Hub : Genes

Cpxm1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000021220	0.05	0.04	7.7e-07	0.04	0.04	0.03	0.04	2.6e-05	4.7e-05	9.2e-05	1.8e-05
2	PL	gene expression	ENSRNOG00000021220	0.04	0.03	1.8e-03	0.04	0.03	0.03	0.03	2.7e-04	3.0e-03	2.5e-03	1.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	1.3	4.4	5.1	-1.9	2.3
BMI without tail	4.2	8.8	9.6	-2.8	3.1
Body weight	6.3	26.8	27.0	-5.2	5.2
Epididymis fat weight	1.5	3.5	3.7	-1.8	1.9
Glucose	0.2	0.3	0.4	-0.5	0.6
Heart weight	3.3	4.7	5.0	-2.1	2.2
Left kidney weight	1.1	3.0	3.3	-1.7	1.8
Right kidney weight	0.8	2.3	2.4	-1.5	1.5
Tail length	5.3	16.0	16.2	-4.0	4.0
Length with tail	4.9	17.9	18.8	-4.3	4.1
Length without tail	1.3	2.9	3.2	-1.8	1.6
Liver weight, left	0.1	0.2	0.2	0.5	-0.3
Liver weight, right	0.1	0.1	0.2	-0.1	0.4
Parametrial fat weight	0.1	0.1	0.3	0.5	0.1
Retroperitoneal fat weight	0.0	0.1	0.2	0.3	0.4
Intraocular pressure	0.0	0.0	0.0	-0.1	-0.1
Extensor digitorum longus weight	0.1	0.3	0.3	-0.6	0.4
Soleus weight	0.0	0.0	0.0	-0.2	-0.0
Tibialis anterior weight	0.8	2.8	3.1	-1.8	1.6
Tibia length	4.6	13.0	13.4	-3.7	3.5
Number of licking bursts	0.3	0.4	0.5	0.5	-0.7
Food consumed during 24 hour testing period	1.1	1.4	1.4	1.2	-1.2
Times rat made contact with spout	0.1	0.1	0.1	0.2	-0.4
Mean time between licks in bursts	0.0	0.1	0.1	0.0	0.3
Mean num. licks in bursts	0.1	0.2	0.2	-0.4	0.4
Std. dev. time between licks in bursts	0.7	0.8	1.2	-0.7	1.1
Water consumed over 24 hours	0.2	0.3	0.5	0.3	-0.7
Indifference point 0 sec	0.0	0.1	0.1	-0.4	-0.0
Indifference point AUC	0.6	0.7	0.8	-0.8	0.9
Indifference point function ln k	0.1	0.1	0.1	-0.3	0.4
Indifference point function log k	0.1	0.1	0.1	-0.3	0.4
Delay discounting total patch changes 0 sec	0.0	0.1	0.2	-0.4	0.0
Delay discounting total patch changes 12 sec	0.3	0.5	0.6	-0.6	0.8
Delay discounting total patch changes 18 sec	0.7	1.0	1.1	0.9	-1.0
Delay discounting total patch changes 24 sec	1.7	2.2	2.2	1.5	-1.5
Delay discounting total patch changes 6 sec	0.3	0.5	0.7	-0.8	0.6
Delay discounting time to switch 0 sec	1.8	2.8	3.0	1.7	-1.6
Delay discounting water rate 0 sec	3.5	5.5	6.0	-2.5	2.2
Delay discounting water rate 12 sec	0.0	0.0	0.1	-0.3	-0.1
Delay discounting water rate 18 sec	0.3	0.4	0.4	-0.6	0.6
Delay discounting water rate 24 sec	0.4	0.6	0.8	-0.9	0.7
Delay discounting water rate 6 sec	1.7	2.5	3.0	-1.7	1.4
Locomotor activity	0.2	0.3	0.3	-0.5	0.5
Locomotor testing distance	0.1	0.2	0.3	0.4	-0.6
Locomotor testing rearing	0.1	0.2	0.3	-0.6	0.3
Light reinforcement 1	1.0	1.9	2.5	-1.6	1.1
Light reinforcement 2	0.8	1.1	1.5	-1.2	0.8
Reaction time number correct	0.1	0.2	0.3	-0.6	0.3
Reaction time mean minus median	0.9	1.2	1.4	1.0	-1.2
Reaction time mean minus median AUC	0.6	0.8	1.0	0.7	-1.0
Reaction time num false alarms	2.2	3.0	3.3	-1.6	1.8
Reaction time num false alarms AUC	2.4	3.4	3.7	-1.7	1.9
Reaction time trials correct on left	0.1	0.2	0.3	-0.6	0.3
Reaction time trials on left	0.2	0.3	0.4	-0.7	0.3
Reaction time mean	0.0	0.0	0.0	0.1	-0.2
Reaction time mean AUC	0.0	0.0	0.1	0.2	-0.3
Median of all reaction times	0.0	0.0	0.0	-0.2	0.1
Reaction time omissions	0.4	0.5	0.7	-0.9	0.6
Reaction time false alarm rate	1.3	1.9	2.3	-1.2	1.5
Reaction time premature initiation rate	0.2	0.2	0.3	0.4	-0.6
Reaction time premature initiations	0.1	0.1	0.2	0.2	-0.5
Std. dev. reaction times	0.1	0.1	0.2	-0.4	0.2
Reaction time trials completed	0.2	0.3	0.4	-0.7	0.3
Reaction time trials AUC	0.2	0.3	0.5	-0.7	0.4
Social response proportion	1.4	1.5	2.0	-1.4	1.1
Social responses	5.1	6.6	7.3	-2.7	2.4
Social time	0.5	0.6	0.7	-0.9	0.7
Conditioned locomotion	4.2	5.0	5.2	-2.3	2.2
Cocaine response after cond. corrected	0.1	0.1	0.1	0.3	-0.2
Cocaine response after cond. not corrected	0.1	0.2	0.2	0.4	-0.4
Cocaine response before conditioning	0.2	0.3	0.5	0.3	-0.7
Saline control response	7.3	9.8	10.0	-3.1	3.2
Condit. Reinf. active minus inactive responses	2.0	2.5	3.1	-1.8	1.3
Condit. Reinf. active-inactive response ratio	1.9	2.0	2.6	-1.6	1.2
Condit. Reinf. active responses	3.3	4.6	5.8	-2.4	1.8
Condit. Reinf. inactive responses	0.6	0.8	1.0	-1.0	0.7
Condit. Reinf. lever presses	1.3	1.8	2.2	-1.5	1.2
Condit. Reinf. lever reinforcers received	2.5	3.5	4.4	-2.1	1.6
Pavlov. Cond. lever latency	4.2	5.8	6.0	2.4	-2.4
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.2	0.3
Pavlov. Cond. change in total contacts	4.1	5.8	6.1	-2.5	2.3
Pavlov. Cond. index score	3.6	4.7	4.9	-2.1	2.2
Pavlov. Cond. latency score	2.7	3.5	3.6	-1.8	1.9
Pavlov. Cond. lever contacts	4.0	5.5	5.8	-2.4	2.3
Pavlov. Cond. magazine entry number	0.6	0.7	0.8	0.9	-0.8
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.4	1.2	-0.9
Pavlov. Cond. lever-magazine prob. diff.	3.2	4.2	4.4	-2.0	2.1
Pavlov. Cond. response bias	4.2	5.8	6.2	-2.5	2.3
Conditioned reinforcement - actives	0.0	0.0	0.0	-0.0	-0.1
Conditioned reinforcement - inactives	0.2	0.2	0.3	-0.6	0.3
Conditioned locomotion	0.1	0.1	0.2	0.4	-0.3
Intermittent access intake day 1-15 change	0.3	0.3	0.4	-0.5	0.7
Intermittent access intake escalation	0.0	0.0	0.0	-0.2	0.2
Intermittent access intake escalation 2	0.3	0.2	0.3	0.6	-0.4
Intermitt. access day 1 inactive lever presses	0.3	0.4	0.6	0.4	-0.8
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.1	0.2	-0.2
Intermitt. access escalation Index	0.0	0.0	0.0	0.1	0.2
Intermittent access day 1 total infusions	0.1	0.1	0.2	0.4	-0.0
Intermittent access day 15 total infusions	0.0	0.0	0.0	0.1	0.1
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.0	0.1	0.1
Intermittent access total infusions	0.0	0.0	0.1	0.3	0.0
Intermittent access day 1 locomotion	0.2	0.2	0.2	0.4	-0.5
Intermittent access day 15 total locomotion	0.1	0.1	0.1	0.3	-0.3
Intermittent access total locomotion	0.1	0.1	0.2	0.4	-0.3
Intermittent access standard deviation	0.0	0.0	0.0	-0.2	0.1
Cocaine induced anxiety	6.2	7.1	7.4	2.6	-2.7
Post-drug Anxiety	2.1	2.3	2.7	1.4	-1.6
Baseline Anxiety	0.7	0.8	0.9	-0.9	0.8
Lifetime Intake	0.1	0.1	0.3	-0.1	0.5
Incentive Sensitization - Responses	0.3	0.3	0.5	-0.2	0.7
Incentive Sensitization - Breakpoint	0.1	0.1	0.3	0.0	0.5
Progressive ratio test 1 active lever presses	2.9	3.0	3.7	-1.5	1.9
Progressive ratio test 1 breakpoint	3.8	3.9	4.7	-1.8	2.2
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.2	-0.5	0.4
Progressive ratio test 2 active lever presses	0.2	0.2	0.4	-0.2	0.7
Progressive ratio test 2 breakpoint	0.2	0.2	0.4	-0.2	0.7
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.1	-0.3	0.2
Total sessions with >9 infusions	0.5	0.6	0.8	-0.6	0.9
Short access day 1 total inactive lever presses	0.6	0.7	0.8	0.8	-0.9
Short access day 10 total inactive lever presses	4.4	4.9	5.0	2.2	-2.2
Short access day 1 total infusions	0.0	0.0	0.1	0.0	0.3
Short access day 10 total infusions	0.0	0.0	0.1	0.1	0.3
Short access total infusions	0.3	0.4	0.6	-0.4	0.8
Short access day 1 locomotion	1.0	1.1	1.2	1.1	-0.9
Short access day 10 total locomotion	0.0	0.0	0.0	-0.1	-0.1
Short access total locomotion	0.0	0.0	0.0	0.0	-0.1
Compulsive drug intake	4.3	4.3	4.8	2.0	-2.2
One hour access (0.3 mA shock)	0.1	0.1	0.1	0.3	-0.3
One hour access (shock baseline)	0.2	0.3	0.4	-0.4	0.6
Number of responses in last shaping day	0.2	0.2	0.3	0.2	-0.5
Context. condit. distance diff. score	0.0	0.1	0.1	-0.2	0.3
Locomotion velocity, session 1	0.4	0.4	0.5	-0.7	0.6
Locomotion distance, session 1	0.3	0.4	0.4	-0.6	0.6
Locomotion velocity, session 2	0.0	0.0	0.0	0.2	-0.1
Locomotion distance, session 2	1.3	1.9	1.9	-1.4	1.4
Locomotion velocity, session 3	1.7	2.0	2.2	-1.3	1.5
Locomotion distance, session 3	7.9	8.6	9.4	-2.8	3.1
Stereotopy head waving bouts, day 3	1.4	1.7	2.2	1.1	-1.5
Stereotopy head waving duration, day 3	1.0	1.2	1.6	0.9	-1.3
Locomotion velocity, session 7	1.0	1.1	1.2	-1.1	1.0
Locomotion distance, session 7	0.9	1.2	1.3	-1.0	1.2
Stereotopy head waving bouts, day 7	0.4	0.4	0.6	-0.8	0.5
Stereotopy head waving duration, day 7	0.1	0.1	0.1	-0.4	0.1
Locomotion velocity, session 8	0.4	0.5	0.6	-0.6	0.8
Locomotion distance, session 8	2.3	3.4	3.8	-1.7	2.0
Degree of sensitization distance	2.2	2.2	2.4	1.4	-1.5
Degree of sensitization stereotypy	2.3	2.5	2.7	-1.6	1.5
Condit. Reinf. active minus inactive responses	1.0	1.1	1.1	-1.1	1.1
Condit. Reinf. active-inactive response ratio	0.8	0.8	0.8	-0.9	0.9
Condit. Reinf. active responses	0.8	0.9	1.0	-1.0	1.0
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.1	0.0
Incentive salience index mean	0.7	0.9	1.1	-0.8	1.1
Condit. Reinf. lever presses	0.2	0.3	0.5	-0.4	0.7
Time in familiar zone, hab. session 1	1.3	1.2	1.3	1.2	-1.0
Time in novel zone, hab. session 1	0.5	0.5	0.5	-0.7	0.7
Total zone transitions, hab. session 1	0.3	0.4	0.5	-0.5	0.7
Total locomotion distance, hab. session 1	0.1	0.1	0.1	-0.3	0.2
Locomotion velocity, hab. session 1	0.1	0.2	0.2	-0.4	0.4
Time in familiar zone, hab. session 2	1.9	1.9	2.1	1.5	-1.3
Time in novel zone, hab. session 2	1.8	1.8	2.1	-1.5	1.2
Total zone transitions, hab. session 2	3.1	4.0	4.5	-1.8	2.1
Total locomotion distance, hab. session 2	0.8	1.0	1.0	-1.0	1.0
Locomotion velocity, hab. session 2	0.3	0.4	0.4	-0.7	0.7
Novel to familiar place preference ratio	0.3	0.3	0.4	0.6	-0.4
Novelty place preference	0.5	0.5	0.7	0.8	-0.6
Time in novel zone, NPP test	0.3	0.3	0.4	0.6	-0.4
Total zone transitions, NPP test	0.3	0.4	0.5	-0.6	0.7
Total locomotion distance, NPP test	0.2	0.3	0.4	-0.6	0.5
Locomotion velocity, NPP test	0.0	0.0	0.1	-0.3	0.1
Pavlov. Cond. lever latency	0.2	0.2	0.5	-0.7	-0.0
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.3	0.3
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.1	0.4
Pavlov. Cond. index score	0.0	0.0	0.1	0.1	0.3
Pavlov. Cond. latency score	0.1	0.1	0.1	0.4	0.1
Pavlov. Cond. lever contacts	0.2	0.2	0.4	-0.1	0.6
Pavlov. Cond. magazine entry number	0.6	0.8	0.8	0.9	-0.9
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	-0.3	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	0.1	0.2
Pavlov. Cond. response bias	0.5	0.6	0.8	-0.7	0.9
Bone: apparent density	0.4	0.7	0.7	-0.8	0.8
Bone surface	0.7	1.2	1.3	-1.1	1.2
Bone volume	0.7	1.1	1.2	-1.0	1.1
Bone: connectivity density	0.1	0.2	0.2	-0.4	0.4
Bone: cortical apparent density	0.8	1.0	1.2	-1.1	0.9
Bone: cortical area	3.9	5.8	6.9	-2.2	2.6
Bone: cortical porosity	0.2	0.3	0.4	-0.3	0.7
Bone: cortical porosity	0.7	0.8	1.1	-0.7	1.1
Bone: cortical thickness	1.9	3.1	3.8	-1.5	2.0
Bone: cortical thickness	0.3	0.3	0.4	-0.5	0.6
Bone: cortical tissue density	0.6	0.8	0.9	-1.0	0.8
Bone: elastic displacement	0.0	0.0	0.0	-0.1	-0.1
Bone: elastic work	0.0	0.0	0.0	-0.2	0.2
Bone: endosteal estimation	0.5	1.1	1.4	-0.9	1.2
Bone: endosteal perimeter	2.2	4.6	5.0	-2.0	2.2
Bone: final force	4.0	6.6	7.4	-2.4	2.7
Bone: final moment	3.1	5.2	6.1	-2.1	2.5
Bone: marrow area	0.5	1.0	1.3	-0.9	1.1
Bone: maximum diameter	4.5	8.2	9.0	-2.7	3.0
Bone: maximum force	0.7	1.3	1.7	-0.9	1.3
Bone: maximum moment	0.3	0.6	0.9	-0.5	0.9
Bone: minimum diameter	1.9	3.5	4.5	-1.6	2.1
Bone: periosteal estimation	2.6	5.3	6.2	-2.1	2.5
Bone: periosteal perimeter	3.5	5.8	6.8	-2.2	2.6
Bone: post-yield work	0.8	1.1	1.3	1.1	-1.0
Bone: stiffness	2.1	3.4	4.1	-1.6	2.0
Bone: tissue strength	0.2	0.2	0.2	-0.4	0.5
Bone: trabecular number	0.6	1.0	1.2	-1.1	0.9
Bone: trabecular spacing	0.1	0.1	0.2	0.4	-0.3
Bone: trabecular thickness	0.4	0.5	0.7	-0.6	0.8
Bone: trabecular tissue density	1.6	2.3	2.7	-1.4	1.6
Breakpoint value in progressive ratio session	3.5	3.9	4.0	-2.0	2.0
Distance traveled before self-admin	4.4	4.7	5.6	-1.9	2.4
Distance traveled after self-admin	2.8	3.1	3.3	-1.8	1.7
Delta time in closed arm before/after self-admin	0.2	0.2	0.2	0.4	-0.4
Delta time in open arm before/after self-admin	0.5	0.4	0.4	-0.6	0.7
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.1	0.0
Extinction: sum of active levers before priming	0.6	0.6	0.7	-0.8	0.7
Active lever presses in extinction session 6	0.1	0.1	0.2	0.4	-0.3
Delta distance traveled before/after self-admin	0.3	0.3	0.5	-0.7	0.4
Delta ambulatory time before/after self-admin	0.3	0.3	0.5	0.4	-0.7
Time in closed arm before self-admin	0.1	0.2	0.2	0.5	-0.3
Time in closed arm after self-admin	0.3	0.4	0.5	0.7	-0.5
Time in open arm before self-admin	0.2	0.2	0.3	0.5	-0.4
Time in open arm after self-admin	0.0	0.0	0.0	-0.0	-0.0
Sum of active levers in priming session hrs 5-6	1.0	1.0	1.2	-1.1	0.9
Time to tail flick, vehicle, before self-admin	1.8	1.8	2.4	1.1	-1.6
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	0.1	0.1
Time to tail flick, test, before self-admin	1.2	1.2	1.4	-1.2	1.0
Time to tail flick, test, after self-admin	2.6	2.7	2.8	1.7	-1.6
Delta time to tail flick, vehicle, before/after SA	3.6	3.5	4.1	-1.7	2.0
Delta time to tail flick, test, before/after SA	3.8	3.4	3.7	1.7	-1.9
Ambulatory time before self-admin	4.3	4.5	4.6	-2.1	2.2
Ambulatory time after self-admin	3.8	4.2	4.3	-2.1	2.0
Total heroin consumption	3.7	4.5	5.1	-2.3	2.0
Area under the delay curve	0.1	0.1	0.2	0.4	-0.4
Delay disc. indifference point, 0s delay	2.7	3.0	3.4	1.8	-1.6
Delay disc. indifference point, 16s delay	0.5	0.5	0.5	0.7	-0.6
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	0.2	-0.0
Delay disc. indifference point, 24s delay	2.2	2.1	2.2	1.5	-1.4
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	-0.3	0.3
Delay disc. indifference point, 8s delay	0.2	0.2	0.2	0.4	-0.4
Delay discount exponential model param	0.1	0.1	0.1	-0.4	0.3
Delay discount hyperbolic model param	0.1	0.1	0.1	-0.4	0.2
Fecal boli incidents, locomotor time 1	0.1	0.1	0.1	-0.3	0.3
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	0.2	-0.3
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	-0.2	0.2
Bouts of movement, locomotor time 1	2.1	2.4	2.8	1.7	-1.4
Total resting periods, locomotor time 1	1.6	1.8	2.0	1.4	-1.3
Rest time, locomotor task time 1	0.2	0.2	0.2	0.5	-0.5
Distance moved, locomotor task time 1	0.0	0.0	0.0	-0.2	0.1
Vertical activity count, locomotor time 1	0.2	0.2	0.3	-0.4	0.5
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	0.1	0.1
Bouts of movement, locomotor time 2	0.7	0.7	1.0	1.0	-0.6
Total resting periods, locomotor time 2	0.6	0.7	0.9	0.9	-0.7
Rest time, locomotor task time 2	0.7	0.8	1.2	0.6	-1.1
Distance moved, locomotor task time 2	0.0	0.1	0.1	0.1	0.3
Vertical activity count, locomotor time 2	0.2	0.2	0.4	-0.2	0.6
Weight adjusted by age	3.8	4.2	5.0	-2.2	1.9
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.2	0.4	-0.5
Locomotion in novel chamber	0.1	0.1	0.2	0.3	-0.4
Locomotion in novel chamber post-restriction	1.1	1.2	1.6	-1.2	1.0
Progressive ratio	3.0	3.5	3.7	1.8	-1.9
Food seeking constrained by brief footshock	0.3	0.4	0.5	-0.5	0.7
Seeking ratio, punishment vs. effort	3.1	3.8	4.2	-1.9	2.1
Run reversals in cocaine runway, females	0.0	0.0	0.1	0.1	-0.2
Run reversals in cocaine runway, males	1.1	1.0	1.3	-1.1	0.9
Latency to leave start box in cocaine runway	0.4	0.5	0.8	0.9	-0.4
Latency to leave start box in cocaine runway, F	1.1	1.2	1.7	1.3	-0.9
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.2	0.4
Cd content in liver	0.0	0.0	0.1	0.2	-0.1
Co content in liver	0.8	0.9	1.1	-1.0	0.9
Cu content in liver	2.0	2.4	2.9	-1.7	1.4
Fe content in liver	0.0	0.0	0.0	0.1	0.1
K content in liver	0.4	0.4	0.6	-0.5	0.8
Mg content in liver	1.9	1.9	2.2	-1.3	1.5
Mn content in liver	2.2	2.6	2.6	-1.6	1.6
Na content in liver	0.1	0.1	0.1	0.4	0.1
Rb content in liver	3.5	4.3	4.9	-2.2	2.0
Se content in liver	0.8	0.9	1.0	-1.0	0.9
Sr content in liver	0.5	0.5	0.5	-0.7	0.7
Zn content in liver	0.3	0.3	0.4	-0.5	0.6