RGD1311703

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	ENSRNOG00000053659	0.07	0.05	2.0e-06	0.04	0.04	0.03	0.04	3.2e-05	2.5e-05	1.3e-04	4.4e-05
2	Brain	gene expression	ENSRNOG00000053659	0.09	0.08	2.1e-06	0.05	0.05	0.05	0.04	2.8e-05	1.3e-05	4.1e-05	5.1e-05
3	NAcc	alternative polyA	ENSRNOT00000090773	0.05	0.05	1.1e-03	0.04	0.04	0.04	0.03	3.4e-04	8.2e-04	8.0e-04	1.5e-03
4	NAcc	alternative polyA	ENSRNOT00000099493	0.05	0.05	1.3e-03	0.03	0.04	0.04	0.03	3.2e-03	9.7e-04	8.4e-04	1.6e-03
5	NAcc	gene expression	ENSRNOG00000053659	0.1	0.09	1.1e-06	0.08	0.08	0.08	0.08	1.9e-06	1.4e-06	9.4e-07	2.3e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
BMI with tail	6.7	21.7	23.8	4.6	4.5	4.5	-4.8	4.9
BMI without tail	11.6	24.3	26.6	4.9	4.9	4.8	-5.0	5.2
Body weight	5.6	23.8	26.6	4.8	4.7	4.7	-5.0	5.2
Epididymis fat weight	1.9	4.4	5.3	2.0	2.0	2.0	-2.2	2.3
Glucose	0.0	0.0	0.0	-0.2	-0.2	-0.1	0.1	-0.2
Heart weight	0.2	0.2	0.3	0.5	0.5	0.3	-0.4	0.5
Left kidney weight	8.1	23.3	24.6	4.8	4.8	4.7	-4.9	5.0
Right kidney weight	9.3	26.4	27.5	5.1	5.1	5.0	-5.2	5.2
Tail length	2.5	7.6	8.5	2.8	2.8	2.6	-2.7	2.9
Length with tail	1.1	4.2	4.9	2.0	2.0	2.0	-2.1	2.2
Length without tail	0.1	0.2	0.2	-0.5	-0.5	-0.3	0.3	-0.4
Liver weight, left	2.9	4.8	5.4	2.2	2.2	2.0	-2.1	2.3
Liver weight, right	4.2	7.0	7.9	2.6	2.6	2.5	-2.7	2.8
Parametrial fat weight	11.2	21.9	23.2	4.6	4.6	4.6	-4.8	4.8
Retroperitoneal fat weight	3.1	10.2	11.1	3.1	3.1	3.1	-3.3	3.3
Intraocular pressure	0.3	0.4	0.4	0.7	0.6	0.7	-0.6	0.5
Extensor digitorum longus weight	2.6	10.3	10.8	3.3	3.3	3.2	-3.1	3.1
Soleus weight	1.2	3.4	3.5	1.9	1.8	1.8	-1.8	1.8
Tibialis anterior weight	4.4	15.2	15.8	3.9	3.9	3.9	-3.9	4.0
Tibia length	0.0	0.1	0.2	0.3	0.3	0.3	-0.4	0.4
Number of licking bursts	6.6	7.8	8.7	-2.7	-2.7	-2.7	2.8	-3.0
Food consumed during 24 hour testing period	0.0	0.0	0.0	0.1	0.1	0.0	-0.1	0.2
Times rat made contact with spout	0.7	0.8	0.9	-0.8	-0.8	-0.9	0.9	-0.9
Mean time between licks in bursts	1.5	2.1	2.5	1.4	1.4	1.4	-1.5	1.6
Mean num. licks in bursts	3.2	3.8	4.5	1.9	1.9	1.8	-2.0	2.1
Std. dev. time between licks in bursts	2.9	3.5	4.1	1.9	1.9	1.8	-1.8	2.0
Water consumed over 24 hours	4.5	5.3	6.1	-2.2	-2.2	-2.4	2.5	-2.3
Indifference point 0 sec	0.0	0.1	0.1	0.3	0.2	0.2	-0.3	0.4
Indifference point AUC	1.2	1.5	1.6	1.2	1.2	1.1	-1.2	1.3
Indifference point function ln k	0.1	0.1	0.2	0.3	0.3	0.4	-0.4	0.3
Indifference point function log k	0.1	0.1	0.2	0.3	0.3	0.4	-0.4	0.3
Delay discounting total patch changes 0 sec	0.2	0.4	0.5	0.6	0.6	0.5	-0.7	0.7
Delay discounting total patch changes 12 sec	0.0	0.1	0.1	-0.2	-0.2	-0.3	0.3	-0.3
Delay discounting total patch changes 18 sec	0.1	0.1	0.2	-0.3	-0.3	-0.4	0.4	-0.3
Delay discounting total patch changes 24 sec	0.4	0.5	0.7	0.8	0.8	0.6	-0.7	0.8
Delay discounting total patch changes 6 sec	0.2	0.3	0.4	-0.5	-0.5	-0.6	0.5	-0.4
Delay discounting time to switch 0 sec	4.5	6.9	7.7	-2.6	-2.6	-2.5	2.7	-2.8
Delay discounting water rate 0 sec	1.0	1.6	1.8	1.2	1.2	1.3	-1.3	1.3
Delay discounting water rate 12 sec	5.8	8.7	9.5	2.8	2.9	2.9	-3.1	3.1
Delay discounting water rate 18 sec	2.8	3.8	4.0	1.9	1.9	1.9	-2.0	2.0
Delay discounting water rate 24 sec	0.4	0.5	0.6	0.7	0.8	0.7	-0.7	0.7
Delay discounting water rate 6 sec	0.6	0.8	1.0	0.8	0.9	0.9	-1.0	0.9
Locomotor activity	0.6	1.0	1.4	0.9	0.9	1.0	-1.2	1.1
Locomotor testing distance	0.2	0.3	0.6	0.4	0.4	0.6	-0.8	0.6
Locomotor testing rearing	0.1	0.2	0.3	0.4	0.4	0.5	-0.6	0.5
Light reinforcement 1	0.7	1.3	1.5	-1.1	-1.1	-1.2	1.2	-1.1
Light reinforcement 2	0.3	0.4	0.5	-0.6	-0.6	-0.7	0.6	-0.5
Reaction time number correct	0.3	0.4	0.5	0.7	0.6	0.7	-0.6	0.6
Reaction time mean minus median	0.7	0.9	1.0	1.0	1.0	0.9	-1.0	1.0
Reaction time mean minus median AUC	1.1	1.4	1.5	1.1	1.1	1.1	-1.2	1.2
Reaction time num false alarms	0.3	0.4	0.6	-0.5	-0.5	-0.6	0.7	-0.8
Reaction time num false alarms AUC	0.1	0.1	0.2	-0.2	-0.2	-0.3	0.4	-0.4
Reaction time trials correct on left	0.3	0.4	0.5	0.7	0.6	0.7	-0.6	0.6
Reaction time trials on left	0.3	0.5	0.5	0.7	0.7	0.7	-0.7	0.6
Reaction time mean	0.2	0.2	0.3	0.4	0.4	0.5	-0.5	0.5
Reaction time mean AUC	0.1	0.1	0.1	0.3	0.3	0.3	-0.3	0.4
Median of all reaction times	0.0	0.0	0.0	0.1	0.1	0.1	-0.2	0.2
Reaction time omissions	0.0	0.1	0.1	0.2	0.2	0.2	-0.3	0.3
Reaction time false alarm rate	0.4	0.6	0.7	-0.7	-0.7	-0.7	0.8	-0.9
Reaction time premature initiation rate	0.0	0.0	0.1	0.2	0.2	0.3	-0.2	0.1
Reaction time premature initiations	0.1	0.1	0.2	0.4	0.4	0.5	-0.3	0.2
Std. dev. reaction times	0.8	1.2	1.3	1.0	1.0	1.0	-1.1	1.2
Reaction time trials completed	0.3	0.5	0.5	0.7	0.7	0.7	-0.7	0.6
Reaction time trials AUC	0.4	0.6	0.7	0.8	0.8	0.8	-0.8	0.8
Social response proportion	1.1	1.2	1.5	1.0	1.0	1.0	-1.2	1.2
Social responses	0.3	0.4	0.5	-0.7	-0.7	-0.7	0.6	-0.6
Social time	0.2	0.3	0.4	-0.6	-0.6	-0.4	0.4	-0.5
Conditioned locomotion	0.2	0.2	0.2	-0.5	-0.5	-0.5	0.5	-0.5
Cocaine response after cond. corrected	0.6	0.6	0.7	-0.8	-0.8	-0.7	0.8	-0.8
Cocaine response after cond. not corrected	0.4	0.4	0.5	0.7	0.7	0.7	-0.6	0.6
Cocaine response before conditioning	5.8	7.1	7.3	2.7	2.7	2.6	-2.6	2.7
Saline control response	0.5	0.7	0.8	0.8	0.8	0.8	-0.8	0.9
Condit. Reinf. active minus inactive responses	1.6	1.9	2.4	1.3	1.3	1.3	-1.5	1.6
Condit. Reinf. active-inactive response ratio	0.7	0.8	1.0	0.8	0.9	0.8	-0.9	1.0
Condit. Reinf. active responses	1.5	2.1	2.5	1.3	1.3	1.4	-1.6	1.6
Condit. Reinf. inactive responses	1.1	1.3	1.5	1.1	1.1	1.2	-1.2	1.1
Condit. Reinf. lever presses	3.9	5.4	6.1	2.2	2.2	2.2	-2.4	2.5
Condit. Reinf. lever reinforcers received	1.2	1.7	2.0	1.2	1.2	1.3	-1.4	1.4
Pavlov. Cond. lever latency	2.0	2.7	3.3	-1.6	-1.6	-1.5	1.7	-1.8
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.1	0.1	-0.0	0.1	-0.1
Pavlov. Cond. change in total contacts	0.6	0.8	1.2	0.8	0.8	0.8	-1.0	1.1
Pavlov. Cond. index score	0.6	0.8	0.9	0.9	0.9	0.8	-0.9	1.0
Pavlov. Cond. latency score	0.5	0.7	0.7	0.8	0.8	0.8	-0.8	0.9
Pavlov. Cond. lever contacts	3.7	5.2	5.9	2.2	2.2	2.2	-2.4	2.4
Pavlov. Cond. magazine entry number	0.4	0.5	0.6	0.7	0.7	0.7	-0.8	0.7
Pavlov. Cond. intertrial magazine entries	8.4	10.8	11.6	3.2	3.2	3.3	-3.4	3.4
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.8	0.8	0.8	0.7	-0.8	0.9
Pavlov. Cond. response bias	1.4	2.0	2.4	1.4	1.4	1.3	-1.5	1.6
Conditioned reinforcement - actives	0.3	0.3	0.4	-0.7	-0.7	0.5	-0.1	-0.6
Conditioned reinforcement - inactives	0.7	0.8	1.2	-1.1	-1.1	-0.4	0.7	-1.0
Conditioned locomotion	0.8	0.9	1.5	-1.2	-1.2	-0.2	0.5	-1.2
Intermittent access intake day 1-15 change	0.6	0.6	1.1	-0.9	-0.9	-0.2	0.5	-1.0
Intermittent access intake escalation	0.4	0.4	0.7	-0.7	-0.7	-0.0	0.3	-0.8
Intermittent access intake escalation 2	0.1	0.1	0.3	-0.4	-0.4	0.1	0.2	-0.5
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.2	-0.3	-0.3	-0.1	0.2	-0.4
Intermitt. access day 15 inactive lever presses	0.8	0.8	1.5	-0.7	-0.7	-1.2	1.0	-0.8
Intermitt. access escalation Index	1.6	1.5	2.4	1.6	1.6	-0.4	-0.2	1.5
Intermittent access day 1 total infusions	0.6	0.6	1.2	0.5	0.5	1.1	-1.0	0.6
Intermittent access day 15 total infusions	0.4	0.4	1.4	0.0	0.0	1.2	-0.9	-0.0
Intermittent access terminal intake (last 3 days)	0.6	0.7	2.0	0.3	0.3	1.4	-1.1	0.2
Intermittent access total infusions	0.5	0.6	1.4	0.4	0.4	1.2	-1.0	0.5
Intermittent access day 1 locomotion	1.7	1.8	3.2	0.9	0.9	1.8	-1.7	1.1
Intermittent access day 15 total locomotion	0.6	0.6	1.0	0.6	0.6	0.9	-1.0	0.7
Intermittent access total locomotion	1.4	1.6	2.4	0.9	1.0	1.5	-1.6	1.1
Intermittent access standard deviation	0.4	0.4	0.5	0.7	0.7	0.7	-0.6	0.6
Cocaine induced anxiety	1.1	1.3	1.8	1.2	1.2	0.8	-1.0	1.3
Post-drug Anxiety	0.3	0.3	0.5	0.7	0.7	0.2	-0.4	0.7
Baseline Anxiety	1.6	1.7	2.3	-1.3	-1.3	-1.1	1.3	-1.5
Lifetime Intake	0.6	0.7	1.0	0.7	0.7	1.0	-1.0	0.8
Incentive Sensitization - Responses	0.7	0.7	0.9	-0.8	-0.8	-0.9	0.9	-0.7
Incentive Sensitization - Breakpoint	0.7	0.7	0.9	-0.8	-0.8	-1.0	0.9	-0.7
Progressive ratio test 1 active lever presses	0.4	0.4	0.6	0.4	0.4	0.8	-0.7	0.7
Progressive ratio test 1 breakpoint	0.5	0.5	0.7	0.5	0.5	0.8	-0.8	0.8
Progressive ratio test 1 inactive lever presses	0.4	0.4	0.9	0.6	0.6	0.5	-0.6	1.0
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	-0.1	-0.1	0.3	-0.3	0.2
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	0.0	0.0	0.2	-0.2	0.3
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.1	-0.0
Total sessions with >9 infusions	1.0	1.1	1.9	0.7	0.7	1.4	-1.3	0.9
Short access day 1 total inactive lever presses	0.1	0.1	0.2	-0.5	-0.5	-0.2	0.2	-0.3
Short access day 10 total inactive lever presses	1.5	1.7	3.4	-0.9	-0.9	-1.9	1.6	-0.9
Short access day 1 total infusions	0.3	0.3	0.6	0.5	0.5	0.5	-0.6	0.8
Short access day 10 total infusions	0.3	0.3	0.7	0.3	0.3	0.8	-0.7	0.4
Short access total infusions	0.9	1.0	1.6	1.0	1.0	0.7	-0.9	1.3
Short access day 1 locomotion	0.1	0.1	0.2	-0.3	-0.3	0.5	-0.3	-0.2
Short access day 10 total locomotion	2.6	2.8	3.6	1.4	1.4	1.9	-1.9	1.7
Short access total locomotion	3.3	3.4	5.7	1.4	1.4	2.4	-2.3	1.6
Compulsive drug intake	1.9	1.8	2.0	1.4	1.4	1.3	-1.4	1.4
One hour access (0.3 mA shock)	2.1	2.5	3.7	1.3	1.3	1.9	-1.8	1.3
One hour access (shock baseline)	0.1	0.1	0.2	-0.4	-0.4	0.3	-0.1	-0.4
Number of responses in last shaping day	0.0	0.0	0.0	0.1	0.1	0.0	-0.0	0.2
Context. condit. distance diff. score	0.6	0.7	0.9	-1.0	-1.0	-0.7	0.7	-0.9
Locomotion velocity, session 1	3.7	4.0	4.5	-1.9	-1.9	-2.1	2.1	-2.0
Locomotion distance, session 1	0.0	0.0	0.1	-0.2	-0.3	-0.3	0.1	-0.1
Locomotion velocity, session 2	4.5	5.3	6.0	-2.2	-2.2	-2.4	2.5	-2.3
Locomotion distance, session 2	0.0	0.1	0.1	-0.2	-0.3	-0.3	0.2	-0.2
Locomotion velocity, session 3	0.0	0.0	0.0	0.0	-0.0	-0.2	0.1	0.0
Locomotion distance, session 3	0.0	0.0	0.1	0.0	0.0	0.3	-0.1	-0.1
Stereotopy head waving bouts, day 3	1.5	1.8	2.3	-1.3	-1.3	-1.5	1.4	-1.2
Stereotopy head waving duration, day 3	2.0	2.4	3.0	-1.5	-1.5	-1.7	1.6	-1.4
Locomotion velocity, session 7	0.2	0.2	0.3	-0.4	-0.4	-0.5	0.6	-0.6
Locomotion distance, session 7	0.8	1.0	1.4	-1.0	-1.0	-0.8	1.0	-1.2
Stereotopy head waving bouts, day 7	0.4	0.5	0.6	-0.7	-0.7	-0.8	0.7	-0.6
Stereotopy head waving duration, day 7	0.1	0.2	0.3	0.4	0.4	0.3	-0.5	0.5
Locomotion velocity, session 8	1.6	1.9	2.2	-1.4	-1.4	-1.3	1.3	-1.5
Locomotion distance, session 8	0.9	1.3	1.5	-1.2	-1.2	-1.1	1.0	-1.1
Degree of sensitization distance	0.5	0.5	0.6	-0.8	-0.7	-0.6	0.6	-0.7
Degree of sensitization stereotypy	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.1	-0.1
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	0.4	0.4	0.4	-0.5	0.5
Condit. Reinf. active-inactive response ratio	0.9	1.0	1.2	1.0	1.0	0.9	-1.0	1.1
Condit. Reinf. active responses	0.0	0.0	0.0	0.2	0.1	0.1	-0.1	0.2
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.2	0.2	0.1	-0.1	0.2
Incentive salience index mean	0.3	0.4	0.4	0.7	0.7	0.6	-0.6	0.6
Condit. Reinf. lever presses	0.0	0.0	0.0	0.1	0.1	0.1	-0.0	-0.0
Time in familiar zone, hab. session 1	0.3	0.3	0.3	-0.5	-0.5	-0.5	0.5	-0.5
Time in novel zone, hab. session 1	0.2	0.2	0.2	0.4	0.4	0.4	-0.4	0.5
Total zone transitions, hab. session 1	0.2	0.2	0.4	0.4	0.4	0.5	-0.6	0.5
Total locomotion distance, hab. session 1	0.6	0.9	1.3	0.8	0.8	0.9	-1.1	1.1
Locomotion velocity, hab. session 1	0.7	1.0	1.4	0.9	0.9	0.9	-1.2	1.1
Time in familiar zone, hab. session 2	0.5	0.6	0.7	0.7	0.7	0.8	-0.8	0.8
Time in novel zone, hab. session 2	0.0	0.0	0.0	-0.0	-0.1	-0.1	0.1	-0.1
Total zone transitions, hab. session 2	0.3	0.4	0.6	0.6	0.5	0.6	-0.8	0.8
Total locomotion distance, hab. session 2	0.1	0.1	0.1	0.2	0.2	0.2	-0.3	0.4
Locomotion velocity, hab. session 2	0.1	0.1	0.2	0.2	0.2	0.2	-0.4	0.4
Novel to familiar place preference ratio	0.2	0.2	0.2	-0.5	-0.5	-0.5	0.4	-0.4
Novelty place preference	0.4	0.4	0.5	-0.7	-0.7	-0.7	0.6	-0.6
Time in novel zone, NPP test	0.3	0.3	0.3	-0.6	-0.6	-0.6	0.4	-0.4
Total zone transitions, NPP test	0.0	0.1	0.1	0.2	0.2	0.2	-0.3	0.3
Total locomotion distance, NPP test	0.0	0.1	0.1	-0.2	-0.2	-0.2	0.2	-0.2
Locomotion velocity, NPP test	0.0	0.0	0.0	-0.2	-0.2	-0.2	0.2	-0.2
Pavlov. Cond. lever latency	1.7	2.2	2.4	-1.5	-1.5	-1.5	1.5	-1.4
Pavlov. Cond. magazine entry latency	7.0	9.1	9.4	3.0	3.0	3.0	-3.1	3.0
Pavlov. Cond. change in total contacts	2.5	2.6	3.1	1.6	1.7	1.8	-1.6	1.5
Pavlov. Cond. index score	5.2	6.6	6.9	2.6	2.6	2.6	-2.6	2.5
Pavlov. Cond. latency score	4.9	6.3	6.5	2.5	2.5	2.5	-2.5	2.5
Pavlov. Cond. lever contacts	3.3	3.9	4.2	2.0	2.0	2.1	-2.0	1.9
Pavlov. Cond. magazine entry number	4.3	5.3	5.4	-2.3	-2.3	-2.3	2.3	-2.3
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.4	-0.7	-0.7	-0.6	0.6	-0.6
Pavlov. Cond. lever-magazine prob. diff.	5.9	7.4	7.8	2.7	2.7	2.8	-2.7	2.7
Pavlov. Cond. response bias	3.6	4.4	4.7	2.1	2.1	2.2	-2.1	2.0
Bone: apparent density	0.5	0.8	0.9	0.9	0.9	0.9	-0.9	1.0
Bone surface	0.7	1.3	1.4	1.1	1.1	1.1	-1.1	1.2
Bone volume	0.8	1.4	1.6	1.2	1.2	1.1	-1.2	1.3
Bone: connectivity density	0.8	1.2	1.3	1.1	1.1	1.1	-1.1	1.1
Bone: cortical apparent density	2.7	3.6	4.3	-1.7	-1.7	-1.9	2.0	-2.1
Bone: cortical area	1.6	2.5	2.8	1.6	1.6	1.5	-1.6	1.7
Bone: cortical porosity	2.6	2.8	3.1	1.6	1.6	1.7	-1.8	1.6
Bone: cortical porosity	1.3	1.4	1.6	1.2	1.1	1.2	-1.3	1.2
Bone: cortical thickness	0.0	0.1	0.1	0.3	0.3	0.3	-0.3	0.2
Bone: cortical thickness	0.1	0.1	0.2	-0.4	-0.4	-0.2	0.3	-0.4
Bone: cortical tissue density	2.8	3.6	4.3	-1.8	-1.8	-1.9	2.0	-2.1
Bone: elastic displacement	3.7	4.2	4.4	-2.1	-2.1	-2.0	2.0	-2.1
Bone: elastic work	0.3	0.4	0.5	-0.7	-0.7	-0.6	0.6	-0.7
Bone: endosteal estimation	1.5	3.3	4.3	1.8	1.8	1.7	-1.7	2.1
Bone: endosteal perimeter	0.9	1.8	2.2	1.3	1.3	1.3	-1.3	1.5
Bone: final force	1.6	2.7	3.2	1.7	1.6	1.5	-1.6	1.8
Bone: final moment	1.3	2.1	2.7	1.5	1.5	1.3	-1.5	1.6
Bone: marrow area	1.4	3.0	4.0	1.7	1.7	1.6	-1.7	2.0
Bone: maximum diameter	2.3	4.2	4.9	2.0	2.0	2.0	-2.0	2.2
Bone: maximum force	1.3	2.3	2.8	1.5	1.5	1.3	-1.5	1.7
Bone: maximum moment	1.0	1.7	2.3	1.3	1.3	1.1	-1.3	1.5
Bone: minimum diameter	0.6	1.1	1.5	1.0	1.0	1.0	-1.0	1.2
Bone: periosteal estimation	2.0	4.0	5.0	2.0	2.0	1.9	-1.9	2.2
Bone: periosteal perimeter	2.3	3.7	4.5	1.9	1.9	1.8	-1.9	2.1
Bone: post-yield work	5.0	6.9	8.4	2.5	2.5	2.5	-2.7	2.9
Bone: stiffness	0.8	1.3	1.5	1.2	1.2	1.0	-1.1	1.2
Bone: tissue strength	0.1	0.1	0.2	-0.3	-0.3	-0.5	0.4	-0.3
Bone: trabecular number	0.0	0.0	0.0	0.1	0.0	0.1	-0.1	0.1
Bone: trabecular spacing	0.3	0.4	0.4	0.6	0.6	0.6	-0.6	0.6
Bone: trabecular thickness	0.9	1.1	1.4	1.0	0.9	0.9	-1.1	1.2
Bone: trabecular tissue density	0.3	0.5	0.6	-0.6	-0.6	-0.7	0.7	-0.8
Breakpoint value in progressive ratio session	4.6	5.1	5.5	-2.3	-2.3	-2.2	2.2	-2.4
Distance traveled before self-admin	0.9	1.0	1.4	-1.1	-1.1	-0.7	0.9	-1.2
Distance traveled after self-admin	0.1	0.1	0.2	-0.0	-0.0	0.5	-0.2	-0.1
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.4	-0.4	0.1	0.2	-0.5
Delta time in open arm before/after self-admin	3.8	3.6	4.2	1.7	1.7	2.0	-2.1	1.9
Diff in mean of infusions in LGA sessions	0.6	0.6	1.0	-0.7	-0.7	-1.0	0.8	-0.6
Extinction: sum of active levers before priming	0.4	0.4	0.5	-0.5	-0.6	-0.7	0.7	-0.6
Active lever presses in extinction session 6	0.3	0.3	0.5	0.4	0.4	0.7	-0.7	0.5
Delta distance traveled before/after self-admin	1.2	1.3	1.7	1.0	1.0	1.3	-1.2	1.1
Delta ambulatory time before/after self-admin	0.6	0.6	0.8	0.7	0.7	0.9	-0.9	0.8
Time in closed arm before self-admin	0.8	0.9	1.1	0.9	0.9	0.9	-1.1	1.0
Time in closed arm after self-admin	0.4	0.5	0.8	-0.9	-0.9	-0.1	0.3	-0.9
Time in open arm before self-admin	1.2	1.3	2.4	-0.8	-0.8	-1.5	1.4	-0.9
Time in open arm after self-admin	2.5	2.8	2.9	1.6	1.6	1.7	-1.7	1.7
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.1	0.1	-0.4	0.2	0.2
Time to tail flick, vehicle, before self-admin	0.8	0.9	0.9	0.9	0.9	0.9	-1.0	0.9
Time to tail flick, vehicle, after self-admin	0.5	0.5	0.8	-0.9	-0.9	-0.2	0.4	-0.9
Time to tail flick, test, before self-admin	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.0	-0.1
Time to tail flick, test, after self-admin	0.2	0.2	0.6	0.1	0.1	0.8	-0.5	0.0
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.4	-0.3	-0.3	-0.6	0.5	-0.3
Delta time to tail flick, test, before/after SA	0.6	0.6	1.0	0.6	0.6	1.0	-0.9	0.5
Ambulatory time before self-admin	1.6	1.7	2.5	-1.5	-1.5	-0.8	1.1	-1.6
Ambulatory time after self-admin	0.2	0.2	0.4	-0.5	-0.5	0.3	0.0	-0.6
Total heroin consumption	1.9	2.3	3.2	-1.4	-1.4	-1.8	1.6	-1.3
Area under the delay curve	0.5	0.6	0.7	-0.7	-0.7	-0.8	0.8	-0.7
Delay disc. indifference point, 0s delay	0.2	0.2	0.2	-0.4	-0.4	-0.4	0.5	-0.3
Delay disc. indifference point, 16s delay	5.1	5.2	5.5	-2.2	-2.2	-2.3	2.3	-2.2
Delay disc. indifference point, 2s delay	0.5	0.5	0.7	0.7	0.7	0.7	-0.7	0.8
Delay disc. indifference point, 24s delay	2.8	2.7	3.2	-1.5	-1.5	-1.7	1.8	-1.6
Delay disc. indifference point, 4s delay	0.6	0.6	0.7	-0.8	-0.8	-0.8	0.8	-0.7
Delay disc. indifference point, 8s delay	1.3	1.4	1.4	-1.2	-1.2	-1.1	1.2	-1.2
Delay discount exponential model param	0.5	0.5	0.6	0.7	0.7	0.8	-0.8	0.7
Delay discount hyperbolic model param	0.4	0.4	0.5	0.6	0.6	0.7	-0.7	0.5
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	-0.2	-0.3	-0.4	0.4	-0.3
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.0	-0.0
Time >=10cm from walls, locomotor time 1	0.6	0.7	0.8	-0.9	-0.9	-0.7	0.7	-0.8
Bouts of movement, locomotor time 1	0.0	0.0	0.0	-0.1	-0.1	-0.2	0.2	-0.2
Total resting periods, locomotor time 1	0.4	0.4	0.5	-0.6	-0.6	-0.6	0.7	-0.7
Rest time, locomotor task time 1	4.5	4.9	6.1	-2.1	-2.1	-2.0	2.3	-2.5
Distance moved, locomotor task time 1	2.4	2.7	3.4	1.5	1.5	1.5	-1.8	1.8
Vertical activity count, locomotor time 1	0.1	0.1	0.2	0.4	0.3	0.3	-0.4	0.5
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.2	0.4	0.4	0.5	-0.5	0.3
Bouts of movement, locomotor time 2	0.5	0.6	0.7	0.8	0.7	0.8	-0.8	0.7
Total resting periods, locomotor time 2	0.8	0.8	0.9	0.9	0.9	0.9	-0.9	0.9
Rest time, locomotor task time 2	1.2	1.4	1.5	-1.2	-1.2	-1.1	1.2	-1.2
Distance moved, locomotor task time 2	0.0	0.0	0.0	-0.2	-0.2	-0.1	0.2	-0.2
Vertical activity count, locomotor time 2	0.9	0.9	1.1	-0.9	-0.9	-1.0	1.0	-1.0
Weight adjusted by age	0.8	1.0	1.6	1.1	1.1	0.3	-0.7	1.3
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.3	0.2	0.2	0.5	-0.4	0.1
Locomotion in novel chamber	5.0	6.2	7.2	2.6	2.6	2.1	-2.4	2.7
Locomotion in novel chamber post-restriction	0.3	0.4	0.8	0.7	0.7	0.2	-0.5	0.9
Progressive ratio	0.2	0.3	0.8	0.0	0.0	0.9	-0.7	0.3
Food seeking constrained by brief footshock	0.3	0.4	0.7	-0.8	-0.8	0.4	0.0	-0.8
Seeking ratio, punishment vs. effort	0.0	0.0	0.0	0.1	0.0	-0.0	0.1	-0.1
Run reversals in cocaine runway, females	1.4	1.4	2.1	1.3	1.3	0.9	-0.9	1.5
Run reversals in cocaine runway, males	2.8	2.7	2.9	-1.6	-1.6	-1.6	1.6	-1.7
Latency to leave start box in cocaine runway	0.1	0.1	0.2	-0.4	-0.4	-0.1	0.2	-0.4
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	0.3	0.3	-0.5	0.2	0.2
Latency to leave start box in cocaine runway, M	1.7	1.6	2.3	-1.5	-1.5	-0.7	1.0	-1.5
Cd content in liver	1.0	1.0	1.1	-1.0	-1.0	-1.0	1.0	-1.0
Co content in liver	1.6	1.9	2.0	-1.4	-1.4	-1.4	1.4	-1.3
Cu content in liver	0.3	0.3	0.4	0.4	0.4	0.5	-0.7	0.7
Fe content in liver	1.7	2.1	2.3	-1.4	-1.4	-1.4	1.5	-1.5
K content in liver	1.6	1.6	1.8	1.3	1.3	1.2	-1.3	1.4
Mg content in liver	0.9	0.9	1.1	0.9	0.9	0.9	-1.0	1.1
Mn content in liver	0.9	1.1	1.1	1.1	1.1	1.0	-1.0	1.0
Na content in liver	1.5	1.6	1.8	1.3	1.3	1.2	-1.2	1.3
Rb content in liver	0.2	0.2	0.3	0.3	0.3	0.4	-0.5	0.6
Se content in liver	0.4	0.5	0.5	0.7	0.7	0.7	-0.7	0.7
Sr content in liver	2.3	2.1	2.2	1.5	1.5	1.4	-1.4	1.5
Zn content in liver	1.4	1.5	1.8	1.1	1.1	1.2	-1.3	1.4