Best TWAS P=5.951178e-08 · Best GWAS P=1.316817e-07 conditioned to 1
# | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | BLA | Mapkbp1 | gene expression | ENSRNOG00000007018 | 0.22 | 0.11 | lasso | 26 | 0.17 | 2.0e-09 | 4.0 | 5.1 | 2.7e-07 | -0.84 | 0.52 | 0.48 | FALSE |
2 | BLA | Ehd4 | gene expression | ENSRNOG00000007584 | 0.32 | 0.23 | lasso | 5 | 0.23 | 1.4e-12 | -4.7 | 5.4 | 6.0e-08 | -0.94 | 0.32 | 0.68 | TRUE |
3 | BLA | Sptbn5 | mRNA stability | ENSRNOG00000059260 | 0.11 | 0.03 | top1 | 1 | 0.03 | 8.1e-03 | -5.2 | 5.2 | 2.6e-07 | -0.98 | 0.07 | 0.10 | FALSE |
4 | Brain | Ehd4 | gene expression | ENSRNOG00000007584 | 0.32 | 0.24 | lasso | 9 | 0.26 | 2.1e-24 | -5.2 | 5.2 | 2.0e-07 | -0.96 | 0.16 | 0.84 | FALSE |
5 | Brain | Capn3 | gene expression | ENSRNOG00000008609 | 0.04 | 0.01 | blup | 1556 | 0.03 | 5.7e-04 | 3.7 | 5.1 | 3.2e-07 | -0.80 | 0.56 | 0.38 | FALSE |
6 | Brain | Mapkbp1 | mRNA stability | ENSRNOG00000007018 | 0.08 | 0.08 | top1 | 1 | 0.08 | 3.9e-08 | -5.1 | 5.1 | 3.1e-07 | -0.96 | 0.23 | 0.77 | FALSE |
7 | Brain | Ehd4 | mRNA stability | ENSRNOG00000007584 | 0.10 | 0.10 | top1 | 1 | 0.10 | 2.7e-09 | -5.2 | 5.2 | 2.3e-07 | -0.95 | 0.16 | 0.84 | FALSE |
8 | IL | Lrrc57 | gene expression | ENSRNOG00000009143 | 0.39 | 0.07 | top1 | 1 | 0.07 | 8.4e-03 | -5.2 | 5.2 | 2.6e-07 | -0.80 | 0.09 | 0.07 | FALSE |
9 | NAcc | Sptbn5 | intron excision ratio | chr3:107017004:107017087 | 0.04 | 0.02 | blup | 1444 | 0.02 | 9.2e-03 | -5.0 | 5.3 | 1.4e-07 | -0.90 | 0.38 | 0.46 | FALSE |
10 | NAcc | Ganc | mRNA stability | ENSRNOG00000024563 | 0.06 | 0.02 | blup | 1589 | 0.02 | 1.4e-02 | -5.2 | 5.4 | 8.1e-08 | -0.96 | 0.30 | 0.64 | FALSE |
11 | PL | Rpap1 | gene expression | ENSRNOG00000005483 | 0.18 | 0.12 | blup | 1494 | 0.16 | 2.7e-12 | 4.8 | -5.3 | 1.2e-07 | 0.93 | 0.42 | 0.58 | FALSE |
12 | PL | Mapkbp1 | gene expression | ENSRNOG00000007018 | 0.17 | 0.09 | lasso | 3 | 0.11 | 2.1e-08 | -5.2 | 5.3 | 1.3e-07 | -0.92 | 0.23 | 0.77 | FALSE |
13 | PL | Ehd4 | gene expression | ENSRNOG00000007584 | 0.43 | 0.28 | top1 | 1 | 0.28 | 3.0e-21 | -5.2 | 5.2 | 2.1e-07 | -0.96 | 0.14 | 0.86 | FALSE |
14 | PL | Sptbn5 | intron excision ratio | chr3:107014161:107016922 | 0.05 | 0.03 | blup | 1444 | 0.04 | 2.3e-04 | 4.0 | -5.2 | 2.4e-07 | 0.87 | 0.50 | 0.42 | FALSE |
15 | PL | Sptbn5 | intron excision ratio | chr3:107017537:107018049 | 0.08 | 0.07 | top1 | 1 | 0.07 | 8.9e-06 | -5.2 | 5.2 | 2.1e-07 | -0.91 | 0.13 | 0.65 | FALSE |
16 | PL | Rpap1 | mRNA stability | ENSRNOG00000005483 | 0.17 | 0.15 | blup | 1494 | 0.17 | 6.4e-13 | -4.7 | -5.2 | 2.2e-07 | 0.93 | 0.52 | 0.48 | FALSE |
17 | PL | Ehd4 | mRNA stability | ENSRNOG00000007584 | 0.05 | 0.02 | lasso | 4 | 0.03 | 4.3e-03 | -4.7 | 5.1 | 3.1e-07 | -0.82 | 0.45 | 0.48 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.