Hub : Genes

Pcsk2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression ENSRNOG00000005438 0.11 0.08 1.3e-04 0.07 0.04 0.05 0.06 1.9e-04 2.8e-03 9.7e-04 3.6e-04
2 BLA mRNA stability ENSRNOG00000005438 0.23 0.12 3.9e-09 0.15 0 0.12 0 3.1e-08 2.8e-01 6.2e-07 2.1e-01
3 Brain gene expression ENSRNOG00000005438 0.38 0.13 0.0e+00 0.44 0.41 0.43 0.26 3.9e-44 6.3e-41 1.1e-42 1.5e-23
4 Brain mRNA stability ENSRNOG00000005438 0.25 0.13 1.7e-05 0.06 0.06 0.03 0.06 1.1e-06 3.0e-06 6.8e-04 3.1e-06
5 IL gene expression ENSRNOG00000005438 0.49 0.24 3.7e-06 0.21 0.16 0.14 0.18 7.5e-06 1.1e-04 3.6e-04 4.1e-05
6 NAcc gene expression ENSRNOG00000005438 0.25 0.21 6.7e-10 0.15 0.1 0.14 0.15 5.2e-11 1.0e-07 1.2e-10 3.4e-11
7 OFC gene expression ENSRNOG00000005438 0.62 0.16 3.1e-12 0.36 0.38 0.34 0.38 2.6e-09 7.1e-10 5.2e-09 5.0e-10
8 PL gene expression ENSRNOG00000005438 0.15 0.08 2.9e-15 0.16 0.14 0.18 0.1 7.2e-12 1.9e-10 1.0e-13 3.2e-08
9 PL mRNA stability ENSRNOG00000005438 0.04 0.03 3.3e-03 0.02 0.02 0.02 0.01 5.4e-03 6.6e-03 8.1e-03 8.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
BMI with tail10.433.646.16.4-6.06.1-0.46.86.05.46.4-6.1
BMI without tail9.319.524.64.8-4.34.9-1.45.04.93.74.8-4.7
Body weight12.954.471.47.8-8.07.8-1.88.37.46.28.4-8.1
Epididymis fat weight10.524.532.25.2-5.45.5-1.65.75.03.85.5-5.4
Glucose2.13.34.41.7-2.12.1-1.81.81.90.81.9-1.9
Heart weight2.43.46.72.0-1.52.6-1.01.52.11.92.0-1.6
Left kidney weight2.05.67.92.7-2.52.8-0.82.52.52.22.6-2.2
Right kidney weight1.64.77.32.6-2.32.7-0.91.92.11.82.4-2.2
Tail length0.82.54.71.3-1.31.7-2.21.41.40.41.7-2.0
Length with tail2.48.812.72.9-3.13.3-2.03.12.81.83.6-3.5
Length without tail1.83.96.21.9-2.41.9-0.32.21.61.72.5-2.2
Liver weight, left0.30.40.70.7-0.80.6-0.20.80.4-0.00.8-0.8
Liver weight, right0.30.61.30.7-0.60.90.11.00.50.01.1-0.9
Parametrial fat weight16.832.843.25.8-6.45.8-1.86.35.75.26.4-6.6
Retroperitoneal fat weight20.668.186.78.6-8.98.9-1.19.08.67.49.3-9.1
Intraocular pressure0.50.72.6-0.8-0.2-0.5-1.4-0.7-0.6-1.6-0.30.3
Extensor digitorum longus weight0.41.72.91.3-1.61.0-0.91.41.30.91.2-1.7
Soleus weight0.20.51.10.6-1.00.6-0.50.70.60.20.7-1.0
Tibialis anterior weight1.65.67.92.8-2.32.7-0.32.82.61.92.5-2.3
Tibia length3.39.213.63.2-3.33.4-1.13.23.02.43.7-3.2
Number of licking bursts0.20.21.0-0.3-0.2-0.61.0-0.1-0.60.2-0.20.3
Food consumed during 24 hour testing period0.20.30.70.4-0.80.3-0.30.50.20.50.8-0.7
Times rat made contact with spout1.51.83.81.0-1.41.1-1.01.01.22.01.2-1.7
Mean time between licks in bursts0.30.41.1-0.50.5-0.50.7-0.5-0.8-1.1-0.30.6
Mean num. licks in bursts1.01.23.10.9-0.61.2-1.80.61.10.81.0-1.3
Std. dev. time between licks in bursts0.81.01.7-1.00.6-1.20.6-1.0-1.3-1.1-1.01.0
Water consumed over 24 hours0.30.43.0-0.1-0.1-0.1-1.7-0.1-0.10.10.2-0.5
Indifference point 0 sec0.81.36.6-0.80.4-1.0-2.6-0.9-1.0-1.1-0.60.3
Indifference point AUC1.31.62.2-1.11.0-1.41.0-1.4-1.4-0.9-1.51.4
Indifference point function ln k0.50.73.20.0-0.9-0.0-1.80.60.2-0.30.7-1.2
Indifference point function log k0.50.73.20.0-0.9-0.0-1.80.60.2-0.30.7-1.2
Delay discounting total patch changes 0 sec1.01.65.2-1.10.6-1.3-2.3-1.3-1.3-1.2-0.90.6
Delay discounting total patch changes 12 sec0.10.10.30.3-0.20.2-0.6-0.00.10.60.2-0.5
Delay discounting total patch changes 18 sec1.82.43.7-1.51.8-1.5-0.8-1.9-1.5-1.5-1.71.7
Delay discounting total patch changes 24 sec0.50.71.4-0.61.1-0.7-0.3-1.2-0.6-0.5-1.01.0
Delay discounting total patch changes 6 sec0.30.50.6-0.60.6-0.6-0.8-0.7-0.7-0.7-0.70.6
Delay discounting time to switch 0 sec2.43.76.42.1-1.32.50.41.92.32.02.2-1.7
Delay discounting water rate 0 sec2.43.86.2-2.01.8-2.30.2-2.1-2.0-1.8-2.51.9
Delay discounting water rate 12 sec3.35.07.4-2.22.7-2.21.4-2.3-2.0-1.9-2.72.5
Delay discounting water rate 18 sec6.18.110.5-3.13.0-2.9-0.4-2.9-2.9-3.2-3.12.9
Delay discounting water rate 24 sec3.54.96.6-2.62.4-2.4-0.7-2.4-2.0-2.1-2.62.1
Delay discounting water rate 6 sec2.63.87.6-1.72.3-1.70.4-1.8-1.8-2.8-2.22.1
Locomotor activity0.40.60.90.8-0.90.8-0.10.90.90.70.5-0.6
Locomotor testing distance0.10.10.5-0.20.2-0.30.1-0.3-0.3-0.3-0.70.5
Locomotor testing rearing0.10.20.4-0.20.5-0.40.4-0.2-0.40.1-0.60.4
Light reinforcement 10.50.82.5-0.90.5-1.0-1.6-1.0-1.1-0.4-0.70.2
Light reinforcement 20.70.94.0-0.90.3-1.1-2.0-0.5-1.0-0.4-0.60.1
Reaction time number correct0.40.61.1-0.90.9-0.7-0.8-0.5-0.5-1.1-0.70.5
Reaction time mean minus median1.92.54.31.5-2.11.5-1.01.41.21.31.8-2.0
Reaction time mean minus median AUC1.52.04.01.2-2.01.0-1.21.40.71.11.6-2.0
Reaction time num false alarms2.23.04.7-2.01.3-2.0-0.4-2.2-2.1-1.7-1.61.7
Reaction time num false alarms AUC2.02.84.3-1.81.3-1.9-0.1-2.1-2.0-1.5-1.61.7
Reaction time trials correct on left0.40.61.1-0.90.9-0.7-0.8-0.5-0.5-1.1-0.70.5
Reaction time trials on left0.40.51.1-0.80.8-0.7-0.8-0.5-0.5-1.0-0.70.5
Reaction time mean3.24.35.52.1-2.32.0-1.22.22.02.22.1-2.4
Reaction time mean AUC2.93.85.21.9-2.21.9-1.02.11.82.02.1-2.3
Median of all reaction times2.63.54.91.9-2.01.8-1.02.01.92.21.9-2.0
Reaction time omissions0.60.81.71.1-1.30.6-0.50.80.60.60.9-1.3
Reaction time false alarm rate1.21.73.1-1.30.8-1.50.0-1.8-1.7-0.9-1.31.3
Reaction time premature initiation rate0.30.41.1-0.50.3-0.9-1.1-0.3-0.9-0.4-0.30.0
Reaction time premature initiations0.71.02.0-1.10.7-1.3-1.4-0.6-1.2-1.0-0.70.3
Std. dev. reaction times2.53.45.21.9-2.31.9-0.91.81.71.71.9-2.2
Reaction time trials completed0.40.51.1-0.80.8-0.7-0.8-0.5-0.5-1.0-0.70.5
Reaction time trials AUC0.30.51.3-0.80.8-0.5-1.1-0.4-0.3-1.0-0.60.4
Social response proportion7.27.810.93.3-2.83.2-0.32.73.02.33.0-3.2
Social responses0.40.51.00.8-0.80.7-0.00.20.61.00.7-0.8
Social time1.52.03.31.6-1.81.10.71.01.01.81.5-1.7
Conditioned locomotion0.30.41.8-0.20.30.1-1.3-0.5-0.2-1.1-0.00.3
Cocaine response after cond. corrected2.12.33.3-1.61.8-1.3-0.9-1.8-1.5-1.6-1.41.7
Cocaine response after cond. not corrected3.13.44.8-1.92.2-1.6-0.7-2.0-1.8-2.1-1.72.2
Cocaine response before conditioning0.10.10.2-0.40.2-0.30.5-0.2-0.4-0.4-0.20.4
Saline control response0.81.17.10.2-0.30.9-2.70.20.70.50.9-0.6
Condit. Reinf. active minus inactive responses0.60.71.90.2-0.51.2-1.40.21.20.80.8-0.2
Condit. Reinf. active-inactive response ratio0.50.51.10.3-0.61.0-0.80.31.00.90.7-0.3
Condit. Reinf. active responses0.40.61.60.4-0.61.2-0.20.41.31.00.8-0.2
Condit. Reinf. inactive responses0.30.31.00.5-0.50.61.00.60.60.40.6-0.3
Condit. Reinf. lever presses1.82.54.11.1-1.91.6-0.81.31.72.01.6-1.7
Condit. Reinf. lever reinforcers received0.50.81.90.4-0.61.3-0.30.51.41.10.9-0.2
Pavlov. Cond. lever latency3.44.77.2-1.92.3-2.30.7-2.0-2.3-2.7-2.52.2
Pavlov. Cond. magazine entry latency1.72.05.50.9-1.70.9-2.30.81.01.11.3-1.7
Pavlov. Cond. change in total contacts3.75.27.62.1-2.32.7-0.42.12.72.82.5-2.0
Pavlov. Cond. index score3.54.66.61.9-2.52.1-1.21.92.22.62.4-2.3
Pavlov. Cond. latency score2.53.14.81.5-2.01.7-0.91.51.72.22.0-1.9
Pavlov. Cond. lever contacts2.94.06.51.7-2.22.1-0.51.92.12.62.3-2.0
Pavlov. Cond. magazine entry number2.43.04.1-1.32.0-1.61.8-1.4-1.6-1.8-1.92.0
Pavlov. Cond. intertrial magazine entries0.81.02.2-0.61.4-0.51.5-0.7-0.5-0.8-1.01.4
Pavlov. Cond. lever-magazine prob. diff.4.15.27.52.1-2.62.3-0.92.22.32.72.6-2.4
Pavlov. Cond. response bias3.14.36.01.6-2.52.1-1.51.82.12.42.3-2.2
Conditioned reinforcement - actives3.13.05.4-2.21.6-2.3-1.5-1.5-2.0-1.0-1.91.2
Conditioned reinforcement - inactives3.33.86.0-2.32.0-2.4-1.9-1.5-2.3-1.7-1.81.1
Conditioned locomotion2.63.24.9-2.11.8-2.20.5-2.1-2.0-0.9-1.91.7
Intermittent access intake day 1-15 change0.40.43.4-0.1-0.1-0.2-1.80.2-0.00.6-0.0-0.3
Intermittent access intake escalation0.40.42.9-0.0-0.0-0.2-1.70.10.00.6-0.1-0.2
Intermittent access intake escalation 21.11.13.00.9-0.50.8-1.71.30.91.00.6-1.1
Intermitt. access day 1 inactive lever presses0.30.30.90.3-0.30.4-0.40.80.3-0.20.7-0.9
Intermitt. access day 15 inactive lever presses1.21.37.90.1-0.90.1-2.81.30.10.10.7-1.1
Intermitt. access escalation Index1.00.91.80.6-1.30.6-1.10.90.20.81.2-1.1
Intermittent access day 1 total infusions0.10.10.2-0.1-0.4-0.2-0.10.1-0.10.30.4-0.4
Intermittent access day 15 total infusions0.30.42.4-0.4-0.3-0.5-1.6-0.0-0.30.60.2-0.3
Intermittent access terminal intake (last 3 days)0.30.41.80.0-0.5-0.1-1.30.40.10.80.5-0.5
Intermittent access total infusions0.20.21.2-0.2-0.4-0.3-1.10.1-0.20.50.4-0.4
Intermittent access day 1 locomotion0.20.21.3-0.50.0-0.51.1-0.3-0.40.40.10.1
Intermittent access day 15 total locomotion0.40.41.2-1.00.2-1.1-0.2-0.4-1.0-0.1-0.10.1
Intermittent access total locomotion0.80.92.0-1.30.7-1.40.7-0.9-1.20.0-0.70.9
Intermittent access standard deviation0.30.31.4-0.30.5-0.5-1.2-0.4-0.2-0.2-0.6-0.0
Cocaine induced anxiety0.40.41.1-0.40.5-0.5-1.1-0.6-0.3-0.1-1.00.5
Post-drug Anxiety1.41.62.60.9-1.60.9-1.61.21.11.41.0-1.3
Baseline Anxiety4.54.78.02.0-2.52.0-0.82.51.91.32.8-2.7
Lifetime Intake0.30.31.0-0.70.1-0.9-1.0-0.5-0.70.1-0.20.1
Incentive Sensitization - Responses0.30.30.9-0.60.9-0.5-0.6-0.2-0.5-0.2-0.50.4
Incentive Sensitization - Breakpoint0.30.30.9-0.61.0-0.6-0.7-0.3-0.5-0.2-0.50.5
Progressive ratio test 1 active lever presses0.20.20.7-0.7-0.1-0.8-0.1-0.4-0.60.4-0.20.2
Progressive ratio test 1 breakpoint0.10.20.4-0.5-0.2-0.70.0-0.2-0.40.7-0.00.0
Progressive ratio test 1 inactive lever presses0.60.62.3-0.90.1-1.0-1.5-0.3-0.9-0.2-0.5-0.1
Progressive ratio test 2 active lever presses0.20.20.3-0.50.5-0.6-0.4-0.2-0.40.4-0.30.2
Progressive ratio test 2 breakpoint0.10.10.3-0.30.2-0.4-0.3-0.0-0.20.5-0.10.0
Progressive ratio test 2 inactive lever presses0.60.74.3-0.4-0.4-0.5-2.10.4-0.20.60.1-0.8
Total sessions with >9 infusions0.60.71.6-1.20.2-1.3-0.1-1.0-1.10.5-0.50.8
Short access day 1 total inactive lever presses1.21.34.7-1.10.1-1.2-2.2-0.6-1.2-1.4-0.50.2
Short access day 10 total inactive lever presses1.92.13.71.5-1.41.6-1.11.71.50.41.5-1.9
Short access day 1 total infusions2.22.34.1-1.90.9-2.0-1.0-1.7-1.9-1.2-1.41.3
Short access day 10 total infusions0.50.51.3-1.10.1-1.2-0.5-0.9-0.90.3-0.40.5
Short access total infusions0.40.51.2-1.00.2-1.1-0.4-0.7-0.90.1-0.40.4
Short access day 1 locomotion1.01.12.0-1.40.4-1.40.0-1.3-1.20.3-0.91.1
Short access day 10 total locomotion1.01.12.3-1.50.7-1.50.4-1.3-1.10.0-1.10.9
Short access total locomotion1.51.52.6-1.51.1-1.61.3-1.4-1.20.5-1.21.2
Compulsive drug intake1.21.24.2-1.00.9-0.9-0.2-1.0-1.1-2.0-1.20.8
One hour access (0.3 mA shock)1.51.83.0-1.51.5-1.5-0.4-1.5-1.4-0.9-1.71.2
One hour access (shock baseline)0.10.10.90.0-0.1-0.1-0.20.00.10.90.2-0.2
Number of responses in last shaping day1.91.92.6-1.51.2-1.5-1.3-1.6-1.6-1.0-1.51.1
Context. condit. distance diff. score0.10.10.3-0.50.3-0.5-0.1-0.5-0.50.0-0.30.4
Locomotion velocity, session 11.71.82.7-1.60.6-1.6-1.2-1.6-1.4-1.1-1.50.9
Locomotion distance, session 14.96.38.5-2.82.2-2.9-0.2-2.9-2.8-2.3-2.92.5
Locomotion velocity, session 22.32.74.0-1.91.4-1.90.6-2.0-1.7-1.1-1.91.5
Locomotion distance, session 25.68.011.4-3.12.8-2.8-0.9-3.4-2.7-2.6-3.33.0
Locomotion velocity, session 33.94.56.3-2.42.0-2.40.3-2.3-2.3-2.0-2.52.1
Locomotion distance, session 31.31.42.3-1.10.9-1.30.6-1.3-1.3-1.2-1.51.4
Stereotopy head waving bouts, day 30.10.10.4-0.10.10.3-0.70.20.0-0.30.4-0.2
Stereotopy head waving duration, day 30.10.10.40.0-0.00.3-0.60.20.10.10.5-0.3
Locomotion velocity, session 71.71.82.8-1.61.3-1.3-1.1-1.7-1.4-1.3-1.21.3
Locomotion distance, session 70.91.22.8-1.10.7-0.9-1.7-1.4-1.0-0.7-0.80.9
Stereotopy head waving bouts, day 70.40.50.90.6-0.51.0-0.20.70.90.40.7-0.7
Stereotopy head waving duration, day 70.00.10.30.00.10.20.60.10.0-0.30.1-0.1
Locomotion velocity, session 81.51.82.8-1.71.2-1.6-1.0-1.5-1.5-1.1-1.51.0
Locomotion distance, session 84.36.49.2-2.92.5-2.8-0.9-3.0-2.6-1.8-2.92.6
Degree of sensitization distance0.70.73.80.2-0.50.6-1.90.20.40.50.9-0.8
Degree of sensitization stereotypy0.60.70.90.8-0.81.00.30.81.00.80.8-1.0
Condit. Reinf. active minus inactive responses0.10.10.30.40.10.50.40.30.4-0.40.20.3
Condit. Reinf. active-inactive response ratio0.10.10.30.40.00.60.50.30.4-0.30.20.3
Condit. Reinf. active responses0.00.10.20.20.20.20.30.00.1-0.4-0.00.3
Condit. Reinf. inactive responses0.10.10.7-0.2-0.1-0.1-0.8-0.1-0.00.0-0.0-0.2
Incentive salience index mean0.30.41.8-0.10.6-0.11.3-0.2-0.2-0.6-0.40.8
Condit. Reinf. lever presses0.40.64.60.10.2-0.12.20.1-0.00.3-0.30.5
Time in familiar zone, hab. session 10.30.31.50.1-0.5-0.11.20.4-0.10.40.4-0.4
Time in novel zone, hab. session 10.30.31.10.2-0.20.6-1.10.20.60.30.3-0.3
Total zone transitions, hab. session 11.01.52.2-1.30.9-1.5-0.3-1.4-1.5-1.2-1.31.0
Total locomotion distance, hab. session 11.42.12.8-1.51.2-1.7-0.2-1.6-1.6-1.5-1.61.4
Locomotion velocity, hab. session 12.13.03.8-1.71.6-1.90.1-2.0-1.9-1.8-2.01.9
Time in familiar zone, hab. session 20.60.61.1-0.91.1-0.9-0.2-0.7-0.7-0.7-0.90.8
Time in novel zone, hab. session 21.51.52.31.2-1.51.4-0.61.11.21.01.3-1.3
Total zone transitions, hab. session 20.30.41.2-0.80.3-0.4-1.1-0.7-0.5-0.3-0.40.4
Total locomotion distance, hab. session 21.31.72.6-1.51.0-1.3-1.5-1.6-1.2-1.2-1.41.2
Locomotion velocity, hab. session 22.12.84.2-2.01.4-1.8-1.2-2.0-1.7-1.5-1.81.6
Novel to familiar place preference ratio0.10.10.4-0.1-0.60.30.00.10.20.30.0-0.0
Novelty place preference0.10.10.5-0.0-0.70.30.40.20.20.30.1-0.1
Time in novel zone, NPP test0.30.31.00.3-1.00.70.10.50.60.60.5-0.4
Total zone transitions, NPP test1.01.42.2-1.31.0-1.3-0.3-1.5-1.2-0.9-1.41.4
Total locomotion distance, NPP test2.63.65.2-2.11.5-2.0-1.2-2.3-1.9-1.6-2.12.0
Locomotion velocity, NPP test3.34.76.7-2.41.8-2.3-1.0-2.6-2.2-1.9-2.42.4
Pavlov. Cond. lever latency1.11.57.30.5-0.61.1-2.70.51.00.61.1-0.9
Pavlov. Cond. magazine entry latency1.21.53.81.4-1.21.12.01.41.20.60.8-0.8
Pavlov. Cond. change in total contacts1.31.410.20.00.7-0.33.20.1-0.3-0.5-0.70.9
Pavlov. Cond. index score0.91.19.20.5-0.00.13.00.50.10.1-0.20.2
Pavlov. Cond. latency score1.01.39.7-0.10.5-0.53.1-0.0-0.5-0.4-0.70.8
Pavlov. Cond. lever contacts0.60.75.40.00.2-0.42.3-0.0-0.30.0-0.40.4
Pavlov. Cond. magazine entry number1.72.23.9-1.61.3-1.5-2.0-1.7-1.6-1.0-1.21.0
Pavlov. Cond. intertrial magazine entries2.63.17.0-1.51.9-1.2-2.7-1.8-1.4-1.9-1.51.5
Pavlov. Cond. lever-magazine prob. diff.1.01.310.40.7-0.10.23.20.70.30.3-0.10.1
Pavlov. Cond. response bias1.11.45.71.2-0.81.02.41.21.00.70.7-0.5
Bone: apparent density0.20.30.8-0.70.2-0.70.3-0.5-0.9-0.5-0.10.1
Bone surface0.10.20.7-0.0-0.70.0-0.70.1-0.10.20.7-0.8
Bone volume0.10.20.5-0.4-0.3-0.2-0.7-0.2-0.4-0.20.5-0.4
Bone: connectivity density0.50.82.1-1.00.7-1.30.3-1.0-1.5-0.9-0.60.5
Bone: cortical apparent density0.30.42.90.00.5-0.11.7-0.0-0.1-0.0-0.30.7
Bone: cortical area0.40.61.40.7-0.51.00.31.10.70.71.2-0.7
Bone: cortical porosity0.60.71.11.1-1.00.80.51.00.70.60.6-0.6
Bone: cortical porosity1.01.11.61.3-1.21.20.41.21.00.90.9-0.9
Bone: cortical thickness0.50.93.70.9-0.30.91.91.00.50.60.9-0.2
Bone: cortical thickness0.40.51.7-0.30.1-1.01.3-0.2-1.0-0.6-0.50.2
Bone: cortical tissue density0.20.32.20.00.4-0.11.5-0.1-0.1-0.0-0.30.6
Bone: elastic displacement0.20.20.50.5-0.60.40.40.50.40.70.4-0.5
Bone: elastic work3.14.05.22.2-2.12.10.72.22.02.32.1-1.9
Bone: endosteal estimation2.14.56.61.6-2.31.9-2.51.82.01.72.4-2.6
Bone: endosteal perimeter0.51.05.80.3-0.30.9-2.40.40.80.40.9-0.8
Bone: final force0.91.52.21.2-1.21.50.31.31.41.21.5-1.1
Bone: final moment0.81.31.91.1-1.21.30.11.31.21.01.4-1.1
Bone: marrow area2.04.46.81.5-2.31.9-2.61.82.01.72.3-2.5
Bone: maximum diameter0.61.22.80.5-1.10.8-1.70.80.70.91.2-1.4
Bone: maximum force0.71.32.31.1-1.11.50.21.31.31.01.4-0.8
Bone: maximum moment0.71.22.01.1-1.11.40.21.31.20.91.4-0.9
Bone: minimum diameter0.61.11.80.7-0.81.2-0.71.11.21.01.3-0.9
Bone: periosteal estimation1.53.04.41.4-1.71.8-1.61.71.71.42.1-2.0
Bone: periosteal perimeter0.20.41.90.0-0.10.8-1.40.20.60.30.7-0.4
Bone: post-yield work0.30.41.20.5-0.11.1-0.30.60.8-0.20.7-0.2
Bone: stiffness0.20.30.80.3-0.60.9-0.20.50.80.40.8-0.3
Bone: tissue strength0.90.91.80.8-0.81.40.40.71.21.21.0-0.5
Bone: trabecular number0.40.61.3-0.90.5-0.90.6-0.8-1.2-0.9-0.40.5
Bone: trabecular spacing1.72.23.51.6-1.31.6-0.11.51.81.91.4-1.3
Bone: trabecular thickness0.10.10.5-0.0-0.1-0.50.40.2-0.7-0.50.1-0.3
Bone: trabecular tissue density0.60.82.00.9-0.60.91.40.90.81.00.6-0.1
Breakpoint value in progressive ratio session0.40.50.70.5-0.80.6-0.60.60.70.60.7-0.8
Distance traveled before self-admin0.60.61.00.9-0.60.80.20.81.00.90.7-0.9
Distance traveled after self-admin0.50.63.40.10.8-0.01.8-0.6-0.2-0.0-0.50.6
Delta time in closed arm before/after self-admin0.80.81.6-1.10.4-1.3-0.4-0.7-1.2-1.0-0.70.7
Delta time in open arm before/after self-admin1.61.52.01.3-1.21.4-0.11.31.41.21.4-1.3
Diff in mean of infusions in LGA sessions0.10.10.7-0.00.4-0.00.9-0.10.3-0.1-0.30.1
Extinction: sum of active levers before priming0.20.20.80.1-0.70.0-0.90.30.1-0.30.2-0.4
Active lever presses in extinction session 60.90.93.60.3-0.90.2-1.90.90.30.60.8-1.2
Delta distance traveled before/after self-admin1.21.25.5-0.31.2-0.42.3-0.9-0.7-0.2-0.81.3
Delta ambulatory time before/after self-admin0.91.03.4-0.51.0-0.61.9-0.9-0.7-0.3-0.81.2
Time in closed arm before self-admin0.20.21.3-0.20.0-0.1-1.1-0.3-0.1-0.30.10.0
Time in closed arm after self-admin2.72.84.7-2.21.1-2.1-1.5-1.6-2.0-1.6-1.21.4
Time in open arm before self-admin0.30.31.90.60.30.31.40.40.20.20.0-0.1
Time in open arm after self-admin1.92.13.71.9-0.81.81.41.41.71.51.2-1.2
Sum of active levers in priming session hrs 5-60.90.91.8-1.10.5-1.1-0.9-0.9-1.1-1.3-0.90.6
Time to tail flick, vehicle, before self-admin4.24.27.71.5-2.11.6-2.82.61.60.42.3-2.5
Time to tail flick, vehicle, after self-admin0.10.10.20.4-0.30.3-0.30.40.4-0.10.1-0.3
Time to tail flick, test, before self-admin0.10.10.5-0.20.6-0.1-0.4-0.1-0.1-0.7-0.30.3
Time to tail flick, test, after self-admin1.31.36.4-1.30.2-1.2-2.5-0.0-1.1-1.0-0.50.1
Delta time to tail flick, vehicle, before/after SA1.51.52.5-1.11.2-1.10.9-1.5-1.1-0.7-1.61.5
Delta time to tail flick, test, before/after SA0.40.41.8-0.7-0.0-0.8-1.3-0.1-0.6-0.1-0.3-0.0
Ambulatory time before self-admin0.50.50.80.8-0.60.7-0.10.70.80.90.6-0.8
Ambulatory time after self-admin0.70.83.8-0.30.9-0.42.0-0.7-0.40.0-0.70.9
Total heroin consumption0.50.62.6-0.70.4-0.7-1.6-0.1-0.6-1.2-0.3-0.1
Area under the delay curve0.50.53.80.7-0.10.22.00.00.40.5-0.10.1
Delay disc. indifference point, 0s delay1.11.22.01.4-0.81.11.20.91.21.40.8-0.8
Delay disc. indifference point, 16s delay0.90.92.4-0.50.8-0.81.6-1.0-0.7-0.7-1.01.1
Delay disc. indifference point, 2s delay1.41.63.41.5-1.01.21.31.01.31.81.0-0.9
Delay disc. indifference point, 24s delay1.71.72.8-0.71.3-1.11.7-1.3-1.0-1.4-1.41.5
Delay disc. indifference point, 4s delay1.41.52.61.4-1.31.10.91.11.21.61.0-1.1
Delay disc. indifference point, 8s delay0.50.52.70.00.5-0.21.6-0.5-0.1-0.2-0.80.8
Delay discount exponential model param0.40.53.6-0.5-0.0-0.0-1.90.2-0.2-0.30.2-0.3
Delay discount hyperbolic model param0.50.53.2-0.70.2-0.3-1.8-0.1-0.5-0.7-0.0-0.0
Fecal boli incidents, locomotor time 10.50.61.4-0.80.3-0.7-1.2-1.0-0.6-0.7-0.80.2
Change in fecal boli incidents, locomotor task0.20.10.4-0.50.2-0.30.20.0-0.4-0.60.10.6
Time >=10cm from walls, locomotor time 10.10.10.5-0.20.5-0.20.0-0.2-0.2-0.7-0.30.5
Bouts of movement, locomotor time 10.91.01.6-0.91.0-1.2-0.3-1.3-1.0-1.0-1.10.6
Total resting periods, locomotor time 11.41.52.3-1.21.2-1.4-0.6-1.5-1.3-1.4-1.30.8
Rest time, locomotor task time 10.40.50.8-0.60.6-0.7-0.8-0.9-0.5-0.9-0.70.5
Distance moved, locomotor task time 10.80.94.3-0.41.1-0.22.1-0.4-0.5-0.2-0.71.1
Vertical activity count, locomotor time 10.40.50.90.6-0.50.61.00.80.40.90.6-0.4
Time >=10cm from walls, locomotor time 21.92.13.41.5-1.71.6-0.61.61.31.11.8-1.4
Bouts of movement, locomotor time 20.20.31.00.5-0.00.50.40.20.61.00.4-0.4
Total resting periods, locomotor time 20.30.31.00.5-0.10.50.10.40.71.00.4-0.6
Rest time, locomotor task time 20.10.10.50.1-0.3-0.1-0.70.10.30.2-0.1-0.5
Distance moved, locomotor task time 20.91.12.0-0.61.4-0.51.2-1.0-0.8-1.0-1.01.4
Vertical activity count, locomotor time 20.30.31.60.10.40.31.3-0.50.1-0.1-0.10.6
Weight adjusted by age0.60.70.90.9-0.80.9-0.91.00.80.21.0-0.9
Seeking ratio, delayed vs. immediate footshock0.50.51.90.5-1.40.5-0.50.70.40.50.8-0.8
Locomotion in novel chamber0.81.02.4-1.20.5-1.2-1.1-0.6-1.3-1.6-0.50.6
Locomotion in novel chamber post-restriction2.22.64.1-1.81.2-1.90.4-1.7-2.0-1.8-1.41.5
Progressive ratio2.63.04.3-2.01.3-2.1-0.4-1.9-2.0-1.9-1.71.6
Food seeking constrained by brief footshock3.84.67.4-1.82.4-2.01.9-2.7-2.0-1.2-2.42.6
Seeking ratio, punishment vs. effort0.91.12.61.2-0.21.11.50.61.11.60.6-0.4
Run reversals in cocaine runway, females1.11.11.90.9-1.20.80.01.11.01.41.3-1.2
Run reversals in cocaine runway, males1.81.74.31.3-0.91.61.10.91.62.11.0-0.7
Latency to leave start box in cocaine runway0.20.21.0-0.1-0.4-0.0-1.00.2-0.3-0.90.2-0.1
Latency to leave start box in cocaine runway, F0.60.72.50.4-1.00.4-1.61.00.2-0.10.9-0.8
Latency to leave start box in cocaine runway, M1.00.91.4-0.81.0-0.80.7-1.0-0.8-1.1-1.11.2
Cd content in liver0.50.51.00.6-1.00.50.80.70.40.61.0-0.7
Co content in liver1.11.32.6-1.11.0-1.41.0-1.0-1.6-0.9-0.91.0
Cu content in liver0.30.40.6-0.70.4-0.6-0.4-0.7-0.6-0.8-0.60.6
Fe content in liver0.70.82.31.0-0.51.50.20.91.30.60.9-0.1
K content in liver1.41.45.2-0.61.1-1.02.3-0.6-0.8-0.3-1.41.2
Mg content in liver0.50.53.10.20.7-0.01.70.10.00.2-0.50.7
Mn content in liver2.32.73.7-1.81.9-1.5-0.8-1.8-1.5-1.8-1.61.7
Na content in liver0.70.75.60.1-0.0-0.32.40.1-0.20.6-0.40.4
Rb content in liver0.70.82.41.2-0.30.91.61.00.90.60.6-0.4
Se content in liver0.50.61.31.1-0.70.70.91.10.50.30.6-0.5
Sr content in liver1.11.01.9-1.40.6-1.1-0.4-1.2-1.1-0.8-0.90.9
Zn content in liver0.30.31.0-0.30.5-0.51.0-0.2-0.7-0.3-0.40.6