.9-1.71.6
Pavlov. Cond. index score0.60.81.5-0.80.3-0.90.1-1.00.70.7-1.20.81.1-1.1-1.00.9
Pavlov. Cond. latency score0.60.71.3-0.90.3-0.90.1-0.90.70.6-1.10.71.0-1.0-1.10.9
Pavlov. Cond. lever contacts0.91.32.5-0.80.5-1.10.1-1.61.01.5-1.21.11.3-1.3-1.31.1
Pavlov. Cond. magazine entry number1.01.32.20.7-0.71.2-0.61.4-1.1-0.91.5-1.0-1.31.31.3-1.2
Pavlov. Cond. intertrial magazine entries0.10.10.5-0.70.20.10.20.6-0.10.20.20.1-0.10.10.1-0.1
Pavlov. Cond. lever-magazine prob. diff.0.60.81.6-0.80.4-0.90.1-1.10.80.7-1.30.81.1-1.1-1.10.9
Pavlov. Cond. response bias1.82.54.1-1.11.0-1.70.6-2.01.51.9-1.81.61.8-1.8-1.81.6
Conditioned reinforcement - actives0.10.10.80.4-0.6-0.0-0.9-0.5-0.3-0.30.2-0.1-0.00.00.1-0.1
Conditioned reinforcement - inactives0.10.10.5-0.70.2-0.10.1-0.30.20.4-0.30.40.2-0.2-0.20.2
Conditioned locomotion0.10.10.3-0.3-0.2-0.2-0.4-0.50.20.50.00.20.2-0.2-0.40.3
Intermittent access intake day 1-15 change0.30.30.50.3-0.40.6-0.10.7-0.3-0.40.5-0.6-0.70.70.4-0.5
Intermittent access intake escalation0.10.10.2-0.1-0.20.40.10.5-0.1-0.10.2-0.3-0.50.50.2-0.3
Intermittent access intake escalation 20.20.20.60.1-0.00.40.20.8-0.2-0.30.5-0.4-0.70.70.3-0.4
Intermitt. access day 1 inactive lever presses0.10.10.5-0.7-0.20.3-0.20.40.00.2-0.1-0.20.0-0.0-0.3-0.1
Intermitt. access day 15 inactive lever presses0.10.10.30.3-0.40.4-0.5-0.0-0.30.40.5-0.2-0.40.40.2-0.3
Intermitt. access escalation Index1.21.11.60.7-1.11.3-1.01.3-1.0-1.00.9-1.2-1.01.00.8-1.1
Intermittent access day 1 total infusions0.30.31.60.3-0.4-0.4-0.8-1.30.20.5-0.40.30.6-0.6-0.60.4
Intermittent access day 15 total infusions0.20.21.10.3-0.5-0.1-0.7-1.00.10.6-0.30.10.3-0.3-0.30.1
Intermittent access terminal intake (last 3 days)0.10.10.80.4-0.2-0.2-0.4-0.90.20.4-0.10.20.2-0.2-0.30.2
Intermittent access total infusions0.20.31.50.5-0.90.1-1.2-0.7-0.30.00.1-0.20.1-0.10.0-0.2
Intermittent access day 1 locomotion0.30.31.60.6-0.90.1-1.3-0.8-0.30.00.1-0.20.1-0.1-0.0-0.2
Intermittent access day 15 total locomotion2.62.84.21.3-2.11.9-2.01.3-1.6-1.21.8-1.8-1.71.71.4-1.7
Intermittent access total locomotion1.41.63.71.3-1.81.2-1.90.4-1.2-1.11.3-1.3-1.11.10.9-1.2
Intermittent access standard deviation0.10.10.40.0-0.40.1-0.30.2-0.1-0.7-0.2-0.3-0.10.1-0.1-0.1
Cocaine induced anxiety0.20.20.5-0.2-0.60.4-0.60.7-0.5-0.60.4-0.5-0.50.50.2-0.4
Post-drug Anxiety0.50.63.2-1.80.7-0.40.90.70.70.3-0.00.40.2-0.2-0.90.6
Baseline Anxiety0.80.82.2-1.11.2-0.71.5-0.01.10.9-0.50.80.6-0.6-0.90.8
Lifetime Intake0.40.52.41.0-1.10.2-1.5-1.0-0.5-0.10.1-0.40.1-0.10.2-0.3
Incentive Sensitization - Responses0.20.20.5-0.1-0.60.4-0.70.4-0.4-0.20.4-0.4-0.40.40.2-0.4
Incentive Sensitization - Breakpoint0.20.20.6-0.2-0.60.4-0.80.4-0.5-0.20.4-0.4-0.40.40.3-0.4
Progressive ratio test 1 active lever presses0.40.41.90.7-1.10.4-1.4-0.4-0.6-0.30.2-0.4-0.10.10.3-0.5
Progressive ratio test 1 breakpoint0.40.42.00.8-1.10.4-1.4-0.4-0.6-0.40.2-0.4-0.10.10.4-0.5
Progressive ratio test 1 inactive lever presses0.30.31.30.3-0.5-0.2-0.8-1.10.00.4-0.50.20.6-0.6-0.30.2
Progressive ratio test 2 active lever presses0.70.83.90.8-1.50.7-2.0-0.3-0.9-0.30.5-0.7-0.30.30.6-0.7
Progressive ratio test 2 breakpoint0.80.94.00.7-1.60.8-2.00.1-1.1-0.60.7-0.9-0.50.50.7-0.9
Progressive ratio test 2 inactive lever presses0.40.52.60.5-1.30.6-1.6-0.2-0.6-0.40.6-0.6-0.30.30.1-0.5
Total sessions with >9 infusions1.21.32.71.1-1.51.1-1.70.4-1.3-1.40.9-1.2-0.80.81.1-1.1
Short access day 1 total inactive lever presses0.40.41.3-0.7-0.6-0.4-1.1-1.00.10.6-0.70.30.6-0.6-0.70.4
Short access day 10 total inactive lever presses0.40.41.3-1.20.6-0.30.7-0.00.61.1-0.30.60.1-0.1-0.70.5
Short access day 1 total infusions1.21.24.82.2-1.50.1-2.1-1.6-0.8-0.7-0.2-0.50.4-0.40.6-0.4
Short access day 10 total infusions0.10.10.3-0.2-0.3-0.0-0.6-0.4-0.00.0-0.20.10.2-0.2-0.10.0
Short access total infusions0.50.52.31.2-0.7-0.3-1.2-1.5-0.2-0.1-0.30.00.6-0.60.00.1
Short access day 1 locomotion2.22.45.81.7-2.11.3-2.40.2-1.8-1.41.3-1.4-1.11.11.6-1.5
Short access day 10 total locomotion1.92.12.90.9-1.31.6-1.01.6-1.3-1.71.4-1.6-1.61.61.3-1.5
Short access total locomotion1.11.11.91.2-1.31.0-1.40.4-1.0-1.20.9-1.1-0.80.81.0-1.0
Compulsive drug intake0.60.61.61.3-0.50.6-0.50.5-0.9-1.00.7-0.7-0.60.61.2-0.8
One hour access (0.3 mA shock)0.50.61.61.2-1.00.4-1.3-0.6-0.7-0.60.6-0.5-0.40.40.7-0.6
One hour access (shock baseline)0.10.10.60.0-0.6-0.0-0.8-0.7-0.00.1-0.1-0.10.1-0.1-0.30.0
Number of responses in last shaping day0.70.72.60.3-0.1-0.5-0.5-1.60.41.3-0.80.71.1-1.1-0.60.5
Context. condit. distance diff. score0.10.10.30.60.1-0.00.0-0.4-0.10.5-0.20.1-0.00.00.3-0.0
Locomotion velocity, session 10.80.81.9-0.1-1.31.0-1.41.0-0.9-0.90.5-1.0-0.80.80.4-0.8
Locomotion distance, session 10.00.00.20.3-0.40.2-0.4-0.0-0.20.1-0.1-0.2-0.10.10.1-0.2
Locomotion velocity, session 20.70.81.10.8-0.91.0-0.70.9-0.7-1.00.9-1.0-1.01.00.7-0.9
Locomotion distance, session 20.40.60.9-0.50.6-0.70.5-0.90.80.9-0.90.80.7-0.7-0.90.7
Locomotion velocity, session 30.50.51.91.4-0.80.6-0.80.1-0.8-0.40.3-0.6-0.70.70.9-0.7
Locomotion distance, session 30.10.10.40.20.3-0.20.2-0.50.10.7-0.30.40.2-0.20.10.2
Stereotopy head waving bouts, day 32.12.63.7-1.41.5-1.71.3-1.51.61.4-1.91.61.7-1.7-1.71.7
Stereotopy head waving duration, day 30.20.20.50.20.2-0.60.1-0.70.3-0.2-0.70.20.6-0.6-0.30.4
Locomotion velocity, session 70.30.31.0-0.20.00.50.21.0-0.4-0.30.7-0.3-0.70.70.5-0.5
Locomotion distance, session 70.40.51.3-1.01.1-0.51.10.00.60.6-0.40.80.2-0.2-0.40.5
Stereotopy head waving bouts, day 70.30.41.30.4-0.60.5-0.50.6-0.6-1.10.6-0.8-0.40.40.5-0.5
Stereotopy head waving duration, day 70.10.10.50.5-0.40.2-0.30.1-0.2-0.70.3-0.5-0.00.00.2-0.2
Locomotion velocity, session 80.50.63.41.8-0.90.3-0.9-0.5-0.6-0.60.2-0.6-0.30.30.6-0.5
Locomotion distance, session 80.10.10.60.8-0.2-0.1-0.3-0.7-0.10.5-0.40.10.1-0.10.10.0
Degree of sensitization distance0.20.20.7-0.40.30.20.50.8-0.0-0.50.5-0.2-0.40.40.2-0.2
Degree of sensitization stereotypy0.20.20.70.3-0.50.3-0.30.4-0.3-0.90.6-0.6-0.10.10.2-0.2
Condit. Reinf. active minus inactive responses2.12.44.8-1.51.2-1.51.0-1.51.41.5-2.21.51.7-1.7-1.61.6
Condit. Reinf. active-inactive response ratio1.41.52.2-0.91.4-1.31.3-1.21.21.1-1.51.31.3-1.3-1.11.3
Condit. Reinf. active responses1.61.93.8-1.50.6-1.20.3-1.41.21.8-1.91.41.5-1.5-1.71.3
Condit. Reinf. inactive responses0.80.92.5-1.30.1-0.6-0.1-0.80.81.6-1.00.90.9-0.9-1.30.8
Incentive salience index mean1.72.13.7-1.50.9-1.40.7-1.41.31.3-1.91.41.7-1.7-1.71.5
Condit. Reinf. lever presses1.11.52.3-1.30.8-1.20.6-1.21.21.2-1.21.21.5-1.5-1.41.3
Time in familiar zone, hab. session 10.30.31.1-0.5-0.10.60.11.1-0.3-0.30.4-0.3-0.70.70.3-0.4
Time in novel zone, hab. session 11.11.12.1-0.11.1-1.31.0-1.51.00.9-0.91.11.2-1.2-0.81.0
Total zone transitions, hab. session 12.33.24.80.5-2.01.9-1.92.2-1.9-1.81.4-1.9-1.81.81.5-1.8
Total locomotion distance, hab. session 10.20.31.2-0.6-0.90.3-1.10.5-0.5-0.3-0.3-0.40.1-0.1-0.0-0.3
Locomotion velocity, hab. session 10.30.42.1-0.3-1.20.4-1.50.3-0.6-0.3-0.3-0.50.1-0.10.0-0.4
Time in familiar zone, hab. session 23.33.45.7-1.32.0-1.81.9-1.91.82.4-1.62.11.7-1.7-1.61.9
Time in novel zone, hab. session 22.82.84.91.3-1.91.6-1.91.6-1.7-2.21.4-1.9-1.41.41.5-1.7
Total zone transitions, hab. session 20.20.20.50.7-0.60.5-0.60.2-0.5-0.20.4-0.4-0.40.40.4-0.5
Total locomotion distance, hab. session 20.20.30.90.1-0.0-0.4-0.3-0.80.31.0-0.70.50.5-0.5-0.40.4
Locomotion velocity, hab. session 20.10.10.50.3-0.4-0.0-0.7-0.5-0.10.6-0.40.10.2-0.2-0.10.0
Novel to familiar place preference ratio1.31.43.21.4-0.50.9-0.51.0-1.3-1.81.4-1.1-0.90.91.7-1.2
Novelty place preference1.61.74.01.5-0.71.1-0.61.1-1.4-2.01.6-1.2-1.01.01.8-1.3
Time in novel zone, NPP test1.41.53.41.5-0.51.0-0.51.0-1.3-1.81.6-1.1-0.90.91.7-1.2
Total zone transitions, NPP test0.10.10.5-0.3-0.60.3-0.70.3-0.10.2-0.1-0.3-0.20.2-0.3-0.2
Total locomotion distance, NPP test0.40.51.2-1.1-0.2-0.4-0.5-0.60.41.0-1.00.50.7-0.7-0.90.5
Locomotion velocity, NPP test0.50.71.4-1.2-0.1-0.5-0.4-0.70.51.2-1.20.60.8-0.8-1.00.7
Pavlov. Cond. lever latency0.10.10.30.60.5-0.40.4-0.50.10.3-0.10.40.2-0.20.30.1
Pavlov. Cond. magazine entry latency0.40.51.2-1.00.9-0.61.1-0.10.80.2-0.40.60.6-0.6-0.80.8
Pavlov. Cond. change in total contacts0.20.21.4-1.20.5-0.20.60.40.4-0.1-0.30.20.3-0.3-0.50.4
Pavlov. Cond. index score0.10.10.7-0.9-0.00.00.10.40.2-0.3-0.1-0.00.1-0.1-0.40.2
Pavlov. Cond. latency score0.10.10.3-0.6-0.30.2-0.20.5-0.0-0.60.1-0.2-0.00.0-0.2-0.0
Pavlov. Cond. lever contacts0.20.21.0-1.0-0.1-0.1-0.10.10.4-0.1-0.30.10.4-0.4-0.80.4
Pavlov. Cond. magazine entry number0.30.31.01.0-0.60.4-0.8-0.1-0.6-0.10.5-0.5-0.40.40.6-0.6
Pavlov. Cond. intertrial magazine entries0.20.21.1-1.1-0.1-0.1-0.30.10.20.7-0.30.20.2-0.2-0.60.2
Pavlov. Cond. lever-magazine prob. diff.0.10.20.9-1.00.2-0.20.30.20.4-0.1-0.30.20.3-0.3-0.60.4
Pavlov. Cond. response bias0.20.31.3-1.20.4-0.30.50.20.50.2-0.30.40.4-0.4-0.70.5
Bone: apparent density0.40.74.9-2.20.7-0.40.80.30.61.1-0.30.70.3-0.3-0.80.6
Bone surface0.71.35.2-2.31.0-0.71.0-0.11.01.7-0.81.00.6-0.6-1.20.9
Bone volume0.50.94.8-2.20.7-0.40.80.20.81.5-0.50.80.3-0.3-1.00.7
Bone: connectivity density1.52.47.1-2.71.3-1.31.3-0.71.51.8-1.51.51.3-1.3-1.71.5
Bone: cortical apparent density1.11.52.3-1.11.0-1.20.9-1.21.30.8-1.31.11.5-1.5-1.41.3
Bone: cortical area2.84.36.5-2.22.2-1.92.1-1.62.22.6-1.72.21.8-1.8-2.22.1
Bone: cortical porosity0.91.01.51.2-1.11.1-1.20.8-1.1-1.00.8-1.1-0.90.90.9-1.0
Bone: cortical porosity0.70.81.41.2-1.00.9-1.10.5-0.9-0.90.6-0.9-0.80.80.8-0.9
Bone: cortical thickness2.54.16.1-2.22.4-1.92.5-1.32.12.3-1.62.11.7-1.7-2.02.0
Bone: cortical thickness0.40.40.9-0.80.9-0.60.9-0.30.71.00.10.80.4-0.4-0.50.6
Bone: cortical tissue density0.91.22.0-1.00.8-1.10.8-1.01.10.7-1.21.01.4-1.4-1.31.2
Bone: elastic displacement1.41.63.61.9-1.31.1-1.30.5-1.3-1.31.2-1.3-1.01.01.4-1.3
Bone: elastic work1.82.33.51.9-1.61.5-1.50.9-1.5-1.51.9-1.6-1.31.31.6-1.5
Bone: endosteal estimation0.40.81.9-0.80.6-0.80.5-1.10.91.4-0.90.90.7-0.7-1.10.9
Bone: endosteal perimeter0.10.20.50.20.3-0.30.1-0.70.40.5-0.50.40.3-0.3-0.40.4
Bone: final force1.22.02.6-1.61.4-1.41.4-1.11.51.6-1.31.51.3-1.3-1.51.4
Bone: final moment0.61.11.5-1.20.9-1.00.9-0.91.11.2-0.91.10.9-0.9-1.21.0
Bone: marrow area0.40.81.9-0.70.7-0.80.5-1.10.91.4-0.90.90.7-0.7-1.10.9
Bone: maximum diameter2.34.26.8-1.81.8-1.91.5-2.12.12.6-2.22.11.9-1.9-2.32.1
Bone: maximum force0.40.71.6-1.31.0-0.71.0-0.40.91.0-0.40.90.7-0.7-0.90.8
Bone: maximum moment0.10.20.8-0.90.5-0.30.5-0.10.50.60.00.50.3-0.3-0.60.4
Bone: minimum diameter0.71.32.5-1.51.1-1.01.0-0.91.21.6-0.41.31.0-1.0-1.41.2
Bone: periosteal estimation1.32.74.9-1.61.6-1.51.6-1.51.72.2-1.41.71.4-1.4-1.81.6
Bone: periosteal perimeter0.71.21.7-0.51.0-1.00.9-1.31.21.3-1.01.11.0-1.0-1.21.1
Bone: post-yield work0.20.20.7-0.80.4-0.30.4-0.20.50.40.10.40.5-0.5-0.60.5
Bone: stiffness0.81.32.2-1.51.3-1.01.3-0.61.21.3-1.01.20.9-0.9-1.31.1
Bone: tissue strength0.00.00.10.1-0.00.1-0.10.1-0.2-0.20.2-0.1-0.20.20.2-0.2
Bone: trabecular number0.30.43.3-1.80.4-0.10.50.50.41.0-0.10.40.1-0.1-0.60.4
Bone: trabecular spacing0.10.10.60.80.3-0.30.4-0.50.30.2-0.30.20.2-0.2-0.10.2
Bone: trabecular thickness0.40.42.7-1.60.5-0.30.60.10.60.8-0.20.50.2-0.2-0.70.5
Bone: trabecular tissue density0.10.10.30.50.20.20.60.4-0.1-0.5-0.0-0.2-0.40.40.4-0.3
Breakpoint value in progressive ratio session0.00.00.10.2-0.20.1-0.30.2-0.2-0.3-0.1-0.2-0.10.10.1-0.1
Distance traveled before self-admin0.10.10.4-0.40.5-0.60.4-0.20.1-0.2-0.20.40.4-0.40.00.3
Distance traveled after self-admin0.60.72.80.30.0-0.9-0.7-1.70.30.6-0.40.81.1-1.1-0.50.7
Delta time in closed arm before/after self-admin3.23.15.12.3-2.01.6-1.91.1-1.7-2.11.4-2.0-1.51.51.6-1.7
Delta time in open arm before/after self-admin1.71.65.8-2.41.7-0.72.10.61.31.1-0.81.10.6-0.6-1.21.0
Diff in mean of infusions in LGA sessions1.31.52.81.1-1.41.3-1.70.7-1.4-0.81.4-1.1-1.11.11.3-1.3
Extinction: sum of active levers before priming0.10.10.4-0.4-0.30.3-0.40.7-0.4-0.40.3-0.3-0.20.20.2-0.3
Active lever presses in extinction session 61.91.82.7-1.51.3-1.31.1-1.21.41.7-1.31.51.3-1.3-1.51.4
Delta distance traveled before/after self-admin1.61.77.50.6-0.2-1.0-1.0-2.70.62.0-1.21.11.3-1.3-0.90.9
Delta ambulatory time before/after self-admin1.41.66.10.20.0-1.1-0.8-2.50.61.9-1.21.21.3-1.3-0.91.0
Time in closed arm before self-admin0.60.72.2-0.4-0.31.0-0.01.5-0.7-0.31.0-0.7-1.11.10.8-0.9
Time in closed arm after self-admin1.21.31.80.9-1.01.2-0.91.2-1.1-1.01.3-1.2-1.21.21.1-1.2
Time in open arm before self-admin0.50.52.61.6-0.7-0.2-1.1-1.4-0.3-0.1-0.3-0.10.6-0.60.2-0.0
Time in open arm after self-admin0.50.52.2-1.50.9-0.21.10.50.80.7-0.20.60.2-0.2-0.90.6
Sum of active levers in priming session hrs 5-62.42.44.7-0.31.0-1.80.4-2.21.11.2-2.01.72.1-2.1-1.11.5
Time to tail flick, vehicle, before self-admin3.33.45.2-1.52.3-2.02.3-1.61.91.4-1.82.01.7-1.7-1.61.9
Time to tail flick, vehicle, after self-admin0.20.20.5-0.70.5-0.50.5-0.20.4-0.1-0.40.40.4-0.4-0.40.4
Time to tail flick, test, before self-admin0.10.10.30.3-0.30.3-0.40.4-0.3-0.50.5-0.3-0.20.20.2-0.3
Time to tail flick, test, after self-admin1.01.12.80.20.6-1.00.3-1.70.90.9-0.90.91.5-1.5-0.91.0
Delta time to tail flick, vehicle, before/after SA0.80.81.20.8-1.10.9-1.00.7-0.8-0.61.0-0.9-0.90.90.7-0.9
Delta time to tail flick, test, before/after SA0.30.30.90.50.3-0.60.2-0.90.40.1-0.50.20.7-0.7-0.30.5
Ambulatory time before self-admin0.10.10.3-0.40.5-0.40.50.20.1-0.3-0.10.20.2-0.20.10.2
Ambulatory time after self-admin0.50.62.10.10.2-0.9-0.4-1.40.30.9-0.50.80.9-0.9-0.40.7
Total heroin consumption0.20.21.11.0-0.5-0.1-0.5-0.4-0.5-0.6-0.5-0.3-0.20.20.6-0.2
Area under the delay curve4.04.36.2-1.22.1-2.31.9-2.51.92.1-2.32.32.2-2.2-1.62.1
Delay disc. indifference point, 0s delay1.51.62.2-0.61.5-1.31.3-1.41.21.4-1.31.51.3-1.3-0.91.3
Delay disc. indifference point, 16s delay5.25.26.2-1.62.4-2.52.2-2.42.32.3-2.42.52.3-2.3-2.02.3
Delay disc. indifference point, 2s delay0.60.61.0-0.41.0-0.90.9-0.80.70.6-1.00.90.8-0.8-0.50.8
Delay disc. indifference point, 24s delay0.60.61.4-0.20.8-1.00.6-1.20.50.9-0.90.90.7-0.7-0.30.7
Delay disc. indifference point, 4s delay0.70.81.4-1.20.9-1.00.7-0.80.70.6-0.91.00.9-0.9-0.70.9
Delay disc. indifference point, 8s delay5.25.48.9-0.92.3-2.51.9-3.02.12.6-2.52.62.5-2.5-1.82.3
Delay discount exponential model param4.24.45.91.4-2.22.3-1.92.4-1.9-2.12.3-2.3-2.22.21.7-2.1
Delay discount hyperbolic model param3.74.05.01.4-2.02.2-1.82.2-1.9-2.02.2-2.2-2.02.01.6-2.0
Fecal boli incidents, locomotor time 10.20.21.21.1-0.60.2-0.8-0.5-0.4-0.40.1-0.30.0-0.00.4-0.3
Change in fecal boli incidents, locomotor task0.20.20.70.5-0.70.2-0.8-0.4-0.4-0.2-0.2-0.4-0.10.10.2-0.2
Time >=10cm from walls, locomotor time 10.60.61.20.9-1.00.9-1.10.2-1.0-0.30.7-0.8-0.30.30.9-0.9
Bouts of movement, locomotor time 11.11.33.3-0.30.8-1.00.6-1.60.91.8-0.91.21.5-1.5-0.81.0
Total resting periods, locomotor time 11.01.12.70.00.6-0.80.4-1.60.81.6-0.91.11.4-1.4-0.70.9
Rest time, locomotor task time 10.10.10.50.7-0.40.6-0.3-0.0-0.40.30.3-0.3-0.20.20.5-0.4
Distance moved, locomotor task time 10.50.52.6-1.60.8-0.31.11.10.6-0.3-0.00.2-0.20.2-0.70.4
Vertical activity count, locomotor time 10.80.83.8-1.50.60.30.91.90.0-1.10.6-0.3-0.80.8-0.0-0.1
Time >=10cm from walls, locomotor time 24.64.97.91.1-1.82.3-1.52.8-2.1-2.62.6-2.3-2.42.42.0-2.2
Bouts of movement, locomotor time 20.30.30.6-0.60.5-0.60.5-0.70.60.8-0.50.60.3-0.3-0.50.6
Total resting periods, locomotor time 20.10.10.3-0.40.3-0.30.3-0.30.30.5-0.20.30.1-0.1-0.20.3
Rest time, locomotor task time 21.31.52.91.5-1.11.3-1.00.9-1.4-0.91.0-1.2-1.21.21.7-1.4
Distance moved, locomotor task time 20.80.93.2-1.81.3-0.51.61.01.00.1-0.10.6-0.10.1-1.00.7
Vertical activity count, locomotor time 21.01.14.9-2.21.4-0.61.60.91.00.1-0.20.60.2-0.2-1.10.8
Weight adjusted by age1.41.52.60.9-0.91.3-0.61.4-1.2-1.51.6-1.3-1.21.21.3-1.2
Seeking ratio, delayed vs. immediate footshock0.60.61.6-1.00.5-0.80.3-0.50.90.6-0.40.61.0-1.0-1.30.9
Locomotion in novel chamber0.30.41.71.3-0.7-0.0-1.0-1.0-0.5-0.0-0.3-0.20.2-0.20.4-0.2
Locomotion in novel chamber post-restriction0.10.10.70.10.40.10.80.40.2-0.10.2-0.0-0.50.50.0-0.0
Progressive ratio0.30.31.91.4-0.3-0.3-0.6-0.9-0.3-0.3-0.3-0.00.3-0.30.4-0.0
Food seeking constrained by brief footshock0.20.30.4-0.40.6-0.60.6-0.40.50.3-0.60.40.5-0.5-0.40.5
Seeking ratio, punishment vs. effort0.30.31.4-1.20.7-0.01.00.50.50.5-0.00.3-0.00.0-0.50.3
Run reversals in cocaine runway, females0.60.60.8-0.20.9-0.90.9-0.90.70.7-0.80.80.9-0.9-0.60.9
Run reversals in cocaine runway, males0.10.10.20.30.2-0.30.4-0.20.2-0.3-0.40.00.3-0.3-0.10.3
Latency to leave start box in cocaine runway1.61.82.5-0.91.6-1.31.5-1.41.41.6-1.21.61.1-1.1-1.21.4
Latency to leave start box in cocaine runway, F1.31.42.7-1.11.5-1.01.6-0.61.41.5-0.91.30.6-0.6-1.21.2
Latency to leave start box in cocaine runway, M0.20.20.80.5-0.1-0.2-0.4-0.9-0.3-0.3-0.10.10.4-0.40.40.1
Cd content in liver0.10.10.20.3-0.3-0.0-0.4-0.4-0.00.1-0.4-0.00.2-0.2-0.10.0
Co content in liver0.40.51.3-0.6-0.90.7-0.81.2-0.6-0.70.1-0.7-0.70.70.2-0.6
Cu content in liver4.14.96.2-1.72.0-2.41.8-2.52.32.1-2.12.32.4-2.4-2.32.4
Fe content in liver1.82.25.2-2.31.8-1.41.7-0.51.41.4-1.01.61.2-1.2-1.41.4
K content in liver0.30.30.8-0.5-0.0-0.5-0.0-0.50.50.4-0.50.30.6-0.6-0.90.6
Mg content in liver1.31.42.6-0.60.5-1.20.4-1.61.11.4-1.31.11.3-1.3-1.41.2
Mn content in liver0.50.60.90.6-0.90.9-0.80.7-0.7-0.30.9-0.8-0.80.80.6-0.8
Na content in liver0.10.10.5-0.70.0-0.2-0.10.00.1-0.1-0.10.10.4-0.4-0.30.2
Rb content in liver1.51.93.8-1.40.9-1.31.1-1.21.71.9-1.21.31.1-1.1-1.91.5
Se content in liver0.50.62.1-1.50.8-0.61.00.10.80.7-0.60.60.5-0.5-0.90.7
Sr content in liver0.90.91.4-0.70.9-1.10.7-1.00.80.4-1.20.91.1-1.1-0.81.0
Zn content in liver2.73.04.6-1.61.5-1.81.4-1.71.61.7-2.11.71.9-1.9-1.71.8