| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | alternative polyA | ENSRNOT00000107856 | 0.0190 | 0.0143 | 8.0e-03 | 0.008 | 0.017 | 0.005 | 0.007 | 3.6e-02 | 4.9e-03 | 8.2e-02 | 5.1e-02 |
| 2 | Adipose | alternative polyA | ENSRNOT00000111876 | 0.0187 | 0.0142 | 9.1e-03 | 0.008 | 0.016 | 0.002 | 0.007 | 3.8e-02 | 5.7e-03 | 2.0e-01 | 4.5e-02 |
| 3 | Adipose | gene expression | ENSRNOG00000062661 | 0.0390 | 0.0240 | 2.8e-05 | 0.042 | 0.031 | 0.028 | 0.025 | 1.9e-05 | 1.8e-04 | 3.6e-04 | 7.7e-04 |
| 4 | BLA | gene expression | ENSRNOG00000062661 | 0.0794 | 0.0493 | 2.9e-03 | 0.029 | 0.030 | 0.041 | 0.041 | 1.0e-02 | 9.2e-03 | 2.8e-03 | 3.0e-03 |
| 5 | Brain | gene expression | ENSRNOG00000062661 | 0.0960 | 0.0430 | 8.7e-09 | 0.084 | 0.077 | 0.072 | 0.076 | 3.6e-08 | 1.3e-07 | 3.5e-07 | 1.4e-07 |
| 6 | LHb | gene expression | ENSRNOG00000062661 | 0.3741 | 0.1382 | 4.8e-05 | 0.156 | 0.159 | 0.153 | 0.152 | 1.6e-04 | 1.4e-04 | 1.8e-04 | 1.9e-04 |
| 7 | PL | gene expression | ENSRNOG00000062661 | 0.1136 | 0.0570 | 1.8e-06 | 0.051 | 0.067 | 0.051 | 0.057 | 9.9e-05 | 8.3e-06 | 9.0e-05 | 4.0e-05 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
|---|---|---|---|---|---|---|---|---|---|---|
| Tibia length | 10.4 | 29.4 | 47.8 | -6.9 | 6.9 | 6.2 | -3.5 | -5.2 | -4.5 | -3.7 |
| Bone: elastic work | 8.7 | 11.3 | 13.5 | -3.4 | 3.4 | 2.7 | -3.3 | -3.6 | -3.7 | -3.4 |
| Bone: maximum moment | 7.6 | 13.2 | 25.7 | -5.0 | 5.1 | 5.0 | -1.4 | -2.7 | -2.2 | -1.4 |
| Bone: cortical area | 7.0 | 10.6 | 21.5 | -4.6 | 4.6 | 4.0 | -1.6 | -2.3 | -2.2 | -1.6 |
| Bone: final moment | 6.6 | 10.9 | 20.9 | -4.5 | 4.6 | 4.2 | -1.5 | -2.8 | -2.2 | -1.6 |
| Bone: maximum force | 6.5 | 11.3 | 23.1 | -4.8 | 4.8 | 4.7 | -1.0 | -2.3 | -1.7 | -1.0 |
| Bone: cortical thickness | 6.3 | 10.4 | 16.2 | -4.0 | 4.0 | 3.0 | -2.5 | -2.8 | -3.2 | -2.8 |
| Bone: final force | 5.6 | 9.1 | 18.5 | -4.3 | 4.3 | 4.0 | -1.1 | -2.4 | -1.8 | -1.2 |
| Bone: periosteal perimeter | 4.3 | 7.0 | 11.2 | -3.3 | 3.3 | 3.1 | -1.9 | -2.3 | -2.3 | -1.8 |
| Condit. Reinf. active-inactive response ratio | 4.1 | 4.2 | 6.9 | -2.6 | 2.6 | 2.3 | -1.5 | -1.4 | -2.0 | -1.6 |
| Baseline Anxiety | 3.8 | 4.0 | 7.0 | 1.7 | -1.7 | -1.7 | 2.2 | 2.7 | 2.0 | 1.9 |
| Delay disc. indifference point, 16s delay | 3.7 | 3.8 | 5.5 | 1.5 | -1.6 | -1.3 | 2.2 | 2.4 | 2.3 | 2.1 |
| Locomotion distance, session 7 | 3.5 | 4.4 | 5.3 | 2.3 | -2.3 | -2.3 | 1.8 | 2.2 | 2.0 | 1.8 |
| Novelty place preference | 3.4 | 3.5 | 4.9 | -1.7 | 1.7 | 1.3 | -2.0 | -1.9 | -2.2 | -2.1 |
| Cocaine induced anxiety | 3.3 | 3.8 | 7.1 | -0.6 | 0.6 | 0.2 | -2.6 | -2.7 | -2.5 | -2.4 |
| Weight adjusted by age | 3.3 | 3.7 | 5.3 | -2.3 | 2.3 | 2.1 | -1.5 | -1.9 | -1.8 | -1.5 |
| Locomotion distance, session 3 | 3.2 | 3.4 | 6.4 | 2.4 | -2.4 | -2.5 | 1.2 | 1.8 | 1.1 | 0.9 |
| Novel to familiar place preference ratio | 3.1 | 3.2 | 4.4 | -1.6 | 1.6 | 1.3 | -1.9 | -1.9 | -2.1 | -2.0 |
| BMI without tail | 3.0 | 6.3 | 14.8 | -3.5 | 3.4 | 3.8 | 1.5 | -0.7 | 1.0 | 1.4 |
| Bone: minimum diameter | 2.9 | 5.4 | 10.4 | -3.2 | 3.2 | 2.6 | -1.5 | -1.7 | -1.9 | -1.5 |
| Bone: periosteal estimation | 2.8 | 5.8 | 13.7 | -3.6 | 3.6 | 3.7 | -0.1 | -1.0 | -0.7 | -0.1 |
| Body weight | 2.7 | 11.5 | 26.6 | -4.8 | 4.9 | 5.2 | -0.4 | -2.1 | -1.2 | -0.5 |
| Pavlov. Cond. magazine entry number | 2.7 | 3.3 | 5.9 | -1.5 | 1.5 | 0.6 | -2.2 | -1.5 | -2.4 | -2.3 |
| Locomotion velocity, session 2 | 2.7 | 3.1 | 5.6 | 2.4 | -2.4 | -2.0 | 1.1 | 1.7 | 1.3 | 1.1 |
| Time in novel zone, NPP test | 2.7 | 2.9 | 4.0 | -1.5 | 1.5 | 1.2 | -1.8 | -1.8 | -2.0 | -1.9 |
| Bone: cortical tissue density | 2.7 | 3.5 | 8.1 | 2.8 | -2.8 | -2.8 | 0.2 | 1.0 | 0.4 | 0.0 |
| Delay disc. indifference point, 24s delay | 2.7 | 2.6 | 5.4 | 2.3 | -2.3 | -1.9 | 1.1 | 0.9 | 1.0 | 0.8 |
| Pavlov. Cond. magazine entry latency | 2.6 | 3.0 | 5.2 | 1.5 | -1.5 | -0.6 | 2.1 | 1.4 | 2.3 | 2.2 |
| Bone: trabecular thickness | 2.6 | 3.2 | 6.5 | -0.5 | 0.5 | 0.5 | -2.6 | -1.6 | -2.5 | -2.5 |
| Pavlov. Cond. magazine entry number | 2.5 | 3.2 | 7.8 | 0.7 | -0.7 | -0.8 | 2.2 | 2.8 | 2.0 | 2.0 |
| Bone: cortical thickness | 2.5 | 3.0 | 3.7 | -1.9 | 1.9 | 1.6 | -1.6 | -1.5 | -1.9 | -1.7 |
| Conditioned locomotion | 2.4 | 2.9 | 7.5 | -2.7 | 2.7 | 2.2 | -0.2 | -0.6 | -0.4 | -0.2 |
| Pavlov. Cond. index score | 2.4 | 3.1 | 5.2 | -1.4 | 1.4 | 1.2 | -2.0 | -2.3 | -1.9 | -1.8 |
| Pavlov. Cond. lever-magazine prob. diff. | 2.4 | 3.0 | 5.3 | -1.3 | 1.3 | 1.0 | -2.0 | -2.3 | -1.9 | -1.9 |
| Retroperitoneal fat weight | 2.3 | 7.6 | 18.8 | -4.0 | 3.9 | 4.3 | 0.3 | -1.8 | -0.0 | 0.4 |
| Pavlov. Cond. latency score | 2.3 | 2.9 | 5.2 | -1.1 | 1.1 | 1.1 | -2.0 | -2.3 | -1.9 | -1.9 |
| Bone: cortical apparent density | 2.3 | 3.0 | 7.0 | 2.5 | -2.5 | -2.7 | 0.3 | 1.0 | 0.4 | 0.0 |
| Delay discount exponential model param | 2.3 | 2.5 | 4.4 | -2.0 | 2.0 | 2.1 | -1.0 | -1.3 | -1.1 | -0.9 |
| Delay discount hyperbolic model param | 2.2 | 2.4 | 4.5 | -2.0 | 2.0 | 2.1 | -0.9 | -1.3 | -1.1 | -0.9 |
| Tail length | 2.1 | 6.3 | 13.3 | -3.6 | 3.6 | 3.7 | 1.3 | -0.9 | 0.9 | 1.2 |
| Intermittent access standard deviation | 2.1 | 2.2 | 4.8 | 2.2 | -2.2 | -2.2 | 0.4 | -0.0 | 0.8 | 0.6 |
| Locomotion distance, session 8 | 2.1 | 3.2 | 6.0 | -1.2 | 1.1 | 0.9 | 2.4 | 2.1 | 2.0 | 2.2 |
| Condit. Reinf. active responses | 2.1 | 2.5 | 5.1 | -2.3 | 2.3 | 2.1 | -0.4 | -1.4 | -0.7 | -0.6 |
| Bone: cortical porosity | 2.1 | 2.2 | 6.2 | -0.9 | 1.0 | 1.9 | -1.3 | -2.5 | -1.2 | -1.0 |
| Bone: trabecular spacing | 2.1 | 2.7 | 6.1 | -0.6 | 0.6 | 0.7 | 2.5 | 1.4 | 2.1 | 2.2 |
| Delta ambulatory time before/after self-admin | 2.1 | 2.3 | 5.6 | 1.4 | -1.5 | -0.6 | 1.2 | 2.4 | 1.5 | 1.3 |
| Condit. Reinf. active minus inactive responses | 2.0 | 2.5 | 5.5 | -2.3 | 2.3 | 1.8 | -0.8 | -0.6 | -1.2 | -0.9 |
| Pavlov. Cond. magazine entry latency | 2.0 | 2.6 | 5.0 | -0.8 | 0.8 | 0.6 | -2.1 | -2.2 | -1.9 | -1.9 |
| Pavlov. Cond. response bias | 2.0 | 2.4 | 5.1 | -0.6 | 0.7 | 0.7 | -2.0 | -2.3 | -1.8 | -1.8 |
| Heart weight | 1.9 | 2.8 | 6.7 | -2.2 | 2.2 | 2.6 | -0.8 | -1.4 | -0.7 | -0.4 |
| Bone: cortical porosity | 1.9 | 2.1 | 5.9 | -0.6 | 0.7 | 1.7 | -1.4 | -2.4 | -1.3 | -1.1 |
| Time to tail flick, test, after self-admin | 1.9 | 1.9 | 3.5 | 1.9 | -1.9 | -1.9 | 0.8 | 1.1 | 0.9 | 0.6 |
| Change in fecal boli incidents, locomotor task | 1.9 | 1.8 | 4.9 | 2.2 | -2.2 | -1.2 | -0.9 | 0.4 | -0.3 | -0.5 |
| Bone: maximum diameter | 1.8 | 3.4 | 7.7 | -2.8 | 2.8 | 2.5 | -0.5 | -1.0 | -0.8 | -0.4 |
| Bone: stiffness | 1.8 | 2.8 | 8.4 | -2.3 | 2.3 | 2.9 | 0.4 | -0.6 | 0.0 | 0.5 |
| Bone: tissue strength | 1.8 | 1.7 | 3.9 | -2.0 | 2.0 | 1.8 | 0.8 | -0.4 | 0.3 | 0.6 |
| Area under the delay curve | 1.8 | 1.9 | 2.9 | 1.7 | -1.7 | -1.7 | 1.0 | 1.4 | 1.1 | 1.0 |
| Locomotion velocity, session 3 | 1.7 | 2.0 | 5.5 | 2.0 | -2.0 | -2.3 | 0.4 | 0.5 | 0.4 | 0.2 |
| Total locomotion distance, NPP test | 1.7 | 2.3 | 4.1 | -0.8 | 0.7 | 0.9 | 2.0 | 1.7 | 1.9 | 2.0 |
| Pavlov. Cond. lever latency | 1.7 | 2.2 | 4.2 | 0.4 | -0.4 | -0.4 | 2.0 | 1.9 | 1.9 | 1.9 |
| Times rat made contact with spout | 1.6 | 1.9 | 4.3 | -0.6 | 0.6 | 0.5 | -1.8 | -2.1 | -1.5 | -1.6 |
| Delta distance traveled before/after self-admin | 1.6 | 1.7 | 3.9 | 1.1 | -1.2 | -0.5 | 1.2 | 2.0 | 1.5 | 1.3 |
| Latency to leave start box in cocaine runway, F | 1.6 | 1.7 | 3.2 | -0.6 | 0.6 | 1.4 | 1.8 | 0.7 | 1.6 | 1.7 |
| Mean time between licks in bursts | 1.5 | 2.1 | 3.6 | 1.9 | -1.9 | -1.7 | 0.8 | 1.6 | 0.9 | 0.7 |
| Std. dev. time between licks in bursts | 1.5 | 1.8 | 3.5 | -0.6 | 0.6 | 0.0 | 1.8 | 1.9 | 1.6 | 1.6 |
| Total zone transitions, NPP test | 1.5 | 2.2 | 4.5 | -0.1 | 0.1 | -0.1 | 2.0 | 2.1 | 1.8 | 1.9 |
| Time to tail flick, test, before self-admin | 1.5 | 1.5 | 2.4 | 1.1 | -1.1 | -1.1 | 1.5 | 0.5 | 1.6 | 1.3 |
| Locomotion in novel chamber post-restriction | 1.5 | 1.7 | 3.8 | -1.9 | 1.9 | 1.7 | -0.7 | -0.5 | -0.7 | -0.6 |
| Fe content in liver | 1.5 | 1.7 | 2.4 | 1.2 | -1.2 | -0.8 | 1.5 | 1.2 | 1.5 | 1.6 |
| Mg content in liver | 1.5 | 1.5 | 3.0 | 0.6 | -0.6 | -1.0 | 1.6 | 1.1 | 1.7 | 1.5 |
| Sr content in liver | 1.5 | 1.4 | 2.6 | 0.4 | -0.4 | -0.7 | -1.5 | -1.2 | -1.5 | -1.6 |
| Glucose | 1.4 | 2.1 | 4.4 | 2.1 | -2.1 | -0.9 | -1.2 | -1.3 | -1.0 | -1.0 |
| Reaction time trials on left | 1.4 | 1.9 | 3.8 | -0.5 | 0.5 | -0.2 | 2.0 | 1.8 | 1.7 | 1.8 |
| Reaction time trials completed | 1.4 | 1.9 | 3.8 | -0.5 | 0.5 | -0.2 | 2.0 | 1.8 | 1.7 | 1.8 |
| Locomotion velocity, session 1 | 1.4 | 1.5 | 2.4 | 1.6 | -1.5 | -1.3 | -1.2 | -0.4 | -1.1 | -1.2 |
| Condit. Reinf. active minus inactive responses | 1.4 | 1.6 | 3.3 | -1.8 | 1.8 | 1.4 | -0.4 | -1.1 | -0.8 | -0.7 |
| Length with tail | 1.3 | 4.8 | 11.4 | -3.1 | 3.1 | 3.4 | -0.4 | -1.2 | -0.8 | -0.3 |
| Reaction time number correct | 1.3 | 1.8 | 3.6 | -0.5 | 0.5 | -0.2 | 1.9 | 1.7 | 1.7 | 1.7 |
| Reaction time trials correct on left | 1.3 | 1.8 | 3.6 | -0.5 | 0.5 | -0.2 | 1.9 | 1.7 | 1.7 | 1.7 |
| Cocaine response before conditioning | 1.3 | 1.6 | 2.8 | 0.7 | -0.7 | -0.5 | 1.7 | 1.3 | 1.6 | 1.6 |
| Active lever presses in extinction session 6 | 1.3 | 1.3 | 3.1 | 1.8 | -1.7 | -1.1 | 0.6 | -0.5 | 0.6 | 0.6 |
| Liver weight, right | 1.2 | 2.0 | 5.8 | -1.9 | 1.9 | 2.4 | 0.0 | -1.0 | -0.1 | 0.3 |
| Reaction time trials AUC | 1.2 | 1.7 | 3.3 | -0.6 | 0.6 | -0.2 | 1.8 | 1.6 | 1.6 | 1.6 |
| Locomotion velocity, NPP test | 1.2 | 1.8 | 2.5 | -1.0 | 1.0 | 1.0 | 1.6 | 1.5 | 1.4 | 1.5 |
| Bone: elastic displacement | 1.2 | 1.3 | 2.9 | -1.2 | 1.2 | 0.6 | -0.9 | -1.7 | -1.1 | -1.1 |
| Ambulatory time before self-admin | 1.2 | 1.2 | 5.5 | -0.6 | 0.6 | -0.6 | -0.7 | -2.4 | -0.9 | -1.0 |
| Delay disc. indifference point, 4s delay | 1.2 | 1.2 | 5.5 | 1.0 | -1.0 | -2.3 | -0.2 | 0.9 | 0.0 | -0.3 |
| Light reinforcement 2 | 1.1 | 1.5 | 3.4 | -1.7 | 1.7 | 1.8 | -0.7 | -0.5 | -0.8 | -0.6 |
| Pavlov. Cond. intertrial magazine entries | 1.1 | 1.5 | 3.5 | -1.9 | 1.9 | 1.0 | -0.8 | -0.5 | -0.9 | -0.8 |
| Locomotion velocity, hab. session 2 | 1.1 | 1.5 | 3.3 | -1.8 | 1.8 | 1.6 | 0.8 | 0.7 | 0.5 | 0.7 |
| Time in open arm before self-admin | 1.1 | 1.2 | 1.8 | -1.1 | 1.1 | 0.7 | -1.3 | 0.7 | -1.4 | -1.2 |
| Cd content in liver | 1.1 | 1.2 | 1.8 | 1.3 | -1.3 | -1.0 | 0.9 | 1.3 | 0.9 | 0.8 |
| Left kidney weight | 1.0 | 2.8 | 7.9 | -2.0 | 2.0 | 2.8 | -1.0 | -0.7 | -1.3 | -0.8 |
| Intraocular pressure | 1.0 | 1.4 | 2.1 | -1.4 | 1.4 | 1.4 | 1.4 | 0.2 | 0.8 | 1.0 |
| Soleus weight | 1.0 | 2.8 | 5.4 | -2.3 | 2.3 | 1.8 | -1.3 | -1.0 | -1.4 | -1.3 |
| Social response proportion | 1.0 | 1.1 | 2.9 | 0.9 | -0.9 | -0.9 | 0.9 | 1.7 | 0.7 | 0.8 |
| Pavlov. Cond. lever-magazine prob. diff. | 1.0 | 1.3 | 3.0 | 0.4 | -0.4 | 0.3 | 1.6 | 0.7 | 1.7 | 1.7 |
| Short access day 10 total locomotion | 1.0 | 1.1 | 2.7 | 1.4 | -1.4 | -1.6 | -0.7 | -0.0 | -0.3 | -0.6 |
| Total locomotion distance, hab. session 2 | 1.0 | 1.3 | 2.4 | -1.6 | 1.5 | 1.4 | 0.8 | 0.9 | 0.6 | 0.8 |
| Bone: trabecular tissue density | 1.0 | 1.4 | 2.9 | 1.0 | -1.0 | -0.5 | 1.7 | 0.6 | 1.4 | 1.4 |
| Extinction: sum of active levers before priming | 1.0 | 1.1 | 1.8 | 1.3 | -1.3 | -1.0 | -1.0 | -0.8 | -0.7 | -0.8 |
| Run reversals in cocaine runway, males | 1.0 | 1.0 | 3.2 | -0.6 | 0.6 | 0.9 | -1.0 | -1.8 | -0.8 | -0.8 |
| Locomotor testing rearing | 0.9 | 1.4 | 2.1 | 1.4 | -1.5 | -1.2 | 1.0 | 0.7 | 1.3 | 1.1 |
| Pavlov. Cond. index score | 0.9 | 1.1 | 2.6 | 0.2 | -0.2 | 0.4 | 1.5 | 0.5 | 1.6 | 1.6 |
| Pavlov. Cond. latency score | 0.9 | 1.1 | 2.5 | 0.0 | -0.0 | 0.6 | 1.5 | 0.5 | 1.5 | 1.6 |
| Post-drug Anxiety | 0.9 | 0.9 | 1.6 | 0.6 | -0.6 | -0.9 | -1.2 | -0.8 | -1.2 | -1.3 |
| Short access day 1 total infusions | 0.9 | 1.0 | 2.4 | 1.5 | -1.5 | -1.3 | -0.3 | 0.8 | -0.1 | -0.2 |
| Locomotion distance, session 1 | 0.9 | 1.2 | 3.1 | 0.8 | -0.8 | -0.6 | 1.2 | 1.8 | 1.0 | 1.1 |
| Stereotopy head waving bouts, day 7 | 0.9 | 1.1 | 3.3 | -1.4 | 1.4 | 1.8 | 0.3 | -0.1 | -0.2 | 0.1 |
| Incentive salience index mean | 0.9 | 1.1 | 2.5 | -1.6 | 1.6 | 1.5 | 0.0 | -0.7 | -0.4 | -0.2 |
| Bone: endosteal estimation | 0.9 | 1.9 | 3.6 | -1.0 | 1.0 | 1.9 | 1.6 | 0.8 | 1.3 | 1.7 |
| Bone: marrow area | 0.9 | 1.9 | 3.5 | -0.9 | 0.9 | 1.9 | 1.6 | 0.8 | 1.3 | 1.7 |
| Distance traveled before self-admin | 0.9 | 0.9 | 4.8 | -0.2 | 0.2 | -0.7 | -0.4 | -2.2 | -0.6 | -0.7 |
| Latency to leave start box in cocaine runway | 0.9 | 1.0 | 1.9 | -0.1 | 0.1 | 1.2 | 1.4 | 0.4 | 1.3 | 1.4 |
| BMI with tail | 0.8 | 2.6 | 6.4 | -2.2 | 2.2 | 2.5 | -0.3 | -1.2 | -0.8 | -0.4 |
| Parametrial fat weight | 0.8 | 1.6 | 4.8 | -1.3 | 1.3 | 2.2 | -0.8 | -1.4 | -0.4 | -0.3 |
| Water consumed over 24 hours | 0.8 | 0.9 | 2.0 | 0.3 | -0.3 | -0.6 | -1.3 | -0.6 | -1.3 | -1.4 |
| Light reinforcement 1 | 0.8 | 1.4 | 2.1 | -1.4 | 1.4 | 1.4 | -1.3 | 0.1 | -1.1 | -1.0 |
| Pavlov. Cond. lever contacts | 0.8 | 1.1 | 2.3 | -1.5 | 1.4 | 1.5 | 0.7 | -0.2 | 0.5 | 0.7 |
| Locomotion distance, session 2 | 0.8 | 1.2 | 2.4 | 0.0 | -0.1 | -0.4 | 1.5 | 1.5 | 1.3 | 1.3 |
| Stereotopy head waving duration, day 7 | 0.8 | 1.0 | 2.3 | -1.4 | 1.5 | 1.5 | -0.1 | -0.1 | -0.6 | -0.4 |
| Degree of sensitization stereotypy | 0.8 | 0.9 | 2.5 | -1.3 | 1.3 | 1.6 | 0.3 | -0.2 | -0.2 | 0.1 |
| Pavlov. Cond. change in total contacts | 0.8 | 0.8 | 2.1 | 0.3 | -0.2 | 0.1 | -1.3 | -1.4 | -1.0 | -1.0 |
| Bone: endosteal perimeter | 0.8 | 1.7 | 3.6 | -1.9 | 1.9 | 1.9 | -0.3 | -0.8 | -0.5 | -0.1 |
| Delta time to tail flick, test, before/after SA | 0.8 | 0.7 | 1.9 | 0.5 | -0.5 | -0.1 | -1.4 | -0.1 | -1.1 | -1.1 |
| Time >=10cm from walls, locomotor time 2 | 0.8 | 0.8 | 1.8 | -1.3 | 1.4 | 0.2 | -0.6 | -0.2 | -1.0 | -0.9 |
| Delay discounting water rate 24 sec | 0.7 | 0.9 | 2.0 | -1.4 | 1.4 | 0.6 | 1.1 | 0.3 | 0.6 | 0.8 |
| Reaction time premature initiations | 0.7 | 1.1 | 2.6 | 0.7 | -0.7 | -0.5 | 1.2 | 1.6 | 1.1 | 1.0 |
| Condit. Reinf. lever reinforcers received | 0.7 | 0.9 | 2.3 | -1.5 | 1.5 | 1.4 | 0.1 | -0.0 | -0.2 | 0.1 |
| Pavlov. Cond. lever latency | 0.7 | 0.9 | 2.2 | 1.3 | -1.3 | -1.5 | -0.6 | 0.2 | -0.4 | -0.6 |
| Intermittent access intake escalation | 0.7 | 0.7 | 1.4 | 0.6 | -0.7 | -0.7 | 1.1 | 0.2 | 1.2 | 1.0 |
| Short access day 10 total inactive lever presses | 0.7 | 0.7 | 0.9 | -1.0 | 1.0 | 0.5 | -0.6 | -0.9 | -1.0 | -0.9 |
| Short access day 1 locomotion | 0.7 | 0.7 | 1.5 | 0.7 | -0.7 | -0.8 | -1.2 | -0.4 | -0.8 | -0.9 |
| Locomotion velocity, session 7 | 0.7 | 0.8 | 1.0 | 1.0 | -1.0 | -1.0 | 0.9 | 1.0 | 0.7 | 0.7 |
| Condit. Reinf. active-inactive response ratio | 0.7 | 0.8 | 1.8 | -1.3 | 1.3 | 0.5 | -0.2 | -0.6 | -0.9 | -0.7 |
| Time in closed arm after self-admin | 0.7 | 0.7 | 1.8 | 1.3 | -1.3 | -0.9 | -0.4 | 0.1 | -0.4 | -0.5 |
| Delay disc. indifference point, 8s delay | 0.7 | 0.8 | 1.8 | 1.3 | -1.2 | -1.3 | 0.1 | 0.7 | -0.1 | -0.2 |
| Total resting periods, locomotor time 2 | 0.7 | 0.7 | 3.5 | 0.4 | -0.4 | -0.0 | 0.7 | 1.9 | 0.5 | 0.6 |
| Seeking ratio, delayed vs. immediate footshock | 0.7 | 0.8 | 1.4 | -1.2 | 1.2 | 0.3 | -1.1 | -0.2 | -0.9 | -0.9 |
| Progressive ratio | 0.7 | 0.8 | 1.8 | 0.2 | -0.2 | 0.8 | 1.3 | 0.6 | 1.1 | 1.3 |
| Epididymis fat weight | 0.6 | 1.3 | 4.1 | -1.4 | 1.4 | 2.0 | 0.7 | -0.0 | 0.4 | 0.7 |
| Length without tail | 0.6 | 1.3 | 3.2 | -0.1 | 0.1 | 0.7 | -1.7 | -0.7 | -1.8 | -1.5 |
| Mean num. licks in bursts | 0.6 | 0.7 | 2.0 | -0.2 | 0.2 | 0.4 | -1.2 | -1.4 | -0.8 | -0.9 |
| Cocaine response after cond. not corrected | 0.6 | 0.7 | 1.6 | 1.2 | -1.2 | -1.3 | 0.0 | 0.7 | 0.2 | 0.1 |
| Saline control response | 0.6 | 0.8 | 1.8 | -1.3 | 1.3 | -0.1 | -0.4 | -1.0 | -0.6 | -0.7 |
| Condit. Reinf. active responses | 0.6 | 0.9 | 2.3 | -1.5 | 1.5 | 1.2 | -0.2 | -0.1 | -0.5 | -0.2 |
| Conditioned locomotion | 0.6 | 0.7 | 2.0 | 0.2 | -0.2 | -0.3 | 0.8 | 0.4 | 1.4 | 1.3 |
| Intermittent access intake escalation 2 | 0.6 | 0.6 | 3.2 | 0.5 | -0.5 | -0.4 | 0.1 | -1.8 | 0.4 | 0.3 |
| Intermitt. access escalation Index | 0.6 | 0.6 | 1.2 | -1.1 | 1.1 | 0.8 | -0.2 | 0.4 | -0.6 | -0.6 |
| Intermittent access day 1 total infusions | 0.6 | 0.7 | 1.5 | -1.2 | 1.2 | 1.2 | -0.0 | -0.0 | 0.1 | 0.2 |
| Short access day 1 total inactive lever presses | 0.6 | 0.7 | 2.1 | -0.4 | 0.4 | 1.0 | 0.7 | 1.5 | 0.7 | 0.8 |
| Short access total locomotion | 0.6 | 0.6 | 1.4 | 0.9 | -0.9 | -1.2 | -0.8 | 0.1 | -0.4 | -0.6 |
| Context. condit. distance diff. score | 0.6 | 0.8 | 0.9 | -0.9 | 0.9 | 0.9 | 0.9 | 0.9 | 0.8 | 0.9 |
| Pavlov. Cond. lever contacts | 0.6 | 0.7 | 1.3 | -0.4 | 0.4 | 0.5 | -1.1 | -1.1 | -0.9 | -0.9 |
| Distance traveled after self-admin | 0.6 | 0.7 | 1.9 | 0.3 | -0.4 | -0.0 | 1.2 | 0.1 | 1.4 | 1.2 |
| Delta time in open arm before/after self-admin | 0.6 | 0.6 | 0.8 | 0.8 | -0.9 | -0.9 | 0.8 | 0.0 | 0.8 | 0.7 |
| Diff in mean of infusions in LGA sessions | 0.6 | 0.7 | 1.4 | 1.1 | -1.1 | -0.5 | 0.2 | 1.2 | 0.6 | 0.5 |
| Distance moved, locomotor task time 1 | 0.6 | 0.6 | 1.3 | 0.7 | -0.7 | -1.1 | 0.7 | 1.1 | 0.4 | 0.3 |
| Bouts of movement, locomotor time 2 | 0.6 | 0.7 | 2.9 | 0.8 | -0.8 | -0.4 | 0.4 | 1.7 | 0.3 | 0.3 |
| Vertical activity count, locomotor time 2 | 0.6 | 0.6 | 1.3 | -0.5 | 0.5 | 0.6 | 1.2 | 0.6 | 0.9 | 1.0 |
| Extensor digitorum longus weight | 0.5 | 2.0 | 5.1 | -1.7 | 1.7 | 2.3 | 0.8 | 1.2 | 0.4 | 0.7 |
| Delay discounting water rate 18 sec | 0.5 | 0.6 | 1.3 | -1.1 | 1.1 | 0.5 | 0.7 | 0.7 | 0.5 | 0.6 |
| Locomotor activity | 0.5 | 0.8 | 1.1 | 1.1 | -1.1 | -0.2 | 1.0 | 0.3 | 1.0 | 1.0 |
| Condit. Reinf. inactive responses | 0.5 | 0.6 | 0.7 | 0.7 | -0.7 | -0.8 | 0.8 | 0.8 | 0.8 | 0.8 |
| Pavlov. Cond. change in total contacts | 0.5 | 0.7 | 1.6 | -0.1 | 0.1 | 0.4 | 1.2 | 0.7 | 1.2 | 1.3 |
| Pavlov. Cond. response bias | 0.5 | 0.7 | 1.5 | -0.3 | 0.3 | 0.8 | 1.2 | 0.4 | 1.2 | 1.2 |
| Incentive Sensitization - Responses | 0.5 | 0.5 | 1.1 | -0.8 | 0.8 | 1.1 | -0.3 | -0.9 | -0.2 | -0.2 |
| Incentive Sensitization - Breakpoint | 0.5 | 0.5 | 1.1 | -0.7 | 0.7 | 1.0 | -0.4 | -0.9 | -0.3 | -0.2 |
| Locomotion velocity, hab. session 1 | 0.5 | 0.7 | 1.3 | -1.0 | 0.9 | 1.1 | 0.8 | 0.0 | 0.8 | 0.9 |
| Total zone transitions, hab. session 2 | 0.5 | 0.7 | 1.3 | -0.7 | 0.7 | 0.5 | 0.9 | 1.1 | 0.8 | 0.9 |
| Delta time in closed arm before/after self-admin | 0.5 | 0.5 | 1.1 | 0.2 | -0.2 | -0.4 | -0.8 | 1.1 | -0.8 | -0.9 |
| Sum of active levers in priming session hrs 5-6 | 0.5 | 0.5 | 2.3 | 0.4 | -0.4 | 0.7 | -0.5 | -1.5 | -0.0 | 0.0 |
| Fecal boli incidents, locomotor time 1 | 0.5 | 0.6 | 1.4 | 0.1 | -0.2 | 0.6 | 1.0 | 0.3 | 1.1 | 1.2 |
| Cu content in liver | 0.5 | 0.6 | 1.5 | 0.3 | -0.3 | -0.7 | -0.8 | -1.2 | -0.8 | -0.9 |
| Right kidney weight | 0.4 | 1.2 | 3.4 | -1.5 | 1.5 | 1.8 | -0.3 | 0.1 | -0.8 | -0.4 |
| Indifference point function ln k | 0.4 | 0.6 | 1.8 | 0.6 | -0.6 | -1.2 | 0.4 | 1.4 | 0.3 | 0.3 |
| Indifference point function log k | 0.4 | 0.6 | 1.8 | 0.6 | -0.6 | -1.2 | 0.4 | 1.4 | 0.3 | 0.3 |
| Locomotor testing distance | 0.4 | 0.7 | 1.1 | 0.5 | -0.5 | 0.3 | 1.0 | 1.0 | 0.9 | 1.0 |
| Reaction time premature initiation rate | 0.4 | 0.5 | 1.3 | 1.2 | -1.2 | -0.6 | 0.0 | 0.7 | 0.1 | -0.0 |
| Social responses | 0.4 | 0.5 | 2.4 | 0.5 | -0.5 | -0.9 | 0.1 | 1.6 | -0.2 | -0.2 |
| Cocaine response after cond. corrected | 0.4 | 0.4 | 1.0 | 0.8 | -0.8 | -1.0 | -0.5 | 0.1 | -0.4 | -0.5 |
| Intermitt. access day 15 inactive lever presses | 0.4 | 0.5 | 0.9 | -0.5 | 0.5 | -0.5 | 0.9 | 0.3 | 0.9 | 0.8 |
| Intermittent access day 1 locomotion | 0.4 | 0.4 | 0.8 | -0.1 | 0.1 | -0.1 | 0.6 | 0.9 | 0.9 | 0.8 |
| Intermittent access total locomotion | 0.4 | 0.4 | 0.9 | 0.1 | -0.1 | -0.4 | 0.7 | 0.7 | 0.9 | 0.8 |
| Progressive ratio test 1 breakpoint | 0.4 | 0.4 | 1.3 | -1.1 | 1.1 | 0.8 | -0.0 | -0.2 | -0.0 | 0.0 |
| Compulsive drug intake | 0.4 | 0.4 | 0.9 | -0.9 | 0.9 | 0.7 | 0.5 | -0.3 | -0.2 | -0.1 |
| One hour access (0.3 mA shock) | 0.4 | 0.5 | 1.2 | -1.1 | 1.1 | 1.0 | -0.0 | -0.4 | 0.1 | 0.1 |
| Locomotion velocity, session 8 | 0.4 | 0.5 | 1.8 | 0.0 | -0.0 | -0.7 | 0.7 | 1.4 | 0.6 | 0.6 |
| Condit. Reinf. inactive responses | 0.4 | 0.5 | 1.4 | -0.8 | 0.8 | 1.2 | -0.3 | -0.7 | -0.1 | -0.1 |
| Time to tail flick, vehicle, after self-admin | 0.4 | 0.4 | 1.9 | 0.5 | -0.5 | -0.2 | 0.2 | 1.4 | 0.4 | 0.4 |
| Delta time to tail flick, vehicle, before/after SA | 0.4 | 0.4 | 2.0 | 0.0 | -0.1 | 0.6 | 0.1 | 1.4 | 0.2 | 0.3 |
| Seeking ratio, punishment vs. effort | 0.4 | 0.5 | 1.0 | -0.1 | 0.1 | -1.0 | -1.0 | -0.1 | -0.8 | -1.0 |
| Rb content in liver | 0.4 | 0.5 | 1.3 | -1.1 | 1.1 | 0.4 | 0.5 | -0.1 | 0.4 | 0.4 |
| Reaction time mean minus median | 0.3 | 0.3 | 1.0 | 1.0 | -1.0 | -0.3 | 0.1 | -0.4 | 0.2 | 0.1 |
| Reaction time omissions | 0.3 | 0.4 | 0.6 | 0.5 | -0.5 | -0.6 | 0.7 | 0.6 | 0.8 | 0.7 |
| Reaction time false alarm rate | 0.3 | 0.4 | 0.7 | 0.4 | -0.4 | 0.5 | -0.8 | -0.7 | -0.8 | -0.7 |
| Conditioned reinforcement - actives | 0.3 | 0.3 | 0.7 | 0.1 | -0.2 | -0.3 | 0.6 | 0.9 | 0.7 | 0.6 |
| Intermittent access intake day 1-15 change | 0.3 | 0.3 | 0.8 | 0.6 | -0.6 | -0.9 | 0.5 | -0.1 | 0.5 | 0.3 |
| Progressive ratio test 2 breakpoint | 0.3 | 0.3 | 0.7 | -0.7 | 0.7 | 0.9 | 0.3 | -0.1 | 0.4 | 0.4 |
| Total sessions with >9 infusions | 0.3 | 0.3 | 0.5 | 0.3 | -0.3 | -0.2 | 0.6 | 0.7 | 0.7 | 0.7 |
| One hour access (shock baseline) | 0.3 | 0.3 | 0.8 | -0.7 | 0.7 | 0.9 | -0.2 | 0.4 | 0.3 | 0.3 |
| Condit. Reinf. lever presses | 0.3 | 0.5 | 0.9 | 0.2 | -0.2 | 0.3 | 0.8 | 0.7 | 0.9 | 0.9 |
| Total locomotion distance, hab. session 1 | 0.3 | 0.5 | 0.8 | -0.8 | 0.8 | 0.9 | 0.6 | 0.1 | 0.5 | 0.6 |
| Time in familiar zone, hab. session 2 | 0.3 | 0.3 | 0.6 | 0.6 | -0.7 | -0.3 | 0.3 | 0.8 | 0.4 | 0.4 |
| Pavlov. Cond. intertrial magazine entries | 0.3 | 0.4 | 0.9 | -0.8 | 0.8 | 0.9 | 0.5 | 0.1 | 0.4 | 0.5 |
| Bone surface | 0.3 | 0.5 | 1.3 | -1.2 | 1.2 | 0.8 | -0.2 | -0.2 | -0.4 | -0.3 |
| Ambulatory time after self-admin | 0.3 | 0.3 | 0.6 | 0.4 | -0.5 | -0.4 | 0.7 | -0.2 | 0.8 | 0.6 |
| Time >=10cm from walls, locomotor time 1 | 0.3 | 0.3 | 0.6 | -0.4 | 0.4 | -0.6 | 0.6 | 0.8 | 0.5 | 0.4 |
| Total resting periods, locomotor time 1 | 0.3 | 0.3 | 0.9 | 0.9 | -0.9 | -0.5 | -0.4 | 0.3 | -0.1 | -0.2 |
| Run reversals in cocaine runway, females | 0.3 | 0.3 | 0.8 | 0.0 | -0.0 | 0.3 | 0.6 | 0.9 | 0.6 | 0.7 |
| Na content in liver | 0.3 | 0.3 | 1.1 | 0.7 | -0.7 | -1.0 | 0.0 | 0.3 | 0.2 | 0.0 |
| Tibialis anterior weight | 0.2 | 0.7 | 2.2 | -1.1 | 1.1 | 1.5 | 0.0 | 0.1 | -0.1 | 0.1 |
| Food consumed during 24 hour testing period | 0.2 | 0.2 | 0.3 | -0.6 | 0.6 | 0.3 | -0.5 | -0.2 | -0.5 | -0.6 |
| Delay discounting total patch changes 12 sec | 0.2 | 0.2 | 0.4 | 0.6 | -0.6 | -0.3 | -0.6 | -0.4 | -0.2 | -0.3 |
| Delay discounting total patch changes 18 sec | 0.2 | 0.3 | 0.5 | 0.5 | -0.5 | -0.7 | 0.5 | 0.4 | 0.6 | 0.5 |
| Delay discounting time to switch 0 sec | 0.2 | 0.2 | 0.5 | 0.6 | -0.6 | -0.1 | 0.2 | 0.7 | 0.4 | 0.4 |
| Delay discounting water rate 6 sec | 0.2 | 0.3 | 0.4 | 0.3 | -0.4 | -0.4 | 0.6 | 0.3 | 0.7 | 0.6 |
| Reaction time mean | 0.2 | 0.2 | 0.7 | -0.5 | 0.5 | 0.8 | -0.1 | -0.5 | -0.2 | -0.1 |
| Reaction time mean AUC | 0.2 | 0.3 | 0.7 | -0.6 | 0.6 | 0.8 | 0.3 | -0.1 | 0.3 | 0.4 |
| Median of all reaction times | 0.2 | 0.2 | 0.5 | -0.7 | 0.7 | 0.7 | -0.1 | -0.4 | -0.2 | -0.1 |
| Std. dev. reaction times | 0.2 | 0.3 | 0.6 | 0.7 | -0.8 | -0.2 | 0.5 | 0.2 | 0.7 | 0.6 |
| Condit. Reinf. lever presses | 0.2 | 0.3 | 0.5 | -0.5 | 0.5 | 0.4 | 0.7 | -0.0 | 0.5 | 0.6 |
| Conditioned reinforcement - inactives | 0.2 | 0.2 | 0.3 | 0.3 | -0.3 | -0.4 | 0.5 | -0.4 | 0.5 | 0.4 |
| Intermittent access total infusions | 0.2 | 0.2 | 0.4 | -0.6 | 0.6 | 0.3 | 0.3 | 0.6 | 0.4 | 0.3 |
| Progressive ratio test 1 active lever presses | 0.2 | 0.2 | 0.5 | -0.7 | 0.7 | 0.4 | 0.2 | 0.1 | 0.2 | 0.2 |
| Progressive ratio test 1 inactive lever presses | 0.2 | 0.2 | 0.6 | -0.8 | 0.8 | -0.0 | 0.1 | -0.4 | -0.2 | -0.2 |
| Progressive ratio test 2 active lever presses | 0.2 | 0.2 | 0.4 | -0.5 | 0.5 | 0.6 | 0.1 | -0.4 | 0.3 | 0.3 |
| Short access total infusions | 0.2 | 0.2 | 0.4 | 0.5 | -0.5 | -0.6 | -0.4 | 0.2 | -0.2 | -0.3 |
| Time in familiar zone, hab. session 1 | 0.2 | 0.2 | 0.4 | 0.2 | -0.2 | -0.0 | -0.7 | -0.5 | -0.5 | -0.5 |
| Total zone transitions, hab. session 1 | 0.2 | 0.2 | 0.4 | 0.4 | -0.4 | -0.4 | 0.4 | 0.5 | 0.7 | 0.6 |
| Bone: apparent density | 0.2 | 0.3 | 0.6 | -0.8 | 0.8 | 0.1 | -0.4 | 0.5 | -0.5 | -0.5 |
| Bone volume | 0.2 | 0.4 | 0.9 | -1.0 | 1.0 | 0.7 | -0.3 | 0.0 | -0.5 | -0.4 |
| Bone: connectivity density | 0.2 | 0.2 | 1.1 | -0.3 | 0.3 | -0.5 | 0.3 | 1.0 | 0.2 | 0.2 |
| Bone: post-yield work | 0.2 | 0.3 | 0.4 | -0.6 | 0.6 | 0.6 | 0.6 | 0.4 | 0.4 | 0.6 |
| Breakpoint value in progressive ratio session | 0.2 | 0.3 | 0.4 | 0.6 | -0.5 | 0.6 | 0.5 | -0.5 | 0.4 | 0.6 |
| Time in closed arm before self-admin | 0.2 | 0.2 | 0.5 | 0.3 | -0.3 | 0.1 | 0.4 | -0.7 | 0.4 | 0.4 |
| Time to tail flick, vehicle, before self-admin | 0.2 | 0.2 | 0.4 | -0.1 | 0.1 | -0.5 | 0.4 | -0.5 | 0.6 | 0.5 |
| Total heroin consumption | 0.2 | 0.3 | 1.0 | -0.2 | 0.2 | 0.8 | -0.0 | -1.0 | -0.2 | 0.1 |
| Delay disc. indifference point, 2s delay | 0.2 | 0.2 | 0.4 | 0.6 | -0.6 | -0.5 | 0.2 | 0.4 | 0.5 | 0.5 |
| Bouts of movement, locomotor time 1 | 0.2 | 0.2 | 0.4 | 0.7 | -0.6 | -0.1 | -0.4 | 0.4 | -0.1 | -0.2 |
| Vertical activity count, locomotor time 1 | 0.2 | 0.2 | 0.5 | -0.3 | 0.3 | -0.2 | 0.7 | 0.7 | 0.5 | 0.5 |
| Rest time, locomotor task time 2 | 0.2 | 0.2 | 0.8 | -0.2 | 0.2 | 0.9 | 0.1 | 0.4 | 0.3 | 0.4 |
| Distance moved, locomotor task time 2 | 0.2 | 0.2 | 0.8 | 0.4 | -0.4 | -0.9 | 0.0 | 0.6 | -0.1 | -0.3 |
| Food seeking constrained by brief footshock | 0.2 | 0.3 | 0.8 | 0.7 | -0.7 | -0.9 | -0.4 | 0.0 | -0.1 | -0.3 |
| Co content in liver | 0.2 | 0.2 | 0.3 | 0.5 | -0.5 | -0.3 | 0.5 | 0.5 | 0.5 | 0.5 |
| K content in liver | 0.2 | 0.2 | 0.3 | -0.6 | 0.5 | -0.1 | 0.5 | -0.1 | 0.5 | 0.4 |
| Se content in liver | 0.2 | 0.2 | 1.0 | 0.3 | -0.3 | -1.0 | -0.3 | -0.1 | -0.1 | -0.3 |
| Zn content in liver | 0.2 | 0.2 | 0.5 | 0.1 | -0.1 | 0.1 | 0.6 | 0.7 | 0.6 | 0.6 |
| Liver weight, left | 0.1 | 0.1 | 0.5 | 0.2 | -0.2 | 0.5 | -0.3 | -0.7 | 0.0 | 0.2 |
| Number of licking bursts | 0.1 | 0.1 | 0.2 | -0.4 | 0.4 | -0.0 | 0.3 | 0.4 | 0.2 | 0.1 |
| Indifference point 0 sec | 0.1 | 0.2 | 0.9 | 0.3 | -0.3 | -1.0 | -0.2 | 0.0 | -0.1 | -0.1 |
| Delay discounting total patch changes 0 sec | 0.1 | 0.2 | 1.1 | 0.3 | -0.3 | -1.0 | -0.0 | 0.1 | 0.0 | -0.1 |
| Delay discounting total patch changes 24 sec | 0.1 | 0.1 | 0.2 | -0.1 | 0.1 | -0.3 | -0.4 | -0.3 | -0.3 | -0.4 |
| Delay discounting total patch changes 6 sec | 0.1 | 0.2 | 0.5 | -0.2 | 0.2 | 0.0 | -0.7 | -0.6 | -0.5 | -0.6 |
| Delay discounting water rate 0 sec | 0.1 | 0.1 | 0.2 | -0.5 | 0.4 | -0.5 | 0.3 | -0.1 | 0.2 | 0.1 |
| Reaction time num false alarms | 0.1 | 0.2 | 0.7 | -0.3 | 0.3 | 0.8 | -0.1 | -0.2 | -0.4 | -0.2 |
| Social time | 0.1 | 0.1 | 0.2 | -0.3 | 0.3 | 0.4 | 0.4 | 0.5 | -0.1 | 0.1 |
| Intermitt. access day 1 inactive lever presses | 0.1 | 0.1 | 0.1 | -0.2 | 0.2 | 0.4 | -0.1 | -0.3 | -0.3 | -0.3 |
| Intermittent access day 15 total infusions | 0.1 | 0.2 | 0.4 | -0.3 | 0.3 | 0.1 | 0.5 | 0.2 | 0.6 | 0.5 |
| Intermittent access terminal intake (last 3 days) | 0.1 | 0.1 | 0.2 | -0.3 | 0.3 | 0.4 | -0.0 | -0.5 | 0.2 | 0.1 |
| Intermittent access day 15 total locomotion | 0.1 | 0.1 | 0.3 | -0.2 | 0.2 | -0.5 | 0.4 | 0.1 | 0.5 | 0.4 |
| Lifetime Intake | 0.1 | 0.1 | 0.3 | -0.1 | 0.1 | -0.1 | 0.0 | 0.6 | 0.2 | 0.1 |
| Progressive ratio test 2 inactive lever presses | 0.1 | 0.1 | 0.5 | -0.2 | 0.2 | -0.1 | -0.4 | -0.7 | -0.3 | -0.3 |
| Number of responses in last shaping day | 0.1 | 0.2 | 0.2 | -0.5 | 0.5 | -0.3 | -0.5 | -0.3 | -0.3 | -0.3 |
| Stereotopy head waving bouts, day 3 | 0.1 | 0.1 | 0.3 | 0.2 | -0.2 | -0.0 | -0.6 | -0.1 | -0.5 | -0.5 |
| Stereotopy head waving duration, day 3 | 0.1 | 0.1 | 0.3 | -0.3 | 0.3 | 0.5 | -0.0 | -0.1 | -0.1 | -0.0 |
| Degree of sensitization distance | 0.1 | 0.1 | 0.3 | -0.5 | 0.5 | 0.4 | 0.1 | -0.2 | 0.3 | 0.2 |
| Time in novel zone, hab. session 1 | 0.1 | 0.1 | 0.2 | 0.1 | -0.1 | -0.4 | 0.0 | 0.4 | -0.0 | -0.1 |
| Bone: trabecular number | 0.1 | 0.2 | 0.5 | -0.1 | 0.1 | -0.3 | -0.7 | 0.3 | -0.6 | -0.7 |
| Delay disc. indifference point, 0s delay | 0.1 | 0.2 | 0.4 | -0.1 | 0.1 | -0.5 | -0.6 | 0.3 | -0.4 | -0.4 |
| Rest time, locomotor task time 1 | 0.1 | 0.1 | 0.2 | 0.2 | -0.2 | 0.4 | -0.1 | -0.5 | 0.3 | 0.3 |
| Locomotion in novel chamber | 0.1 | 0.2 | 0.8 | -0.2 | 0.2 | 0.2 | -0.2 | 0.9 | -0.3 | -0.2 |
| Latency to leave start box in cocaine runway, M | 0.1 | 0.1 | 0.5 | 0.2 | -0.2 | 0.7 | 0.1 | 0.1 | 0.0 | 0.1 |
| Indifference point AUC | 0.0 | 0.1 | 0.3 | -0.0 | 0.0 | 0.6 | -0.2 | -0.1 | -0.0 | -0.1 |
| Delay discounting water rate 12 sec | 0.0 | 0.0 | 0.2 | -0.2 | 0.2 | -0.1 | 0.1 | 0.4 | 0.1 | 0.1 |
| Reaction time mean minus median AUC | 0.0 | 0.1 | 0.1 | 0.3 | -0.3 | -0.1 | 0.1 | -0.3 | 0.2 | 0.1 |
| Reaction time num false alarms AUC | 0.0 | 0.1 | 0.2 | 0.2 | -0.1 | 0.5 | 0.2 | 0.3 | 0.1 | 0.2 |
| Short access day 10 total infusions | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | 0.4 | -0.2 | -0.1 | 0.0 | -0.1 |
| Time in novel zone, hab. session 2 | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | -0.2 | -0.1 | -0.2 | -0.1 | -0.2 |
| Time in open arm after self-admin | 0.0 | 0.0 | 0.2 | -0.2 | 0.2 | -0.1 | -0.2 | 0.4 | -0.2 | -0.1 |
| Mn content in liver | 0.0 | 0.1 | 0.3 | -0.1 | 0.1 | -0.3 | -0.2 | -0.5 | 0.1 | -0.0 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.