Best TWAS P=5.52e-12 · Best GWAS P=2.20e-12 conditioned to 1.00e+00
Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
---|---|---|---|---|---|---|---|---|---|---|---|
Adipose | AABR07054000.1 | alternative polyA | ENSRNOT00000072928 | 0.26 | 1836 | 0.16 | 2.6e-17 | -6.15 | 8.00e-10 | 0.54 | FALSE |
Adipose | AABR07054000.1 | alternative polyA | ENSRNOT00000110455 | 0.08 | 22 | 0.06 | 5.7e-07 | 5.62 | 1.89e-08 | 0.56 | FALSE |
Adipose | AABR07054000.1 | alternative polyA | ENSRNOT00000117007 | 0.07 | 1 | 0.04 | 1.2e-05 | 5.8 | 6.80e-09 | 0.03 | FALSE |
Adipose | AABR07054000.1 | gene expression | ENSRNOG00000050784 | 0.42 | 1 | 0.3 | 4.0e-34 | 5.99 | 2.10e-09 | 0.12 | TRUE |
Adipose | AABR07054000.1 | isoform ratio | ENSRNOT00000072928 | 0.28 | 59 | 0.19 | 8.1e-21 | -5.98 | 2.19e-09 | 0.4 | FALSE |
Adipose | AABR07054000.1 | isoform ratio | ENSRNOT00000110455 | 0.09 | 1836 | 0.06 | 1.8e-07 | 6.36 | 2.03e-10 | 0.55 | FALSE |
Adipose | AABR07054000.1 | isoform ratio | ENSRNOT00000117007 | 0.15 | 471 | 0.09 | 1.3e-10 | 6 | 2.03e-09 | 0.33 | FALSE |
Adipose | Esf1 | mRNA stability | ENSRNOG00000004777 | 0.17 | 1671 | 0.07 | 2.9e-08 | 5.87 | 4.24e-09 | 0 | FALSE |
Adipose | Ndufaf5 | mRNA stability | ENSRNOG00000004784 | 0.04 | 54 | 0.01 | 1.5e-02 | 5.85 | 5.06e-09 | 0.48 | FALSE |
BLA | AABR07054000.1 | alternative polyA | ENSRNOT00000072928 | 0.14 | 1836 | 0.09 | 1.9e-05 | -6.71 | 1.89e-11 | 0.54 | FALSE |
BLA | AABR07054000.1 | alternative polyA | ENSRNOT00000117007 | 0.12 | 1 | 0.08 | 7.2e-05 | 5.94 | 2.82e-09 | 0.04 | FALSE |
BLA | Flrt3 | gene expression | ENSRNOG00000004874 | 0.06 | 1 | 0.04 | 5.4e-03 | -5.77 | 7.91e-09 | 0.04 | FALSE |
BLA | AABR07054000.1 | gene expression | ENSRNOG00000050784 | 0.09 | 49 | 0.03 | 1.5e-02 | -6.89 | 5.52e-12 | 0.24 | TRUE |
BLA | AABR07054000.1 | isoform ratio | ENSRNOT00000072928 | 0.15 | 1836 | 0.15 | 2.4e-08 | -6.59 | 4.44e-11 | 0.43 | FALSE |
BLA | AABR07054000.1 | isoform ratio | ENSRNOT00000117007 | 0.11 | 1 | 0.07 | 1.1e-04 | 5.94 | 2.82e-09 | 0.04 | FALSE |
BLA | Ndufaf5 | intron excision ratio | chr3:127508215:127509498 | 0.8 | 162 | 0.44 | 6.0e-26 | 5.55 | 2.80e-08 | 0 | FALSE |
BLA | Ndufaf5 | intron excision ratio | chr3:127508256:127509498 | 0.79 | 169 | 0.44 | 7.1e-26 | -5.49 | 3.98e-08 | 0 | FALSE |
BLA | AABR07054000.1 | intron excision ratio | chr3:127725722:127779334 | 0.06 | 1 | 0.03 | 1.6e-02 | 6.47 | 1.00e-10 | 0.04 | FALSE |
BLA | Tasp1 | mRNA stability | ENSRNOG00000004493 | 0.11 | 5 | 0.08 | 2.9e-05 | -5.63 | 1.78e-08 | 0.5 | FALSE |
Brain | AABR07054000.1 | alternative polyA | ENSRNOT00000072928 | 0.03 | 1 | 0.02 | 4.5e-03 | -5.75 | 9.09e-09 | 0.03 | FALSE |
Brain | Sptlc3 | gene expression | ENSRNOG00000004443 | 0.06 | 5 | 0.05 | 1.0e-05 | -5.24 | 1.61e-07 | 0.39 | TRUE |
Brain | AABR07054000.1 | gene expression | ENSRNOG00000050784 | 0.04 | 1 | 0.05 | 2.2e-05 | -6.47 | 9.63e-11 | 0.21 | FALSE |
Brain | Ism1 | gene expression | ENSRNOG00000063262 | 0.05 | 32 | 0.04 | 8.7e-05 | -5.98 | 2.19e-09 | 0.52 | FALSE |
Brain | AABR07054000.1 | isoform ratio | ENSRNOT00000072928 | 0.04 | 1 | 0.04 | 6.8e-05 | -5.81 | 6.15e-09 | 0.04 | FALSE |
Brain | AABR07054000.1 | isoform ratio | ENSRNOT00000117007 | 0.04 | 1 | 0.02 | 3.2e-03 | 5.54 | 3.07e-08 | 0.03 | FALSE |
Brain | Tasp1 | mRNA stability | ENSRNOG00000004493 | 0.13 | 26 | 0.14 | 7.5e-13 | -5.13 | 2.91e-07 | 0.29 | FALSE |
Eye | Ism1 | gene expression | ENSRNOG00000063262 | 0.59 | 1704 | 0.07 | 3.4e-02 | 5.93 | 3.08e-09 | 0.23 | FALSE |
IL | AABR07054000.1 | gene expression | ENSRNOG00000050784 | 0.21 | 1 | 0.04 | 3.1e-02 | -6.35 | 2.16e-10 | 0.05 | FALSE |
IL | AABR07054000.1 | isoform ratio | ENSRNOT00000117007 | 0.18 | 1 | 0.11 | 1.2e-03 | 5.95 | 2.69e-09 | 0.05 | FALSE |
IL | Tasp1 | intron excision ratio | chr3:127355890:127385049 | 0.25 | 9 | 0.06 | 1.6e-02 | -5.55 | 2.86e-08 | 0.07 | TRUE |
IL | Tasp1 | mRNA stability | ENSRNOG00000004493 | 0.14 | 1685 | 0.1 | 2.2e-03 | -6.1 | 1.05e-09 | 0.39 | FALSE |
IL | Ndufaf5 | mRNA stability | ENSRNOG00000004784 | 0.19 | 1 | 0.08 | 6.8e-03 | 6.16 | 7.09e-10 | 0.06 | FALSE |
LHb | AABR07054000.1 | gene expression | ENSRNOG00000050784 | 0.23 | 97 | 0.17 | 9.3e-05 | -5.94 | 2.93e-09 | 0.64 | FALSE |
LHb | AABR07054000.1 | intron excision ratio | chr3:127725722:127747858 | 0.14 | 1 | 0.05 | 2.9e-02 | -6.08 | 1.18e-09 | 0.05 | FALSE |
LHb | AABR07054000.1 | intron excision ratio | chr3:127725722:127779334 | 0.13 | 1 | 0.03 | 6.5e-02 | 6.08 | 1.18e-09 | 0.05 | FALSE |
Liver | Flrt3 | alternative TSS | ENSRNOT00000006454 | 0.03 | 2101 | 0.01 | 2.0e-02 | 6.61 | 3.75e-11 | 0.2 | FALSE |
Liver | Ndufaf5 | gene expression | ENSRNOG00000004784 | 0.17 | 21 | 0.1 | 1.1e-10 | 5.13 | 2.93e-07 | 0 | FALSE |
Liver | Flrt3 | isoform ratio | ENSRNOT00000006454 | 0.03 | 2101 | 0.01 | 6.6e-02 | 6.55 | 5.62e-11 | 0.18 | FALSE |
Liver | AABR07054000.1 | intron excision ratio | chr3:127747955:127748961 | 0.03 | 1836 | 0.01 | 1.4e-02 | -5.58 | 2.36e-08 | 0.38 | FALSE |
Liver | AABR07054000.1 | intron excision ratio | chr3:127747955:127749007 | 0.03 | 25 | 0.02 | 5.2e-03 | 6.71 | 1.96e-11 | 0.44 | FALSE |
NAcc | AABR07054000.1 | alternative polyA | ENSRNOT00000072928 | 0.08 | 1 | 0.03 | 1.7e-03 | -5.54 | 2.96e-08 | 0.03 | FALSE |
NAcc | AABR07054000.1 | alternative polyA | ENSRNOT00000110455 | 0.11 | 1836 | 0.01 | 2.5e-02 | 6.4 | 1.57e-10 | 0.15 | FALSE |
NAcc | Tasp1 | gene expression | ENSRNOG00000004493 | 0.05 | 1 | 0.04 | 6.8e-04 | 5.61 | 2.02e-08 | 0.04 | FALSE |
NAcc | Ndufaf5 | gene expression | ENSRNOG00000004784 | 0.06 | 1671 | 0.03 | 3.7e-03 | 6.52 | 7.05e-11 | 0.27 | FALSE |
NAcc | AABR07054000.1 | gene expression | ENSRNOG00000050784 | 0.1 | 5 | 0.09 | 1.9e-07 | -6.13 | 8.89e-10 | 0.36 | FALSE |
NAcc | AABR07054000.1 | isoform ratio | ENSRNOT00000072928 | 0.07 | 1836 | 0.03 | 5.6e-03 | -6.42 | 1.38e-10 | 0.35 | FALSE |
NAcc | AABR07054000.1 | isoform ratio | ENSRNOT00000117007 | 0.06 | 1836 | 0.05 | 2.4e-04 | 6.03 | 1.62e-09 | 0.46 | FALSE |
NAcc | Tasp1 | intron excision ratio | chr3:127385117:127399392 | 0.07 | 1 | 0.02 | 1.0e-02 | -5.61 | 2.02e-08 | 0.11 | FALSE |
NAcc | Ndufaf5 | mRNA stability | ENSRNOG00000004784 | 0.1 | 36 | 0.07 | 6.6e-06 | 6.01 | 1.82e-09 | 0.47 | FALSE |
OFC | AABR07054000.1 | alternative polyA | ENSRNOT00000072928 | 0.21 | 1 | 0.1 | 2.4e-03 | -5.88 | 4.02e-09 | 0.05 | FALSE |
OFC | Ism1 | gene expression | ENSRNOG00000063262 | 0.24 | 1 | 0.12 | 1.1e-03 | -5.63 | 1.81e-08 | 0.08 | FALSE |
OFC | Ndufaf5 | intron excision ratio | chr3:127508215:127509498 | 0.58 | 1669 | 0.23 | 4.6e-06 | 5.13 | 2.85e-07 | 0.01 | FALSE |
OFC | Ndufaf5 | intron excision ratio | chr3:127508256:127509498 | 0.61 | 1669 | 0.24 | 1.6e-06 | -5.21 | 1.92e-07 | 0.01 | FALSE |
OFC | Tasp1 | mRNA stability | ENSRNOG00000004493 | 0.17 | 1 | 0.11 | 1.2e-03 | -5.98 | 2.28e-09 | 0.06 | FALSE |
PL | AABR07054000.1 | alternative polyA | ENSRNOT00000072928 | 0.17 | 1 | 0.17 | 1.1e-12 | -6.15 | 7.72e-10 | 0.27 | FALSE |
PL | AABR07054000.1 | alternative polyA | ENSRNOT00000117007 | 0.08 | 13 | 0.08 | 5.7e-07 | 6.14 | 8.34e-10 | 0.63 | FALSE |
PL | Tasp1 | gene expression | ENSRNOG00000004493 | 0.04 | 8 | 0.02 | 1.0e-02 | -6.16 | 7.34e-10 | 0.38 | FALSE |
PL | Ndufaf5 | gene expression | ENSRNOG00000004784 | 0.16 | 24 | 0.08 | 5.9e-07 | 5.95 | 2.61e-09 | 0.08 | FALSE |
PL | AABR07054000.1 | gene expression | ENSRNOG00000050784 | 0.09 | 1 | 0.11 | 6.0e-09 | -5.94 | 2.82e-09 | 0.09 | FALSE |
PL | AABR07054000.1 | isoform ratio | ENSRNOT00000072928 | 0.21 | 1 | 0.15 | 2.5e-11 | -6.15 | 7.72e-10 | 0.27 | FALSE |
PL | AABR07054000.1 | isoform ratio | ENSRNOT00000117007 | 0.1 | 1 | 0.12 | 3.1e-09 | 6.18 | 6.49e-10 | 0.3 | FALSE |
PL | Tasp1 | intron excision ratio | chr3:127385117:127399392 | 0.04 | 1687 | 0.04 | 1.1e-03 | -5.87 | 4.44e-09 | 0.45 | FALSE |
PL | AABR07054000.1 | intron excision ratio | chr3:127725722:127747858 | 0.04 | 1 | 0.03 | 1.8e-03 | -5.95 | 2.75e-09 | 0.03 | FALSE |
PL | AABR07054000.1 | intron excision ratio | chr3:127725722:127779334 | 0.04 | 1 | 0.03 | 1.6e-03 | 5.95 | 2.75e-09 | 0.04 | FALSE |
PL | Tasp1 | mRNA stability | ENSRNOG00000004493 | 0.04 | 1687 | 0.04 | 5.9e-04 | -5.78 | 7.28e-09 | 0.48 | FALSE |
PL | Ndufaf5 | mRNA stability | ENSRNOG00000004784 | 0.18 | 50 | 0.13 | 4.7e-10 | 6.03 | 1.59e-09 | 0.16 | FALSE |