Zfp950

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain isoform ratio ENSRNOT00000047883 0.04 0.03 1.1e-05 0.03 0.05 0.04 0.05 5.1e-04 9.3e-06 7.1e-05 4.0e-05
2 Liver gene expression ENSRNOG00000032668 0.03 0.02 4.1e-03 0.01 0.01 0.01 0.01 7.7e-03 1.6e-02 1.5e-02 1.4e-02
3 NAcc gene expression ENSRNOG00000032668 0.05 0.04 4.0e-03 0.01 0.02 0.01 0.02 2.5e-02 2.1e-02 2.8e-02 7.3e-03
4 PL intron excision ratio chr1:260237329:260247276 0.03 0.02 7.7e-03 0.01 0.02 0 0.01 2.8e-02 1.2e-02 2.6e-01 7.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail32.7106.1127.89.3-11.310.310.2
BMI without tail22.246.357.06.2-7.66.27.2
Body weight29.8126.2152.810.0-12.411.211.2
Epididymis fat weight36.585.2106.88.1-10.38.79.6
Glucose6.19.316.43.1-3.01.54.1
Heart weight9.213.115.73.6-3.83.04.0
Left kidney weight14.040.158.05.6-6.77.65.1
Right kidney weight13.538.557.65.6-6.57.64.8
Tail length1.13.34.81.7-2.11.22.2
Length with tail3.613.015.83.2-4.03.43.8
Length without tail5.111.213.82.7-3.73.73.1
Liver weight, left5.99.611.62.8-3.42.83.4
Liver weight, right10.617.624.13.4-4.93.94.4
Parametrial fat weight25.850.463.26.4-7.96.57.4
Retroperitoneal fat weight43.2143.0176.810.6-13.311.512.2
Intraocular pressure0.20.30.7-0.50.1-0.80.5
Extensor digitorum longus weight2.59.912.22.7-3.53.33.1
Soleus weight3.510.312.93.6-2.93.52.7
Tibialis anterior weight0.41.41.90.9-1.41.31.1
Tibia length0.30.91.20.8-1.11.00.9
Number of licking bursts0.20.20.4-0.1-0.3-0.60.6
Food consumed during 24 hour testing period0.80.91.60.6-1.31.20.7
Times rat made contact with spout1.92.13.41.1-1.81.41.4
Mean time between licks in bursts0.30.41.4-1.2-0.3-0.4-0.1
Mean num. licks in bursts0.91.02.70.9-0.81.70.2
Std. dev. time between licks in bursts1.31.53.3-1.80.7-0.9-1.2
Water consumed over 24 hours0.30.40.80.6-0.60.90.2
Indifference point 0 sec5.48.79.73.0-3.12.63.1
Indifference point AUC0.20.30.80.90.2-0.20.5
Indifference point function ln k0.71.02.50.3-1.11.60.2
Indifference point function log k0.71.02.50.3-1.11.60.2
Delay discounting total patch changes 0 sec6.710.811.83.4-3.42.93.4
Delay discounting total patch changes 12 sec3.54.76.02.3-2.21.52.4
Delay discounting total patch changes 18 sec2.22.83.41.7-1.71.51.8
Delay discounting total patch changes 24 sec0.30.40.80.9-0.40.20.8
Delay discounting total patch changes 6 sec4.16.27.52.7-2.42.02.7
Delay discounting time to switch 0 sec1.42.22.7-1.61.4-1.4-1.4
Delay discounting water rate 0 sec3.14.95.82.4-2.12.32.1
Delay discounting water rate 12 sec2.94.45.62.1-2.01.82.4
Delay discounting water rate 18 sec1.62.13.41.6-1.21.80.9
Delay discounting water rate 24 sec5.17.110.62.9-2.43.32.0
Delay discounting water rate 6 sec2.84.06.12.0-2.02.51.5
Locomotor activity0.00.10.2-0.40.2-0.1-0.2
Locomotor testing distance0.30.50.9-0.60.7-0.1-0.9
Locomotor testing rearing0.10.10.30.60.20.20.0
Light reinforcement 10.10.20.5-0.00.10.6-0.7
Light reinforcement 20.30.30.5-0.70.6-0.6-0.5
Reaction time number correct0.40.61.00.7-0.80.51.0
Reaction time mean minus median0.10.20.30.40.5-0.6-0.1
Reaction time mean minus median AUC0.40.51.01.00.7-0.50.0
Reaction time num false alarms1.01.42.90.5-1.51.70.5
Reaction time num false alarms AUC1.31.83.00.8-1.61.70.8
Reaction time trials correct on left0.40.61.00.7-0.80.51.0
Reaction time trials on left0.40.61.00.7-0.80.51.0
Reaction time mean2.73.76.1-0.92.5-2.4-1.5
Reaction time mean AUC3.04.06.7-0.92.6-2.4-1.7
Median of all reaction times3.34.57.4-1.12.7-2.5-1.7
Reaction time omissions0.60.81.9-0.70.8-1.4-0.4
Reaction time false alarm rate0.50.71.50.3-1.11.20.3
Reaction time premature initiation rate0.10.20.40.10.6-0.1-0.5
Reaction time premature initiations0.10.20.50.7-0.10.40.3
Std. dev. reaction times0.20.30.80.20.7-0.9-0.1
Reaction time trials completed0.40.61.00.7-0.80.51.0
Reaction time trials AUC0.81.11.60.9-1.20.81.3
Social response proportion0.60.61.5-0.1-0.91.20.1
Social responses2.12.73.71.3-1.91.51.8
Social time0.10.20.40.5-0.40.20.6
Conditioned locomotion0.10.10.2-0.10.5-0.2-0.2
Cocaine response after cond. corrected2.32.56.4-1.41.30.4-2.5
Cocaine response after cond. not corrected3.13.47.2-1.91.6-0.2-2.7
Cocaine response before conditioning0.40.51.0-0.8-0.1-1.00.3
Saline control response0.10.20.30.30.5-0.2-0.5
Condit. Reinf. active minus inactive responses2.02.54.31.1-1.81.02.1
Condit. Reinf. active-inactive response ratio2.72.85.11.6-1.60.92.3
Condit. Reinf. active responses2.23.05.21.2-2.11.12.3
Condit. Reinf. inactive responses0.81.01.80.4-1.30.71.2
Condit. Reinf. lever presses1.82.43.21.2-1.81.51.7
Condit. Reinf. lever reinforcers received1.21.72.90.7-1.70.81.7
Pavlov. Cond. lever latency1.11.52.6-0.51.6-1.1-1.3
Pavlov. Cond. magazine entry latency0.50.61.4-0.70.5-1.2-0.1
Pavlov. Cond. change in total contacts0.20.30.60.2-0.80.30.8
Pavlov. Cond. index score0.10.10.3-0.1-0.50.10.5
Pavlov. Cond. latency score0.10.20.3-0.0-0.60.30.5
Pavlov. Cond. lever contacts0.60.81.40.4-1.20.81.0
Pavlov. Cond. magazine entry number0.10.10.30.3-0.30.60.0
Pavlov. Cond. intertrial magazine entries4.35.67.72.4-2.32.81.9
Pavlov. Cond. lever-magazine prob. diff.0.00.10.1-0.2-0.3-0.10.4
Pavlov. Cond. response bias0.30.40.7-0.2-0.90.20.8
Conditioned reinforcement - actives4.64.65.5-2.42.1-1.8-2.2
Conditioned reinforcement - inactives0.50.50.6-0.80.8-0.7-0.7
Conditioned locomotion3.03.65.2-2.31.7-1.3-2.2
Intermittent access intake day 1-15 change0.10.10.20.4-0.10.00.4
Intermittent access intake escalation0.10.10.10.30.10.30.0
Intermittent access intake escalation 20.30.30.50.5-0.50.70.6
Intermitt. access day 1 inactive lever presses0.80.81.11.0-0.80.71.1
Intermitt. access day 15 inactive lever presses1.41.63.41.8-0.71.01.2
Intermitt. access escalation Index0.10.10.1-0.4-0.20.2-0.2
Intermittent access day 1 total infusions0.60.70.9-0.71.0-0.9-0.8
Intermittent access day 15 total infusions0.30.30.7-0.30.8-0.5-0.6
Intermittent access terminal intake (last 3 days)0.20.20.4-0.10.7-0.4-0.3
Intermittent access total infusions1.01.11.7-0.81.3-1.1-1.0
Intermittent access day 1 locomotion2.93.04.0-1.51.9-1.4-2.0
Intermittent access day 15 total locomotion0.10.10.30.10.2-0.50.4
Intermittent access total locomotion1.31.52.0-1.11.4-1.0-1.4
Intermittent access standard deviation0.40.41.0-0.50.5-1.0-0.1
Cocaine induced anxiety3.23.75.0-2.11.9-1.4-2.2
Post-drug Anxiety1.01.11.3-1.11.0-1.1-0.9
Baseline Anxiety1.31.42.71.1-1.10.41.7
Lifetime Intake1.41.62.5-1.01.6-1.2-1.3
Incentive Sensitization - Responses1.81.82.61.6-1.01.11.5
Incentive Sensitization - Breakpoint1.51.52.11.4-1.01.11.4
Progressive ratio test 1 active lever presses1.51.52.4-0.91.5-1.1-1.3
Progressive ratio test 1 breakpoint1.41.52.6-0.71.6-1.2-1.2
Progressive ratio test 1 inactive lever presses0.70.81.0-0.81.0-0.6-1.0
Progressive ratio test 2 active lever presses0.30.41.01.0-0.10.40.5
Progressive ratio test 2 breakpoint0.30.41.01.0-0.10.40.5
Progressive ratio test 2 inactive lever presses0.10.10.30.1-0.30.50.1
Total sessions with >9 infusions0.80.81.6-0.41.2-0.3-1.3
Short access day 1 total inactive lever presses1.01.12.2-1.50.7-0.4-1.2
Short access day 10 total inactive lever presses3.33.66.41.7-1.92.51.2
Short access day 1 total infusions1.61.72.5-1.11.5-0.8-1.6
Short access day 10 total infusions2.32.63.4-1.31.8-1.7-1.5
Short access total infusions2.12.33.5-1.11.9-1.3-1.7
Short access day 1 locomotion0.60.61.2-0.41.1-0.6-0.9
Short access day 10 total locomotion0.80.91.2-0.81.1-0.9-1.0
Short access total locomotion2.12.23.8-0.62.0-1.0-1.8
Compulsive drug intake0.20.20.4-0.2-0.60.50.1
One hour access (0.3 mA shock)0.50.61.2-0.70.8-1.1-0.4
One hour access (shock baseline)0.91.01.4-0.71.2-1.2-0.8
Number of responses in last shaping day1.01.01.4-1.01.0-0.9-1.2
Context. condit. distance diff. score0.00.10.2-0.40.1-0.2-0.1
Locomotion velocity, session 11.31.41.6-1.31.2-1.1-1.1
Locomotion distance, session 12.53.24.4-1.52.1-1.5-2.0
Locomotion velocity, session 21.11.32.3-1.01.2-0.5-1.5
Locomotion distance, session 20.30.51.20.6-0.51.10.1
Locomotion velocity, session 33.13.65.0-1.62.2-1.8-1.8
Locomotion distance, session 31.21.31.6-1.11.3-0.9-1.3
Stereotopy head waving bouts, day 30.30.40.6-0.20.8-0.5-0.7
Stereotopy head waving duration, day 30.40.51.10.11.0-0.8-0.6
Locomotion velocity, session 70.20.20.3-0.40.5-0.5-0.2
Locomotion distance, session 70.40.51.10.2-0.81.10.3
Stereotopy head waving bouts, day 71.01.23.5-0.01.1-1.90.3
Stereotopy head waving duration, day 71.82.26.2-0.31.5-2.50.1
Locomotion velocity, session 81.72.03.6-1.91.1-1.1-1.4
Locomotion distance, session 80.40.61.4-1.20.3-0.2-1.0
Degree of sensitization distance2.82.94.41.2-2.11.91.4
Degree of sensitization stereotypy0.90.92.50.40.6-1.60.8
Condit. Reinf. active minus inactive responses1.31.53.6-1.90.5-0.5-1.3
Condit. Reinf. active-inactive response ratio1.61.73.3-1.80.9-1.0-1.3
Condit. Reinf. active responses0.50.71.2-0.7-1.01.1-0.0
Condit. Reinf. inactive responses2.63.14.90.9-2.22.21.3
Incentive salience index mean0.80.92.4-1.50.20.0-1.1
Condit. Reinf. lever presses0.30.40.9-0.90.10.3-0.9
Time in familiar zone, hab. session 12.01.92.71.6-1.20.81.6
Time in novel zone, hab. session 14.44.36.2-2.51.8-2.1-1.9
Total zone transitions, hab. session 10.10.10.30.40.5-0.2-0.3
Total locomotion distance, hab. session 10.20.30.5-0.60.4-0.7-0.4
Locomotion velocity, hab. session 10.10.10.2-0.50.0-0.2-0.3
Time in familiar zone, hab. session 20.60.71.4-1.20.2-1.10.0
Time in novel zone, hab. session 20.30.30.60.8-0.30.70.2
Total zone transitions, hab. session 20.10.10.30.60.00.20.1
Total locomotion distance, hab. session 20.40.50.80.5-0.90.60.8
Locomotion velocity, hab. session 20.50.70.90.8-0.90.70.9
Novel to familiar place preference ratio0.20.20.7-0.8-0.4-0.20.0
Novelty place preference0.20.20.7-0.8-0.3-0.3-0.1
Time in novel zone, NPP test0.40.40.9-0.9-0.5-0.50.3
Total zone transitions, NPP test0.50.71.80.7-0.81.30.3
Total locomotion distance, NPP test0.20.30.70.2-0.60.80.0
Locomotion velocity, NPP test0.30.51.40.3-0.41.2-0.4
Pavlov. Cond. lever latency0.60.81.2-0.80.9-1.1-0.7
Pavlov. Cond. magazine entry latency0.81.01.40.7-1.21.11.0
Pavlov. Cond. change in total contacts2.62.74.11.1-2.01.22.0
Pavlov. Cond. index score1.21.62.20.9-1.51.21.3
Pavlov. Cond. latency score1.01.31.70.9-1.31.11.2
Pavlov. Cond. lever contacts1.01.21.61.0-1.20.91.3
Pavlov. Cond. magazine entry number1.01.32.1-0.61.4-1.2-1.1
Pavlov. Cond. intertrial magazine entries2.42.95.21.1-2.02.31.1
Pavlov. Cond. lever-magazine prob. diff.1.31.62.40.9-1.51.21.4
Pavlov. Cond. response bias0.91.21.50.8-1.21.11.0
Bone: apparent density3.25.49.01.3-3.02.42.2
Bone surface2.95.27.91.5-2.82.32.2
Bone volume5.99.913.42.5-3.73.33.0
Bone: connectivity density0.20.30.7-0.2-0.80.50.5
Bone: cortical apparent density7.29.413.8-2.83.3-2.2-3.7
Bone: cortical area13.220.023.44.2-4.84.34.6
Bone: cortical porosity1.11.21.90.8-1.30.81.4
Bone: cortical porosity2.22.33.71.3-1.71.01.9
Bone: cortical thickness8.413.915.53.6-3.93.93.4
Bone: cortical thickness6.37.411.13.3-2.32.72.4
Bone: cortical tissue density8.210.715.2-3.03.5-2.4-3.9
Bone: elastic displacement0.20.20.70.8-0.10.40.3
Bone: elastic work2.43.25.92.4-1.11.91.4
Bone: endosteal estimation2.14.55.41.9-2.32.02.3
Bone: endosteal perimeter3.36.88.92.7-2.62.13.0
Bone: final force9.215.116.63.8-4.14.03.7
Bone: final moment9.816.218.23.8-4.34.13.9
Bone: marrow area2.45.16.02.0-2.52.12.4
Bone: maximum diameter5.910.814.83.0-3.62.63.8
Bone: maximum force8.013.916.33.4-4.04.03.4
Bone: maximum moment8.314.417.23.4-4.24.13.5
Bone: minimum diameter6.712.515.23.2-3.83.13.9
Bone: periosteal estimation8.717.720.73.9-4.64.14.3
Bone: periosteal perimeter10.617.520.84.2-4.33.64.6
Bone: post-yield work1.21.63.00.4-1.71.41.1
Bone: stiffness3.65.87.42.1-2.72.72.1
Bone: tissue strength0.60.61.3-0.70.7-1.2-0.3
Bone: trabecular number1.72.64.01.1-2.01.51.7
Bone: trabecular spacing3.54.65.3-2.32.1-2.2-1.9
Bone: trabecular thickness12.114.716.23.8-4.03.54.0
Bone: trabecular tissue density1.62.33.5-1.81.3-0.9-1.9
Breakpoint value in progressive ratio session1.92.24.01.7-1.20.52.0
Distance traveled before self-admin0.91.02.60.11.6-0.5-1.0
Distance traveled after self-admin1.71.93.3-0.91.8-1.0-1.6
Delta time in closed arm before/after self-admin0.30.30.5-0.5-0.10.6-0.7
Delta time in open arm before/after self-admin0.50.51.3-0.2-0.8-0.31.1
Diff in mean of infusions in LGA sessions0.40.51.10.8-0.1-0.51.1
Extinction: sum of active levers before priming0.20.20.7-0.20.4-0.80.2
Active lever presses in extinction session 61.71.63.41.9-0.80.61.5
Delta distance traveled before/after self-admin0.70.81.5-1.20.6-0.6-1.0
Delta ambulatory time before/after self-admin0.60.71.4-1.20.5-0.5-0.9
Time in closed arm before self-admin0.30.40.9-0.00.7-0.9-0.1
Time in closed arm after self-admin0.40.40.8-0.40.9-0.5-0.8
Time in open arm before self-admin0.70.81.0-0.81.0-0.8-0.9
Time in open arm after self-admin0.40.41.2-0.50.1-1.10.6
Sum of active levers in priming session hrs 5-60.00.00.1-0.10.1-0.30.1
Time to tail flick, vehicle, before self-admin0.30.30.6-0.2-0.80.60.3
Time to tail flick, vehicle, after self-admin0.70.80.80.9-0.90.90.9
Time to tail flick, test, before self-admin0.80.81.5-0.41.2-0.5-1.2
Time to tail flick, test, after self-admin0.10.10.3-0.1-0.60.20.4
Delta time to tail flick, vehicle, before/after SA2.22.14.32.1-0.90.71.7
Delta time to tail flick, test, before/after SA2.32.14.10.5-2.01.21.6
Ambulatory time before self-admin0.50.51.40.31.2-0.3-0.7
Ambulatory time after self-admin2.73.04.9-1.22.2-1.3-1.9
Total heroin consumption4.15.07.82.7-1.91.22.8
Area under the delay curve0.50.61.01.00.3-0.70.7
Delay disc. indifference point, 0s delay0.70.71.21.1-0.70.70.8
Delay disc. indifference point, 16s delay0.50.51.10.50.4-1.00.6
Delay disc. indifference point, 2s delay0.30.40.80.40.9-0.7-0.2
Delay disc. indifference point, 24s delay0.40.30.70.90.1-0.40.7
Delay disc. indifference point, 4s delay0.30.30.50.70.3-0.70.6
Delay disc. indifference point, 8s delay0.30.40.70.40.7-0.80.0
Delay discount exponential model param0.60.61.2-1.1-0.40.7-0.8
Delay discount hyperbolic model param0.50.50.9-1.0-0.50.8-0.6
Fecal boli incidents, locomotor time 10.30.30.90.3-0.4-0.31.0
Change in fecal boli incidents, locomotor task0.90.91.60.4-1.21.30.5
Time >=10cm from walls, locomotor time 10.20.20.3-0.60.3-0.5-0.3
Bouts of movement, locomotor time 10.20.30.40.3-0.70.40.7
Total resting periods, locomotor time 10.30.40.60.4-0.80.60.6
Rest time, locomotor task time 11.31.53.90.7-1.22.00.1
Distance moved, locomotor task time 10.60.71.5-0.21.1-1.2-0.4
Vertical activity count, locomotor time 11.11.11.8-0.51.3-1.3-0.8
Time >=10cm from walls, locomotor time 20.20.20.30.3-0.50.60.1
Bouts of movement, locomotor time 20.10.10.1-0.10.4-0.3-0.3
Total resting periods, locomotor time 20.10.10.2-0.10.5-0.4-0.3
Rest time, locomotor task time 20.00.00.1-0.20.1-0.0-0.3
Distance moved, locomotor task time 20.00.00.10.10.20.0-0.3
Vertical activity count, locomotor time 20.20.20.3-0.40.4-0.3-0.6
Weight adjusted by age7.28.19.62.6-3.12.92.7
Seeking ratio, delayed vs. immediate footshock9.210.512.2-3.43.3-2.7-3.5
Locomotion in novel chamber0.60.71.41.1-0.51.20.1
Locomotion in novel chamber post-restriction0.30.30.70.50.50.4-0.8
Progressive ratio2.93.34.9-1.42.2-1.6-2.0
Food seeking constrained by brief footshock7.69.311.4-2.73.4-3.3-2.8
Seeking ratio, punishment vs. effort0.00.10.1-0.30.1-0.2-0.2
Run reversals in cocaine runway, females0.60.61.1-0.50.9-1.0-0.4
Run reversals in cocaine runway, males0.50.51.20.00.9-0.0-1.1
Latency to leave start box in cocaine runway0.60.71.9-0.10.7-1.40.4
Latency to leave start box in cocaine runway, F0.20.20.60.3-0.2-0.30.8
Latency to leave start box in cocaine runway, M0.70.71.6-0.11.1-1.3-0.0
Cd content in liver1.21.32.5-1.60.7-0.4-1.4
Co content in liver0.20.30.80.1-0.40.9-0.3
Cu content in liver0.30.40.50.7-0.60.50.6
Fe content in liver0.00.00.0-0.20.0-0.1-0.1
K content in liver0.30.30.70.8-0.40.50.5
Mg content in liver0.50.51.51.2-0.20.30.7
Mn content in liver0.30.40.80.7-0.50.90.2
Na content in liver2.62.74.42.1-1.30.92.0
Rb content in liver0.60.71.5-0.31.2-0.9-0.6
Se content in liver0.10.10.2-0.20.4-0.4-0.3
Sr content in liver3.22.94.8-1.02.1-1.1-2.2
Zn content in liver0.60.61.51.0-0.11.2-0.2