Hub : Traits

Heart weight

Tags: Physiology · Weight

Project: dissection

2 significantly associated models · 2 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 5 160021937 161418138 1 1 1.3e-07 2.8e-07 2.4e-54 -812 Eno1
2 9 65372539 66767704 1 1 2.5e-07 2.8e-01 7.7e-01 92 Ccnyl1

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI with tail 2.0 1 0 0 0 1 Ccnyl1
BMI without tail 4.4 1 0 0 0 1 Ccnyl1
Length with tail 2.3 1 0 0 0 1 Ccnyl1
Length without tail 2.7 1 0 0 0 1 Ccnyl1
Liver weight, left 4.7 1 0 0 0 1 Eno1
Liver weight, right 3.3 2 0 0 0 1 Eno1 Ccnyl1
Extensor digitorum longus weight 2.5 1 0 0 0 1 Ccnyl1
Soleus weight 6.3 1 0 0 0 1 Ccnyl1
Tibialis anterior weight 3.0 1 0 0 0 1 Ccnyl1
Indifference point AUC 15.5 1 0 0 0 1 Ccnyl1
Indifference point function ln k 7.0 1 0 0 0 1 Ccnyl1
Indifference point function log k 7.0 1 0 0 0 1 Ccnyl1
Delay discounting total patch changes 12 sec 6.6 1 0 0 0 1 Ccnyl1
Delay discounting water rate 18 sec 6.2 1 0 0 0 1 Ccnyl1
Delay discounting water rate 24 sec 12.8 1 0 0 0 1 Ccnyl1
Locomotor testing distance 6.3 2 0 0 0 1 Eno1 Ccnyl1
Locomotor testing rearing 5.0 1 0 0 0 1 Ccnyl1
Reaction time mean minus median 5.0 1 0 0 0 1 Ccnyl1
Cocaine response before conditioning 7.6 1 0 0 0 1 Ccnyl1
Conditioned locomotion 11.0 1 0 0 0 1 Ccnyl1
Intermitt. access escalation Index 28.7 1 0 0 0 1 Ccnyl1
Intermittent access total locomotion 7.1 1 0 0 0 1 Ccnyl1
Progressive ratio test 1 active lever presses 10.0 1 0 0 0 1 Ccnyl1
Progressive ratio test 1 breakpoint 9.8 1 0 0 0 1 Ccnyl1
Compulsive drug intake 6.4 1 0 0 0 1 Eno1
Number of responses in last shaping day 8.2 1 0 0 0 1 Ccnyl1
Context. condit. distance diff. score 5.7 1 0 0 0 1 Ccnyl1
Locomotion velocity, session 2 5.7 1 0 0 0 1 Ccnyl1
Condit. Reinf. inactive responses 6.3 2 0 0 0 1 Eno1 Ccnyl1
Condit. Reinf. lever presses 5.9 1 0 0 0 1 Ccnyl1
Time in novel zone, hab. session 2 6.1 1 0 0 0 1 Ccnyl1
Bone: cortical apparent density 6.5 1 0 0 0 1 Ccnyl1
Bone: cortical porosity 9.9 1 0 0 0 1 Ccnyl1
Bone: cortical porosity 9.5 1 0 0 0 1 Ccnyl1
Bone: cortical tissue density 6.2 1 0 0 0 1 Ccnyl1
Bone: tissue strength 6.9 1 0 0 0 1 Ccnyl1
Breakpoint value in progressive ratio session 4.7 1 0 0 0 1 Ccnyl1
Distance traveled before self-admin 5.9 1 0 0 0 1 Eno1
Sum of active levers in priming session hrs 5-6 6.0 1 0 0 0 1 Ccnyl1
Time to tail flick, vehicle, after self-admin 6.8 1 0 0 0 1 Ccnyl1
Time to tail flick, test, before self-admin 11.4 1 0 0 0 1 Ccnyl1
Delta time to tail flick, test, before/after SA 18.9 1 0 0 0 1 Ccnyl1
Ambulatory time before self-admin 5.8 1 0 0 0 1 Ccnyl1
Ambulatory time after self-admin 7.6 1 0 0 0 1 Ccnyl1
Delay disc. indifference point, 24s delay 6.0 1 0 0 0 1 Eno1
Delay disc. indifference point, 4s delay 5.4 1 0 0 0 1 Eno1
Delay discount exponential model param 5.2 1 0 0 0 1 Eno1
Delay discount hyperbolic model param 4.9 1 0 0 0 1 Eno1
Fecal boli incidents, locomotor time 1 5.0 1 0 0 0 1 Eno1
Rest time, locomotor task time 2 4.8 1 0 0 0 1 Eno1
Weight adjusted by age 5.7 1 0 0 0 1 Ccnyl1
Locomotion in novel chamber 13.4 1 0 0 0 1 Ccnyl1
Food seeking constrained by brief footshock 4.6 1 0 0 0 1 Ccnyl1
Run reversals in cocaine runway, females 5.3 1 0 0 0 1 Ccnyl1
K content in liver 11.9 1 0 0 0 1 Ccnyl1
Na content in liver 17.6 1 0 0 0 1 Ccnyl1

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.4
Adipose alternative TSS 0 0.000 1.4
Adipose gene expression 0 0.000 1.4
Adipose isoform ratio 0 0.000 1.4
Adipose intron excision ratio 0 0.000 1.4
Adipose mRNA stability 0 0.000 1.4
BLA alternative polyA 0 0.000 1.4
BLA alternative TSS 0 0.000 1.3
BLA gene expression 0 0.000 1.4
BLA isoform ratio 0 0.000 1.4
BLA intron excision ratio 0 0.000 1.5
BLA mRNA stability 0 0.000 1.4
Brain alternative polyA 0 0.000 1.4
Brain alternative TSS 0 0.000 1.5
Brain gene expression 0 0.000 1.4
Brain isoform ratio 0 0.000 1.4
Brain intron excision ratio 0 0.000 1.4
Brain mRNA stability 0 0.000 1.4
Eye alternative polyA 0 0.000 1.3
Eye alternative TSS 0 0.000 1.2
Eye gene expression 0 0.000 1.4
Eye isoform ratio 1 0.282 1.6
Eye intron excision ratio 0 0.000 1.6
Eye mRNA stability 0 0.000 1.4
IL alternative polyA 0 0.000 1.4
IL alternative TSS 0 0.000 1.5
IL gene expression 0 0.000 1.4
IL isoform ratio 0 0.000 1.4
IL intron excision ratio 0 0.000 1.5
IL mRNA stability 0 0.000 1.3
LHb alternative polyA 0 0.000 1.3
LHb alternative TSS 0 0.000 1.6
LHb gene expression 0 0.000 1.4
LHb isoform ratio 0 0.000 1.3
LHb intron excision ratio 0 0.000 1.6
LHb mRNA stability 0 0.000 1.4
Liver alternative polyA 0 0.000 1.4
Liver alternative TSS 0 0.000 1.5
Liver gene expression 0 0.000 1.4
Liver isoform ratio 0 0.000 1.5
Liver intron excision ratio 0 0.000 1.5
Liver mRNA stability 0 0.000 1.4
NAcc alternative polyA 0 0.000 1.3
NAcc alternative TSS 0 0.000 1.4
NAcc gene expression 1 0.016 1.5
NAcc isoform ratio 0 0.000 1.5
NAcc intron excision ratio 0 0.000 1.5
NAcc mRNA stability 0 0.000 1.5
OFC alternative polyA 0 0.000 1.4
OFC alternative TSS 0 0.000 1.7
OFC gene expression 0 0.000 1.4
OFC isoform ratio 0 0.000 1.6
OFC intron excision ratio 0 0.000 1.5
OFC mRNA stability 0 0.000 1.4
PL alternative polyA 0 0.000 1.4
PL alternative TSS 0 0.000 1.5
PL gene expression 0 0.000 1.5
PL isoform ratio 0 0.000 1.4
PL intron excision ratio 0 0.000 1.4
PL mRNA stability 0 0.000 1.4

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.