chr3:126,160,536-128,707,024

Trait: Body weight

Best TWAS P=5.52e-12 · Best GWAS P=2.20e-12 conditioned to 1.00e+00

Associated models

Tissue Gene RNA modality RNA phenotype h2 # weights Model R2 Model R2 P TWAS Z TWAS P Coloc P Joint
Adipose AABR07054000.1 alternative polyA ENSRNOT00000072928 0.26 1836 0.16 2.6e-17 -6.15 8.00e-10 0.54 FALSE
Adipose AABR07054000.1 alternative polyA ENSRNOT00000110455 0.08 22 0.06 5.7e-07 5.62 1.89e-08 0.56 FALSE
Adipose AABR07054000.1 alternative polyA ENSRNOT00000117007 0.07 1 0.04 1.2e-05 5.8 6.80e-09 0.03 FALSE
Adipose AABR07054000.1 gene expression ENSRNOG00000050784 0.42 1 0.3 4.0e-34 5.99 2.10e-09 0.12 TRUE
Adipose AABR07054000.1 isoform ratio ENSRNOT00000072928 0.28 59 0.19 8.1e-21 -5.98 2.19e-09 0.4 FALSE
Adipose AABR07054000.1 isoform ratio ENSRNOT00000110455 0.09 1836 0.06 1.8e-07 6.36 2.03e-10 0.55 FALSE
Adipose AABR07054000.1 isoform ratio ENSRNOT00000117007 0.15 471 0.09 1.3e-10 6 2.03e-09 0.33 FALSE
Adipose Esf1 mRNA stability ENSRNOG00000004777 0.17 1671 0.07 2.9e-08 5.87 4.24e-09 0 FALSE
Adipose Ndufaf5 mRNA stability ENSRNOG00000004784 0.04 54 0.01 1.5e-02 5.85 5.06e-09 0.48 FALSE
BLA AABR07054000.1 alternative polyA ENSRNOT00000072928 0.14 1836 0.09 1.9e-05 -6.71 1.89e-11 0.54 FALSE
BLA AABR07054000.1 alternative polyA ENSRNOT00000117007 0.12 1 0.08 7.2e-05 5.94 2.82e-09 0.04 FALSE
BLA Flrt3 gene expression ENSRNOG00000004874 0.06 1 0.04 5.4e-03 -5.77 7.91e-09 0.04 FALSE
BLA AABR07054000.1 gene expression ENSRNOG00000050784 0.09 49 0.03 1.5e-02 -6.89 5.52e-12 0.24 TRUE
BLA AABR07054000.1 isoform ratio ENSRNOT00000072928 0.15 1836 0.15 2.4e-08 -6.59 4.44e-11 0.43 FALSE
BLA AABR07054000.1 isoform ratio ENSRNOT00000117007 0.11 1 0.07 1.1e-04 5.94 2.82e-09 0.04 FALSE
BLA Ndufaf5 intron excision ratio chr3:127508215:127509498 0.8 162 0.44 6.0e-26 5.55 2.80e-08 0 FALSE
BLA Ndufaf5 intron excision ratio chr3:127508256:127509498 0.79 169 0.44 7.1e-26 -5.49 3.98e-08 0 FALSE
BLA AABR07054000.1 intron excision ratio chr3:127725722:127779334 0.06 1 0.03 1.6e-02 6.47 1.00e-10 0.04 FALSE
BLA Tasp1 mRNA stability ENSRNOG00000004493 0.11 5 0.08 2.9e-05 -5.63 1.78e-08 0.5 FALSE
Brain AABR07054000.1 alternative polyA ENSRNOT00000072928 0.03 1 0.02 4.5e-03 -5.75 9.09e-09 0.03 FALSE
Brain Sptlc3 gene expression ENSRNOG00000004443 0.06 5 0.05 1.0e-05 -5.24 1.61e-07 0.39 TRUE
Brain AABR07054000.1 gene expression ENSRNOG00000050784 0.04 1 0.05 2.2e-05 -6.47 9.63e-11 0.21 FALSE
Brain Ism1 gene expression ENSRNOG00000063262 0.05 32 0.04 8.7e-05 -5.98 2.19e-09 0.52 FALSE
Brain AABR07054000.1 isoform ratio ENSRNOT00000072928 0.04 1 0.04 6.8e-05 -5.81 6.15e-09 0.04 FALSE
Brain AABR07054000.1 isoform ratio ENSRNOT00000117007 0.04 1 0.02 3.2e-03 5.54 3.07e-08 0.03 FALSE
Brain Tasp1 mRNA stability ENSRNOG00000004493 0.13 26 0.14 7.5e-13 -5.13 2.91e-07 0.29 FALSE
Eye Ism1 gene expression ENSRNOG00000063262 0.59 1704 0.07 3.4e-02 5.93 3.08e-09 0.23 FALSE
IL AABR07054000.1 gene expression ENSRNOG00000050784 0.21 1 0.04 3.1e-02 -6.35 2.16e-10 0.05 FALSE
IL AABR07054000.1 isoform ratio ENSRNOT00000117007 0.18 1 0.11 1.2e-03 5.95 2.69e-09 0.05 FALSE
IL Tasp1 intron excision ratio chr3:127355890:127385049 0.25 9 0.06 1.6e-02 -5.55 2.86e-08 0.07 TRUE
IL Tasp1 mRNA stability ENSRNOG00000004493 0.14 1685 0.1 2.2e-03 -6.1 1.05e-09 0.39 FALSE
IL Ndufaf5 mRNA stability ENSRNOG00000004784 0.19 1 0.08 6.8e-03 6.16 7.09e-10 0.06 FALSE
LHb AABR07054000.1 gene expression ENSRNOG00000050784 0.23 97 0.17 9.3e-05 -5.94 2.93e-09 0.64 FALSE
LHb AABR07054000.1 intron excision ratio chr3:127725722:127747858 0.14 1 0.05 2.9e-02 -6.08 1.18e-09 0.05 FALSE
LHb AABR07054000.1 intron excision ratio chr3:127725722:127779334 0.13 1 0.03 6.5e-02 6.08 1.18e-09 0.05 FALSE
Liver Flrt3 alternative TSS ENSRNOT00000006454 0.03 2101 0.01 2.0e-02 6.61 3.75e-11 0.2 FALSE
Liver Ndufaf5 gene expression ENSRNOG00000004784 0.17 21 0.1 1.1e-10 5.13 2.93e-07 0 FALSE
Liver Flrt3 isoform ratio ENSRNOT00000006454 0.03 2101 0.01 6.6e-02 6.55 5.62e-11 0.18 FALSE
Liver AABR07054000.1 intron excision ratio chr3:127747955:127748961 0.03 1836 0.01 1.4e-02 -5.58 2.36e-08 0.38 FALSE
Liver AABR07054000.1 intron excision ratio chr3:127747955:127749007 0.03 25 0.02 5.2e-03 6.71 1.96e-11 0.44 FALSE
NAcc AABR07054000.1 alternative polyA ENSRNOT00000072928 0.08 1 0.03 1.7e-03 -5.54 2.96e-08 0.03 FALSE
NAcc AABR07054000.1 alternative polyA ENSRNOT00000110455 0.11 1836 0.01 2.5e-02 6.4 1.57e-10 0.15 FALSE
NAcc Tasp1 gene expression ENSRNOG00000004493 0.05 1 0.04 6.8e-04 5.61 2.02e-08 0.04 FALSE
NAcc Ndufaf5 gene expression ENSRNOG00000004784 0.06 1671 0.03 3.7e-03 6.52 7.05e-11 0.27 FALSE
NAcc AABR07054000.1 gene expression ENSRNOG00000050784 0.1 5 0.09 1.9e-07 -6.13 8.89e-10 0.36 FALSE
NAcc AABR07054000.1 isoform ratio ENSRNOT00000072928 0.07 1836 0.03 5.6e-03 -6.42 1.38e-10 0.35 FALSE
NAcc AABR07054000.1 isoform ratio ENSRNOT00000117007 0.06 1836 0.05 2.4e-04 6.03 1.62e-09 0.46 FALSE
NAcc Tasp1 intron excision ratio chr3:127385117:127399392 0.07 1 0.02 1.0e-02 -5.61 2.02e-08 0.11 FALSE
NAcc Ndufaf5 mRNA stability ENSRNOG00000004784 0.1 36 0.07 6.6e-06 6.01 1.82e-09 0.47 FALSE
OFC AABR07054000.1 alternative polyA ENSRNOT00000072928 0.21 1 0.1 2.4e-03 -5.88 4.02e-09 0.05 FALSE
OFC Ism1 gene expression ENSRNOG00000063262 0.24 1 0.12 1.1e-03 -5.63 1.81e-08 0.08 FALSE
OFC Ndufaf5 intron excision ratio chr3:127508215:127509498 0.58 1669 0.23 4.6e-06 5.13 2.85e-07 0.01 FALSE
OFC Ndufaf5 intron excision ratio chr3:127508256:127509498 0.61 1669 0.24 1.6e-06 -5.21 1.92e-07 0.01 FALSE
OFC Tasp1 mRNA stability ENSRNOG00000004493 0.17 1 0.11 1.2e-03 -5.98 2.28e-09 0.06 FALSE
PL AABR07054000.1 alternative polyA ENSRNOT00000072928 0.17 1 0.17 1.1e-12 -6.15 7.72e-10 0.27 FALSE
PL AABR07054000.1 alternative polyA ENSRNOT00000117007 0.08 13 0.08 5.7e-07 6.14 8.34e-10 0.63 FALSE
PL Tasp1 gene expression ENSRNOG00000004493 0.04 8 0.02 1.0e-02 -6.16 7.34e-10 0.38 FALSE
PL Ndufaf5 gene expression ENSRNOG00000004784 0.16 24 0.08 5.9e-07 5.95 2.61e-09 0.08 FALSE
PL AABR07054000.1 gene expression ENSRNOG00000050784 0.09 1 0.11 6.0e-09 -5.94 2.82e-09 0.09 FALSE
PL AABR07054000.1 isoform ratio ENSRNOT00000072928 0.21 1 0.15 2.5e-11 -6.15 7.72e-10 0.27 FALSE
PL AABR07054000.1 isoform ratio ENSRNOT00000117007 0.1 1 0.12 3.1e-09 6.18 6.49e-10 0.3 FALSE
PL Tasp1 intron excision ratio chr3:127385117:127399392 0.04 1687 0.04 1.1e-03 -5.87 4.44e-09 0.45 FALSE
PL AABR07054000.1 intron excision ratio chr3:127725722:127747858 0.04 1 0.03 1.8e-03 -5.95 2.75e-09 0.03 FALSE
PL AABR07054000.1 intron excision ratio chr3:127725722:127779334 0.04 1 0.03 1.6e-03 5.95 2.75e-09 0.04 FALSE
PL Tasp1 mRNA stability ENSRNOG00000004493 0.04 1687 0.04 5.9e-04 -5.78 7.28e-09 0.48 FALSE
PL Ndufaf5 mRNA stability ENSRNOG00000004784 0.18 50 0.13 4.7e-10 6.03 1.59e-09 0.16 FALSE