Best TWAS P=1.500228e-13 · Best GWAS P=1.871987e-07 conditioned to 6.078233e-24
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | NA | gene expression | ENSRNOG00000062661 | 0.04 | 0.04 | top1 | 1 | 0.04 | 1.9e-05 | 5.2 | 5.2 | 2.5e-07 | 0.85 | 0.05 | 0.91 | FALSE |
| 2 | BLA | NA | gene expression | ENSRNOG00000068691 | 0.13 | 0.00 | blup | 840 | 0.02 | 1.9e-02 | -3.5 | 5.3 | 1.0e-07 | 0.87 | 0.12 | 0.72 | FALSE |
| 3 | BLA | Mcrip1 | intron excision ratio | chr10:105822705:105828028 | 0.06 | 0.03 | enet | 15 | 0.03 | 6.8e-03 | -4.9 | -5.2 | 2.3e-07 | -0.62 | 0.38 | 0.53 | FALSE |
| 4 | LHb | NA | gene expression | ENSRNOG00000068691 | 0.40 | 0.03 | blup | 840 | 0.05 | 2.3e-02 | 5.0 | 5.1 | 3.1e-07 | 0.91 | 0.11 | 0.44 | FALSE |
| 5 | NAcc | Ccdc57 | alternative TSS | ENSRNOT00000095877 | 0.27 | 0.02 | blup | 1793 | 0.02 | 5.9e-03 | -4.7 | 7.4 | 1.5e-13 | 0.49 | 0.22 | 0.36 | TRUE |
| 6 | NAcc | Ccdc57 | alternative TSS | ENSRNOT00000098223 | 0.24 | 0.02 | blup | 1793 | 0.02 | 7.7e-03 | -4.7 | -7.4 | 1.7e-13 | -0.51 | 0.21 | 0.36 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.