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chr3:126,160,536-128,707,024

Trait: Body weight

Best TWAS P=5.523679e-12 · Best GWAS P=2.20081e-12 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	AABR07054000.1	alternative polyA	ENSRNOT00000072928	0.26	0.13	blup	1836	0.16	2.6e-17	5.6	-6.1	8.0e-10	-0.93	0.46	0.54	FALSE
2	Adipose	AABR07054000.1	alternative polyA	ENSRNOT00000110455	0.08	0.06	lasso	22	0.06	5.7e-07	5.6	5.6	1.9e-08	0.94	0.44	0.56	FALSE
3	Adipose	AABR07054000.1	alternative polyA	ENSRNOT00000117007	0.07	0.04	top1	1	0.04	1.2e-05	5.8	5.8	6.8e-09	0.79	0.28	0.03	FALSE
4	Adipose	AABR07054000.1	gene expression	ENSRNOG00000050784	0.42	0.30	top1	1	0.30	4.0e-34	6.0	6.0	2.1e-09	0.95	0.88	0.12	TRUE
5	Adipose	AABR07054000.1	isoform ratio	ENSRNOT00000072928	0.28	0.15	lasso	59	0.19	8.1e-21	5.7	-6.0	2.2e-09	-0.90	0.60	0.40	FALSE
6	Adipose	AABR07054000.1	isoform ratio	ENSRNOT00000110455	0.09	0.06	blup	1836	0.06	1.8e-07	6.7	6.4	2.0e-10	0.94	0.45	0.55	FALSE
7	Adipose	AABR07054000.1	isoform ratio	ENSRNOT00000117007	0.15	0.08	enet	471	0.09	1.3e-10	5.8	6.0	2.0e-09	0.88	0.67	0.33	FALSE
8	Adipose	Esf1	mRNA stability	ENSRNOG00000004777	0.17	0.06	blup	1671	0.07	2.9e-08	-4.9	5.9	4.2e-09	0.58	1.00	0.00	FALSE
9	Adipose	Ndufaf5	mRNA stability	ENSRNOG00000004784	0.04	0.00	enet	54	0.01	1.5e-02	5.5	5.8	5.1e-09	0.83	0.44	0.48	FALSE
10	BLA	AABR07054000.1	alternative polyA	ENSRNOT00000072928	0.14	0.08	blup	1836	0.09	1.9e-05	6.2	-6.7	1.9e-11	-0.91	0.46	0.54	FALSE
11	BLA	AABR07054000.1	alternative polyA	ENSRNOT00000117007	0.12	0.08	top1	1	0.08	7.2e-05	5.9	5.9	2.8e-09	0.89	0.10	0.04	FALSE
12	BLA	Flrt3	gene expression	ENSRNOG00000004874	0.06	0.04	top1	1	0.04	5.4e-03	5.8	-5.8	7.9e-09	-0.65	0.08	0.04	FALSE
13	BLA	AABR07054000.1	gene expression	ENSRNOG00000050784	0.09	0.02	enet	49	0.03	1.5e-02	5.8	-6.9	5.5e-12	-0.78	0.62	0.24	TRUE
14	BLA	AABR07054000.1	isoform ratio	ENSRNOT00000072928	0.15	0.14	blup	1836	0.15	2.4e-08	6.1	-6.6	4.4e-11	-0.93	0.57	0.43	FALSE
15	BLA	AABR07054000.1	isoform ratio	ENSRNOT00000117007	0.11	0.07	top1	1	0.07	1.1e-04	5.9	5.9	2.8e-09	0.92	0.16	0.04	FALSE
16	BLA	Ndufaf5	intron excision ratio	chr3:127508215:127509498	0.80	0.43	enet	162	0.44	6.0e-26	-4.9	5.6	2.8e-08	0.78	1.00	0.00	FALSE
17	BLA	Ndufaf5	intron excision ratio	chr3:127508256:127509498	0.79	0.43	enet	169	0.44	7.1e-26	-4.9	-5.5	4.0e-08	-0.77	1.00	0.00	FALSE
18	BLA	AABR07054000.1	intron excision ratio	chr3:127725722:127779334	0.06	0.03	top1	1	0.03	1.6e-02	6.5	6.5	1.0e-10	0.94	0.07	0.04	FALSE
19	BLA	Tasp1	mRNA stability	ENSRNOG00000004493	0.11	0.08	lasso	5	0.08	2.9e-05	5.6	-5.6	1.8e-08	-0.94	0.49	0.50	FALSE
20	Brain	AABR07054000.1	alternative polyA	ENSRNOT00000072928	0.03	0.02	top1	1	0.02	4.5e-03	5.7	-5.7	9.1e-09	-0.96	0.06	0.03	FALSE
21	Brain	Sptlc3	gene expression	ENSRNOG00000004443	0.06	0.03	lasso	5	0.05	1.0e-05	-5.1	-5.2	1.6e-07	-0.32	0.60	0.39	TRUE
22	Brain	AABR07054000.1	gene expression	ENSRNOG00000050784	0.04	0.05	top1	1	0.05	2.2e-05	6.5	-6.5	9.6e-11	-0.83	0.11	0.21	FALSE
23	Brain	Ism1	gene expression	ENSRNOG00000063262	0.05	0.03	enet	32	0.04	8.7e-05	5.4	-6.0	2.2e-09	-0.88	0.47	0.52	FALSE
24	Brain	AABR07054000.1	isoform ratio	ENSRNOT00000072928	0.04	0.04	top1	1	0.04	6.8e-05	5.8	-5.8	6.2e-09	-0.95	0.29	0.04	FALSE
25	Brain	AABR07054000.1	isoform ratio	ENSRNOT00000117007	0.04	0.02	top1	1	0.02	3.2e-03	5.5	5.5	3.1e-08	0.96	0.07	0.03	FALSE
26	Brain	Tasp1	mRNA stability	ENSRNOG00000004493	0.13	0.14	lasso	26	0.14	7.5e-13	5.1	-5.1	2.9e-07	-0.92	0.71	0.29	FALSE
27	Eye	Ism1	gene expression	ENSRNOG00000063262	0.59	0.02	blup	1704	0.07	3.4e-02	5.6	5.9	3.1e-09	0.87	0.22	0.23	FALSE
28	IL	AABR07054000.1	gene expression	ENSRNOG00000050784	0.21	0.05	top1	1	0.04	3.1e-02	6.3	-6.3	2.2e-10	-0.94	0.09	0.05	FALSE
29	IL	AABR07054000.1	isoform ratio	ENSRNOT00000117007	0.18	0.11	top1	1	0.11	1.2e-03	5.9	5.9	2.7e-09	0.88	0.10	0.05	FALSE
30	IL	Tasp1	intron excision ratio	chr3:127355890:127385049	0.25	0.01	enet	9	0.06	1.6e-02	-4.6	-5.6	2.9e-08	-0.56	0.43	0.07	TRUE
31	IL	Tasp1	mRNA stability	ENSRNOG00000004493	0.14	0.07	blup	1685	0.10	2.2e-03	5.6	-6.1	1.0e-09	-0.92	0.39	0.39	FALSE
32	IL	Ndufaf5	mRNA stability	ENSRNOG00000004784	0.19	0.08	top1	1	0.08	6.8e-03	6.2	6.2	7.1e-10	0.95	0.09	0.06	FALSE
33	LHb	AABR07054000.1	gene expression	ENSRNOG00000050784	0.23	0.15	enet	97	0.17	9.3e-05	5.9	-5.9	2.9e-09	-0.96	0.32	0.64	FALSE
34	LHb	AABR07054000.1	intron excision ratio	chr3:127725722:127747858	0.14	0.05	top1	1	0.05	2.9e-02	6.1	-6.1	1.2e-09	-0.75	0.09	0.05	FALSE
35	LHb	AABR07054000.1	intron excision ratio	chr3:127725722:127779334	0.13	0.03	top1	1	0.03	6.5e-02	6.1	6.1	1.2e-09	0.75	0.09	0.05	FALSE
36	Liver	Flrt3	alternative TSS	ENSRNOT00000006454	0.03	0.01	blup	2101	0.01	2.0e-02	5.8	6.6	3.8e-11	0.94	0.44	0.20	FALSE
37	Liver	Ndufaf5	gene expression	ENSRNOG00000004784	0.17	0.09	lasso	21	0.10	1.1e-10	-5.0	5.1	2.9e-07	0.49	1.00	0.00	FALSE
38	Liver	Flrt3	isoform ratio	ENSRNOT00000006454	0.03	0.01	blup	2101	0.01	6.6e-02	5.8	6.6	5.6e-11	0.96	0.40	0.18	FALSE
39	Liver	AABR07054000.1	intron excision ratio	chr3:127747955:127748961	0.03	0.01	blup	1836	0.01	1.4e-02	6.7	-5.6	2.4e-08	-0.89	0.33	0.38	FALSE
40	Liver	AABR07054000.1	intron excision ratio	chr3:127747955:127749007	0.03	0.01	enet	25	0.02	5.2e-03	5.6	6.7	2.0e-11	0.86	0.37	0.44	FALSE
41	NAcc	AABR07054000.1	alternative polyA	ENSRNOT00000072928	0.08	0.03	top1	1	0.03	1.7e-03	5.5	-5.5	3.0e-08	-0.96	0.16	0.03	FALSE
42	NAcc	AABR07054000.1	alternative polyA	ENSRNOT00000110455	0.11	0.00	blup	1836	0.01	2.5e-02	5.7	6.4	1.6e-10	0.76	0.62	0.15	FALSE
43	NAcc	Tasp1	gene expression	ENSRNOG00000004493	0.05	0.04	top1	1	0.04	6.8e-04	5.6	5.6	2.0e-08	0.94	0.08	0.04	FALSE
44	NAcc	Ndufaf5	gene expression	ENSRNOG00000004784	0.06	0.01	blup	1671	0.03	3.7e-03	5.7	6.5	7.1e-11	0.83	0.49	0.27	FALSE
45	NAcc	AABR07054000.1	gene expression	ENSRNOG00000050784	0.10	0.08	lasso	5	0.09	1.9e-07	6.6	-6.1	8.9e-10	-0.95	0.64	0.36	FALSE
46	NAcc	AABR07054000.1	isoform ratio	ENSRNOT00000072928	0.07	0.01	blup	1836	0.03	5.6e-03	5.5	-6.4	1.4e-10	-0.92	0.60	0.35	FALSE
47	NAcc	AABR07054000.1	isoform ratio	ENSRNOT00000117007	0.06	0.04	blup	1836	0.05	2.4e-04	6.2	6.0	1.6e-09	0.95	0.53	0.46	FALSE
48	NAcc	Tasp1	intron excision ratio	chr3:127385117:127399392	0.07	0.02	top1	1	0.02	1.0e-02	5.6	-5.6	2.0e-08	-0.93	0.28	0.11	FALSE
49	NAcc	Ndufaf5	mRNA stability	ENSRNOG00000004784	0.10	0.05	lasso	36	0.07	6.6e-06	-4.6	6.0	1.8e-09	0.82	0.52	0.47	FALSE
50	OFC	AABR07054000.1	alternative polyA	ENSRNOT00000072928	0.21	0.10	top1	1	0.10	2.4e-03	5.9	-5.9	4.0e-09	-0.94	0.09	0.05	FALSE
51	OFC	Ism1	gene expression	ENSRNOG00000063262	0.24	0.12	top1	1	0.12	1.1e-03	5.6	-5.6	1.8e-08	-0.93	0.09	0.08	FALSE
52	OFC	Ndufaf5	intron excision ratio	chr3:127508215:127509498	0.58	0.21	blup	1669	0.23	4.6e-06	-4.7	5.1	2.8e-07	0.44	0.95	0.01	FALSE
53	OFC	Ndufaf5	intron excision ratio	chr3:127508256:127509498	0.61	0.21	blup	1669	0.24	1.6e-06	-4.7	-5.2	1.9e-07	-0.47	0.97	0.01	FALSE
54	OFC	Tasp1	mRNA stability	ENSRNOG00000004493	0.17	0.11	top1	1	0.11	1.2e-03	6.0	-6.0	2.3e-09	-0.94	0.09	0.06	FALSE
55	PL	AABR07054000.1	alternative polyA	ENSRNOT00000072928	0.17	0.17	top1	1	0.17	1.1e-12	6.2	-6.2	7.7e-10	-0.95	0.73	0.27	FALSE
56	PL	AABR07054000.1	alternative polyA	ENSRNOT00000117007	0.08	0.08	lasso	13	0.08	5.7e-07	6.1	6.1	8.3e-10	0.96	0.37	0.63	FALSE
57	PL	Tasp1	gene expression	ENSRNOG00000004493	0.04	0.01	enet	8	0.02	1.0e-02	-4.8	-6.2	7.3e-10	-0.65	0.41	0.38	FALSE
58	PL	Ndufaf5	gene expression	ENSRNOG00000004784	0.16	0.07	lasso	24	0.08	5.9e-07	-4.9	6.0	2.6e-09	0.71	0.92	0.08	FALSE
59	PL	AABR07054000.1	gene expression	ENSRNOG00000050784	0.09	0.11	top1	1	0.11	6.0e-09	5.9	-5.9	2.8e-09	-0.89	0.89	0.09	FALSE
60	PL	AABR07054000.1	isoform ratio	ENSRNOT00000072928	0.21	0.15	top1	1	0.15	2.5e-11	6.2	-6.2	7.7e-10	-0.95	0.73	0.27	FALSE
61	PL	AABR07054000.1	isoform ratio	ENSRNOT00000117007	0.10	0.12	top1	1	0.12	3.1e-09	6.2	6.2	6.5e-10	0.96	0.69	0.30	FALSE
62	PL	Tasp1	intron excision ratio	chr3:127385117:127399392	0.04	0.03	blup	1687	0.04	1.1e-03	5.8	-5.9	4.4e-09	-0.91	0.45	0.45	FALSE
63	PL	AABR07054000.1	intron excision ratio	chr3:127725722:127747858	0.04	0.03	top1	1	0.03	1.8e-03	5.9	-5.9	2.8e-09	-0.90	0.07	0.03	FALSE
64	PL	AABR07054000.1	intron excision ratio	chr3:127725722:127779334	0.04	0.03	top1	1	0.03	1.6e-03	5.9	5.9	2.8e-09	0.89	0.08	0.04	FALSE
65	PL	Tasp1	mRNA stability	ENSRNOG00000004493	0.04	0.04	blup	1687	0.04	5.9e-04	5.8	-5.8	7.3e-09	-0.91	0.49	0.48	FALSE
66	PL	Ndufaf5	mRNA stability	ENSRNOG00000004784	0.18	0.09	lasso	50	0.13	4.7e-10	-4.6	6.0	1.6e-09	0.77	0.84	0.16	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.