Hub : Traits : Body weight :

chr3:106,069,409-108,252,074

Trait: Body weight

Best TWAS P=5.951178e-08 · Best GWAS P=1.316817e-07 conditioned to 1

Associated models

# Tissue Gene Modality RNA phenotype h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 BLA Mapkbp1 gene expression ENSRNOG00000007018 0.22 0.11 lasso 26 0.17 2.0e-09 4.0 5.1 2.7e-07 -0.84 0.52 0.48 FALSE
2 BLA Ehd4 gene expression ENSRNOG00000007584 0.32 0.23 lasso 5 0.23 1.4e-12 -4.7 5.4 6.0e-08 -0.94 0.32 0.68 TRUE
3 BLA Sptbn5 mRNA stability ENSRNOG00000059260 0.11 0.03 top1 1 0.03 8.1e-03 -5.2 5.2 2.6e-07 -0.98 0.07 0.10 FALSE
4 Brain Ehd4 gene expression ENSRNOG00000007584 0.32 0.24 lasso 9 0.26 2.1e-24 -5.2 5.2 2.0e-07 -0.96 0.16 0.84 FALSE
5 Brain Capn3 gene expression ENSRNOG00000008609 0.04 0.01 blup 1556 0.03 5.7e-04 3.7 5.1 3.2e-07 -0.80 0.56 0.38 FALSE
6 Brain Mapkbp1 mRNA stability ENSRNOG00000007018 0.08 0.08 top1 1 0.08 3.9e-08 -5.1 5.1 3.1e-07 -0.96 0.23 0.77 FALSE
7 Brain Ehd4 mRNA stability ENSRNOG00000007584 0.10 0.10 top1 1 0.10 2.7e-09 -5.2 5.2 2.3e-07 -0.95 0.16 0.84 FALSE
8 IL Lrrc57 gene expression ENSRNOG00000009143 0.39 0.07 top1 1 0.07 8.4e-03 -5.2 5.2 2.6e-07 -0.80 0.09 0.07 FALSE
9 NAcc Sptbn5 intron excision ratio chr3:107017004:107017087 0.04 0.02 blup 1444 0.02 9.2e-03 -5.0 5.3 1.4e-07 -0.90 0.38 0.46 FALSE
10 NAcc Ganc mRNA stability ENSRNOG00000024563 0.06 0.02 blup 1589 0.02 1.4e-02 -5.2 5.4 8.1e-08 -0.96 0.30 0.64 FALSE
11 PL Rpap1 gene expression ENSRNOG00000005483 0.18 0.12 blup 1494 0.16 2.7e-12 4.8 -5.3 1.2e-07 0.93 0.42 0.58 FALSE
12 PL Mapkbp1 gene expression ENSRNOG00000007018 0.17 0.09 lasso 3 0.11 2.1e-08 -5.2 5.3 1.3e-07 -0.92 0.23 0.77 FALSE
13 PL Ehd4 gene expression ENSRNOG00000007584 0.43 0.28 top1 1 0.28 3.0e-21 -5.2 5.2 2.1e-07 -0.96 0.14 0.86 FALSE
14 PL Sptbn5 intron excision ratio chr3:107014161:107016922 0.05 0.03 blup 1444 0.04 2.3e-04 4.0 -5.2 2.4e-07 0.87 0.50 0.42 FALSE
15 PL Sptbn5 intron excision ratio chr3:107017537:107018049 0.08 0.07 top1 1 0.07 8.9e-06 -5.2 5.2 2.1e-07 -0.91 0.13 0.65 FALSE
16 PL Rpap1 mRNA stability ENSRNOG00000005483 0.17 0.15 blup 1494 0.17 6.4e-13 -4.7 -5.2 2.2e-07 0.93 0.52 0.48 FALSE
17 PL Ehd4 mRNA stability ENSRNOG00000007584 0.05 0.02 lasso 4 0.03 4.3e-03 -4.7 5.1 3.1e-07 -0.82 0.45 0.48 FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.