Prkca

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000003491	0.23	0.1	0.0e+00	0.12	0.13	0.12	0.12	1.4e-13	1.4e-14	3.6e-13	4.2e-13
2	Brain	gene expression	ENSRNOG00000003491	0.12	0.06	3.2e-08	0.08	0	0.08	-0	4.3e-08	2.4e-01	1.3e-07	7.1e-01
3	Liver	alternative TSS	ENSRNOT00000112512	0.03	0.02	5.6e-03	0.02	0.01	-0	0.01	2.4e-03	9.7e-03	7.4e-01	1.3e-02
4	Liver	gene expression	ENSRNOG00000003491	0.65	0.32	0.0e+00	0.15	0.26	0.25	0.26	8.3e-17	3.4e-28	5.2e-28	2.0e-28
5	NAcc	isoform ratio	ENSRNOT00000055073	0.03	0.02	6.9e-03	0.04	0.02	0.03	0.03	6.5e-04	6.9e-03	3.6e-03	2.0e-03
6	OFC	mRNA stability	ENSRNOG00000003491	0.19	0.11	7.1e-03	0.03	0.05	0.05	0.08	8.5e-02	3.1e-02	2.5e-02	5.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
BMI with tail	3.4	11.1	31.7	0.7	-5.6	-4.5	-2.0	-0.1	3.2
BMI without tail	2.3	4.8	13.2	1.0	-3.6	-2.5	-0.5	-1.7	2.3
Body weight	3.3	14.0	34.4	3.2	-5.9	-2.7	0.9	-2.2	5.1
Epididymis fat weight	3.3	7.6	22.8	1.6	-4.8	-2.8	-0.4	-0.2	3.4
Glucose	0.4	0.6	3.0	-0.5	-0.2	-0.4	-0.7	1.7	-0.2
Heart weight	1.6	2.3	7.1	1.8	-1.5	0.4	0.8	-0.3	2.7
Left kidney weight	0.7	2.1	5.5	0.5	-2.3	-1.4	-0.9	0.3	2.0
Right kidney weight	1.1	3.0	8.0	1.5	-2.6	-0.8	0.1	-0.2	2.8
Tail length	1.1	3.5	6.2	2.2	-0.5	1.3	2.1	-2.5	1.8
Length with tail	1.7	6.2	10.3	3.2	-1.5	1.2	2.8	-2.3	3.2
Length without tail	0.4	0.9	2.4	1.1	-1.2	-0.0	0.7	0.1	1.6
Liver weight, left	0.5	0.7	2.0	-0.6	1.4	0.6	0.1	0.2	-1.3
Liver weight, right	0.6	1.0	2.1	-1.3	0.6	-0.5	-1.1	0.6	-1.4
Parametrial fat weight	0.7	1.3	3.3	-0.2	1.8	1.2	0.5	-0.8	-1.5
Retroperitoneal fat weight	2.9	9.6	24.6	2.3	-5.0	-2.7	0.3	-1.4	4.2
Intraocular pressure	0.2	0.3	0.8	0.1	-0.9	-0.8	-0.2	-0.3	0.5
Extensor digitorum longus weight	1.7	6.7	12.4	-0.6	-3.5	-3.1	-2.4	3.2	1.4
Soleus weight	0.4	1.1	2.6	0.8	-1.5	-0.5	0.1	0.9	1.6
Tibialis anterior weight	1.0	3.3	10.1	0.7	-3.2	-2.2	-0.8	0.4	1.9
Tibia length	0.6	1.8	4.9	1.6	-1.5	0.0	1.1	-0.6	2.2
Number of licking bursts	0.4	0.5	1.1	0.9	-0.2	0.6	0.7	-0.4	1.1
Food consumed during 24 hour testing period	1.4	1.7	5.0	-0.2	-2.0	-2.2	-0.6	-1.0	0.2
Times rat made contact with spout	0.7	0.8	1.6	0.8	-0.8	-0.3	0.8	-0.9	1.3
Mean time between licks in bursts	1.2	1.7	4.2	1.4	-2.1	-0.6	0.6	0.1	1.8
Mean num. licks in bursts	0.2	0.2	0.7	-0.4	-0.4	-0.8	-0.3	-0.0	-0.2
Std. dev. time between licks in bursts	0.9	1.1	2.4	-0.8	-1.1	-1.5	-1.1	0.4	-0.9
Water consumed over 24 hours	1.1	1.3	4.3	-0.7	-1.4	-2.1	-0.8	-0.4	-0.2
Indifference point 0 sec	4.4	7.2	15.5	3.0	-1.7	0.6	2.6	-3.9	2.9
Indifference point AUC	0.6	0.8	2.6	0.9	-0.1	0.5	0.6	-1.6	0.8
Indifference point function ln k	0.7	1.0	1.8	-1.1	1.0	0.1	-1.0	0.9	-1.4
Indifference point function log k	0.7	1.0	1.8	-1.1	1.0	0.1	-1.0	0.9	-1.4
Delay discounting total patch changes 0 sec	4.2	6.8	15.5	2.9	-1.6	0.6	2.5	-3.9	2.7
Delay discounting total patch changes 12 sec	4.4	5.8	13.5	2.8	-0.6	1.2	2.5	-3.7	2.3
Delay discounting total patch changes 18 sec	2.0	2.7	5.4	1.7	-1.7	-0.4	1.1	-2.3	1.9
Delay discounting total patch changes 24 sec	3.5	4.4	8.0	2.5	-1.5	0.5	1.8	-2.8	2.6
Delay discounting total patch changes 6 sec	5.7	8.7	14.4	3.5	-2.0	0.8	2.8	-3.8	3.6
Delay discounting time to switch 0 sec	0.1	0.2	0.4	0.1	-0.6	-0.3	-0.1	0.6	0.4
Delay discounting water rate 0 sec	0.8	1.2	3.3	1.2	-0.1	0.8	1.0	-1.8	1.0
Delay discounting water rate 12 sec	0.2	0.3	0.8	-0.1	-0.9	-0.6	-0.4	0.6	0.4
Delay discounting water rate 18 sec	0.3	0.4	0.9	-0.8	-0.3	-0.9	-0.6	0.2	-0.5
Delay discounting water rate 24 sec	0.7	0.9	1.6	-1.1	0.7	-0.1	-0.8	1.2	-1.3
Delay discounting water rate 6 sec	0.6	0.9	2.2	-1.2	0.3	-0.7	-1.5	0.5	-1.1
Locomotor activity	1.2	1.9	4.2	1.0	-2.0	-1.0	0.6	-1.5	1.6
Locomotor testing distance	0.8	1.3	3.3	0.6	-1.8	-1.3	0.3	-1.0	1.2
Locomotor testing rearing	0.9	1.5	4.5	0.3	-2.1	-1.6	-0.1	-0.6	1.1
Light reinforcement 1	1.2	2.1	4.7	-1.3	-1.1	-2.2	-2.1	-0.4	-0.8
Light reinforcement 2	0.3	0.4	1.5	-0.5	-0.2	-0.5	-1.2	0.6	-0.2
Reaction time number correct	0.6	0.8	1.5	-1.0	1.2	0.4	-0.5	0.9	-1.2
Reaction time mean minus median	0.0	0.1	0.2	0.2	-0.0	0.2	0.1	0.5	-0.0
Reaction time mean minus median AUC	0.4	0.5	1.4	0.0	1.2	1.0	0.5	0.1	-0.7
Reaction time num false alarms	1.3	1.8	3.3	1.6	-1.2	0.2	1.4	-1.2	1.8
Reaction time num false alarms AUC	1.7	2.3	3.5	1.8	-0.9	0.6	1.8	-1.7	1.9
Reaction time trials correct on left	0.6	0.8	1.5	-1.0	1.2	0.4	-0.5	0.9	-1.2
Reaction time trials on left	0.5	0.8	1.5	-0.9	1.2	0.5	-0.4	0.8	-1.2
Reaction time mean	0.6	0.9	2.5	-0.1	1.6	1.3	0.5	-0.3	-0.9
Reaction time mean AUC	0.5	0.7	2.1	-0.3	1.4	1.0	0.3	-0.2	-1.0
Median of all reaction times	0.8	1.1	3.1	-0.2	1.8	1.4	0.5	-0.5	-1.1
Reaction time omissions	0.4	0.5	1.2	0.7	0.2	0.6	0.8	-1.1	0.4
Reaction time false alarm rate	1.8	2.6	4.9	1.9	-1.5	0.2	1.6	-1.5	2.2
Reaction time premature initiation rate	1.4	1.8	4.3	1.5	-1.6	-0.2	0.7	-1.2	2.1
Reaction time premature initiations	0.3	0.4	0.9	0.8	-0.5	0.2	0.4	-0.7	1.0
Std. dev. reaction times	0.4	0.5	1.3	0.3	1.0	1.1	0.8	-0.2	-0.4
Reaction time trials completed	0.5	0.8	1.5	-0.9	1.2	0.5	-0.4	0.8	-1.2
Reaction time trials AUC	0.6	0.8	1.6	-1.0	1.2	0.5	-0.4	0.8	-1.3
Social response proportion	0.6	0.6	1.6	0.7	-0.0	0.6	0.8	-1.3	0.6
Social responses	1.9	2.5	5.7	1.6	-1.4	-0.1	1.3	-2.4	1.7
Social time	0.2	0.3	0.5	0.7	0.0	0.7	0.6	-0.1	0.6
Conditioned locomotion	0.1	0.1	0.3	-0.3	0.5	0.2	-0.2	-0.1	-0.4
Cocaine response after cond. corrected	0.3	0.3	0.7	0.6	0.3	0.8	0.5	-0.2	0.7
Cocaine response after cond. not corrected	0.4	0.4	0.9	0.6	0.4	0.9	0.6	0.1	0.8
Cocaine response before conditioning	0.1	0.1	0.3	-0.2	0.4	0.2	0.1	0.5	-0.4
Saline control response	1.7	2.2	6.5	0.2	-2.5	-2.2	-0.7	-0.6	1.1
Condit. Reinf. active minus inactive responses	4.2	5.2	8.8	2.5	0.7	2.3	3.0	-2.7	1.8
Condit. Reinf. active-inactive response ratio	4.0	4.2	6.9	2.3	0.7	2.2	2.6	-2.0	1.8
Condit. Reinf. active responses	4.2	5.9	10.3	2.7	0.5	2.1	3.1	-3.2	1.9
Condit. Reinf. inactive responses	0.5	0.6	3.1	0.4	0.1	0.1	0.7	-1.7	-0.0
Condit. Reinf. lever presses	2.6	3.6	7.7	2.2	-0.7	0.8	1.9	-2.8	2.0
Condit. Reinf. lever reinforcers received	4.1	5.8	10.3	2.7	0.3	2.0	3.0	-3.2	2.0
Pavlov. Cond. lever latency	0.8	1.1	1.9	-0.9	-0.8	-1.3	-1.1	1.4	-0.3
Pavlov. Cond. magazine entry latency	0.1	0.2	0.5	-0.3	0.0	-0.2	-0.6	0.7	-0.2
Pavlov. Cond. change in total contacts	0.4	0.6	1.0	0.7	0.5	0.8	1.0	-1.0	0.3
Pavlov. Cond. index score	0.4	0.6	0.9	0.9	0.2	0.8	0.9	-0.8	0.6
Pavlov. Cond. latency score	0.4	0.5	0.7	0.9	0.3	0.9	0.9	-0.7	0.5
Pavlov. Cond. lever contacts	0.5	0.7	2.4	0.7	0.4	0.6	0.7	-1.5	0.2
Pavlov. Cond. magazine entry number	0.3	0.3	0.9	0.4	0.4	0.6	0.7	-0.9	0.1
Pavlov. Cond. intertrial magazine entries	1.4	1.8	5.9	1.2	0.2	0.8	1.6	-2.4	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.7	0.8	0.3	0.8	0.8	-0.7	0.5
Pavlov. Cond. response bias	0.4	0.5	1.6	0.6	0.4	0.7	0.7	-1.3	0.2
Conditioned reinforcement - actives	1.1	1.1	2.6	-0.6	1.6	1.1	0.0	-0.7	-1.4
Conditioned reinforcement - inactives	1.1	1.3	2.6	1.3	-0.6	0.5	1.1	-1.6	1.3
Conditioned locomotion	2.1	2.5	4.8	1.8	-0.0	1.8	1.5	-2.2	1.3
Intermittent access intake day 1-15 change	2.2	2.1	4.6	1.9	-0.8	1.3	1.4	-0.7	2.1
Intermittent access intake escalation	2.2	2.2	4.8	1.9	-0.8	1.3	1.3	-0.7	2.2
Intermittent access intake escalation 2	3.8	3.8	6.0	2.4	-0.7	1.6	2.1	-1.8	2.4
Intermitt. access day 1 inactive lever presses	1.8	2.0	4.0	1.6	-1.2	0.0	1.2	-1.6	2.0
Intermitt. access day 15 inactive lever presses	1.3	1.5	3.4	1.0	-1.8	-0.5	0.3	-0.9	1.8
Intermitt. access escalation Index	0.9	0.8	1.8	-0.7	1.4	0.7	0.0	0.7	-1.2
Intermittent access day 1 total infusions	0.3	0.3	1.8	0.3	-0.2	0.2	0.2	-1.3	0.1
Intermittent access day 15 total infusions	3.0	3.4	5.2	2.2	-1.0	1.5	1.7	-2.0	2.3
Intermittent access terminal intake (last 3 days)	4.1	4.5	7.0	2.5	-0.7	1.8	2.2	-2.7	2.3
Intermittent access total infusions	2.7	2.9	6.9	1.9	-0.6	1.3	1.6	-2.6	1.6
Intermittent access day 1 locomotion	2.8	2.8	4.9	2.0	-1.5	0.6	1.2	-1.9	2.2
Intermittent access day 15 total locomotion	4.5	4.8	7.7	2.7	-1.0	1.6	1.9	-2.8	2.6
Intermittent access total locomotion	6.9	7.7	12.3	3.4	-2.0	1.3	2.4	-3.3	3.5
Intermittent access standard deviation	2.9	3.1	7.1	2.4	-1.2	1.1	1.5	-0.9	2.7
Cocaine induced anxiety	0.4	0.4	1.2	-0.7	0.8	0.2	-0.1	0.4	-1.1
Post-drug Anxiety	1.0	1.1	2.3	-0.9	1.3	0.2	-0.6	1.5	-1.2
Baseline Anxiety	1.5	1.6	2.8	-1.5	0.5	-1.0	-1.7	1.4	-1.3
Lifetime Intake	2.2	2.4	7.1	1.6	-0.6	1.1	1.2	-2.7	1.4
Incentive Sensitization - Responses	0.9	0.9	1.9	0.2	1.4	1.3	0.8	-0.8	-0.6
Incentive Sensitization - Breakpoint	1.0	1.0	2.1	0.2	1.4	1.5	0.8	-0.8	-0.6
Progressive ratio test 1 active lever presses	2.1	2.1	6.0	1.0	-1.7	-0.7	1.0	-2.5	1.2
Progressive ratio test 1 breakpoint	2.1	2.2	6.0	1.2	-1.7	-0.6	1.0	-2.5	1.3
Progressive ratio test 1 inactive lever presses	2.6	2.8	5.8	1.6	-1.8	-0.3	1.1	-2.4	1.9
Progressive ratio test 2 active lever presses	1.5	1.6	4.6	1.1	-0.2	1.0	1.4	-2.1	0.7
Progressive ratio test 2 breakpoint	1.5	1.7	5.0	1.1	-0.0	1.0	1.5	-2.2	0.6
Progressive ratio test 2 inactive lever presses	2.0	2.3	5.3	1.6	0.1	1.5	1.6	-2.3	1.1
Total sessions with >9 infusions	0.2	0.2	1.2	0.2	-0.2	0.1	-0.2	-1.1	0.3
Short access day 1 total inactive lever presses	0.1	0.1	0.4	0.2	-0.3	0.3	-0.0	-0.6	0.4
Short access day 10 total inactive lever presses	0.9	1.0	3.0	1.4	-0.6	0.7	0.6	-0.4	1.7
Short access day 1 total infusions	0.3	0.3	0.8	-0.4	-0.3	-0.3	-0.7	-0.9	-0.3
Short access day 10 total infusions	3.0	3.3	8.3	1.8	-1.8	-0.2	1.0	-2.9	2.0
Short access total infusions	1.2	1.4	5.4	1.0	-0.6	0.5	0.6	-2.3	0.8
Short access day 1 locomotion	1.1	1.2	4.1	0.5	-1.3	-0.7	-0.0	-2.0	0.6
Short access day 10 total locomotion	5.2	5.7	10.3	3.0	-2.0	0.7	2.1	-2.5	3.2
Short access total locomotion	3.3	3.4	5.6	1.9	-2.2	-0.3	0.8	-2.4	2.4
Compulsive drug intake	1.7	1.7	4.1	1.2	1.2	2.0	1.3	-1.0	0.6
One hour access (0.3 mA shock)	3.0	3.5	8.0	1.8	0.4	2.1	1.8	-2.8	1.4
One hour access (shock baseline)	0.5	0.6	1.5	0.8	-0.7	0.3	0.5	-1.2	0.8
Number of responses in last shaping day	0.6	0.6	1.7	0.4	-1.3	-0.7	-0.2	-0.2	1.0
Context. condit. distance diff. score	0.1	0.2	0.4	0.3	-0.6	-0.3	-0.2	-0.2	0.5
Locomotion velocity, session 1	0.0	0.0	0.1	0.1	-0.1	-0.2	0.3	0.1	0.1
Locomotion distance, session 1	0.1	0.1	0.3	-0.2	-0.4	-0.5	-0.2	0.5	-0.0
Locomotion velocity, session 2	0.4	0.4	1.4	-0.9	0.6	-0.3	-0.1	0.1	-1.2
Locomotion distance, session 2	0.5	0.7	1.2	-1.1	0.0	-0.9	-0.7	0.6	-1.1
Locomotion velocity, session 3	1.8	2.0	3.2	-1.7	-0.7	-1.8	-1.7	1.4	-1.0
Locomotion distance, session 3	0.1	0.1	0.2	-0.1	0.3	0.3	0.1	0.5	0.0
Stereotopy head waving bouts, day 3	4.0	4.8	10.5	-2.8	1.5	-0.7	-2.2	1.7	-3.2
Stereotopy head waving duration, day 3	2.1	2.6	5.3	-2.0	1.1	-0.4	-1.6	1.5	-2.3
Locomotion velocity, session 7	0.6	0.7	1.4	-0.9	-0.4	-0.9	-0.9	1.2	-0.5
Locomotion distance, session 7	0.3	0.4	0.9	0.8	-0.1	0.6	0.6	-0.3	0.9
Stereotopy head waving bouts, day 7	2.5	2.8	5.0	-2.2	0.3	-1.3	-1.9	1.6	-2.0
Stereotopy head waving duration, day 7	3.7	4.6	8.1	-2.8	1.2	-1.0	-2.2	2.1	-2.8
Locomotion velocity, session 8	0.0	0.0	0.1	0.1	0.3	0.3	0.4	0.1	-0.1
Locomotion distance, session 8	0.1	0.1	0.2	-0.3	-0.3	-0.5	-0.1	-0.2	-0.2
Degree of sensitization distance	0.3	0.3	0.7	0.6	0.1	0.5	0.5	-0.8	0.4
Degree of sensitization stereotypy	1.7	1.8	2.9	-1.7	-0.3	-1.5	-1.7	1.4	-1.1
Condit. Reinf. active minus inactive responses	3.6	4.0	6.0	2.5	-0.3	1.4	2.4	-2.4	2.2
Condit. Reinf. active-inactive response ratio	1.4	1.5	2.5	1.4	0.5	1.4	1.6	-1.2	0.9
Condit. Reinf. active responses	3.0	3.6	6.2	2.2	-0.4	1.1	2.3	-2.5	2.0
Condit. Reinf. inactive responses	0.4	0.5	1.5	0.6	-0.5	-0.2	0.7	-1.2	0.6
Incentive salience index mean	1.5	1.8	3.1	1.6	-0.4	0.6	1.5	-1.8	1.5
Condit. Reinf. lever presses	0.3	0.4	1.1	-0.0	-1.1	-0.9	-0.4	-0.0	0.6
Time in familiar zone, hab. session 1	2.0	1.9	3.2	1.8	0.0	1.4	1.7	-1.0	1.6
Time in novel zone, hab. session 1	1.3	1.2	2.0	-1.4	-0.1	-1.2	-1.4	0.8	-1.2
Total zone transitions, hab. session 1	0.9	1.3	3.5	-0.1	-1.9	-1.8	-0.5	0.6	0.8
Total locomotion distance, hab. session 1	0.6	0.9	2.9	-0.3	-1.4	-1.7	-0.4	-0.2	0.1
Locomotion velocity, hab. session 1	0.5	0.8	2.7	-0.4	-1.3	-1.6	-0.4	-0.2	0.0
Time in familiar zone, hab. session 2	1.3	1.4	2.1	1.4	-0.2	0.9	1.4	-1.2	1.4
Time in novel zone, hab. session 2	1.7	1.8	4.0	-1.6	1.1	-0.4	-1.2	1.0	-2.0
Total zone transitions, hab. session 2	1.6	2.1	5.6	-0.7	-2.0	-2.4	-1.2	1.0	0.3
Total locomotion distance, hab. session 2	1.3	1.8	5.7	-0.9	-1.7	-2.4	-1.1	0.1	-0.3
Locomotion velocity, hab. session 2	1.4	1.8	5.5	-1.1	-1.5	-2.3	-1.3	0.4	-0.6
Novel to familiar place preference ratio	2.4	2.5	4.3	2.1	-0.3	1.3	1.7	-1.4	2.1
Novelty place preference	1.5	1.6	3.0	1.7	-0.3	0.9	1.3	-1.0	1.7
Time in novel zone, NPP test	1.3	1.4	2.4	1.5	-0.3	0.8	1.3	-1.1	1.5
Total zone transitions, NPP test	1.1	1.6	3.8	-1.2	-1.0	-1.9	-1.4	0.7	-0.8
Total locomotion distance, NPP test	0.9	1.2	3.1	-1.2	-0.5	-1.8	-0.8	-0.6	-1.2
Locomotion velocity, NPP test	0.9	1.3	4.0	-1.1	-1.0	-2.0	-1.1	-0.3	-0.8
Pavlov. Cond. lever latency	1.1	1.4	3.3	-0.8	1.8	1.1	-0.2	0.9	-1.6
Pavlov. Cond. magazine entry latency	1.7	2.2	4.8	1.7	-0.7	0.5	1.5	-2.2	1.6
Pavlov. Cond. change in total contacts	1.6	1.8	3.1	1.3	-1.5	-0.5	0.9	-1.6	1.7
Pavlov. Cond. index score	1.3	1.7	3.1	1.4	-1.2	-0.1	1.0	-1.7	1.7
Pavlov. Cond. latency score	1.4	1.8	3.5	1.4	-1.6	-0.4	0.7	-1.5	1.9
Pavlov. Cond. lever contacts	1.5	1.7	4.8	0.7	-2.2	-1.5	-0.2	-0.4	1.7
Pavlov. Cond. magazine entry number	1.2	1.5	3.4	-1.4	0.2	-0.6	-1.4	1.8	-1.1
Pavlov. Cond. intertrial magazine entries	2.2	2.7	4.7	2.2	-0.8	0.9	1.8	-1.5	2.2
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	2.5	1.2	-1.2	-0.3	0.8	-1.6	1.5
Pavlov. Cond. response bias	0.9	1.0	2.1	1.1	-0.8	-0.0	0.9	-1.5	1.2
Bone: apparent density	0.3	0.5	1.1	0.2	1.1	1.0	0.6	-0.3	-0.4
Bone surface	2.1	3.7	7.2	1.8	1.5	2.6	2.7	-1.5	0.7
Bone volume	1.7	2.9	5.8	1.9	0.9	2.1	2.4	-1.3	1.1
Bone: connectivity density	1.0	1.6	4.3	-0.7	2.1	1.1	0.3	-0.4	-1.9
Bone: cortical apparent density	2.6	3.4	7.9	-2.3	-0.0	-1.7	-2.8	0.9	-2.0
Bone: cortical area	0.8	1.2	2.3	1.2	-1.0	-0.1	0.7	-1.5	1.3
Bone: cortical porosity	1.9	2.1	4.3	1.8	-0.1	1.2	2.1	-1.3	1.4
Bone: cortical porosity	2.2	2.4	4.0	2.0	-0.8	0.8	1.9	-1.3	1.9
Bone: cortical thickness	4.3	7.1	15.2	-2.4	-2.3	-3.9	-3.7	1.1	-1.1
Bone: cortical thickness	2.2	2.6	5.4	-1.9	-0.5	-2.0	-2.3	0.4	-1.5
Bone: cortical tissue density	2.5	3.3	7.6	-2.2	-0.0	-1.6	-2.8	0.8	-2.0
Bone: elastic displacement	1.0	1.1	2.0	-1.4	-0.0	-1.1	-1.3	0.7	-1.2
Bone: elastic work	0.4	0.5	1.6	-0.3	-1.0	-1.3	-0.7	-0.1	0.1
Bone: endosteal estimation	12.9	27.8	50.0	6.3	1.0	5.5	7.1	-4.7	4.9
Bone: endosteal perimeter	12.0	24.8	44.9	6.1	0.8	5.2	6.7	-4.1	4.8
Bone: final force	0.8	1.3	2.7	1.3	0.1	1.0	1.3	-1.7	0.9
Bone: final moment	0.9	1.4	3.1	1.3	0.2	1.1	1.4	-1.8	0.8
Bone: marrow area	12.6	27.0	48.7	6.2	1.0	5.5	7.0	-4.6	4.8
Bone: maximum diameter	4.0	7.3	13.3	3.1	1.1	3.2	3.7	-2.3	2.0
Bone: maximum force	1.5	2.7	4.3	2.1	-0.3	1.2	1.9	-1.9	1.8
Bone: maximum moment	1.6	2.8	4.3	2.1	-0.2	1.3	1.9	-2.0	1.8
Bone: minimum diameter	9.4	17.3	27.5	5.2	-0.3	3.5	5.2	-4.2	4.4
Bone: periosteal estimation	8.3	17.0	27.6	5.0	0.3	3.9	5.2	-4.2	4.0
Bone: periosteal perimeter	5.1	8.4	14.2	3.8	-0.2	2.6	3.7	-2.1	3.4
Bone: post-yield work	2.2	3.0	5.5	2.3	-0.6	1.3	2.1	-1.1	2.4
Bone: stiffness	1.1	1.7	2.5	1.6	-0.2	1.1	1.5	-1.6	1.4
Bone: tissue strength	1.6	1.6	3.2	-1.6	0.7	-0.4	-1.2	1.2	-1.8
Bone: trabecular number	0.8	1.3	3.5	-0.3	1.9	1.3	0.6	-0.5	-1.3
Bone: trabecular spacing	0.3	0.4	1.1	-0.0	-1.1	-0.9	-0.4	0.2	0.6
Bone: trabecular thickness	0.9	1.0	1.6	1.2	0.3	1.0	1.1	-1.2	0.9
Bone: trabecular tissue density	0.1	0.1	0.4	-0.2	-0.3	-0.4	-0.6	-0.2	-0.0
Breakpoint value in progressive ratio session	2.0	2.2	4.7	-1.3	-1.1	-2.2	-1.4	1.9	-0.5
Distance traveled before self-admin	0.4	0.5	1.0	-0.8	0.9	0.3	-0.1	0.7	-1.0
Distance traveled after self-admin	0.2	0.2	0.4	-0.7	0.1	-0.5	-0.1	0.6	-0.6
Delta time in closed arm before/after self-admin	0.6	0.6	1.7	0.2	1.1	1.3	0.5	0.4	-0.2
Delta time in open arm before/after self-admin	1.4	1.3	3.4	-1.5	0.9	-0.3	-1.1	0.6	-1.8
Diff in mean of infusions in LGA sessions	2.0	2.3	3.9	-0.7	-1.7	-1.9	-1.6	2.0	0.4
Extinction: sum of active levers before priming	0.3	0.3	1.0	-0.5	-0.5	-1.0	-0.6	0.5	-0.0
Active lever presses in extinction session 6	0.3	0.3	0.8	0.1	-0.7	-0.9	0.3	-0.4	0.3
Delta distance traveled before/after self-admin	0.9	0.9	2.5	-1.1	-0.6	-1.6	-1.0	0.2	-0.7
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	-0.2	-0.1	-0.5	0.2	-0.5	-0.4
Time in closed arm before self-admin	0.6	0.6	2.0	-0.5	-0.6	-1.4	-0.4	-1.0	-0.4
Time in closed arm after self-admin	0.1	0.1	0.3	0.3	-0.1	-0.2	0.6	-0.5	0.2
Time in open arm before self-admin	1.6	1.7	4.5	1.0	-1.9	-0.3	0.1	1.0	2.1
Time in open arm after self-admin	0.3	0.3	1.0	0.1	-0.6	0.1	-0.5	1.0	0.5
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	0.1	-0.5	-0.6	0.2	0.4	0.5
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.5	0.7	0.5	1.2	1.2	0.4	0.3
Time to tail flick, vehicle, after self-admin	1.1	1.2	2.6	0.8	1.3	1.6	1.5	-0.4	-0.1
Time to tail flick, test, before self-admin	1.5	1.4	2.9	1.4	0.2	1.6	1.7	-0.1	1.1
Time to tail flick, test, after self-admin	1.9	1.9	3.7	1.4	1.0	1.9	1.8	-1.3	0.6
Delta time to tail flick, vehicle, before/after SA	1.4	1.4	2.7	0.4	1.7	1.4	1.0	-1.5	-0.7
Delta time to tail flick, test, before/after SA	1.2	1.0	2.9	0.5	1.4	1.7	0.7	-0.7	-0.1
Ambulatory time before self-admin	0.5	0.5	1.0	-0.9	0.6	-0.0	-0.5	0.9	-1.0
Ambulatory time after self-admin	0.4	0.4	0.9	-0.9	0.1	-0.8	-0.2	0.4	-1.0
Total heroin consumption	0.1	0.1	0.4	0.3	0.2	0.4	0.6	-0.2	0.2
Area under the delay curve	0.1	0.1	0.4	0.2	0.1	0.2	0.1	0.6	0.3
Delay disc. indifference point, 0s delay	0.2	0.2	1.2	-0.3	0.1	0.1	-0.3	1.1	-0.2
Delay disc. indifference point, 16s delay	0.1	0.1	0.4	0.2	-0.4	-0.3	0.1	-0.0	0.6
Delay disc. indifference point, 2s delay	0.4	0.5	1.0	0.1	1.0	0.9	0.7	-0.2	-0.6
Delay disc. indifference point, 24s delay	0.9	0.9	2.6	1.1	-0.9	-0.1	0.6	-0.4	1.6
Delay disc. indifference point, 4s delay	0.3	0.3	1.1	-0.5	0.7	0.2	-0.1	1.0	-0.4
Delay disc. indifference point, 8s delay	0.5	0.5	1.3	-0.6	-0.1	-0.7	-0.9	1.1	-0.3
Delay discount exponential model param	0.2	0.2	0.5	-0.5	-0.1	-0.5	-0.5	-0.4	-0.7
Delay discount hyperbolic model param	0.1	0.2	0.3	-0.3	-0.3	-0.5	-0.3	-0.5	-0.4
Fecal boli incidents, locomotor time 1	0.4	0.4	1.1	0.7	0.3	1.1	0.3	0.5	0.7
Change in fecal boli incidents, locomotor task	0.4	0.4	0.9	-0.1	0.9	0.4	0.5	-0.9	-0.4
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.6	-0.6	0.4	0.1	-0.6	0.8	-0.6
Bouts of movement, locomotor time 1	0.7	0.8	2.1	0.2	-1.5	-1.1	-0.8	0.5	0.8
Total resting periods, locomotor time 1	0.5	0.6	1.3	0.3	-1.1	-0.7	-0.7	0.8	0.8
Rest time, locomotor task time 1	0.8	0.9	4.3	-0.5	0.2	0.2	-0.7	2.1	0.1
Distance moved, locomotor task time 1	0.5	0.5	1.4	-0.3	-0.9	-1.2	-0.4	-0.9	-0.2
Vertical activity count, locomotor time 1	0.4	0.4	1.4	0.1	-0.8	-0.8	-0.0	-1.2	-0.2
Time >=10cm from walls, locomotor time 2	2.5	2.7	5.4	-1.4	-1.4	-2.3	-1.7	1.9	-0.6
Bouts of movement, locomotor time 2	2.5	2.7	6.4	-0.4	-2.5	-2.5	-1.5	0.9	0.7
Total resting periods, locomotor time 2	2.1	2.2	4.9	-0.3	-2.2	-2.1	-1.4	1.1	0.8
Rest time, locomotor task time 2	2.4	2.8	4.5	-1.7	2.0	0.8	-1.6	2.1	-1.5
Distance moved, locomotor task time 2	1.9	2.2	7.1	-0.8	-2.1	-2.7	-1.0	0.1	-0.1
Vertical activity count, locomotor time 2	1.7	1.9	4.8	0.7	-2.2	-1.6	0.3	-1.5	0.9
Weight adjusted by age	1.6	1.8	4.9	-0.6	-1.3	-1.3	-1.3	2.2	0.2
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.8	0.6	-0.9	0.0	-0.2	0.1	0.9
Locomotion in novel chamber	0.4	0.5	1.3	-0.7	-0.3	-0.6	-0.6	1.1	-0.3
Locomotion in novel chamber post-restriction	0.6	0.7	1.7	0.7	0.3	0.7	1.1	-1.3	0.4
Progressive ratio	0.2	0.2	0.5	0.1	0.5	0.7	0.1	0.5	0.4
Food seeking constrained by brief footshock	1.3	1.5	4.0	1.0	0.1	0.8	1.8	-2.0	0.5
Seeking ratio, punishment vs. effort	0.5	0.6	2.5	0.4	-0.5	-0.3	0.8	-1.6	-0.1
Run reversals in cocaine runway, females	5.2	5.1	11.6	-0.3	-3.3	-3.4	-1.8	1.7	1.3
Run reversals in cocaine runway, males	0.3	0.3	0.6	-0.5	0.7	0.1	-0.3	0.7	-0.6
Latency to leave start box in cocaine runway	2.1	2.3	4.2	-1.8	-0.5	-2.1	-1.6	1.0	-1.5
Latency to leave start box in cocaine runway, F	2.4	2.6	5.8	-1.5	-1.5	-2.4	-1.6	1.5	-0.7
Latency to leave start box in cocaine runway, M	0.7	0.7	1.8	-1.0	0.5	-0.8	-0.7	-0.2	-1.3
Cd content in liver	1.0	1.1	3.6	-0.9	0.9	0.3	-0.4	1.9	-1.1
Co content in liver	0.1	0.1	0.3	0.2	-0.2	0.2	0.1	0.6	-0.1
Cu content in liver	0.3	0.4	0.9	0.2	1.0	0.8	0.4	-0.4	-0.5
Fe content in liver	0.1	0.1	0.3	-0.2	0.3	0.1	0.0	-0.0	-0.5
K content in liver	1.5	1.5	4.5	-0.3	2.1	1.8	0.3	-0.6	-0.9
Mg content in liver	2.3	2.4	7.2	-1.2	2.7	1.5	-0.3	-0.5	-1.8
Mn content in liver	1.6	1.8	6.2	-1.1	2.5	1.3	0.1	-0.1	-1.3
Na content in liver	0.9	1.0	2.3	-0.7	1.5	0.9	-0.3	0.3	-1.4
Rb content in liver	1.2	1.5	4.5	-0.9	2.1	1.3	0.0	0.5	-1.4
Se content in liver	0.9	1.1	2.2	-1.3	1.0	0.1	-1.2	1.5	-0.5
Sr content in liver	0.7	0.7	2.0	0.6	-1.2	-0.6	0.1	-0.1	1.4
Zn content in liver	0.8	0.8	2.4	-0.6	1.6	1.1	-0.1	0.5	-0.9