# | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | gene expression | ENSRNOG00000027157 | 0.0450 | 0.0270 | 2.9e-04 | -0.001 | 0.014 | 0.012 | 0.001 | 5.3e-01 | 8.7e-03 | 1.5e-02 | 2.2e-01 |
2 | BLA | gene expression | ENSRNOG00000027157 | 0.2475 | 0.0995 | 1.2e-09 | 0.140 | 0.165 | 0.131 | 0.143 | 6.6e-08 | 3.5e-09 | 1.6e-07 | 4.3e-08 |
3 | Brain | alternative TSS | ENSRNOT00000037482 | 0.0672 | 0.0458 | 1.3e-04 | 0.037 | 0.014 | 0.008 | 0.023 | 2.2e-04 | 1.7e-02 | 5.1e-02 | 2.9e-03 |
4 | Brain | alternative TSS | ENSRNOT00000113254 | 0.0669 | 0.0458 | 1.3e-04 | 0.051 | 0.013 | 0.008 | 0.023 | 1.5e-05 | 1.9e-02 | 5.4e-02 | 2.8e-03 |
5 | Brain | gene expression | ENSRNOG00000027157 | 0.3000 | 0.1000 | 0.0e+00 | 0.243 | 0.239 | 0.240 | 0.239 | 2.1e-22 | 5.9e-22 | 4.2e-22 | 5.5e-22 |
6 | Brain | intron excision ratio | chr20:3745939:3746623 | 0.1595 | 0.0837 | 7.1e-10 | 0.044 | 0.050 | 0.054 | 0.053 | 5.9e-05 | 1.8e-05 | 9.1e-06 | 1.2e-05 |
7 | Brain | intron excision ratio | chr20:3745939:3747796 | 0.0854 | 0.0469 | 7.9e-06 | 0.026 | 0.032 | 0.023 | 0.020 | 1.7e-03 | 5.7e-04 | 3.1e-03 | 5.5e-03 |
8 | Brain | intron excision ratio | chr20:3746725:3747796 | 0.0362 | 0.0253 | 9.0e-03 | 0.005 | 0.010 | 0.003 | 0.005 | 9.5e-02 | 3.6e-02 | 1.4e-01 | 1.0e-01 |
9 | Brain | intron excision ratio | chr20:3747963:3749733 | 0.0561 | 0.0360 | 8.6e-04 | -0.001 | 0.000 | -0.001 | -0.001 | 4.3e-01 | 3.5e-01 | 4.2e-01 | 4.1e-01 |
10 | Brain | mRNA stability | ENSRNOG00000027157 | 0.1796 | 0.0895 | 6.1e-16 | 0.162 | 0.167 | 0.155 | 0.167 | 7.2e-15 | 2.7e-15 | 3.3e-14 | 2.9e-15 |
11 | IL | gene expression | ENSRNOG00000027157 | 0.6930 | 0.1470 | 6.3e-11 | 0.336 | 0.368 | 0.343 | 0.332 | 6.8e-09 | 9.2e-10 | 4.6e-09 | 8.7e-09 |
12 | LHb | gene expression | ENSRNOG00000027157 | 0.3673 | 0.1405 | 1.1e-06 | 0.177 | 0.276 | 0.273 | 0.242 | 5.4e-05 | 2.9e-07 | 3.4e-07 | 1.8e-06 |
13 | NAcc | gene expression | ENSRNOG00000027157 | 0.1700 | 0.0890 | 2.8e-06 | 0.025 | 0.060 | 0.046 | 0.053 | 5.4e-03 | 2.9e-05 | 2.2e-04 | 8.7e-05 |
14 | OFC | gene expression | ENSRNOG00000027157 | 0.4359 | 0.1434 | 1.4e-09 | 0.359 | 0.407 | 0.376 | 0.407 | 2.1e-09 | 9.0e-11 | 6.9e-10 | 9.0e-11 |
15 | PL | gene expression | ENSRNOG00000027157 | 0.6964 | 0.1430 | 0.0e+00 | 0.207 | 0.214 | 0.205 | 0.203 | 1.1e-15 | 3.3e-16 | 1.5e-15 | 2.3e-15 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Locomotion distance, session 7 | 6.7 | 8.6 | 11.5 | 2.4 | 0.8 | -3.3 | 3.3 | -1.8 | 3.2 | -3.4 | 3.4 | -3.4 | -2.8 | -3.2 | 3.0 | 2.5 | -3.1 | -3.1 |
Locomotion velocity, session 7 | 5.8 | 6.4 | 10.1 | 2.3 | 0.7 | -2.7 | 2.7 | -1.2 | 2.8 | -3.0 | 2.9 | -3.0 | -2.4 | -2.8 | 3.2 | 2.3 | -2.5 | -2.2 |
Cocaine response before conditioning | 5.3 | 6.5 | 14.9 | -3.2 | -1.9 | 2.5 | -2.5 | -0.3 | -2.3 | 2.8 | -2.6 | 2.7 | 1.8 | 2.6 | -3.9 | -3.1 | 2.3 | 2.0 |
Weight adjusted by age | 5.0 | 5.6 | 8.5 | -2.0 | -0.8 | 2.6 | -2.6 | 1.5 | -2.3 | 2.6 | -2.7 | 2.6 | 2.2 | 2.9 | -2.2 | -1.7 | 2.9 | 2.9 |
Bone: marrow area | 4.6 | 10.0 | 18.4 | -4.3 | -3.3 | 3.1 | -3.1 | 0.0 | -2.6 | 3.1 | -3.1 | 3.1 | 1.6 | 3.1 | -3.8 | -4.2 | 3.5 | 3.1 |
Bone: endosteal estimation | 4.3 | 9.3 | 18.1 | -4.3 | -3.3 | 2.9 | -2.9 | -0.1 | -2.5 | 2.9 | -2.9 | 2.9 | 1.4 | 3.0 | -3.7 | -4.2 | 3.3 | 3.0 |
Locomotion distance, session 8 | 4.1 | 6.2 | 10.9 | 1.0 | -1.1 | -2.6 | 2.6 | -2.0 | 2.9 | -3.1 | 3.0 | -3.1 | -3.3 | -2.9 | 2.9 | 0.9 | -2.0 | -1.7 |
Diff in mean of infusions in LGA sessions | 4.1 | 4.6 | 7.6 | 1.6 | 0.2 | -2.8 | 2.8 | -1.0 | 2.5 | -2.4 | 2.4 | -2.4 | -2.2 | -2.5 | 2.4 | 1.3 | -2.1 | -1.9 |
Bone: trabecular spacing | 3.9 | 5.0 | 7.2 | -2.6 | -1.7 | 2.5 | -2.5 | 0.4 | -2.1 | 2.4 | -2.3 | 2.3 | 1.5 | 2.3 | -2.7 | -2.5 | 2.4 | 2.3 |
Body weight | 3.8 | 16.2 | 26.2 | -2.3 | -0.1 | 4.2 | -4.2 | 3.9 | -4.4 | 4.6 | -4.7 | 4.6 | 4.3 | 4.7 | -2.6 | -2.2 | 4.8 | 5.1 |
Bone: trabecular number | 3.7 | 5.7 | 9.8 | 3.1 | 2.2 | -2.5 | 2.5 | 0.1 | 2.1 | -2.4 | 2.4 | -2.4 | -1.3 | -2.4 | 3.1 | 3.0 | -2.4 | -2.2 |
Progressive ratio | 3.6 | 4.2 | 6.9 | -0.5 | 1.0 | 2.0 | -2.0 | 2.2 | -2.5 | 2.5 | -2.5 | 2.6 | 2.6 | 2.1 | -1.5 | -0.9 | 2.0 | 2.2 |
Tail length | 3.5 | 10.5 | 23.7 | -4.8 | -3.6 | 2.7 | -2.7 | -1.2 | -2.3 | 3.1 | -3.0 | 3.1 | 1.4 | 3.1 | -4.9 | -4.7 | 3.0 | 2.5 |
Pavlov. Cond. lever latency | 3.4 | 4.4 | 9.7 | 0.7 | 2.3 | 2.1 | -2.1 | 3.1 | -2.5 | 2.3 | -2.2 | 2.3 | 3.0 | 2.0 | -0.5 | 0.6 | 1.6 | 2.0 |
Pavlov. Cond. latency score | 3.3 | 4.2 | 11.3 | -1.1 | -2.5 | -1.9 | 1.9 | -3.4 | 2.3 | -2.0 | 2.0 | -2.0 | -2.9 | -1.9 | -0.0 | -1.1 | -1.6 | -2.0 |
Context. condit. distance diff. score | 3.2 | 3.9 | 8.0 | 0.0 | -1.7 | -2.0 | 2.0 | -2.2 | 2.3 | -2.4 | 2.3 | -2.4 | -2.8 | -2.2 | 1.7 | 0.1 | -1.5 | -1.5 |
Pavlov. Cond. index score | 3.1 | 3.9 | 10.7 | -1.1 | -2.4 | -1.8 | 1.8 | -3.3 | 2.2 | -1.9 | 2.0 | -2.0 | -2.8 | -1.9 | -0.0 | -1.1 | -1.5 | -1.9 |
Cu content in liver | 3.1 | 3.8 | 5.9 | 2.4 | 1.8 | -2.0 | 2.0 | -0.7 | 1.7 | -1.9 | 2.0 | -1.9 | -1.1 | -2.0 | 2.0 | 2.4 | -2.4 | -2.1 |
BMI without tail | 3.0 | 6.3 | 10.8 | -2.3 | -0.6 | 2.7 | -2.7 | 0.7 | -2.7 | 3.0 | -2.9 | 3.0 | 2.4 | 2.8 | -3.3 | -2.3 | 2.4 | 2.2 |
Pavlov. Cond. lever-magazine prob. diff. | 3.0 | 3.8 | 10.3 | -1.0 | -2.3 | -1.8 | 1.8 | -3.2 | 2.3 | -1.9 | 1.9 | -1.9 | -2.7 | -1.8 | -0.0 | -1.0 | -1.5 | -1.9 |
Condit. Reinf. lever presses | 2.9 | 3.9 | 7.4 | 0.4 | -1.3 | -2.2 | 2.2 | -1.9 | 2.4 | -2.4 | 2.3 | -2.4 | -2.7 | -2.3 | 1.9 | 0.3 | -1.6 | -1.5 |
Bone: periosteal estimation | 2.9 | 5.9 | 9.6 | -3.0 | -2.1 | 2.5 | -2.5 | 0.3 | -2.3 | 2.5 | -2.5 | 2.5 | 1.5 | 2.4 | -2.8 | -3.1 | 2.7 | 2.6 |
Saline control response | 2.8 | 3.7 | 7.8 | 0.2 | 1.8 | 1.9 | -1.9 | 2.4 | -2.3 | 2.3 | -2.2 | 2.3 | 2.8 | 2.1 | -1.3 | 0.2 | 1.5 | 1.4 |
Time in novel zone, hab. session 1 | 2.8 | 2.7 | 5.2 | -2.2 | -1.8 | 1.5 | -1.5 | 0.1 | -1.4 | 1.6 | -1.6 | 1.6 | 0.8 | 1.6 | -1.7 | -2.3 | 1.9 | 1.9 |
Mg content in liver | 2.8 | 2.9 | 7.1 | -1.1 | -2.5 | -1.3 | 1.3 | -2.7 | 1.9 | -1.7 | 1.7 | -1.7 | -2.6 | -1.6 | 0.2 | -1.2 | -1.1 | -1.4 |
Se content in liver | 2.8 | 3.4 | 14.1 | -2.0 | -3.1 | -0.8 | 0.8 | -3.8 | 1.5 | -1.2 | 1.3 | -1.2 | -2.4 | -1.2 | -1.2 | -2.0 | -1.0 | -1.4 |
Locomotion velocity, NPP test | 2.7 | 3.8 | 9.4 | 2.1 | 0.9 | -2.0 | 2.0 | 0.1 | 2.0 | -2.3 | 2.2 | -2.3 | -1.7 | -2.0 | 3.1 | 2.2 | -1.6 | -1.3 |
Epididymis fat weight | 2.6 | 6.0 | 20.0 | 2.7 | 4.5 | 1.4 | -1.4 | 4.2 | -2.1 | 1.8 | -1.8 | 1.8 | 3.5 | 1.7 | 0.9 | 2.9 | 1.0 | 1.5 |
Tibia length | 2.6 | 7.4 | 10.6 | -3.3 | -2.4 | 3.0 | -3.0 | 0.6 | -2.6 | 2.7 | -2.8 | 2.7 | 1.6 | 2.7 | -2.6 | -3.1 | 3.2 | 3.2 |
Condit. Reinf. inactive responses | 2.6 | 3.1 | 5.2 | 2.2 | 1.4 | -1.7 | 1.7 | -0.1 | 1.6 | -1.9 | 1.8 | -1.9 | -1.2 | -1.8 | 2.3 | 2.3 | -1.8 | -1.7 |
Pavlov. Cond. lever contacts | 2.6 | 3.1 | 6.7 | -0.8 | -2.2 | -1.7 | 1.7 | -2.5 | 2.1 | -1.9 | 1.9 | -1.9 | -2.6 | -1.6 | 0.5 | -0.7 | -1.2 | -1.5 |
One hour access (0.3 mA shock) | 2.5 | 2.9 | 6.0 | 1.0 | 0.1 | -2.5 | 2.5 | -1.0 | 2.1 | -1.8 | 1.8 | -1.8 | -1.7 | -2.0 | 1.6 | 0.8 | -1.7 | -1.5 |
Time in familiar zone, hab. session 1 | 2.5 | 2.3 | 5.9 | 2.3 | 2.2 | -1.3 | 1.3 | 0.2 | 1.1 | -1.2 | 1.3 | -1.2 | -0.2 | -1.2 | 1.4 | 2.4 | -1.8 | -1.8 |
Bone: apparent density | 2.5 | 4.1 | 7.5 | 2.7 | 1.9 | -2.1 | 2.1 | 0.2 | 1.7 | -2.0 | 2.0 | -2.0 | -1.1 | -2.0 | 2.7 | 2.6 | -2.0 | -1.8 |
Short access day 10 total locomotion | 2.4 | 2.6 | 6.8 | -2.5 | -2.1 | 1.2 | -1.2 | -0.5 | -1.2 | 1.4 | -1.4 | 1.4 | 0.4 | 1.3 | -2.1 | -2.6 | 1.6 | 1.5 |
Locomotion distance, session 3 | 2.4 | 2.6 | 3.4 | 1.4 | 0.5 | -1.8 | 1.8 | -1.2 | 1.8 | -1.8 | 1.8 | -1.9 | -1.5 | -1.8 | 1.5 | 1.5 | -1.9 | -1.5 |
Time to tail flick, test, after self-admin | 2.4 | 2.4 | 4.5 | 1.1 | 0.3 | -1.5 | 1.5 | -1.3 | 1.6 | -1.8 | 1.8 | -1.8 | -1.6 | -1.8 | 1.2 | 1.1 | -1.9 | -2.1 |
Stereotopy head waving duration, day 3 | 2.2 | 2.7 | 5.4 | -2.0 | -1.3 | 1.6 | -1.6 | 0.1 | -1.5 | 1.7 | -1.7 | 1.7 | 1.1 | 1.7 | -2.3 | -2.0 | 1.6 | 1.2 |
Bone: trabecular thickness | 2.2 | 2.7 | 5.3 | 2.3 | 1.7 | -1.6 | 1.6 | 0.4 | 1.3 | -1.6 | 1.5 | -1.6 | -0.8 | -1.5 | 2.3 | 2.3 | -1.5 | -1.4 |
Left kidney weight | 2.1 | 5.9 | 8.7 | -1.3 | 0.1 | 2.7 | -2.7 | 2.5 | -2.6 | 2.8 | -2.8 | 2.8 | 2.7 | 2.9 | -1.6 | -1.2 | 2.9 | 2.9 |
Condit. Reinf. active-inactive response ratio | 2.1 | 2.2 | 4.6 | -2.0 | -1.4 | 1.4 | -1.4 | -0.1 | -1.2 | 1.5 | -1.5 | 1.5 | 0.9 | 1.6 | -2.1 | -1.9 | 1.5 | 1.3 |
Right kidney weight | 2.0 | 5.6 | 7.8 | -1.6 | -0.3 | 2.6 | -2.6 | 2.2 | -2.6 | 2.7 | -2.8 | 2.7 | 2.4 | 2.7 | -1.8 | -1.6 | 2.8 | 2.8 |
Intermittent access standard deviation | 2.0 | 2.2 | 3.7 | -0.3 | 0.8 | 1.6 | -1.6 | 1.5 | -1.7 | 1.8 | -1.7 | 1.8 | 1.9 | 1.7 | -1.1 | -0.3 | 1.4 | 1.4 |
Compulsive drug intake | 2.0 | 2.0 | 4.1 | -0.3 | -1.3 | -1.7 | 1.7 | -1.9 | 1.4 | -1.4 | 1.4 | -1.4 | -2.0 | -1.7 | 0.8 | -0.8 | -1.1 | -0.9 |
Incentive salience index mean | 2.0 | 2.4 | 4.3 | 0.1 | -1.0 | -1.6 | 1.6 | -2.1 | 1.9 | -1.8 | 1.8 | -1.8 | -2.0 | -1.7 | 0.9 | 0.1 | -1.5 | -1.5 |
Locomotion velocity, hab. session 2 | 2.0 | 2.7 | 5.1 | 1.4 | 0.3 | -1.8 | 1.8 | -0.4 | 1.7 | -2.0 | 1.9 | -1.9 | -1.8 | -2.0 | 2.3 | 1.2 | -1.5 | -1.3 |
Delta distance traveled before/after self-admin | 2.0 | 2.2 | 6.0 | -1.4 | -0.4 | 1.9 | -1.9 | -0.3 | -1.6 | 1.7 | -1.5 | 1.6 | 1.3 | 1.5 | -2.5 | -1.3 | 1.0 | 0.7 |
Co content in liver | 2.0 | 2.4 | 4.4 | -0.1 | 0.9 | 1.7 | -1.7 | 2.1 | -1.8 | 1.7 | -1.7 | 1.7 | 2.0 | 1.7 | -0.6 | -0.1 | 1.6 | 1.6 |
Length with tail | 1.9 | 7.1 | 10.2 | -3.2 | -2.1 | 2.4 | -2.4 | 0.8 | -2.2 | 2.9 | -2.9 | 2.9 | 1.9 | 3.0 | -3.0 | -3.0 | 3.2 | 3.1 |
Pavlov. Cond. response bias | 1.9 | 2.3 | 7.1 | -1.0 | -2.0 | -1.3 | 1.3 | -2.7 | 1.7 | -1.4 | 1.4 | -1.4 | -2.1 | -1.3 | -0.2 | -0.9 | -1.1 | -1.4 |
Bone: connectivity density | 1.9 | 2.9 | 7.2 | 2.2 | 1.3 | -1.8 | 1.8 | 0.4 | 1.5 | -1.8 | 1.7 | -1.8 | -1.1 | -1.7 | 2.7 | 2.0 | -1.4 | -1.2 |
Distance traveled after self-admin | 1.9 | 2.1 | 3.3 | -1.4 | -0.7 | 1.8 | -1.8 | 0.4 | -1.7 | 1.6 | -1.5 | 1.6 | 1.1 | 1.3 | -1.6 | -1.6 | 1.4 | 1.4 |
Time >=10cm from walls, locomotor time 2 | 1.9 | 2.0 | 4.1 | -1.5 | -1.2 | 1.5 | -1.5 | 0.6 | -1.4 | 1.4 | -1.5 | 1.4 | 0.9 | 1.4 | -1.1 | -1.6 | 1.8 | 2.0 |
Seeking ratio, punishment vs. effort | 1.9 | 2.3 | 4.2 | 0.1 | -1.1 | -1.3 | 1.3 | -2.0 | 1.8 | -1.8 | 1.9 | -1.9 | -2.1 | -1.6 | 0.7 | 0.3 | -1.5 | -1.8 |
Mn content in liver | 1.9 | 2.1 | 10.5 | -2.3 | -3.2 | -0.2 | 0.2 | -2.2 | 0.7 | -0.5 | 0.5 | -0.6 | -1.8 | -0.5 | -0.8 | -2.4 | 0.2 | 0.2 |
Indifference point 0 sec | 1.8 | 2.8 | 5.6 | -0.1 | 1.3 | 1.9 | -1.9 | 1.8 | -2.0 | 2.0 | -1.9 | 2.0 | 2.4 | 1.9 | -1.3 | 0.0 | 1.4 | 1.4 |
Delay discounting total patch changes 0 sec | 1.8 | 2.9 | 5.9 | 0.0 | 1.4 | 1.9 | -1.9 | 1.9 | -2.0 | 2.0 | -2.0 | 2.0 | 2.4 | 1.9 | -1.3 | 0.1 | 1.4 | 1.3 |
Locomotion velocity, session 8 | 1.8 | 2.1 | 9.1 | -2.1 | -3.0 | -0.4 | 0.4 | -2.6 | 0.9 | -0.7 | 0.7 | -0.8 | -1.9 | -0.7 | -0.7 | -2.1 | -0.1 | -0.2 |
Time >=10cm from walls, locomotor time 1 | 1.8 | 1.8 | 4.5 | -1.3 | -1.0 | 1.3 | -1.3 | 1.1 | -1.4 | 1.3 | -1.4 | 1.3 | 0.8 | 1.3 | -0.5 | -1.5 | 1.8 | 2.1 |
Liver weight, right | 1.7 | 2.8 | 9.0 | -2.9 | -2.7 | 1.2 | -1.2 | -1.1 | -0.8 | 1.1 | -1.1 | 1.1 | -0.1 | 1.1 | -2.2 | -3.0 | 1.4 | 1.0 |
Locomotor activity | 1.7 | 2.7 | 5.9 | -2.2 | -1.5 | 1.9 | -1.9 | -0.6 | -1.6 | 1.6 | -1.5 | 1.6 | 0.8 | 1.4 | -2.4 | -2.2 | 1.3 | 1.1 |
Intermitt. access escalation Index | 1.7 | 1.5 | 2.5 | 0.4 | -0.5 | -1.5 | 1.5 | -1.1 | 1.5 | -1.4 | 1.4 | -1.4 | -1.6 | -1.5 | 1.2 | 0.2 | -1.1 | -1.1 |
Total locomotion distance, NPP test | 1.7 | 2.4 | 6.6 | 1.8 | 0.8 | -1.5 | 1.5 | 0.3 | 1.5 | -1.8 | 1.7 | -1.8 | -1.2 | -1.5 | 2.6 | 1.9 | -1.2 | -1.0 |
Pavlov. Cond. magazine entry latency | 1.7 | 2.2 | 8.2 | -1.2 | -2.0 | -1.1 | 1.1 | -2.9 | 1.5 | -1.1 | 1.2 | -1.2 | -1.9 | -1.2 | -0.8 | -1.2 | -1.1 | -1.5 |
Bone: final force | 1.7 | 2.7 | 5.2 | -0.1 | 1.0 | 1.7 | -1.7 | 2.3 | -2.0 | 1.8 | -1.9 | 1.9 | 2.0 | 1.6 | -0.5 | -0.3 | 1.7 | 2.0 |
Glucose | 1.6 | 2.5 | 13.0 | -2.4 | -3.6 | -0.4 | 0.4 | -2.3 | 1.1 | -0.8 | 0.8 | -0.9 | -2.1 | -0.5 | -0.5 | -2.3 | 0.3 | -0.0 |
Reaction time premature initiations | 1.6 | 2.3 | 4.2 | -0.3 | 0.6 | 1.3 | -1.3 | 2.0 | -1.5 | 1.7 | -1.8 | 1.8 | 2.0 | 1.9 | -0.8 | -0.1 | 1.8 | 1.9 |
Incentive Sensitization - Breakpoint | 1.6 | 1.6 | 2.6 | 1.2 | 0.7 | -1.6 | 1.6 | -0.5 | 1.3 | -1.2 | 1.3 | -1.2 | -1.0 | -1.5 | 1.2 | 0.9 | -1.5 | -1.4 |
Number of responses in last shaping day | 1.6 | 1.7 | 4.9 | -2.2 | -2.2 | 1.3 | -1.3 | -1.4 | -0.5 | 0.6 | -0.6 | 0.6 | -0.3 | 0.8 | -1.8 | -2.0 | 0.9 | 0.6 |
Locomotion distance, session 2 | 1.6 | 2.3 | 3.9 | 1.2 | 0.2 | -1.6 | 1.6 | -0.8 | 1.7 | -1.8 | 1.8 | -1.8 | -1.6 | -1.8 | 2.0 | 1.3 | -1.5 | -1.1 |
Total locomotion distance, hab. session 2 | 1.6 | 2.1 | 4.9 | 1.5 | 0.6 | -1.6 | 1.6 | -0.0 | 1.4 | -1.7 | 1.6 | -1.7 | -1.4 | -1.7 | 2.2 | 1.3 | -1.3 | -1.1 |
Bone: final moment | 1.6 | 2.6 | 4.5 | -0.1 | 0.9 | 1.7 | -1.7 | 2.1 | -2.0 | 1.8 | -1.8 | 1.8 | 2.0 | 1.7 | -0.6 | -0.2 | 1.6 | 1.9 |
Time to tail flick, vehicle, before self-admin | 1.6 | 1.6 | 3.1 | 1.0 | 0.3 | -1.6 | 1.6 | -0.4 | 1.2 | -1.4 | 1.3 | -1.3 | -1.3 | -1.7 | 1.7 | 0.5 | -1.3 | -0.9 |
Soleus weight | 1.5 | 4.3 | 18.9 | -3.7 | -4.3 | 1.0 | -1.0 | -1.5 | -0.3 | 0.6 | -0.7 | 0.6 | -1.1 | 0.8 | -1.7 | -3.9 | 1.8 | 1.5 |
Std. dev. time between licks in bursts | 1.5 | 1.8 | 8.6 | -2.4 | -2.9 | 0.3 | -0.3 | -1.6 | 0.1 | 0.1 | -0.1 | 0.1 | -1.0 | 0.2 | -1.3 | -2.5 | 0.7 | 0.4 |
Total zone transitions, NPP test | 1.5 | 2.1 | 3.5 | 1.2 | 0.2 | -1.6 | 1.6 | -0.6 | 1.6 | -1.8 | 1.7 | -1.7 | -1.5 | -1.6 | 1.9 | 1.2 | -1.4 | -1.1 |
Reaction time mean minus median AUC | 1.4 | 1.8 | 3.6 | 0.0 | -1.1 | -1.1 | 1.1 | -1.6 | 1.5 | -1.7 | 1.6 | -1.7 | -1.9 | -1.4 | 0.9 | 0.2 | -1.2 | -1.4 |
Social response proportion | 1.4 | 1.5 | 2.6 | -1.6 | -1.2 | 1.1 | -1.1 | 0.2 | -0.9 | 1.2 | -1.3 | 1.2 | 0.7 | 1.4 | -1.4 | -1.5 | 1.5 | 1.4 |
Intermitt. access day 15 inactive lever presses | 1.4 | 1.5 | 2.2 | -1.0 | -0.3 | 1.5 | -1.5 | 0.4 | -1.4 | 1.5 | -1.4 | 1.4 | 1.2 | 1.3 | -1.5 | -1.0 | 1.2 | 1.2 |
Baseline Anxiety | 1.4 | 1.5 | 2.9 | -1.4 | -0.8 | 1.5 | -1.5 | -0.0 | -1.2 | 1.3 | -1.2 | 1.3 | 0.9 | 1.3 | -1.7 | -1.3 | 1.1 | 0.9 |
Locomotion distance, session 1 | 1.4 | 1.9 | 2.8 | 1.5 | 0.8 | -1.3 | 1.3 | -0.5 | 1.3 | -1.5 | 1.5 | -1.5 | -1.1 | -1.5 | 1.7 | 1.5 | -1.5 | -1.3 |
Bone: endosteal perimeter | 1.4 | 2.9 | 9.8 | -3.0 | -3.1 | 1.0 | -1.0 | -1.1 | -0.6 | 0.9 | -1.0 | 0.9 | -0.4 | 0.9 | -1.8 | -3.1 | 1.5 | 1.4 |
Delay disc. indifference point, 4s delay | 1.4 | 1.5 | 3.5 | -1.6 | -1.1 | 1.0 | -1.0 | -0.3 | -0.9 | 1.3 | -1.3 | 1.3 | 0.7 | 1.1 | -1.9 | -1.7 | 1.1 | 1.0 |
BMI with tail | 1.3 | 4.2 | 8.7 | -0.1 | 1.1 | 2.1 | -2.1 | 3.0 | -2.4 | 2.2 | -2.3 | 2.3 | 2.5 | 2.2 | -0.4 | -0.1 | 2.3 | 2.6 |
Reaction time mean minus median | 1.3 | 1.6 | 3.6 | -0.3 | -1.3 | -1.0 | 1.0 | -1.8 | 1.3 | -1.5 | 1.5 | -1.5 | -1.9 | -1.4 | 0.5 | -0.4 | -1.1 | -1.3 |
Incentive Sensitization - Responses | 1.3 | 1.3 | 2.1 | 1.0 | 0.6 | -1.5 | 1.5 | -0.6 | 1.2 | -1.1 | 1.2 | -1.1 | -0.9 | -1.4 | 0.9 | 0.7 | -1.4 | -1.4 |
Stereotopy head waving bouts, day 3 | 1.3 | 1.6 | 4.1 | -1.9 | -1.5 | 1.0 | -1.0 | -0.3 | -0.9 | 1.2 | -1.1 | 1.1 | 0.4 | 1.0 | -1.6 | -2.0 | 1.2 | 1.0 |
Delta ambulatory time before/after self-admin | 1.3 | 1.4 | 4.4 | -1.4 | -0.8 | 1.4 | -1.4 | -0.6 | -1.2 | 1.2 | -1.1 | 1.2 | 0.7 | 1.0 | -2.1 | -1.4 | 0.7 | 0.6 |
Delay discounting total patch changes 18 sec | 1.2 | 1.6 | 7.3 | 1.9 | 2.7 | 0.2 | -0.2 | 2.2 | -0.8 | 0.6 | -0.6 | 0.6 | 1.6 | 0.4 | 0.8 | 1.8 | -0.0 | 0.2 |
Delay discounting total patch changes 6 sec | 1.2 | 1.8 | 4.1 | 0.4 | 1.6 | 1.4 | -1.4 | 1.7 | -1.6 | 1.5 | -1.5 | 1.5 | 2.0 | 1.4 | -0.8 | 0.5 | 0.9 | 0.9 |
Reaction time mean | 1.2 | 1.6 | 4.1 | -0.3 | -1.6 | -1.1 | 1.1 | -1.4 | 1.5 | -1.6 | 1.5 | -1.6 | -2.0 | -1.3 | 1.1 | -0.4 | -0.7 | -0.7 |
Std. dev. reaction times | 1.2 | 1.7 | 5.1 | -1.1 | -2.1 | -0.7 | 0.7 | -2.3 | 1.2 | -1.2 | 1.2 | -1.2 | -1.9 | -1.1 | -0.1 | -1.1 | -0.7 | -1.0 |
Social responses | 1.2 | 1.5 | 2.9 | -1.6 | -1.1 | 1.3 | -1.3 | -0.2 | -1.0 | 1.3 | -1.2 | 1.2 | 0.7 | 1.2 | -1.7 | -1.5 | 1.2 | 1.1 |
Condit. Reinf. active minus inactive responses | 1.2 | 1.5 | 3.6 | -1.5 | -0.7 | 1.2 | -1.2 | 0.0 | -1.0 | 1.4 | -1.3 | 1.4 | 1.0 | 1.4 | -1.9 | -1.3 | 1.2 | 1.1 |
Intermittent access intake escalation 2 | 1.2 | 1.1 | 2.6 | -0.4 | -1.1 | -1.1 | 1.1 | -1.6 | 1.2 | -1.1 | 1.1 | -1.1 | -1.5 | -1.2 | 0.2 | -0.5 | -0.9 | -1.1 |
Cocaine induced anxiety | 1.2 | 1.4 | 2.8 | 0.9 | 0.0 | -1.2 | 1.2 | -0.6 | 1.2 | -1.4 | 1.3 | -1.4 | -1.4 | -1.6 | 1.7 | 0.6 | -1.1 | -0.8 |
Progressive ratio test 2 breakpoint | 1.2 | 1.4 | 2.2 | 1.3 | 0.9 | -1.5 | 1.5 | -0.2 | 1.3 | -1.1 | 1.1 | -1.1 | -0.7 | -1.1 | 1.1 | 1.3 | -1.3 | -1.3 |
Bone: maximum force | 1.2 | 2.1 | 3.2 | -0.3 | 0.6 | 1.6 | -1.6 | 1.7 | -1.8 | 1.6 | -1.7 | 1.7 | 1.7 | 1.5 | -0.6 | -0.4 | 1.5 | 1.7 |
Bone: maximum moment | 1.2 | 2.0 | 3.0 | -0.4 | 0.5 | 1.6 | -1.6 | 1.5 | -1.7 | 1.6 | -1.6 | 1.6 | 1.7 | 1.6 | -0.8 | -0.4 | 1.5 | 1.6 |
Delay disc. indifference point, 2s delay | 1.2 | 1.4 | 3.9 | -2.0 | -1.7 | 0.4 | -0.4 | -0.9 | -0.2 | 1.0 | -0.9 | 1.0 | 0.2 | 1.0 | -1.9 | -1.9 | 1.0 | 0.8 |
Heart weight | 1.1 | 1.6 | 4.6 | -1.8 | -1.2 | 0.9 | -0.9 | -0.5 | -0.8 | 1.4 | -1.3 | 1.3 | 0.8 | 1.3 | -2.1 | -1.7 | 1.1 | 1.0 |
Times rat made contact with spout | 1.1 | 1.3 | 3.1 | 1.6 | 1.5 | -0.8 | 0.8 | -0.6 | 0.7 | -0.9 | 1.0 | -0.9 | -0.4 | -1.2 | 0.6 | 1.5 | -1.8 | -1.6 |
Delay discounting total patch changes 24 sec | 1.1 | 1.4 | 5.9 | 2.2 | 2.4 | -0.3 | 0.3 | 1.2 | 0.0 | -0.4 | 0.4 | -0.4 | 0.6 | -0.4 | 1.2 | 2.2 | -0.9 | -0.8 |
Reaction time mean AUC | 1.1 | 1.5 | 3.7 | -0.3 | -1.5 | -1.0 | 1.0 | -1.4 | 1.4 | -1.5 | 1.4 | -1.5 | -1.9 | -1.3 | 1.1 | -0.3 | -0.7 | -0.7 |
Reaction time false alarm rate | 1.1 | 1.6 | 6.1 | -1.6 | -2.3 | -0.3 | 0.3 | -2.5 | 0.7 | -0.6 | 0.6 | -0.6 | -1.6 | -0.8 | -1.0 | -1.9 | -0.5 | -0.8 |
Pavlov. Cond. change in total contacts | 1.1 | 1.1 | 4.5 | -1.2 | -1.7 | -0.7 | 0.7 | -2.1 | 1.0 | -0.6 | 0.7 | -0.6 | -1.3 | -0.6 | -0.9 | -1.2 | -0.6 | -0.9 |
Pavlov. Cond. magazine entry number | 1.1 | 1.3 | 5.1 | 0.9 | 1.5 | 0.8 | -0.8 | 2.3 | -1.1 | 0.9 | -1.0 | 0.9 | 1.5 | 0.9 | 0.6 | 0.9 | 0.9 | 1.2 |
Bone: cortical porosity | 1.1 | 1.2 | 5.4 | -1.7 | -1.3 | 0.6 | -0.6 | -1.6 | -0.3 | 0.7 | -0.5 | 0.6 | 0.1 | 0.6 | -2.3 | -1.6 | 0.2 | -0.4 |
Bone: minimum diameter | 1.1 | 2.1 | 6.0 | -2.4 | -2.4 | 1.1 | -1.1 | -0.5 | -0.8 | 1.0 | -1.0 | 1.0 | -0.1 | 1.0 | -1.5 | -2.5 | 1.5 | 1.4 |
Change in fecal boli incidents, locomotor task | 1.1 | 1.0 | 4.1 | -1.7 | -1.9 | 0.6 | -0.6 | -1.0 | -0.4 | 0.4 | -0.4 | 0.4 | -0.5 | 0.2 | -1.1 | -2.0 | 0.6 | 0.6 |
Length without tail | 1.0 | 2.3 | 5.7 | -0.7 | -0.2 | 1.4 | -1.4 | 2.2 | -1.4 | 1.5 | -1.7 | 1.5 | 1.4 | 1.7 | -0.1 | -0.6 | 2.2 | 2.4 |
Delay discounting total patch changes 12 sec | 1.0 | 1.4 | 2.9 | 0.1 | 1.1 | 1.2 | -1.2 | 1.3 | -1.4 | 1.4 | -1.3 | 1.4 | 1.7 | 1.3 | -1.0 | 0.1 | 0.8 | 0.6 |
Locomotor testing rearing | 1.0 | 1.6 | 2.7 | -1.1 | -0.7 | 1.6 | -1.6 | 0.8 | -1.5 | 1.3 | -1.3 | 1.3 | 1.0 | 1.4 | -0.9 | -1.1 | 1.5 | 1.4 |
Reaction time number correct | 1.0 | 1.4 | 3.4 | 0.5 | 1.4 | 0.9 | -0.9 | 1.8 | -1.3 | 1.3 | -1.3 | 1.3 | 1.8 | 1.2 | -0.4 | 0.5 | 0.9 | 1.1 |
Reaction time trials correct on left | 1.0 | 1.4 | 3.4 | 0.5 | 1.4 | 0.9 | -0.9 | 1.8 | -1.3 | 1.3 | -1.3 | 1.3 | 1.8 | 1.2 | -0.4 | 0.5 | 0.9 | 1.1 |
Reaction time trials on left | 1.0 | 1.4 | 3.3 | 0.4 | 1.3 | 0.9 | -0.9 | 1.8 | -1.3 | 1.3 | -1.3 | 1.3 | 1.8 | 1.3 | -0.4 | 0.5 | 1.0 | 1.1 |
Reaction time trials completed | 1.0 | 1.4 | 3.3 | 0.4 | 1.3 | 0.9 | -0.9 | 1.8 | -1.3 | 1.3 | -1.3 | 1.3 | 1.8 | 1.3 | -0.4 | 0.5 | 1.0 | 1.1 |
Social time | 1.0 | 1.4 | 4.3 | -1.1 | -2.1 | -0.8 | 0.8 | -1.8 | 0.9 | -0.9 | 0.9 | -0.9 | -1.8 | -1.1 | 0.1 | -1.4 | -0.4 | -0.4 |
Short access day 1 locomotion | 1.0 | 1.1 | 2.0 | 0.2 | -0.6 | -1.1 | 1.1 | -1.1 | 1.2 | -1.3 | 1.2 | -1.2 | -1.4 | -1.2 | 0.9 | 0.1 | -0.9 | -0.9 |
Pavlov. Cond. intertrial magazine entries | 1.0 | 1.2 | 4.6 | 1.9 | 2.1 | 0.1 | -0.1 | 1.7 | -0.3 | -0.1 | 0.0 | -0.1 | 0.9 | 0.1 | 1.4 | 2.1 | -0.2 | 0.2 |
Bone: periosteal perimeter | 1.0 | 1.6 | 5.3 | -2.1 | -2.0 | 0.9 | -0.9 | -0.6 | -0.7 | 0.9 | -0.9 | 0.9 | 0.0 | 0.8 | -1.6 | -2.3 | 1.2 | 1.1 |
Delta time in closed arm before/after self-admin | 1.0 | 0.9 | 1.9 | -0.9 | -0.5 | 1.0 | -1.0 | 0.8 | -1.0 | 1.0 | -1.0 | 1.0 | 0.8 | 1.1 | -0.5 | -0.8 | 1.3 | 1.4 |
Cd content in liver | 1.0 | 1.1 | 3.8 | 1.7 | 1.8 | 0.1 | -0.1 | 2.0 | -0.3 | -0.2 | 0.1 | -0.1 | 0.7 | 0.1 | 1.7 | 1.8 | 0.1 | 0.2 |
Fe content in liver | 1.0 | 1.2 | 4.0 | 0.7 | 1.5 | 0.8 | -0.8 | 2.0 | -1.0 | 0.9 | -1.0 | 1.0 | 1.6 | 1.2 | -0.0 | 0.9 | 0.9 | 0.5 |
Intraocular pressure | 0.9 | 1.3 | 3.1 | 1.8 | 1.6 | -1.3 | 1.3 | 1.1 | 0.8 | -0.7 | 0.7 | -0.7 | 0.0 | -0.7 | 1.6 | 1.7 | -0.7 | -0.6 |
Mean time between licks in bursts | 0.9 | 1.2 | 5.3 | -1.6 | -2.3 | -0.4 | 0.4 | -1.7 | 0.7 | -0.5 | 0.5 | -0.5 | -1.4 | -0.4 | -0.7 | -1.7 | 0.0 | -0.3 |
Mean num. licks in bursts | 0.9 | 1.1 | 5.5 | 1.7 | 2.4 | 0.3 | -0.3 | 1.3 | -0.5 | 0.3 | -0.2 | 0.3 | 1.2 | 0.2 | 0.4 | 1.9 | -0.4 | -0.3 |
Locomotor testing distance | 0.9 | 1.5 | 2.4 | -1.4 | -0.9 | 1.5 | -1.5 | -0.1 | -1.3 | 1.2 | -1.2 | 1.2 | 0.7 | 1.1 | -1.6 | -1.4 | 1.1 | 1.1 |
Reaction time trials AUC | 0.9 | 1.3 | 3.4 | 0.5 | 1.4 | 0.8 | -0.8 | 1.8 | -1.2 | 1.2 | -1.2 | 1.2 | 1.7 | 1.2 | -0.2 | 0.6 | 0.9 | 1.0 |
Cocaine response after cond. corrected | 0.9 | 1.0 | 3.6 | 1.0 | 0.2 | -1.1 | 1.1 | 0.2 | 0.9 | -1.2 | 1.1 | -1.1 | -1.0 | -1.2 | 1.9 | 0.7 | -0.6 | -0.3 |
Condit. Reinf. active responses | 0.9 | 1.1 | 1.8 | 0.9 | 0.5 | -1.0 | 1.0 | -1.0 | 1.2 | -1.2 | 1.2 | -1.2 | -0.9 | -1.2 | 0.8 | 1.1 | -1.3 | -1.2 |
Bone: cortical apparent density | 0.9 | 1.2 | 3.6 | 1.0 | 1.8 | 0.7 | -0.7 | 1.9 | -1.1 | 0.9 | -0.9 | 0.9 | 1.5 | 0.8 | 0.3 | 1.0 | 0.5 | 0.7 |
Bone: cortical tissue density | 0.9 | 1.2 | 3.3 | 0.8 | 1.6 | 0.8 | -0.8 | 1.8 | -1.2 | 1.0 | -1.0 | 1.0 | 1.5 | 0.9 | 0.1 | 0.8 | 0.6 | 0.8 |
Delta time to tail flick, test, before/after SA | 0.9 | 0.8 | 2.1 | 1.2 | 0.7 | -0.7 | 0.7 | 0.5 | 0.7 | -0.9 | 0.9 | -0.9 | -0.5 | -0.7 | 1.4 | 1.3 | -0.6 | -0.8 |
Ambulatory time after self-admin | 0.9 | 1.0 | 1.9 | -1.1 | -0.6 | 1.4 | -1.4 | -0.0 | -1.2 | 1.1 | -1.0 | 1.1 | 0.7 | 0.9 | -1.3 | -1.2 | 0.9 | 0.8 |
Delay disc. indifference point, 24s delay | 0.9 | 0.9 | 2.3 | -0.9 | -0.4 | 1.4 | -1.4 | -0.2 | -1.1 | 1.0 | -0.9 | 0.9 | 0.7 | 0.9 | -1.5 | -0.7 | 0.6 | 0.4 |
Bouts of movement, locomotor time 1 | 0.9 | 1.0 | 2.0 | 0.4 | -0.2 | -0.8 | 0.8 | -1.0 | 0.8 | -1.2 | 1.2 | -1.2 | -1.3 | -1.4 | 0.7 | 0.2 | -1.3 | -1.3 |
Latency to leave start box in cocaine runway, F | 0.9 | 1.0 | 2.0 | 0.1 | -0.7 | -1.4 | 1.4 | -1.0 | 1.4 | -1.1 | 1.1 | -1.1 | -1.3 | -1.0 | 0.8 | -0.0 | -0.7 | -0.7 |
Liver weight, left | 0.8 | 1.3 | 2.1 | -1.0 | -0.5 | 1.3 | -1.3 | 0.8 | -1.3 | 1.3 | -1.3 | 1.3 | 1.0 | 1.3 | -0.9 | -1.0 | 1.4 | 1.4 |
Number of licking bursts | 0.8 | 0.9 | 3.0 | -1.1 | -1.7 | -0.6 | 0.6 | -1.7 | 0.7 | -0.6 | 0.6 | -0.6 | -1.3 | -0.8 | -0.3 | -1.3 | -0.4 | -0.4 |
Delay discounting time to switch 0 sec | 0.8 | 1.2 | 5.1 | 1.6 | 1.8 | 0.2 | -0.2 | 2.3 | -0.5 | 0.1 | -0.3 | 0.2 | 0.9 | 0.2 | 1.7 | 1.6 | 0.4 | 1.0 |
Short access total locomotion | 0.8 | 0.8 | 1.6 | -1.3 | -1.1 | 0.8 | -0.8 | 0.1 | -0.6 | 0.8 | -0.8 | 0.8 | 0.3 | 0.9 | -0.9 | -1.2 | 1.1 | 1.1 |
Bone: cortical thickness | 0.8 | 0.9 | 3.7 | 1.3 | 1.9 | 0.6 | -0.6 | 1.5 | -1.0 | 0.6 | -0.6 | 0.6 | 1.2 | 0.3 | 0.5 | 1.1 | 0.1 | 0.5 |
Seeking ratio, delayed vs. immediate footshock | 0.8 | 0.9 | 2.8 | -0.9 | -0.2 | 0.7 | -0.7 | -0.1 | -1.1 | 1.2 | -1.1 | 1.2 | 0.9 | 0.8 | -1.7 | -1.3 | 0.6 | 0.5 |
Locomotion in novel chamber post-restriction | 0.8 | 0.9 | 1.9 | -0.2 | 0.5 | 0.4 | -0.4 | 1.4 | -0.8 | 1.2 | -1.2 | 1.2 | 1.3 | 1.3 | -0.4 | -0.1 | 1.2 | 1.3 |
K content in liver | 0.8 | 0.8 | 1.7 | 0.0 | -0.7 | -0.9 | 0.9 | -1.0 | 1.0 | -1.1 | 1.1 | -1.1 | -1.3 | -1.1 | 0.6 | -0.1 | -0.8 | -0.9 |
Median of all reaction times | 0.7 | 0.9 | 2.4 | -0.3 | -1.4 | -0.9 | 0.9 | -0.9 | 1.1 | -1.2 | 1.1 | -1.2 | -1.5 | -0.9 | 1.1 | -0.3 | -0.3 | -0.2 |
Reaction time omissions | 0.7 | 1.0 | 2.2 | -0.1 | -1.0 | -1.0 | 1.0 | -1.0 | 1.1 | -1.2 | 1.1 | -1.2 | -1.5 | -1.1 | 0.7 | -0.2 | -0.7 | -0.8 |
Pavlov. Cond. intertrial magazine entries | 0.7 | 0.9 | 2.9 | -0.9 | -1.4 | -0.6 | 0.6 | -1.7 | 0.8 | -0.7 | 0.7 | -0.7 | -1.3 | -0.8 | -0.4 | -1.1 | -0.6 | -0.6 |
Intermitt. access day 1 inactive lever presses | 0.7 | 0.8 | 2.4 | -1.3 | -1.3 | 0.7 | -0.7 | -0.2 | -0.6 | 0.6 | -0.7 | 0.7 | 0.0 | 0.6 | -0.6 | -1.5 | 1.0 | 1.1 |
Intermittent access day 1 total infusions | 0.7 | 0.8 | 1.5 | 0.8 | 0.3 | -1.1 | 1.1 | -0.4 | 1.2 | -1.0 | 1.0 | -1.0 | -0.7 | -0.7 | 0.8 | 1.1 | -0.8 | -0.9 |
Progressive ratio test 2 active lever presses | 0.7 | 0.8 | 1.5 | 0.9 | 0.6 | -1.2 | 1.2 | -0.2 | 1.1 | -0.8 | 0.8 | -0.8 | -0.5 | -0.9 | 0.8 | 0.9 | -0.9 | -0.9 |
Stereotopy head waving duration, day 7 | 0.7 | 0.8 | 2.9 | -1.1 | -0.6 | 0.8 | -0.8 | -0.3 | -0.7 | 1.0 | -0.9 | 1.0 | 0.6 | 0.9 | -1.7 | -1.2 | 0.6 | 0.5 |
Distance moved, locomotor task time 2 | 0.7 | 0.9 | 2.0 | 0.7 | 1.1 | 1.2 | -1.2 | 1.4 | -1.2 | 0.7 | -0.7 | 0.7 | 1.1 | 0.7 | 0.3 | 0.8 | 0.6 | 0.8 |
Vertical activity count, locomotor time 2 | 0.7 | 0.7 | 1.8 | 0.3 | 0.8 | 0.9 | -0.9 | 1.4 | -1.0 | 0.8 | -0.8 | 0.8 | 1.1 | 0.9 | -0.0 | 0.4 | 0.8 | 1.0 |
Sr content in liver | 0.7 | 0.6 | 1.3 | -0.9 | -0.7 | 0.9 | -0.9 | 0.9 | -0.7 | 0.6 | -0.7 | 0.7 | 0.5 | 0.9 | -0.4 | -0.7 | 1.1 | 0.8 |
Parametrial fat weight | 0.6 | 1.2 | 4.8 | 1.0 | 1.6 | 0.8 | -0.8 | 2.2 | -1.2 | 0.8 | -0.9 | 0.9 | 1.4 | 0.7 | 0.7 | 0.8 | 0.8 | 1.2 |
Locomotion velocity, session 2 | 0.6 | 0.7 | 1.9 | -0.2 | -0.8 | -0.8 | 0.8 | -1.4 | 1.0 | -0.8 | 0.8 | -0.8 | -1.1 | -0.9 | 0.1 | -0.3 | -0.8 | -0.7 |
Condit. Reinf. active minus inactive responses | 0.6 | 0.6 | 2.1 | 0.2 | -0.1 | -0.7 | 0.7 | -1.4 | 0.9 | -0.7 | 0.8 | -0.8 | -0.8 | -0.8 | -0.1 | 0.3 | -1.1 | -1.1 |
Bone: cortical porosity | 0.6 | 0.6 | 4.0 | -1.0 | -0.4 | 0.6 | -0.6 | -1.2 | -0.3 | 0.6 | -0.4 | 0.6 | 0.4 | 0.6 | -2.0 | -0.7 | -0.1 | -0.5 |
Bone: maximum diameter | 0.6 | 1.1 | 5.4 | -1.9 | -2.3 | 0.1 | -0.1 | -1.5 | 0.2 | -0.0 | 0.0 | -0.0 | -1.0 | -0.1 | -0.9 | -2.0 | 0.4 | 0.4 |
Delay discount hyperbolic model param | 0.6 | 0.6 | 2.2 | 1.2 | 0.9 | -0.5 | 0.5 | 0.8 | 0.2 | -0.7 | 0.6 | -0.6 | -0.2 | -0.5 | 1.5 | 1.2 | -0.3 | -0.2 |
Total resting periods, locomotor time 1 | 0.6 | 0.7 | 1.3 | 0.2 | -0.4 | -0.6 | 0.6 | -1.0 | 0.7 | -1.0 | 1.0 | -1.0 | -1.1 | -1.1 | 0.5 | -0.0 | -1.0 | -1.0 |
Total resting periods, locomotor time 2 | 0.6 | 0.6 | 2.3 | -1.3 | -1.1 | 0.1 | -0.1 | -1.5 | -0.1 | 0.3 | -0.2 | 0.3 | -0.3 | 0.1 | -1.5 | -1.4 | -0.0 | -0.2 |
Na content in liver | 0.6 | 0.6 | 1.0 | 0.3 | -0.2 | -1.0 | 1.0 | -0.8 | 0.9 | -0.9 | 0.9 | -0.9 | -1.0 | -1.0 | 0.5 | 0.0 | -0.9 | -1.0 |
Reaction time num false alarms AUC | 0.5 | 0.7 | 2.7 | -1.4 | -1.5 | 0.1 | -0.1 | -1.5 | -0.0 | 0.1 | -0.0 | 0.1 | -0.6 | -0.2 | -1.2 | -1.6 | -0.0 | -0.3 |
Reaction time premature initiation rate | 0.5 | 0.7 | 1.6 | -0.5 | -0.1 | 0.7 | -0.7 | 1.0 | -0.7 | 0.9 | -1.0 | 0.9 | 0.9 | 1.1 | -0.4 | -0.3 | 1.2 | 1.3 |
Conditioned locomotion | 0.5 | 0.6 | 1.4 | -0.7 | -0.6 | 0.8 | -0.8 | 0.7 | -0.8 | 0.7 | -0.8 | 0.7 | 0.5 | 0.7 | -0.2 | -0.8 | 1.1 | 1.2 |
Total locomotion distance, hab. session 1 | 0.5 | 0.8 | 1.2 | 0.7 | 0.1 | -1.0 | 1.0 | -0.3 | 0.9 | -1.1 | 1.0 | -1.1 | -0.9 | -1.0 | 1.1 | 0.7 | -0.8 | -0.8 |
Bone: cortical thickness | 0.5 | 0.8 | 3.4 | 1.1 | 1.8 | 0.6 | -0.6 | 1.4 | -0.9 | 0.6 | -0.6 | 0.7 | 1.2 | 0.4 | 0.2 | 1.0 | 0.0 | 0.3 |
Bone: trabecular tissue density | 0.5 | 0.7 | 3.2 | -1.2 | -0.6 | 0.6 | -0.6 | -0.5 | -0.6 | 0.9 | -0.8 | 0.9 | 0.6 | 0.9 | -1.8 | -1.1 | 0.5 | -0.0 |
Breakpoint value in progressive ratio session | 0.5 | 0.5 | 1.0 | -0.0 | -0.5 | -1.0 | 1.0 | -0.9 | 1.0 | -0.8 | 0.8 | -0.8 | -0.9 | -0.8 | 0.4 | -0.1 | -0.6 | -0.6 |
Time in open arm before self-admin | 0.5 | 0.6 | 2.1 | -0.3 | -0.6 | -0.8 | 0.8 | -1.5 | 0.8 | -0.6 | 0.7 | -0.6 | -0.8 | -0.6 | -0.4 | -0.3 | -0.8 | -0.9 |
Time to tail flick, vehicle, after self-admin | 0.5 | 0.6 | 1.3 | -0.2 | -0.9 | -0.8 | 0.8 | -0.9 | 0.7 | -0.8 | 0.8 | -0.8 | -1.2 | -0.9 | 0.5 | -0.4 | -0.5 | -0.4 |
Run reversals in cocaine runway, females | 0.5 | 0.5 | 2.2 | 1.1 | 1.5 | -0.1 | 0.1 | 1.2 | -0.0 | 0.1 | -0.1 | 0.1 | 0.7 | 0.3 | 0.6 | 1.3 | -0.0 | -0.0 |
Latency to leave start box in cocaine runway | 0.5 | 0.6 | 1.2 | -0.4 | -1.0 | -0.9 | 0.9 | -1.0 | 1.0 | -0.8 | 0.7 | -0.8 | -1.1 | -0.7 | 0.4 | -0.4 | -0.4 | -0.3 |
Retroperitoneal fat weight | 0.4 | 1.2 | 2.0 | -0.2 | 0.5 | 1.2 | -1.2 | 1.3 | -1.1 | 1.2 | -1.2 | 1.2 | 1.4 | 1.4 | -0.5 | 0.0 | 1.2 | 1.4 |
Indifference point AUC | 0.4 | 0.5 | 2.2 | -1.0 | -0.7 | 0.3 | -0.3 | -0.8 | -0.4 | 0.6 | -0.5 | 0.6 | 0.2 | 0.3 | -1.5 | -1.2 | 0.2 | -0.1 |
Indifference point function ln k | 0.4 | 0.5 | 1.9 | -0.8 | -1.2 | -0.4 | 0.4 | -1.4 | 0.7 | -0.5 | 0.5 | -0.5 | -0.9 | -0.5 | -0.4 | -0.8 | -0.4 | -0.4 |
Indifference point function log k | 0.4 | 0.5 | 1.9 | -0.8 | -1.2 | -0.4 | 0.4 | -1.4 | 0.7 | -0.5 | 0.5 | -0.5 | -0.9 | -0.5 | -0.4 | -0.8 | -0.4 | -0.4 |
Delay discounting water rate 12 sec | 0.4 | 0.6 | 1.4 | 1.2 | 1.0 | -0.8 | 0.8 | 0.0 | 0.6 | -0.7 | 0.7 | -0.6 | -0.2 | -0.8 | 0.8 | 1.0 | -0.9 | -0.8 |
Intermittent access day 15 total infusions | 0.4 | 0.5 | 0.8 | 0.8 | 0.6 | -0.9 | 0.9 | -0.0 | 0.8 | -0.7 | 0.7 | -0.7 | -0.3 | -0.6 | 0.7 | 0.9 | -0.7 | -0.8 |
Short access day 1 total inactive lever presses | 0.4 | 0.4 | 2.6 | -1.0 | -1.6 | 0.3 | -0.3 | -0.8 | 0.5 | -0.4 | 0.3 | -0.4 | -0.8 | 0.2 | -0.1 | -0.6 | 0.4 | 0.2 |
Locomotion velocity, session 1 | 0.4 | 0.5 | 1.8 | -0.5 | -0.9 | -0.4 | 0.4 | -1.3 | 0.7 | -0.6 | 0.7 | -0.7 | -0.9 | -0.5 | -0.4 | -0.3 | -0.6 | -0.7 |
Stereotopy head waving bouts, day 7 | 0.4 | 0.5 | 2.6 | -1.0 | -0.6 | 0.4 | -0.4 | -0.8 | -0.3 | 0.6 | -0.5 | 0.6 | 0.3 | 0.4 | -1.6 | -1.0 | 0.1 | -0.2 |
Total zone transitions, hab. session 1 | 0.4 | 0.6 | 0.9 | 0.4 | -0.1 | -0.9 | 0.9 | -0.7 | 0.8 | -0.9 | 0.9 | -0.9 | -0.9 | -0.9 | 0.7 | 0.3 | -0.8 | -0.8 |
Bone: post-yield work | 0.4 | 0.6 | 1.4 | -1.1 | -1.1 | 0.6 | -0.6 | 0.1 | -0.5 | 0.5 | -0.6 | 0.6 | 0.1 | 0.6 | -0.5 | -1.2 | 1.0 | 0.9 |
Bone: stiffness | 0.4 | 0.7 | 2.2 | 0.5 | 1.1 | 0.6 | -0.6 | 1.5 | -1.0 | 0.8 | -0.9 | 0.9 | 1.1 | 0.6 | 0.2 | 0.3 | 0.6 | 1.0 |
Time to tail flick, test, before self-admin | 0.4 | 0.4 | 0.8 | 0.8 | 0.7 | -0.8 | 0.8 | -0.3 | 0.5 | -0.5 | 0.6 | -0.5 | -0.3 | -0.8 | 0.5 | 0.5 | -0.9 | -0.7 |
Delay discount exponential model param | 0.4 | 0.4 | 1.5 | 1.0 | 0.7 | -0.4 | 0.4 | 0.7 | 0.2 | -0.6 | 0.5 | -0.5 | -0.2 | -0.4 | 1.2 | 1.0 | -0.3 | -0.2 |
Rest time, locomotor task time 2 | 0.4 | 0.4 | 1.9 | -0.7 | -1.4 | -0.1 | 0.1 | -0.6 | 0.4 | -0.6 | 0.5 | -0.6 | -1.1 | -0.5 | 0.4 | -0.9 | 0.0 | -0.1 |
Food consumed during 24 hour testing period | 0.3 | 0.4 | 1.4 | -0.7 | -0.7 | 0.7 | -0.7 | 0.4 | -0.6 | 0.4 | -0.5 | 0.5 | 0.1 | 0.4 | 0.1 | -0.8 | 0.9 | 1.2 |
Reaction time num false alarms | 0.3 | 0.4 | 1.4 | -0.9 | -1.2 | -0.1 | 0.1 | -1.2 | 0.2 | -0.2 | 0.2 | -0.2 | -0.7 | -0.4 | -0.6 | -1.1 | -0.2 | -0.4 |
Condit. Reinf. active responses | 0.3 | 0.4 | 1.2 | -0.6 | -0.1 | 0.5 | -0.5 | 0.1 | -0.5 | 0.8 | -0.7 | 0.7 | 0.6 | 0.8 | -1.1 | -0.5 | 0.5 | 0.5 |
Pavlov. Cond. response bias | 0.3 | 0.4 | 1.0 | 0.8 | 0.7 | -0.6 | 0.6 | -0.4 | 0.6 | -0.5 | 0.6 | -0.5 | -0.2 | -0.6 | 0.2 | 0.8 | -0.9 | -1.0 |
Conditioned reinforcement - inactives | 0.3 | 0.4 | 0.9 | -0.0 | 0.5 | 0.6 | -0.6 | 0.6 | -0.6 | 0.7 | -0.7 | 0.7 | 0.9 | 0.8 | -0.6 | 0.2 | 0.5 | 0.3 |
Intermittent access day 15 total locomotion | 0.3 | 0.4 | 0.6 | -0.2 | 0.1 | 0.6 | -0.6 | 0.7 | -0.8 | 0.7 | -0.7 | 0.7 | 0.7 | 0.6 | -0.4 | -0.3 | 0.7 | 0.7 |
Locomotion velocity, hab. session 1 | 0.3 | 0.4 | 0.7 | 0.4 | 0.0 | -0.7 | 0.7 | -0.3 | 0.7 | -0.8 | 0.8 | -0.8 | -0.7 | -0.7 | 0.7 | 0.4 | -0.7 | -0.7 |
Time in novel zone, hab. session 2 | 0.3 | 0.3 | 0.7 | -0.6 | -0.4 | 0.7 | -0.7 | 0.2 | -0.5 | 0.6 | -0.6 | 0.6 | 0.5 | 0.8 | -0.7 | -0.4 | 0.7 | 0.5 |
Total zone transitions, hab. session 2 | 0.3 | 0.4 | 1.4 | 0.8 | 0.3 | -0.7 | 0.7 | 0.3 | 0.5 | -0.7 | 0.7 | -0.7 | -0.6 | -0.8 | 1.2 | 0.5 | -0.5 | -0.3 |
Area under the delay curve | 0.3 | 0.3 | 1.0 | -0.8 | -0.7 | 0.3 | -0.3 | -0.6 | -0.1 | 0.4 | -0.3 | 0.4 | 0.1 | 0.3 | -1.0 | -0.9 | 0.2 | 0.2 |
Delay disc. indifference point, 0s delay | 0.3 | 0.3 | 1.4 | -0.8 | -1.2 | -0.1 | 0.1 | -0.7 | 0.3 | -0.2 | 0.2 | -0.3 | -0.7 | -0.2 | -0.1 | -0.8 | 0.1 | 0.1 |
Rest time, locomotor task time 1 | 0.3 | 0.3 | 0.9 | -0.7 | -0.6 | 0.9 | -0.9 | -0.5 | -0.6 | 0.3 | -0.2 | 0.2 | 0.0 | 0.4 | -0.7 | -0.5 | 0.3 | 0.1 |
Vertical activity count, locomotor time 1 | 0.3 | 0.3 | 1.2 | 0.4 | 0.8 | 0.2 | -0.2 | 1.1 | -0.6 | 0.6 | -0.6 | 0.6 | 0.8 | 0.4 | 0.1 | 0.2 | 0.4 | 0.7 |
Bouts of movement, locomotor time 2 | 0.3 | 0.4 | 1.6 | -0.9 | -0.6 | 0.0 | -0.0 | -1.0 | -0.2 | 0.5 | -0.4 | 0.4 | 0.1 | 0.2 | -1.2 | -1.0 | 0.0 | -0.1 |
Run reversals in cocaine runway, males | 0.3 | 0.3 | 0.7 | -0.4 | -0.8 | -0.4 | 0.4 | -0.9 | 0.6 | -0.5 | 0.5 | -0.5 | -0.8 | -0.4 | -0.0 | -0.4 | -0.2 | -0.3 |
Water consumed over 24 hours | 0.2 | 0.2 | 0.9 | -0.6 | -1.0 | 0.1 | -0.1 | -0.8 | 0.1 | -0.2 | 0.2 | -0.2 | -0.6 | -0.2 | -0.2 | -0.7 | 0.0 | 0.1 |
Light reinforcement 1 | 0.2 | 0.4 | 2.3 | 0.7 | 0.8 | 0.3 | -0.3 | 1.5 | -0.6 | 0.2 | -0.3 | 0.3 | 0.5 | 0.0 | 0.9 | 0.3 | 0.4 | 0.7 |
Light reinforcement 2 | 0.2 | 0.3 | 1.0 | 0.1 | 0.0 | 0.7 | -0.7 | 1.0 | -0.6 | 0.2 | -0.3 | 0.3 | 0.3 | 0.2 | 0.6 | -0.0 | 0.6 | 1.0 |
Cocaine response after cond. not corrected | 0.2 | 0.2 | 1.1 | -0.8 | -1.0 | 0.1 | -0.1 | -0.2 | -0.1 | 0.1 | -0.2 | 0.1 | -0.4 | -0.0 | -0.1 | -1.1 | 0.5 | 0.5 |
Condit. Reinf. lever reinforcers received | 0.2 | 0.3 | 1.3 | -0.7 | -0.3 | 0.4 | -0.4 | -0.3 | -0.3 | 0.6 | -0.5 | 0.6 | 0.4 | 0.6 | -1.1 | -0.6 | 0.3 | 0.2 |
Pavlov. Cond. lever contacts | 0.2 | 0.3 | 1.6 | 0.9 | 1.3 | -0.1 | 0.1 | 0.2 | -0.0 | -0.0 | 0.1 | -0.0 | 0.5 | -0.1 | 0.1 | 1.0 | -0.6 | -0.5 |
Conditioned reinforcement - actives | 0.2 | 0.2 | 0.6 | -0.3 | -0.1 | 0.3 | -0.3 | 0.5 | -0.2 | 0.5 | -0.6 | 0.5 | 0.5 | 0.7 | -0.3 | -0.1 | 0.7 | 0.7 |
Intermittent access total locomotion | 0.2 | 0.3 | 1.1 | 0.5 | 0.7 | 0.1 | -0.1 | 1.1 | -0.3 | 0.3 | -0.3 | 0.3 | 0.6 | 0.4 | 0.3 | 0.6 | 0.4 | 0.5 |
Short access day 10 total inactive lever presses | 0.2 | 0.3 | 0.8 | -0.4 | -0.7 | -0.5 | 0.5 | -0.7 | 0.3 | -0.3 | 0.3 | -0.2 | -0.7 | -0.6 | 0.1 | -0.9 | -0.2 | -0.1 |
One hour access (shock baseline) | 0.2 | 0.2 | 0.8 | 0.6 | 0.9 | -0.0 | 0.0 | 0.9 | 0.1 | 0.1 | -0.1 | 0.1 | 0.5 | 0.3 | 0.3 | 0.9 | 0.1 | -0.0 |
Degree of sensitization distance | 0.2 | 0.3 | 1.1 | -0.6 | -1.1 | -0.2 | 0.2 | -0.7 | 0.3 | -0.4 | 0.3 | -0.3 | -0.7 | -0.3 | -0.0 | -0.8 | -0.0 | -0.2 |
Degree of sensitization stereotypy | 0.2 | 0.3 | 1.2 | -0.4 | -0.3 | -0.3 | 0.3 | -1.1 | 0.4 | -0.0 | 0.2 | -0.1 | -0.3 | -0.2 | -1.0 | -0.4 | -0.6 | -0.7 |
Time in familiar zone, hab. session 2 | 0.2 | 0.2 | 1.1 | 0.8 | 1.0 | -0.2 | 0.2 | 0.4 | -0.1 | -0.0 | 0.1 | -0.0 | 0.3 | -0.3 | 0.3 | 0.6 | -0.5 | -0.3 |
Bone: cortical area | 0.2 | 0.4 | 0.6 | -0.6 | -0.3 | 0.7 | -0.7 | 0.1 | -0.7 | 0.7 | -0.7 | 0.7 | 0.5 | 0.5 | -0.7 | -0.8 | 0.5 | 0.7 |
Bone: tissue strength | 0.2 | 0.2 | 0.8 | 0.3 | 0.5 | 0.4 | -0.4 | 0.9 | -0.4 | 0.3 | -0.4 | 0.3 | 0.6 | 0.5 | 0.3 | 0.5 | 0.5 | 0.6 |
Delta time in open arm before/after self-admin | 0.2 | 0.2 | 0.8 | 0.6 | 0.9 | 0.1 | -0.1 | 0.3 | -0.1 | 0.0 | 0.0 | -0.0 | 0.4 | 0.1 | 0.0 | 0.8 | -0.3 | -0.4 |
Extinction: sum of active levers before priming | 0.2 | 0.2 | 0.8 | -0.4 | -0.8 | -0.3 | 0.3 | -0.9 | 0.5 | -0.5 | 0.5 | -0.5 | -0.7 | -0.4 | 0.0 | -0.4 | -0.3 | -0.3 |
Active lever presses in extinction session 6 | 0.2 | 0.2 | 0.7 | 0.5 | 0.7 | 0.2 | -0.2 | 0.9 | -0.1 | 0.1 | -0.2 | 0.1 | 0.5 | 0.4 | 0.4 | 0.8 | 0.3 | 0.2 |
Time in closed arm after self-admin | 0.2 | 0.2 | 0.3 | -0.1 | 0.1 | 0.6 | -0.6 | 0.5 | -0.4 | 0.4 | -0.4 | 0.4 | 0.5 | 0.5 | -0.1 | 0.0 | 0.5 | 0.5 |
Time in open arm after self-admin | 0.2 | 0.2 | 0.9 | -0.3 | -0.2 | -0.0 | 0.0 | -1.0 | 0.3 | -0.1 | 0.2 | -0.2 | -0.2 | -0.0 | -0.8 | -0.0 | -0.5 | -0.7 |
Ambulatory time before self-admin | 0.2 | 0.2 | 0.8 | 0.5 | 0.2 | -0.5 | 0.5 | 0.3 | 0.3 | -0.4 | 0.4 | -0.4 | -0.3 | -0.4 | 0.9 | 0.4 | -0.2 | -0.1 |
Fecal boli incidents, locomotor time 1 | 0.2 | 0.2 | 0.9 | 0.6 | 0.7 | -0.4 | 0.4 | 0.7 | 0.3 | -0.1 | 0.0 | -0.0 | 0.4 | 0.3 | 0.6 | 0.9 | 0.2 | 0.2 |
Distance moved, locomotor task time 1 | 0.2 | 0.2 | 0.5 | 0.1 | 0.4 | 0.6 | -0.6 | 0.7 | -0.7 | 0.5 | -0.5 | 0.5 | 0.6 | 0.4 | -0.1 | -0.1 | 0.4 | 0.5 |
Rb content in liver | 0.2 | 0.3 | 1.6 | 0.4 | -0.1 | -0.3 | 0.3 | 0.6 | 0.4 | -0.7 | 0.6 | -0.7 | -0.5 | -0.4 | 1.2 | 0.4 | -0.0 | -0.1 |
Extensor digitorum longus weight | 0.1 | 0.5 | 1.5 | -1.1 | -1.2 | 0.6 | -0.6 | -0.1 | -0.3 | 0.4 | -0.4 | 0.4 | -0.1 | 0.5 | -0.4 | -1.1 | 0.9 | 0.9 |
Tibialis anterior weight | 0.1 | 0.3 | 1.6 | 1.1 | 1.2 | -0.2 | 0.2 | 0.5 | -0.0 | -0.1 | 0.1 | -0.1 | 0.3 | -0.3 | 0.6 | 1.0 | -0.4 | -0.0 |
Delay discounting water rate 0 sec | 0.1 | 0.2 | 0.4 | -0.6 | -0.4 | 0.4 | -0.4 | 0.1 | -0.3 | 0.5 | -0.5 | 0.5 | 0.3 | 0.5 | -0.7 | -0.6 | 0.5 | 0.3 |
Delay discounting water rate 18 sec | 0.1 | 0.1 | 0.3 | 0.0 | 0.3 | 0.4 | -0.4 | 0.5 | -0.4 | 0.4 | -0.4 | 0.4 | 0.5 | 0.4 | -0.3 | 0.0 | 0.2 | 0.2 |
Delay discounting water rate 6 sec | 0.1 | 0.1 | 0.3 | 0.6 | 0.5 | -0.4 | 0.4 | 0.1 | 0.2 | -0.2 | 0.3 | -0.2 | -0.1 | -0.3 | 0.4 | 0.5 | -0.4 | -0.3 |
Condit. Reinf. inactive responses | 0.1 | 0.2 | 0.9 | 0.8 | 0.9 | -0.1 | 0.1 | 0.5 | -0.0 | -0.0 | 0.0 | -0.0 | 0.3 | -0.1 | 0.3 | 0.7 | -0.3 | -0.1 |
Pavlov. Cond. lever latency | 0.1 | 0.1 | 0.3 | -0.4 | -0.5 | 0.1 | -0.1 | 0.3 | -0.2 | 0.1 | -0.2 | 0.1 | -0.1 | 0.1 | 0.2 | -0.5 | 0.5 | 0.5 |
Pavlov. Cond. magazine entry latency | 0.1 | 0.1 | 0.2 | -0.3 | -0.5 | -0.3 | 0.3 | -0.5 | 0.4 | -0.3 | 0.3 | -0.3 | -0.4 | -0.1 | -0.1 | -0.1 | -0.1 | -0.4 |
Pavlov. Cond. change in total contacts | 0.1 | 0.1 | 0.7 | -0.1 | 0.3 | 0.3 | -0.3 | -0.1 | -0.2 | 0.4 | -0.3 | 0.3 | 0.5 | 0.4 | -0.8 | 0.1 | -0.1 | -0.3 |
Pavlov. Cond. magazine entry number | 0.1 | 0.1 | 0.2 | -0.3 | -0.2 | 0.4 | -0.4 | -0.1 | -0.4 | 0.3 | -0.3 | 0.3 | 0.1 | 0.1 | -0.3 | -0.4 | 0.2 | 0.4 |
Conditioned locomotion | 0.1 | 0.1 | 0.3 | -0.2 | -0.2 | 0.2 | -0.2 | 0.5 | 0.1 | 0.2 | -0.2 | 0.2 | 0.2 | 0.6 | -0.0 | 0.1 | 0.6 | 0.6 |
Intermittent access intake day 1-15 change | 0.1 | 0.1 | 0.5 | 0.4 | 0.7 | -0.3 | 0.3 | -0.0 | -0.0 | 0.0 | 0.0 | 0.0 | 0.2 | -0.2 | -0.2 | 0.3 | -0.5 | -0.6 |
Intermittent access intake escalation | 0.1 | 0.1 | 0.3 | 0.2 | 0.2 | -0.5 | 0.5 | -0.3 | 0.3 | -0.3 | 0.3 | -0.3 | -0.3 | -0.5 | 0.1 | 0.1 | -0.5 | -0.6 |
Intermittent access total infusions | 0.1 | 0.1 | 0.7 | 0.5 | 0.5 | -0.3 | 0.3 | 0.3 | 0.4 | -0.2 | 0.2 | -0.2 | 0.1 | 0.1 | 0.2 | 0.8 | -0.2 | -0.3 |
Intermittent access day 1 locomotion | 0.1 | 0.1 | 0.2 | 0.2 | 0.2 | -0.0 | 0.0 | 0.5 | -0.1 | 0.1 | -0.1 | 0.1 | 0.2 | 0.2 | 0.2 | 0.4 | 0.2 | 0.3 |
Post-drug Anxiety | 0.1 | 0.1 | 0.3 | -0.2 | -0.5 | 0.2 | -0.2 | -0.1 | -0.0 | -0.2 | 0.1 | -0.1 | -0.4 | -0.2 | 0.4 | -0.5 | 0.1 | 0.3 |
Progressive ratio test 1 inactive lever presses | 0.1 | 0.1 | 0.4 | 0.5 | 0.7 | 0.3 | -0.3 | 0.4 | -0.4 | 0.1 | -0.1 | 0.1 | 0.3 | -0.0 | 0.3 | 0.4 | -0.1 | 0.0 |
Short access day 1 total infusions | 0.1 | 0.1 | 0.7 | -0.6 | -0.8 | 0.0 | -0.0 | -0.6 | 0.5 | -0.2 | 0.2 | -0.3 | -0.4 | 0.3 | -0.4 | -0.0 | 0.1 | -0.2 |
Short access total infusions | 0.1 | 0.2 | 0.5 | -0.7 | -0.6 | 0.3 | -0.3 | -0.3 | 0.1 | 0.2 | -0.2 | 0.2 | 0.1 | 0.6 | -0.7 | -0.2 | 0.4 | 0.2 |
Locomotion velocity, session 3 | 0.1 | 0.1 | 0.4 | 0.2 | 0.6 | 0.3 | -0.3 | 0.0 | -0.3 | 0.4 | -0.3 | 0.3 | 0.5 | 0.2 | -0.4 | 0.4 | -0.1 | 0.1 |
Condit. Reinf. active-inactive response ratio | 0.1 | 0.1 | 0.4 | 0.1 | 0.4 | 0.2 | -0.2 | -0.2 | -0.2 | 0.4 | -0.3 | 0.3 | 0.4 | 0.2 | -0.6 | 0.1 | -0.2 | -0.1 |
Novel to familiar place preference ratio | 0.1 | 0.1 | 0.5 | 0.1 | -0.1 | -0.4 | 0.4 | -0.5 | 0.4 | -0.4 | 0.4 | -0.4 | -0.4 | -0.4 | -0.0 | 0.0 | -0.5 | -0.7 |
Novelty place preference | 0.1 | 0.1 | 0.4 | -0.2 | -0.3 | -0.2 | 0.2 | -0.6 | 0.2 | -0.2 | 0.2 | -0.2 | -0.3 | -0.2 | -0.4 | -0.3 | -0.3 | -0.6 |
Time in novel zone, NPP test | 0.1 | 0.1 | 0.5 | -0.4 | -0.4 | 0.0 | -0.0 | -0.6 | 0.0 | 0.1 | -0.0 | 0.0 | -0.1 | 0.1 | -0.7 | -0.5 | -0.1 | -0.4 |
Bone volume | 0.1 | 0.2 | 0.7 | 0.9 | 0.8 | -0.4 | 0.4 | 0.4 | 0.2 | -0.3 | 0.3 | -0.3 | 0.1 | -0.4 | 0.8 | 0.7 | -0.3 | -0.2 |
Bone: elastic displacement | 0.1 | 0.1 | 0.5 | 0.5 | 0.7 | -0.1 | 0.1 | -0.1 | 0.1 | -0.0 | 0.1 | -0.1 | 0.3 | 0.0 | -0.2 | 0.7 | -0.5 | -0.6 |
Bone: elastic work | 0.1 | 0.2 | 0.3 | -0.1 | 0.2 | 0.5 | -0.5 | 0.3 | -0.5 | 0.5 | -0.4 | 0.4 | 0.5 | 0.5 | -0.4 | -0.1 | 0.3 | 0.2 |
Distance traveled before self-admin | 0.1 | 0.1 | 0.6 | 0.0 | -0.2 | -0.2 | 0.2 | 0.6 | -0.1 | -0.1 | -0.0 | -0.0 | -0.1 | -0.1 | 0.7 | -0.2 | 0.4 | 0.6 |
Time in closed arm before self-admin | 0.1 | 0.1 | 0.3 | -0.3 | -0.3 | 0.5 | -0.5 | -0.1 | -0.2 | 0.2 | -0.2 | 0.2 | 0.1 | 0.3 | -0.4 | -0.2 | 0.2 | 0.1 |
Sum of active levers in priming session hrs 5-6 | 0.1 | 0.1 | 0.6 | -0.7 | -0.8 | 0.2 | -0.2 | -0.6 | 0.2 | 0.0 | -0.0 | -0.0 | -0.2 | 0.3 | -0.5 | -0.4 | 0.2 | -0.0 |
Delta time to tail flick, vehicle, before/after SA | 0.1 | 0.1 | 0.3 | 0.1 | -0.1 | -0.3 | 0.3 | -0.5 | 0.5 | -0.4 | 0.5 | -0.5 | -0.3 | -0.1 | 0.1 | 0.4 | -0.3 | -0.6 |
Total heroin consumption | 0.1 | 0.1 | 0.5 | 0.1 | 0.0 | -0.7 | 0.7 | -0.1 | 0.5 | -0.1 | 0.1 | -0.1 | -0.1 | -0.1 | 0.1 | 0.1 | -0.1 | -0.1 |
Delay disc. indifference point, 16s delay | 0.1 | 0.1 | 0.3 | 0.3 | 0.5 | 0.4 | -0.4 | 0.0 | -0.3 | 0.1 | -0.1 | 0.1 | 0.3 | 0.0 | -0.2 | 0.3 | -0.2 | -0.3 |
Delay disc. indifference point, 8s delay | 0.1 | 0.1 | 0.5 | -0.3 | -0.4 | -0.3 | 0.3 | -0.7 | 0.4 | -0.2 | 0.3 | -0.2 | -0.4 | -0.3 | -0.3 | -0.4 | -0.4 | -0.3 |
Food seeking constrained by brief footshock | 0.1 | 0.1 | 0.2 | 0.1 | 0.3 | 0.4 | -0.4 | 0.2 | -0.4 | 0.3 | -0.3 | 0.3 | 0.4 | 0.3 | -0.3 | 0.2 | 0.1 | -0.1 |
Zn content in liver | 0.1 | 0.1 | 0.6 | -0.5 | -0.8 | 0.2 | -0.2 | 0.2 | 0.1 | -0.0 | -0.1 | -0.0 | -0.2 | 0.3 | 0.2 | -0.4 | 0.6 | 0.4 |
Delay discounting water rate 24 sec | 0.0 | 0.0 | 0.2 | 0.2 | 0.4 | -0.2 | 0.2 | 0.3 | -0.1 | 0.2 | -0.2 | 0.2 | 0.3 | 0.1 | -0.0 | 0.1 | -0.0 | 0.1 |
Condit. Reinf. lever presses | 0.0 | 0.1 | 0.2 | 0.1 | 0.3 | -0.1 | 0.1 | -0.4 | 0.2 | 0.0 | 0.1 | -0.0 | 0.1 | 0.1 | -0.5 | 0.3 | -0.3 | -0.4 |
Pavlov. Cond. index score | 0.0 | 0.0 | 0.2 | 0.1 | 0.1 | -0.1 | 0.1 | -0.3 | 0.2 | -0.1 | 0.1 | -0.1 | -0.0 | -0.0 | -0.4 | 0.2 | -0.3 | -0.5 |
Pavlov. Cond. latency score | 0.0 | 0.0 | 0.2 | -0.0 | 0.2 | 0.1 | -0.1 | -0.1 | -0.0 | 0.2 | -0.1 | 0.1 | 0.2 | 0.2 | -0.5 | 0.1 | -0.1 | -0.3 |
Pavlov. Cond. lever-magazine prob. diff. | 0.0 | 0.0 | 0.2 | 0.1 | 0.2 | -0.1 | 0.1 | -0.2 | 0.1 | -0.0 | 0.1 | -0.0 | 0.1 | 0.1 | -0.3 | 0.2 | -0.2 | -0.4 |
Intermittent access terminal intake (last 3 days) | 0.0 | 0.0 | 0.1 | 0.1 | 0.2 | 0.0 | -0.0 | 0.0 | 0.2 | 0.0 | 0.0 | -0.0 | 0.2 | 0.2 | -0.2 | 0.3 | -0.0 | -0.2 |
Lifetime Intake | 0.0 | 0.0 | 0.2 | 0.1 | 0.1 | -0.2 | 0.2 | 0.1 | 0.3 | -0.0 | 0.0 | -0.1 | 0.1 | 0.3 | -0.0 | 0.5 | 0.1 | -0.1 |
Progressive ratio test 1 active lever presses | 0.0 | 0.0 | 0.2 | -0.1 | -0.2 | -0.3 | 0.3 | -0.2 | 0.4 | -0.2 | 0.2 | -0.2 | -0.2 | 0.1 | -0.1 | 0.2 | -0.0 | -0.1 |
Progressive ratio test 1 breakpoint | 0.0 | 0.0 | 0.1 | -0.2 | -0.3 | -0.1 | 0.1 | -0.1 | 0.2 | 0.0 | -0.0 | -0.0 | -0.0 | 0.2 | -0.2 | 0.0 | 0.2 | 0.1 |
Progressive ratio test 2 inactive lever presses | 0.0 | 0.1 | 0.3 | -0.2 | -0.3 | -0.1 | 0.1 | -0.5 | 0.4 | -0.2 | 0.2 | -0.2 | -0.2 | 0.1 | -0.2 | 0.0 | -0.1 | -0.2 |
Total sessions with >9 infusions | 0.0 | 0.0 | 0.1 | -0.0 | -0.2 | -0.0 | 0.0 | 0.3 | 0.3 | -0.1 | 0.1 | -0.1 | 0.0 | 0.3 | 0.2 | 0.4 | 0.3 | 0.2 |
Short access day 10 total infusions | 0.0 | 0.0 | 0.1 | -0.3 | -0.3 | 0.2 | -0.2 | -0.0 | -0.0 | 0.1 | -0.1 | 0.1 | 0.0 | 0.3 | -0.2 | -0.1 | 0.2 | 0.2 |
Bone surface | 0.0 | 0.0 | 0.1 | -0.1 | -0.2 | -0.2 | 0.2 | -0.1 | 0.1 | -0.1 | 0.0 | -0.0 | -0.1 | -0.1 | 0.1 | -0.3 | 0.1 | 0.1 |
Locomotion in novel chamber | 0.0 | 0.1 | 0.1 | -0.1 | 0.1 | 0.3 | -0.3 | 0.1 | -0.4 | 0.3 | -0.2 | 0.3 | 0.3 | 0.2 | -0.3 | -0.1 | 0.1 | 0.1 |
Latency to leave start box in cocaine runway, M | 0.0 | 0.0 | 0.1 | -0.1 | -0.2 | 0.2 | -0.2 | -0.0 | -0.1 | 0.1 | -0.1 | 0.1 | -0.1 | -0.0 | 0.0 | -0.3 | 0.1 | 0.2 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.