Hub : Traits

Bone: cortical thickness

Tags: Physiology · Bone

Project: r01_doug_adams

8 loci · 22 genes with independent associations · 79 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr3	146614418	148660154	45	5	1.77e-08	1.75e-08	1e+00	Esf1 Ndufaf5
2	chr8	117463629	118343328	1	1	1.69e-34	1.52e-02	1e+00	Mst1
3	chr8	130995414	132376607	1	1	1.89e-09	7.72e-02	1e+00	Clec3b
4	chr9	83390749	84777604	1	1	4.07e-137	8.07e-01	1e+00	Retreg2
5	chr10	90948870	92930304	3	1	5.06e-08	1.81e-07	1e+00	Cep95
6	chr10	95109047	99430546	11	5	2.18e-12	9.13e-12	NaN	Abca5 LOC102549521 LOC102549836 LOC134480721 LOC134480722
7	chr10	103498083	105333696	13	5	1.60e-08	1.45e-08	1e+00	Cyth1 LOC134480909 Usp36
8	chr10	106013117	107706829	4	3	4.85e-08	2.08e-08	1e+00	Fn3k Hexd Slc16a3

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	28.98	10	1	4.5	0.86	2.21e-11	Cyth1 Esf1 Ism1 LOC134480909 Ndufaf5 Retreg2 Sptlc3 Tasp1 Timp2 Usp36
BMI without tail	5208.33	5	1	4.5	-0.78	4.32e-03	Esf1 Ndufaf5 Retreg2 Sptlc3 Tasp1
Body weight	5.31	11	5	22.7	0.86	1.04e-28	Esf1 Ism1 Mst1 Ndufaf5 Rab40b Retreg2 Slc16a3 Sptlc3 Tasp1 Timp2 Usp36
Epididymis fat weight	4037.48	6	2	9.1	-0.76	1.70e-02	Esf1 Mst1 Ndufaf5 Retreg2 Sptlc3 Tasp1
Glucose	227.24	3	2	9.1	0	1.00e+00	Fn3k Mst1 Retreg2
Heart weight	3065.65	1	1	4.5	0	1.00e+00	Retreg2
Left kidney weight	55046.11	1	1	4.5	0	1.00e+00	Retreg2
Right kidney weight	20208.48	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Tail length	28919.24	1	1	4.5	0	1.00e+00	Retreg2
Length with tail	747.9	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Length without tail	9451.88	4	2	9.1	0.84	7.57e-02	Mst1 Retreg2 Timp2 Usp36
Liver weight, left	1755.51	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Liver weight, right	35.63	3	3	13.6	0	1.00e+00	Clec3b Mst1 Retreg2
Parametrial fat weight	181.56	1	1	4.5	0	1.00e+00	Retreg2
Retroperitoneal fat weight	50.55	7	6	27.3	-0.14	1.83e-01	Esf1 Ism1 Mst1 Ndufaf5 Retreg2 Sptlc3 Tasp1
Intraocular pressure	10386.52	1	1	4.5	0	1.00e+00	Retreg2
Extensor digitorum longus weight	541.05	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Soleus weight	20.71	1	1	4.5	0	1.00e+00	Retreg2
Tibialis anterior weight	1158.38	1	1	4.5	0	1.00e+00	Retreg2
Tibia length	14.27	12	6	27.3	0.27	8.32e-03	Esf1 Fn3k Ism1 Mst1 Ndufaf5 Rab40b Retreg2 Slc16a3 Sptlc3 Tasp1 Timp2 Usp36
Number of licking bursts	67424.86	1	1	4.5	0	1.00e+00	Retreg2
Food consumed during 24 hour testing period	17761.06	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Times rat made contact with spout	71.66	1	1	4.5	0	1.00e+00	Retreg2
Mean time between licks in bursts	111630.35	1	1	4.5	0	1.00e+00	Retreg2
Mean num. licks in bursts	56750.08	1	1	4.5	0	1.00e+00	Retreg2
Std. dev. time between licks in bursts	9924.24	3	1	4.5	0	1.00e+00	Clec3b Mst1 Retreg2
Water consumed over 24 hours	34168.6	1	1	4.5	0	1.00e+00	Retreg2
Patch foraging indifference point 0 sec	19591.07	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Patch foraging indifference point AUC	25114.54	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Indifference point function ln k	27906.36	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Indifference point function log k	27906.36	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Patch foraging total patch changes 0 sec	20977.37	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Patch foraging total patch changes 12 sec	1182.87	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Patch foraging total patch changes 18 sec	10122.56	4	2	9.1	-0.92	7.84e-02	Mst1 Retreg2 Sptlc3 Tasp1
Patch foraging total patch changes 24 sec	37424.62	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Patch foraging total patch changes 6 sec	7787.09	1	1	4.5	0	1.00e+00	Retreg2
Patch foraging time to switch 0 sec	66489.31	1	1	4.5	0	1.00e+00	Retreg2
Patch foraging water rate 0 sec	60426.37	1	1	4.5	0	1.00e+00	Retreg2
Patch foraging water rate 12 sec	70639.93	1	1	4.5	0	1.00e+00	Retreg2
Patch foraging water rate 18 sec	33728.57	1	1	4.5	0	1.00e+00	Retreg2
Patch foraging water rate 24 sec	523.92	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Patch foraging water rate 6 sec	837.86	1	1	4.5	0	1.00e+00	Retreg2
Locomotor activity	26.79	1	1	4.5	0	1.00e+00	Mst1
Locomotor testing distance	13845.45	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Locomotor testing rearing	10576.42	4	2	9.1	0.93	8.05e-03	Kcnj2 LOC134480721 Mst1 Retreg2
Light reinforcement 1	66311.75	1	1	4.5	0	1.00e+00	Retreg2
Light reinforcement 2	18398.05	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Reaction time number correct	63471.78	1	1	4.5	0	1.00e+00	Retreg2
Reaction time mean minus median	119950.29	1	1	4.5	0	1.00e+00	Retreg2
Reaction time mean minus median AUC	62004.19	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Reaction time num false alarms	7685.9	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Reaction time num false alarms AUC	17513.8	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Reaction time trials correct on left	63471.78	1	1	4.5	0	1.00e+00	Retreg2
Reaction time trials on left	60883.54	1	1	4.5	0	1.00e+00	Retreg2
Reaction time mean	14867.01	2	1	4.5	0	1.00e+00	Clec3b Retreg2
Reaction time mean AUC	38768	1	1	4.5	0	1.00e+00	Retreg2
Median of all reaction times	7893.84	1	1	4.5	0	1.00e+00	Retreg2
Reaction time omissions	8364.84	1	1	4.5	0	1.00e+00	Retreg2
Reaction time false alarm rate	111.7	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Reaction time premature initiation rate	9733.76	1	1	4.5	0	1.00e+00	Retreg2
Reaction time premature initiations	53743.58	1	1	4.5	0	1.00e+00	Retreg2
Std. dev. reaction times	20295.68	3	1	4.5	0	1.00e+00	Clec3b Mst1 Retreg2
Reaction time trials completed	60883.54	1	1	4.5	0	1.00e+00	Retreg2
Reaction time trials AUC	62130.65	1	1	4.5	0	1.00e+00	Retreg2
Social response proportion	4397.95	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Social responses	640.25	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Social time	11650.06	1	1	4.5	0	1.00e+00	Retreg2
Conditioned locomotion	1400.08	1	1	4.5	0	1.00e+00	Retreg2
Cocaine response after cond. corrected	19128.47	1	1	4.5	0	1.00e+00	Retreg2
Cocaine response after cond. not corrected	18571.31	1	1	4.5	0	1.00e+00	Retreg2
Cocaine response before conditioning	655.41	1	1	4.5	0	1.00e+00	Retreg2
Saline control response	1639.18	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. active minus inactive responses	7271.32	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. active-inactive response ratio	28713.86	1	1	4.5	0	1.00e+00	Retreg2
Condit. Reinf. active responses	1165.18	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. inactive responses	3650.1	3	2	9.1	0	1.00e+00	Clec3b Mst1 Retreg2
Condit. Reinf. lever presses	1963.38	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. lever reinforcers received	243.91	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever latency	1278.33	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. magazine entry latency	6738.25	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. change in total contacts	39811.91	1	1	4.5	0	1.00e+00	Retreg2
Pavlov. Cond. index score	6407.33	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. latency score	8109.24	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever contacts	2689.72	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. magazine entry number	2097.69	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. intertrial magazine entries	17558.57	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever-magazine prob. diff.	5938.34	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. response bias	641.31	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Conditioned reinforcement - actives	100795.1	1	1	4.5	0	1.00e+00	Retreg2
Conditioned reinforcement - inactives	32505.31	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Conditioned locomotion	5172.85	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Intermittent access intake day 1-15 change	63945.95	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Intermittent access intake escalation	63041.23	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Intermittent access intake escalation 2	36175.43	1	1	4.5	0	1.00e+00	Retreg2
Intermitt. access day 1 inactive lever presses	36139.26	3	2	9.1	-0.94	1.90e-02	Mst1 Retreg2 Sox9
Intermitt. access day 15 inactive lever presses	123608.2	1	1	4.5	0	1.00e+00	Retreg2
Intermitt. access escalation Index	46701.01	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Intermittent access day 1 total infusions	33063.01	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Intermittent access day 15 total infusions	48731.91	1	1	4.5	0	1.00e+00	Retreg2
Intermittent access terminal intake (last 3 days)	24800.59	1	1	4.5	0	1.00e+00	Retreg2
Intermittent access total infusions	181.04	1	1	4.5	0	1.00e+00	Retreg2
Intermittent access day 1 locomotion	34964.22	1	1	4.5	0	1.00e+00	Retreg2
Intermittent access day 15 total locomotion	85548.8	1	1	4.5	0	1.00e+00	Retreg2
Intermittent access total locomotion	116.36	1	1	4.5	0	1.00e+00	Retreg2
Intermittent access standard deviation	56995.61	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Cocaine induced anxiety	69097.7	1	1	4.5	0	1.00e+00	Retreg2
Post-drug Anxiety	4753.56	1	1	4.5	0	1.00e+00	Retreg2
Baseline Anxiety	33506.24	1	1	4.5	0	1.00e+00	Retreg2
Lifetime Intake	1655.49	1	1	4.5	0	1.00e+00	Retreg2
Incentive Sensitization - Responses	71347.91	1	1	4.5	0	1.00e+00	Retreg2
Incentive Sensitization - Breakpoint	55273.76	1	1	4.5	0	1.00e+00	Retreg2
Progressive ratio test 1 active lever presses	31979.35	1	1	4.5	0	1.00e+00	Retreg2
Progressive ratio test 1 breakpoint	30292.17	1	1	4.5	0	1.00e+00	Retreg2
Progressive ratio test 1 inactive lever presses	31120.43	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Progressive ratio test 2 active lever presses	15263.76	1	1	4.5	0	1.00e+00	Retreg2
Progressive ratio test 2 breakpoint	8542.35	1	1	4.5	0	1.00e+00	Retreg2
Progressive ratio test 2 inactive lever presses	72504.33	1	1	4.5	0	1.00e+00	Retreg2
Total sessions with >9 infusions	1005.82	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Short access day 1 total inactive lever presses	19749.92	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Short access day 10 total inactive lever presses	69453.48	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Short access day 1 total infusions	19198	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Short access day 10 total infusions	11366.61	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Short access total infusions	8778.92	1	1	4.5	0	1.00e+00	Retreg2
Short access day 1 locomotion	24803.24	1	1	4.5	0	1.00e+00	Retreg2
Short access day 10 total locomotion	44094.34	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Short access total locomotion	9355.68	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Compulsive drug intake	9345.9	2	1	4.5	0	1.00e+00	Mst1 Retreg2
One hour access (0.3 mA shock)	2329.1	1	1	4.5	0	1.00e+00	Retreg2
One hour access (shock baseline)	54988.81	1	1	4.5	0	1.00e+00	Retreg2
Number of responses in last shaping day	13618.48	1	1	4.5	0	1.00e+00	Retreg2
Context. condit. distance diff. score	212.47	1	1	4.5	0	1.00e+00	Retreg2
Locomotion velocity, session 1	3523.61	1	1	4.5	0	1.00e+00	Retreg2
Locomotion distance, session 1	519.22	2	1	4.5	0	1.00e+00	Clec3b Retreg2
Locomotion velocity, session 2	1110.36	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Locomotion distance, session 2	262.21	2	1	4.5	0	1.00e+00	Clec3b Retreg2
Locomotion velocity, session 3	507.49	1	1	4.5	0	1.00e+00	Retreg2
Locomotion distance, session 3	4009.46	1	1	4.5	0	1.00e+00	Retreg2
Stereotopy head waving bouts, day 3	691.91	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Stereotopy head waving duration, day 3	1446.08	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Locomotion velocity, session 7	210.64	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Locomotion distance, session 7	507.07	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Stereotopy head waving bouts, day 7	1265.52	2	1	4.5	0	1.00e+00	Clec3b Retreg2
Stereotopy head waving duration, day 7	1068.64	2	1	4.5	0	1.00e+00	Clec3b Retreg2
Locomotion velocity, session 8	409.23	1	1	4.5	0	1.00e+00	Retreg2
Locomotion distance, session 8	147.88	1	1	4.5	0	1.00e+00	Retreg2
Degree of sensitization distance	1889.61	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Degree of sensitization stereotypy	690.82	3	1	4.5	0	1.00e+00	Clec3b Mst1 Retreg2
Condit. Reinf. active minus inactive responses	957.65	1	1	4.5	0	1.00e+00	Retreg2
Condit. Reinf. active-inactive response ratio	242.03	1	1	4.5	0	1.00e+00	Retreg2
Condit. Reinf. active responses	2765.7	1	1	4.5	0	1.00e+00	Retreg2
Condit. Reinf. inactive responses	1569.03	3	1	4.5	0	1.00e+00	Clec3b Mst1 Retreg2
Incentive salience index mean	1780.77	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. lever presses	1782.4	3	2	9.1	0	1.00e+00	Clec3b Mst1 Retreg2
Time in familiar zone, hab. session 1	5593.23	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Time in novel zone, hab. session 1	4629.95	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Total zone transitions, hab. session 1	429.72	1	1	4.5	0	1.00e+00	Retreg2
Total locomotion distance, hab. session 1	394.1	1	1	4.5	0	1.00e+00	Retreg2
Locomotion velocity, hab. session 1	266.96	1	1	4.5	0	1.00e+00	Retreg2
Time in familiar zone, hab. session 2	2966.16	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Time in novel zone, hab. session 2	3208.33	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Total zone transitions, hab. session 2	38.53	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Total locomotion distance, hab. session 2	22.17	1	1	4.5	0	1.00e+00	Retreg2
Locomotion velocity, hab. session 2	24.52	2	1	4.5	0	1.00e+00	Clec3b Retreg2
Novel to familiar place preference ratio	7678.6	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Novelty place preference	7474.7	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Time in novel zone, NPP test	3571.61	3	1	4.5	0	1.00e+00	Clec3b Mst1 Retreg2
Total zone transitions, NPP test	973.86	2	1	4.5	0	1.00e+00	Clec3b Retreg2
Total locomotion distance, NPP test	1687.31	1	1	4.5	0	1.00e+00	Retreg2
Locomotion velocity, NPP test	953.07	1	1	4.5	0	1.00e+00	Retreg2
Pavlov. Cond. lever latency	190.65	3	2	9.1	0	1.00e+00	Clec3b Mst1 Retreg2
Pavlov. Cond. change in total contacts	531.56	2	1	4.5	0	1.00e+00	Clec3b Retreg2
Pavlov. Cond. index score	150.43	3	3	13.6	0	1.00e+00	Clec3b Mst1 Retreg2
Pavlov. Cond. latency score	155.8	3	2	9.1	0	1.00e+00	Clec3b Mst1 Retreg2
Pavlov. Cond. lever contacts	260.8	3	3	13.6	0	1.00e+00	Clec3b Mst1 Retreg2
Pavlov. Cond. magazine entry number	250.94	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. intertrial magazine entries	82.71	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever-magazine prob. diff.	158.53	3	3	13.6	0	1.00e+00	Clec3b Mst1 Retreg2
Pavlov. Cond. response bias	211.09	3	3	13.6	0	1.00e+00	Clec3b Mst1 Retreg2
Bone: apparent density	5461.77	1	1	4.5	0	1.00e+00	Retreg2
Bone surface	630.96	8	3	13.6	-0.8	5.94e-03	Abca5 Kcnj16 Kcnj2 LOC134480721 LOC134480722 Map2k6 Mst1 Retreg2
Bone volume	1086.07	6	1	4.5	-0.91	1.52e-03	Abca5 Kcnj16 Kcnj2 LOC134480721 Mst1 Retreg2
Bone: connectivity density	838.02	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Bone: cortical apparent density	3015.15	3	1	4.5	0.94	6.33e-02	Ccdc47 Clec3b Retreg2
Bone: cortical area	63	11	2	9.1	-0.04	7.05e-01	Clec3b Esf1 Fn3k Hexd Ism1 Mst1 Ndufaf5 Rab40b Retreg2 Slc16a3 Tasp1
Bone: cortical porosity	224.42	2	1	4.5	0	1.00e+00	Clec3b Retreg2
Bone: cortical porosity	1113.18	1	1	4.5	0	1.00e+00	Retreg2
Bone: cortical thickness	1488.54	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Bone: cortical tissue density	3259.79	3	1	4.5	0.94	6.50e-02	Ccdc47 Clec3b Retreg2
Bone: elastic displacement	3819.66	2	2	9.1	0	1.00e+00	Clec3b Retreg2
Bone: elastic work	49.61	8	3	13.6	0.97	2.84e-06	Clec3b LOC102549521 LOC102549836 Mst1 Rab40b Retreg2 Slc16a3 Sox9
Bone: endosteal estimation	284.25	17	11	50	-0.76	3.37e-07	Abca5 C1qtnf1 Ccdc47 Cep95 Cyth1 Kcnj16 Kcnj2 LOC102549521 LOC102549596 LOC102549836 LOC134480721 LOC134480722 LOC134480909 Map2k6 Retreg2 Timp2 Usp36
Bone: endosteal perimeter	373.35	19	11	50	-0.7	5.42e-06	Abca5 C1qtnf1 Ccdc47 Cep95 Cyth1 Kcnj16 Kcnj2 LOC102549521 LOC102549596 LOC102549836 LOC134480721 LOC134480722 LOC134480909 Map2k6 Mst1 Retreg2 Sox9 Timp2 Usp36
Bone: final force	343.23	5	2	9.1	-0.89	4.19e-02	Clec3b Mst1 Rab40b Retreg2 Slc16a3
Bone: final moment	67.42	5	2	9.1	-0.83	7.85e-02	Clec3b Mst1 Rab40b Retreg2 Slc16a3
Bone: marrow area	299.59	18	11	50	-0.71	3.36e-06	Abca5 C1qtnf1 Ccdc47 Cep95 Cyth1 Kcnj16 Kcnj2 LOC102549521 LOC102549596 LOC102549836 LOC134480721 LOC134480722 LOC134480909 Map2k6 Mst1 Retreg2 Timp2 Usp36
Bone: maximum diameter	690.17	6	2	9.1	-0.8	8.92e-03	Kcnj16 Kcnj2 LOC134480721 LOC134480722 Mst1 Retreg2
Bone: maximum force	2201.77	4	2	9.1	-0.92	8.38e-02	Mst1 Rab40b Retreg2 Slc16a3
Bone: maximum moment	1524.65	4	3	13.6	-0.91	8.60e-02	Mst1 Rab40b Retreg2 Slc16a3
Bone: minimum diameter	352.13	9	2	9.1	-0.79	2.23e-03	Abca5 Ccdc47 Kcnj16 Kcnj2 LOC134480721 LOC134480722 Map2k6 Mst1 Retreg2
Bone: periosteal estimation	765.55	9	3	13.6	-0.77	2.25e-03	Abca5 Ccdc47 Kcnj16 Kcnj2 LOC134480721 LOC134480722 Map2k6 Mst1 Retreg2
Bone: periosteal perimeter	1913.83	6	2	9.1	-0.81	5.19e-02	Kcnj16 Kcnj2 LOC134480722 Mst1 Rab40b Retreg2
Bone: post-yield work	4567.25	3	1	4.5	0	1.00e+00	Clec3b Mst1 Retreg2
Bone: stiffness	4554.23	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Bone: tissue strength	2995.95	1	1	4.5	0	1.00e+00	Retreg2
Bone: trabecular number	10739.78	1	1	4.5	0	1.00e+00	Retreg2
Bone: trabecular spacing	3991.76	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Bone: trabecular thickness	4257.4	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Bone: trabecular tissue density	7288.79	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Breakpoint value in progressive ratio session	12547.56	3	2	9.1	0	1.00e+00	Clec3b Mst1 Retreg2
Distance traveled before self-admin	50534.09	1	1	4.5	0	1.00e+00	Retreg2
Distance traveled after self-admin	32464.08	1	1	4.5	0	1.00e+00	Retreg2
Delta time in closed arm before/after self-admin	244.69	1	1	4.5	0	1.00e+00	Retreg2
Delta time in open arm before/after self-admin	15131.21	1	1	4.5	0	1.00e+00	Retreg2
Diff in mean of infusions in LGA sessions	18336.8	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Extinction: sum of active levers before priming	9485.06	3	2	9.1	0	1.00e+00	Clec3b Mst1 Retreg2
Active lever presses in extinction session 6	384.74	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Delta distance traveled before/after self-admin	2940.47	1	1	4.5	0	1.00e+00	Retreg2
Delta ambulatory time before/after self-admin	30849.75	1	1	4.5	0	1.00e+00	Retreg2
Time in closed arm before self-admin	13457.43	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Time in closed arm after self-admin	2326.29	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Time in open arm before self-admin	4379.48	2	1	4.5	0	1.00e+00	Mst1 Retreg2
Time in open arm after self-admin	277.78	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Sum of active levers in priming session hrs 5-6	978.69	1	1	4.5	0	1.00e+00	Retreg2
Time to tail flick, vehicle, before self-admin	6696.83	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Time to tail flick, vehicle, after self-admin	42142.71	1	1	4.5	0	1.00e+00	Retreg2
Time to tail flick, test, before self-admin	8139.55	1	1	4.5	0	1.00e+00	Retreg2
Time to tail flick, test, after self-admin	1399.18	1	1	4.5	0	1.00e+00	Retreg2
Delta time to tail flick, vehicle, before/after SA	4924	2	2	9.1	0	1.00e+00	Mst1 Retreg2
Delta time to tail flick, test, before/after SA	15684.59	1	1	4.5	0	1.00e+00	Retreg2
Ambulatory time before self-admin	78874.38	1	1	4.5	0	1.00e+00	Retreg2
Ambulatory time after self-admin	26614.91	1	1	4.5	0	1.00e+00	Retreg2
Total heroin consumption	240.55	1	1	4.5	0	1.00e+00	Retreg2
Area under the delay curve	24791.27	1	1	4.5	0	1.00e+00	Retreg2
Delay disc. indifference point, 0s delay	2159.25	1	1	4.5	0	1.00e+00	Retreg2
Delay disc. indifference point, 16s delay	21959.9	1	1	4.5	0	1.00e+00	Retreg2
Delay disc. indifference point, 2s delay	155.27	1	1	4.5	0	1.00e+00	Retreg2
Delay disc. indifference point, 24s delay	16224.57	2	1	4.5	0	1.00e+00	Clec3b Retreg2
Delay disc. indifference point, 4s delay	616.19	1	1	4.5	0	1.00e+00	Retreg2
Delay disc. indifference point, 8s delay	33362.4	1	1	4.5	0	1.00e+00	Retreg2
Delay discount exponential model param	16922.54	1	1	4.5	0	1.00e+00	Retreg2
Delay discount hyperbolic model param	12277.65	1	1	4.5	0	1.00e+00	Retreg2
Fecal boli incidents, locomotor time 1	61202.36	1	1	4.5	0	1.00e+00	Retreg2
Change in fecal boli incidents, locomotor task	5669.94	1	1	4.5	0	1.00e+00	Retreg2
Time >=10cm from walls, locomotor time 1	13009.3	1	1	4.5	0	1.00e+00	Retreg2
Bouts of movement, locomotor time 1	10785.17	1	1	4.5	0	1.00e+00	Retreg2
Total resting periods, locomotor time 1	2793.59	1	1	4.5	0	1.00e+00	Retreg2
Rest time, locomotor task time 1	22349.64	1	1	4.5	0	1.00e+00	Retreg2
Distance moved, locomotor task time 1	68821.85	1	1	4.5	0	1.00e+00	Retreg2
Vertical activity count, locomotor time 1	142354.07	1	1	4.5	0	1.00e+00	Retreg2
Time >=10cm from walls, locomotor time 2	71159.6	1	1	4.5	0	1.00e+00	Retreg2
Bouts of movement, locomotor time 2	82029.05	1	1	4.5	0	1.00e+00	Retreg2
Total resting periods, locomotor time 2	99042.67	1	1	4.5	0	1.00e+00	Retreg2
Rest time, locomotor task time 2	25503.09	1	1	4.5	0	1.00e+00	Retreg2
Distance moved, locomotor task time 2	8477.87	1	1	4.5	0	1.00e+00	Retreg2
Vertical activity count, locomotor time 2	53555.35	1	1	4.5	0	1.00e+00	Retreg2
Weight adjusted by age	70782.25	1	1	4.5	0	1.00e+00	Retreg2
Seeking ratio, delayed vs. immediate footshock	13445.31	1	1	4.5	0	1.00e+00	Retreg2
Locomotion in novel chamber	3903.37	1	1	4.5	0	1.00e+00	Retreg2
Locomotion in novel chamber post-restriction	65422.89	1	1	4.5	0	1.00e+00	Retreg2
Progressive ratio	67888.93	1	1	4.5	0	1.00e+00	Retreg2
Food seeking constrained by brief footshock	1875.34	1	1	4.5	0	1.00e+00	Retreg2
Seeking ratio, punishment vs. effort	41283.25	1	1	4.5	0	1.00e+00	Retreg2
Run reversals in cocaine runway, females	9406.04	1	1	4.5	0	1.00e+00	Retreg2
Run reversals in cocaine runway, males	7664.74	1	1	4.5	0	1.00e+00	Retreg2
Latency to leave start box in cocaine runway	16290.75	1	1	4.5	0	1.00e+00	Retreg2
Latency to leave start box in cocaine runway, F	7166.92	1	1	4.5	0	1.00e+00	Retreg2
Latency to leave start box in cocaine runway, M	1716.51	1	1	4.5	0	1.00e+00	Retreg2
Co content in liver	1133.25	1	1	4.5	0	1.00e+00	Retreg2
Cu content in liver	39.92	1	1	4.5	0	1.00e+00	Retreg2
Fe content in liver	1344.53	1	1	4.5	0	1.00e+00	Retreg2
K content in liver	1519.62	1	1	4.5	0	1.00e+00	Retreg2
Mg content in liver	6026.97	1	1	4.5	0	1.00e+00	Retreg2
Mn content in liver	1009.39	1	1	4.5	0	1.00e+00	Retreg2
Na content in liver	4018.36	1	1	4.5	0	1.00e+00	Retreg2
Rb content in liver	87.87	1	1	4.5	0	1.00e+00	Retreg2
Zn content in liver	3745.55	1	1	4.5	0	1.00e+00	Retreg2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.6
Adipose	alternative TSS	0	0	1.78
Adipose	gene expression	2	0	1.61
Adipose	isoform ratio	1	0	1.65
Adipose	intron excision ratio	3	0.1	1.69
Adipose	mRNA stability	2	0	1.68
BLA	alternative polyA	0	0	1.66
BLA	alternative TSS	2	0.1	1.61
BLA	gene expression	2	0	1.67
BLA	isoform ratio	4	0.1	1.69
BLA	intron excision ratio	2	0.1	1.71
BLA	mRNA stability	0	0	1.63
Brain	alternative polyA	0	0	1.63
Brain	alternative TSS	4	0.1	1.73
Brain	gene expression	7	0.1	1.67
Brain	isoform ratio	7	0.1	1.73
Brain	intron excision ratio	5	0.1	1.76
Brain	mRNA stability	3	0.1	1.68
Eye	alternative polyA	0	0	2.08
Eye	alternative TSS	0	0	1.72
Eye	gene expression	1	0.1	1.77
Eye	isoform ratio	0	0	1.73
Eye	intron excision ratio	1	0.1	1.58
Eye	mRNA stability	0	0	1.6
IC	alternative polyA	0	0	1.74
IC	alternative TSS	1	0.1	1.76
IC	gene expression	4	0.1	1.69
IC	isoform ratio	2	0.1	1.79
IC	intron excision ratio	4	0.1	1.68
IC	mRNA stability	0	0	1.55
IL	alternative polyA	0	0	1.66
IL	alternative TSS	0	0	1.62
IL	gene expression	4	0.1	1.69
IL	isoform ratio	0	0	1.73
IL	intron excision ratio	0	0	1.66
IL	mRNA stability	0	0	1.68
LHb	alternative polyA	0	0	1.66
LHb	alternative TSS	0	0	1.71
LHb	gene expression	7	0.2	1.76
LHb	isoform ratio	0	0	1.59
LHb	intron excision ratio	0	0	1.5
LHb	mRNA stability	0	0	1.73
Liver	alternative polyA	0	0	1.71
Liver	alternative TSS	0	0	1.69
Liver	gene expression	3	0	1.64
Liver	isoform ratio	2	0.1	1.79
Liver	intron excision ratio	1	0	1.54
Liver	mRNA stability	0	0	1.66
NAcc	alternative polyA	2	0.1	1.77
NAcc	alternative TSS	2	0.1	1.62
NAcc	gene expression	4	0	1.67
NAcc	isoform ratio	4	0.1	1.68
NAcc	intron excision ratio	5	0.1	1.71
NAcc	mRNA stability	0	0	1.64
OFC	alternative polyA	0	0	1.71
OFC	alternative TSS	0	0	1.74
OFC	gene expression	3	0.1	1.72
OFC	isoform ratio	0	0	1.7
OFC	intron excision ratio	2	0.2	1.71
OFC	mRNA stability	0	0	1.63
PL	alternative polyA	0	0	1.65
PL	alternative TSS	2	0.1	1.69
PL	gene expression	4	0	1.69
PL	isoform ratio	9	0.2	1.71
PL	intron excision ratio	5	0.1	1.68
PL	mRNA stability	0	0	1.63
pVTA	alternative polyA	3	0.1	1.62
pVTA	alternative TSS	2	0.1	1.68
pVTA	gene expression	4	0.1	1.72
pVTA	isoform ratio	6	0.2	1.73
pVTA	intron excision ratio	6	0.1	1.66
pVTA	mRNA stability	0	0	1.63
RMTg	alternative polyA	0	0	1.46
RMTg	alternative TSS	0	0	1.63
RMTg	gene expression	0	0	1.73
RMTg	isoform ratio	4	0.5	1.74
RMTg	intron excision ratio	1	0.1	1.75
RMTg	mRNA stability	0	0	1.66