Hub : Genes

Setd2

Models

#	tissue	modality	RNA phenotype	h²	h² se	h² P	eQTL R²	BLUP R²	ENET R²	LASSO R²	eQTL P	BLUP P	ENET P	LASSO P
1	Adipose	alternative TSS	ENSRNOT00000108520	0.0902	0.0672	1.0e-08	0.051	0.063	0.063	0.063	2.2e-06	1.4e-07	1.6e-07	1.6e-07
2	Adipose	alternative TSS	ENSRNOT00000108520	0.0870	0.0706	2.4e-06	0.038	0.037	0.036	0.040	4.0e-05	5.2e-05	6.1e-05	2.5e-05
3	Adipose	isoform ratio	ENSRNOT00000108520	0.1600	0.0940	0.0e+00	0.203	0.194	0.193	0.193	4.6e-22	4.5e-21	4.8e-21	6.1e-21
4	Adipose	mRNA stability	ENSRNOG00000020915	0.1990	0.1160	0.0e+00	0.223	0.237	0.237	0.237	2.2e-24	5.5e-26	5.9e-26	5.2e-26
5	BLA	gene expression	ENSRNOG00000020915	0.1290	0.1129	6.0e-06	0.124	0.097	0.106	0.118	3.7e-07	7.1e-06	2.6e-06	7.5e-07
6	BLA	mRNA stability	ENSRNOG00000020915	0.0520	0.0540	7.1e-03	0.022	0.028	0.033	0.030	2.3e-02	1.2e-02	6.6e-03	9.7e-03
7	Brain	gene expression	ENSRNOG00000020915	0.0290	0.0290	4.2e-03	0.020	0.025	0.022	0.023	4.8e-03	1.9e-03	3.4e-03	2.9e-03
8	Brain	mRNA stability	ENSRNOG00000020915	0.2484	0.1378	0.0e+00	0.271	0.295	0.276	0.285	3.5e-25	1.4e-27	1.1e-25	1.3e-26
9	Eye	gene expression	ENSRNOG00000020915	0.2600	0.2000	5.9e-03	0.019	0.057	0.002	0.044	1.7e-01	4.9e-02	2.9e-01	7.4e-02
10	Liver	alternative TSS	ENSRNOT00000108520	0.2175	0.1349	5.5e-03	0.003	0.015	0.006	-0.001	1.2e-01	7.6e-03	6.2e-02	4.4e-01
11	Liver	intron excision ratio	chr8:110577589:110580631	0.0489	0.0387	2.3e-06	0.043	0.050	0.046	0.046	1.3e-05	2.7e-06	6.6e-06	6.4e-06
12	Liver	mRNA stability	ENSRNOG00000020915	0.0427	0.0349	2.1e-05	0.042	0.039	0.037	0.040	1.9e-05	3.4e-05	5.7e-05	2.4e-05
13	NAcc	gene expression	ENSRNOG00000020915	0.0690	0.0670	1.3e-04	0.043	0.043	0.046	0.043	3.4e-04	3.9e-04	2.4e-04	3.6e-04
14	NAcc	mRNA stability	ENSRNOG00000020915	0.0407	0.0410	3.1e-03	0.028	0.027	0.022	0.026	3.6e-03	4.0e-03	8.1e-03	4.5e-03
15	PL	gene expression	ENSRNOG00000020915	0.0511	0.0508	8.3e-04	0.037	0.036	0.030	0.037	8.3e-04	8.8e-04	2.2e-03	8.2e-04
16	PL	mRNA stability	ENSRNOG00000020915	0.0722	0.0674	4.3e-05	0.050	0.049	0.045	0.045	1.1e-04	1.4e-04	2.2e-04	2.3e-04

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method.

Trait associations

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16
Length with tail	9.0	33.1	36.9	6.1	6.0	5.1	-6.0	-5.1	-5.1	-6.1	-6.0	-6.1	-4.6	-6.1	-5.7	-6.0	-5.9	-6.0	-5.9
Pavlov. Cond. magazine entry number	7.2	9.0	10.1	3.1	3.0	3.0	-3.2	-3.0	-2.3	-3.1	-3.1	-3.2	-2.5	-3.2	-3.1	-3.0	-3.0	-3.0	-3.0
Pavlov. Cond. response bias	6.8	8.3	9.4	-3.0	-2.9	-2.8	3.1	2.8	2.1	3.0	3.0	3.0	2.7	3.0	3.0	2.9	2.9	2.9	2.9
Tail length	6.5	19.6	22.6	4.7	4.5	4.0	-4.8	-4.0	-3.7	-4.7	-4.6	-4.7	-3.8	-4.7	-4.3	-4.5	-4.5	-4.6	-4.5
Pavlov. Cond. magazine entry latency	6.4	8.3	9.3	-3.0	-2.8	-3.0	3.0	3.0	2.2	3.0	2.9	3.0	2.6	3.0	3.0	2.9	2.9	2.9	2.9
Length without tail	6.3	13.8	15.1	3.8	3.9	3.5	-3.7	-3.5	-3.7	-3.8	-3.9	-3.8	-2.8	-3.8	-3.8	-3.9	-3.7	-3.8	-3.8
Pavlov. Cond. index score	6.2	8.0	9.0	-2.9	-2.8	-2.7	3.0	2.7	2.1	2.9	2.9	3.0	2.7	3.0	2.9	2.8	2.8	2.8	2.8
Pavlov. Cond. latency score	6.2	7.9	8.9	-2.9	-2.7	-2.7	3.0	2.7	2.2	2.9	2.8	3.0	2.8	3.0	3.0	2.8	2.8	2.8	2.8
Body weight	6.1	25.7	34.0	5.5	5.8	4.6	-5.1	-4.6	-5.1	-5.4	-5.5	-5.3	-2.5	-5.3	-4.8	-5.1	-5.1	-5.2	-5.1
Tibia length	6.0	17.0	22.4	4.5	4.7	3.8	-4.2	-3.8	-3.8	-4.5	-4.6	-4.4	-1.5	-4.4	-4.1	-4.2	-4.1	-4.2	-4.1
Locomotor activity	5.7	9.1	11.9	3.1	3.1	2.5	-3.1	-2.5	-2.5	-3.1	-3.2	-3.1	-2.2	-3.1	-2.9	-3.3	-3.4	-3.4	-3.3
Locomotor testing distance	5.5	9.0	12.1	3.1	3.2	2.6	-3.0	-2.6	-2.3	-3.1	-3.2	-3.1	-2.1	-3.1	-2.8	-3.3	-3.5	-3.5	-3.3
Pavlov. Cond. lever-magazine prob. diff.	5.5	6.9	7.9	-2.7	-2.6	-2.5	2.8	2.5	1.8	2.7	2.7	2.8	2.5	2.8	2.7	2.6	2.6	2.6	2.6
Seeking ratio, punishment vs. effort	5.5	6.7	9.1	-2.6	-2.4	-3.0	2.4	3.0	2.6	2.6	2.6	2.6	2.2	2.6	2.6	2.5	2.6	2.5	2.6
Pavlov. Cond. lever latency	5.2	6.6	8.4	2.6	2.5	2.4	-2.7	-2.4	-2.0	-2.6	-2.6	-2.7	-2.9	-2.7	-2.7	-2.6	-2.6	-2.6	-2.6
Zn content in liver	4.7	5.1	6.7	2.3	2.5	2.6	-2.2	-2.6	-2.3	-2.3	-2.3	-2.2	-1.1	-2.2	-2.2	-2.3	-2.3	-2.3	-2.3
Cu content in liver	4.4	5.3	7.1	2.2	2.4	2.7	-2.2	-2.7	-2.2	-2.2	-2.3	-2.2	-1.9	-2.2	-2.2	-2.3	-2.3	-2.3	-2.3
Soleus weight	3.7	10.7	12.5	3.5	3.5	3.2	-3.2	-3.2	-3.3	-3.5	-3.5	-3.4	-1.6	-3.4	-3.2	-3.4	-3.4	-3.3	-3.4
Std. dev. time between licks in bursts	3.7	4.4	6.1	-2.2	-1.9	-2.2	2.3	2.2	1.5	2.2	2.1	2.2	1.8	2.2	2.5	1.9	1.9	1.9	1.9
Progressive ratio	3.5	4.1	5.3	2.0	1.9	2.3	-1.9	-2.3	-2.1	-2.0	-2.0	-2.0	-1.5	-2.0	-2.1	-2.0	-2.1	-2.0	-2.0
Short access day 1 total inactive lever presses	3.3	3.6	5.4	-2.0	-1.8	-1.7	2.2	1.7	1.4	2.0	2.0	2.1	1.7	2.1	2.3	1.8	1.8	1.8	1.8
Pavlov. Cond. lever contacts	3.0	3.6	5.3	-1.9	-1.8	-1.7	2.0	1.7	1.4	1.9	1.9	2.0	2.3	2.0	1.9	1.9	1.9	1.9	1.9
Bone: tissue strength	3.0	2.9	3.5	1.8	1.8	1.4	-1.8	-1.4	-1.9	-1.8	-1.8	-1.7	-1.4	-1.7	-1.6	-1.8	-1.8	-1.8	-1.8
Delay discounting total patch changes 24 sec	2.9	3.7	4.6	2.0	2.2	2.1	-1.9	-2.1	-1.9	-2.0	-2.0	-2.0	-1.4	-2.0	-2.0	-1.7	-1.9	-1.9	-1.8
Conditioned locomotion	2.9	3.5	4.3	-1.9	-2.1	-1.9	1.9	1.9	2.0	1.9	2.0	1.9	0.9	1.9	1.8	1.9	1.9	1.9	1.9
Cd content in liver	2.9	3.1	5.6	1.6	1.5	1.8	-1.7	-1.8	-1.9	-1.6	-1.6	-1.6	-2.4	-1.6	-1.8	-1.8	-1.8	-1.8	-1.8
Delay discounting total patch changes 18 sec	2.7	3.6	4.7	1.8	1.9	2.2	-1.8	-2.2	-1.5	-1.8	-1.8	-1.8	-2.1	-1.8	-1.7	-1.9	-1.9	-2.1	-1.8
Delay discount exponential model param	2.7	2.8	3.8	1.7	1.7	1.4	-1.5	-1.4	-1.8	-1.7	-1.7	-1.7	-1.3	-1.7	-1.7	-1.9	-1.8	-1.9	-1.9
Delay discount hyperbolic model param	2.6	2.8	3.8	1.7	1.7	1.4	-1.5	-1.4	-1.8	-1.7	-1.7	-1.7	-1.3	-1.7	-1.7	-1.9	-1.8	-1.9	-1.9
Heart weight	2.5	3.5	6.3	1.9	2.0	1.6	-1.8	-1.6	-2.5	-1.9	-2.0	-1.9	-1.1	-1.9	-2.0	-1.8	-1.9	-1.9	-1.8
Pavlov. Cond. change in total contacts	2.4	3.3	4.9	1.9	2.2	1.8	-1.7	-1.8	-1.9	-1.9	-2.0	-1.8	-0.6	-1.8	-1.6	-1.9	-1.9	-1.9	-1.9
Fe content in liver	2.4	2.8	6.9	1.3	1.2	1.9	-1.5	-1.9	-1.9	-1.4	-1.4	-1.4	-2.6	-1.4	-1.7	-1.6	-1.6	-1.6	-1.6
Condit. Reinf. lever presses	2.3	3.2	4.3	1.9	2.1	1.8	-1.7	-1.8	-1.9	-1.9	-1.9	-1.8	-0.6	-1.8	-1.7	-1.8	-1.8	-1.8	-1.8
Area under the delay curve	2.3	2.4	3.2	-1.6	-1.5	-1.3	1.4	1.3	1.7	1.6	1.6	1.5	1.2	1.5	1.5	1.8	1.6	1.8	1.8
Delay disc. indifference point, 4s delay	2.3	2.4	3.2	-1.6	-1.6	-1.3	1.5	1.3	1.5	1.6	1.6	1.5	1.2	1.5	1.6	1.8	1.6	1.8	1.7
Delay disc. indifference point, 8s delay	2.3	2.3	3.1	-1.5	-1.5	-1.3	1.4	1.3	1.7	1.5	1.6	1.5	1.1	1.5	1.5	1.7	1.6	1.8	1.7
Seeking ratio, delayed vs. immediate footshock	2.3	2.7	4.2	-1.8	-1.8	-0.7	2.0	0.7	0.8	1.8	1.8	1.8	1.2	1.8	1.9	1.7	1.9	1.8	1.8
Time to tail flick, vehicle, before self-admin	2.2	2.3	4.3	1.4	1.3	1.9	-1.4	-1.9	-2.1	-1.4	-1.4	-1.4	-1.3	-1.4	-1.5	-1.3	-1.3	-1.4	-1.3
Condit. Reinf. active minus inactive responses	2.1	2.6	3.6	1.7	1.9	1.7	-1.5	-1.7	-1.7	-1.7	-1.7	-1.6	-0.7	-1.6	-1.5	-1.6	-1.6	-1.6	-1.6
Progressive ratio test 2 inactive lever presses	2.1	2.4	3.5	-1.6	-1.4	-1.9	1.7	1.9	1.2	1.6	1.5	1.6	1.4	1.6	1.6	1.4	1.5	1.5	1.4
Reaction time premature initiation rate	2.0	2.7	3.1	1.7	1.7	1.6	-1.7	-1.6	-1.5	-1.7	-1.7	-1.7	-1.4	-1.7	-1.6	-1.7	-1.6	-1.6	-1.7
Condit. Reinf. lever reinforcers received	2.0	2.8	3.5	1.7	1.9	1.6	-1.6	-1.6	-1.7	-1.7	-1.8	-1.7	-1.0	-1.7	-1.7	-1.7	-1.7	-1.7	-1.7
Cocaine response after cond. not corrected	1.8	2.0	3.7	1.4	1.5	1.4	-1.3	-1.4	-1.9	-1.4	-1.4	-1.4	-1.0	-1.4	-1.4	-1.4	-1.4	-1.4	-1.4
Condit. Reinf. active responses	1.8	2.5	3.0	1.6	1.7	1.6	-1.5	-1.6	-1.6	-1.6	-1.7	-1.6	-1.0	-1.6	-1.6	-1.6	-1.6	-1.6	-1.6
Total zone transitions, NPP test	1.8	2.6	4.5	1.9	2.1	1.4	-1.5	-1.4	-0.9	-1.8	-1.9	-1.7	0.7	-1.7	-1.5	-1.6	-1.6	-1.6	-1.6
Run reversals in cocaine runway, females	1.8	1.8	2.6	-1.3	-1.3	-1.6	1.1	1.6	1.3	1.3	1.4	1.3	0.9	1.3	1.2	1.4	1.3	1.5	1.4
Incentive Sensitization - Responses	1.7	1.7	1.8	-1.3	-1.3	-1.2	1.3	1.2	1.2	1.3	1.3	1.3	1.1	1.3	1.3	1.3	1.4	1.3	1.3
Condit. Reinf. active-inactive response ratio	1.6	1.7	2.6	1.4	1.6	1.4	-1.3	-1.4	-1.6	-1.4	-1.4	-1.3	-0.4	-1.3	-1.2	-1.2	-1.2	-1.2	-1.2
Incentive Sensitization - Breakpoint	1.6	1.6	1.8	-1.3	-1.3	-1.3	1.3	1.3	1.2	1.3	1.3	1.3	1.0	1.3	1.3	1.3	1.3	1.2	1.3
Distance moved, locomotor task time 1	1.6	1.7	2.2	1.4	1.5	0.9	-1.4	-0.9	-1.2	-1.4	-1.4	-1.4	-0.8	-1.4	-1.5	-1.3	-1.5	-1.4	-1.3
Time >=10cm from walls, locomotor time 2	1.6	1.6	1.9	1.3	1.3	1.3	-1.3	-1.3	-1.1	-1.3	-1.3	-1.3	-1.0	-1.3	-1.3	-1.4	-1.3	-1.3	-1.4
Rb content in liver	1.6	2.0	9.2	1.0	0.7	1.2	-1.3	-1.2	-1.3	-1.1	-1.0	-1.2	-3.0	-1.2	-1.3	-1.5	-1.5	-1.4	-1.5
Condit. Reinf. lever presses	1.5	2.1	2.6	-1.4	-1.3	-1.5	1.5	1.5	1.3	1.4	1.4	1.5	1.6	1.5	1.5	1.4	1.4	1.4	1.4
Pavlov. Cond. change in total contacts	1.5	1.6	2.0	-1.4	-1.4	-1.1	1.4	1.1	0.8	1.4	1.4	1.4	0.8	1.4	1.3	1.2	1.2	1.2	1.2
Time in closed arm before self-admin	1.5	1.7	2.1	1.4	1.2	1.0	-1.3	-1.0	-1.2	-1.4	-1.4	-1.4	-1.1	-1.4	-1.3	-1.4	-1.4	-1.4	-1.5
BMI without tail	1.4	3.0	5.3	2.0	2.3	1.4	-1.8	-1.4	-1.6	-2.0	-2.0	-1.9	-0.0	-1.9	-1.5	-1.7	-1.7	-1.8	-1.7
Saline control response	1.4	1.8	2.2	1.4	1.2	1.3	-1.4	-1.3	-0.7	-1.4	-1.4	-1.4	-1.5	-1.4	-1.5	-1.4	-1.4	-1.4	-1.4
Degree of sensitization distance	1.4	1.4	2.7	1.1	0.9	1.2	-1.2	-1.2	-1.1	-1.1	-1.1	-1.2	-1.6	-1.2	-1.2	-1.2	-1.2	-1.2	-1.2
Bone: trabecular spacing	1.4	1.8	3.8	1.3	1.3	1.3	-1.4	-1.3	-1.9	-1.3	-1.3	-1.4	-1.3	-1.4	-1.3	-1.2	-1.2	-1.2	-1.2
Intraocular pressure	1.3	1.9	4.3	1.2	0.8	1.5	-1.3	-1.5	-1.3	-1.2	-1.2	-1.3	-2.1	-1.3	-1.2	-1.4	-1.4	-1.4	-1.4
Food consumed during 24 hour testing period	1.3	1.6	2.1	1.4	1.4	1.2	-1.2	-1.2	-1.2	-1.4	-1.4	-1.3	-0.6	-1.3	-1.3	-1.3	-1.3	-1.3	-1.3
Locomotion distance, session 3	1.3	1.4	3.4	-1.0	-0.7	-1.3	1.1	1.3	1.5	1.0	1.0	1.1	1.8	1.1	1.2	1.1	1.0	1.1	1.0
Latency to leave start box in cocaine runway, F	1.3	1.5	2.8	1.3	1.3	1.0	-1.2	-1.0	-1.7	-1.3	-1.3	-1.2	-0.7	-1.2	-1.3	-1.3	-1.1	-1.3	-1.3
Bone: endosteal perimeter	1.2	2.5	3.5	-1.6	-1.4	-1.9	1.6	1.9	1.7	1.6	1.5	1.6	1.3	1.6	1.6	1.5	1.5	1.5	1.5
Bone: periosteal perimeter	1.2	2.0	3.2	-1.4	-1.3	-1.8	1.4	1.8	1.3	1.4	1.4	1.4	1.1	1.4	1.5	1.3	1.4	1.3	1.4
Total heroin consumption	1.2	1.4	2.1	1.2	1.5	0.8	-1.3	-0.8	-1.2	-1.2	-1.2	-1.2	-1.0	-1.2	-1.0	-1.3	-1.2	-1.5	-1.3
Delay disc. indifference point, 16s delay	1.2	1.2	2.3	-1.0	-1.0	-1.3	0.9	1.3	1.5	1.1	1.1	1.0	0.9	1.0	1.0	1.1	1.0	1.1	1.1
Liver weight, right	1.1	1.8	2.3	1.5	1.5	1.5	-1.5	-1.5	-1.0	-1.4	-1.4	-1.5	-0.8	-1.5	-1.4	-1.2	-1.2	-1.2	-1.2
Delay discounting total patch changes 0 sec	1.1	1.9	2.3	1.4	1.5	1.1	-1.4	-1.1	-0.7	-1.4	-1.4	-1.4	-1.3	-1.4	-1.5	-1.5	-1.5	-1.5	-1.4
Intermittent access total locomotion	1.1	1.3	2.2	-1.2	-1.0	-1.1	1.2	1.1	1.5	1.1	1.1	1.2	1.0	1.2	1.1	1.0	1.1	1.0	1.0
Time in familiar zone, hab. session 1	1.1	1.1	1.5	-1.2	-1.2	-1.2	1.1	1.2	0.7	1.2	1.2	1.1	-0.1	1.1	1.1	0.9	0.9	0.9	0.9
Time in novel zone, NPP test	1.1	1.1	1.3	1.1	1.1	1.1	-1.1	-1.1	-0.0	-1.1	-1.1	-1.1	-0.9	-1.1	-1.1	-1.1	-1.1	-1.1	-1.1
Delay disc. indifference point, 24s delay	1.1	1.1	2.1	-0.9	-0.9	-1.2	0.8	1.2	1.4	0.9	1.0	0.9	0.7	0.9	0.9	1.1	1.0	1.1	1.1
Parametrial fat weight	1.0	1.9	2.4	1.5	1.5	1.4	-1.5	-1.4	-1.1	-1.5	-1.5	-1.5	-0.8	-1.5	-1.5	-1.3	-1.3	-1.4	-1.2
Mean time between licks in bursts	1.0	1.4	1.8	-1.3	-1.1	-1.1	1.3	1.1	1.1	1.3	1.2	1.3	1.2	1.3	1.3	1.1	1.1	1.1	1.1
Cocaine response before conditioning	1.0	1.2	1.7	1.2	1.3	0.9	-1.2	-0.9	-0.5	-1.2	-1.3	-1.2	-0.0	-1.2	-1.2	-1.1	-1.1	-1.1	-1.1
Time in open arm before self-admin	1.0	1.1	1.5	-1.1	-0.8	-0.8	1.0	0.8	0.9	1.1	1.1	1.1	0.8	1.1	1.0	1.2	1.2	1.1	1.2
Indifference point 0 sec	0.9	1.5	1.8	1.3	1.3	0.9	-1.3	-0.9	-0.4	-1.3	-1.3	-1.3	-1.2	-1.3	-1.4	-1.3	-1.3	-1.4	-1.3
Reaction time premature initiations	0.9	1.3	1.7	1.2	1.2	0.8	-1.2	-0.8	-0.8	-1.2	-1.2	-1.2	-1.0	-1.2	-1.1	-1.3	-1.2	-1.3	-1.2
Pavlov. Cond. lever contacts	0.9	1.3	2.2	1.2	1.5	1.2	-1.1	-1.2	-1.0	-1.2	-1.3	-1.1	-0.0	-1.1	-0.9	-1.1	-1.1	-1.1	-1.1
Conditioned reinforcement - inactives	0.9	1.0	1.4	-1.0	-1.0	-1.2	1.0	1.2	0.5	1.0	1.0	1.0	0.8	1.0	1.1	1.0	1.0	1.0	1.0
Progressive ratio test 2 active lever presses	0.9	1.0	1.4	-1.0	-0.9	-1.1	1.1	1.1	1.2	1.0	1.0	1.0	0.9	1.0	1.1	0.9	1.0	0.8	0.9
Number of responses in last shaping day	0.9	0.9	1.5	-0.9	-0.8	-1.2	1.0	1.2	0.7	0.9	0.9	0.9	0.7	0.9	1.1	0.9	1.0	0.8	0.9
Total locomotion distance, NPP test	0.9	1.2	1.7	1.2	1.3	1.2	-1.1	-1.2	-1.1	-1.2	-1.2	-1.1	0.2	-1.1	-1.1	-1.0	-1.0	-1.0	-1.0
Locomotion velocity, NPP test	0.9	1.3	1.9	1.3	1.4	1.2	-1.1	-1.2	-1.0	-1.2	-1.3	-1.2	0.2	-1.2	-1.2	-1.0	-1.1	-1.0	-1.1
Bone: final moment	0.9	1.6	2.9	1.4	1.4	0.9	-1.2	-0.9	-1.7	-1.3	-1.4	-1.3	-0.7	-1.3	-1.1	-1.3	-1.2	-1.3	-1.2
Locomotion in novel chamber post-restriction	0.9	1.1	2.0	1.0	1.0	1.4	-1.0	-1.4	-1.4	-1.0	-1.0	-1.0	-0.7	-1.0	-1.0	-0.9	-1.0	-0.9	-1.0
Delay discounting total patch changes 12 sec	0.8	1.1	1.6	1.1	1.1	1.1	-1.2	-1.1	-0.7	-1.1	-1.0	-1.1	-1.1	-1.1	-1.3	-0.8	-1.0	-0.9	-0.8
Intermitt. access day 15 inactive lever presses	0.8	0.9	1.4	-0.9	-0.8	-1.2	0.8	1.2	0.6	0.9	0.9	0.9	0.7	0.9	0.9	1.0	1.0	0.9	1.0
Novel to familiar place preference ratio	0.8	0.8	1.0	0.9	1.0	1.0	-0.9	-1.0	0.2	-1.0	-1.0	-0.9	-0.6	-0.9	-0.9	-1.0	-1.0	-1.0	-1.0
Novelty place preference	0.8	0.8	1.0	0.9	1.0	1.0	-1.0	-1.0	0.2	-0.9	-1.0	-0.9	-0.7	-0.9	-0.9	-1.0	-1.0	-0.9	-1.0
Vertical activity count, locomotor time 1	0.8	0.9	1.2	1.0	0.9	0.8	-0.9	-0.8	-1.0	-1.0	-1.0	-0.9	-0.6	-0.9	-1.1	-0.9	-1.0	-1.1	-0.9
Distance moved, locomotor task time 2	0.8	0.9	1.9	1.1	1.1	0.4	-1.1	-0.4	-0.6	-1.1	-1.1	-1.1	-0.6	-1.1	-1.4	-1.0	-0.7	-1.0	-1.0
Food seeking constrained by brief footshock	0.8	1.0	1.9	-0.9	-0.9	-1.4	0.9	1.4	1.3	0.9	0.9	1.0	1.0	1.0	0.7	0.9	0.8	0.9	0.9
Delay discounting water rate 24 sec	0.7	1.0	1.4	1.0	0.9	1.2	-1.0	-1.2	-1.1	-1.0	-1.0	-1.0	-0.8	-1.0	-0.9	-1.0	-0.8	-1.1	-1.0
Social time	0.7	0.9	1.9	-0.8	-0.7	-1.4	0.6	1.4	0.9	0.8	0.8	0.7	0.7	0.7	0.7	1.1	0.9	1.0	1.1
Intermittent access intake day 1-15 change	0.7	0.7	2.1	-0.7	-0.8	-1.4	0.9	1.4	0.4	0.7	0.7	0.8	0.5	0.8	0.7	0.6	0.7	0.6	0.6
Progressive ratio test 2 breakpoint	0.7	0.8	1.1	-0.9	-0.8	-1.0	1.0	1.0	1.0	0.9	0.9	1.0	0.8	1.0	0.9	0.8	0.9	0.8	0.8
Short access day 1 total infusions	0.7	0.8	1.3	-1.0	-0.9	-0.4	1.1	0.4	0.4	1.0	1.0	1.0	0.7	1.0	1.1	0.9	0.9	0.9	0.9
Locomotion distance, session 1	0.7	0.9	1.5	1.1	1.2	0.9	-0.8	-0.9	-0.7	-1.1	-1.1	-1.0	0.5	-1.0	-0.8	-1.0	-0.9	-1.0	-0.9
Locomotion distance, session 7	0.7	0.9	2.7	-0.9	-0.8	-1.2	0.9	1.2	1.6	0.9	0.9	0.9	0.8	0.9	1.1	0.8	0.7	0.8	0.7
Condit. Reinf. inactive responses	0.7	0.9	1.1	-0.9	-1.0	-1.0	0.9	1.0	0.8	0.9	0.9	0.9	0.9	0.9	0.9	1.0	1.1	1.0	1.1
Bone: final force	0.7	1.2	2.1	1.2	1.2	0.8	-1.1	-0.8	-1.5	-1.2	-1.2	-1.2	-0.7	-1.2	-1.0	-1.1	-1.0	-1.1	-1.0
Bone: maximum moment	0.7	1.2	1.5	1.2	1.2	0.7	-1.1	-0.7	-1.2	-1.2	-1.2	-1.2	-0.9	-1.2	-1.0	-1.2	-1.1	-1.2	-1.1
Bone: trabecular number	0.7	1.1	3.0	-0.9	-0.9	-1.1	1.0	1.1	1.7	0.9	0.9	0.9	1.1	0.9	1.0	0.9	0.9	0.9	0.9
K content in liver	0.7	0.7	1.1	0.9	1.1	1.1	-0.8	-1.1	-0.9	-0.9	-0.9	-0.9	0.2	-0.9	-0.8	-0.7	-0.7	-0.7	-0.7
Left kidney weight	0.6	1.6	2.5	1.5	1.6	1.1	-1.2	-1.1	-1.1	-1.5	-1.5	-1.4	0.5	-1.4	-1.3	-1.2	-1.1	-1.2	-1.2
Intermittent access intake escalation	0.6	0.6	2.1	-0.7	-0.6	-1.5	0.8	1.5	0.5	0.6	0.6	0.7	0.4	0.7	0.8	0.5	0.5	0.5	0.5
Intermittent access day 15 total locomotion	0.6	0.7	2.0	-0.8	-0.7	-1.0	0.9	1.0	1.4	0.8	0.7	0.8	0.6	0.8	0.9	0.6	0.6	0.6	0.6
Cocaine induced anxiety	0.6	0.6	0.8	-0.8	-0.9	-0.9	0.7	0.9	0.5	0.8	0.8	0.8	0.6	0.8	0.7	0.9	0.9	0.9	0.9
Bone: maximum force	0.6	1.0	1.3	1.1	1.1	0.7	-1.0	-0.7	-1.1	-1.1	-1.1	-1.1	-0.9	-1.1	-0.9	-1.1	-1.0	-1.1	-1.0
Run reversals in cocaine runway, males	0.6	0.6	1.2	0.8	0.8	0.6	-0.8	-0.6	-1.1	-0.8	-0.7	-0.8	-0.5	-0.8	-0.9	-0.8	-0.7	-0.8	-0.7
Retroperitoneal fat weight	0.5	1.7	2.3	1.5	1.5	1.0	-1.4	-1.0	-1.0	-1.4	-1.4	-1.5	-0.8	-1.5	-1.4	-1.3	-1.2	-1.3	-1.2
Times rat made contact with spout	0.5	0.5	0.9	0.7	0.6	0.7	-0.8	-0.7	-0.9	-0.7	-0.7	-0.7	-0.7	-0.7	-0.9	-0.6	-0.6	-0.6	-0.6
Mean num. licks in bursts	0.5	0.6	1.4	0.9	0.8	0.6	-0.9	-0.6	-0.3	-0.9	-0.9	-0.9	-0.4	-0.9	-1.2	-0.7	-0.7	-0.7	-0.7
Light reinforcement 1	0.5	1.0	1.3	1.1	1.1	1.0	-1.0	-1.0	-0.9	-1.1	-1.1	-1.1	-0.6	-1.1	-0.9	-0.9	-1.0	-1.0	-0.9
Intermittent access total infusions	0.5	0.6	1.3	-0.7	-0.5	-1.1	0.8	1.1	1.0	0.7	0.6	0.7	0.7	0.7	0.8	0.4	0.6	0.5	0.4
Time in novel zone, hab. session 1	0.5	0.5	0.8	0.8	0.7	0.6	-0.8	-0.6	-0.6	-0.8	-0.8	-0.8	-0.2	-0.8	-0.9	-0.5	-0.5	-0.5	-0.5
Bone: elastic work	0.5	0.6	1.1	0.8	1.0	0.5	-0.8	-0.5	-1.0	-0.8	-0.9	-0.8	0.1	-0.8	-0.7	-0.8	-0.8	-0.8	-0.8
Sum of active levers in priming session hrs 5-6	0.5	0.4	0.6	0.7	0.7	0.7	-0.8	-0.7	-0.3	-0.7	-0.7	-0.7	-0.7	-0.7	-0.8	-0.7	-0.5	-0.6	-0.6
Time to tail flick, vehicle, after self-admin	0.5	0.5	0.8	0.8	0.8	0.8	-0.9	-0.8	-0.5	-0.8	-0.8	-0.8	-0.3	-0.8	-0.9	-0.7	-0.6	-0.7	-0.6
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.8	-0.7	-0.6	-0.8	0.6	0.8	0.9	0.7	0.7	0.7	0.9	0.7	0.7	0.7	0.6	0.7	0.7
Fecal boli incidents, locomotor time 1	0.5	0.5	1.4	0.7	0.8	0.9	-0.6	-0.9	-1.2	-0.7	-0.7	-0.6	-0.4	-0.6	-0.6	-0.5	-0.6	-0.5	-0.6
Rest time, locomotor task time 1	0.5	0.5	0.9	-0.8	-0.9	0.3	0.9	-0.3	0.2	0.8	0.8	0.8	0.4	0.8	0.8	0.8	1.0	0.9	0.7
Latency to leave start box in cocaine runway	0.5	0.5	1.6	0.6	0.6	1.1	-0.6	-1.1	-1.3	-0.6	-0.6	-0.6	-0.3	-0.6	-0.7	-0.6	-0.5	-0.6	-0.6
Mn content in liver	0.5	0.6	1.1	0.9	1.0	0.4	-0.7	-0.4	0.1	-0.9	-0.9	-0.8	0.4	-0.8	-0.6	-0.8	-0.8	-0.7	-0.8
Na content in liver	0.5	0.5	1.8	0.6	0.4	0.7	-0.7	-0.7	-0.3	-0.6	-0.6	-0.6	-1.4	-0.6	-0.7	-0.6	-0.7	-0.7	-0.7
BMI with tail	0.4	1.3	3.0	1.2	1.7	1.0	-0.8	-1.0	-1.5	-1.2	-1.3	-1.0	1.4	-1.0	-0.8	-0.8	-0.9	-0.9	-0.9
Reaction time num false alarms	0.4	0.5	1.4	-0.6	-0.7	-1.2	0.7	1.2	1.0	0.6	0.6	0.6	-0.0	0.6	0.7	0.3	0.4	0.4	0.4
Reaction time trials AUC	0.4	0.6	1.3	-0.8	-0.9	-1.1	0.7	1.1	0.9	0.8	0.8	0.8	0.2	0.8	0.8	0.5	0.7	0.4	0.6
Social response proportion	0.4	0.5	1.2	0.7	0.6	0.4	-0.9	-0.4	-0.3	-0.7	-0.6	-0.8	-1.1	-0.8	-1.1	-0.5	-0.6	-0.5	-0.6
Pavlov. Cond. lever latency	0.4	0.5	1.1	-0.8	-1.1	-0.7	0.6	0.7	0.7	0.8	0.8	0.7	-0.2	0.7	0.5	0.8	0.8	0.8	0.8
Pavlov. Cond. magazine entry number	0.4	0.5	1.9	0.6	0.3	0.7	-0.7	-0.7	-0.3	-0.6	-0.5	-0.7	-1.4	-0.7	-0.8	-0.6	-0.6	-0.6	-0.6
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.8	-0.7	-0.9	-0.8	0.6	0.8	0.9	0.7	0.7	0.7	-0.6	0.7	0.6	0.5	0.5	0.5	0.5
Intermittent access day 15 total infusions	0.4	0.5	1.6	-0.6	-0.5	-1.3	0.7	1.3	0.7	0.6	0.5	0.6	0.5	0.6	0.7	0.4	0.5	0.4	0.4
Lifetime Intake	0.4	0.4	0.8	-0.6	-0.4	-0.8	0.7	0.8	0.9	0.6	0.6	0.6	0.6	0.6	0.7	0.4	0.5	0.4	0.4
Short access total infusions	0.4	0.5	0.8	-0.7	-0.6	-0.6	0.9	0.6	0.9	0.7	0.7	0.8	0.7	0.8	0.9	0.6	0.6	0.6	0.6
Condit. Reinf. active-inactive response ratio	0.4	0.4	1.3	0.5	0.4	0.5	-0.6	-0.5	-0.8	-0.5	-0.5	-0.5	-1.2	-0.5	-0.7	-0.6	-0.6	-0.6	-0.6
Total zone transitions, hab. session 1	0.4	0.6	1.3	1.0	1.1	0.5	-0.7	-0.5	-0.1	-0.9	-1.0	-0.9	0.6	-0.9	-0.7	-0.7	-0.7	-0.7	-0.7
Time in familiar zone, hab. session 2	0.4	0.4	0.7	-0.7	-0.6	-0.7	0.8	0.7	0.2	0.7	0.7	0.7	0.4	0.7	0.8	0.5	0.5	0.5	0.5
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.6	0.7	0.7	0.5	-0.7	-0.5	-0.3	-0.7	-0.7	-0.7	-0.8	-0.7	-0.5	-0.8	-0.8	-0.8	-0.8
Bone: maximum diameter	0.4	0.8	1.3	-0.9	-0.8	-1.1	0.9	1.1	0.4	0.9	0.9	0.9	0.8	0.9	0.9	0.8	0.9	0.8	0.9
Bone: minimum diameter	0.4	0.8	1.5	-0.8	-0.7	-1.2	0.9	1.2	0.9	0.8	0.8	0.8	0.8	0.8	1.0	0.7	0.8	0.7	0.8
Time in open arm after self-admin	0.4	0.5	2.7	-0.4	-0.3	-1.2	0.3	1.2	1.7	0.4	0.4	0.4	0.3	0.4	0.5	0.4	0.4	0.4	0.4
Delay disc. indifference point, 2s delay	0.4	0.5	0.8	-0.6	-0.6	-0.6	0.5	0.6	0.9	0.6	0.6	0.6	0.5	0.6	0.6	0.9	0.7	0.9	0.9
Epididymis fat weight	0.3	0.8	2.7	0.8	0.8	1.3	-0.8	-1.3	-1.6	-0.8	-0.8	-0.8	-0.6	-0.8	-0.7	-0.7	-0.6	-0.7	-0.7
Glucose	0.3	0.5	1.0	0.7	0.8	1.0	-0.7	-1.0	-0.4	-0.7	-0.7	-0.6	-0.1	-0.6	-0.7	-0.5	-0.6	-0.6	-0.6
Indifference point function ln k	0.3	0.4	1.9	-0.4	-0.3	-1.1	0.6	1.1	0.9	0.4	0.3	0.5	1.4	0.5	0.5	0.2	0.3	0.4	0.1
Indifference point function log k	0.3	0.4	1.9	-0.4	-0.3	-1.1	0.6	1.1	0.9	0.4	0.3	0.5	1.4	0.5	0.5	0.2	0.3	0.4	0.1
Delay discounting water rate 12 sec	0.3	0.5	0.8	0.7	0.8	0.7	-0.6	-0.7	-0.9	-0.7	-0.7	-0.7	-0.0	-0.6	-0.4	-0.8	-0.7	-0.7	-0.8
Delay discounting water rate 6 sec	0.3	0.4	0.6	0.7	0.7	0.5	-0.6	-0.5	-0.4	-0.7	-0.7	-0.7	0.2	-0.7	-0.7	-0.6	-0.6	-0.8	-0.6
Locomotor testing rearing	0.3	0.5	1.1	0.6	0.7	0.5	-0.6	-0.5	-0.4	-0.6	-0.6	-0.6	-0.9	-0.6	-0.3	-0.9	-1.0	-1.0	-0.9
Reaction time number correct	0.3	0.5	1.1	-0.7	-0.7	-1.0	0.6	1.0	0.9	0.7	0.7	0.7	0.2	0.7	0.7	0.4	0.6	0.3	0.5
Reaction time mean minus median AUC	0.3	0.3	1.0	0.5	0.5	1.0	-0.4	-1.0	-0.7	-0.5	-0.5	-0.5	-0.1	-0.5	-0.5	-0.5	-0.5	-0.5	-0.5
Reaction time trials correct on left	0.3	0.5	1.1	-0.7	-0.7	-1.0	0.6	1.0	0.9	0.7	0.7	0.7	0.2	0.7	0.7	0.4	0.6	0.3	0.5
Reaction time trials on left	0.3	0.5	1.1	-0.7	-0.8	-1.1	0.6	1.1	0.9	0.7	0.7	0.7	0.2	0.7	0.7	0.5	0.6	0.4	0.5
Reaction time trials completed	0.3	0.5	1.1	-0.7	-0.8	-1.1	0.6	1.1	0.9	0.7	0.7	0.7	0.2	0.7	0.7	0.5	0.6	0.4	0.5
Social responses	0.3	0.4	0.7	0.7	0.7	0.4	-0.8	-0.4	-0.2	-0.7	-0.7	-0.7	-0.4	-0.7	-0.7	-0.5	-0.6	-0.6	-0.6
Cocaine response after cond. corrected	0.3	0.3	1.6	0.5	0.5	0.6	-0.4	-0.6	-1.3	-0.5	-0.5	-0.5	-0.6	-0.5	-0.5	-0.5	-0.5	-0.5	-0.5
Conditioned locomotion	0.3	0.3	0.7	-0.7	-0.5	-0.1	0.8	0.1	0.7	0.6	0.6	0.7	0.7	0.7	0.5	0.5	0.7	0.5	0.5
Post-drug Anxiety	0.3	0.3	0.4	-0.5	-0.7	-0.5	0.4	0.5	0.1	0.5	0.6	0.5	0.3	0.5	0.4	0.7	0.7	0.7	0.7
Progressive ratio test 1 inactive lever presses	0.3	0.4	0.6	-0.7	-0.5	-0.4	0.7	0.4	0.1	0.7	0.6	0.7	0.5	0.7	0.7	0.6	0.7	0.5	0.6
Locomotion velocity, session 2	0.3	0.4	1.4	-0.5	-0.4	-0.7	0.6	0.7	0.4	0.5	0.5	0.6	1.2	0.6	0.7	0.6	0.6	0.6	0.6
Stereotopy head waving duration, day 3	0.3	0.4	1.2	0.5	0.5	0.5	-0.6	-0.5	-0.8	-0.5	-0.5	-0.6	-1.1	-0.6	-0.5	-0.7	-0.7	-0.7	-0.7
Bone: cortical apparent density	0.3	0.3	0.6	-0.6	-0.7	-0.6	0.4	0.6	0.8	0.6	0.6	0.5	0.1	0.5	0.4	0.6	0.6	0.6	0.6
Bone: cortical tissue density	0.3	0.4	0.6	-0.6	-0.7	-0.6	0.5	0.6	0.8	0.6	0.6	0.6	0.1	0.6	0.4	0.7	0.6	0.7	0.6
Distance traveled after self-admin	0.3	0.3	0.8	-0.5	-0.6	-0.9	0.5	0.9	0.6	0.5	0.5	0.5	0.4	0.5	0.6	0.3	0.4	0.5	0.3
Delta time in open arm before/after self-admin	0.3	0.3	0.4	0.5	0.5	-0.4	-0.6	0.4	0.5	-0.5	-0.5	-0.5	-0.4	-0.5	-0.3	-0.6	-0.6	-0.5	-0.6
Active lever presses in extinction session 6	0.3	0.3	0.5	0.5	0.6	0.1	-0.6	-0.1	0.7	-0.5	-0.5	-0.5	-0.6	-0.5	-0.6	-0.6	-0.5	-0.7	-0.5
Delta time to tail flick, test, before/after SA	0.3	0.2	0.4	-0.6	-0.6	-0.3	0.7	0.3	0.0	0.5	0.5	0.6	0.4	0.6	0.6	0.5	0.5	0.4	0.5
Latency to leave start box in cocaine runway, M	0.3	0.3	0.5	-0.6	-0.7	0.4	0.4	-0.4	0.1	0.6	0.6	0.6	0.3	0.6	0.5	0.7	0.6	0.7	0.7
Delay discounting water rate 0 sec	0.2	0.3	0.5	0.5	0.6	0.5	-0.5	-0.5	-0.4	-0.5	-0.6	-0.4	-0.1	-0.4	-0.5	-0.6	-0.5	-0.7	-0.6
Light reinforcement 2	0.2	0.3	0.9	-0.3	-0.3	-0.6	0.4	0.6	0.9	0.3	0.3	0.3	1.0	0.3	0.5	0.4	0.5	0.5	0.4
Reaction time num false alarms AUC	0.2	0.2	0.9	-0.3	-0.4	-0.9	0.3	0.9	0.9	0.3	0.3	0.2	-0.3	0.2	0.3	0.0	0.1	0.1	0.1
Reaction time omissions	0.2	0.3	0.6	-0.6	-0.8	-0.2	0.4	0.2	0.4	0.6	0.6	0.5	-0.7	0.5	0.3	0.5	0.4	0.4	0.6
Pavlov. Cond. magazine entry latency	0.2	0.2	1.8	-0.3	-0.1	-0.4	0.4	0.4	0.1	0.3	0.3	0.4	1.3	0.4	0.5	0.3	0.3	0.3	0.3
Conditioned reinforcement - actives	0.2	0.2	0.6	-0.6	-0.4	-0.2	0.7	0.2	0.4	0.6	0.5	0.6	0.6	0.6	0.6	0.3	0.4	0.3	0.3
Intermittent access terminal intake (last 3 days)	0.2	0.3	1.0	-0.4	-0.2	-1.0	0.5	1.0	0.8	0.4	0.3	0.4	0.4	0.4	0.5	0.1	0.3	0.2	0.1
Intermittent access standard deviation	0.2	0.2	0.5	0.5	0.5	-0.2	-0.3	0.2	-0.7	-0.5	-0.5	-0.5	-0.3	-0.5	-0.3	-0.6	-0.6	-0.6	-0.6
Baseline Anxiety	0.2	0.2	0.4	-0.4	-0.4	-0.5	0.4	0.5	0.6	0.4	0.4	0.4	0.2	0.4	0.6	0.4	0.4	0.4	0.4
One hour access (0.3 mA shock)	0.2	0.3	1.3	-0.4	-0.2	-0.8	0.5	0.8	1.1	0.4	0.3	0.4	0.4	0.4	0.6	0.1	0.2	0.2	0.1
Locomotion velocity, session 7	0.2	0.2	0.4	0.5	0.5	0.1	-0.5	-0.1	0.5	-0.5	-0.5	-0.5	-0.4	-0.5	-0.3	-0.6	-0.6	-0.6	-0.6
Stereotopy head waving duration, day 7	0.2	0.2	0.5	0.5	0.5	0.6	-0.6	-0.6	-0.5	-0.5	-0.5	-0.5	-0.4	-0.5	-0.7	-0.4	-0.4	-0.4	-0.4
Locomotion velocity, session 8	0.2	0.2	0.9	0.6	0.7	0.3	-0.3	-0.3	-0.1	-0.5	-0.6	-0.5	1.0	-0.5	-0.2	-0.4	-0.4	-0.4	-0.4
Locomotion distance, session 8	0.2	0.3	1.2	0.6	0.8	0.0	-0.3	-0.0	0.3	-0.6	-0.6	-0.5	1.1	-0.5	-0.3	-0.4	-0.4	-0.5	-0.4
Condit. Reinf. active minus inactive responses	0.2	0.2	0.9	0.3	0.2	0.2	-0.4	-0.2	-0.4	-0.3	-0.3	-0.3	-0.9	-0.3	-0.4	-0.4	-0.4	-0.4	-0.4
Total locomotion distance, hab. session 1	0.2	0.3	0.4	0.6	0.6	0.6	-0.5	-0.6	-0.3	-0.6	-0.6	-0.6	0.3	-0.6	-0.6	-0.4	-0.5	-0.4	-0.5
Locomotion velocity, hab. session 1	0.2	0.3	0.4	0.6	0.7	0.6	-0.5	-0.6	-0.3	-0.6	-0.6	-0.6	0.3	-0.6	-0.6	-0.5	-0.5	-0.5	-0.5
Total locomotion distance, hab. session 2	0.2	0.3	0.5	0.6	0.7	0.7	-0.5	-0.7	-0.5	-0.6	-0.6	-0.5	0.5	-0.5	-0.6	-0.5	-0.5	-0.4	-0.5
Locomotion velocity, hab. session 2	0.2	0.2	0.4	0.5	0.6	0.6	-0.4	-0.6	-0.4	-0.5	-0.5	-0.4	0.6	-0.4	-0.5	-0.3	-0.3	-0.3	-0.3
Bone: connectivity density	0.2	0.3	1.5	-0.6	-0.7	-0.5	0.5	0.5	1.2	0.5	0.6	0.5	0.1	0.5	0.4	0.5	0.5	0.5	0.5
Bone: cortical area	0.2	0.2	0.7	-0.4	-0.4	-0.9	0.5	0.9	-0.1	0.4	0.4	0.4	0.3	0.4	0.6	0.4	0.4	0.3	0.4
Bone: cortical porosity	0.2	0.2	1.0	-0.4	-0.5	-0.2	0.4	0.2	1.0	0.4	0.4	0.4	-0.6	0.4	0.3	0.3	0.3	0.3	0.3
Bone: trabecular tissue density	0.2	0.3	0.4	0.6	0.6	0.4	-0.6	-0.4	-0.3	-0.6	-0.6	-0.6	-0.3	-0.6	-0.5	-0.5	-0.5	-0.5	-0.5
Delta distance traveled before/after self-admin	0.2	0.2	0.6	-0.4	-0.4	-0.8	0.4	0.8	0.6	0.4	0.4	0.4	0.4	0.4	0.5	0.3	0.3	0.5	0.3
Delta ambulatory time before/after self-admin	0.2	0.3	0.5	0.5	0.6	0.0	-0.6	-0.0	-0.2	-0.5	-0.5	-0.5	-0.4	-0.5	-0.3	-0.7	-0.7	-0.5	-0.7
Weight adjusted by age	0.2	0.2	0.4	0.5	0.5	-0.1	-0.6	0.1	-0.0	-0.5	-0.5	-0.5	-0.4	-0.5	-0.5	-0.6	-0.6	-0.6	-0.6
Locomotion in novel chamber	0.2	0.2	0.3	-0.5	-0.5	0.3	0.3	-0.3	-0.6	0.5	0.4	0.5	0.5	0.5	0.2	0.5	0.5	0.5	0.5
Sr content in liver	0.2	0.1	2.0	0.1	0.3	-0.1	0.1	0.1	0.1	-0.1	-0.1	-0.0	1.4	-0.0	0.1	0.1	0.1	0.1	0.1
Right kidney weight	0.1	0.3	0.6	0.7	0.8	0.2	-0.6	-0.2	0.1	-0.7	-0.7	-0.7	0.6	-0.7	-0.6	-0.4	-0.4	-0.5	-0.4
Liver weight, left	0.1	0.1	0.9	0.2	0.0	0.5	-0.3	-0.5	0.4	-0.2	-0.2	-0.3	-0.9	-0.3	-0.4	-0.2	-0.2	-0.2	-0.2
Extensor digitorum longus weight	0.1	0.6	0.8	-0.8	-0.7	-0.7	0.9	0.7	0.4	0.8	0.8	0.8	0.7	0.8	0.8	0.8	0.8	0.8	0.8
Number of licking bursts	0.1	0.1	0.4	-0.5	-0.4	-0.2	0.5	0.2	-0.2	0.5	0.4	0.4	0.0	0.4	0.6	0.3	0.3	0.3	0.3
Indifference point AUC	0.1	0.1	0.4	0.3	0.5	0.7	-0.4	-0.7	-0.2	-0.3	-0.2	-0.3	-0.0	-0.3	-0.1	-0.0	0.0	-0.2	0.0
Delay discounting total patch changes 6 sec	0.1	0.2	0.3	0.4	0.5	0.4	-0.5	-0.4	0.1	-0.4	-0.4	-0.4	-0.6	-0.4	-0.6	-0.2	-0.3	-0.4	-0.2
Delay discounting time to switch 0 sec	0.1	0.2	0.3	-0.5	-0.5	-0.5	0.4	0.5	0.0	0.5	0.5	0.4	-0.1	0.4	0.5	0.4	0.4	0.6	0.4
Delay discounting water rate 18 sec	0.1	0.1	1.0	0.2	0.3	-0.1	-0.1	0.1	-0.4	-0.1	-0.2	-0.1	1.0	-0.1	0.1	-0.0	0.0	-0.1	-0.0
Reaction time mean minus median	0.1	0.1	0.2	0.2	0.3	0.4	-0.1	-0.4	-0.3	-0.2	-0.2	-0.2	0.3	-0.2	-0.2	-0.2	-0.2	-0.2	-0.2
Reaction time false alarm rate	0.1	0.1	0.3	-0.2	-0.3	-0.5	0.2	0.5	0.5	0.2	0.2	0.1	-0.2	0.1	0.2	0.0	0.1	0.2	0.1
Std. dev. reaction times	0.1	0.2	0.3	0.4	0.3	0.5	-0.2	-0.5	-0.1	-0.4	-0.4	-0.3	-0.3	-0.3	-0.3	-0.5	-0.5	-0.5	-0.5
Pavlov. Cond. index score	0.1	0.2	0.7	0.4	0.6	0.3	-0.2	-0.3	-0.6	-0.3	-0.4	-0.3	0.8	-0.3	-0.1	-0.3	-0.3	-0.3	-0.3
Pavlov. Cond. latency score	0.1	0.1	0.8	0.3	0.5	0.2	-0.1	-0.2	-0.4	-0.3	-0.3	-0.2	0.9	-0.2	-0.0	-0.2	-0.2	-0.2	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	1.0	0.3	0.6	0.2	-0.1	-0.2	-0.5	-0.3	-0.4	-0.2	1.0	-0.2	-0.0	-0.2	-0.2	-0.2	-0.2
Pavlov. Cond. response bias	0.1	0.1	0.8	0.3	0.7	0.3	-0.1	-0.3	-0.4	-0.3	-0.4	-0.2	0.9	-0.2	-0.0	-0.3	-0.3	-0.3	-0.3
Intermittent access intake escalation 2	0.1	0.1	0.6	0.2	0.2	-0.8	-0.0	0.8	-0.1	-0.2	-0.2	-0.1	-0.1	-0.1	-0.1	-0.3	-0.2	-0.2	-0.3
Intermittent access day 1 locomotion	0.1	0.1	0.2	-0.3	-0.2	-0.2	0.3	0.2	0.4	0.3	0.3	0.4	0.3	0.4	0.5	0.2	0.3	0.2	0.2
Total sessions with >9 infusions	0.1	0.1	0.3	-0.2	-0.1	0.1	0.5	-0.1	-0.6	0.2	0.2	0.3	0.1	0.3	0.4	-0.1	0.0	-0.1	-0.1
Short access day 10 total infusions	0.1	0.1	0.2	-0.2	0.0	-0.3	0.3	0.3	0.5	0.2	0.1	0.2	0.4	0.2	0.3	-0.0	-0.0	0.0	-0.0
Short access day 10 total locomotion	0.1	0.1	0.3	0.2	0.2	0.6	-0.1	-0.6	-0.1	-0.2	-0.2	-0.2	-0.1	-0.2	-0.2	-0.3	-0.2	-0.3	-0.3
One hour access (shock baseline)	0.1	0.1	0.6	-0.2	-0.0	-0.8	0.3	0.8	0.6	0.2	0.2	0.3	0.4	0.3	0.4	-0.0	0.1	-0.0	-0.0
Locomotion velocity, session 1	0.1	0.1	0.3	-0.2	-0.1	-0.3	0.4	0.3	0.4	0.2	0.2	0.3	0.5	0.3	0.3	0.2	0.2	0.2	0.2
Locomotion distance, session 2	0.1	0.2	1.8	-0.0	0.2	-0.4	0.3	0.4	0.6	0.1	-0.0	0.2	1.3	0.2	0.3	0.1	0.1	0.0	0.1
Locomotion velocity, session 3	0.1	0.1	0.8	0.4	0.5	-0.1	-0.2	0.1	0.6	-0.3	-0.3	-0.3	0.9	-0.3	-0.1	-0.2	-0.2	-0.2	-0.2
Stereotopy head waving bouts, day 3	0.1	0.1	0.9	0.2	0.2	0.2	-0.2	-0.2	-0.9	-0.2	-0.2	-0.2	-0.4	-0.2	-0.2	-0.3	-0.3	-0.3	-0.3
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	-0.2	-0.3	-0.2	0.2	0.2	0.2	0.2	0.3	0.2	0.0	0.2	0.0	0.4	0.4	0.4	0.4
Incentive salience index mean	0.1	0.1	0.1	-0.2	-0.3	-0.4	0.2	0.4	0.2	0.2	0.2	0.2	0.1	0.2	0.2	0.2	0.2	0.2	0.2
Total zone transitions, hab. session 2	0.1	0.2	1.6	0.3	0.6	-0.1	-0.1	0.1	0.0	-0.3	-0.3	-0.2	1.3	-0.2	-0.0	-0.1	-0.1	-0.1	-0.1
Bone surface	0.1	0.2	0.6	-0.2	-0.2	-0.6	0.4	0.6	0.6	0.2	0.2	0.3	0.8	0.3	0.4	0.3	0.3	0.3	0.3
Bone: cortical porosity	0.1	0.1	0.5	-0.2	-0.3	0.1	0.1	-0.1	0.7	0.2	0.2	0.2	-0.7	0.2	0.0	0.1	0.1	0.1	0.1
Bone: cortical thickness	0.1	0.2	1.1	0.4	0.4	-0.0	-0.3	0.0	-1.1	-0.4	-0.4	-0.4	-0.2	-0.4	-0.3	-0.4	-0.4	-0.4	-0.4
Bone: elastic displacement	0.1	0.1	0.4	0.2	0.2	0.3	-0.2	-0.3	-0.7	-0.2	-0.2	-0.2	-0.2	-0.2	-0.4	-0.3	-0.3	-0.3	-0.3
Bone: endosteal estimation	0.1	0.2	0.4	0.4	0.5	0.3	-0.4	-0.3	0.1	-0.4	-0.4	-0.4	-0.6	-0.4	-0.2	-0.5	-0.5	-0.5	-0.5
Bone: marrow area	0.1	0.2	0.3	0.4	0.5	0.3	-0.5	-0.3	0.1	-0.4	-0.4	-0.4	-0.6	-0.4	-0.2	-0.6	-0.5	-0.6	-0.5
Bone: stiffness	0.1	0.2	0.5	0.4	0.4	0.2	-0.4	-0.2	-0.3	-0.4	-0.4	-0.5	-0.7	-0.5	-0.4	-0.5	-0.4	-0.5	-0.4
Breakpoint value in progressive ratio session	0.1	0.2	0.5	0.3	0.4	0.7	-0.3	-0.7	-0.6	-0.3	-0.3	-0.3	-0.4	-0.3	-0.3	-0.3	-0.2	-0.4	-0.3
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.4	-0.3	-0.1	0.5	0.1	0.0	0.4	0.3	0.4	0.3	0.4	0.3	0.2	0.3	0.2	0.3
Time in closed arm after self-admin	0.1	0.1	0.6	0.1	0.1	0.2	0.0	-0.2	-0.8	-0.1	-0.2	-0.1	-0.1	-0.1	-0.2	-0.2	-0.1	-0.2	-0.2
Time to tail flick, test, before self-admin	0.1	0.1	0.2	0.2	0.3	0.2	-0.4	-0.2	0.3	-0.2	-0.2	-0.2	-0.0	-0.2	-0.4	0.1	-0.1	0.0	0.2
Time to tail flick, test, after self-admin	0.1	0.1	0.4	-0.4	-0.3	-0.1	0.4	0.1	0.0	0.4	0.4	0.4	0.3	0.4	0.2	0.6	0.4	0.4	0.6
Ambulatory time before self-admin	0.1	0.1	0.3	-0.3	-0.3	-0.5	0.3	0.5	0.2	0.2	0.3	0.2	0.1	0.2	0.4	0.3	0.3	0.3	0.3
Ambulatory time after self-admin	0.1	0.1	0.4	-0.1	-0.2	-0.7	0.2	0.7	0.5	0.1	0.2	0.1	0.1	0.1	0.3	0.1	0.1	0.2	0.1
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	-0.2	-0.1	0.3	0.2	-0.3	0.1	0.2	0.2	0.2	0.3	0.2	0.1	0.3	0.3	0.3	0.3
Change in fecal boli incidents, locomotor task	0.1	0.1	0.6	0.1	0.1	0.8	-0.1	-0.8	-0.6	-0.1	-0.1	-0.1	-0.2	-0.1	-0.1	-0.3	-0.2	-0.2	-0.2
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.4	-0.3	-0.6	-0.3	0.3	0.3	0.5	0.3	0.4	0.3	0.1	0.3	0.3	0.2	0.4	0.3	0.1
Total resting periods, locomotor time 1	0.1	0.1	0.4	0.1	0.1	0.6	-0.1	-0.6	-0.4	-0.1	-0.1	-0.1	-0.2	-0.1	-0.0	-0.3	-0.0	-0.1	-0.3
Total resting periods, locomotor time 2	0.1	0.1	0.3	-0.2	0.1	-0.4	0.2	0.4	0.1	0.2	0.2	0.2	0.3	0.2	0.5	0.3	0.1	0.2	0.3
Rest time, locomotor task time 2	0.1	0.1	0.1	-0.2	-0.2	0.4	0.2	-0.4	-0.3	0.2	0.2	0.2	-0.0	0.2	0.4	0.2	-0.0	0.4	0.3
Vertical activity count, locomotor time 2	0.1	0.1	0.2	0.3	0.4	-0.1	-0.2	0.1	0.1	-0.3	-0.3	-0.3	0.0	-0.3	-0.5	-0.2	0.0	-0.4	-0.2
Co content in liver	0.1	0.1	0.6	0.1	-0.0	-0.8	-0.0	0.8	0.4	-0.1	-0.1	-0.1	-0.2	-0.1	0.1	-0.3	-0.3	-0.2	-0.3
Mg content in liver	0.1	0.1	1.5	0.1	0.3	0.0	0.1	-0.0	0.0	-0.1	-0.1	0.0	1.2	0.0	0.2	0.1	0.1	0.1	0.1
Se content in liver	0.1	0.1	0.2	0.2	0.3	0.4	-0.2	-0.4	-0.5	-0.2	-0.1	-0.2	0.3	-0.2	-0.2	0.2	0.1	0.0	0.1
Tibialis anterior weight	0.0	0.0	0.2	0.2	0.3	0.1	-0.0	-0.1	-0.4	-0.2	-0.2	-0.1	0.2	-0.1	-0.1	-0.1	-0.1	-0.2	-0.1
Water consumed over 24 hours	0.0	0.0	0.2	-0.0	0.0	-0.2	0.1	0.2	-0.4	0.1	0.0	0.1	0.4	0.1	-0.0	0.1	0.1	0.1	0.1
Reaction time mean	0.0	0.0	0.1	0.1	0.2	0.3	-0.1	-0.3	-0.0	-0.1	-0.1	-0.1	-0.3	-0.1	-0.2	-0.2	-0.3	-0.3	-0.2
Reaction time mean AUC	0.0	0.0	0.1	0.0	0.1	0.2	0.0	-0.2	0.2	-0.0	-0.0	-0.0	-0.2	-0.0	-0.1	-0.1	-0.2	-0.2	-0.1
Median of all reaction times	0.0	0.0	0.3	0.1	0.2	0.1	-0.1	-0.1	0.1	-0.1	-0.1	-0.1	-0.5	-0.1	-0.2	-0.2	-0.3	-0.4	-0.2
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.1	-0.2	-0.2	0.1	0.2	0.2	0.1	0.1	0.1	-0.1	0.1	-0.1	-0.0	-0.0	-0.0	-0.0
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	-0.0	0.1	-0.1	0.1	0.1	0.2	0.0	0.0	0.1	0.3	0.1	-0.0	0.1	0.1	0.1	0.1
Intermitt. access escalation Index	0.0	0.0	0.5	0.0	0.1	-0.2	-0.1	0.2	0.7	-0.0	-0.0	-0.0	0.0	-0.0	0.1	-0.1	-0.0	-0.1	-0.1
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.1	0.0	-0.1	0.2	0.1	0.3	0.1	0.1	0.2	0.2	0.2	0.2	0.0	0.1	0.1	0.0
Progressive ratio test 1 active lever presses	0.0	0.0	0.2	-0.1	0.1	-0.0	0.1	0.0	0.4	0.1	0.0	0.1	0.1	0.1	0.2	-0.1	0.0	-0.1	-0.1
Progressive ratio test 1 breakpoint	0.0	0.0	0.2	-0.2	-0.1	-0.1	0.2	0.1	0.5	0.2	0.1	0.2	0.2	0.2	0.3	0.0	0.1	0.1	0.0
Short access day 10 total inactive lever presses	0.0	0.0	0.2	-0.1	-0.1	-0.2	0.2	0.2	-0.5	0.1	0.1	0.1	0.1	0.1	0.1	0.2	0.2	0.3	0.2
Short access day 1 locomotion	0.0	0.0	0.2	-0.2	-0.1	0.2	0.4	-0.2	-0.1	0.2	0.2	0.2	0.3	0.2	0.2	0.1	0.2	0.1	0.1
Short access total locomotion	0.0	0.0	0.2	-0.1	0.0	0.5	0.2	-0.5	0.0	0.1	0.0	0.1	0.2	0.1	0.0	-0.1	0.0	-0.1	-0.1
Compulsive drug intake	0.0	0.0	0.5	-0.1	-0.1	-0.0	0.1	0.0	0.7	0.1	0.1	0.1	0.0	0.1	0.2	0.2	0.1	0.2	0.2
Context. condit. distance diff. score	0.0	0.0	0.0	0.0	0.0	-0.2	0.0	0.2	-0.0	-0.0	-0.0	-0.0	0.0	-0.0	0.0	-0.0	0.0	-0.0	0.0
Degree of sensitization stereotypy	0.0	0.0	0.1	0.1	-0.1	0.2	-0.2	-0.2	0.1	-0.1	-0.0	-0.1	-0.3	-0.1	-0.4	0.2	0.2	0.2	0.2
Condit. Reinf. active responses	0.0	0.0	0.2	-0.2	-0.3	-0.3	0.0	0.3	-0.0	0.2	0.2	0.1	-0.4	0.1	0.1	0.2	0.2	0.2	0.2
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.2	0.1	0.1	-0.2	-0.1	0.3	-0.2	-0.2	-0.2	-0.4	-0.2	-0.2	-0.2	-0.2	-0.2	-0.2
Bone: apparent density	0.0	0.0	0.2	0.2	0.2	0.1	-0.1	-0.1	0.4	-0.2	-0.2	-0.2	0.0	-0.2	-0.1	-0.2	-0.2	-0.2	-0.2
Bone volume	0.0	0.1	0.4	-0.1	-0.0	-0.4	0.2	0.4	0.5	0.1	0.1	0.1	0.6	0.1	0.2	0.1	0.1	0.1	0.1
Bone: cortical thickness	0.0	0.0	0.0	0.1	0.1	0.0	-0.0	-0.0	-0.1	-0.1	-0.1	-0.1	-0.1	-0.1	0.0	-0.1	-0.1	-0.1	-0.1
Bone: periosteal estimation	0.0	0.0	0.1	0.1	0.3	-0.3	-0.1	0.3	0.0	-0.1	-0.1	-0.1	-0.1	-0.1	0.1	-0.2	-0.2	-0.2	-0.2
Bone: post-yield work	0.0	0.0	0.1	0.2	0.3	-0.0	-0.1	0.0	0.0	-0.2	-0.2	-0.2	0.0	-0.2	-0.0	-0.2	-0.2	-0.2	-0.2
Bone: trabecular thickness	0.0	0.0	0.3	0.2	0.2	0.2	-0.1	-0.2	0.3	-0.2	-0.2	-0.1	0.5	-0.1	-0.2	-0.0	-0.0	-0.0	-0.0
Distance traveled before self-admin	0.0	0.0	0.0	0.1	0.0	-0.2	-0.0	0.2	0.0	-0.1	-0.1	-0.1	-0.1	-0.1	0.0	-0.1	-0.0	-0.1	-0.1
Diff in mean of infusions in LGA sessions	0.0	0.0	0.6	-0.1	-0.0	0.2	0.1	-0.2	-0.8	0.1	0.1	0.1	-0.1	0.1	0.1	-0.0	0.1	0.0	0.0
Extinction: sum of active levers before priming	0.0	0.0	0.1	0.1	0.2	0.3	-0.0	-0.3	-0.0	-0.1	-0.1	-0.1	-0.3	-0.1	0.0	-0.1	-0.1	-0.2	-0.1
Bouts of movement, locomotor time 1	0.0	0.1	0.2	0.1	0.1	0.5	-0.1	-0.5	-0.3	-0.1	-0.1	-0.1	-0.2	-0.1	-0.1	-0.3	-0.0	-0.1	-0.3
Bouts of movement, locomotor time 2	0.0	0.0	0.1	0.1	0.3	-0.2	-0.1	0.2	-0.1	-0.1	-0.1	-0.1	0.1	-0.1	0.2	-0.0	-0.1	-0.1	0.0

For each tested trait, stats based on TWAS chi² (squared Z-score) for the above models are shown. Avg chi² ratio is the mean chi² across all models for this gene, divided by the mean chi² across all models for all genes. Avg chi² is the mean chi² across all models for this gene. Max chi² is the highest chi² across all models for this gene.

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.