Hub : Genes

Ism1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000063262	0.05	0.03	2.4e-04	0	0.02	0.01	0.01	1.0e-01	2.9e-03	1.6e-02	1.1e-02
2	Brain	gene expression	ENSRNOG00000063262	0.05	0.03	7.9e-05	0.03	0.04	0.04	0.03	5.8e-04	1.3e-04	8.7e-05	3.8e-04
3	Eye	gene expression	ENSRNOG00000063262	0.59	0.18	3.8e-04	0.02	0.07	-0.01	0.04	1.5e-01	3.4e-02	4.4e-01	9.0e-02
4	LHb	gene expression	ENSRNOG00000063262	0.48	0.13	6.1e-11	0.45	0.46	0.47	0.47	3.9e-12	2.5e-12	1.4e-12	9.7e-13
5	OFC	gene expression	ENSRNOG00000063262	0.24	0.14	3.1e-04	0.12	0.04	0.06	0.04	1.1e-03	3.4e-02	1.4e-02	3.3e-02
6	PL	gene expression	ENSRNOG00000063262	0.05	0.04	7.7e-04	0.02	0.04	0.03	0.03	1.9e-02	7.1e-04	1.4e-03	3.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
BMI with tail	3.6	11.6	17.7	-1.0	-4.2	4.2	-3.1	-4.2	-2.5
BMI without tail	3.0	6.2	10.5	-0.7	-3.2	3.0	-2.2	-3.1	-1.7
Body weight	5.6	23.6	35.8	-2.3	-6.0	5.9	-5.0	-5.6	-2.9
Epididymis fat weight	5.7	13.2	20.6	-0.9	-4.5	4.4	-3.4	-4.4	-2.8
Glucose	0.8	1.2	1.7	0.1	-1.3	1.3	-0.7	-1.3	-1.2
Heart weight	1.8	2.6	3.8	-0.9	-1.9	1.9	-1.9	-1.8	-0.7
Left kidney weight	0.6	1.6	2.4	-1.1	-1.1	1.6	-1.3	-1.6	-0.8
Right kidney weight	0.6	1.8	2.7	-1.5	-1.2	1.5	-1.6	-1.5	-0.4
Tail length	1.0	3.1	4.5	-1.3	-2.1	2.1	-2.1	-1.9	-0.7
Length with tail	2.1	7.8	11.3	-1.8	-3.4	3.4	-3.2	-3.0	-1.3
Length without tail	1.0	2.3	3.4	-0.6	-1.8	1.9	-1.7	-1.7	-1.0
Liver weight, left	0.6	0.9	1.6	-0.1	-1.3	1.2	-0.7	-1.2	-0.7
Liver weight, right	1.8	3.1	6.1	-2.2	-1.7	1.7	-2.5	-1.2	0.6
Parametrial fat weight	2.1	4.2	7.2	-0.7	-2.7	2.5	-1.9	-2.4	-1.2
Retroperitoneal fat weight	5.7	18.8	29.2	-1.5	-5.3	5.4	-4.2	-5.2	-3.1
Intraocular pressure	0.5	0.6	1.0	-0.9	-0.5	0.8	-1.0	-0.9	-0.4
Extensor digitorum longus weight	0.0	0.1	0.4	0.4	-0.2	0.2	0.3	-0.6	-0.4
Soleus weight	0.1	0.3	0.6	-0.4	0.8	-0.5	0.2	0.5	0.6
Tibialis anterior weight	0.3	1.0	1.9	0.6	-1.3	1.0	-0.2	-1.4	-0.9
Tibia length	4.9	13.8	22.4	-1.7	-4.7	4.5	-3.9	-4.2	-2.0
Number of licking bursts	0.4	0.5	1.8	-1.3	-0.1	0.5	-0.9	-0.2	0.1
Food consumed during 24 hour testing period	3.6	4.4	9.1	3.0	-0.9	0.8	1.6	-2.1	-2.9
Times rat made contact with spout	0.4	0.5	1.1	1.1	0.3	-0.3	1.0	-0.1	-0.6
Mean time between licks in bursts	2.2	3.1	7.1	-2.4	-1.5	1.4	-2.7	-0.6	1.0
Mean num. licks in bursts	0.8	0.9	3.3	1.8	-0.2	-0.2	1.2	-0.2	-0.7
Std. dev. time between licks in bursts	0.2	0.2	0.7	-0.8	0.1	0.0	-0.6	0.1	0.3
Water consumed over 24 hours	0.9	1.0	2.3	1.5	0.1	-0.0	1.2	-0.8	-1.4
Indifference point 0 sec	1.5	2.4	4.1	1.0	2.0	-1.8	2.0	1.2	0.5
Indifference point AUC	5.9	6.9	11.8	-1.2	2.8	-2.9	0.8	3.4	3.3
Indifference point function ln k	4.0	5.6	10.7	1.0	-2.4	2.6	-0.6	-3.3	-3.1
Indifference point function log k	4.0	5.6	10.7	1.0	-2.4	2.6	-0.6	-3.3	-3.1
Delay discounting total patch changes 0 sec	1.8	2.9	4.9	0.9	2.2	-2.1	2.1	1.6	0.9
Delay discounting total patch changes 12 sec	2.2	2.9	4.4	0.4	2.0	-2.1	1.6	2.0	1.6
Delay discounting total patch changes 18 sec	7.5	9.9	15.7	-0.0	3.8	-3.9	2.3	4.0	3.1
Delay discounting total patch changes 24 sec	5.7	7.2	11.3	0.1	3.1	-3.3	1.9	3.4	2.7
Delay discounting total patch changes 6 sec	3.5	5.3	8.3	-0.6	2.8	-2.7	1.2	2.9	2.6
Delay discounting time to switch 0 sec	2.3	3.5	5.3	0.6	-2.3	2.2	-1.0	-2.2	-2.1
Delay discounting water rate 0 sec	2.9	4.7	7.5	-0.7	2.7	-2.6	1.2	2.6	2.3
Delay discounting water rate 12 sec	0.8	1.2	2.1	-0.6	1.5	-1.3	0.5	1.0	1.3
Delay discounting water rate 18 sec	0.8	1.1	2.8	-1.7	0.7	-0.5	-0.7	0.7	1.5
Delay discounting water rate 24 sec	2.3	3.2	6.2	-2.4	1.6	-1.2	-0.7	1.7	2.5
Delay discounting water rate 6 sec	1.1	1.6	5.3	-2.3	-0.3	0.6	-1.8	-0.0	1.0
Locomotor activity	0.8	1.3	2.9	1.7	0.8	-1.0	1.7	0.5	-0.4
Locomotor testing distance	1.5	2.4	4.6	1.9	1.5	-1.6	2.2	1.1	-0.1
Locomotor testing rearing	2.4	3.7	5.8	1.6	2.2	-2.3	2.4	1.8	0.7
Light reinforcement 1	1.0	1.9	4.1	1.9	1.1	-1.2	2.0	0.7	-0.6
Light reinforcement 2	0.3	0.4	1.1	1.1	-0.1	0.0	0.7	-0.2	-0.8
Reaction time number correct	0.6	0.8	1.8	-1.3	0.4	-0.4	-0.8	0.8	1.3
Reaction time mean minus median	0.5	0.7	1.9	0.6	-0.5	0.7	0.1	-1.0	-1.4
Reaction time mean minus median AUC	0.1	0.1	0.5	0.3	0.0	0.1	0.2	-0.3	-0.7
Reaction time num false alarms	0.1	0.1	0.3	0.0	0.3	-0.4	0.2	0.2	0.5
Reaction time num false alarms AUC	0.3	0.5	1.0	-0.2	0.7	-0.8	0.3	0.8	1.0
Reaction time trials correct on left	0.6	0.8	1.8	-1.3	0.4	-0.4	-0.8	0.8	1.3
Reaction time trials on left	0.6	0.9	1.9	-1.3	0.4	-0.4	-0.8	0.9	1.4
Reaction time mean	0.3	0.4	1.3	0.5	-0.3	0.4	0.2	-0.7	-1.1
Reaction time mean AUC	0.3	0.4	1.3	0.5	-0.3	0.5	0.3	-0.8	-1.1
Median of all reaction times	0.2	0.2	0.8	0.5	-0.1	0.2	0.4	-0.4	-0.9
Reaction time omissions	0.2	0.3	0.4	-0.2	0.6	-0.6	0.1	0.6	0.7
Reaction time false alarm rate	0.2	0.2	0.4	0.4	0.5	-0.6	0.6	0.3	0.3
Reaction time premature initiation rate	0.1	0.2	0.5	0.1	-0.2	0.4	-0.3	-0.4	-0.7
Reaction time premature initiations	0.2	0.3	0.6	-0.8	0.3	-0.0	-0.7	0.4	0.4
Std. dev. reaction times	0.4	0.5	1.6	0.3	-0.4	0.6	0.1	-0.9	-1.3
Reaction time trials completed	0.6	0.9	1.9	-1.3	0.4	-0.4	-0.8	0.9	1.4
Reaction time trials AUC	0.6	0.8	1.8	-1.3	0.3	-0.3	-0.8	0.8	1.4
Social response proportion	0.7	0.8	1.9	-0.0	-0.8	0.9	-0.4	-1.4	-1.1
Social responses	0.1	0.1	0.2	-0.2	0.4	-0.3	0.1	0.4	0.2
Social time	0.5	0.6	1.1	1.0	-0.1	0.3	0.7	-0.9	-1.1
Conditioned locomotion	1.4	1.6	2.5	-0.6	-1.6	1.5	-1.2	-1.6	-0.7
Cocaine response after cond. corrected	0.2	0.2	0.4	-0.6	0.4	-0.3	-0.2	0.5	0.5
Cocaine response after cond. not corrected	0.2	0.2	0.3	-0.2	0.5	-0.5	0.3	0.6	0.3
Cocaine response before conditioning	0.6	0.7	1.8	1.3	0.4	-0.5	1.3	0.2	-0.5
Saline control response	0.0	0.0	0.1	0.2	-0.4	0.1	0.0	-0.2	0.0
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	0.2	0.7	-0.6	0.4	0.5	0.3
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	0.1	0.6	-0.6	0.3	0.6	0.4
Condit. Reinf. active responses	0.1	0.2	0.3	0.3	0.6	-0.5	0.5	0.4	0.2
Condit. Reinf. inactive responses	0.1	0.1	0.1	0.2	0.2	-0.3	0.3	0.3	0.2
Condit. Reinf. lever presses	1.8	2.5	5.5	2.1	1.5	-1.5	2.4	0.9	-0.4
Condit. Reinf. lever reinforcers received	0.4	0.5	0.7	0.5	0.9	-0.8	0.8	0.7	0.4
Pavlov. Cond. lever latency	0.9	1.2	3.0	-1.4	0.2	-0.4	-1.0	1.0	1.7
Pavlov. Cond. magazine entry latency	1.4	1.6	3.5	1.9	0.9	-0.7	1.9	0.1	-1.2
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.4	0.1	-0.1	0.4	0.0	-0.2
Pavlov. Cond. index score	0.7	0.9	1.9	1.4	0.3	-0.1	1.2	-0.4	-1.3
Pavlov. Cond. latency score	0.5	0.7	1.4	1.2	0.4	-0.1	1.1	-0.3	-1.1
Pavlov. Cond. lever contacts	0.8	1.1	2.8	1.7	0.2	-0.1	1.3	-0.6	-1.4
Pavlov. Cond. magazine entry number	0.3	0.4	0.9	-0.9	-0.1	-0.1	-0.8	0.4	1.0
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.7	0.9	0.0	-0.3	0.6	-0.0	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.5	1.2	0.2	0.0	1.0	-0.5	-1.2
Pavlov. Cond. response bias	0.6	0.8	1.9	1.4	0.2	-0.1	1.2	-0.4	-1.2
Conditioned reinforcement - actives	1.3	1.3	2.4	1.1	1.2	-1.3	1.5	0.9	0.4
Conditioned reinforcement - inactives	0.9	1.1	1.9	0.8	1.2	-1.2	1.4	0.8	0.6
Conditioned locomotion	1.5	1.8	2.9	0.7	1.7	-1.7	1.5	1.4	0.7
Intermittent access intake day 1-15 change	2.2	2.2	5.9	2.4	-0.2	0.2	1.6	-1.1	-1.9
Intermittent access intake escalation	2.9	2.8	8.1	2.8	-0.0	-0.0	2.0	-0.9	-2.0
Intermittent access intake escalation 2	3.3	3.3	9.8	3.1	-0.4	0.2	2.0	-1.0	-2.2
Intermitt. access day 1 inactive lever presses	0.5	0.5	1.1	0.4	1.1	-0.7	1.1	0.3	0.0
Intermitt. access day 15 inactive lever presses	0.9	1.0	2.3	0.6	-0.8	1.0	-0.1	-1.3	-1.5
Intermitt. access escalation Index	1.0	0.9	1.7	-0.2	-1.1	1.1	-0.7	-1.3	-0.9
Intermittent access day 1 total infusions	1.0	1.2	2.6	-0.5	-1.0	1.3	-0.7	-1.6	-1.1
Intermittent access day 15 total infusions	1.9	2.1	4.7	1.5	-0.7	1.0	0.8	-1.9	-2.2
Intermittent access terminal intake (last 3 days)	1.6	1.7	3.9	1.2	-0.8	1.0	0.6	-1.8	-2.0
Intermittent access total infusions	1.3	1.4	3.4	0.7	-0.8	1.1	0.3	-1.8	-1.7
Intermittent access day 1 locomotion	0.3	0.3	1.0	0.2	-0.3	0.5	0.0	-0.6	-1.0
Intermittent access day 15 total locomotion	0.8	0.8	1.8	1.3	0.3	-0.2	1.3	-0.4	-1.1
Intermittent access total locomotion	0.4	0.4	0.9	0.8	0.4	-0.1	0.9	-0.3	-0.9
Intermittent access standard deviation	3.1	3.4	9.2	3.0	0.7	-0.7	2.6	-0.5	-1.7
Cocaine induced anxiety	1.3	1.5	3.3	1.4	1.2	-1.3	1.8	0.9	-0.1
Post-drug Anxiety	0.2	0.2	0.3	0.5	0.3	-0.4	0.6	0.4	0.2
Baseline Anxiety	2.2	2.3	4.2	-1.4	-1.6	1.7	-2.1	-1.3	-0.4
Lifetime Intake	0.8	0.9	2.3	0.5	-0.5	0.8	0.2	-1.5	-1.4
Incentive Sensitization - Responses	0.3	0.3	0.8	0.8	-0.1	-0.2	0.9	-0.2	-0.1
Incentive Sensitization - Breakpoint	0.3	0.3	1.0	0.8	-0.0	-0.3	1.0	-0.1	0.0
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	0.1	0.1	0.1	0.2	-0.5	-0.4
Progressive ratio test 1 breakpoint	0.1	0.1	0.1	0.0	0.3	0.0	0.3	-0.4	-0.3
Progressive ratio test 1 inactive lever presses	0.4	0.4	0.8	0.9	0.8	-0.5	0.9	0.1	-0.5
Progressive ratio test 2 active lever presses	0.4	0.4	0.9	0.9	0.1	-0.1	1.0	-0.5	-0.6
Progressive ratio test 2 breakpoint	0.2	0.2	0.4	0.5	-0.1	0.1	0.5	-0.6	-0.4
Progressive ratio test 2 inactive lever presses	1.9	2.2	5.8	2.4	0.5	-0.5	2.0	-0.6	-1.5
Total sessions with >9 infusions	0.5	0.6	1.1	1.1	0.1	0.1	0.8	-0.8	-0.9
Short access day 1 total inactive lever presses	1.4	1.6	3.5	1.3	-0.8	1.0	0.3	-1.7	-1.9
Short access day 10 total inactive lever presses	0.4	0.4	1.0	1.0	0.3	-0.2	0.8	-0.3	-0.8
Short access day 1 total infusions	0.2	0.3	0.5	0.6	-0.1	0.1	0.4	-0.7	-0.7
Short access day 10 total infusions	0.1	0.1	0.2	-0.3	0.5	-0.0	0.4	-0.4	-0.3
Short access total infusions	0.3	0.4	1.4	-0.0	-0.2	0.5	0.0	-1.2	-0.8
Short access day 1 locomotion	0.2	0.2	0.3	-0.6	0.3	-0.2	-0.3	0.4	0.6
Short access day 10 total locomotion	2.1	2.3	3.7	1.1	1.7	-1.7	1.9	1.6	0.5
Short access total locomotion	1.8	1.8	3.0	0.4	1.7	-1.6	1.5	1.5	0.8
Compulsive drug intake	0.3	0.3	0.6	-0.1	0.4	-0.6	0.4	0.8	0.7
One hour access (0.3 mA shock)	1.2	1.4	3.5	1.6	0.9	-0.8	1.9	0.2	-0.7
One hour access (shock baseline)	0.8	0.9	1.9	1.3	0.3	0.0	1.2	-0.7	-1.4
Number of responses in last shaping day	0.4	0.4	1.1	1.1	0.1	0.0	0.5	-0.3	-0.9
Context. condit. distance diff. score	0.1	0.2	0.3	0.0	-0.6	0.5	-0.3	-0.5	-0.4
Locomotion velocity, session 1	0.4	0.4	0.6	0.8	0.4	-0.7	0.8	0.8	0.3
Locomotion distance, session 1	2.9	3.8	7.4	2.5	1.8	-2.0	2.7	1.4	-0.2
Locomotion velocity, session 2	1.3	1.6	2.2	1.1	1.4	-1.5	1.5	1.3	0.6
Locomotion distance, session 2	2.9	4.2	6.5	1.9	2.2	-2.4	2.5	1.9	0.6
Locomotion velocity, session 3	0.6	0.7	1.6	0.6	1.2	-0.8	1.1	0.5	-0.4
Locomotion distance, session 3	0.0	0.0	0.0	-0.0	0.2	0.0	0.0	-0.1	-0.2
Stereotopy head waving bouts, day 3	0.5	0.6	1.5	0.6	-0.4	0.6	0.2	-1.0	-1.2
Stereotopy head waving duration, day 3	0.2	0.2	0.6	0.4	-0.3	0.4	0.1	-0.6	-0.8
Locomotion velocity, session 7	0.4	0.4	0.9	-0.7	0.9	-0.6	0.1	0.7	0.5
Locomotion distance, session 7	0.1	0.1	0.2	-0.3	-0.1	0.4	-0.4	-0.4	-0.4
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	0.1	-0.3	0.2	-0.0	-0.2	-0.3
Stereotopy head waving duration, day 7	0.3	0.4	1.0	1.0	-0.0	-0.0	0.8	-0.3	-0.8
Locomotion velocity, session 8	0.5	0.6	0.9	0.5	0.9	-1.0	0.7	1.0	0.5
Locomotion distance, session 8	0.7	1.0	1.9	1.1	1.1	-1.1	1.4	0.8	-0.0
Degree of sensitization distance	0.2	0.2	0.4	0.6	-0.0	0.0	0.4	-0.3	-0.6
Degree of sensitization stereotypy	0.1	0.1	0.2	-0.1	-0.4	0.4	-0.3	-0.3	-0.2
Condit. Reinf. active minus inactive responses	0.9	1.0	2.0	0.5	-0.9	1.0	-0.0	-1.4	-1.4
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.3	-0.1	-0.7	0.9	-0.3	-1.1	-1.0
Condit. Reinf. active responses	0.0	0.0	0.0	0.1	0.1	-0.0	0.2	-0.1	-0.2
Condit. Reinf. inactive responses	0.8	1.0	1.8	0.1	1.1	-1.2	0.5	1.3	1.0
Incentive salience index mean	0.5	0.6	1.4	1.2	0.5	-0.6	1.2	0.0	-0.5
Condit. Reinf. lever presses	1.6	2.2	3.4	1.1	1.7	-1.8	1.7	1.5	0.8
Time in familiar zone, hab. session 1	1.0	0.9	2.5	1.6	0.4	-0.4	1.3	-0.1	-1.0
Time in novel zone, hab. session 1	0.5	0.5	0.9	-0.9	0.5	-0.4	-0.4	0.8	0.9
Total zone transitions, hab. session 1	0.1	0.2	0.3	0.3	0.5	-0.4	0.5	0.4	0.0
Total locomotion distance, hab. session 1	0.8	1.1	1.9	0.1	1.4	-1.3	0.9	1.3	0.8
Locomotion velocity, hab. session 1	0.5	0.6	1.1	-0.4	0.9	-0.9	0.3	1.0	1.0
Time in familiar zone, hab. session 2	1.0	1.1	2.8	1.7	0.5	-0.4	1.4	-0.1	-1.0
Time in novel zone, hab. session 2	0.5	0.5	1.2	-1.1	-0.4	0.4	-1.0	-0.1	0.5
Total zone transitions, hab. session 2	0.5	0.6	1.8	1.3	0.4	-0.6	1.1	0.1	-0.4
Total locomotion distance, hab. session 2	2.4	3.2	4.9	1.7	1.9	-2.2	2.2	1.6	0.6
Locomotion velocity, hab. session 2	2.3	3.1	4.9	1.2	2.0	-2.2	1.9	1.8	1.1
Novel to familiar place preference ratio	0.0	0.0	0.1	-0.3	-0.2	0.2	-0.3	-0.1	-0.1
Novelty place preference	0.2	0.2	0.5	-0.7	-0.4	0.5	-0.7	-0.2	0.1
Time in novel zone, NPP test	0.3	0.3	0.5	-0.6	-0.6	0.6	-0.7	-0.4	-0.1
Total zone transitions, NPP test	0.7	1.1	1.5	1.1	0.9	-1.2	1.2	1.1	0.6
Total locomotion distance, NPP test	3.0	4.2	6.3	1.7	2.3	-2.5	2.4	2.1	1.0
Locomotion velocity, NPP test	3.2	4.5	7.0	1.3	2.4	-2.6	2.2	2.4	1.4
Pavlov. Cond. lever latency	1.1	1.4	2.0	-0.8	-1.3	1.4	-1.3	-1.3	-0.7
Pavlov. Cond. magazine entry latency	0.5	0.6	1.3	0.3	-0.7	0.9	-0.2	-1.0	-1.1
Pavlov. Cond. change in total contacts	0.4	0.5	0.9	-0.9	0.5	-0.4	-0.4	0.7	0.9
Pavlov. Cond. index score	0.1	0.2	0.3	0.5	0.4	-0.4	0.6	0.2	-0.1
Pavlov. Cond. latency score	0.3	0.3	0.5	0.5	0.7	-0.7	0.7	0.5	0.2
Pavlov. Cond. lever contacts	1.1	1.3	1.9	0.7	1.3	-1.4	1.2	1.2	0.8
Pavlov. Cond. magazine entry number	0.6	0.7	1.2	0.1	1.0	-1.1	0.7	1.0	0.9
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.2	-0.5	0.4	-0.7	0.0	0.9	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.5	0.7	0.3	-0.4	0.7	0.1	-0.2
Pavlov. Cond. response bias	0.1	0.1	0.2	0.5	-0.2	0.2	0.2	-0.4	-0.5
Bone: apparent density	1.1	1.8	4.3	1.2	-1.1	1.2	0.2	-1.6	-2.1
Bone surface	1.3	2.3	5.6	2.4	-0.2	0.1	1.6	-1.0	-2.1
Bone volume	0.9	1.6	3.9	1.6	-0.7	0.7	0.7	-1.2	-2.0
Bone: connectivity density	2.0	3.1	7.1	2.4	-0.8	0.8	1.3	-1.7	-2.7
Bone: cortical apparent density	1.7	2.2	5.5	-2.3	-1.0	1.2	-2.2	-0.4	0.7
Bone: cortical area	5.3	8.0	14.9	-2.8	-3.2	3.1	-3.9	-2.2	-0.1
Bone: cortical porosity	1.6	1.7	2.9	0.8	-1.4	1.4	-0.2	-1.6	-1.7
Bone: cortical porosity	2.0	2.1	3.3	0.0	-1.8	1.8	-1.0	-1.8	-1.4
Bone: cortical thickness	11.0	18.2	33.5	-4.2	-4.8	4.8	-5.8	-3.4	-0.2
Bone: cortical thickness	4.5	5.3	9.7	-2.6	-2.1	2.6	-3.1	-1.8	-0.6
Bone: cortical tissue density	1.5	1.9	5.0	-2.2	-0.8	1.0	-2.0	-0.3	0.8
Bone: elastic displacement	1.0	1.1	2.5	-1.6	-0.7	0.8	-1.5	-0.3	0.6
Bone: elastic work	3.4	4.5	6.9	-1.5	-2.6	2.5	-2.6	-2.0	-0.7
Bone: endosteal estimation	1.9	4.0	10.4	3.2	1.1	-1.1	2.9	0.0	-1.7
Bone: endosteal perimeter	1.3	2.6	6.2	2.5	1.1	-1.2	2.4	0.3	-0.9
Bone: final force	3.6	5.8	9.8	-2.1	-2.8	2.8	-3.1	-2.2	-0.6
Bone: final moment	3.1	5.1	7.8	-1.8	-2.7	2.7	-2.8	-2.2	-0.8
Bone: marrow area	1.8	4.0	10.0	3.2	1.1	-1.2	2.9	0.1	-1.6
Bone: maximum diameter	0.3	0.5	0.8	-0.6	-0.8	0.8	-0.9	-0.7	-0.1
Bone: maximum force	2.9	5.1	7.9	-1.5	-2.8	2.7	-2.7	-2.1	-0.9
Bone: maximum moment	2.5	4.4	7.2	-1.0	-2.7	2.6	-2.3	-2.2	-1.2
Bone: minimum diameter	0.6	1.2	2.0	0.1	-1.4	1.3	-0.8	-1.3	-1.0
Bone: periosteal estimation	0.5	0.9	1.6	0.2	-1.2	1.1	-0.5	-1.2	-1.0
Bone: periosteal perimeter	0.1	0.2	0.5	0.0	-0.7	0.5	-0.4	-0.5	-0.0
Bone: post-yield work	1.1	1.5	3.1	1.8	-1.0	0.7	0.7	-1.2	-1.6
Bone: stiffness	2.1	3.2	5.5	-1.5	-2.1	2.1	-2.3	-1.6	-0.5
Bone: tissue strength	0.1	0.1	0.3	0.5	-0.1	-0.0	0.2	-0.0	-0.1
Bone: trabecular number	1.4	2.2	5.3	1.3	-1.2	1.3	0.2	-1.7	-2.3
Bone: trabecular spacing	1.6	2.0	4.8	-2.2	0.2	-0.2	-1.5	0.8	2.1
Bone: trabecular thickness	1.3	1.5	2.5	-0.0	-1.5	1.6	-1.0	-1.4	-1.3
Bone: trabecular tissue density	0.2	0.3	0.6	-0.8	-0.2	0.2	-0.7	0.3	0.7
Breakpoint value in progressive ratio session	1.4	1.6	3.0	-0.7	-1.7	1.4	-1.7	-1.2	-0.1
Distance traveled before self-admin	0.3	0.3	0.9	0.0	0.3	-0.7	0.1	0.9	0.8
Distance traveled after self-admin	2.1	2.3	5.7	-2.4	-0.8	0.4	-1.9	0.3	1.9
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	-0.5	0.4	-0.1	-0.2	0.3	0.0
Delta time in open arm before/after self-admin	1.4	1.4	2.4	-1.0	-1.4	1.3	-1.5	-1.0	-0.2
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	-0.1	0.2	-0.1	-0.2	0.1	0.1
Extinction: sum of active levers before priming	0.3	0.3	0.6	-0.8	-0.5	0.1	-0.8	0.3	0.7
Active lever presses in extinction session 6	2.1	2.0	4.3	-0.1	-2.1	1.6	-1.3	-1.6	-0.9
Delta distance traveled before/after self-admin	1.3	1.4	4.2	-2.0	-0.4	0.4	-1.4	-0.1	1.3
Delta ambulatory time before/after self-admin	1.0	1.1	3.5	-1.9	-0.3	0.5	-1.2	-0.2	1.0
Time in closed arm before self-admin	0.1	0.1	0.3	0.4	0.0	0.2	0.2	-0.3	-0.6
Time in closed arm after self-admin	0.1	0.1	0.3	-0.5	0.1	0.3	-0.3	-0.1	-0.2
Time in open arm before self-admin	0.5	0.6	0.9	0.2	0.7	-0.9	0.7	0.8	1.0
Time in open arm after self-admin	0.8	0.9	2.1	-1.4	-0.5	0.1	-1.1	0.2	1.4
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	-0.1	-0.3	0.0	-0.3	0.2	0.3
Time to tail flick, vehicle, before self-admin	2.9	2.9	5.8	-1.8	-1.9	1.7	-2.4	-1.2	0.5
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	0.1	-0.0	0.0	0.1	-0.2	-0.3
Time to tail flick, test, before self-admin	1.6	1.5	3.8	1.6	-0.8	0.7	0.7	-1.1	-1.9
Time to tail flick, test, after self-admin	3.0	3.0	6.4	2.3	-1.1	1.0	0.9	-1.9	-2.5
Delta time to tail flick, vehicle, before/after SA	1.3	1.3	2.5	1.2	1.3	-1.2	1.6	0.8	-0.4
Delta time to tail flick, test, before/after SA	0.4	0.4	0.9	1.0	0.3	-0.3	0.9	-0.3	-0.4
Ambulatory time before self-admin	0.1	0.1	0.4	0.2	0.0	-0.4	-0.1	0.6	0.4
Ambulatory time after self-admin	1.8	2.0	4.9	-2.2	-0.7	0.5	-1.9	0.3	1.5
Total heroin consumption	0.3	0.4	1.1	-0.6	-0.7	0.4	-1.0	0.1	0.6
Area under the delay curve	0.4	0.5	0.7	0.7	0.8	-0.8	0.8	0.6	0.1
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	0.3	-0.2	0.0	-0.1	0.1	-0.0
Delay disc. indifference point, 16s delay	1.3	1.3	2.2	0.7	1.5	-1.5	1.2	1.2	0.7
Delay disc. indifference point, 2s delay	1.7	1.9	3.7	1.7	1.4	-1.4	1.9	0.8	-0.3
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.4	0.3	-0.5	0.4	0.3	0.3
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	0.3	0.3	-0.3	0.3	0.1	-0.2
Delay disc. indifference point, 8s delay	0.1	0.1	0.4	0.6	0.0	-0.0	0.3	0.0	-0.4
Delay discount exponential model param	0.4	0.4	0.6	-0.6	-0.8	0.8	-0.7	-0.6	-0.1
Delay discount hyperbolic model param	0.5	0.5	0.7	-0.7	-0.8	0.8	-0.8	-0.6	-0.0
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	-0.1	0.3	-0.2	0.1	0.2	0.2
Change in fecal boli incidents, locomotor task	0.7	0.6	1.1	-0.5	-1.0	1.0	-0.8	-0.7	-0.6
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.4	-0.3	0.2	0.3	-0.2	-0.3
Bouts of movement, locomotor time 1	0.7	0.8	1.7	-0.6	0.9	-0.9	0.0	1.0	1.3
Total resting periods, locomotor time 1	0.6	0.7	1.3	-0.5	0.9	-0.9	0.2	1.0	1.2
Rest time, locomotor task time 1	0.9	1.0	2.4	1.6	0.3	-0.1	1.2	-0.3	-1.4
Distance moved, locomotor task time 1	1.7	1.8	4.1	-2.0	0.3	-0.4	-1.3	0.9	2.0
Vertical activity count, locomotor time 1	0.1	0.1	0.2	0.0	-0.2	0.3	-0.0	-0.4	-0.3
Time >=10cm from walls, locomotor time 2	1.8	1.9	2.9	0.9	-1.6	1.5	-0.3	-1.6	-1.7
Bouts of movement, locomotor time 2	0.1	0.1	0.6	-0.7	0.0	0.1	-0.4	0.1	0.3
Total resting periods, locomotor time 2	0.1	0.2	0.6	-0.8	-0.0	0.1	-0.4	0.2	0.4
Rest time, locomotor task time 2	0.2	0.3	0.7	-0.9	0.4	-0.1	-0.3	0.6	0.4
Distance moved, locomotor task time 2	0.5	0.6	1.2	1.1	0.6	-0.9	1.0	0.3	0.2
Vertical activity count, locomotor time 2	1.2	1.3	4.1	2.0	0.4	-0.7	1.7	0.0	-0.6
Weight adjusted by age	0.6	0.7	1.2	-0.4	-1.1	0.9	-1.0	-0.8	-0.2
Seeking ratio, delayed vs. immediate footshock	1.1	1.3	2.5	0.8	-1.2	1.1	-0.0	-1.4	-1.6
Locomotion in novel chamber	1.8	2.3	4.6	-2.1	-1.4	1.4	-2.1	-0.7	0.6
Locomotion in novel chamber post-restriction	0.1	0.1	0.3	-0.2	-0.3	-0.0	-0.4	0.2	0.6
Progressive ratio	0.1	0.1	0.2	-0.3	0.1	-0.2	-0.0	0.1	0.5
Food seeking constrained by brief footshock	1.8	2.2	3.7	0.4	1.9	-1.9	1.4	1.8	1.1
Seeking ratio, punishment vs. effort	1.0	1.2	2.0	0.7	1.4	-1.3	1.1	1.3	0.3
Run reversals in cocaine runway, females	0.3	0.3	0.7	0.5	-0.5	0.6	0.1	-0.5	-0.8
Run reversals in cocaine runway, males	0.2	0.2	0.7	-0.5	-0.1	-0.1	-0.4	0.5	0.9
Latency to leave start box in cocaine runway	6.6	7.2	11.3	-0.7	-3.4	3.3	-2.4	-3.1	-2.1
Latency to leave start box in cocaine runway, F	6.6	7.3	11.5	-0.1	-3.4	3.3	-2.1	-3.2	-2.5
Latency to leave start box in cocaine runway, M	0.8	0.8	1.3	-1.0	-0.9	1.0	-1.1	-0.7	0.0
Cd content in liver	3.0	3.2	6.2	0.4	-2.2	2.0	-0.8	-2.5	-1.9
Co content in liver	0.3	0.3	0.9	-0.0	0.4	-0.7	0.2	0.7	0.9
Cu content in liver	0.2	0.2	0.3	0.3	0.4	-0.6	0.5	0.4	0.2
Fe content in liver	0.4	0.5	1.5	1.2	0.1	-0.4	1.0	0.1	-0.3
K content in liver	2.3	2.3	4.3	0.5	1.5	-1.9	1.2	2.1	1.5
Mg content in liver	0.2	0.2	0.5	-0.1	0.3	-0.5	0.1	0.7	0.6
Mn content in liver	3.3	3.8	7.0	-1.2	1.9	-1.9	0.3	2.6	2.7
Na content in liver	2.1	2.2	4.0	1.7	1.3	-1.7	2.0	1.4	0.4
Rb content in liver	1.9	2.4	3.7	-1.4	-1.7	1.8	-1.9	-1.3	-0.6
Se content in liver	0.8	1.0	1.6	-1.0	-0.9	1.2	-1.3	-1.1	-0.4
Sr content in liver	1.9	1.8	3.6	1.7	1.3	-1.4	1.9	0.8	-0.0
Zn content in liver	1.4	1.5	2.5	0.5	-1.6	1.4	-0.6	-1.6	-1.2