chr2:60,489,445-63,359,968

Trait: Body weight

Best TWAS P = 8.53e-09 · Best GWAS P= 2.01e-08 conditioned to 1.00e+00

Associated models

Tissue	Gene	RNA modality	RNA phenotype	h²	# weights	Model R²	Model R² P	TWAS Z	TWAS P	Coloc P	Joint
Adipose	Adamts12	alternative polyA	NM_001106420.4	0.04	1383	0.03	7.4e-04	5.28	1.32e-07	0.44	FALSE
Adipose	Adamts12	alternative polyA	XM_039101948.2	0.04	1383	0.03	8.0e-04	-5.25	1.52e-07	0.44	FALSE
Adipose	Adamts12	gene expression	Adamts12	0.09	71	0.06	1.6e-07	5.39	6.94e-08	0.46	FALSE
Adipose	Tars1	gene expression	Tars1	0.13	1427	0.16	3.3e-17	5.47	4.54e-08	0.53	FALSE
Adipose	Adamts12	isoform ratio	XM_039101948.2	0.03	1383	0.02	5.3e-03	-5.24	1.60e-07	0.41	FALSE
BLA	Rad1	gene expression	Rad1	0.28	1	0.22	1.2e-11	-5.21	1.90e-07	0.51	FALSE
BLA	Tars1	gene expression	Tars1	0.18	146	0.19	2.0e-10	5.76	8.53e-09	0.51	TRUE
BLA	Rai14	mRNA stability	Rai14	0.25	1	0.14	8.4e-08	-5.26	1.41e-07	0.29	FALSE
Brain	Rxfp3	gene expression	Rxfp3	0.05	1400	0.06	1.9e-06	-5.49	3.99e-08	0.44	FALSE
Brain	Tars1	gene expression	Tars1	0.3	1	0.25	2.4e-23	5.26	1.46e-07	0.27	FALSE
Brain	Ttc23l	gene expression	Ttc23l	0.08	73	0.1	2.7e-09	5.25	1.51e-07	0.54	FALSE
Brain	Rad1	mRNA stability	Rad1	0.12	45	0.15	1.4e-13	-5.24	1.59e-07	0.68	FALSE
Brain	Tars1	mRNA stability	Tars1	0.09	1	0.08	5.3e-08	5.21	1.93e-07	0.22	FALSE
Eye	Amacr	alternative TSS	XM_039101775.2	0.26	1450	0.12	8.0e-03	-5.46	4.80e-08	0.23	FALSE
Eye	Tars1	gene expression	Tars1	0.26	1427	0.03	1.0e-01	5.59	2.30e-08	0.2	FALSE
IC	Rad1	gene expression	Rad1	0.43	1	0.36	5.1e-16	-5.29	1.19e-07	0.62	FALSE
IC	Rxfp3	gene expression	Rxfp3	0.12	1	0.1	4.7e-05	-5.53	3.21e-08	0.14	FALSE
IC	Tars1	gene expression	Tars1	0.21	1	0.24	2.4e-10	5.3	1.17e-07	0.32	FALSE
IC	Ttc23l	gene expression	Ttc23l	0.09	1686	0.07	9.6e-04	5.35	8.98e-08	0.58	FALSE
IC	Rai14	mRNA stability	Rai14	0.21	1	0.2	5.9e-09	-5.53	3.21e-08	0.61	FALSE
IL	Rad1	mRNA stability	Rad1	0.19	1	0.14	3.6e-04	-5.29	1.24e-07	0.06	FALSE
IL	Rai14	mRNA stability	Rai14	0.3	25	0.33	1.2e-08	-5.34	9.44e-08	0.56	FALSE
LHb	LOC120100741	gene expression	LOC120100741	0.18	1383	0.04	4.0e-02	5.36	8.53e-08	0.26	FALSE
LHb	Tars1	gene expression	Tars1	0.16	1427	0.11	1.2e-03	5.37	7.74e-08	0.46	FALSE
Liver	Adamts12	gene expression	Adamts12	0.26	1383	0.26	7.9e-29	-5.48	4.23e-08	0.47	FALSE
Liver	Amacr	gene expression	Amacr	0.15	19	0.15	1.7e-16	-5.3	1.19e-07	0.44	FALSE
Liver	C1qtnf3	gene expression	C1qtnf3	0.1	1	0.1	2.8e-11	-5.35	8.81e-08	0.33	FALSE
Liver	Tars1	mRNA stability	Tars1	0.29	1427	0.23	3.2e-25	5.42	6.02e-08	0.55	FALSE
NAcc	Adamts12	gene expression	Adamts12	0.04	1383	0.06	1.5e-09	5.47	4.47e-08	0.43	FALSE
NAcc	Rad1	gene expression	Rad1	0.3	15	0.43	1.6e-72	-5.24	1.64e-07	0.64	FALSE
NAcc	Rai14	gene expression	Rai14	0.08	1	0.13	9.0e-20	-5.26	1.42e-07	0.3	FALSE
NAcc	Ttc23l	gene expression	Ttc23l	0.06	1	0.07	1.6e-11	5.32	1.02e-07	0.59	FALSE
NAcc	Rai14	isoform ratio	NM_001399209.1	0.03	1	0.04	9.5e-07	-5.28	1.30e-07	0.28	FALSE
NAcc	Rai14	intron excision ratio	chr2_61288750_61289772	0.02	1	0.02	2.4e-04	-5.52	3.30e-08	0.09	FALSE
NAcc	Rai14	intron excision ratio	chr2_61289858_61290910	0.02	23	0.02	8.8e-04	-5.38	7.44e-08	0.47	FALSE
NAcc	Rad1	mRNA stability	Rad1	0.08	1924	0.08	4.0e-12	-5.36	8.15e-08	0.71	FALSE
NAcc	Rai14	mRNA stability	Rai14	0.19	25	0.33	5.4e-51	-5.36	8.38e-08	0.44	FALSE
OFC	Rad1	gene expression	Rad1	0.33	1	0.16	1.2e-04	-5.29	1.24e-07	0.07	FALSE
OFC	Tars1	mRNA stability	Tars1	0.14	1	0.08	6.6e-03	5.39	6.88e-08	0.05	FALSE
PL	Npr3	gene expression	Npr3	0.09	38	0.02	2.8e-03	5.32	1.01e-07	0.54	FALSE
PL	Rxfp3	gene expression	Rxfp3	0.02	1	0.02	2.1e-03	-5.32	1.03e-07	0.03	FALSE
PL	Tars1	gene expression	Tars1	0.13	1427	0.24	1.5e-25	5.51	3.57e-08	0.55	FALSE
PL	Ttc23l	gene expression	Ttc23l	0.11	1	0.14	1.0e-14	5.37	7.67e-08	0.66	FALSE
PL	Rad1	mRNA stability	Rad1	0.07	1	0.08	9.0e-09	-5.51	3.62e-08	0.84	FALSE
PL	Rai14	mRNA stability	Rai14	0.22	288	0.31	8.2e-34	-5.45	5.12e-08	0.59	FALSE
pVTA	Rxfp3	gene expression	Rxfp3	0.09	1	0.15	2.1e-12	-5.59	2.28e-08	0.64	FALSE
pVTA	Tars1	gene expression	Tars1	0.15	5	0.22	2.1e-17	5.3	1.15e-07	0.54	FALSE