Best TWAS P = 7.94e-11 · Best GWAS P= 5.44e-10 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLA | LOC134479728 | gene expression | LOC134479728 | 0.1 | 92 | -0 | 7.8e-01 | 6.04 | 1.56e-09 | 0.23 | FALSE |
| Brain | LOC134479904 | gene expression | LOC134479904 | 0.13 | 36 | 0.13 | 4.0e-12 | -5.91 | 3.35e-09 | 0.2 | TRUE |
| IC | LOC134479904 | gene expression | LOC134479904 | 0.69 | 1873 | 0.45 | 7.9e-21 | -6.12 | 9.61e-10 | 0.4 | TRUE |
| IC | Med30 | isoform ratio | NM_001130539.2 | 0.1 | 1969 | 0.07 | 5.4e-04 | 6.17 | 6.62e-10 | 0.14 | FALSE |
| IC | Med30 | isoform ratio | NM_001399687.1 | 0.11 | 1969 | 0.08 | 4.1e-04 | -6.19 | 5.87e-10 | 0.14 | FALSE |
| IC | Ext1 | mRNA stability | Ext1 | 0.67 | 1873 | 0.45 | 7.0e-21 | 6.1 | 1.03e-09 | 0.4 | FALSE |
| IL | LOC134479728 | gene expression | LOC134479728 | 0.25 | 26 | 0.04 | 3.7e-02 | 6.15 | 7.57e-10 | 0.2 | FALSE |
| IL | LOC134479904 | gene expression | LOC134479904 | 0.25 | 1873 | 0.06 | 1.7e-02 | -6.03 | 1.66e-09 | 0.19 | FALSE |
| Liver | LOC102548590 | gene expression | LOC102548590 | 0.49 | 1 | 0.37 | 5.0e-43 | -6.01 | 1.87e-09 | 0.9 | TRUE |
| Liver | Med30 | intron excision ratio | chr7_85901967_85905130 | 0.07 | 68 | 0.03 | 2.8e-04 | -6.1 | 1.09e-09 | 0.67 | FALSE |
| Liver | Med30 | intron excision ratio | chr7_85905234_85916008 | 0.1 | 5 | 0.04 | 2.7e-05 | 6.31 | 2.82e-10 | 0.74 | TRUE |
| NAcc | Ext1 | gene expression | Ext1 | 0.04 | 1873 | 0.03 | 5.0e-06 | -6.1 | 1.07e-09 | 0.26 | FALSE |
| NAcc | LOC134479728 | gene expression | LOC134479728 | 0.08 | 1696 | 0.07 | 5.2e-11 | 6.16 | 7.49e-10 | 0.28 | FALSE |
| OFC | Med30 | gene expression | Med30 | 0.23 | 39 | 0.2 | 1.5e-05 | -5.48 | 4.25e-08 | 0.1 | FALSE |
| OFC | Med30 | isoform ratio | NM_001130539.2 | 0.15 | 233 | 0.09 | 4.5e-03 | 6.43 | 1.31e-10 | 0.08 | TRUE |
| OFC | Med30 | isoform ratio | NM_001399687.1 | 0.16 | 1969 | 0.07 | 9.8e-03 | -5.25 | 1.52e-07 | 0.08 | TRUE |
| OFC | Ext1 | mRNA stability | Ext1 | 0.44 | 377 | 0.22 | 6.0e-06 | 5.97 | 2.39e-09 | 0.58 | FALSE |
| PL | LOC134479728 | gene expression | LOC134479728 | 0.12 | 1696 | 0.12 | 6.5e-13 | 6.5 | 7.94e-11 | 0.26 | TRUE |
| PL | LOC134479904 | gene expression | LOC134479904 | 0.4 | 40 | 0.34 | 1.1e-38 | -5.56 | 2.73e-08 | 0.26 | FALSE |
| PL | Med30 | isoform ratio | NM_001130539.2 | 0.07 | 19 | 0.05 | 4.2e-06 | 6.43 | 1.26e-10 | 0.14 | FALSE |
| PL | Med30 | isoform ratio | NM_001399687.1 | 0.07 | 18 | 0.05 | 2.9e-06 | -6.45 | 1.08e-10 | 0.15 | FALSE |
| PL | Ext1 | mRNA stability | Ext1 | 0.48 | 61 | 0.43 | 1.9e-51 | 5.66 | 1.55e-08 | 0.25 | FALSE |
| pVTA | LOC134479728 | gene expression | LOC134479728 | 0.11 | 1696 | 0.09 | 5.4e-08 | 6.1 | 1.04e-09 | 0.27 | FALSE |
| pVTA | Med30 | gene expression | Med30 | 0.21 | 157 | 0.08 | 8.9e-07 | -5.94 | 2.80e-09 | 0.69 | FALSE |
| pVTA | Med30 | intron excision ratio | chr7_85901967_85916008 | 0.06 | 53 | 0.04 | 2.8e-04 | 5.8 | 6.83e-09 | 0.18 | FALSE |