Hub : Traits : body_g : ← →

chr18:25,166,673-27,022,191

Best TWAS P=1.510247e-10 · Best GWAS P=3.340299e-10 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Reep5	alternative polyA	ENSRNOT00000027345	0.11	0.11	blup	1161	0.11	2.3e-12	5.1	-5.2	2.1e-07	-0.94	0.39	0.61	FALSE
2	Adipose	Reep5	alternative polyA	ENSRNOT00000108864	0.11	0.12	top1	1	0.12	6.8e-13	5.2	5.2	1.9e-07	0.96	0.99	0.01	FALSE
3	Adipose	Cdc23	alternative polyA	ENSRNOT00000037888	0.17	0.12	top1	1	0.12	1.2e-13	6.2	6.2	4.8e-10	0.98	0.21	0.79	FALSE
4	Adipose	Cdc23	alternative polyA	ENSRNOT00000101231	0.16	0.11	lasso	37	0.12	7.2e-13	5.9	-5.2	2.1e-07	0.89	0.32	0.68	TRUE
5	Adipose	Cdc23	alternative polyA	ENSRNOT00000101231	0.05	0.03	top1	1	0.03	2.9e-04	5.1	-5.1	2.7e-07	-0.93	0.09	0.03	FALSE
6	Adipose	Cdc23	alternative polyA	ENSRNOT00000114348	0.05	0.03	top1	1	0.03	3.5e-04	5.1	5.1	2.7e-07	0.93	0.08	0.03	FALSE
7	Adipose	Fam13b	gene expression	ENSRNOG00000020384	0.14	0.15	enet	22	0.15	1.7e-16	5.5	5.4	8.4e-08	0.97	0.40	0.60	FALSE
8	Adipose	Cdc23	gene expression	ENSRNOG00000024241	0.05	0.03	blup	835	0.03	1.1e-04	4.8	6.0	2.3e-09	0.98	0.32	0.67	FALSE
9	Adipose	Reep5	isoform ratio	ENSRNOT00000027345	0.11	0.12	top1	1	0.12	1.1e-13	5.2	-5.2	1.9e-07	-0.97	0.99	0.01	FALSE
10	Adipose	Reep5	isoform ratio	ENSRNOT00000108864	0.10	0.12	top1	1	0.12	3.9e-13	5.2	5.2	1.9e-07	0.97	0.99	0.01	FALSE
11	Adipose	Cdc23	isoform ratio	ENSRNOT00000037888	0.03	0.01	blup	835	0.02	4.9e-03	6.2	6.0	1.9e-09	1.00	0.26	0.54	FALSE
12	Adipose	Cdc23	isoform ratio	ENSRNOT00000101231	0.14	0.10	blup	835	0.11	2.3e-12	5.9	-5.9	3.8e-09	-0.95	0.32	0.68	FALSE
13	Adipose	Fam13b	intron excision ratio	chr18:26065107:26067320	0.02	0.03	top1	1	0.03	1.6e-04	5.1	-5.1	2.7e-07	-0.99	0.05	0.03	FALSE
14	Adipose	Fam13b	mRNA stability	ENSRNOG00000020384	0.10	0.13	top1	1	0.13	1.3e-14	5.4	5.4	7.0e-08	0.98	0.97	0.03	FALSE
15	Adipose	Cdc23	mRNA stability	ENSRNOG00000024241	0.06	0.04	blup	835	0.04	1.5e-05	5.2	5.8	6.8e-09	0.93	0.32	0.67	FALSE
16	BLA	Reep5	alternative polyA	ENSRNOT00000027345	0.16	0.20	enet	66	0.21	2.6e-11	4.7	-5.3	1.3e-07	-0.98	0.31	0.69	FALSE
17	BLA	Cdc23	alternative polyA	ENSRNOT00000101231	0.13	0.12	lasso	21	0.13	3.3e-07	6.1	-6.1	9.8e-10	-0.99	0.29	0.71	FALSE
18	BLA	Reep5	gene expression	ENSRNOG00000020167	0.15	0.14	top1	1	0.14	3.9e-08	6.1	6.1	9.8e-10	0.98	0.34	0.64	FALSE
19	BLA	Reep5	isoform ratio	ENSRNOT00000027345	0.19	0.24	lasso	31	0.25	1.6e-13	5.0	-5.2	1.7e-07	-0.99	0.29	0.71	FALSE
20	BLA	Cdc23	isoform ratio	ENSRNOT00000101231	0.10	0.08	blup	835	0.09	1.6e-05	6.1	-6.0	2.5e-09	-1.00	0.30	0.70	FALSE
21	BLA	Reep5	intron excision ratio	chr18:25947663:25949991	0.06	0.05	top1	1	0.04	1.9e-03	6.1	-6.1	8.8e-10	-0.98	0.05	0.05	FALSE
22	BLA	Reep5	intron excision ratio	chr18:25950159:25957916	0.08	0.06	top1	1	0.06	2.3e-04	6.1	6.1	8.8e-10	0.98	0.06	0.07	FALSE
23	BLA	Reep5	mRNA stability	ENSRNOG00000020167	0.05	0.00	blup	1162	0.02	4.6e-02	4.6	5.7	1.4e-08	0.91	0.26	0.41	FALSE
24	Brain	Reep5	alternative polyA	ENSRNOT00000027345	0.07	0.07	top1	1	0.07	7.0e-07	6.1	-6.1	1.0e-09	-0.95	0.34	0.62	FALSE
25	Brain	Reep5	alternative polyA	ENSRNOT00000108864	0.06	0.06	top1	1	0.06	1.5e-06	6.1	6.1	1.0e-09	0.95	0.32	0.59	FALSE
26	Brain	Cdc23	alternative polyA	ENSRNOT00000037888	0.08	0.07	blup	835	0.07	2.0e-07	5.2	5.9	3.9e-09	0.99	0.36	0.64	FALSE
27	Brain	Cdc23	alternative polyA	ENSRNOT00000101231	0.08	0.09	blup	835	0.10	3.6e-09	6.0	-6.0	1.8e-09	-0.99	0.30	0.70	FALSE
28	Brain	Cdc23	alternative polyA	ENSRNOT00000101231	0.03	0.01	blup	835	0.02	8.4e-03	4.7	-5.3	9.3e-08	-0.84	0.31	0.38	FALSE
29	Brain	Cdc23	alternative polyA	ENSRNOT00000114348	0.03	0.01	blup	835	0.02	8.8e-03	4.7	5.3	9.4e-08	0.84	0.30	0.38	FALSE
30	Brain	Brd8	gene expression	ENSRNOG00000020340	0.02	0.03	top1	1	0.03	8.8e-04	5.2	5.2	1.8e-07	0.97	0.08	0.03	FALSE
31	Brain	Cdc23	gene expression	ENSRNOG00000024241	0.03	0.03	top1	1	0.03	5.8e-04	6.3	6.3	3.8e-10	0.95	0.05	0.18	FALSE
32	Brain	Cdc23	isoform ratio	ENSRNOT00000101231	0.08	0.08	blup	835	0.10	3.8e-09	6.2	-6.0	2.6e-09	-0.96	0.29	0.71	FALSE
33	Brain	Reep5	intron excision ratio	chr18:25947663:25949991	0.03	0.02	top1	1	0.02	7.1e-03	6.1	-6.1	1.1e-09	-0.97	0.04	0.04	FALSE
34	Brain	Reep5	intron excision ratio	chr18:25950159:25957916	0.03	0.03	blup	1162	0.03	1.6e-03	6.1	5.1	3.3e-07	0.97	0.35	0.64	FALSE
35	Brain	Apc	intron excision ratio	chr18:25828942:25871423	0.05	0.07	enet	112	0.07	2.5e-07	6.2	5.8	8.1e-09	0.99	0.31	0.69	FALSE
36	Brain	Apc	intron excision ratio	chr18:25864409:25871423	0.07	0.02	blup	1199	0.02	7.0e-03	6.1	5.7	9.9e-09	0.94	0.30	0.55	FALSE
37	Brain	Apc	intron excision ratio	chr18:25869365:25871423	0.02	0.02	blup	1199	0.03	1.7e-03	4.0	-5.2	2.3e-07	-0.97	0.39	0.57	FALSE
38	Brain	Cdc23	intron excision ratio	chr18:26240165:26240396	0.03	0.03	top1	1	0.03	1.1e-03	5.5	-5.5	4.8e-08	-0.98	0.04	0.03	FALSE
39	Brain	Cdc23	mRNA stability	ENSRNOG00000024241	0.02	0.00	blup	835	0.01	4.2e-02	6.1	5.8	8.6e-09	0.92	0.25	0.50	FALSE
40	Eye	Fam13b	gene expression	ENSRNOG00000020384	0.57	0.11	enet	578	0.24	1.5e-04	4.9	5.6	2.3e-08	0.65	0.21	0.30	TRUE
41	Eye	Apc	isoform ratio	ENSRNOT00000102176	0.28	0.11	top1	1	0.11	9.7e-03	5.8	5.8	5.8e-09	0.98	0.07	0.06	FALSE
42	IL	Cdc23	alternative polyA	ENSRNOT00000037888	0.27	0.03	top1	1	0.03	7.0e-02	6.2	6.2	6.0e-10	0.99	0.04	0.06	FALSE
43	IL	Brd8	gene expression	ENSRNOG00000020340	0.20	0.08	top1	1	0.08	7.2e-03	6.2	6.2	7.6e-10	0.97	0.05	0.06	FALSE
44	IL	Cdc23	isoform ratio	ENSRNOT00000101231	0.17	0.01	blup	834	0.03	7.3e-02	6.2	-6.0	2.6e-09	-0.95	0.17	0.30	FALSE
45	LHb	Cdc23	alternative polyA	ENSRNOT00000101231	0.21	0.05	top1	1	0.05	2.7e-02	5.5	-5.5	4.0e-08	-0.97	0.04	0.05	FALSE
46	LHb	Cdc23	gene expression	ENSRNOG00000024241	0.29	0.15	top1	1	0.15	1.8e-04	6.2	6.2	7.6e-10	0.92	0.05	0.07	TRUE
47	LHb	Cdc23	isoform ratio	ENSRNOT00000101231	0.18	0.06	top1	1	0.06	1.3e-02	6.2	-6.2	5.1e-10	-0.96	0.04	0.06	FALSE
48	LHb	Cdc23	mRNA stability	ENSRNOG00000024241	0.23	0.12	top1	1	0.12	9.7e-04	6.2	6.2	7.6e-10	0.95	0.05	0.06	FALSE
49	Liver	Cdc23	alternative polyA	ENSRNOT00000037888	0.15	0.10	blup	835	0.11	5.0e-12	5.9	6.0	2.0e-09	1.00	0.32	0.68	FALSE
50	Liver	Cdc23	alternative polyA	ENSRNOT00000101231	0.17	0.11	blup	835	0.12	2.2e-13	5.9	-6.0	2.4e-09	-1.00	0.32	0.68	FALSE
51	Liver	Cdc23	alternative polyA	ENSRNOT00000101231	0.05	0.04	top1	1	0.04	2.1e-05	5.5	-5.5	4.5e-08	-0.97	0.15	0.03	FALSE
52	Liver	Cdc23	alternative polyA	ENSRNOT00000114348	0.05	0.04	top1	1	0.04	3.4e-05	5.5	5.5	4.5e-08	0.96	0.10	0.03	FALSE
53	Liver	Srp19	gene expression	ENSRNOG00000020204	0.04	0.02	blup	1227	0.02	3.9e-03	4.9	6.0	1.8e-09	0.94	0.36	0.54	FALSE
54	Liver	Fam13b	gene expression	ENSRNOG00000020384	0.14	0.11	blup	1001	0.13	2.8e-14	4.9	6.1	1.4e-09	0.95	0.39	0.61	FALSE
55	Liver	Cdc23	gene expression	ENSRNOG00000024241	0.19	0.13	blup	835	0.14	6.0e-15	6.2	6.0	2.4e-09	1.00	0.32	0.68	FALSE
56	Liver	Pkd2l2	gene expression	ENSRNOG00000025489	0.03	0.02	top1	1	0.02	1.3e-03	6.2	6.2	4.8e-10	0.99	0.04	0.06	FALSE
57	Liver	Gfra3	isoform ratio	ENSRNOT00000114917	0.03	0.01	lasso	1	0.02	4.7e-03	5.8	-5.8	6.6e-09	-0.96	0.23	0.54	FALSE
58	Liver	Cdc23	isoform ratio	ENSRNOT00000037888	0.04	0.03	top1	1	0.03	5.5e-04	5.5	5.5	4.5e-08	0.97	0.05	0.03	FALSE
59	Liver	Cdc23	isoform ratio	ENSRNOT00000101231	0.20	0.13	blup	835	0.15	7.8e-16	5.9	-6.0	2.1e-09	-0.99	0.32	0.68	FALSE
60	Liver	Srp19	intron excision ratio	chr18:25931783:25935915	0.03	0.02	blup	1227	0.02	1.8e-03	5.2	-5.6	2.1e-08	-0.98	0.43	0.54	FALSE
61	Liver	NA	intron excision ratio	chr18:25931783:25935915	0.03	0.02	blup	1227	0.02	1.8e-03	5.2	-5.6	2.1e-08	-0.98	0.43	0.54	FALSE
62	Liver	Reep5	mRNA stability	ENSRNOG00000020167	0.05	0.04	top1	1	0.04	9.1e-06	6.2	6.2	4.8e-10	0.97	0.18	0.69	FALSE
63	Liver	Cdc23	mRNA stability	ENSRNOG00000024241	0.04	0.02	lasso	16	0.03	5.7e-04	6.2	6.2	4.7e-10	0.98	0.30	0.64	FALSE
64	NAcc	Cdc23	alternative polyA	ENSRNOT00000037888	0.23	0.06	enet	8	0.07	1.5e-02	6.2	5.3	9.2e-08	0.27	0.27	0.42	FALSE
65	NAcc	Cdc23	alternative polyA	ENSRNOT00000101231	0.27	0.05	blup	834	0.10	2.7e-03	6.1	-5.8	5.7e-09	-0.93	0.28	0.53	FALSE
66	NAcc	Reep5	gene expression	ENSRNOG00000020167	0.41	0.13	blup	1159	0.13	6.6e-04	6.2	6.4	1.5e-10	0.94	0.32	0.54	TRUE
67	NAcc	Reep5	isoform ratio	ENSRNOT00000027345	0.21	0.04	blup	1159	0.09	6.1e-03	6.2	-5.4	7.6e-08	-0.98	0.31	0.44	FALSE
68	NAcc	Reep5	isoform ratio	ENSRNOT00000108864	0.18	0.03	blup	1159	0.06	2.3e-02	6.2	5.3	1.2e-07	0.97	0.28	0.37	FALSE
69	NAcc2	Reep5	alternative polyA	ENSRNOT00000027345	0.11	0.10	lasso	34	0.12	5.5e-07	4.7	-5.4	5.6e-08	0.97	0.30	0.70	FALSE
70	NAcc2	Cdc23	alternative polyA	ENSRNOT00000037888	0.06	0.03	top1	1	0.03	9.1e-03	5.2	5.2	1.8e-07	0.99	0.06	0.04	FALSE
71	NAcc2	Cdc23	alternative polyA	ENSRNOT00000101231	0.10	0.06	top1	1	0.06	2.1e-04	6.0	-6.0	1.5e-09	-1.00	0.14	0.18	FALSE
72	NAcc2	Pkd2l2	gene expression	ENSRNOG00000025489	0.04	0.05	enet	22	0.05	7.7e-04	6.1	6.1	8.6e-10	1.00	0.32	0.61	FALSE
73	NAcc2	Cdc23	isoform ratio	ENSRNOT00000101231	0.09	0.07	top1	1	0.07	2.0e-04	5.2	-5.2	1.8e-07	-1.00	0.16	0.04	FALSE
74	OFC	Reep5	isoform ratio	ENSRNOT00000027345	0.90	0.02	top1	1	0.03	8.5e-02	5.5	-5.5	4.0e-08	-0.95	0.06	0.05	FALSE
75	PL	Reep5	alternative polyA	ENSRNOT00000108864	0.22	0.07	blup	1161	0.08	4.9e-03	6.1	5.1	2.9e-07	0.97	0.31	0.43	FALSE
76	PL	Reep5	gene expression	ENSRNOG00000020167	0.28	0.15	top1	1	0.15	1.7e-04	6.2	6.2	4.7e-10	0.97	0.07	0.09	FALSE
77	PL	Epb41l4a	gene expression	ENSRNOG00000026050	0.16	0.03	blup	1033	0.03	6.4e-02	3.6	5.4	5.7e-08	0.95	0.26	0.28	TRUE
78	PL	Reep5	isoform ratio	ENSRNOT00000027345	0.18	0.08	top1	1	0.08	5.6e-03	6.2	-6.2	4.7e-10	-0.97	0.06	0.06	FALSE
79	PL	Reep5	isoform ratio	ENSRNOT00000108864	0.20	0.08	top1	1	0.08	5.5e-03	6.1	6.1	8.8e-10	0.97	0.06	0.06	FALSE
80	PL2	Cdc23	alternative polyA	ENSRNOT00000037888	0.07	0.03	top1	1	0.03	7.8e-03	6.1	6.1	8.8e-10	0.98	0.04	0.05	FALSE
81	PL2	Cdc23	alternative polyA	ENSRNOT00000101231	0.08	0.04	top1	1	0.04	3.0e-03	6.1	-6.1	8.8e-10	-0.99	0.04	0.06	FALSE
82	PL2	Reep5	gene expression	ENSRNOG00000020167	0.10	0.08	blup	1162	0.09	9.1e-06	4.7	6.3	2.4e-10	0.96	0.32	0.67	FALSE
83	PL2	Brd8	gene expression	ENSRNOG00000020340	0.05	0.02	blup	912	0.02	2.9e-02	6.1	5.8	6.5e-09	0.99	0.26	0.51	FALSE
84	PL2	Apc	isoform ratio	ENSRNOT00000027691	0.06	0.04	blup	1186	0.05	1.0e-03	5.2	-5.5	4.2e-08	-0.99	0.32	0.65	FALSE
85	PL2	Apc	isoform ratio	ENSRNOT00000102176	0.06	0.04	blup	1186	0.05	1.3e-03	6.1	5.6	2.2e-08	0.99	0.32	0.65	FALSE
86	PL2	Apc	intron excision ratio	chr18:25855715:25856649	0.07	0.04	blup	1186	0.06	5.7e-04	6.1	-6.0	2.4e-09	-0.98	0.29	0.66	TRUE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.