Hub : Genes

Hsph1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000000902 0.56 0.15 0.0e+00 0.22 0.17 0.22 0.01 8.5e-24 7.4e-19 1.8e-24 1.1e-02
2 BLA gene expression ENSRNOG00000000902 0.12 0.08 3.3e-03 0.03 0.04 0.03 0.03 6.2e-03 3.4e-03 7.4e-03 9.3e-03
3 BLA mRNA stability ENSRNOG00000000902 0.44 0.12 3.4e-12 0.24 0.23 0.21 0.23 4.1e-13 8.0e-13 2.2e-11 1.4e-12
4 Brain gene expression ENSRNOG00000000902 0.07 0.04 8.1e-05 0.03 0.04 0.03 0.03 4.6e-04 1.1e-04 7.4e-04 1.7e-03
5 Brain mRNA stability ENSRNOG00000000902 0.3 0.14 0.0e+00 0.3 0.31 0.3 0.3 1.0e-27 4.0e-29 4.0e-28 1.4e-28
6 IL mRNA stability ENSRNOG00000000902 0.11 0.08 2.3e-03 0.08 0.1 0.05 0.06 7.2e-03 2.1e-03 2.2e-02 1.4e-02
7 Liver intron excision ratio chr12:5393434:5395341 0.08 0.05 5.3e-11 0.07 0.07 0.06 0.06 2.5e-08 3.9e-08 4.0e-07 1.1e-07
8 Liver mRNA stability ENSRNOG00000000902 0.03 0.02 1.3e-03 0.02 0.01 0.01 0.01 2.5e-03 1.0e-02 1.2e-02 2.6e-02
9 NAcc gene expression ENSRNOG00000000902 0.1 0.05 3.9e-10 0.15 0.13 0.14 0.14 5.1e-11 6.6e-10 1.3e-10 2.4e-10
10 NAcc mRNA stability ENSRNOG00000000902 0.17 0.07 4.0e-15 0.21 0.2 0.2 0.2 1.9e-15 3.8e-15 4.3e-15 3.5e-15
11 OFC gene expression ENSRNOG00000000902 0.12 0.09 4.7e-03 0.09 0.09 0.07 0.09 3.1e-03 4.0e-03 1.0e-02 4.4e-03
12 OFC mRNA stability ENSRNOG00000000902 0.28 0.14 5.9e-07 0.24 0.24 0.19 0.23 1.5e-06 2.4e-06 2.8e-05 3.5e-06
13 PL mRNA stability ENSRNOG00000000902 0.14 0.07 1.8e-11 0.15 0.15 0.14 0.15 8.3e-12 1.2e-11 4.1e-11 2.6e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
BMI with tail1.34.311.5-2.4-0.9-1.7-1.1-2.2-2.41.9-2.81.6-1.63.4-1.8-1.8
BMI without tail0.81.74.10.3-1.81.5-2.01.21.0-1.40.5-1.51.5-0.11.31.2
Body weight4.418.855.4-6.8-5.1-2.1-5.4-3.1-3.62.4-6.21.7-1.77.4-2.0-2.4
Epididymis fat weight2.76.38.4-2.60.8-2.90.7-2.8-2.92.7-2.92.2-2.22.9-2.8-2.7
Glucose0.40.61.0-0.50.8-0.80.7-0.8-0.60.8-0.60.9-0.90.7-1.0-0.7
Heart weight0.91.32.4-0.3-1.51.2-1.41.01.0-1.10.1-1.61.60.11.31.2
Left kidney weight2.77.822.4-4.7-3.5-1.3-3.8-1.6-2.01.2-4.20.9-0.94.5-1.1-1.2
Right kidney weight3.610.429.2-5.4-3.6-2.0-3.8-2.1-2.51.8-4.91.4-1.45.1-1.7-1.8
Tail length1.95.917.4-0.7-4.02.4-4.22.11.8-2.30.3-2.52.50.42.52.2
Length with tail3.011.033.8-5.4-5.6-0.2-5.8-1.0-1.50.4-4.30.2-0.25.3-0.2-0.5
Length without tail8.618.946.8-6.5-2.6-3.4-2.7-4.0-4.43.6-6.13.3-3.36.8-3.3-3.4
Liver weight, left2.23.69.8-3.0-1.4-1.3-1.4-1.7-1.91.2-2.71.5-1.53.1-1.4-1.2
Liver weight, right2.74.513.7-3.7-3.2-0.7-3.2-0.9-1.20.6-3.00.3-0.33.3-0.5-0.5
Parametrial fat weight0.10.20.4-0.5-0.6-0.1-0.5-0.3-0.20.4-0.4-0.20.20.6-0.1-0.4
Retroperitoneal fat weight3.310.915.0-2.32.1-3.72.2-3.9-3.83.8-2.73.4-3.43.3-3.9-3.8
Intraocular pressure0.40.51.3-0.60.2-1.1-0.0-0.8-0.90.8-1.00.4-0.40.6-0.9-0.9
Extensor digitorum longus weight0.93.48.9-3.0-1.6-1.1-2.1-1.2-1.71.1-2.71.1-1.13.0-1.2-1.1
Soleus weight0.71.94.7-2.2-0.6-0.9-0.9-1.0-1.51.0-2.11.3-1.32.1-1.0-1.0
Tibialis anterior weight1.03.510.9-3.3-3.00.0-3.3-0.4-0.90.2-2.70.2-0.22.6-0.0-0.1
Tibia length1.23.510.3-3.0-2.5-0.9-2.7-0.9-1.10.8-2.70.7-0.73.2-0.6-0.8
Number of licking bursts1.01.24.0-0.9-2.01.0-2.00.80.8-0.7-0.4-0.70.71.11.00.6
Food consumed during 24 hour testing period1.51.93.01.7-0.31.4-0.31.41.4-1.31.6-1.41.4-1.71.41.4
Times rat made contact with spout1.51.73.5-0.3-1.81.4-1.91.41.4-1.50.2-1.21.20.21.41.6
Mean time between licks in bursts0.40.61.81.20.50.60.60.80.8-0.51.0-0.60.6-1.40.70.3
Mean num. licks in bursts0.30.41.10.80.50.30.50.40.4-0.60.8-0.40.4-1.10.30.7
Std. dev. time between licks in bursts0.00.00.20.2-0.00.2-0.00.10.10.3-0.0-0.20.2-0.50.1-0.3
Water consumed over 24 hours1.21.54.3-0.5-2.01.1-2.11.10.9-1.20.1-1.01.00.41.21.3
Indifference point 0 sec1.22.04.9-1.3-0.3-1.3-0.3-1.6-1.71.5-1.61.2-1.22.2-1.3-1.6
Indifference point AUC0.30.31.5-0.4-1.20.4-1.20.30.2-0.2-0.2-0.60.60.30.50.3
Indifference point function ln k0.20.21.2-1.1-0.3-0.4-0.4-0.1-0.10.0-0.80.3-0.30.7-0.3-0.1
Indifference point function log k0.20.21.2-1.1-0.3-0.4-0.4-0.1-0.10.0-0.80.3-0.30.7-0.3-0.1
Delay discounting total patch changes 0 sec1.11.84.7-1.3-0.3-1.2-0.3-1.5-1.61.3-1.51.2-1.22.2-1.2-1.5
Delay discounting total patch changes 12 sec1.72.23.9-1.4-0.1-1.5-0.1-1.8-1.91.7-1.61.2-1.22.0-1.5-1.8
Delay discounting total patch changes 18 sec0.30.40.8-0.20.1-0.70.1-0.8-0.90.8-0.40.5-0.50.6-0.7-0.9
Delay discounting total patch changes 24 sec0.30.31.10.1-0.3-0.2-0.2-0.7-0.80.8-0.20.4-0.41.1-0.4-0.8
Delay discounting total patch changes 6 sec0.20.30.9-0.2-0.4-0.3-0.4-0.6-0.80.6-0.40.2-0.20.9-0.4-0.7
Delay discounting time to switch 0 sec0.91.46.11.52.3-0.52.5-0.5-0.40.80.90.3-0.3-1.3-0.5-1.0
Delay discounting water rate 0 sec1.01.55.7-1.8-2.2-0.1-2.4-0.2-0.40.0-1.40.2-0.21.9-0.10.0
Delay discounting water rate 12 sec0.60.83.0-1.2-1.70.5-1.70.40.4-0.7-0.6-0.20.21.20.40.7
Delay discounting water rate 18 sec0.81.11.60.8-0.81.3-0.81.11.2-1.21.1-1.01.0-0.71.11.3
Delay discounting water rate 24 sec2.02.87.9-0.8-2.81.8-2.81.41.3-1.8-0.1-1.51.50.31.51.7
Delay discounting water rate 6 sec0.71.02.5-1.6-0.9-0.6-0.9-0.9-0.80.6-1.40.9-0.91.5-0.8-0.6
Locomotor activity0.40.62.4-0.7-1.50.4-1.50.40.4-0.6-0.5-0.70.70.50.60.5
Locomotor testing distance0.10.20.7-0.4-0.8-0.1-0.9-0.00.0-0.1-0.2-0.40.40.70.10.1
Locomotor testing rearing0.00.00.1-0.0-0.1-0.10.0-0.10.0-0.20.00.1-0.10.3-0.10.1
Light reinforcement 10.20.42.01.11.2-0.11.4-0.00.20.00.70.2-0.2-0.7-0.3-0.0
Light reinforcement 20.20.31.00.50.9-0.61.0-0.4-0.20.70.20.4-0.4-0.5-0.5-0.5
Reaction time number correct0.50.72.4-1.0-1.40.4-1.50.30.1-0.6-0.6-0.20.21.20.40.7
Reaction time mean minus median1.72.24.71.70.31.40.31.61.7-1.61.8-1.51.5-2.21.41.4
Reaction time mean minus median AUC1.41.84.41.70.91.20.91.31.5-1.41.7-1.11.1-2.11.01.2
Reaction time num false alarms0.30.42.00.2-0.10.6-0.10.70.7-0.50.3-0.70.7-1.40.50.6
Reaction time num false alarms AUC0.00.10.7-0.20.10.10.10.00.0-0.0-0.1-0.20.2-0.8-0.10.0
Reaction time trials correct on left0.50.72.4-1.0-1.40.4-1.50.30.1-0.6-0.6-0.20.21.20.40.7
Reaction time trials on left0.50.72.4-1.0-1.40.4-1.50.40.2-0.7-0.6-0.20.21.20.40.7
Reaction time mean1.82.58.42.42.40.32.50.60.9-0.52.1-0.50.5-2.90.30.4
Reaction time mean AUC1.82.38.22.32.40.32.50.50.8-0.41.9-0.40.4-2.90.20.2
Median of all reaction times1.82.59.02.22.8-0.23.00.00.40.11.80.0-0.0-2.6-0.3-0.2
Reaction time omissions0.50.72.61.11.10.41.10.60.8-0.71.0-0.40.4-1.60.30.4
Reaction time false alarm rate0.20.21.40.10.7-0.20.8-0.2-0.10.40.0-0.00.0-1.2-0.3-0.4
Reaction time premature initiation rate3.85.18.12.3-0.12.10.02.32.4-2.62.7-2.52.5-2.82.22.4
Reaction time premature initiations3.34.87.91.7-0.92.3-0.82.42.3-2.82.2-2.42.4-2.02.32.7
Std. dev. reaction times1.41.96.11.91.11.01.21.11.4-1.21.8-1.11.1-2.50.91.0
Reaction time trials completed0.50.72.4-1.0-1.40.4-1.50.40.2-0.7-0.6-0.20.21.20.40.7
Reaction time trials AUC0.40.62.0-1.1-1.30.2-1.40.20.0-0.5-0.8-0.00.01.30.30.5
Social response proportion1.61.73.6-0.2-1.81.4-1.91.41.3-1.40.1-1.31.30.11.51.4
Social responses1.31.73.30.6-1.21.8-1.31.41.4-1.60.7-1.41.4-0.41.41.5
Social time0.30.41.71.11.1-0.01.3-0.00.30.10.8-0.10.1-0.6-0.2-0.0
Conditioned locomotion0.20.20.50.3-0.60.3-0.70.30.1-0.30.3-0.60.6-0.00.40.4
Cocaine response after cond. corrected0.80.93.01.21.7-0.71.5-0.6-0.60.90.50.6-0.6-0.5-0.8-0.9
Cocaine response after cond. not corrected1.11.23.61.31.9-0.91.8-0.8-0.81.10.50.8-0.8-0.5-1.0-1.1
Cocaine response before conditioning0.20.30.5-0.50.0-0.50.1-0.7-0.60.6-0.50.6-0.60.5-0.5-0.6
Saline control response3.95.210.2-0.4-3.22.6-3.02.12.1-2.60.4-2.52.5-0.42.42.6
Condit. Reinf. active minus inactive responses1.01.31.80.2-1.31.3-1.21.21.2-1.20.6-1.41.4-0.51.41.1
Condit. Reinf. active-inactive response ratio1.92.02.90.6-1.31.6-1.11.41.5-1.61.1-1.71.7-0.91.71.5
Condit. Reinf. active responses0.60.82.2-0.3-1.51.0-1.40.80.8-0.90.2-1.01.00.01.00.8
Condit. Reinf. inactive responses0.10.20.5-0.6-0.5-0.2-0.5-0.2-0.30.2-0.60.2-0.20.7-0.2-0.3
Condit. Reinf. lever presses0.30.41.2-0.6-0.5-0.4-0.4-0.7-0.80.4-0.50.5-0.51.1-0.4-0.5
Condit. Reinf. lever reinforcers received0.50.82.2-0.4-1.50.9-1.30.70.7-0.80.1-1.01.00.20.90.7
Pavlov. Cond. lever latency0.00.10.1-0.30.3-0.30.2-0.1-0.10.2-0.40.3-0.30.1-0.3-0.1
Pavlov. Cond. magazine entry latency0.20.21.00.40.8-0.01.0-0.00.10.20.30.1-0.1-0.90.0-0.3
Pavlov. Cond. change in total contacts0.10.10.6-0.6-0.80.2-0.6-0.10.0-0.1-0.4-0.30.30.30.2-0.0
Pavlov. Cond. index score0.10.10.20.30.00.30.20.10.2-0.20.4-0.20.2-0.50.30.0
Pavlov. Cond. latency score0.00.00.20.20.10.10.30.00.1-0.00.3-0.10.1-0.50.2-0.1
Pavlov. Cond. lever contacts0.10.20.60.80.5-0.40.6-0.5-0.40.40.50.3-0.3-0.0-0.2-0.5
Pavlov. Cond. magazine entry number0.20.21.0-0.3-0.80.3-1.00.20.1-0.4-0.2-0.30.30.50.20.5
Pavlov. Cond. intertrial magazine entries0.60.81.70.1-1.31.0-1.30.90.8-0.90.5-0.90.90.10.90.9
Pavlov. Cond. lever-magazine prob. diff.0.10.10.20.3-0.10.30.10.20.3-0.20.4-0.30.3-0.40.40.1
Pavlov. Cond. response bias0.30.31.01.00.9-0.41.0-0.4-0.30.40.70.2-0.2-0.4-0.2-0.6
Conditioned reinforcement - actives0.50.52.2-1.0-1.30.1-1.50.40.3-0.1-0.7-0.60.60.20.10.1
Conditioned reinforcement - inactives0.10.20.50.70.6-0.60.5-0.1-0.10.30.30.3-0.30.2-0.3-0.3
Conditioned locomotion0.50.61.6-0.1-1.30.1-1.20.50.6-0.2-0.3-1.21.2-0.50.7-0.1
Intermittent access intake day 1-15 change0.60.61.40.1-1.10.4-1.20.80.7-0.90.4-0.70.70.20.80.9
Intermittent access intake escalation0.80.81.70.2-1.20.6-1.30.90.8-0.90.5-0.90.90.21.01.0
Intermittent access intake escalation 20.60.51.40.4-0.80.6-0.80.70.7-0.90.3-0.80.8-0.10.91.2
Intermitt. access day 1 inactive lever presses0.00.00.10.1-0.10.4-0.20.10.10.30.1-0.00.00.20.2-0.1
Intermitt. access day 15 inactive lever presses1.21.34.50.82.1-0.81.9-0.8-0.80.80.21.4-1.4-0.3-1.3-0.7
Intermitt. access escalation Index0.10.10.4-0.6-0.40.2-0.30.00.00.0-0.60.2-0.20.1-0.00.1
Intermittent access day 1 total infusions1.31.45.31.60.80.80.91.11.2-1.01.4-1.01.0-2.30.61.0
Intermittent access day 15 total infusions1.92.13.01.3-0.51.3-0.51.71.7-1.71.5-1.61.6-1.71.41.7
Intermittent access terminal intake (last 3 days)1.21.33.41.40.30.80.31.31.2-1.31.3-1.01.0-1.90.91.3
Intermittent access total infusions2.02.26.21.90.61.20.61.61.6-1.41.6-1.31.3-2.51.11.4
Intermittent access day 1 locomotion1.01.04.41.20.90.21.10.80.9-0.60.9-1.01.0-2.10.40.6
Intermittent access day 15 total locomotion2.02.13.11.3-0.51.2-0.41.61.7-1.61.2-1.81.8-1.61.61.7
Intermittent access total locomotion1.61.84.71.60.40.80.51.41.6-1.21.3-1.61.6-2.21.21.2
Intermittent access standard deviation0.10.10.30.1-0.60.1-0.50.20.3-0.20.3-0.40.4-0.00.40.2
Cocaine induced anxiety0.30.30.7-0.10.8-0.60.7-0.5-0.60.4-0.40.7-0.7-0.1-0.80.0
Post-drug Anxiety1.41.65.91.91.60.51.70.60.9-0.31.6-0.50.5-2.40.30.7
Baseline Anxiety0.91.04.11.31.8-0.22.0-0.00.30.61.0-0.10.1-1.5-0.1-0.7
Lifetime Intake1.21.34.91.71.00.71.01.11.1-0.91.3-0.80.8-2.20.60.8
Incentive Sensitization - Responses1.41.42.21.4-0.11.3-0.01.21.3-1.11.4-1.31.3-1.51.21.3
Incentive Sensitization - Breakpoint1.51.52.01.3-0.11.4-0.11.21.3-1.21.3-1.31.3-1.41.21.4
Progressive ratio test 1 active lever presses0.40.40.80.2-0.50.2-0.70.80.7-0.90.0-0.80.8-0.60.50.7
Progressive ratio test 1 breakpoint0.90.91.70.6-0.70.6-0.81.21.1-1.30.5-1.11.1-0.80.91.0
Progressive ratio test 1 inactive lever presses0.20.20.40.2-0.30.5-0.50.70.5-0.50.2-0.20.2-0.10.30.6
Progressive ratio test 2 active lever presses1.81.92.80.7-1.11.2-1.21.61.6-1.50.5-1.71.7-1.31.51.6
Progressive ratio test 2 breakpoint2.42.74.01.2-1.01.6-1.01.91.9-1.71.0-2.02.0-1.61.81.9
Progressive ratio test 2 inactive lever presses0.70.81.60.2-1.10.9-1.31.00.9-0.80.4-1.01.0-0.40.91.1
Total sessions with >9 infusions0.00.00.20.10.1-0.10.10.10.00.1-0.5-0.10.1-0.4-0.0-0.0
Short access day 1 total inactive lever presses0.10.10.30.1-0.20.2-0.20.50.5-0.3-0.1-0.50.5-0.30.50.2
Short access day 10 total inactive lever presses0.50.51.00.6-0.71.0-0.80.60.6-0.60.8-0.70.7-0.31.00.9
Short access day 1 total infusions0.50.52.20.71.5-0.51.5-0.2-0.30.50.10.4-0.4-0.3-0.5-0.5
Short access day 10 total infusions0.60.62.30.80.90.40.90.80.7-0.90.7-0.30.3-1.50.20.7
Short access total infusions0.50.61.81.11.30.11.20.40.3-0.10.9-0.00.0-1.4-0.1-0.0
Short access day 1 locomotion0.40.51.41.00.90.11.00.60.7-0.20.6-0.50.5-1.20.40.2
Short access day 10 total locomotion0.40.41.1-1.00.5-0.90.6-0.4-0.40.6-1.00.5-0.50.0-0.7-0.7
Short access total locomotion0.30.31.30.70.8-0.10.90.50.6-0.30.4-0.40.4-1.10.20.2
Compulsive drug intake0.60.61.51.21.10.71.10.40.50.00.9-0.30.3-1.20.30.3
One hour access (0.3 mA shock)2.83.27.02.10.01.8-0.02.02.1-1.62.0-1.81.8-2.61.71.6
One hour access (shock baseline)1.01.21.80.7-0.81.0-0.91.31.3-1.30.7-1.31.3-1.01.21.1
Number of responses in last shaping day0.10.10.4-0.3-0.3-0.0-0.30.10.1-0.3-0.7-0.10.10.2-0.20.4
Context. condit. distance diff. score1.21.53.5-1.6-0.3-1.2-0.4-1.3-1.51.1-1.91.0-1.01.4-1.2-1.0
Locomotion velocity, session 11.11.21.90.6-0.71.2-0.51.11.3-1.10.8-1.41.4-1.21.41.1
Locomotion distance, session 11.52.03.60.9-0.81.6-0.51.51.5-1.91.3-1.51.5-1.01.71.8
Locomotion velocity, session 21.72.02.90.1-1.61.7-1.41.51.7-1.40.4-1.71.7-0.71.71.4
Locomotion distance, session 23.04.36.50.6-2.12.5-1.82.32.4-2.61.3-2.32.3-0.82.52.4
Locomotion velocity, session 30.60.71.3-0.60.2-0.90.3-1.0-0.91.0-0.81.1-1.11.1-0.8-0.9
Locomotion distance, session 30.10.10.30.2-0.20.3-0.10.20.2-0.40.3-0.10.10.10.40.5
Stereotopy head waving bouts, day 31.31.63.30.0-1.81.6-1.81.21.0-1.30.3-1.21.2-0.41.51.2
Stereotopy head waving duration, day 30.10.10.20.3-0.20.5-0.20.30.3-0.30.2-0.30.3-0.40.40.2
Locomotion velocity, session 70.10.10.60.30.6-0.10.8-0.3-0.10.20.50.4-0.4-0.0-0.1-0.1
Locomotion distance, session 70.00.00.20.30.30.10.40.00.0-0.10.4-0.00.0-0.10.10.1
Stereotopy head waving bouts, day 72.02.24.01.90.41.50.51.61.7-1.62.0-1.01.0-2.01.51.6
Stereotopy head waving duration, day 70.81.01.91.10.21.00.41.11.3-1.11.2-0.60.6-1.41.01.1
Locomotion velocity, session 81.01.11.90.4-0.81.2-0.71.21.2-1.40.6-1.21.2-0.91.21.4
Locomotion distance, session 80.60.93.1-1.3-1.80.6-1.70.40.2-0.8-0.9-0.60.60.70.60.8
Degree of sensitization distance0.30.30.80.60.20.50.30.50.6-0.40.6-0.60.6-0.90.40.3
Degree of sensitization stereotypy0.70.71.91.20.80.60.90.81.0-0.71.2-0.30.3-1.40.60.8
Condit. Reinf. active minus inactive responses0.91.02.5-1.2-0.3-0.9-0.2-1.1-1.10.9-1.30.9-0.91.6-0.9-0.7
Condit. Reinf. active-inactive response ratio1.31.42.1-0.90.4-1.30.4-1.5-1.41.4-1.21.2-1.21.4-1.3-1.2
Condit. Reinf. active responses0.10.10.6-0.3-0.3-0.1-0.2-0.3-0.30.2-0.40.2-0.20.8-0.1-0.2
Condit. Reinf. inactive responses0.50.61.11.10.10.90.10.90.9-0.81.1-0.70.7-0.90.90.7
Incentive salience index mean0.20.30.6-0.3-0.0-0.50.1-0.7-0.70.6-0.60.5-0.50.8-0.5-0.5
Condit. Reinf. lever presses0.10.20.70.80.7-0.10.6-0.1-0.20.30.50.1-0.1-0.4-0.0-0.3
Time in familiar zone, hab. session 10.30.30.7-0.7-0.0-0.40.1-0.5-0.50.3-0.70.9-0.90.6-0.4-0.4
Time in novel zone, hab. session 10.20.20.5-0.6-0.6-0.1-0.6-0.2-0.10.2-0.5-0.20.20.7-0.1-0.1
Total zone transitions, hab. session 13.34.76.91.2-1.52.6-1.12.32.4-2.51.9-2.52.5-1.92.62.4
Total locomotion distance, hab. session 10.71.02.11.2-0.11.10.20.90.9-1.11.4-0.90.9-1.01.11.0
Locomotion velocity, hab. session 11.21.74.22.00.71.11.01.01.1-1.22.1-1.11.1-1.81.11.1
Time in familiar zone, hab. session 22.52.64.2-1.60.7-1.80.7-1.7-1.61.5-1.72.1-2.11.7-1.8-1.5
Time in novel zone, hab. session 21.51.52.61.5-0.01.2-0.01.21.2-1.01.5-1.61.6-1.61.21.0
Total zone transitions, hab. session 24.15.37.50.8-2.02.6-1.82.52.5-2.71.5-2.72.7-1.52.72.6
Total locomotion distance, hab. session 22.43.24.51.7-0.41.9-0.31.91.9-2.12.1-1.81.8-1.82.02.1
Locomotion velocity, hab. session 22.63.54.81.8-0.52.0-0.32.02.0-2.22.2-1.91.9-1.82.12.1
Novel to familiar place preference ratio0.20.30.50.40.30.40.30.60.7-0.40.5-0.70.7-0.70.40.3
Novelty place preference0.10.10.30.10.40.20.40.30.5-0.10.2-0.30.3-0.50.10.1
Time in novel zone, NPP test0.00.00.1-0.20.20.10.30.20.4-0.1-0.1-0.20.2-0.3-0.00.1
Total zone transitions, NPP test1.82.53.50.2-1.71.9-1.61.71.6-1.90.8-1.81.8-0.71.91.8
Total locomotion distance, NPP test1.21.62.91.6-0.01.40.11.31.3-1.51.7-1.21.2-1.41.41.3
Locomotion velocity, NPP test1.92.74.52.0-0.21.7-0.21.71.7-1.92.1-1.61.6-1.71.81.7
Pavlov. Cond. lever latency2.73.47.5-2.7-0.9-1.6-0.9-1.8-1.71.6-2.61.5-1.52.7-1.6-1.6
Pavlov. Cond. magazine entry latency2.33.04.01.3-1.02.0-1.22.01.8-2.01.6-1.91.9-1.51.92.0
Pavlov. Cond. change in total contacts0.30.41.11.00.30.50.40.50.5-0.40.9-0.50.5-0.90.60.4
Pavlov. Cond. index score1.51.93.11.70.11.5-0.11.51.4-1.41.8-1.31.3-1.81.41.4
Pavlov. Cond. latency score2.12.74.32.10.01.7-0.11.81.7-1.72.1-1.61.6-2.01.71.7
Pavlov. Cond. lever contacts2.32.87.72.81.11.31.11.41.4-1.12.5-1.21.2-2.51.41.2
Pavlov. Cond. magazine entry number1.21.42.0-0.70.8-1.40.9-1.4-1.31.4-0.91.4-1.41.1-1.3-1.4
Pavlov. Cond. intertrial magazine entries0.10.20.5-0.20.1-0.40.2-0.5-0.40.3-0.20.5-0.50.7-0.3-0.4
Pavlov. Cond. lever-magazine prob. diff.1.21.63.01.60.21.30.11.31.2-1.21.6-1.21.2-1.71.21.2
Pavlov. Cond. response bias1.41.72.81.5-0.11.3-0.31.41.3-1.31.5-1.41.4-1.71.31.3
Bone: apparent density4.16.816.9-3.8-1.8-1.9-2.0-2.3-2.71.9-3.72.2-2.24.1-2.0-1.9
Bone surface3.46.116.1-3.9-2.3-1.3-2.4-1.9-2.31.4-3.61.8-1.84.0-1.5-1.4
Bone volume4.67.817.4-3.7-1.1-2.3-1.2-2.7-3.12.2-3.72.8-2.84.2-2.4-2.2
Bone: connectivity density3.45.315.8-4.0-3.1-0.7-3.2-1.3-1.70.8-3.50.9-0.93.6-0.9-0.8
Bone: cortical apparent density0.40.51.0-0.40.7-0.80.7-0.7-0.70.8-0.51.0-1.00.4-0.8-0.9
Bone: cortical area1.52.35.8-2.2-0.9-1.0-1.0-1.3-1.61.0-2.11.3-1.32.4-1.1-1.0
Bone: cortical porosity1.21.32.61.3-0.11.1-0.11.41.3-1.21.4-1.01.0-1.61.21.2
Bone: cortical porosity1.31.42.91.3-0.01.10.01.41.4-1.21.5-1.01.0-1.71.21.3
Bone: cortical thickness1.22.04.7-1.9-0.7-1.0-0.9-1.2-1.51.1-1.91.4-1.42.2-1.0-1.0
Bone: cortical thickness0.40.51.00.4-0.90.8-1.00.70.6-0.80.7-0.50.50.20.70.9
Bone: cortical tissue density0.40.50.9-0.30.8-0.70.7-0.7-0.60.8-0.40.9-0.90.3-0.8-0.9
Bone: elastic displacement1.71.93.21.0-0.81.5-0.81.51.5-1.51.2-1.81.8-1.31.51.5
Bone: elastic work1.11.45.6-1.2-2.20.7-2.40.50.3-0.7-0.8-1.01.01.10.70.7
Bone: endosteal estimation0.51.13.6-1.2-1.90.8-1.90.60.4-0.9-0.7-0.60.60.80.70.9
Bone: endosteal perimeter0.40.82.5-1.4-1.3-0.1-1.4-0.3-0.60.0-1.20.2-0.21.6-0.1-0.0
Bone: final force0.61.03.8-1.2-1.90.4-1.90.0-0.2-0.2-0.9-0.00.01.50.30.3
Bone: final moment0.50.93.5-1.1-1.80.4-1.90.0-0.2-0.3-0.9-0.10.11.50.30.4
Bone: marrow area0.51.13.6-1.1-1.90.8-1.90.60.5-1.0-0.6-0.70.70.80.70.9
Bone: maximum diameter0.71.33.9-1.8-1.2-0.4-1.3-0.7-1.00.4-1.60.8-0.82.0-0.5-0.4
Bone: maximum force0.81.34.2-1.7-1.8-0.0-1.8-0.5-0.80.1-1.40.5-0.52.1-0.1-0.0
Bone: maximum moment0.71.24.2-1.6-1.70.0-1.8-0.4-0.70.1-1.40.5-0.52.0-0.10.0
Bone: minimum diameter0.00.00.1-0.2-0.10.2-0.0-0.1-0.0-0.2-0.10.3-0.30.2-0.00.3
Bone: periosteal estimation0.61.33.7-1.9-1.80.1-1.9-0.3-0.5-0.2-1.60.3-0.31.8-0.00.2
Bone: periosteal perimeter1.11.85.2-2.0-0.9-0.9-0.9-1.2-1.40.9-1.91.2-1.22.3-0.9-0.9
Bone: post-yield work0.20.31.0-0.5-0.0-0.3-0.1-0.5-0.80.3-0.51.0-1.00.7-0.5-0.2
Bone: stiffness0.30.51.5-1.1-0.8-0.2-0.8-0.5-0.60.4-0.90.8-0.81.2-0.2-0.3
Bone: tissue strength0.50.52.2-1.5-0.7-0.3-0.6-0.5-0.50.3-1.30.3-0.30.8-0.3-0.2
Bone: trabecular number3.25.012.9-3.6-2.3-1.3-2.4-1.7-2.01.2-3.31.6-1.63.6-1.3-1.3
Bone: trabecular spacing0.60.73.50.91.7-0.31.9-0.20.00.40.80.1-0.1-1.0-0.4-0.4
Bone: trabecular thickness3.13.78.3-2.5-1.0-1.6-1.2-1.8-2.11.5-2.61.8-1.82.9-1.7-1.5
Bone: trabecular tissue density1.42.03.5-0.71.3-1.51.4-1.4-1.31.7-0.91.9-1.90.8-1.5-1.7
Breakpoint value in progressive ratio session0.20.20.50.4-0.00.2-0.00.30.4-0.60.4-0.70.7-0.70.20.4
Distance traveled before self-admin0.90.92.20.31.5-0.71.5-1.0-0.81.2-0.20.8-0.80.0-1.2-1.1
Distance traveled after self-admin0.10.10.70.0-0.3-0.1-0.30.0-0.1-0.20.10.2-0.20.80.10.1
Delta time in closed arm before/after self-admin0.30.31.5-1.2-0.2-0.5-0.4-0.2-0.20.2-1.00.5-0.50.1-0.7-0.3
Delta time in open arm before/after self-admin1.81.76.62.62.00.12.20.40.5-0.22.0-0.20.2-1.40.20.1
Diff in mean of infusions in LGA sessions0.10.20.50.70.70.20.7-0.3-0.10.00.3-0.10.1-0.5-0.40.1
Extinction: sum of active levers before priming0.90.91.6-0.60.6-1.10.7-1.2-1.21.1-0.90.7-0.71.2-1.0-1.2
Active lever presses in extinction session 62.62.55.0-2.10.2-1.70.1-1.5-1.61.3-1.81.6-1.62.2-1.5-1.6
Delta distance traveled before/after self-admin1.71.83.60.0-1.91.3-1.81.41.2-1.70.3-1.21.20.31.71.6
Delta ambulatory time before/after self-admin0.90.92.00.0-1.40.8-1.31.00.8-1.40.4-0.70.70.51.31.2
Time in closed arm before self-admin0.91.03.1-1.4-1.80.5-1.70.50.4-0.5-0.8-1.21.20.30.60.3
Time in closed arm after self-admin2.02.08.7-2.9-2.30.2-2.30.40.3-0.6-2.1-0.80.80.80.20.4
Time in open arm before self-admin0.30.41.2-1.1-0.40.4-0.6-0.2-0.4-0.2-0.60.7-0.71.0-0.40.2
Time in open arm after self-admin0.80.83.81.91.40.11.40.10.10.01.60.4-0.4-0.70.00.1
Sum of active levers in priming session hrs 5-60.10.10.3-0.10.2-0.40.4-0.4-0.50.3-0.20.0-0.00.5-0.2-0.4
Time to tail flick, vehicle, before self-admin0.20.20.60.60.3-0.30.4-0.20.00.70.7-0.30.3-0.5-0.1-0.6
Time to tail flick, vehicle, after self-admin0.20.31.4-1.2-0.4-0.1-0.1-0.4-0.40.3-0.6-0.00.00.9-0.1-0.4
Time to tail flick, test, before self-admin1.01.04.1-2.0-1.1-0.4-1.0-0.6-0.70.4-1.60.5-0.51.4-0.4-0.3
Time to tail flick, test, after self-admin0.70.72.2-1.10.2-1.10.2-0.8-0.90.7-1.50.5-0.50.7-0.8-0.9
Delta time to tail flick, vehicle, before/after SA0.80.81.5-1.20.4-0.60.6-0.9-1.00.4-1.11.0-1.01.2-0.8-0.6
Delta time to tail flick, test, before/after SA0.20.20.60.80.6-0.10.60.20.2-0.20.4-0.30.3-0.50.10.0
Ambulatory time before self-admin0.30.30.90.40.9-0.30.9-0.5-0.40.7-0.10.4-0.4-0.0-0.6-0.6
Ambulatory time after self-admin0.00.00.3-0.0-0.3-0.1-0.30.10.0-0.20.10.0-0.00.60.10.1
Total heroin consumption1.01.25.01.62.1-0.22.2-0.00.20.20.90.2-0.2-1.3-0.2-0.4
Area under the delay curve0.60.71.81.30.50.60.70.60.7-0.61.1-0.80.8-1.00.80.6
Delay disc. indifference point, 0s delay0.20.20.8-0.50.0-0.20.2-0.4-0.40.4-0.70.2-0.20.9-0.2-0.2
Delay disc. indifference point, 16s delay0.40.41.61.11.2-0.21.3-0.10.00.20.60.2-0.2-0.8-0.1-0.2
Delay disc. indifference point, 2s delay0.40.51.31.11.00.11.20.40.5-0.60.8-0.30.3-0.90.40.4
Delay disc. indifference point, 24s delay0.40.41.10.90.60.50.80.30.5-0.21.1-0.30.3-0.70.40.3
Delay disc. indifference point, 4s delay0.50.62.11.40.90.41.10.20.3-0.10.9-0.50.5-1.00.60.3
Delay disc. indifference point, 8s delay0.30.40.90.90.00.60.10.60.5-0.60.7-0.70.7-0.50.70.5
Delay discount exponential model param0.70.82.4-1.6-0.7-0.6-0.9-0.6-0.70.5-1.20.8-0.81.2-0.8-0.5
Delay discount hyperbolic model param0.80.82.4-1.5-0.7-0.6-0.9-0.7-0.80.6-1.20.8-0.81.2-0.9-0.6
Fecal boli incidents, locomotor time 10.60.62.4-1.5-1.3-0.2-1.1-0.4-0.20.2-1.50.1-0.10.8-0.1-0.2
Change in fecal boli incidents, locomotor task0.40.41.51.01.2-0.21.10.0-0.00.40.80.2-0.2-0.8-0.2-0.1
Time >=10cm from walls, locomotor time 10.50.51.30.01.1-0.51.1-0.5-0.70.6-0.30.9-0.90.2-0.8-0.6
Bouts of movement, locomotor time 10.20.20.80.3-0.70.3-0.90.20.1-0.20.1-0.40.40.10.50.2
Total resting periods, locomotor time 10.10.10.50.4-0.60.2-0.70.0-0.0-0.00.2-0.20.20.10.3-0.0
Rest time, locomotor task time 10.70.81.61.0-0.70.9-0.70.80.9-0.71.3-0.70.7-1.01.00.8
Distance moved, locomotor task time 10.20.21.0-1.0-0.2-0.2-0.2-0.1-0.2-0.0-0.80.3-0.30.7-0.30.0
Vertical activity count, locomotor time 10.60.61.8-1.3-0.6-0.7-0.7-0.4-0.60.3-1.30.4-0.41.2-0.4-0.3
Time >=10cm from walls, locomotor time 20.80.92.2-1.2-0.4-0.9-0.4-0.8-0.90.8-1.30.9-0.91.5-0.6-0.8
Bouts of movement, locomotor time 21.31.44.8-2.0-1.3-0.7-1.5-0.6-0.90.5-1.40.6-0.62.2-0.5-0.7
Total resting periods, locomotor time 21.41.54.8-1.9-1.0-1.0-1.1-0.9-1.20.8-1.30.9-0.92.2-0.8-1.1
Rest time, locomotor task time 20.30.41.51.20.80.20.70.00.00.01.20.0-0.0-0.70.20.1
Distance moved, locomotor task time 20.60.72.5-1.1-1.60.0-1.50.50.4-0.6-0.9-0.60.60.80.60.4
Vertical activity count, locomotor time 21.01.13.7-1.6-1.9-0.3-1.90.0-0.1-0.0-1.4-0.20.21.30.2-0.1
Weight adjusted by age1.61.86.1-1.2-2.51.0-2.30.80.7-1.4-0.3-0.80.81.31.31.4
Seeking ratio, delayed vs. immediate footshock0.50.62.01.31.4-0.41.4-0.10.10.50.6-0.00.0-1.2-0.2-0.4
Locomotion in novel chamber3.74.67.01.1-1.72.2-1.82.62.5-2.31.7-2.42.4-1.62.52.5
Locomotion in novel chamber post-restriction4.25.07.80.4-2.52.8-2.72.42.2-2.41.1-2.62.6-0.82.52.5
Progressive ratio0.30.30.91.00.90.80.90.50.5-0.10.50.0-0.0-0.60.20.3
Food seeking constrained by brief footshock0.10.10.8-0.6-0.1-0.4-0.2-0.2-0.30.1-0.90.4-0.40.1-0.3-0.1
Seeking ratio, punishment vs. effort0.50.62.2-1.4-1.5-0.5-1.5-0.2-0.2-0.1-1.1-0.30.30.50.0-0.0
Run reversals in cocaine runway, females0.50.51.41.20.80.60.90.60.6-0.61.1-0.20.2-0.90.40.5
Run reversals in cocaine runway, males0.60.61.9-1.4-0.5-1.0-0.6-0.6-0.70.2-0.80.6-0.61.2-0.8-0.5
Latency to leave start box in cocaine runway3.13.45.4-1.01.6-2.31.4-2.0-1.81.9-0.72.3-2.31.4-2.3-2.1
Latency to leave start box in cocaine runway, F4.44.88.8-1.41.6-3.01.5-2.4-2.22.4-1.42.5-2.51.4-2.7-2.7
Latency to leave start box in cocaine runway, M0.30.30.70.2-0.30.8-0.40.50.5-0.80.9-0.30.30.40.50.8
Cd content in liver0.70.71.61.00.10.70.20.81.0-0.71.0-1.11.1-1.30.80.7
Co content in liver2.02.34.02.00.01.5-0.11.71.6-1.52.0-1.61.6-1.81.51.5
Cu content in liver1.61.93.8-1.8-0.3-1.4-0.3-1.4-1.41.3-1.91.3-1.32.0-1.2-1.2
Fe content in liver8.410.017.4-3.6-0.5-3.2-0.7-3.4-3.53.2-3.93.0-3.04.2-3.2-3.2
K content in liver0.50.50.80.90.00.80.10.70.6-0.70.9-0.70.7-0.80.80.7
Mg content in liver0.50.51.01.0-0.00.70.00.70.8-0.70.9-0.70.7-0.80.80.6
Mn content in liver0.20.20.4-0.6-0.60.5-0.20.40.5-0.6-0.2-0.40.4-0.20.50.5
Na content in liver0.00.00.2-0.4-0.40.1-0.3-0.1-0.10.1-0.30.0-0.00.20.1-0.0
Rb content in liver1.21.54.40.72.0-1.12.1-1.0-0.91.20.21.1-1.1-0.6-1.0-1.1
Se content in liver2.63.14.5-1.21.0-2.10.9-2.0-2.12.0-1.52.0-2.01.3-2.0-2.1
Sr content in liver0.80.71.7-0.3-1.31.0-1.30.70.6-0.8-0.0-0.90.90.10.80.8
Zn content in liver1.51.74.7-2.1-1.6-0.7-1.7-0.7-0.80.7-2.00.4-0.42.2-0.6-0.7