Hub : Traits

Heart weight

Tags: Physiology · Weight

Project: dissection

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	5	160021937	161418138	1	1	1.32e-07	2.75e-07	2.41e-54	Eno1
2	9	65372539	66767704	1	1	2.55e-07	2.83e-01	7.68e-01	Ccnyl1

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	2.03	1	0	0	0	1e+00	Ccnyl1
BMI without tail	4.42	1	0	0	0	1e+00	Ccnyl1
Length with tail	2.27	1	0	0	0	1e+00	Ccnyl1
Length without tail	2.71	1	0	0	0	1e+00	Ccnyl1
Liver weight, left	4.67	1	0	0	0	1e+00	Eno1
Liver weight, right	3.31	2	0	0	0	1e+00	Eno1 Ccnyl1
Extensor digitorum longus weight	2.54	1	0	0	0	1e+00	Ccnyl1
Soleus weight	6.32	1	0	0	0	1e+00	Ccnyl1
Tibialis anterior weight	2.95	1	0	0	0	1e+00	Ccnyl1
Indifference point AUC	15.53	1	0	0	0	1e+00	Ccnyl1
Indifference point function ln k	6.95	1	0	0	0	1e+00	Ccnyl1
Indifference point function log k	6.95	1	0	0	0	1e+00	Ccnyl1
Delay discounting total patch changes 12 sec	6.64	1	0	0	0	1e+00	Ccnyl1
Delay discounting water rate 18 sec	6.22	1	0	0	0	1e+00	Ccnyl1
Delay discounting water rate 24 sec	12.83	1	0	0	0	1e+00	Ccnyl1
Locomotor testing distance	6.3	2	0	0	0	1e+00	Eno1 Ccnyl1
Locomotor testing rearing	4.95	1	0	0	0	1e+00	Ccnyl1
Reaction time mean minus median	4.97	1	0	0	0	1e+00	Ccnyl1
Cocaine response before conditioning	7.64	1	0	0	0	1e+00	Ccnyl1
Conditioned locomotion	11.04	1	0	0	0	1e+00	Ccnyl1
Intermitt. access escalation Index	28.71	1	0	0	0	1e+00	Ccnyl1
Intermittent access total locomotion	7.11	1	0	0	0	1e+00	Ccnyl1
Progressive ratio test 1 active lever presses	10.01	1	0	0	0	1e+00	Ccnyl1
Progressive ratio test 1 breakpoint	9.84	1	0	0	0	1e+00	Ccnyl1
Compulsive drug intake	6.37	1	0	0	0	1e+00	Eno1
Number of responses in last shaping day	8.16	1	0	0	0	1e+00	Ccnyl1
Context. condit. distance diff. score	5.65	1	0	0	0	1e+00	Ccnyl1
Locomotion velocity, session 2	5.71	1	0	0	0	1e+00	Ccnyl1
Condit. Reinf. inactive responses	6.27	2	0	0	0	1e+00	Eno1 Ccnyl1
Condit. Reinf. lever presses	5.93	1	0	0	0	1e+00	Ccnyl1
Time in novel zone, hab. session 2	6.08	1	0	0	0	1e+00	Ccnyl1
Bone: cortical apparent density	6.47	1	0	0	0	1e+00	Ccnyl1
Bone: cortical porosity	9.95	1	0	0	0	1e+00	Ccnyl1
Bone: cortical porosity	9.53	1	0	0	0	1e+00	Ccnyl1
Bone: cortical tissue density	6.15	1	0	0	0	1e+00	Ccnyl1
Bone: tissue strength	6.89	1	0	0	0	1e+00	Ccnyl1
Breakpoint value in progressive ratio session	4.73	1	0	0	0	1e+00	Ccnyl1
Distance traveled before self-admin	5.88	1	0	0	0	1e+00	Eno1
Sum of active levers in priming session hrs 5-6	5.98	1	0	0	0	1e+00	Ccnyl1
Time to tail flick, vehicle, after self-admin	6.78	1	0	0	0	1e+00	Ccnyl1
Time to tail flick, test, before self-admin	11.45	1	0	0	0	1e+00	Ccnyl1
Delta time to tail flick, test, before/after SA	18.92	1	0	0	0	1e+00	Ccnyl1
Ambulatory time before self-admin	5.79	1	0	0	0	1e+00	Ccnyl1
Ambulatory time after self-admin	7.6	1	0	0	0	1e+00	Ccnyl1
Delay disc. indifference point, 24s delay	6.02	1	0	0	0	1e+00	Eno1
Delay disc. indifference point, 4s delay	5.4	1	0	0	0	1e+00	Eno1
Delay discount exponential model param	5.25	1	0	0	0	1e+00	Eno1
Delay discount hyperbolic model param	4.89	1	0	0	0	1e+00	Eno1
Fecal boli incidents, locomotor time 1	4.97	1	0	0	0	1e+00	Eno1
Rest time, locomotor task time 2	4.83	1	0	0	0	1e+00	Eno1
Weight adjusted by age	5.73	1	0	0	0	1e+00	Ccnyl1
Locomotion in novel chamber	13.42	1	0	0	0	1e+00	Ccnyl1
Food seeking constrained by brief footshock	4.57	1	0	0	0	1e+00	Ccnyl1
Run reversals in cocaine runway, females	5.27	1	0	0	0	1e+00	Ccnyl1
K content in liver	11.9	1	0	0	0	1e+00	Ccnyl1
Na content in liver	17.58	1	0	0	0	1e+00	Ccnyl1

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.42
Adipose	alternative TSS	0	0	1.36
Adipose	gene expression	0	0	1.39
Adipose	isoform ratio	0	0	1.36
Adipose	intron excision ratio	0	0	1.4
Adipose	mRNA stability	0	0	1.44
BLA	alternative polyA	0	0	1.4
BLA	alternative TSS	0	0	1.28
BLA	gene expression	0	0	1.44
BLA	isoform ratio	0	0	1.44
BLA	intron excision ratio	0	0	1.49
BLA	mRNA stability	0	0	1.42
Brain	alternative polyA	0	0	1.4
Brain	alternative TSS	0	0	1.5
Brain	gene expression	0	0	1.42
Brain	isoform ratio	0	0	1.43
Brain	intron excision ratio	0	0	1.42
Brain	mRNA stability	0	0	1.4
Eye	alternative polyA	0	0	1.28
Eye	alternative TSS	0	0	1.25
Eye	gene expression	0	0	1.37
Eye	isoform ratio	1	0.3	1.62
Eye	intron excision ratio	0	0	1.63
Eye	mRNA stability	0	0	1.38
IL	alternative polyA	0	0	1.42
IL	alternative TSS	0	0	1.55
IL	gene expression	0	0	1.43
IL	isoform ratio	0	0	1.45
IL	intron excision ratio	0	0	1.55
IL	mRNA stability	0	0	1.34
LHb	alternative polyA	0	0	1.31
LHb	alternative TSS	0	0	1.58
LHb	gene expression	0	0	1.43
LHb	isoform ratio	0	0	1.33
LHb	intron excision ratio	0	0	1.58
LHb	mRNA stability	0	0	1.4
Liver	alternative polyA	0	0	1.4
Liver	alternative TSS	0	0	1.47
Liver	gene expression	0	0	1.41
Liver	isoform ratio	0	0	1.48
Liver	intron excision ratio	0	0	1.47
Liver	mRNA stability	0	0	1.41
NAcc	alternative polyA	0	0	1.35
NAcc	alternative TSS	0	0	1.41
NAcc	gene expression	1	0	1.46
NAcc	isoform ratio	0	0	1.48
NAcc	intron excision ratio	0	0	1.49
NAcc	mRNA stability	0	0	1.46
OFC	alternative polyA	0	0	1.38
OFC	alternative TSS	0	0	1.67
OFC	gene expression	0	0	1.43
OFC	isoform ratio	0	0	1.56
OFC	intron excision ratio	0	0	1.5
OFC	mRNA stability	0	0	1.36
PL	alternative polyA	0	0	1.41
PL	alternative TSS	0	0	1.53
PL	gene expression	0	0	1.48
PL	isoform ratio	0	0	1.43
PL	intron excision ratio	0	0	1.45
PL	mRNA stability	0	0	1.41