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chr3:106,069,409-108,252,074

Trait: Body weight

Best TWAS P=5.951178e-08 · Best GWAS P=1.316817e-07 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	BLA	Mapkbp1	gene expression	ENSRNOG00000007018	0.22	0.11	lasso	26	0.17	2.0e-09	4.0	5.1	2.7e-07	-0.84	0.52	0.48	FALSE
2	BLA	Ehd4	gene expression	ENSRNOG00000007584	0.32	0.23	lasso	5	0.23	1.4e-12	-4.7	5.4	6.0e-08	-0.94	0.32	0.68	TRUE
3	BLA	Sptbn5	mRNA stability	ENSRNOG00000059260	0.11	0.03	top1	1	0.03	8.1e-03	-5.2	5.2	2.6e-07	-0.98	0.07	0.10	FALSE
4	Brain	Ehd4	gene expression	ENSRNOG00000007584	0.32	0.24	lasso	9	0.26	2.1e-24	-5.2	5.2	2.0e-07	-0.96	0.16	0.84	FALSE
5	Brain	Capn3	gene expression	ENSRNOG00000008609	0.04	0.01	blup	1556	0.03	5.7e-04	3.7	5.1	3.2e-07	-0.80	0.56	0.38	FALSE
6	Brain	Mapkbp1	mRNA stability	ENSRNOG00000007018	0.08	0.08	top1	1	0.08	3.9e-08	-5.1	5.1	3.1e-07	-0.96	0.23	0.77	FALSE
7	Brain	Ehd4	mRNA stability	ENSRNOG00000007584	0.10	0.10	top1	1	0.10	2.7e-09	-5.2	5.2	2.3e-07	-0.95	0.16	0.84	FALSE
8	IL	Lrrc57	gene expression	ENSRNOG00000009143	0.39	0.07	top1	1	0.07	8.4e-03	-5.2	5.2	2.6e-07	-0.80	0.09	0.07	FALSE
9	NAcc	Sptbn5	intron excision ratio	chr3:107017004:107017087	0.04	0.02	blup	1444	0.02	9.2e-03	-5.0	5.3	1.4e-07	-0.90	0.38	0.46	FALSE
10	NAcc	Ganc	mRNA stability	ENSRNOG00000024563	0.06	0.02	blup	1589	0.02	1.4e-02	-5.2	5.4	8.1e-08	-0.96	0.30	0.64	FALSE
11	PL	Rpap1	gene expression	ENSRNOG00000005483	0.18	0.12	blup	1494	0.16	2.7e-12	4.8	-5.3	1.2e-07	0.93	0.42	0.58	FALSE
12	PL	Mapkbp1	gene expression	ENSRNOG00000007018	0.17	0.09	lasso	3	0.11	2.1e-08	-5.2	5.3	1.3e-07	-0.92	0.23	0.77	FALSE
13	PL	Ehd4	gene expression	ENSRNOG00000007584	0.43	0.28	top1	1	0.28	3.0e-21	-5.2	5.2	2.1e-07	-0.96	0.14	0.86	FALSE
14	PL	Sptbn5	intron excision ratio	chr3:107014161:107016922	0.05	0.03	blup	1444	0.04	2.3e-04	4.0	-5.2	2.4e-07	0.87	0.50	0.42	FALSE
15	PL	Sptbn5	intron excision ratio	chr3:107017537:107018049	0.08	0.07	top1	1	0.07	8.9e-06	-5.2	5.2	2.1e-07	-0.91	0.13	0.65	FALSE
16	PL	Rpap1	mRNA stability	ENSRNOG00000005483	0.17	0.15	blup	1494	0.17	6.4e-13	-4.7	-5.2	2.2e-07	0.93	0.52	0.48	FALSE
17	PL	Ehd4	mRNA stability	ENSRNOG00000007584	0.05	0.02	lasso	4	0.03	4.3e-03	-4.7	5.1	3.1e-07	-0.82	0.45	0.48	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.