Hub : Genes

Tdrd1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000017064 0.08 0.05 1.8e-06 0.04 0.05 0.05 0.05 1.2e-05 7.0e-06 6.6e-06 7.8e-06
2 BLA gene expression ENSRNOG00000017064 0.12 0.09 1.2e-03 0.05 0.04 0.04 0.04 9.1e-04 3.6e-03 4.6e-03 2.5e-03
3 NAcc gene expression ENSRNOG00000017064 0.06 0.05 1.9e-03 0.04 0.03 0 0.02 1.0e-03 5.8e-03 1.6e-01 8.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail3.210.221.6-4.62.41.9
BMI without tail1.43.05.1-2.31.51.2
Body weight3.213.628.5-5.32.52.4
Epididymis fat weight5.212.121.1-4.62.82.7
Glucose1.93.06.0-2.41.21.3
Heart weight1.11.64.3-2.10.40.6
Left kidney weight2.98.310.2-3.2-2.7-2.7
Right kidney weight3.18.821.5-4.6-1.6-1.6
Tail length0.10.40.8-0.20.60.9
Length with tail0.72.45.9-2.40.61.0
Length without tail1.84.010.8-3.30.80.9
Liver weight, left1.93.03.4-1.81.71.7
Liver weight, right2.43.98.1-2.81.41.2
Parametrial fat weight5.09.911.5-2.83.23.4
Retroperitoneal fat weight4.615.228.3-5.32.93.0
Intraocular pressure2.73.84.6-2.21.91.8
Extensor digitorum longus weight0.51.92.8-0.41.61.7
Soleus weight1.23.610.9-3.3-0.10.1
Tibialis anterior weight0.30.91.5-0.21.21.1
Tibia length0.82.16.2-2.5-0.4-0.3
Number of licking bursts0.70.91.40.21.21.1
Food consumed during 24 hour testing period0.20.20.40.6-0.2-0.4
Times rat made contact with spout0.40.50.6-0.7-0.5-0.8
Mean time between licks in bursts0.50.61.20.50.71.1
Mean num. licks in bursts1.82.22.8-1.0-1.6-1.7
Std. dev. time between licks in bursts0.10.20.40.60.20.2
Water consumed over 24 hours0.60.71.1-0.6-0.9-1.1
Indifference point 0 sec2.33.84.4-2.11.72.0
Indifference point AUC0.80.91.6-0.51.01.3
Indifference point function ln k0.10.10.2-0.2-0.3-0.4
Indifference point function log k0.10.10.2-0.2-0.3-0.4
Delay discounting total patch changes 0 sec2.64.24.9-2.01.92.2
Delay discounting total patch changes 12 sec1.82.44.2-0.41.72.0
Delay discounting total patch changes 18 sec2.83.74.8-1.42.02.2
Delay discounting total patch changes 24 sec2.83.55.2-0.92.22.3
Delay discounting total patch changes 6 sec3.24.95.2-2.22.12.3
Delay discounting time to switch 0 sec0.50.80.90.9-0.8-0.9
Delay discounting water rate 0 sec0.60.91.2-1.10.90.8
Delay discounting water rate 12 sec2.43.65.7-0.82.42.1
Delay discounting water rate 18 sec0.40.51.5-1.2-0.1-0.2
Delay discounting water rate 24 sec0.40.61.7-1.3-0.2-0.3
Delay discounting water rate 6 sec0.30.51.0-1.0-0.3-0.6
Locomotor activity0.60.92.8-1.7-0.00.0
Locomotor testing distance1.32.15.0-2.2-0.8-0.8
Locomotor testing rearing0.30.51.3-1.2-0.3-0.4
Light reinforcement 10.91.63.21.8-0.9-0.9
Light reinforcement 21.72.22.91.7-1.3-1.5
Reaction time number correct0.71.01.7-0.61.31.0
Reaction time mean minus median0.50.71.8-1.3-0.5-0.3
Reaction time mean minus median AUC1.01.31.8-1.3-1.1-1.0
Reaction time num false alarms0.00.00.00.0-0.1-0.2
Reaction time num false alarms AUC0.10.20.3-0.2-0.5-0.6
Reaction time trials correct on left0.71.01.7-0.61.31.0
Reaction time trials on left0.71.11.7-0.71.31.0
Reaction time mean0.40.61.5-1.2-0.4-0.3
Reaction time mean AUC0.20.30.6-0.8-0.4-0.3
Median of all reaction times0.40.61.3-1.1-0.6-0.4
Reaction time omissions0.10.10.3-0.50.30.2
Reaction time false alarm rate0.30.40.50.3-0.7-0.7
Reaction time premature initiation rate1.31.72.0-1.2-1.4-1.3
Reaction time premature initiations1.01.42.9-1.7-0.8-0.8
Std. dev. reaction times1.11.54.4-2.1-0.2-0.0
Reaction time trials completed0.71.11.7-0.71.31.0
Reaction time trials AUC0.81.11.7-0.71.31.1
Social response proportion2.52.74.3-2.1-1.4-1.4
Social responses1.92.56.3-2.50.70.8
Social time1.01.33.3-1.8-0.6-0.4
Conditioned locomotion0.20.20.40.1-0.6-0.4
Cocaine response after cond. corrected3.43.85.70.4-2.3-2.4
Cocaine response after cond. not corrected2.22.53.50.8-1.8-1.9
Cocaine response before conditioning1.82.12.81.11.71.6
Saline control response0.40.50.7-0.7-0.8-0.6
Condit. Reinf. active minus inactive responses3.03.75.2-1.02.22.3
Condit. Reinf. active-inactive response ratio1.11.21.8-0.31.31.4
Condit. Reinf. active responses4.46.18.4-1.62.82.9
Condit. Reinf. inactive responses2.02.53.4-1.01.71.8
Condit. Reinf. lever presses1.01.42.4-0.31.31.6
Condit. Reinf. lever reinforcers received3.24.56.3-1.32.42.5
Pavlov. Cond. lever latency0.91.31.90.1-1.4-1.4
Pavlov. Cond. magazine entry latency0.60.61.0-0.21.01.0
Pavlov. Cond. change in total contacts1.21.72.5-0.71.51.6
Pavlov. Cond. index score0.91.21.6-0.71.21.3
Pavlov. Cond. latency score0.91.11.6-0.61.21.3
Pavlov. Cond. lever contacts0.40.50.7-0.40.90.9
Pavlov. Cond. magazine entry number0.40.50.80.2-0.9-0.9
Pavlov. Cond. intertrial magazine entries0.10.10.20.10.40.5
Pavlov. Cond. lever-magazine prob. diff.0.70.91.1-0.81.01.1
Pavlov. Cond. response bias0.71.01.4-0.51.21.2
Conditioned reinforcement - actives2.42.43.9-0.6-2.0-1.7
Conditioned reinforcement - inactives0.20.20.7-0.8-0.20.1
Conditioned locomotion2.02.43.8-0.4-2.0-1.8
Intermittent access intake day 1-15 change1.11.12.0-1.40.80.8
Intermittent access intake escalation1.51.44.2-2.0-0.3-0.2
Intermittent access intake escalation 21.01.01.9-1.4-0.8-0.6
Intermitt. access day 1 inactive lever presses1.61.82.6-0.61.61.5
Intermitt. access day 15 inactive lever presses0.00.00.1-0.40.00.1
Intermitt. access escalation Index0.20.20.40.3-0.6-0.1
Intermittent access day 1 total infusions0.20.20.4-0.3-0.6-0.5
Intermittent access day 15 total infusions0.50.61.3-1.2-0.6-0.4
Intermittent access terminal intake (last 3 days)0.40.40.6-0.8-0.7-0.4
Intermittent access total infusions0.80.81.8-1.3-0.7-0.5
Intermittent access day 1 locomotion1.21.31.9-0.3-1.4-1.4
Intermittent access day 15 total locomotion1.11.23.0-1.70.50.6
Intermittent access total locomotion1.61.81.9-1.4-1.4-1.3
Intermittent access standard deviation0.80.91.3-0.21.11.1
Cocaine induced anxiety3.43.95.22.3-1.7-1.8
Post-drug Anxiety1.11.21.61.0-1.0-1.3
Baseline Anxiety3.63.84.8-2.21.91.7
Lifetime Intake1.01.12.1-1.4-0.9-0.7
Incentive Sensitization - Responses0.70.72.0-1.40.20.2
Incentive Sensitization - Breakpoint0.80.82.0-1.40.40.3
Progressive ratio test 1 active lever presses1.61.71.9-1.4-1.3-1.2
Progressive ratio test 1 breakpoint0.80.90.9-0.9-1.0-0.9
Progressive ratio test 1 inactive lever presses0.10.10.2-0.1-0.4-0.3
Progressive ratio test 2 active lever presses1.71.84.0-2.0-0.9-0.8
Progressive ratio test 2 breakpoint1.31.53.6-1.9-0.7-0.6
Progressive ratio test 2 inactive lever presses0.40.40.7-0.80.40.7
Total sessions with >9 infusions4.34.710.8-3.3-1.3-1.3
Short access day 1 total inactive lever presses0.00.00.00.0-0.2-0.1
Short access day 10 total inactive lever presses0.50.60.7-0.70.70.8
Short access day 1 total infusions1.31.41.6-1.1-1.3-1.2
Short access day 10 total infusions1.11.21.7-0.8-1.3-1.1
Short access total infusions1.41.61.8-1.2-1.4-1.2
Short access day 1 locomotion0.90.91.2-1.1-0.9-0.8
Short access day 10 total locomotion0.50.50.8-0.9-0.5-0.7
Short access total locomotion3.03.13.7-1.5-1.8-1.9
Compulsive drug intake0.70.70.80.90.80.7
One hour access (0.3 mA shock)0.60.71.2-0.70.71.1
One hour access (shock baseline)0.91.02.8-1.7-0.4-0.1
Number of responses in last shaping day0.40.40.7-0.5-0.8-0.5
Context. condit. distance diff. score0.91.12.21.5-0.8-0.7
Locomotion velocity, session 10.10.10.1-0.1-0.3-0.3
Locomotion distance, session 11.62.02.9-1.1-1.4-1.7
Locomotion velocity, session 22.12.53.9-0.8-1.7-2.0
Locomotion distance, session 21.52.23.1-1.8-1.2-1.4
Locomotion velocity, session 31.31.52.1-0.8-1.3-1.5
Locomotion distance, session 32.12.33.4-0.6-1.8-1.8
Stereotopy head waving bouts, day 30.10.10.2-0.50.20.2
Stereotopy head waving duration, day 30.30.40.70.10.70.8
Locomotion velocity, session 70.10.10.1-0.20.40.4
Locomotion distance, session 70.10.20.30.4-0.3-0.5
Stereotopy head waving bouts, day 70.10.10.3-0.00.30.6
Stereotopy head waving duration, day 70.70.91.1-0.90.91.1
Locomotion velocity, session 81.11.32.81.7-0.8-0.8
Locomotion distance, session 81.42.23.10.8-1.6-1.8
Degree of sensitization distance2.02.02.81.71.41.2
Degree of sensitization stereotypy0.20.30.50.10.50.7
Condit. Reinf. active minus inactive responses0.20.20.4-0.2-0.4-0.6
Condit. Reinf. active-inactive response ratio0.00.00.00.0-0.0-0.2
Condit. Reinf. active responses0.50.61.6-1.30.30.1
Condit. Reinf. inactive responses1.11.32.6-1.60.80.8
Incentive salience index mean0.50.61.0-0.4-0.8-1.0
Condit. Reinf. lever presses0.20.30.4-0.6-0.5-0.6
Time in familiar zone, hab. session 10.10.10.2-0.3-0.2-0.5
Time in novel zone, hab. session 10.70.71.10.01.01.0
Total zone transitions, hab. session 10.81.22.6-1.6-0.6-0.8
Total locomotion distance, hab. session 10.10.10.20.4-0.3-0.4
Locomotion velocity, hab. session 10.20.30.30.5-0.5-0.6
Time in familiar zone, hab. session 22.12.23.6-0.21.91.7
Time in novel zone, hab. session 21.71.72.7-0.5-1.6-1.4
Total zone transitions, hab. session 20.81.12.7-1.6-0.2-0.7
Total locomotion distance, hab. session 20.30.40.6-0.5-0.5-0.8
Locomotion velocity, hab. session 20.30.40.7-0.3-0.6-0.8
Novel to familiar place preference ratio0.50.60.80.30.90.9
Novelty place preference0.50.50.90.20.81.0
Time in novel zone, NPP test1.21.22.00.11.31.4
Total zone transitions, NPP test0.30.40.6-0.8-0.3-0.7
Total locomotion distance, NPP test0.10.10.40.0-0.3-0.6
Locomotion velocity, NPP test0.50.71.50.3-0.8-1.2
Pavlov. Cond. lever latency0.50.61.20.30.81.1
Pavlov. Cond. magazine entry latency0.10.10.2-0.2-0.2-0.5
Pavlov. Cond. change in total contacts0.10.10.2-0.1-0.3-0.5
Pavlov. Cond. index score0.10.10.2-0.4-0.2-0.4
Pavlov. Cond. latency score0.10.20.3-0.5-0.3-0.5
Pavlov. Cond. lever contacts0.10.10.1-0.3-0.2-0.4
Pavlov. Cond. magazine entry number0.30.31.01.00.00.3
Pavlov. Cond. intertrial magazine entries0.20.20.6-0.8-0.30.0
Pavlov. Cond. lever-magazine prob. diff.0.00.10.1-0.30.0-0.3
Pavlov. Cond. response bias0.20.30.4-0.6-0.4-0.6
Bone: apparent density2.03.34.7-0.92.22.1
Bone surface0.61.01.3-0.71.21.2
Bone volume1.73.03.3-1.51.81.8
Bone: connectivity density0.50.71.10.31.01.0
Bone: cortical apparent density3.74.87.0-0.9-2.6-2.6
Bone: cortical area4.77.212.4-3.52.12.1
Bone: cortical porosity0.40.40.70.20.80.7
Bone: cortical porosity0.80.91.40.41.21.0
Bone: cortical thickness2.23.68.4-2.91.11.1
Bone: cortical thickness0.70.82.5-1.6-0.0-0.1
Bone: cortical tissue density3.84.97.3-0.7-2.7-2.6
Bone: elastic displacement0.20.30.40.60.50.4
Bone: elastic work0.50.71.7-1.3-0.5-0.5
Bone: endosteal estimation0.61.32.0-1.41.01.0
Bone: endosteal perimeter2.14.310.0-3.21.21.2
Bone: final force1.52.46.7-2.60.50.5
Bone: final moment1.42.36.3-2.50.60.6
Bone: marrow area0.61.42.0-1.41.01.1
Bone: maximum diameter4.58.210.2-3.22.62.7
Bone: maximum force1.32.36.5-2.50.50.5
Bone: maximum moment1.32.25.9-2.40.60.6
Bone: minimum diameter1.83.43.8-1.91.81.8
Bone: periosteal estimation2.55.19.2-3.01.71.8
Bone: periosteal perimeter5.08.217.3-4.21.91.9
Bone: post-yield work0.20.30.30.60.60.6
Bone: stiffness1.01.54.5-2.10.20.1
Bone: tissue strength0.30.20.50.70.30.4
Bone: trabecular number1.52.33.5-0.01.91.8
Bone: trabecular spacing0.10.10.20.50.30.1
Bone: trabecular thickness3.23.94.4-1.92.02.1
Bone: trabecular tissue density0.91.32.3-1.5-0.9-0.9
Breakpoint value in progressive ratio session0.60.70.91.00.90.5
Distance traveled before self-admin0.50.61.20.2-1.1-0.7
Distance traveled after self-admin1.71.93.1-0.5-1.8-1.6
Delta time in closed arm before/after self-admin0.50.51.00.1-1.0-0.8
Delta time in open arm before/after self-admin0.50.50.9-0.10.90.8
Diff in mean of infusions in LGA sessions2.42.67.12.70.80.5
Extinction: sum of active levers before priming0.70.71.91.40.40.1
Active lever presses in extinction session 60.00.00.00.10.1-0.1
Delta distance traveled before/after self-admin0.70.71.0-0.6-0.8-1.0
Delta ambulatory time before/after self-admin0.10.10.1-0.4-0.1-0.2
Time in closed arm before self-admin0.00.00.00.10.00.2
Time in closed arm after self-admin0.60.60.80.6-0.9-0.8
Time in open arm before self-admin0.80.82.41.6-0.1-0.3
Time in open arm after self-admin0.40.50.50.70.70.6
Sum of active levers in priming session hrs 5-60.90.92.61.60.10.0
Time to tail flick, vehicle, before self-admin1.81.81.9-1.31.41.4
Time to tail flick, vehicle, after self-admin0.30.30.9-0.9-0.3-0.1
Time to tail flick, test, before self-admin4.03.94.5-1.7-2.1-2.1
Time to tail flick, test, after self-admin1.01.12.1-1.50.70.7
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.0-0.5-0.3
Delta time to tail flick, test, before/after SA3.02.74.0-0.81.82.0
Ambulatory time before self-admin0.40.40.6-0.3-0.8-0.6
Ambulatory time after self-admin1.41.52.6-0.4-1.6-1.3
Total heroin consumption0.70.91.3-0.21.11.1
Area under the delay curve0.40.40.7-0.20.90.7
Delay disc. indifference point, 0s delay0.10.10.1-0.3-0.2-0.1
Delay disc. indifference point, 16s delay0.40.40.60.50.80.5
Delay disc. indifference point, 2s delay0.20.20.40.7-0.2-0.2
Delay disc. indifference point, 24s delay2.22.13.50.31.91.7
Delay disc. indifference point, 4s delay0.30.30.80.90.40.3
Delay disc. indifference point, 8s delay1.92.04.1-2.01.00.9
Delay discount exponential model param0.40.50.80.2-0.9-0.7
Delay discount hyperbolic model param0.30.30.50.1-0.7-0.5
Fecal boli incidents, locomotor time 11.51.61.8-1.31.21.3
Change in fecal boli incidents, locomotor task1.41.33.61.9-0.2-0.5
Time >=10cm from walls, locomotor time 10.70.72.11.5-0.2-0.2
Bouts of movement, locomotor time 10.80.91.6-0.41.01.3
Total resting periods, locomotor time 10.40.50.8-0.50.70.9
Rest time, locomotor task time 11.01.11.2-1.1-1.0-1.0
Distance moved, locomotor task time 10.40.40.50.70.70.6
Vertical activity count, locomotor time 10.40.41.21.1-0.1-0.3
Time >=10cm from walls, locomotor time 20.70.70.90.60.90.9
Bouts of movement, locomotor time 21.51.63.41.9-1.0-0.6
Total resting periods, locomotor time 21.11.22.21.5-1.0-0.6
Rest time, locomotor task time 20.20.30.3-0.6-0.6-0.4
Distance moved, locomotor task time 20.30.40.6-0.10.70.7
Vertical activity count, locomotor time 20.40.50.9-0.30.90.7
Weight adjusted by age2.93.29.4-3.10.30.3
Seeking ratio, delayed vs. immediate footshock0.50.60.80.6-0.9-0.8
Locomotion in novel chamber1.31.62.5-0.3-1.5-1.6
Locomotion in novel chamber post-restriction2.12.54.0-0.3-1.9-2.0
Progressive ratio0.20.30.70.8-0.0-0.3
Food seeking constrained by brief footshock1.11.32.11.51.10.8
Seeking ratio, punishment vs. effort0.10.10.30.10.20.5
Run reversals in cocaine runway, females0.70.71.7-1.3-0.4-0.4
Run reversals in cocaine runway, males1.41.34.02.00.00.1
Latency to leave start box in cocaine runway0.50.51.11.1-0.3-0.6
Latency to leave start box in cocaine runway, F0.50.61.31.1-0.3-0.6
Latency to leave start box in cocaine runway, M0.10.10.1-0.3-0.2-0.3
Cd content in liver0.91.03.01.7-0.2-0.2
Co content in liver0.30.40.5-0.3-0.7-0.7
Cu content in liver0.30.30.5-0.7-0.5-0.4
Fe content in liver0.10.10.1-0.10.40.2
K content in liver0.20.20.60.8-0.00.1
Mg content in liver0.40.40.60.60.60.7
Mn content in liver0.60.71.61.3-0.6-0.5
Na content in liver0.80.81.11.10.70.9
Rb content in liver1.01.33.51.90.30.4
Se content in liver0.20.20.30.30.50.5
Sr content in liver2.82.63.21.2-1.8-1.8
Zn content in liver1.61.72.01.1-1.4-1.4