Best TWAS P=5.85e-11 · Best GWAS P=3.34e-10 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Cdc23 | alternative polyA | NM_001100659.1 | 0.17 | 868 | 0.13 | 1.3e-14 | -5.94 | 2.81e-09 | 0.66 | FALSE |
| Adipose | Cdc23 | alternative polyA | XM_008772028.3 | 0.06 | 1 | 0.04 | 6.2e-05 | -6.05 | 1.46e-09 | 0.33 | FALSE |
| Adipose | Cdc23 | alternative polyA | XM_039096724.1 | 0.11 | 868 | 0.08 | 2.1e-09 | 5.73 | 1.02e-08 | 0.66 | FALSE |
| Adipose | Cdc23 | alternative polyA | NM_001100659.1 | 0.1 | 1 | 0.08 | 7.4e-09 | -6.05 | 1.46e-09 | 0.66 | FALSE |
| Adipose | Cdc23 | alternative polyA | XM_008772028.3 | 0.1 | 1 | 0.08 | 8.3e-09 | 6.05 | 1.46e-09 | 0.66 | FALSE |
| Adipose | Brd8 | gene expression | Brd8 | 0.04 | 1 | 0.01 | 9.8e-03 | -6.22 | 4.94e-10 | 0.06 | FALSE |
| Adipose | Fam13b | gene expression | Fam13b | 0.15 | 1 | 0.17 | 1.0e-18 | -5.49 | 4.04e-08 | 0.05 | FALSE |
| Adipose | Kif20a | gene expression | Kif20a | 0.02 | 1 | 0.02 | 3.9e-03 | -6.01 | 1.80e-09 | 0.04 | FALSE |
| Adipose | Pkd2l2 | gene expression | Pkd2l2 | 0.03 | 1 | 0.04 | 1.8e-05 | 6.01 | 1.80e-09 | 0.14 | FALSE |
| Adipose | Reep5 | gene expression | Reep5 | 0.05 | 1 | 0.06 | 3.0e-07 | 5.22 | 1.83e-07 | 0.01 | FALSE |
| Adipose | Srp19 | gene expression | Srp19 | 0.05 | 1 | 0.03 | 3.0e-04 | -6.05 | 1.46e-09 | 0.1 | FALSE |
| Adipose | Cdc23 | isoform ratio | NM_001100659.1 | 0.14 | 868 | 0.11 | 1.6e-12 | -5.94 | 2.85e-09 | 0.66 | FALSE |
| Adipose | Cdc23 | isoform ratio | XM_008772028.3 | 0.13 | 868 | 0.1 | 5.1e-11 | 5.89 | 3.89e-09 | 0.66 | FALSE |
| Adipose | Fam13b | mRNA stability | Fam13b | 0.13 | 1015 | 0.16 | 6.5e-17 | 5.63 | 1.76e-08 | 0.61 | FALSE |
| BLA | LOC120098271 | gene expression | LOC120098271 | 0.05 | 1 | 0.03 | 7.0e-03 | 5.49 | 4.04e-08 | 0.04 | FALSE |
| BLA | Apc | intron excision ratio | chr18_25903143_25907713 | 0.05 | 1 | 0.05 | 1.0e-03 | 5.49 | 4.04e-08 | 0.04 | FALSE |
| BLA | Reep5 | intron excision ratio | chr18_25947663_25949991 | 0.07 | 1 | 0.06 | 4.9e-04 | 5.82 | 5.81e-09 | 0.04 | FALSE |
| Brain | Cdc23 | alternative polyA | NM_001100659.1 | 0.14 | 9 | 0.1 | 6.6e-10 | -5.72 | 1.05e-08 | 0.66 | FALSE |
| Brain | Cdc23 | alternative polyA | NM_001100659.1 | 0.09 | 1 | 0.08 | 5.7e-08 | 5.8 | 6.62e-09 | 0.23 | FALSE |
| Brain | Cdc23 | alternative polyA | XM_008772028.3 | 0.09 | 1 | 0.08 | 5.9e-08 | -5.8 | 6.62e-09 | 0.23 | FALSE |
| Brain | Fam13b | alternative TSS | XM_039096734.1 | 0.07 | 1015 | 0.09 | 8.4e-09 | 5.39 | 7.06e-08 | 0.69 | FALSE |
| Brain | Brd8 | gene expression | Brd8 | 0.03 | 1 | 0.05 | 1.7e-05 | -5.2 | 2.00e-07 | 0.03 | FALSE |
| Brain | Cdc23 | gene expression | Cdc23 | 0.03 | 1 | 0.02 | 3.6e-03 | -6.1 | 1.06e-09 | 0.06 | FALSE |
| Brain | LOC103694952 | gene expression | LOC103694952 | 0.03 | 1178 | 0.03 | 2.0e-03 | 5.3 | 1.15e-07 | 0.52 | FALSE |
| Brain | Reep5 | gene expression | Reep5 | 0.05 | 1129 | 0.05 | 8.5e-06 | 6.23 | 4.52e-10 | 0.7 | FALSE |
| Brain | Cdc23 | isoform ratio | NM_001100659.1 | 0.09 | 1 | 0.09 | 4.7e-09 | 6.2 | 5.74e-10 | 0.76 | FALSE |
| Brain | Cdc23 | isoform ratio | XM_008772028.3 | 0.07 | 869 | 0.08 | 1.3e-07 | 6 | 2.01e-09 | 0.7 | FALSE |
| Brain | Fam13b | isoform ratio | XM_039096734.1 | 0.08 | 1 | 0.11 | 2.7e-10 | -6.05 | 1.46e-09 | 0.56 | FALSE |
| Brain | Apc | intron excision ratio | chr18_25864409_25871423 | 0.07 | 1 | 0.02 | 1.1e-02 | -6.19 | 5.91e-10 | 0.05 | FALSE |
| Brain | Cdc23 | intron excision ratio | chr18_26240165_26240396 | 0.03 | 1 | 0.03 | 1.6e-03 | 5.82 | 5.81e-09 | 0.04 | FALSE |
| Brain | Kif20a | mRNA stability | Kif20a | 0.05 | 915 | 0.05 | 8.2e-06 | -5.77 | 7.90e-09 | 0.57 | FALSE |
| Eye | Fam13b | gene expression | Fam13b | 0.73 | 342 | 0.27 | 4.6e-05 | -5.47 | 4.53e-08 | 0.36 | FALSE |
| Eye | Srp19 | intron excision ratio | chr18_25935986_25936079 | 0.23 | 1 | 0.1 | 1.5e-02 | -5.22 | 1.76e-07 | 0.06 | FALSE |
| IL | Cdc23 | isoform ratio | NM_001100659.1 | 0.21 | 869 | 0.05 | 2.4e-02 | -5.99 | 2.04e-09 | 0.32 | FALSE |
| LHb | Cdc23 | gene expression | Cdc23 | 0.3 | 4 | 0.15 | 2.4e-04 | 6.19 | 5.92e-10 | 0.61 | FALSE |
| LHb | Cdc23 | isoform ratio | XM_008772028.3 | 0.31 | 1 | 0.16 | 1.2e-04 | -6.05 | 1.49e-09 | 0.07 | FALSE |
| Liver | Brd8 | gene expression | Brd8 | 0.07 | 99 | 0.05 | 5.7e-06 | -5.64 | 1.71e-08 | 0.64 | FALSE |
| Liver | Fam13b | gene expression | Fam13b | 0.17 | 1015 | 0.15 | 1.2e-16 | 6.4 | 1.56e-10 | 0.61 | FALSE |
| Liver | Pkd2l2 | gene expression | Pkd2l2 | 0.03 | 1 | 0.04 | 4.5e-05 | -6.05 | 1.46e-09 | 0.08 | FALSE |
| Liver | Srp19 | gene expression | Srp19 | 0.05 | 1 | 0.02 | 3.2e-03 | -5.47 | 4.46e-08 | 0.03 | FALSE |
| Liver | Cdc23 | isoform ratio | NM_001100659.1 | 0.08 | 868 | 0.04 | 2.0e-05 | -5.94 | 2.85e-09 | 0.66 | FALSE |
| Liver | Cdc23 | isoform ratio | XM_008772028.3 | 0.15 | 868 | 0.11 | 2.3e-12 | 5.95 | 2.76e-09 | 0.66 | FALSE |
| Liver | Srp19 | intron excision ratio | chr18_25931783_25935915 | 0.03 | 1 | 0.03 | 4.2e-04 | 5.22 | 1.76e-07 | 0.03 | FALSE |
| NAcc | Cdc23 | alternative polyA | NM_001100659.1 | 0.1 | 869 | 0.09 | 5.0e-10 | -6.17 | 6.88e-10 | 0.71 | FALSE |
| NAcc | Cdc23 | alternative polyA | NM_001100659.1 | 0.12 | 59 | 0.09 | 1.6e-10 | 5.22 | 1.78e-07 | 0.68 | FALSE |
| NAcc | Cdc23 | alternative polyA | XM_008772028.3 | 0.13 | 91 | 0.09 | 7.1e-11 | -5.23 | 1.70e-07 | 0.68 | FALSE |
| NAcc | Epb41l4a | gene expression | Epb41l4a | 0.11 | 1049 | 0.04 | 1.9e-05 | 6.02 | 1.72e-09 | 0.53 | FALSE |
| NAcc | Reep5 | gene expression | Reep5 | 0.04 | 1129 | 0.05 | 1.1e-06 | 5.81 | 6.26e-09 | 0.61 | FALSE |
| NAcc | Cdc23 | isoform ratio | NM_001100659.1 | 0.41 | 869 | 0.11 | 3.2e-13 | -6.55 | 5.85e-11 | 0.72 | TRUE |
| NAcc | Cdc23 | isoform ratio | XM_008772028.3 | 0.08 | 17 | 0.07 | 5.1e-09 | 5.76 | 8.17e-09 | 0.7 | FALSE |
| PL | Cdc23 | alternative polyA | NM_001100659.1 | 0.08 | 1 | 0.07 | 2.9e-08 | 6.24 | 4.40e-10 | 0.8 | FALSE |
| PL | Cdc23 | alternative polyA | NM_001100659.1 | 0.04 | 1 | 0.03 | 2.5e-04 | 6.23 | 4.70e-10 | 0.21 | FALSE |
| PL | Cdc23 | alternative polyA | XM_008772028.3 | 0.04 | 1 | 0.03 | 2.5e-04 | -6.23 | 4.70e-10 | 0.17 | FALSE |
| PL | Fam13b | alternative TSS | XM_039096734.1 | 0.03 | 1015 | 0.03 | 5.9e-04 | 5.23 | 1.74e-07 | 0.66 | FALSE |
| PL | Brd8 | gene expression | Brd8 | 0.03 | 1 | 0.02 | 1.5e-03 | -5.49 | 4.04e-08 | 0.03 | FALSE |
| PL | LOC120098271 | gene expression | LOC120098271 | 0.03 | 1199 | 0.02 | 1.5e-03 | -5.6 | 2.11e-08 | 0.65 | FALSE |
| PL | Reep5 | gene expression | Reep5 | 0.04 | 1129 | 0.02 | 3.2e-03 | 6.51 | 7.29e-11 | 0.5 | FALSE |
| PL | Srp19 | gene expression | Srp19 | 0.02 | 1244 | 0.01 | 4.3e-02 | -6.03 | 1.60e-09 | 0.49 | FALSE |
| PL | Cdc23 | isoform ratio | NM_001100659.1 | 0.07 | 31 | 0.06 | 1.2e-07 | 5.81 | 6.32e-09 | 0.71 | FALSE |
| PL | Cdc23 | isoform ratio | XM_008772028.3 | 0.1 | 1 | 0.08 | 1.7e-09 | -5.65 | 1.60e-08 | 0.11 | FALSE |
| PL | Fam13b | isoform ratio | XM_039096734.1 | 0.02 | 1 | 0.02 | 2.7e-03 | -5.49 | 4.04e-08 | 0.03 | FALSE |
| PL | Apc | intron excision ratio | chr18_25864409_25871423 | 0.03 | 1 | 0.02 | 1.2e-03 | -5.22 | 1.76e-07 | 0.03 | FALSE |
| PL | Cdc23 | intron excision ratio | chr18_26240669_26242295 | 0.05 | 1 | 0.04 | 5.3e-05 | -6.24 | 4.39e-10 | 0.41 | FALSE |
| PL | Nme5 | intron excision ratio | chr18_26169875_26180166 | 0.07 | 1 | 0.04 | 1.3e-05 | -6.26 | 3.83e-10 | 0.62 | FALSE |
| pVTA | Cdc23 | alternative polyA | XM_039096724.1 | 0.11 | 1 | 0.03 | 2.3e-02 | -5.98 | 2.20e-09 | 0.05 | FALSE |
| pVTA | Brd8 | gene expression | Brd8 | 0.11 | 1 | 0.09 | 1.6e-04 | -6.22 | 5.10e-10 | 0.09 | FALSE |
| pVTA | Cdc23 | gene expression | Cdc23 | 0.07 | 100 | 0.08 | 2.2e-04 | -5.24 | 1.64e-07 | 0.62 | FALSE |
| pVTA | Nme5 | gene expression | Nme5 | 0.08 | 923 | 0.03 | 1.6e-02 | -5.92 | 3.17e-09 | 0.47 | FALSE |
| pVTA | Cdc23 | isoform ratio | XM_008772028.3 | 0.3 | 869 | 0.29 | 4.7e-13 | 6.06 | 1.40e-09 | 0.72 | FALSE |
| RMTg | Srp19 | gene expression | Srp19 | 0.09 | 100 | 0.06 | 1.0e-02 | -5.6 | 2.16e-08 | 0.46 | FALSE |
| RMTg | Nme5 | intron excision ratio | chr18_26164061_26169757 | 0.09 | 1 | 0.07 | 7.4e-03 | -6.24 | 4.45e-10 | 0.06 | FALSE |
| RMTg | Nme5 | intron excision ratio | chr18_26169875_26180166 | 0.12 | 923 | 0.12 | 4.0e-04 | 5.89 | 3.95e-09 | 0.59 | FALSE |