Hub : Genes

Nrap

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000016714	0.04	0.03	1.2e-05	0.03	0.05	0.03	0.05	3.1e-04	2.5e-06	9.7e-05	5.5e-06
2	Brain	mRNA stability	ENSRNOG00000016714	0.04	0.03	5.8e-04	0.04	0.03	0.02	0.03	1.5e-04	1.4e-03	6.8e-03	5.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	8.7	28.2	30.3	5.5	-5.1
BMI without tail	4.1	8.7	9.6	2.8	-3.1
Body weight	9.8	41.6	42.9	6.5	-6.3
Epididymis fat weight	16.5	38.6	45.6	5.6	-6.7
Glucose	7.0	10.7	12.6	3.0	-3.5
Heart weight	3.7	5.3	5.5	2.3	-2.3
Left kidney weight	4.2	11.9	15.2	3.9	-2.9
Right kidney weight	6.8	19.4	24.0	4.9	-3.8
Tail length	0.6	1.8	3.3	0.5	-1.8
Length with tail	2.8	10.4	11.3	3.1	-3.4
Length without tail	5.7	12.5	14.3	3.8	-3.3
Liver weight, left	3.9	6.4	7.5	2.3	-2.7
Liver weight, right	8.7	14.4	15.8	3.6	-4.0
Parametrial fat weight	8.5	16.6	22.0	3.4	-4.7
Retroperitoneal fat weight	14.7	48.6	55.3	6.5	-7.4
Intraocular pressure	3.1	4.3	4.4	2.1	-2.1
Extensor digitorum longus weight	0.1	0.4	0.6	0.8	-0.5
Soleus weight	5.2	15.1	16.0	3.8	-4.0
Tibialis anterior weight	0.1	0.2	0.3	-0.3	0.5
Tibia length	2.3	6.4	7.7	2.8	-2.3
Number of licking bursts	0.4	0.4	0.8	0.2	-0.9
Food consumed during 24 hour testing period	0.0	0.0	0.0	-0.0	0.0
Times rat made contact with spout	0.5	0.6	0.8	0.9	-0.6
Mean time between licks in bursts	0.0	0.1	0.1	-0.3	-0.1
Mean num. licks in bursts	0.3	0.4	0.7	0.8	0.1
Std. dev. time between licks in bursts	0.4	0.5	0.8	-0.9	0.5
Water consumed over 24 hours	0.6	0.7	0.9	1.0	-0.7
Indifference point 0 sec	3.5	5.7	6.6	2.2	-2.6
Indifference point AUC	0.0	0.0	0.0	-0.1	-0.0
Indifference point function ln k	0.1	0.1	0.1	0.4	-0.2
Indifference point function log k	0.1	0.1	0.1	0.4	-0.2
Delay discounting total patch changes 0 sec	3.3	5.3	6.5	2.0	-2.5
Delay discounting total patch changes 12 sec	0.4	0.5	0.9	0.4	-0.9
Delay discounting total patch changes 18 sec	1.4	1.9	2.6	1.1	-1.6
Delay discounting total patch changes 24 sec	0.8	1.0	1.5	0.6	-1.2
Delay discounting total patch changes 6 sec	3.8	5.8	6.5	2.3	-2.5
Delay discounting time to switch 0 sec	0.3	0.4	0.5	-0.7	0.6
Delay discounting water rate 0 sec	0.6	1.0	1.0	1.0	-1.0
Delay discounting water rate 12 sec	0.5	0.8	1.0	0.8	-1.0
Delay discounting water rate 18 sec	0.8	1.0	1.5	1.2	-0.8
Delay discounting water rate 24 sec	1.7	2.4	2.4	1.6	-1.5
Delay discounting water rate 6 sec	0.6	0.9	1.0	1.0	-0.8
Locomotor activity	2.6	4.1	4.6	1.9	-2.1
Locomotor testing distance	3.4	5.6	5.7	2.4	-2.4
Locomotor testing rearing	1.7	2.6	2.7	1.6	-1.6
Light reinforcement 1	1.4	2.6	2.9	-1.7	1.5
Light reinforcement 2	2.0	2.6	2.9	-1.7	1.5
Reaction time number correct	0.4	0.6	0.6	0.8	-0.8
Reaction time mean minus median	0.8	1.0	1.2	1.1	-0.9
Reaction time mean minus median AUC	1.1	1.4	1.7	1.3	-1.1
Reaction time num false alarms	0.0	0.0	0.0	-0.2	0.0
Reaction time num false alarms AUC	0.0	0.1	0.1	0.1	-0.3
Reaction time trials correct on left	0.4	0.6	0.6	0.8	-0.8
Reaction time trials on left	0.5	0.7	0.7	0.8	-0.8
Reaction time mean	0.9	1.2	1.5	1.0	-1.2
Reaction time mean AUC	0.3	0.4	0.5	0.5	-0.7
Median of all reaction times	0.7	1.0	1.2	0.9	-1.1
Reaction time omissions	0.1	0.2	0.3	0.5	-0.3
Reaction time false alarm rate	0.1	0.1	0.2	-0.5	0.2
Reaction time premature initiation rate	0.9	1.2	1.5	1.2	-1.0
Reaction time premature initiations	2.0	2.9	3.3	1.8	-1.6
Std. dev. reaction times	2.6	3.6	3.8	1.9	-1.9
Reaction time trials completed	0.5	0.7	0.7	0.8	-0.8
Reaction time trials AUC	0.5	0.7	0.8	0.9	-0.8
Social response proportion	3.2	3.5	5.3	2.3	-1.3
Social responses	5.6	7.2	7.3	2.7	-2.7
Social time	2.9	3.8	3.9	1.9	-2.0
Conditioned locomotion	0.0	0.0	0.0	-0.2	-0.0
Cocaine response after cond. corrected	1.5	1.7	2.7	-0.9	1.6
Cocaine response after cond. not corrected	2.2	2.5	3.3	-1.3	1.8
Cocaine response before conditioning	0.3	0.3	0.7	-0.8	0.0
Saline control response	0.0	0.0	0.1	0.3	0.1
Condit. Reinf. active minus inactive responses	0.4	0.6	0.8	0.5	-0.9
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.1	-0.1
Condit. Reinf. active responses	1.6	2.2	2.9	1.2	-1.7
Condit. Reinf. inactive responses	1.1	1.4	1.8	1.0	-1.3
Condit. Reinf. lever presses	0.2	0.3	0.6	0.2	-0.8
Condit. Reinf. lever reinforcers received	1.0	1.3	1.8	1.0	-1.3
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.1	0.4
Pavlov. Cond. magazine entry latency	1.2	1.3	2.1	0.7	-1.4
Pavlov. Cond. change in total contacts	0.5	0.7	1.1	0.5	-1.0
Pavlov. Cond. index score	1.0	1.3	2.0	0.8	-1.4
Pavlov. Cond. latency score	1.0	1.2	1.9	0.7	-1.4
Pavlov. Cond. lever contacts	0.4	0.6	1.1	0.3	-1.0
Pavlov. Cond. magazine entry number	0.8	1.0	1.5	-0.8	1.2
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	0.2	0.0
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.5	2.1	0.9	-1.5
Pavlov. Cond. response bias	0.9	1.2	2.1	0.6	-1.4
Conditioned reinforcement - actives	0.0	0.0	0.1	0.1	0.3
Conditioned reinforcement - inactives	0.8	0.9	1.0	0.8	-1.0
Conditioned locomotion	0.1	0.2	0.3	-0.1	0.6
Intermittent access intake day 1-15 change	3.8	3.7	4.6	1.7	-2.1
Intermittent access intake escalation	6.0	6.0	6.3	2.4	-2.5
Intermittent access intake escalation 2	3.1	3.1	3.2	1.7	-1.8
Intermitt. access day 1 inactive lever presses	1.7	1.9	2.9	0.9	-1.7
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.2	0.4	-0.4
Intermitt. access escalation Index	0.1	0.1	0.2	0.1	-0.4
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.1	-0.2
Intermittent access day 15 total infusions	1.9	2.1	2.6	1.3	-1.6
Intermittent access terminal intake (last 3 days)	0.9	0.9	1.2	0.8	-1.1
Intermittent access total infusions	0.9	1.0	1.0	1.0	-1.0
Intermittent access day 1 locomotion	0.0	0.0	0.0	0.1	0.1
Intermittent access day 15 total locomotion	3.1	3.3	3.4	1.8	-1.9
Intermittent access total locomotion	0.7	0.7	1.1	1.0	-0.6
Intermittent access standard deviation	0.8	0.9	1.6	0.4	-1.3
Cocaine induced anxiety	4.7	5.4	6.1	-2.2	2.5
Post-drug Anxiety	0.7	0.8	0.9	-0.8	0.9
Baseline Anxiety	6.5	6.9	8.2	2.4	-2.9
Lifetime Intake	1.1	1.2	1.2	1.1	-1.1
Incentive Sensitization - Responses	1.8	1.8	1.9	1.4	-1.3
Incentive Sensitization - Breakpoint	1.8	1.8	1.9	1.4	-1.3
Progressive ratio test 1 active lever presses	1.2	1.3	1.5	1.2	-1.0
Progressive ratio test 1 breakpoint	0.5	0.5	0.5	0.7	-0.7
Progressive ratio test 1 inactive lever presses	0.4	0.4	0.6	0.4	-0.7
Progressive ratio test 2 active lever presses	3.0	3.2	3.6	1.9	-1.6
Progressive ratio test 2 breakpoint	2.5	2.8	3.1	1.8	-1.6
Progressive ratio test 2 inactive lever presses	1.0	1.1	1.3	1.0	-1.1
Total sessions with >9 infusions	6.9	7.6	8.8	3.0	-2.5
Short access day 1 total inactive lever presses	0.7	0.8	1.1	0.7	-1.0
Short access day 10 total inactive lever presses	0.9	1.0	1.4	0.8	-1.2
Short access day 1 total infusions	1.0	1.1	1.1	1.1	-1.0
Short access day 10 total infusions	0.1	0.1	0.2	0.4	-0.2
Short access total infusions	0.6	0.6	0.7	0.9	-0.7
Short access day 1 locomotion	0.7	0.8	0.8	0.9	-0.9
Short access day 10 total locomotion	1.0	1.1	1.3	1.1	-0.9
Short access total locomotion	1.2	1.2	1.6	1.3	-0.9
Compulsive drug intake	0.5	0.5	0.6	-0.8	0.7
One hour access (0.3 mA shock)	1.6	1.8	2.7	1.0	-1.6
One hour access (shock baseline)	2.9	3.3	4.0	1.6	-2.0
Number of responses in last shaping day	0.1	0.1	0.1	0.3	-0.3
Context. condit. distance diff. score	0.6	0.8	0.8	-0.8	0.9
Locomotion velocity, session 1	0.6	0.6	0.7	-0.7	0.9
Locomotion distance, session 1	0.3	0.4	0.5	0.6	0.7
Locomotion velocity, session 2	0.2	0.2	0.3	0.5	0.3
Locomotion distance, session 2	1.4	2.1	2.5	1.6	-1.3
Locomotion velocity, session 3	0.2	0.2	0.5	0.7	0.1
Locomotion distance, session 3	0.3	0.3	0.6	0.8	-0.2
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	0.2	-0.5
Stereotopy head waving duration, day 3	0.1	0.2	0.3	-0.6	0.1
Locomotion velocity, session 7	0.1	0.1	0.1	0.3	-0.3
Locomotion distance, session 7	0.0	0.0	0.0	-0.1	0.1
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	0.0	-0.5
Stereotopy head waving duration, day 7	0.7	0.8	1.2	0.7	-1.1
Locomotion velocity, session 8	2.8	3.3	4.3	-1.6	2.1
Locomotion distance, session 8	0.3	0.4	0.8	-0.4	0.9
Degree of sensitization distance	1.2	1.2	2.0	-1.4	0.6
Degree of sensitization stereotypy	0.1	0.1	0.1	-0.1	-0.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.1	0.4
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.6	-0.1	0.8
Condit. Reinf. active responses	0.4	0.5	0.7	0.8	-0.5
Condit. Reinf. inactive responses	1.0	1.2	1.3	1.0	-1.1
Incentive salience index mean	0.3	0.4	0.7	-0.1	0.8
Condit. Reinf. lever presses	0.3	0.4	0.9	-0.1	0.9
Time in familiar zone, hab. session 1	0.2	0.2	0.4	0.2	0.7
Time in novel zone, hab. session 1	0.7	0.7	1.4	0.3	-1.2
Total zone transitions, hab. session 1	2.1	3.0	3.1	1.7	-1.8
Total locomotion distance, hab. session 1	0.2	0.3	0.6	-0.0	-0.8
Locomotion velocity, hab. session 1	0.1	0.1	0.2	-0.2	-0.5
Time in familiar zone, hab. session 2	0.3	0.4	0.4	0.5	-0.6
Time in novel zone, hab. session 2	0.0	0.0	0.0	0.2	0.1
Total zone transitions, hab. session 2	2.2	2.8	3.1	1.8	-1.6
Total locomotion distance, hab. session 2	0.8	1.1	1.3	1.0	-1.2
Locomotion velocity, hab. session 2	0.6	0.8	1.1	0.8	-1.0
Novel to familiar place preference ratio	0.1	0.1	0.1	-0.3	-0.3
Novelty place preference	0.1	0.1	0.3	-0.1	-0.5
Time in novel zone, NPP test	0.3	0.4	0.7	0.1	-0.8
Total zone transitions, NPP test	0.7	1.0	1.2	1.1	-0.8
Total locomotion distance, NPP test	0.3	0.4	0.6	0.5	-0.7
Locomotion velocity, NPP test	0.1	0.1	0.1	0.3	-0.3
Pavlov. Cond. lever latency	0.0	0.1	0.1	-0.1	-0.3
Pavlov. Cond. magazine entry latency	0.3	0.4	0.5	0.6	-0.7
Pavlov. Cond. change in total contacts	0.0	0.1	0.1	0.3	0.2
Pavlov. Cond. index score	0.3	0.4	0.5	0.7	-0.6
Pavlov. Cond. latency score	0.2	0.2	0.3	0.6	-0.4
Pavlov. Cond. lever contacts	0.0	0.0	0.0	0.1	0.2
Pavlov. Cond. magazine entry number	1.4	1.8	1.9	-1.4	1.3
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.4	-0.0
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.3	0.6	-0.5
Pavlov. Cond. response bias	0.4	0.5	0.6	0.8	-0.7
Bone: apparent density	0.5	0.7	1.1	1.0	-0.7
Bone surface	0.3	0.5	0.7	0.8	-0.6
Bone volume	1.5	2.6	3.1	1.8	-1.4
Bone: connectivity density	0.1	0.2	0.3	-0.3	0.6
Bone: cortical apparent density	0.2	0.3	0.4	0.6	0.4
Bone: cortical area	9.9	15.0	15.1	3.9	-3.9
Bone: cortical porosity	0.0	0.0	0.0	-0.2	0.2
Bone: cortical porosity	0.0	0.0	0.0	-0.1	-0.1
Bone: cortical thickness	5.7	9.4	9.8	3.1	-3.0
Bone: cortical thickness	3.0	3.5	3.8	2.0	-1.8
Bone: cortical tissue density	0.2	0.2	0.3	0.4	0.6
Bone: elastic displacement	0.1	0.1	0.2	-0.4	0.1
Bone: elastic work	1.3	1.7	2.3	1.5	-1.1
Bone: endosteal estimation	1.5	3.2	3.6	1.7	-1.9
Bone: endosteal perimeter	5.8	11.8	12.0	3.4	-3.5
Bone: final force	3.0	4.9	6.4	2.5	-1.8
Bone: final moment	3.1	5.1	6.6	2.6	-1.9
Bone: marrow area	1.6	3.4	3.7	1.7	-1.9
Bone: maximum diameter	8.3	15.1	16.7	3.7	-4.1
Bone: maximum force	3.1	5.4	6.7	2.6	-2.0
Bone: maximum moment	3.2	5.5	6.6	2.6	-2.1
Bone: minimum diameter	3.9	7.2	8.8	2.4	-3.0
Bone: periosteal estimation	6.0	12.2	12.4	3.5	-3.5
Bone: periosteal perimeter	11.4	18.9	19.4	4.4	-4.3
Bone: post-yield work	0.0	0.1	0.1	-0.3	0.1
Bone: stiffness	2.2	3.5	4.3	2.1	-1.6
Bone: tissue strength	0.3	0.3	0.4	-0.7	0.5
Bone: trabecular number	0.1	0.1	0.2	0.1	0.5
Bone: trabecular spacing	0.1	0.1	0.1	-0.3	-0.3
Bone: trabecular thickness	4.8	5.8	7.0	2.1	-2.6
Bone: trabecular tissue density	0.8	1.1	1.9	1.4	-0.6
Breakpoint value in progressive ratio session	0.2	0.2	0.3	-0.5	-0.3
Distance traveled before self-admin	0.0	0.0	0.1	0.0	0.3
Distance traveled after self-admin	0.4	0.5	0.8	0.9	-0.5
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.0	-0.0
Delta time in open arm before/after self-admin	0.2	0.2	0.3	0.1	-0.6
Diff in mean of infusions in LGA sessions	4.3	4.8	5.5	-2.3	2.0
Extinction: sum of active levers before priming	0.7	0.7	1.3	-1.1	0.4
Active lever presses in extinction session 6	0.5	0.5	0.8	0.4	-0.9
Delta distance traveled before/after self-admin	1.0	1.1	1.1	1.1	-1.0
Delta ambulatory time before/after self-admin	0.7	0.8	1.0	0.8	-1.0
Time in closed arm before self-admin	0.0	0.0	0.1	0.3	0.1
Time in closed arm after self-admin	0.2	0.2	0.2	-0.4	0.5
Time in open arm before self-admin	1.8	1.9	2.4	-1.5	1.2
Time in open arm after self-admin	0.5	0.6	0.9	-1.0	0.5
Sum of active levers in priming session hrs 5-6	2.4	2.4	2.8	-1.7	1.4
Time to tail flick, vehicle, before self-admin	2.5	2.6	3.3	1.3	-1.8
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.4	0.6	-0.0
Time to tail flick, test, before self-admin	1.5	1.5	2.6	1.6	-0.7
Time to tail flick, test, after self-admin	3.0	3.1	3.9	1.5	-2.0
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.1	0.4
Delta time to tail flick, test, before/after SA	1.8	1.6	2.5	0.8	-1.6
Ambulatory time before self-admin	0.5	0.5	0.5	0.7	-0.7
Ambulatory time after self-admin	0.7	0.8	1.0	1.0	-0.8
Total heroin consumption	0.6	0.8	1.4	0.4	-1.2
Area under the delay curve	0.7	0.7	1.2	0.5	-1.1
Delay disc. indifference point, 0s delay	1.0	1.1	1.8	0.7	-1.3
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	-0.4	-0.0
Delay disc. indifference point, 2s delay	0.1	0.2	0.3	-0.2	-0.5
Delay disc. indifference point, 24s delay	0.5	0.5	1.0	-0.1	-1.0
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	-0.6	0.1
Delay disc. indifference point, 8s delay	3.3	3.5	3.7	1.8	-1.9
Delay discount exponential model param	0.7	0.8	1.3	-0.5	1.2
Delay discount hyperbolic model param	0.5	0.5	1.0	-0.3	1.0
Fecal boli incidents, locomotor time 1	0.7	0.7	1.0	0.7	-1.0
Change in fecal boli incidents, locomotor task	2.2	2.1	2.6	-1.3	1.6
Time >=10cm from walls, locomotor time 1	3.0	3.0	3.8	-1.5	1.9
Bouts of movement, locomotor time 1	0.4	0.4	0.7	0.3	-0.8
Total resting periods, locomotor time 1	0.4	0.4	0.7	0.4	-0.8
Rest time, locomotor task time 1	0.4	0.4	0.5	0.7	-0.6
Distance moved, locomotor task time 1	0.0	0.0	0.0	-0.1	-0.0
Vertical activity count, locomotor time 1	0.6	0.6	1.0	-0.5	1.0
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.1	-0.2	-0.2
Bouts of movement, locomotor time 2	3.1	3.3	3.9	-1.7	2.0
Total resting periods, locomotor time 2	1.9	2.0	2.4	-1.3	1.5
Rest time, locomotor task time 2	0.2	0.2	0.3	0.6	-0.3
Distance moved, locomotor task time 2	0.1	0.2	0.3	0.0	-0.6
Vertical activity count, locomotor time 2	0.1	0.1	0.2	0.2	-0.5
Weight adjusted by age	8.3	9.3	10.0	3.2	-2.9
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.2	-0.4	0.4
Locomotion in novel chamber	0.1	0.1	0.2	0.5	0.1
Locomotion in novel chamber post-restriction	0.6	0.7	1.3	-0.4	1.2
Progressive ratio	0.6	0.7	1.0	-1.0	0.7
Food seeking constrained by brief footshock	1.0	1.3	1.6	-1.2	1.0
Seeking ratio, punishment vs. effort	0.0	0.0	0.0	0.2	-0.1
Run reversals in cocaine runway, females	0.9	0.9	1.5	1.2	-0.5
Run reversals in cocaine runway, males	2.5	2.4	3.0	-1.7	1.4
Latency to leave start box in cocaine runway	0.5	0.6	0.7	-0.8	0.7
Latency to leave start box in cocaine runway, F	0.8	0.9	1.0	-0.9	1.0
Latency to leave start box in cocaine runway, M	0.2	0.2	0.3	0.3	-0.6
Cd content in liver	3.9	4.3	4.7	-2.0	2.2
Co content in liver	0.4	0.5	1.0	-0.1	1.0
Cu content in liver	0.2	0.2	0.3	0.5	0.4
Fe content in liver	0.0	0.0	0.1	-0.1	-0.2
K content in liver	0.9	0.9	0.9	-0.9	1.0
Mg content in liver	0.4	0.4	0.5	-0.7	0.6
Mn content in liver	0.7	0.8	1.1	-1.0	0.8
Na content in liver	0.9	0.9	1.2	-1.1	0.8
Rb content in liver	1.8	2.2	3.9	-2.0	0.8
Se content in liver	0.3	0.4	0.5	-0.6	0.7
Sr content in liver	2.4	2.2	2.8	-1.2	1.7
Zn content in liver	3.0	3.3	4.8	-1.3	2.2