| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | gene expression | ENSRNOG00000003566 | 0.0230 | 0.0170 | 9.0e-03 | 0.004 | 0.005 | 0.002 | 0.004 | 1.1e-01 | 7.8e-02 | 2.0e-01 | 1.0e-01 |
| 2 | Brain | gene expression | ENSRNOG00000003566 | 0.0890 | 0.0550 | 2.0e-03 | 0.020 | 0.030 | 0.006 | 0.014 | 4.9e-03 | 8.7e-04 | 7.5e-02 | 1.8e-02 |
| 3 | Liver | gene expression | ENSRNOG00000003566 | 0.2700 | 0.1100 | 0.0e+00 | 0.145 | 0.212 | 0.208 | 0.209 | 7.4e-16 | 4.1e-23 | 1.1e-22 | 9.3e-23 |
| 4 | Liver | mRNA stability | ENSRNOG00000003566 | 0.2659 | 0.1024 | 0.0e+00 | 0.261 | 0.261 | 0.265 | 0.265 | 7.1e-29 | 6.5e-29 | 2.3e-29 | 2.6e-29 |
| 5 | NAcc | gene expression | ENSRNOG00000003566 | 0.2100 | 0.0830 | 1.5e-15 | 0.186 | 0.206 | 0.202 | 0.194 | 8.4e-14 | 2.8e-15 | 5.4e-15 | 2.1e-14 |
| 6 | PL | gene expression | ENSRNOG00000003566 | 0.0657 | 0.0393 | 2.2e-04 | 0.058 | 0.047 | 0.022 | 0.053 | 3.0e-05 | 1.7e-04 | 8.5e-03 | 6.7e-05 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 |
|---|---|---|---|---|---|---|---|---|---|
| Bone: endosteal perimeter | 10.5 | 21.5 | 39.6 | 4.6 | 5.5 | 3.1 | -0.9 | 6.3 | 5.3 |
| Bone: endosteal estimation | 10.4 | 22.5 | 42.6 | 4.9 | 5.2 | 3.1 | -1.0 | 6.5 | 5.5 |
| Bone: marrow area | 10.1 | 21.6 | 41.1 | 4.8 | 5.1 | 3.0 | -1.1 | 6.4 | 5.4 |
| Bone: minimum diameter | 9.2 | 17.0 | 28.5 | 4.7 | 4.2 | 3.4 | 0.3 | 5.3 | 4.7 |
| Intermittent access total locomotion | 8.0 | 9.0 | 13.3 | 3.7 | 2.4 | 3.2 | 1.7 | 3.3 | 3.2 |
| Short access day 10 total locomotion | 7.3 | 7.9 | 11.1 | 3.3 | 2.2 | 3.1 | 1.9 | 2.9 | 3.1 |
| Bone: periosteal estimation | 7.1 | 14.5 | 26.3 | 4.4 | 3.8 | 2.9 | -0.3 | 5.1 | 4.4 |
| Delay discounting total patch changes 6 sec | 6.5 | 10.0 | 15.2 | 3.9 | 2.2 | 3.5 | 1.8 | 3.4 | 3.6 |
| Stereotopy head waving bouts, day 3 | 5.8 | 6.9 | 10.2 | -2.7 | -2.5 | -2.7 | -1.7 | -2.8 | -3.2 |
| Bone: periosteal perimeter | 5.7 | 9.4 | 15.2 | 3.0 | 3.7 | 2.4 | 0.2 | 3.9 | 3.6 |
| Stereotopy head waving duration, day 7 | 5.2 | 6.3 | 8.1 | -2.8 | -2.5 | -2.5 | -1.2 | -2.8 | -2.9 |
| Intermittent access standard deviation | 5.0 | 5.3 | 7.8 | 2.0 | 2.7 | 2.1 | 1.4 | 2.4 | 2.8 |
| Body weight | 4.7 | 19.7 | 33.5 | 5.1 | 1.7 | 5.8 | 5.6 | 2.9 | 4.0 |
| Intermittent access day 15 total locomotion | 4.7 | 5.0 | 7.2 | 2.6 | 2.1 | 2.1 | 0.9 | 2.7 | 2.5 |
| Short access total locomotion | 4.5 | 4.6 | 7.9 | 2.8 | 0.8 | 2.7 | 2.1 | 1.8 | 2.1 |
| Indifference point 0 sec | 4.4 | 7.1 | 13.7 | 3.7 | 1.4 | 3.0 | 1.5 | 2.9 | 2.7 |
| Intermittent access intake escalation 2 | 4.2 | 4.2 | 6.1 | 2.0 | 2.3 | 1.8 | 0.7 | 2.5 | 2.5 |
| Epididymis fat weight | 4.1 | 9.5 | 20.9 | 3.0 | 1.3 | 4.1 | 4.6 | 1.4 | 2.6 |
| Delay discounting total patch changes 0 sec | 4.0 | 6.4 | 12.8 | 3.6 | 1.2 | 2.9 | 1.4 | 2.8 | 2.5 |
| Delay discounting total patch changes 12 sec | 4.0 | 5.3 | 8.8 | 3.0 | 1.7 | 2.3 | 0.8 | 2.7 | 2.6 |
| Retroperitoneal fat weight | 3.9 | 12.9 | 22.7 | 4.1 | 1.0 | 4.8 | 4.7 | 2.1 | 3.2 |
| Delay discounting total patch changes 24 sec | 3.9 | 5.0 | 7.5 | 2.7 | 1.7 | 2.5 | 1.3 | 2.4 | 2.4 |
| Intermittent access day 1 locomotion | 3.7 | 3.8 | 4.8 | 2.2 | 1.7 | 2.1 | 1.4 | 2.0 | 2.2 |
| Intermittent access terminal intake (last 3 days) | 3.6 | 3.9 | 6.2 | 2.3 | 1.9 | 1.8 | 0.5 | 2.5 | 2.2 |
| Rest time, locomotor task time 2 | 3.5 | 4.0 | 9.0 | -3.0 | 0.4 | -2.4 | -2.1 | -1.5 | -1.5 |
| Mg content in liver | 3.5 | 3.6 | 6.5 | -1.7 | -1.3 | -2.3 | -2.6 | -1.2 | -2.0 |
| Intermittent access day 15 total infusions | 3.4 | 3.8 | 5.4 | 2.0 | 2.1 | 1.8 | 0.8 | 2.3 | 2.3 |
| Condit. Reinf. active minus inactive responses | 3.4 | 3.8 | 5.9 | 2.1 | 1.9 | 1.7 | 0.3 | 2.4 | 2.3 |
| Run reversals in cocaine runway, females | 3.4 | 3.3 | 13.9 | 0.9 | -0.2 | 2.1 | 3.7 | -0.5 | 0.8 |
| Intermittent access intake escalation | 3.3 | 3.3 | 5.5 | 1.4 | 2.3 | 1.5 | 0.7 | 2.0 | 2.3 |
| BMI with tail | 3.2 | 10.3 | 31.5 | 3.0 | -0.3 | 4.2 | 5.6 | 0.4 | 1.9 |
| Short access day 10 total infusions | 3.2 | 3.5 | 7.4 | 2.7 | 0.3 | 2.3 | 1.7 | 1.6 | 1.6 |
| Intermittent access intake day 1-15 change | 3.1 | 3.1 | 5.0 | 1.5 | 2.2 | 1.5 | 0.7 | 2.0 | 2.2 |
| Stereotopy head waving bouts, day 7 | 3.1 | 3.5 | 5.2 | -1.9 | -2.1 | -1.6 | -0.3 | -2.3 | -2.2 |
| Condit. Reinf. active-inactive response ratio | 2.9 | 3.0 | 5.7 | 1.7 | 2.0 | 1.0 | -0.5 | 2.4 | 2.1 |
| Stereotopy head waving duration, day 3 | 2.9 | 3.6 | 5.2 | -2.1 | -1.5 | -2.0 | -1.3 | -2.0 | -2.3 |
| Novel to familiar place preference ratio | 2.9 | 3.1 | 4.6 | 1.7 | 2.1 | 1.5 | 0.3 | 2.1 | 2.1 |
| Pavlov. Cond. intertrial magazine entries | 2.9 | 3.5 | 4.8 | 1.9 | 2.0 | 1.8 | 0.7 | 2.1 | 2.2 |
| Mn content in liver | 2.9 | 3.4 | 6.2 | -1.5 | -1.2 | -2.3 | -2.5 | -1.0 | -2.0 |
| BMI without tail | 2.8 | 5.8 | 12.9 | 3.0 | -0.6 | 3.2 | 3.6 | 0.8 | 1.4 |
| Bone: maximum diameter | 2.8 | 5.2 | 10.3 | 2.2 | 2.7 | 1.1 | -1.1 | 3.2 | 2.5 |
| Bone: post-yield work | 2.8 | 3.9 | 6.0 | 1.9 | 2.2 | 1.7 | 0.5 | 2.3 | 2.4 |
| Heart weight | 2.7 | 3.8 | 5.6 | 1.5 | 2.4 | 2.1 | 1.5 | 1.8 | 2.2 |
| Condit. Reinf. lever reinforcers received | 2.7 | 3.7 | 7.1 | 2.4 | 1.5 | 1.5 | -0.2 | 2.7 | 2.2 |
| Bone: cortical porosity | 2.7 | 2.9 | 4.1 | 2.0 | 1.5 | 1.7 | 0.8 | 2.0 | 2.0 |
| Reaction time false alarm rate | 2.6 | 3.7 | 5.4 | 2.3 | 1.1 | 2.1 | 1.7 | 1.9 | 2.2 |
| Condit. Reinf. active minus inactive responses | 2.6 | 3.2 | 6.4 | 2.0 | 1.6 | 1.2 | -0.5 | 2.5 | 2.1 |
| Condit. Reinf. active responses | 2.6 | 3.5 | 7.0 | 2.4 | 1.5 | 1.4 | -0.3 | 2.6 | 2.1 |
| Progressive ratio test 1 inactive lever presses | 2.6 | 2.8 | 6.0 | 2.5 | 0.1 | 2.1 | 1.5 | 1.4 | 1.4 |
| Bone: cortical thickness | 2.6 | 4.2 | 8.9 | -0.7 | -3.0 | 0.2 | 2.3 | -2.7 | -1.8 |
| Vertical activity count, locomotor time 2 | 2.6 | 2.9 | 5.3 | 2.3 | -1.3 | 2.0 | 2.3 | 0.5 | 0.9 |
| Delay discounting total patch changes 18 sec | 2.5 | 3.3 | 5.1 | 2.3 | 0.8 | 2.2 | 1.8 | 1.6 | 1.8 |
| Condit. Reinf. active responses | 2.5 | 3.1 | 4.8 | 2.1 | 1.4 | 1.7 | 0.4 | 2.2 | 2.1 |
| Time in novel zone, hab. session 2 | 2.5 | 2.6 | 3.9 | -1.6 | -1.6 | -1.7 | -1.1 | -1.6 | -2.0 |
| Mean time between licks in bursts | 2.4 | 3.3 | 4.5 | 1.6 | 1.8 | 2.1 | 2.0 | 1.4 | 1.9 |
| Condit. Reinf. lever presses | 2.4 | 3.3 | 6.5 | 2.6 | 0.7 | 1.9 | 0.8 | 2.1 | 2.0 |
| Bone: cortical apparent density | 2.4 | 3.2 | 5.8 | -1.7 | -2.1 | -1.2 | 0.1 | -2.4 | -2.2 |
| Bone: cortical tissue density | 2.4 | 3.1 | 5.6 | -1.7 | -2.0 | -1.2 | 0.1 | -2.4 | -2.1 |
| Intermitt. access day 1 inactive lever presses | 2.3 | 2.5 | 3.7 | 1.9 | 0.9 | 1.8 | 1.3 | 1.6 | 1.8 |
| Time in familiar zone, hab. session 1 | 2.3 | 2.1 | 3.3 | 1.3 | 1.8 | 1.0 | -0.1 | 1.8 | 1.8 |
| Length with tail | 2.2 | 7.9 | 10.3 | 3.0 | 2.8 | 2.9 | 1.3 | 3.2 | 3.2 |
| Reaction time premature initiation rate | 2.2 | 2.9 | 4.2 | 1.8 | 1.3 | 2.1 | 1.7 | 1.4 | 1.9 |
| Bone: cortical thickness | 2.2 | 2.6 | 6.6 | -0.8 | -2.6 | -0.6 | 0.5 | -2.0 | -1.8 |
| Social responses | 2.1 | 2.7 | 5.5 | 2.3 | 0.2 | 2.0 | 1.4 | 1.5 | 1.6 |
| Progressive ratio test 1 breakpoint | 2.1 | 2.2 | 5.2 | 2.3 | -0.5 | 1.8 | 1.5 | 1.0 | 1.0 |
| Pavlov. Cond. change in total contacts | 2.1 | 2.2 | 3.6 | 1.9 | 0.4 | 1.8 | 1.6 | 1.2 | 1.5 |
| Bone: tissue strength | 2.1 | 2.1 | 2.8 | -1.7 | -1.2 | -1.5 | -0.7 | -1.6 | -1.6 |
| Delta time in open arm before/after self-admin | 2.1 | 2.0 | 2.7 | -1.5 | -1.2 | -1.5 | -1.0 | -1.4 | -1.7 |
| Time in open arm before self-admin | 2.1 | 2.3 | 4.8 | 0.7 | 2.2 | 1.6 | 1.3 | 1.1 | 1.7 |
| Novelty place preference | 2.0 | 2.1 | 3.0 | 1.4 | 1.7 | 1.2 | 0.3 | 1.7 | 1.7 |
| Latency to leave start box in cocaine runway | 2.0 | 2.2 | 5.2 | -1.0 | -2.3 | -0.7 | 0.8 | -1.9 | -1.6 |
| Reaction time num false alarms AUC | 1.9 | 2.7 | 4.2 | 2.0 | 1.1 | 1.7 | 1.1 | 1.8 | 1.8 |
| Intermittent access total infusions | 1.9 | 2.1 | 3.6 | 1.9 | 1.2 | 1.4 | 0.4 | 1.9 | 1.5 |
| Pavlov. Cond. latency score | 1.9 | 2.4 | 3.7 | 1.8 | 0.7 | 1.9 | 1.7 | 1.3 | 1.6 |
| Reaction time num false alarms | 1.8 | 2.5 | 3.5 | 1.9 | 1.0 | 1.7 | 1.4 | 1.6 | 1.7 |
| Saline control response | 1.8 | 2.3 | 7.0 | 1.6 | -0.8 | 1.9 | 2.6 | 0.1 | 0.5 |
| Progressive ratio test 1 active lever presses | 1.8 | 1.9 | 4.4 | 2.1 | -0.6 | 1.7 | 1.5 | 0.9 | 0.9 |
| Pavlov. Cond. lever contacts | 1.8 | 2.1 | 5.1 | 1.5 | 0.2 | 1.9 | 2.3 | 0.6 | 1.2 |
| Distance moved, locomotor task time 2 | 1.8 | 2.1 | 5.4 | 1.0 | -2.3 | 1.0 | 2.1 | -0.9 | -0.4 |
| Bone: cortical porosity | 1.7 | 1.8 | 3.3 | 1.7 | 1.0 | 1.1 | 0.1 | 1.8 | 1.6 |
| Rb content in liver | 1.7 | 2.2 | 4.1 | -1.6 | -0.5 | -1.9 | -2.0 | -0.8 | -1.4 |
| Conditioned reinforcement - actives | 1.6 | 1.6 | 3.2 | -0.8 | -1.0 | -1.5 | -1.8 | -0.6 | -1.3 |
| Short access day 10 total inactive lever presses | 1.6 | 1.8 | 2.7 | 1.2 | 1.6 | 1.3 | 0.6 | 1.4 | 1.6 |
| Degree of sensitization stereotypy | 1.6 | 1.8 | 3.1 | -1.2 | -1.8 | -0.8 | 0.4 | -1.7 | -1.5 |
| Time in novel zone, NPP test | 1.6 | 1.7 | 2.5 | 1.3 | 1.5 | 1.1 | 0.2 | 1.6 | 1.5 |
| Pavlov. Cond. magazine entry latency | 1.6 | 2.1 | 3.5 | 1.9 | 0.9 | 1.6 | 0.8 | 1.6 | 1.6 |
| Pavlov. Cond. index score | 1.6 | 2.1 | 3.4 | 1.8 | 0.6 | 1.7 | 1.3 | 1.3 | 1.5 |
| Bone: maximum force | 1.6 | 2.8 | 4.5 | 2.1 | 1.4 | 1.5 | 0.3 | 2.1 | 1.9 |
| Bone: maximum moment | 1.6 | 2.7 | 4.4 | 2.1 | 1.3 | 1.5 | 0.2 | 2.1 | 1.9 |
| Food consumed during 24 hour testing period | 1.5 | 1.8 | 3.8 | 1.3 | -1.8 | 1.3 | 1.9 | -0.4 | -0.3 |
| Locomotor activity | 1.5 | 2.5 | 4.7 | 2.2 | -0.4 | 2.0 | 2.0 | 0.9 | 1.0 |
| Intermitt. access day 15 inactive lever presses | 1.5 | 1.7 | 2.9 | 1.4 | 0.8 | 1.7 | 1.5 | 1.0 | 1.2 |
| One hour access (0.3 mA shock) | 1.5 | 1.7 | 3.5 | 1.4 | 1.3 | 0.8 | -0.5 | 1.9 | 1.4 |
| Se content in liver | 1.5 | 1.8 | 3.8 | -1.9 | -0.3 | -1.5 | -1.1 | -1.3 | -1.3 |
| Right kidney weight | 1.4 | 4.1 | 6.5 | 2.0 | 1.5 | 2.6 | 2.3 | 1.5 | 2.2 |
| Conditioned locomotion | 1.4 | 1.6 | 3.1 | 1.5 | 1.4 | 0.9 | -0.2 | 1.8 | 1.3 |
| Lifetime Intake | 1.4 | 1.6 | 3.2 | 1.8 | 0.8 | 1.3 | 0.4 | 1.5 | 1.3 |
| Incentive salience index mean | 1.4 | 1.7 | 2.6 | 1.6 | 1.0 | 1.3 | 0.5 | 1.6 | 1.6 |
| Time in novel zone, hab. session 1 | 1.4 | 1.4 | 2.7 | -0.8 | -1.6 | -0.7 | 0.2 | -1.4 | -1.5 |
| Total locomotion distance, NPP test | 1.4 | 1.9 | 7.4 | 0.1 | -2.7 | -0.3 | 0.3 | -1.3 | -1.5 |
| Pavlov. Cond. lever latency | 1.4 | 1.8 | 3.6 | -1.6 | -0.2 | -1.8 | -1.9 | -0.8 | -1.1 |
| Pavlov. Cond. lever-magazine prob. diff. | 1.4 | 1.7 | 2.8 | 1.7 | 0.5 | 1.6 | 1.3 | 1.2 | 1.3 |
| Time to tail flick, test, before self-admin | 1.4 | 1.4 | 3.3 | 0.7 | 1.8 | 0.5 | -0.5 | 1.5 | 1.3 |
| Delay disc. indifference point, 24s delay | 1.4 | 1.3 | 1.8 | 1.3 | 1.0 | 1.4 | 1.1 | 1.1 | 1.1 |
| Bouts of movement, locomotor time 2 | 1.4 | 1.5 | 6.0 | 0.6 | -0.5 | 1.5 | 2.5 | -0.5 | 0.3 |
| Baseline Anxiety | 1.3 | 1.4 | 2.3 | -1.4 | -1.0 | -1.0 | -0.2 | -1.5 | -1.3 |
| Locomotion velocity, session 3 | 1.3 | 1.5 | 3.0 | -1.2 | -1.5 | -0.6 | 0.7 | -1.7 | -1.3 |
| Time in familiar zone, hab. session 2 | 1.3 | 1.3 | 2.1 | 1.2 | 1.1 | 1.0 | 0.2 | 1.4 | 1.4 |
| Bone: elastic displacement | 1.3 | 1.4 | 2.4 | -1.1 | -1.5 | -0.8 | -0.0 | -1.5 | -1.4 |
| Latency to leave start box in cocaine runway, F | 1.3 | 1.4 | 2.5 | -0.8 | -1.5 | -0.0 | 1.5 | -1.6 | -1.0 |
| K content in liver | 1.3 | 1.3 | 4.1 | -1.0 | -0.0 | -1.5 | -2.0 | -0.2 | -0.8 |
| Total locomotion distance, hab. session 2 | 1.2 | 1.5 | 4.2 | 0.5 | -2.1 | 0.6 | 1.6 | -1.0 | -0.8 |
| Locomotion velocity, hab. session 2 | 1.2 | 1.6 | 4.8 | 0.2 | -2.2 | 0.3 | 1.4 | -1.3 | -1.1 |
| Bone volume | 1.2 | 2.1 | 4.2 | 1.3 | 1.8 | 0.6 | -0.9 | 2.0 | 1.5 |
| Bone: connectivity density | 1.2 | 1.9 | 4.1 | -0.9 | -1.2 | -1.8 | -2.0 | -0.7 | -1.3 |
| Na content in liver | 1.2 | 1.2 | 2.2 | -1.2 | -0.3 | -1.4 | -1.5 | -0.7 | -1.0 |
| Tibialis anterior weight | 1.1 | 3.6 | 10.0 | 1.8 | 0.4 | 2.5 | 3.2 | 0.6 | 1.4 |
| Locomotor testing rearing | 1.1 | 1.7 | 4.1 | 1.5 | -1.1 | 1.5 | 2.0 | 0.2 | 0.5 |
| Progressive ratio test 2 inactive lever presses | 1.1 | 1.2 | 2.5 | 1.4 | 1.1 | 0.8 | -0.3 | 1.6 | 1.1 |
| Compulsive drug intake | 1.1 | 1.1 | 2.9 | 0.2 | 1.7 | 0.0 | -1.0 | 1.3 | 1.0 |
| Bone: cortical area | 1.1 | 1.6 | 3.4 | 1.9 | 0.2 | 1.5 | 1.0 | 1.1 | 1.2 |
| Time >=10cm from walls, locomotor time 2 | 1.1 | 1.2 | 3.1 | -0.4 | -1.8 | 0.1 | 1.2 | -1.4 | -0.7 |
| Total resting periods, locomotor time 2 | 1.1 | 1.1 | 4.6 | 0.5 | -0.1 | 1.3 | 2.2 | -0.4 | 0.4 |
| Latency to leave start box in cocaine runway, M | 1.1 | 1.1 | 2.9 | -0.5 | -1.7 | -0.8 | -0.1 | -1.1 | -1.2 |
| Tail length | 1.0 | 3.0 | 5.2 | 2.3 | 1.3 | 1.7 | 0.5 | 2.2 | 1.9 |
| Tibia length | 1.0 | 2.8 | 3.6 | 1.5 | 1.8 | 1.9 | 1.4 | 1.6 | 1.9 |
| Water consumed over 24 hours | 1.0 | 1.2 | 3.2 | 0.5 | -1.8 | 0.6 | 1.4 | -0.9 | -0.7 |
| Indifference point function ln k | 1.0 | 1.4 | 1.8 | -1.2 | -1.0 | -1.3 | -1.2 | -1.1 | -1.2 |
| Indifference point function log k | 1.0 | 1.4 | 1.8 | -1.2 | -1.0 | -1.3 | -1.2 | -1.1 | -1.2 |
| Locomotor testing distance | 1.0 | 1.6 | 3.4 | 1.7 | -0.6 | 1.6 | 1.8 | 0.5 | 0.6 |
| Reaction time number correct | 1.0 | 1.4 | 2.0 | -1.4 | -0.4 | -1.4 | -1.4 | -0.9 | -1.3 |
| Reaction time trials correct on left | 1.0 | 1.4 | 2.0 | -1.4 | -0.4 | -1.4 | -1.4 | -0.9 | -1.3 |
| Reaction time trials AUC | 1.0 | 1.5 | 2.2 | -1.4 | -0.4 | -1.4 | -1.5 | -0.8 | -1.3 |
| Conditioned reinforcement - inactives | 1.0 | 1.2 | 1.6 | 1.2 | 1.1 | 1.1 | 0.5 | 1.3 | 1.2 |
| Intermitt. access escalation Index | 1.0 | 0.9 | 1.6 | -1.0 | -0.5 | -1.3 | -1.2 | -0.6 | -0.8 |
| Post-drug Anxiety | 1.0 | 1.1 | 2.1 | -1.4 | -0.1 | -1.3 | -1.0 | -0.9 | -0.9 |
| Locomotion velocity, session 2 | 1.0 | 1.1 | 3.2 | -0.4 | -1.8 | -0.9 | -0.7 | -0.8 | -1.2 |
| Condit. Reinf. active-inactive response ratio | 1.0 | 1.1 | 2.0 | 0.8 | 1.4 | 0.5 | -0.5 | 1.4 | 1.2 |
| Locomotion velocity, NPP test | 1.0 | 1.4 | 5.0 | 0.2 | -2.2 | 0.1 | 0.8 | -1.2 | -1.2 |
| Bone surface | 1.0 | 1.8 | 3.8 | 1.2 | 1.4 | 0.1 | -1.5 | 2.0 | 1.2 |
| Bone: stiffness | 1.0 | 1.6 | 2.6 | 1.6 | 1.0 | 1.1 | 0.2 | 1.6 | 1.5 |
| Breakpoint value in progressive ratio session | 1.0 | 1.1 | 2.5 | -0.5 | -1.6 | -0.1 | 0.9 | -1.4 | -0.9 |
| Delta distance traveled before/after self-admin | 1.0 | 1.0 | 3.2 | -0.2 | -1.8 | -0.2 | 0.6 | -1.1 | -1.1 |
| Cd content in liver | 1.0 | 1.1 | 2.6 | -1.6 | 0.2 | -1.3 | -1.0 | -0.8 | -0.9 |
| Zn content in liver | 1.0 | 1.1 | 2.3 | -1.4 | 0.2 | -1.4 | -1.5 | -0.5 | -0.8 |
| Liver weight, right | 0.9 | 1.4 | 2.2 | -1.1 | -1.4 | -1.1 | -0.5 | -1.3 | -1.5 |
| Light reinforcement 1 | 0.9 | 1.7 | 4.8 | -0.0 | -2.2 | 0.1 | 1.2 | -1.5 | -1.3 |
| Reaction time trials on left | 0.9 | 1.3 | 2.1 | -1.3 | -0.3 | -1.4 | -1.4 | -0.8 | -1.3 |
| Reaction time trials completed | 0.9 | 1.3 | 2.1 | -1.3 | -0.3 | -1.4 | -1.4 | -0.8 | -1.3 |
| Short access day 1 locomotion | 0.9 | 0.9 | 2.1 | 1.4 | -0.6 | 1.2 | 1.2 | 0.3 | 0.5 |
| Total zone transitions, hab. session 2 | 0.9 | 1.2 | 3.8 | 0.5 | -1.2 | 0.9 | 2.0 | -0.8 | -0.3 |
| Pavlov. Cond. magazine entry number | 0.9 | 1.1 | 2.0 | -1.4 | -0.7 | -1.1 | -0.4 | -1.3 | -1.1 |
| Pavlov. Cond. response bias | 0.9 | 1.2 | 2.1 | 1.4 | 0.4 | 1.3 | 0.9 | 1.1 | 1.1 |
| Time in closed arm before self-admin | 0.9 | 1.0 | 3.6 | 0.6 | -1.9 | 0.3 | 1.0 | -0.6 | -0.5 |
| Time to tail flick, test, after self-admin | 0.9 | 0.9 | 2.0 | 0.9 | 1.1 | 0.3 | -0.7 | 1.4 | 1.0 |
| Sr content in liver | 0.9 | 0.8 | 1.3 | 0.8 | 0.7 | 1.1 | 1.2 | 0.6 | 0.9 |
| Length without tail | 0.8 | 1.7 | 2.9 | 0.9 | 1.7 | 1.3 | 0.9 | 1.2 | 1.6 |
| Delay discounting water rate 24 sec | 0.8 | 1.1 | 1.8 | -1.2 | -0.8 | -1.2 | -0.7 | -1.1 | -1.3 |
| Delay discounting water rate 6 sec | 0.8 | 1.2 | 2.0 | -0.8 | -1.4 | -0.8 | -0.3 | -1.3 | -1.4 |
| Total zone transitions, NPP test | 0.8 | 1.2 | 3.4 | -0.2 | -1.9 | -0.0 | 0.8 | -1.3 | -1.1 |
| Bone: trabecular thickness | 0.8 | 0.9 | 1.6 | 1.0 | 1.2 | 0.6 | -0.3 | 1.3 | 1.0 |
| Distance traveled before self-admin | 0.8 | 0.9 | 1.6 | -1.3 | -0.2 | -1.1 | -1.0 | -0.7 | -0.9 |
| Time to tail flick, vehicle, before self-admin | 0.8 | 0.8 | 2.9 | -0.3 | 1.7 | -0.2 | -0.9 | 0.8 | 0.7 |
| Fecal boli incidents, locomotor time 1 | 0.8 | 0.8 | 3.6 | -0.2 | 1.9 | 0.1 | -0.3 | 0.8 | 0.9 |
| Left kidney weight | 0.7 | 1.9 | 4.0 | 1.1 | 0.7 | 1.8 | 2.0 | 0.5 | 1.4 |
| Parametrial fat weight | 0.7 | 1.3 | 4.3 | -0.5 | -0.6 | -1.3 | -2.1 | -0.2 | -1.1 |
| Extensor digitorum longus weight | 0.7 | 2.8 | 12.1 | 0.2 | 0.7 | 1.8 | 3.5 | -0.6 | 0.8 |
| Times rat made contact with spout | 0.7 | 0.8 | 1.4 | 1.2 | 0.2 | 1.1 | 0.9 | 0.8 | 0.8 |
| Pavlov. Cond. intertrial magazine entries | 0.7 | 0.9 | 3.1 | 1.7 | -0.5 | 0.7 | -0.3 | 1.1 | 0.6 |
| Short access total infusions | 0.7 | 0.8 | 2.2 | 1.5 | -0.1 | 1.0 | 0.4 | 0.9 | 0.7 |
| Number of responses in last shaping day | 0.7 | 0.8 | 1.7 | 0.9 | 0.3 | 1.1 | 1.3 | 0.4 | 0.8 |
| Locomotion distance, session 2 | 0.7 | 1.1 | 3.0 | -0.5 | -1.7 | -0.7 | -0.1 | -1.1 | -1.2 |
| Total zone transitions, hab. session 1 | 0.7 | 1.0 | 3.0 | 0.9 | -0.6 | 1.2 | 1.7 | -0.1 | 0.2 |
| Total locomotion distance, hab. session 1 | 0.7 | 0.9 | 2.4 | 0.9 | -1.5 | 0.7 | 1.3 | -0.4 | -0.4 |
| Bone: trabecular number | 0.7 | 1.2 | 3.5 | -0.7 | -0.5 | -1.4 | -1.9 | -0.2 | -0.9 |
| Ambulatory time before self-admin | 0.7 | 0.7 | 1.4 | -1.2 | -0.3 | -1.0 | -0.7 | -0.8 | -0.9 |
| Ambulatory time after self-admin | 0.7 | 0.8 | 1.7 | -0.6 | -1.3 | -0.6 | -0.2 | -0.9 | -1.2 |
| Bouts of movement, locomotor time 1 | 0.7 | 0.8 | 2.3 | 0.7 | 0.3 | 1.2 | 1.5 | 0.1 | 0.7 |
| Liver weight, left | 0.6 | 1.0 | 1.9 | -0.9 | -0.7 | -1.3 | -1.4 | -0.6 | -1.0 |
| Number of licking bursts | 0.6 | 0.7 | 1.5 | 0.6 | 1.2 | 0.7 | 0.1 | 1.0 | 1.0 |
| Std. dev. time between licks in bursts | 0.6 | 0.7 | 1.4 | -0.1 | -1.1 | 0.3 | 1.2 | -0.9 | -0.6 |
| Delay discounting water rate 0 sec | 0.6 | 0.9 | 2.2 | 1.5 | 0.4 | 1.0 | 0.0 | 1.2 | 0.8 |
| Median of all reaction times | 0.6 | 0.8 | 2.8 | -0.7 | -0.2 | -1.2 | -1.7 | -0.1 | -0.6 |
| Incentive Sensitization - Breakpoint | 0.6 | 0.6 | 2.2 | -0.5 | 0.2 | -0.9 | -1.5 | 0.2 | -0.4 |
| Progressive ratio test 2 active lever presses | 0.6 | 0.6 | 1.4 | 1.2 | 0.4 | 0.6 | -0.1 | 1.1 | 0.7 |
| Locomotion velocity, hab. session 1 | 0.6 | 0.8 | 2.1 | 0.7 | -1.5 | 0.6 | 1.2 | -0.5 | -0.4 |
| Bone: final force | 0.6 | 1.0 | 2.0 | 1.4 | 0.6 | 0.9 | -0.1 | 1.3 | 1.1 |
| Total resting periods, locomotor time 1 | 0.6 | 0.6 | 1.6 | 0.5 | 0.6 | 1.0 | 1.3 | 0.3 | 0.7 |
| Soleus weight | 0.5 | 1.6 | 2.1 | 0.9 | 1.4 | 1.4 | 1.4 | 0.9 | 1.4 |
| Delay discounting water rate 18 sec | 0.5 | 0.6 | 1.7 | -0.2 | -1.3 | -0.2 | 0.1 | -0.8 | -1.1 |
| Reaction time mean | 0.5 | 0.7 | 2.3 | -0.7 | 0.0 | -1.0 | -1.5 | -0.1 | -0.4 |
| Reaction time mean AUC | 0.5 | 0.6 | 1.8 | -0.7 | -0.2 | -1.0 | -1.4 | -0.2 | -0.5 |
| Cocaine induced anxiety | 0.5 | 0.6 | 1.0 | -0.8 | -0.6 | -1.0 | -0.9 | -0.6 | -0.8 |
| Incentive Sensitization - Responses | 0.5 | 0.5 | 1.7 | -0.4 | 0.2 | -0.8 | -1.3 | 0.2 | -0.3 |
| Progressive ratio test 2 breakpoint | 0.5 | 0.6 | 1.6 | 1.3 | 0.1 | 0.6 | -0.2 | 1.1 | 0.6 |
| Bone: final moment | 0.5 | 0.9 | 1.9 | 1.4 | 0.5 | 0.7 | -0.3 | 1.3 | 1.0 |
| Delta time in closed arm before/after self-admin | 0.5 | 0.4 | 1.3 | -0.6 | 0.7 | -0.7 | -1.1 | 0.2 | -0.0 |
| Diff in mean of infusions in LGA sessions | 0.5 | 0.6 | 2.3 | -0.1 | -0.4 | 0.7 | 1.5 | -0.8 | -0.1 |
| Time to tail flick, vehicle, after self-admin | 0.5 | 0.6 | 1.5 | 0.0 | 1.2 | -0.4 | -0.9 | 0.9 | 0.4 |
| Seeking ratio, delayed vs. immediate footshock | 0.5 | 0.6 | 0.9 | 0.5 | 1.0 | 0.9 | 0.7 | 0.6 | 0.9 |
| Seeking ratio, punishment vs. effort | 0.5 | 0.6 | 1.5 | 1.2 | -1.2 | 0.5 | 0.5 | 0.3 | 0.1 |
| Indifference point AUC | 0.4 | 0.5 | 0.8 | 0.8 | 0.6 | 0.7 | 0.3 | 0.8 | 0.9 |
| Reaction time premature initiations | 0.4 | 0.6 | 0.7 | 0.8 | 0.8 | 0.9 | 0.4 | 0.7 | 0.8 |
| Cocaine response after cond. not corrected | 0.4 | 0.5 | 1.5 | -0.1 | 1.2 | 0.1 | -0.4 | 0.7 | 0.8 |
| Pavlov. Cond. index score | 0.4 | 0.5 | 0.9 | 0.6 | 0.9 | 0.5 | -0.1 | 1.0 | 0.9 |
| Pavlov. Cond. latency score | 0.4 | 0.5 | 0.9 | 0.4 | 1.0 | 0.3 | -0.3 | 0.9 | 0.8 |
| One hour access (shock baseline) | 0.4 | 0.5 | 1.2 | 1.1 | 0.1 | 0.8 | 0.5 | 0.7 | 0.7 |
| Locomotion distance, session 7 | 0.4 | 0.5 | 0.9 | 0.6 | 1.0 | 0.6 | 0.2 | 0.9 | 0.9 |
| Delta time to tail flick, vehicle, before/after SA | 0.4 | 0.3 | 1.2 | 0.3 | -0.4 | -0.6 | -1.1 | 0.4 | -0.3 |
| Delta time to tail flick, test, before/after SA | 0.4 | 0.3 | 0.9 | -0.0 | 0.7 | -0.4 | -0.9 | 0.6 | 0.3 |
| Delay disc. indifference point, 4s delay | 0.4 | 0.4 | 0.9 | -0.9 | 0.1 | -0.8 | -0.6 | -0.5 | -0.5 |
| Change in fecal boli incidents, locomotor task | 0.4 | 0.4 | 1.2 | -0.2 | -0.6 | -0.6 | -1.1 | -0.2 | -0.6 |
| Distance moved, locomotor task time 1 | 0.4 | 0.5 | 1.3 | 0.5 | -1.1 | 0.5 | 0.9 | -0.4 | -0.3 |
| Progressive ratio | 0.4 | 0.4 | 1.7 | -0.7 | 1.3 | -0.3 | -0.5 | 0.2 | 0.2 |
| Food seeking constrained by brief footshock | 0.4 | 0.4 | 1.1 | 1.1 | 0.0 | 0.4 | -0.2 | 1.0 | 0.6 |
| Reaction time mean minus median AUC | 0.3 | 0.4 | 1.4 | -0.5 | 0.5 | -0.8 | -1.2 | 0.1 | -0.2 |
| Social time | 0.3 | 0.4 | 1.0 | 0.2 | 1.0 | 0.3 | -0.0 | 0.7 | 0.7 |
| Cocaine response after cond. corrected | 0.3 | 0.4 | 1.3 | 0.1 | 1.1 | 0.2 | -0.3 | 0.6 | 0.7 |
| Pavlov. Cond. lever latency | 0.3 | 0.4 | 0.9 | -0.6 | -0.5 | -0.1 | 0.7 | -1.0 | -0.6 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.3 | 0.4 | 0.8 | 0.4 | 0.9 | 0.3 | -0.2 | 0.9 | 0.8 |
| Locomotion velocity, session 7 | 0.3 | 0.4 | 0.7 | -0.6 | -0.7 | -0.3 | 0.3 | -0.9 | -0.6 |
| Condit. Reinf. inactive responses | 0.3 | 0.4 | 0.9 | 0.9 | -0.2 | 0.7 | 0.4 | 0.5 | 0.5 |
| Condit. Reinf. lever presses | 0.3 | 0.4 | 1.4 | 0.5 | -0.3 | 0.7 | 1.2 | -0.1 | 0.3 |
| Bone: elastic work | 0.3 | 0.4 | 1.0 | 0.4 | -0.9 | 0.5 | 1.0 | -0.4 | -0.2 |
| Distance traveled after self-admin | 0.3 | 0.4 | 0.6 | -0.7 | -0.6 | -0.6 | -0.2 | -0.6 | -0.8 |
| Active lever presses in extinction session 6 | 0.3 | 0.3 | 0.7 | 0.8 | -0.8 | 0.6 | 0.5 | 0.1 | -0.1 |
| Delta ambulatory time before/after self-admin | 0.3 | 0.3 | 1.4 | 0.3 | -1.2 | -0.1 | 0.1 | -0.3 | -0.6 |
| Time in open arm after self-admin | 0.3 | 0.4 | 1.8 | -0.4 | 1.3 | 0.2 | 0.0 | 0.2 | 0.4 |
| Delay disc. indifference point, 2s delay | 0.3 | 0.3 | 1.3 | -0.4 | 0.4 | -0.6 | -1.1 | 0.2 | -0.3 |
| Delay discount exponential model param | 0.3 | 0.3 | 1.3 | -0.1 | -1.1 | -0.2 | 0.1 | -0.5 | -0.5 |
| Time >=10cm from walls, locomotor time 1 | 0.3 | 0.3 | 0.8 | -0.9 | -0.1 | -0.6 | -0.4 | -0.5 | -0.4 |
| Vertical activity count, locomotor time 1 | 0.3 | 0.3 | 0.5 | 0.6 | -0.6 | 0.6 | 0.7 | -0.0 | 0.1 |
| Weight adjusted by age | 0.3 | 0.4 | 1.3 | -0.5 | 0.5 | 0.4 | 1.1 | -0.6 | 0.1 |
| Run reversals in cocaine runway, males | 0.3 | 0.3 | 0.6 | -0.8 | 0.1 | -0.7 | -0.5 | -0.4 | -0.5 |
| Intraocular pressure | 0.2 | 0.2 | 0.6 | 0.5 | 0.0 | 0.7 | 0.8 | 0.1 | 0.4 |
| Mean num. licks in bursts | 0.2 | 0.3 | 0.9 | 0.1 | -1.0 | -0.0 | 0.5 | -0.5 | -0.5 |
| Reaction time omissions | 0.2 | 0.3 | 0.5 | 0.7 | 0.5 | 0.4 | -0.3 | 0.7 | 0.5 |
| Std. dev. reaction times | 0.2 | 0.3 | 1.0 | -0.2 | 0.6 | -0.5 | -1.0 | 0.4 | 0.1 |
| Social response proportion | 0.2 | 0.3 | 0.5 | 0.7 | 0.2 | 0.5 | -0.2 | 0.7 | 0.5 |
| Conditioned locomotion | 0.2 | 0.2 | 0.2 | -0.3 | -0.5 | -0.5 | -0.5 | -0.3 | -0.5 |
| Condit. Reinf. inactive responses | 0.2 | 0.3 | 0.8 | 0.9 | -0.8 | 0.3 | -0.1 | 0.4 | -0.0 |
| Pavlov. Cond. lever contacts | 0.2 | 0.2 | 0.6 | 0.8 | -0.0 | 0.3 | -0.3 | 0.7 | 0.4 |
| Context. condit. distance diff. score | 0.2 | 0.2 | 0.4 | 0.3 | 0.5 | 0.6 | 0.5 | 0.2 | 0.6 |
| Degree of sensitization distance | 0.2 | 0.2 | 0.4 | 0.6 | 0.3 | 0.4 | -0.0 | 0.6 | 0.5 |
| Bone: apparent density | 0.2 | 0.3 | 1.2 | -0.1 | 0.2 | -0.6 | -1.1 | 0.3 | -0.1 |
| Bone: trabecular spacing | 0.2 | 0.3 | 1.1 | 0.3 | -0.1 | 0.7 | 1.1 | -0.1 | 0.3 |
| Extinction: sum of active levers before priming | 0.2 | 0.2 | 0.5 | -0.1 | -0.7 | 0.1 | 0.5 | -0.5 | -0.4 |
| Delay disc. indifference point, 8s delay | 0.2 | 0.2 | 0.6 | -0.7 | 0.0 | -0.3 | 0.2 | -0.7 | -0.5 |
| Delay discount hyperbolic model param | 0.2 | 0.2 | 0.8 | 0.1 | -0.9 | -0.0 | 0.2 | -0.3 | -0.3 |
| Rest time, locomotor task time 1 | 0.2 | 0.2 | 0.7 | -0.9 | 0.4 | -0.5 | -0.3 | -0.3 | -0.1 |
| Locomotion in novel chamber | 0.2 | 0.3 | 0.6 | -0.8 | -0.2 | -0.4 | -0.1 | -0.7 | -0.5 |
| Locomotion in novel chamber post-restriction | 0.2 | 0.2 | 0.5 | 0.6 | 0.3 | 0.3 | -0.3 | 0.7 | 0.3 |
| Co content in liver | 0.2 | 0.2 | 0.8 | -0.2 | 0.9 | 0.2 | 0.2 | 0.2 | 0.5 |
| Glucose | 0.1 | 0.2 | 0.7 | -0.8 | 0.4 | -0.3 | 0.2 | -0.4 | -0.2 |
| Delay discounting time to switch 0 sec | 0.1 | 0.1 | 0.3 | 0.0 | 0.4 | 0.3 | 0.6 | 0.1 | 0.4 |
| Delay discounting water rate 12 sec | 0.1 | 0.1 | 0.4 | 0.2 | -0.0 | 0.5 | 0.6 | -0.1 | 0.0 |
| Light reinforcement 2 | 0.1 | 0.1 | 0.3 | -0.4 | -0.1 | -0.1 | 0.3 | -0.6 | -0.4 |
| Reaction time mean minus median | 0.1 | 0.1 | 0.5 | -0.0 | 0.7 | 0.1 | -0.0 | 0.3 | 0.3 |
| Cocaine response before conditioning | 0.1 | 0.1 | 0.3 | -0.5 | 0.0 | -0.5 | -0.4 | -0.2 | -0.1 |
| Pavlov. Cond. magazine entry latency | 0.1 | 0.1 | 0.4 | -0.7 | 0.5 | -0.2 | 0.0 | -0.2 | -0.0 |
| Pavlov. Cond. change in total contacts | 0.1 | 0.2 | 0.4 | 0.4 | 0.4 | 0.1 | -0.4 | 0.7 | 0.4 |
| Pavlov. Cond. magazine entry number | 0.1 | 0.2 | 0.4 | 0.7 | -0.3 | 0.0 | -0.4 | 0.4 | 0.1 |
| Pavlov. Cond. response bias | 0.1 | 0.2 | 0.4 | 0.5 | 0.2 | 0.2 | -0.3 | 0.6 | 0.4 |
| Intermittent access day 1 total infusions | 0.1 | 0.1 | 0.3 | 0.5 | -0.2 | 0.2 | -0.0 | 0.3 | 0.0 |
| Short access day 1 total inactive lever presses | 0.1 | 0.1 | 0.1 | 0.2 | 0.3 | 0.3 | 0.1 | 0.3 | 0.2 |
| Short access day 1 total infusions | 0.1 | 0.1 | 0.4 | 0.0 | -0.7 | 0.0 | 0.2 | -0.4 | -0.4 |
| Locomotion distance, session 3 | 0.1 | 0.1 | 0.2 | -0.4 | 0.4 | -0.3 | -0.3 | -0.0 | 0.1 |
| Locomotion distance, session 8 | 0.1 | 0.1 | 0.5 | 0.1 | -0.7 | 0.0 | 0.1 | -0.3 | -0.1 |
| Time in closed arm after self-admin | 0.1 | 0.2 | 0.3 | 0.5 | -0.4 | 0.4 | 0.5 | 0.2 | 0.2 |
| Sum of active levers in priming session hrs 5-6 | 0.1 | 0.1 | 0.3 | 0.4 | -0.1 | 0.5 | 0.6 | 0.1 | 0.2 |
| Area under the delay curve | 0.1 | 0.1 | 0.6 | -0.2 | 0.8 | 0.0 | -0.0 | 0.2 | 0.2 |
| Delay disc. indifference point, 0s delay | 0.1 | 0.1 | 0.4 | -0.6 | 0.6 | -0.3 | -0.1 | -0.2 | -0.1 |
| Delay disc. indifference point, 16s delay | 0.1 | 0.1 | 0.2 | 0.3 | 0.3 | 0.5 | 0.4 | 0.2 | 0.2 |
| Cu content in liver | 0.1 | 0.2 | 0.6 | -0.2 | 0.2 | -0.4 | -0.8 | 0.2 | -0.1 |
| Fe content in liver | 0.1 | 0.1 | 0.1 | -0.1 | -0.4 | -0.3 | -0.3 | -0.2 | -0.3 |
| Total sessions with >9 infusions | 0.0 | 0.0 | 0.1 | 0.3 | 0.1 | 0.3 | 0.2 | 0.1 | 0.2 |
| Locomotion velocity, session 1 | 0.0 | 0.0 | 0.0 | 0.2 | -0.1 | 0.1 | -0.1 | 0.1 | -0.2 |
| Locomotion distance, session 1 | 0.0 | 0.0 | 0.1 | -0.0 | -0.2 | 0.1 | 0.3 | -0.2 | -0.1 |
| Locomotion velocity, session 8 | 0.0 | 0.1 | 0.2 | -0.1 | 0.2 | -0.2 | -0.5 | 0.2 | 0.0 |
| Bone: trabecular tissue density | 0.0 | 0.0 | 0.1 | -0.1 | 0.0 | 0.2 | 0.3 | -0.3 | -0.2 |
| Total heroin consumption | 0.0 | 0.1 | 0.1 | 0.3 | -0.1 | 0.1 | -0.3 | 0.3 | 0.1 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.