Hub : Genes

Rnd1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression ENSRNOG00000059857 0.21 0.13 3.3e-07 0.1 0.11 0.11 0.11 6.1e-06 1.9e-06 1.3e-06 1.5e-06
2 Brain gene expression ENSRNOG00000059857 0.08 0.05 5.3e-10 0.1 0.1 0.1 0.1 8.8e-10 6.1e-10 8.4e-10 7.2e-10
3 LHb gene expression ENSRNOG00000059857 0.11 0.08 5.5e-03 0.04 0.06 0.01 0.04 3.4e-02 2.0e-02 2.0e-01 4.4e-02
4 Liver gene expression ENSRNOG00000059857 0.03 0.02 2.3e-04 0.02 0.03 0.02 0.02 1.5e-03 4.3e-04 8.8e-04 9.7e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail4.113.416.62.84.13.73.9
BMI without tail0.00.10.3-0.60.20.10.1
Body weight5.824.628.53.85.35.25.3
Epididymis fat weight0.20.50.70.90.70.60.6
Glucose0.10.10.2-0.30.30.40.4
Heart weight0.10.10.20.40.30.10.2
Left kidney weight0.41.31.91.21.40.81.0
Right kidney weight2.57.28.12.22.82.82.8
Tail length0.10.20.3-0.6-0.5-0.4-0.4
Length with tail1.96.87.42.32.72.72.7
Length without tail7.316.018.33.64.34.04.1
Liver weight, left1.72.83.31.21.81.81.8
Liver weight, right1.42.32.81.11.61.71.7
Parametrial fat weight1.93.64.3-1.7-1.9-2.1-2.0
Retroperitoneal fat weight0.41.21.6-1.1-0.8-1.3-1.1
Intraocular pressure7.210.111.5-2.7-3.4-3.2-3.3
Extensor digitorum longus weight3.614.618.32.34.14.34.3
Soleus weight0.51.52.00.91.21.41.4
Tibialis anterior weight0.93.04.60.01.82.12.1
Tibia length6.919.522.03.64.64.74.7
Number of licking bursts0.50.61.6-1.2-0.8-0.3-0.4
Food consumed during 24 hour testing period1.92.33.11.81.61.21.4
Times rat made contact with spout0.10.10.1-0.3-0.0-0.3-0.2
Mean time between licks in bursts0.10.10.20.2-0.4-0.4-0.4
Mean num. licks in bursts0.20.20.70.80.4-0.3-0.1
Std. dev. time between licks in bursts1.01.21.4-1.1-1.2-1.0-1.0
Water consumed over 24 hours0.10.10.30.50.10.00.0
Indifference point 0 sec2.13.33.5-1.7-1.9-1.9-1.9
Indifference point AUC0.20.30.4-0.6-0.6-0.4-0.5
Indifference point function ln k3.65.15.32.12.32.32.3
Indifference point function log k3.65.15.32.12.32.32.3
Delay discounting total patch changes 0 sec2.03.33.4-1.7-1.9-1.8-1.8
Delay discounting total patch changes 12 sec2.02.73.4-1.8-1.7-1.5-1.5
Delay discounting total patch changes 18 sec4.05.26.3-2.1-2.5-2.2-2.3
Delay discounting total patch changes 24 sec2.02.53.0-1.7-1.7-1.4-1.5
Delay discounting total patch changes 6 sec2.33.53.7-1.7-1.9-1.9-1.9
Delay discounting time to switch 0 sec2.23.43.8-1.6-2.0-1.9-1.9
Delay discounting water rate 0 sec2.84.45.21.52.22.32.3
Delay discounting water rate 12 sec3.65.46.02.12.32.42.4
Delay discounting water rate 18 sec0.30.30.50.20.60.70.7
Delay discounting water rate 24 sec2.93.94.91.61.92.22.1
Delay discounting water rate 6 sec3.65.25.91.92.32.42.4
Locomotor activity1.01.61.8-1.3-1.4-1.2-1.2
Locomotor testing distance2.74.55.2-2.0-2.3-2.1-2.1
Locomotor testing rearing2.33.74.4-2.0-2.1-1.7-1.8
Light reinforcement 12.85.06.5-2.1-2.5-2.0-2.2
Light reinforcement 20.81.11.2-1.1-1.1-1.0-1.0
Reaction time number correct1.62.24.02.01.31.31.3
Reaction time mean minus median7.69.912.3-2.5-3.1-3.5-3.4
Reaction time mean minus median AUC5.57.08.8-2.0-2.6-3.0-2.9
Reaction time num false alarms1.52.12.7-0.8-1.5-1.6-1.6
Reaction time num false alarms AUC2.13.04.1-0.9-1.8-2.0-2.0
Reaction time trials correct on left1.62.24.02.01.31.31.3
Reaction time trials on left1.31.83.51.91.11.11.1
Reaction time mean0.50.70.9-0.7-0.8-0.9-0.9
Reaction time mean AUC0.20.30.5-0.4-0.5-0.7-0.6
Median of all reaction times0.00.00.10.10.20.20.2
Reaction time omissions9.012.214.1-2.8-3.6-3.8-3.7
Reaction time false alarm rate2.53.54.2-1.5-1.8-2.1-2.0
Reaction time premature initiation rate6.48.69.5-3.1-3.0-2.8-2.8
Reaction time premature initiations2.84.14.8-1.9-2.2-2.0-2.0
Std. dev. reaction times5.57.69.4-2.1-2.7-3.1-3.0
Reaction time trials completed1.31.83.51.91.11.11.1
Reaction time trials AUC1.92.84.72.21.41.51.4
Social response proportion0.10.10.2-0.3-0.3-0.4-0.3
Social responses7.49.610.8-2.7-3.3-3.2-3.2
Social time0.00.10.10.30.1-0.3-0.2
Conditioned locomotion0.00.00.10.1-0.10.40.2
Cocaine response after cond. corrected0.10.10.10.20.3-0.3-0.1
Cocaine response after cond. not corrected0.50.61.1-0.4-0.5-1.0-0.9
Cocaine response before conditioning3.64.45.4-1.7-2.3-2.1-2.2
Saline control response0.10.10.30.50.30.30.3
Condit. Reinf. active minus inactive responses0.00.00.1-0.0-0.3-0.1-0.2
Condit. Reinf. active-inactive response ratio0.30.30.4-0.5-0.6-0.6-0.6
Condit. Reinf. active responses0.20.30.4-0.3-0.6-0.5-0.6
Condit. Reinf. inactive responses0.60.81.1-0.7-1.1-0.8-0.9
Condit. Reinf. lever presses0.00.00.00.1-0.1-0.1-0.1
Condit. Reinf. lever reinforcers received0.50.70.9-0.6-1.0-0.9-0.9
Pavlov. Cond. lever latency0.00.00.10.20.10.10.0
Pavlov. Cond. magazine entry latency1.01.21.31.11.11.11.1
Pavlov. Cond. change in total contacts1.31.92.51.01.61.41.5
Pavlov. Cond. index score0.50.60.70.60.80.80.8
Pavlov. Cond. latency score0.50.70.80.70.90.80.9
Pavlov. Cond. lever contacts0.10.10.2-0.4-0.3-0.4-0.3
Pavlov. Cond. magazine entry number2.02.52.9-1.3-1.6-1.7-1.7
Pavlov. Cond. intertrial magazine entries4.76.06.7-2.2-2.5-2.6-2.5
Pavlov. Cond. lever-magazine prob. diff.0.81.01.20.81.11.11.1
Pavlov. Cond. response bias0.00.00.0-0.1-0.0-0.0-0.0
Conditioned reinforcement - actives1.61.51.6-1.2-1.3-1.2-1.2
Conditioned reinforcement - inactives1.71.92.2-1.2-1.3-1.5-1.4
Conditioned locomotion0.40.50.6-0.7-0.8-0.5-0.6
Intermittent access intake day 1-15 change1.21.21.5-1.0-1.0-1.2-1.1
Intermittent access intake escalation0.80.81.1-0.8-0.8-1.0-0.9
Intermittent access intake escalation 21.31.31.6-1.1-1.0-1.3-1.2
Intermitt. access day 1 inactive lever presses3.03.34.5-1.5-2.1-1.7-1.9
Intermitt. access day 15 inactive lever presses1.11.21.7-0.7-1.3-1.1-1.2
Intermitt. access escalation Index0.30.20.3-0.5-0.5-0.4-0.4
Intermittent access day 1 total infusions1.11.21.5-0.9-1.1-1.2-1.2
Intermittent access day 15 total infusions2.42.72.9-1.5-1.6-1.7-1.7
Intermittent access terminal intake (last 3 days)2.52.83.1-1.5-1.7-1.8-1.7
Intermittent access total infusions2.42.62.8-1.5-1.6-1.7-1.7
Intermittent access day 1 locomotion1.01.01.4-1.1-1.2-0.8-1.0
Intermittent access day 15 total locomotion1.61.72.3-1.5-1.5-1.0-1.2
Intermittent access total locomotion3.43.84.9-2.0-2.2-1.7-1.9
Intermittent access standard deviation0.50.50.6-0.7-0.6-0.8-0.7
Cocaine induced anxiety0.91.11.40.71.01.21.2
Post-drug Anxiety4.65.15.62.02.32.42.4
Baseline Anxiety1.01.11.31.01.11.01.1
Lifetime Intake2.22.52.6-1.6-1.5-1.6-1.5
Incentive Sensitization - Responses0.00.00.10.20.10.20.2
Incentive Sensitization - Breakpoint0.00.00.00.1-0.00.10.0
Progressive ratio test 1 active lever presses4.34.54.8-2.2-2.2-2.0-2.1
Progressive ratio test 1 breakpoint4.04.14.5-2.1-2.1-1.9-1.9
Progressive ratio test 1 inactive lever presses3.73.94.3-2.0-2.1-1.9-1.9
Progressive ratio test 2 active lever presses2.22.32.8-1.5-1.7-1.4-1.5
Progressive ratio test 2 breakpoint2.83.13.8-1.7-1.9-1.6-1.7
Progressive ratio test 2 inactive lever presses2.42.83.5-1.3-1.9-1.7-1.7
Total sessions with >9 infusions0.70.81.3-1.2-0.8-0.8-0.8
Short access day 1 total inactive lever presses1.31.41.5-1.2-1.2-1.2-1.2
Short access day 10 total inactive lever presses0.30.40.7-0.5-0.8-0.4-0.6
Short access day 1 total infusions0.00.00.2-0.4-0.0-0.1-0.0
Short access day 10 total infusions0.91.01.5-1.2-0.8-1.0-0.9
Short access total infusions0.40.51.0-1.0-0.6-0.6-0.5
Short access day 1 locomotion0.20.20.6-0.8-0.3-0.1-0.1
Short access day 10 total locomotion0.30.30.6-0.8-0.7-0.2-0.4
Short access total locomotion0.60.61.1-1.1-0.8-0.4-0.5
Compulsive drug intake1.01.01.11.11.10.90.9
One hour access (0.3 mA shock)0.20.30.5-0.7-0.4-0.5-0.5
One hour access (shock baseline)0.10.20.4-0.6-0.3-0.3-0.3
Number of responses in last shaping day0.10.10.2-0.20.10.40.3
Context. condit. distance diff. score0.20.30.40.20.50.60.6
Locomotion velocity, session 11.01.11.4-0.9-1.2-1.0-1.1
Locomotion distance, session 12.53.24.4-1.1-1.8-2.1-2.0
Locomotion velocity, session 20.20.20.40.0-0.5-0.6-0.6
Locomotion distance, session 21.92.83.8-0.9-1.7-2.0-1.9
Locomotion velocity, session 33.43.94.9-1.4-2.0-2.2-2.2
Locomotion distance, session 34.44.85.9-1.5-2.3-2.4-2.4
Stereotopy head waving bouts, day 31.11.31.61.01.11.31.2
Stereotopy head waving duration, day 30.50.60.70.80.70.80.8
Locomotion velocity, session 70.20.20.2-0.4-0.5-0.3-0.4
Locomotion distance, session 71.41.82.1-1.3-1.4-1.3-1.4
Stereotopy head waving bouts, day 70.80.91.40.60.91.21.1
Stereotopy head waving duration, day 71.01.21.80.71.01.31.3
Locomotion velocity, session 80.00.00.0-0.10.10.10.1
Locomotion distance, session 81.01.52.1-0.7-1.2-1.4-1.4
Degree of sensitization distance0.50.50.70.30.70.80.8
Degree of sensitization stereotypy0.20.20.4-0.10.30.60.5
Condit. Reinf. active minus inactive responses0.00.00.10.0-0.1-0.3-0.3
Condit. Reinf. active-inactive response ratio0.30.30.60.80.60.30.4
Condit. Reinf. active responses0.50.60.8-0.6-0.7-0.9-0.8
Condit. Reinf. inactive responses2.73.13.4-1.7-1.8-1.8-1.8
Incentive salience index mean0.00.00.10.10.30.20.2
Condit. Reinf. lever presses0.20.20.40.10.60.50.6
Time in familiar zone, hab. session 10.30.20.4-0.2-0.4-0.7-0.6
Time in novel zone, hab. session 10.20.20.50.00.30.70.6
Total zone transitions, hab. session 10.30.40.5-0.6-0.7-0.6-0.7
Total locomotion distance, hab. session 10.10.10.30.50.1-0.0-0.0
Locomotion velocity, hab. session 10.10.10.30.50.10.10.1
Time in familiar zone, hab. session 20.30.40.60.80.70.40.5
Time in novel zone, hab. session 20.40.40.7-0.9-0.8-0.3-0.4
Total zone transitions, hab. session 20.20.30.5-0.3-0.5-0.7-0.6
Total locomotion distance, hab. session 20.10.10.20.4-0.2-0.4-0.4
Locomotion velocity, hab. session 20.10.10.20.5-0.0-0.3-0.2
Novel to familiar place preference ratio1.41.52.20.71.21.51.4
Novelty place preference1.01.01.60.60.91.31.2
Time in novel zone, NPP test0.80.81.40.50.81.21.1
Total zone transitions, NPP test1.01.52.0-0.9-1.1-1.4-1.3
Total locomotion distance, NPP test1.41.92.6-0.7-1.4-1.6-1.6
Locomotion velocity, NPP test0.71.01.5-0.4-0.9-1.2-1.1
Pavlov. Cond. lever latency0.10.10.30.5-0.00.10.0
Pavlov. Cond. magazine entry latency0.00.00.10.30.2-0.1-0.0
Pavlov. Cond. change in total contacts0.00.10.1-0.10.30.20.3
Pavlov. Cond. index score0.10.10.1-0.20.40.30.3
Pavlov. Cond. latency score0.10.10.1-0.20.30.20.3
Pavlov. Cond. lever contacts0.40.40.9-1.0-0.5-0.6-0.5
Pavlov. Cond. magazine entry number0.00.00.00.1-0.00.10.1
Pavlov. Cond. intertrial magazine entries0.30.30.5-0.4-0.5-0.7-0.7
Pavlov. Cond. lever-magazine prob. diff.0.20.30.50.00.70.50.6
Pavlov. Cond. response bias0.00.00.1-0.2-0.0-0.3-0.2
Bone: apparent density10.417.219.34.14.44.04.1
Bone surface11.820.823.04.34.84.54.6
Bone volume9.015.316.83.84.13.83.9
Bone: connectivity density7.511.713.43.43.73.23.4
Bone: cortical apparent density0.30.40.6-0.6-0.8-0.6-0.6
Bone: cortical area9.214.015.83.04.03.94.0
Bone: cortical porosity0.90.91.4-0.4-1.2-1.0-1.1
Bone: cortical porosity1.31.42.1-0.5-1.4-1.2-1.3
Bone: cortical thickness3.55.87.11.62.72.52.6
Bone: cortical thickness0.20.20.30.00.60.40.5
Bone: cortical tissue density0.40.50.8-0.6-0.9-0.7-0.8
Bone: elastic displacement4.34.85.6-1.8-2.4-2.3-2.3
Bone: elastic work0.00.00.10.3-0.1-0.0-0.1
Bone: endosteal estimation7.215.517.03.63.94.14.1
Bone: endosteal perimeter6.312.914.82.93.73.83.8
Bone: final force9.715.917.93.64.24.04.1
Bone: final moment10.216.818.73.94.34.14.2
Bone: marrow area7.015.116.73.63.94.14.0
Bone: maximum diameter3.56.57.81.82.72.82.8
Bone: maximum force13.523.524.94.55.04.94.9
Bone: maximum moment14.024.425.64.85.14.95.0
Bone: minimum diameter8.415.617.83.34.04.24.2
Bone: periosteal estimation11.323.125.54.15.05.05.0
Bone: periosteal perimeter9.816.218.23.44.34.14.2
Bone: post-yield work7.510.211.72.93.13.43.3
Bone: stiffness16.125.527.14.65.25.25.2
Bone: tissue strength1.01.01.51.20.91.00.9
Bone: trabecular number6.710.513.13.63.42.83.0
Bone: trabecular spacing2.53.24.3-2.1-2.0-1.4-1.6
Bone: trabecular thickness0.10.10.20.0-0.1-0.4-0.3
Bone: trabecular tissue density0.10.10.2-0.3-0.5-0.2-0.3
Breakpoint value in progressive ratio session0.10.20.20.10.40.50.5
Distance traveled before self-admin1.21.31.5-1.2-1.2-1.0-1.1
Distance traveled after self-admin0.10.10.2-0.1-0.4-0.5-0.4
Delta time in closed arm before/after self-admin0.30.30.50.70.70.30.4
Delta time in open arm before/after self-admin4.13.94.6-1.8-2.1-1.9-2.0
Diff in mean of infusions in LGA sessions1.41.62.01.21.41.21.3
Extinction: sum of active levers before priming0.30.30.50.30.50.70.6
Active lever presses in extinction session 60.50.40.60.70.70.60.7
Delta distance traveled before/after self-admin0.20.20.60.80.40.10.2
Delta ambulatory time before/after self-admin0.10.10.20.40.20.00.1
Time in closed arm before self-admin1.21.41.91.01.11.41.3
Time in closed arm after self-admin0.60.70.70.90.80.80.8
Time in open arm before self-admin0.70.70.90.60.90.90.9
Time in open arm after self-admin0.30.30.3-0.6-0.6-0.4-0.5
Sum of active levers in priming session hrs 5-60.10.10.1-0.1-0.2-0.3-0.3
Time to tail flick, vehicle, before self-admin1.01.01.3-0.6-1.0-1.1-1.1
Time to tail flick, vehicle, after self-admin0.20.20.40.20.30.60.5
Time to tail flick, test, before self-admin0.30.30.4-0.4-0.6-0.6-0.6
Time to tail flick, test, after self-admin0.10.20.20.30.40.40.4
Delta time to tail flick, vehicle, before/after SA0.40.40.60.30.60.80.7
Delta time to tail flick, test, before/after SA0.20.10.20.20.40.40.4
Ambulatory time before self-admin4.04.14.8-2.0-2.2-1.9-2.0
Ambulatory time after self-admin1.61.82.2-1.2-1.5-1.3-1.3
Total heroin consumption1.61.92.90.71.31.71.6
Area under the delay curve0.91.01.50.61.21.01.1
Delay disc. indifference point, 0s delay1.11.21.60.81.11.21.2
Delay disc. indifference point, 16s delay0.90.91.20.51.01.11.1
Delay disc. indifference point, 2s delay1.21.41.51.11.21.21.2
Delay disc. indifference point, 24s delay1.31.21.50.81.21.21.2
Delay disc. indifference point, 4s delay0.30.30.60.60.70.40.5
Delay disc. indifference point, 8s delay2.52.63.61.11.91.61.7
Delay discount exponential model param0.80.91.3-0.6-1.2-0.9-1.0
Delay discount hyperbolic model param0.80.91.3-0.7-1.1-0.9-1.0
Fecal boli incidents, locomotor time 11.51.62.7-0.9-0.9-1.6-1.4
Change in fecal boli incidents, locomotor task1.31.21.41.21.01.21.1
Time >=10cm from walls, locomotor time 10.20.20.40.30.60.40.5
Bouts of movement, locomotor time 10.00.00.10.00.30.10.2
Total resting periods, locomotor time 10.10.10.2-0.3-0.2-0.4-0.4
Rest time, locomotor task time 10.20.20.3-0.5-0.4-0.6-0.5
Distance moved, locomotor task time 10.00.00.10.2-0.10.1-0.0
Vertical activity count, locomotor time 11.41.51.81.31.31.11.2
Time >=10cm from walls, locomotor time 20.50.50.5-0.7-0.7-0.7-0.7
Bouts of movement, locomotor time 22.42.63.31.31.51.81.7
Total resting periods, locomotor time 22.72.93.61.41.61.91.8
Rest time, locomotor task time 20.00.10.1-0.00.30.20.3
Distance moved, locomotor task time 20.10.10.20.0-0.4-0.4-0.4
Vertical activity count, locomotor time 20.00.00.00.10.10.20.2
Weight adjusted by age1.92.13.00.81.41.71.7
Seeking ratio, delayed vs. immediate footshock0.40.50.80.80.90.40.6
Locomotion in novel chamber0.50.60.80.50.80.90.9
Locomotion in novel chamber post-restriction0.00.00.10.10.20.30.3
Progressive ratio0.00.00.10.0-0.1-0.3-0.2
Food seeking constrained by brief footshock0.20.30.4-0.7-0.5-0.5-0.5
Seeking ratio, punishment vs. effort0.00.00.1-0.3-0.10.10.0
Run reversals in cocaine runway, females0.00.00.1-0.2-0.2-0.0-0.1
Run reversals in cocaine runway, males1.51.41.6-1.2-1.3-1.2-1.2
Latency to leave start box in cocaine runway0.00.00.0-0.2-0.1-0.1-0.1
Latency to leave start box in cocaine runway, F1.71.92.4-1.2-1.6-1.3-1.4
Latency to leave start box in cocaine runway, M1.91.82.31.11.51.31.4
Cd content in liver0.60.60.8-0.9-0.7-0.7-0.7
Co content in liver0.60.72.0-1.4-0.5-0.5-0.4
Cu content in liver0.70.91.10.41.11.01.1
Fe content in liver0.30.40.9-1.0-0.5-0.5-0.5
K content in liver0.30.30.50.30.70.50.6
Mg content in liver0.00.00.0-0.00.1-0.1-0.0
Mn content in liver0.00.10.10.40.10.30.2
Na content in liver0.10.10.3-0.5-0.2-0.1-0.1
Rb content in liver0.30.41.0-1.0-0.6-0.5-0.5
Se content in liver0.50.60.7-0.7-0.7-0.9-0.8
Sr content in liver0.40.40.50.20.70.70.7
Zn content in liver1.81.92.9-1.7-1.4-1.2-1.2