Hub : Genes

Xab2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000000988	0.14	0.07	2.2e-06	0.05	0.04	0.04	0.04	2.2e-06	8.0e-05	1.2e-05	1.5e-05
2	Brain	mRNA stability	ENSRNOG00000000988	0.05	0.03	4.1e-04	0.04	0.04	0.03	0.03	7.8e-05	2.7e-04	7.3e-04	3.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	0.5	1.5	2.3	-1.5	-0.8
BMI without tail	1.7	3.5	5.9	-2.4	-1.0
Body weight	6.2	26.3	52.6	-7.3	0.1
Epididymis fat weight	0.1	0.2	0.4	-0.1	-0.6
Glucose	0.7	1.0	1.1	1.1	-1.0
Heart weight	0.5	0.7	1.0	-1.0	-0.7
Left kidney weight	6.2	17.7	35.1	-5.9	0.6
Right kidney weight	4.7	13.4	26.3	-5.1	0.7
Tail length	4.5	13.7	26.7	-5.2	-0.8
Length with tail	8.7	31.8	63.7	-8.0	0.1
Length without tail	4.2	9.2	18.3	-4.3	0.3
Liver weight, left	2.3	3.7	5.2	-1.5	2.3
Liver weight, right	2.7	4.6	8.3	-2.9	0.9
Parametrial fat weight	0.2	0.4	0.8	-0.2	0.9
Retroperitoneal fat weight	1.4	4.6	6.3	2.5	-1.7
Intraocular pressure	1.3	1.8	3.4	-1.8	0.4
Extensor digitorum longus weight	2.9	11.8	23.5	-4.8	-0.3
Soleus weight	1.1	3.2	5.9	-2.4	0.7
Tibialis anterior weight	3.6	12.4	24.1	-4.9	-0.8
Tibia length	1.8	5.2	10.0	-3.2	0.7
Number of licking bursts	1.4	1.6	1.8	-1.3	1.2
Food consumed during 24 hour testing period	0.5	0.7	1.0	-0.6	1.0
Times rat made contact with spout	0.7	0.8	1.3	-1.2	-0.5
Mean time between licks in bursts	0.8	1.1	2.1	1.5	0.3
Mean num. licks in bursts	0.3	0.4	0.6	0.3	-0.8
Std. dev. time between licks in bursts	0.2	0.3	0.4	-0.7	-0.4
Water consumed over 24 hours	2.2	2.6	4.7	-2.2	0.8
Indifference point 0 sec	1.7	2.7	5.2	-0.5	2.3
Indifference point AUC	0.9	1.1	2.0	-1.4	0.4
Indifference point function ln k	0.1	0.1	0.2	-0.3	0.4
Indifference point function log k	0.1	0.1	0.2	-0.3	0.4
Delay discounting total patch changes 0 sec	2.0	3.3	6.4	-0.5	2.5
Delay discounting total patch changes 12 sec	1.0	1.3	2.2	-0.6	1.5
Delay discounting total patch changes 18 sec	2.3	3.1	5.5	-0.8	2.4
Delay discounting total patch changes 24 sec	1.1	1.4	2.1	-0.8	1.4
Delay discounting total patch changes 6 sec	1.6	2.5	4.1	-0.9	2.0
Delay discounting time to switch 0 sec	2.7	4.1	7.0	2.6	-1.0
Delay discounting water rate 0 sec	4.2	6.6	9.1	-3.0	2.0
Delay discounting water rate 12 sec	0.5	0.7	1.3	-1.1	0.4
Delay discounting water rate 18 sec	0.4	0.6	1.0	-0.3	-1.0
Delay discounting water rate 24 sec	1.7	2.4	4.5	-2.1	0.5
Delay discounting water rate 6 sec	0.6	0.8	1.4	-1.2	0.5
Locomotor activity	2.2	3.4	5.8	-2.4	-1.0
Locomotor testing distance	1.0	1.7	2.8	-1.7	0.8
Locomotor testing rearing	0.5	0.8	1.6	-0.1	1.3
Light reinforcement 1	1.4	2.6	3.6	1.3	-1.9
Light reinforcement 2	0.1	0.2	0.2	0.4	0.4
Reaction time number correct	1.1	1.5	1.6	-1.3	1.2
Reaction time mean minus median	3.8	5.0	10.0	-0.0	-3.2
Reaction time mean minus median AUC	1.7	2.2	4.2	0.5	-2.0
Reaction time num false alarms	1.2	1.7	3.3	0.2	-1.8
Reaction time num false alarms AUC	0.8	1.1	2.1	-0.0	-1.5
Reaction time trials correct on left	1.1	1.5	1.6	-1.3	1.2
Reaction time trials on left	1.0	1.4	1.6	-1.2	1.1
Reaction time mean	4.2	5.7	5.8	2.4	-2.4
Reaction time mean AUC	4.1	5.5	5.6	2.4	-2.3
Median of all reaction times	4.5	6.1	8.7	3.0	-1.9
Reaction time omissions	1.7	2.3	3.2	1.2	-1.8
Reaction time false alarm rate	1.4	2.0	3.9	0.5	-2.0
Reaction time premature initiation rate	0.6	0.8	1.5	0.0	-1.2
Reaction time premature initiations	0.2	0.3	0.4	-0.4	-0.6
Std. dev. reaction times	3.0	4.1	7.1	1.0	-2.7
Reaction time trials completed	1.0	1.4	1.6	-1.2	1.1
Reaction time trials AUC	0.8	1.2	1.2	-1.1	1.1
Social response proportion	3.8	4.1	4.8	-2.2	-1.8
Social responses	1.6	2.1	3.8	-1.9	-0.7
Social time	1.9	2.5	3.1	1.8	-1.4
Conditioned locomotion	0.4	0.5	0.9	-0.0	0.9
Cocaine response after cond. corrected	0.3	0.4	0.5	0.7	0.5
Cocaine response after cond. not corrected	0.2	0.2	0.4	0.7	-0.2
Cocaine response before conditioning	0.8	1.0	1.9	-0.4	-1.4
Saline control response	2.6	3.5	6.5	-2.5	0.7
Condit. Reinf. active minus inactive responses	2.0	2.4	3.3	-1.2	-1.8
Condit. Reinf. active-inactive response ratio	1.9	2.0	3.5	-0.6	-1.9
Condit. Reinf. active responses	2.0	2.8	3.8	-1.3	-1.9
Condit. Reinf. inactive responses	0.3	0.3	0.6	-0.8	-0.2
Condit. Reinf. lever presses	0.3	0.4	0.7	-0.4	-0.8
Condit. Reinf. lever reinforcers received	1.9	2.7	4.2	-1.1	-2.1
Pavlov. Cond. lever latency	1.5	2.1	4.1	-0.2	2.0
Pavlov. Cond. magazine entry latency	3.2	3.7	4.9	1.6	-2.2
Pavlov. Cond. change in total contacts	0.8	1.1	2.2	0.2	-1.5
Pavlov. Cond. index score	2.0	2.6	4.5	0.9	-2.1
Pavlov. Cond. latency score	2.0	2.6	4.2	1.0	-2.0
Pavlov. Cond. lever contacts	1.3	1.8	3.4	0.4	-1.8
Pavlov. Cond. magazine entry number	2.4	3.0	3.9	-1.4	2.0
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.5	-1.2	0.4
Pavlov. Cond. lever-magazine prob. diff.	2.2	2.8	4.8	0.9	-2.2
Pavlov. Cond. response bias	2.2	3.0	5.3	0.8	-2.3
Conditioned reinforcement - actives	3.6	3.6	7.1	-2.7	-0.2
Conditioned reinforcement - inactives	0.8	0.9	1.0	-1.0	1.0
Conditioned locomotion	2.2	2.6	5.2	-2.3	-0.2
Intermittent access intake day 1-15 change	2.1	2.1	2.3	-1.5	1.3
Intermittent access intake escalation	1.7	1.7	2.5	-1.6	0.9
Intermittent access intake escalation 2	0.4	0.4	0.6	-0.6	0.7
Intermitt. access day 1 inactive lever presses	1.2	1.3	1.8	-0.9	1.3
Intermitt. access day 15 inactive lever presses	1.0	1.1	1.7	0.7	1.3
Intermitt. access escalation Index	0.1	0.1	0.2	0.1	-0.4
Intermittent access day 1 total infusions	1.0	1.1	1.6	0.9	-1.2
Intermittent access day 15 total infusions	0.1	0.1	0.2	-0.5	0.0
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	0.3	-0.0
Intermittent access total infusions	0.6	0.6	0.8	0.7	-0.9
Intermittent access day 1 locomotion	2.1	2.1	2.1	1.4	-1.5
Intermittent access day 15 total locomotion	0.6	0.6	1.0	-0.5	-1.0
Intermittent access total locomotion	1.4	1.6	2.6	0.8	-1.6
Intermittent access standard deviation	1.6	1.7	3.2	-0.4	1.8
Cocaine induced anxiety	0.5	0.6	0.7	0.7	-0.8
Post-drug Anxiety	4.4	4.8	6.2	2.5	-1.9
Baseline Anxiety	3.6	3.8	6.5	2.5	-1.1
Lifetime Intake	0.6	0.7	0.9	1.0	-0.7
Incentive Sensitization - Responses	0.2	0.2	0.3	-0.2	-0.6
Incentive Sensitization - Breakpoint	0.2	0.2	0.3	-0.3	-0.6
Progressive ratio test 1 active lever presses	0.3	0.3	0.5	-0.7	-0.1
Progressive ratio test 1 breakpoint	0.3	0.3	0.5	-0.7	-0.2
Progressive ratio test 1 inactive lever presses	1.1	1.2	2.2	-1.5	0.5
Progressive ratio test 2 active lever presses	1.1	1.2	2.0	-1.4	-0.7
Progressive ratio test 2 breakpoint	0.9	1.0	1.1	-1.0	-0.9
Progressive ratio test 2 inactive lever presses	3.2	3.7	6.1	-2.5	1.2
Total sessions with >9 infusions	0.1	0.1	0.3	0.1	-0.5
Short access day 1 total inactive lever presses	0.2	0.2	0.4	-0.2	0.7
Short access day 10 total inactive lever presses	2.8	3.0	3.4	-1.6	1.8
Short access day 1 total infusions	1.6	1.7	2.8	1.7	0.8
Short access day 10 total infusions	0.6	0.7	1.3	1.2	-0.2
Short access total infusions	0.9	1.0	1.9	1.4	-0.2
Short access day 1 locomotion	2.0	2.2	2.7	1.3	-1.7
Short access day 10 total locomotion	0.3	0.4	0.6	0.8	0.4
Short access total locomotion	1.4	1.4	2.1	1.5	-0.9
Compulsive drug intake	1.6	1.6	3.1	1.8	0.2
One hour access (0.3 mA shock)	0.4	0.5	0.8	-0.9	0.4
One hour access (shock baseline)	1.4	1.6	3.0	-1.7	-0.5
Number of responses in last shaping day	0.1	0.1	0.1	-0.2	0.3
Context. condit. distance diff. score	2.3	2.8	4.6	-2.1	-1.0
Locomotion velocity, session 1	0.7	0.7	0.9	0.8	-1.0
Locomotion distance, session 1	0.7	0.9	1.4	1.2	-0.5
Locomotion velocity, session 2	0.3	0.4	0.6	0.4	-0.8
Locomotion distance, session 2	0.3	0.4	0.7	0.8	-0.4
Locomotion velocity, session 3	0.2	0.2	0.3	-0.4	-0.5
Locomotion distance, session 3	0.2	0.2	0.4	-0.1	0.7
Stereotopy head waving bouts, day 3	1.9	2.3	3.8	-1.9	0.9
Stereotopy head waving duration, day 3	0.1	0.1	0.2	-0.1	0.4
Locomotion velocity, session 7	2.1	2.3	3.7	0.9	-1.9
Locomotion distance, session 7	0.9	1.2	2.3	0.2	-1.5
Stereotopy head waving bouts, day 7	0.3	0.3	0.5	0.7	-0.3
Stereotopy head waving duration, day 7	0.4	0.4	0.8	0.9	-0.3
Locomotion velocity, session 8	0.4	0.5	0.9	-0.2	-0.9
Locomotion distance, session 8	0.8	1.1	1.5	-1.2	-0.9
Degree of sensitization distance	1.4	1.4	2.0	0.9	-1.4
Degree of sensitization stereotypy	0.4	0.4	0.6	0.8	-0.6
Condit. Reinf. active minus inactive responses	0.9	1.0	1.4	1.2	-0.8
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.0	0.8	-1.0
Condit. Reinf. active responses	0.5	0.6	0.6	0.8	-0.8
Condit. Reinf. inactive responses	0.3	0.3	0.4	0.5	-0.6
Incentive salience index mean	0.6	0.7	0.9	0.9	-0.7
Condit. Reinf. lever presses	0.2	0.2	0.3	0.5	-0.5
Time in familiar zone, hab. session 1	1.2	1.1	1.9	0.6	1.4
Time in novel zone, hab. session 1	0.6	0.6	0.8	-0.6	-0.9
Total zone transitions, hab. session 1	1.1	1.6	1.6	1.2	-1.3
Total locomotion distance, hab. session 1	0.8	1.1	1.2	1.0	-1.1
Locomotion velocity, hab. session 1	1.4	2.0	2.1	1.4	-1.4
Time in familiar zone, hab. session 2	0.1	0.1	0.2	0.5	0.2
Time in novel zone, hab. session 2	0.2	0.2	0.3	0.2	-0.6
Total zone transitions, hab. session 2	0.1	0.2	0.2	-0.4	-0.4
Total locomotion distance, hab. session 2	0.1	0.2	0.2	0.3	-0.5
Locomotion velocity, hab. session 2	0.1	0.1	0.2	0.2	-0.5
Novel to familiar place preference ratio	0.1	0.1	0.2	-0.0	-0.4
Novelty place preference	0.1	0.1	0.2	0.3	-0.4
Time in novel zone, NPP test	0.1	0.1	0.2	0.1	-0.4
Total zone transitions, NPP test	0.2	0.3	0.5	-0.2	-0.7
Total locomotion distance, NPP test	0.9	1.2	2.3	0.3	-1.5
Locomotion velocity, NPP test	0.8	1.1	2.2	-0.0	-1.5
Pavlov. Cond. lever latency	2.0	2.5	4.1	-2.0	1.0
Pavlov. Cond. magazine entry latency	0.3	0.3	0.4	-0.5	-0.7
Pavlov. Cond. change in total contacts	1.6	1.7	2.3	1.0	-1.5
Pavlov. Cond. index score	0.4	0.5	0.9	0.5	-0.9
Pavlov. Cond. latency score	0.8	1.0	1.3	0.8	-1.2
Pavlov. Cond. lever contacts	1.6	1.8	2.9	1.7	-0.9
Pavlov. Cond. magazine entry number	0.5	0.7	0.7	0.8	0.9
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.9	1.0	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.5	0.4	-0.7
Pavlov. Cond. response bias	0.3	0.3	0.6	-0.1	-0.8
Bone: apparent density	3.7	6.2	8.0	-2.8	2.1
Bone surface	2.8	4.9	8.3	-2.9	1.2
Bone volume	2.1	3.5	4.3	-2.1	1.6
Bone: connectivity density	4.6	7.3	12.5	-3.5	1.4
Bone: cortical apparent density	0.9	1.1	1.3	1.0	-1.2
Bone: cortical area	1.1	1.7	2.3	-1.5	-1.1
Bone: cortical porosity	0.1	0.1	0.1	-0.3	0.4
Bone: cortical porosity	0.0	0.0	0.0	0.1	-0.2
Bone: cortical thickness	0.9	1.5	2.3	-1.5	-0.8
Bone: cortical thickness	1.0	1.2	2.2	-1.5	-0.5
Bone: cortical tissue density	0.8	1.0	1.0	1.0	-1.0
Bone: elastic displacement	0.5	0.6	0.9	-0.9	0.5
Bone: elastic work	2.8	3.6	6.7	-2.6	0.8
Bone: endosteal estimation	1.1	2.4	3.0	-1.7	1.4
Bone: endosteal perimeter	0.6	1.3	2.6	-1.6	0.2
Bone: final force	1.5	2.4	4.7	-2.2	-0.3
Bone: final moment	1.2	2.0	3.9	-2.0	-0.2
Bone: marrow area	1.2	2.6	3.0	-1.7	1.4
Bone: maximum diameter	0.8	1.5	2.9	-1.7	0.3
Bone: maximum force	1.5	2.5	5.0	-2.2	0.1
Bone: maximum moment	1.3	2.2	4.2	-2.1	0.3
Bone: minimum diameter	0.0	0.0	0.0	-0.1	0.2
Bone: periosteal estimation	1.1	2.3	4.5	-2.1	0.2
Bone: periosteal perimeter	0.7	1.2	1.6	-1.3	-0.9
Bone: post-yield work	0.2	0.3	0.4	-0.6	0.4
Bone: stiffness	0.7	1.2	1.5	-1.2	-0.9
Bone: tissue strength	1.6	1.5	3.1	-0.0	1.8
Bone: trabecular number	2.8	4.4	7.2	-2.7	1.2
Bone: trabecular spacing	2.0	2.5	5.0	2.2	-0.2
Bone: trabecular thickness	2.8	3.4	6.3	-2.5	0.7
Bone: trabecular tissue density	4.1	5.8	11.5	0.3	-3.4
Breakpoint value in progressive ratio session	1.3	1.5	2.8	-0.4	-1.7
Distance traveled before self-admin	1.3	1.3	2.0	0.8	-1.4
Distance traveled after self-admin	0.2	0.2	0.4	-0.2	-0.6
Delta time in closed arm before/after self-admin	0.4	0.4	0.7	-0.4	-0.8
Delta time in open arm before/after self-admin	1.8	1.7	3.5	1.9	0.0
Diff in mean of infusions in LGA sessions	0.1	0.1	0.1	-0.2	-0.3
Extinction: sum of active levers before priming	1.0	1.0	1.1	1.1	-0.9
Active lever presses in extinction session 6	0.0	0.0	0.1	-0.3	0.0
Delta distance traveled before/after self-admin	0.5	0.5	0.5	-0.7	0.7
Delta ambulatory time before/after self-admin	0.2	0.2	0.4	-0.0	0.6
Time in closed arm before self-admin	1.7	2.0	2.8	-1.7	1.1
Time in closed arm after self-admin	1.2	1.2	2.4	-1.6	0.1
Time in open arm before self-admin	0.3	0.3	0.6	-0.2	-0.8
Time in open arm after self-admin	0.3	0.3	0.6	0.7	-0.0
Sum of active levers in priming session hrs 5-6	0.8	0.8	1.2	1.1	-0.6
Time to tail flick, vehicle, before self-admin	2.2	2.3	3.2	1.1	-1.8
Time to tail flick, vehicle, after self-admin	0.7	0.7	1.1	0.6	-1.1
Time to tail flick, test, before self-admin	0.5	0.5	0.9	-0.9	0.4
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.3	-0.4
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.3	0.3	0.5
Delta time to tail flick, test, before/after SA	0.4	0.3	0.7	0.8	0.0
Ambulatory time before self-admin	1.7	1.8	3.2	0.6	-1.8
Ambulatory time after self-admin	0.3	0.4	0.7	0.1	-0.8
Total heroin consumption	2.7	3.3	3.4	1.8	-1.8
Area under the delay curve	3.2	3.4	5.6	1.1	-2.4
Delay disc. indifference point, 0s delay	2.2	2.4	4.4	0.6	-2.1
Delay disc. indifference point, 16s delay	1.1	1.1	1.7	0.7	-1.3
Delay disc. indifference point, 2s delay	4.8	5.4	7.1	1.9	-2.7
Delay disc. indifference point, 24s delay	1.0	1.0	1.2	0.9	-1.1
Delay disc. indifference point, 4s delay	2.4	2.5	3.5	1.2	-1.9
Delay disc. indifference point, 8s delay	1.2	1.2	2.1	0.6	-1.4
Delay discount exponential model param	3.4	3.6	5.9	-1.2	2.4
Delay discount hyperbolic model param	3.4	3.6	5.6	-1.3	2.4
Fecal boli incidents, locomotor time 1	1.0	1.1	2.1	-1.5	-0.3
Change in fecal boli incidents, locomotor task	0.6	0.5	0.8	0.9	0.5
Time >=10cm from walls, locomotor time 1	2.3	2.3	3.0	1.7	-1.3
Bouts of movement, locomotor time 1	0.9	1.0	2.0	-1.4	0.0
Total resting periods, locomotor time 1	0.7	0.8	1.6	-1.3	-0.2
Rest time, locomotor task time 1	0.3	0.3	0.5	-0.7	-0.1
Distance moved, locomotor task time 1	0.2	0.2	0.3	0.4	-0.5
Vertical activity count, locomotor time 1	0.2	0.3	0.4	-0.6	-0.4
Time >=10cm from walls, locomotor time 2	0.5	0.6	1.2	-0.1	-1.1
Bouts of movement, locomotor time 2	0.9	1.0	2.0	-1.4	0.1
Total resting periods, locomotor time 2	0.8	0.9	1.7	-1.3	0.3
Rest time, locomotor task time 2	0.1	0.2	0.3	0.6	-0.1
Distance moved, locomotor task time 2	0.2	0.2	0.2	-0.5	0.4
Vertical activity count, locomotor time 2	2.0	2.2	3.9	-2.0	0.7
Weight adjusted by age	1.3	1.5	1.7	-1.1	1.3
Seeking ratio, delayed vs. immediate footshock	1.6	1.9	2.1	1.5	1.3
Locomotion in novel chamber	0.4	0.5	1.0	-1.0	0.2
Locomotion in novel chamber post-restriction	2.4	2.8	5.5	-2.3	-0.4
Progressive ratio	0.5	0.6	1.0	1.0	0.5
Food seeking constrained by brief footshock	1.9	2.3	3.9	0.8	2.0
Seeking ratio, punishment vs. effort	0.5	0.6	0.8	-0.9	0.7
Run reversals in cocaine runway, females	0.3	0.3	0.5	0.7	0.3
Run reversals in cocaine runway, males	0.3	0.3	0.4	-0.4	0.7
Latency to leave start box in cocaine runway	0.3	0.3	0.5	0.4	-0.7
Latency to leave start box in cocaine runway, F	0.0	0.0	0.0	-0.1	0.2
Latency to leave start box in cocaine runway, M	0.7	0.7	1.1	0.5	-1.1
Cd content in liver	0.4	0.4	0.6	0.7	0.5
Co content in liver	1.7	2.0	3.2	-0.9	1.8
Cu content in liver	0.2	0.3	0.6	-0.0	0.8
Fe content in liver	1.5	1.8	3.3	-1.8	-0.6
K content in liver	0.0	0.0	0.0	-0.0	-0.1
Mg content in liver	0.2	0.2	0.5	-0.7	0.1
Mn content in liver	0.4	0.5	0.7	0.8	0.6
Na content in liver	0.3	0.3	0.5	-0.2	-0.7
Rb content in liver	1.1	1.4	2.8	1.7	-0.1
Se content in liver	1.2	1.5	2.8	-0.4	-1.7
Sr content in liver	2.0	1.9	3.4	-0.5	1.8
Zn content in liver	3.4	3.8	4.4	-2.1	1.8