Trps1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000024998	0.32	0.09	0.0e+00	0.19	0.22	0.25	0.24	1.6e-20	1.2e-24	3.9e-27	9.3e-27
2	BLA	gene expression	ENSRNOG00000024998	0.17	0.11	1.6e-03	0.01	0.05	0.04	0.02	7.2e-02	1.1e-03	5.3e-03	3.3e-02
3	Brain	gene expression	ENSRNOG00000024998	0.06	0.03	1.0e-06	0.05	0.07	0.05	0.06	1.2e-05	8.2e-07	2.1e-05	2.9e-06
4	OFC	isoform ratio	ENSRNOT00000097264	0.15	0.09	8.3e-03	0.03	0.03	0.05	0.02	6.7e-02	8.4e-02	2.8e-02	1.2e-01
5	PL	isoform ratio	ENSRNOT00000050774	0.04	0.02	4.1e-03	0	0.02	0.01	0.01	2.2e-01	1.0e-02	3.9e-02	3.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
BMI with tail	5.5	17.8	33.3	-3.2	3.8	4.6	-3.1	5.8
BMI without tail	4.4	9.3	23.1	-1.8	2.1	3.6	-1.7	4.8
Body weight	5.7	24.2	30.1	-3.8	4.8	5.5	-4.9	5.4
Epididymis fat weight	1.2	2.7	6.8	-1.0	2.0	2.6	-0.9	1.1
Glucose	0.7	1.1	1.8	1.2	1.2	1.4	0.5	0.8
Heart weight	0.4	0.5	0.9	0.9	-0.7	-0.7	0.9	0.0
Left kidney weight	1.4	4.1	10.2	-1.2	2.3	1.9	-3.2	-0.6
Right kidney weight	2.5	7.1	14.6	-1.1	3.3	2.9	-3.8	0.8
Tail length	0.1	0.3	0.8	-0.3	-0.1	0.7	-0.9	0.6
Length with tail	1.1	3.9	8.7	-1.6	2.1	1.8	-2.9	0.9
Length without tail	2.3	5.1	9.2	-3.0	2.6	1.2	-2.7	0.7
Liver weight, left	1.8	2.9	6.0	-0.5	2.0	1.8	-2.5	1.2
Liver weight, right	2.9	4.8	11.7	-2.9	1.2	1.1	-1.0	3.4
Parametrial fat weight	3.2	6.2	8.8	-2.1	2.6	3.0	-2.6	2.1
Retroperitoneal fat weight	1.2	4.0	8.1	-0.6	2.0	2.9	-1.0	2.6
Intraocular pressure	0.2	0.2	0.6	0.7	-0.2	-0.4	0.4	0.5
Extensor digitorum longus weight	2.1	8.4	13.6	-3.5	2.6	1.6	-3.7	2.6
Soleus weight	0.6	1.7	3.7	-1.9	-1.2	-0.8	0.9	1.3
Tibialis anterior weight	0.6	1.9	3.9	-1.4	0.8	-0.1	-1.8	2.0
Tibia length	3.0	8.4	14.0	-3.7	2.6	2.3	-2.7	3.0
Number of licking bursts	0.9	1.1	1.8	-0.7	-1.2	-1.3	0.8	-1.0
Food consumed during 24 hour testing period	0.3	0.4	0.6	-0.7	0.8	0.5	-0.6	-0.5
Times rat made contact with spout	0.8	0.9	1.8	0.8	-0.9	-0.0	1.3	-1.1
Mean time between licks in bursts	0.2	0.2	0.4	0.6	-0.4	-0.2	0.5	0.5
Mean num. licks in bursts	0.5	0.6	2.2	1.5	0.3	0.8	0.1	0.1
Std. dev. time between licks in bursts	0.3	0.4	1.0	-0.6	-0.5	-1.0	0.5	-0.2
Water consumed over 24 hours	0.2	0.3	1.2	0.4	0.2	1.1	0.3	0.0
Indifference point 0 sec	0.8	1.2	2.9	-1.0	0.9	1.2	-0.2	1.7
Indifference point AUC	0.4	0.5	1.8	-1.4	-0.5	-0.1	0.6	0.5
Indifference point function ln k	0.1	0.1	0.3	-0.0	-0.1	-0.1	0.1	0.6
Indifference point function log k	0.1	0.1	0.3	-0.0	-0.1	-0.1	0.1	0.6
Delay discounting total patch changes 0 sec	0.7	1.1	2.4	-1.2	0.8	0.9	-0.3	1.5
Delay discounting total patch changes 12 sec	0.2	0.2	0.6	-0.3	0.2	0.8	0.5	0.1
Delay discounting total patch changes 18 sec	0.7	0.9	2.7	-0.9	0.5	0.9	-0.5	1.6
Delay discounting total patch changes 24 sec	0.2	0.3	0.5	-0.3	-0.5	-0.5	0.3	-0.7
Delay discounting total patch changes 6 sec	0.3	0.5	2.5	-1.6	0.2	0.2	0.3	0.1
Delay discounting time to switch 0 sec	0.8	1.3	4.4	1.4	0.1	-0.1	-0.4	-2.1
Delay discounting water rate 0 sec	0.7	1.2	4.0	-1.3	0.4	0.1	-0.0	2.0
Delay discounting water rate 12 sec	0.2	0.3	0.8	-0.2	0.6	0.4	-0.6	0.9
Delay discounting water rate 18 sec	1.4	1.8	3.0	-1.7	1.6	0.9	-0.9	1.3
Delay discounting water rate 24 sec	0.4	0.5	1.2	-1.1	0.8	0.3	-0.1	0.7
Delay discounting water rate 6 sec	0.9	1.3	4.5	-1.3	0.2	0.0	-0.2	2.1
Locomotor activity	2.0	3.2	7.8	-1.5	1.1	2.0	-0.8	2.8
Locomotor testing distance	0.6	1.1	4.3	-0.3	0.1	0.8	0.5	2.1
Locomotor testing rearing	0.9	1.3	3.0	0.5	0.6	1.7	0.3	1.7
Light reinforcement 1	0.9	1.6	2.8	0.5	-1.7	-1.4	1.3	-1.0
Light reinforcement 2	0.2	0.3	0.5	0.6	-0.4	0.0	0.5	-0.7
Reaction time number correct	0.6	0.8	2.5	-1.6	0.2	0.4	0.0	1.1
Reaction time mean minus median	0.8	1.1	1.8	-0.9	1.0	1.4	-0.4	1.2
Reaction time mean minus median AUC	0.1	0.2	0.5	0.2	0.4	0.7	-0.3	0.2
Reaction time num false alarms	0.1	0.2	0.6	-0.3	-0.8	-0.3	0.3	-0.2
Reaction time num false alarms AUC	0.2	0.3	0.8	-0.7	-0.9	-0.4	0.5	-0.0
Reaction time trials correct on left	0.6	0.8	2.5	-1.6	0.2	0.4	0.0	1.1
Reaction time trials on left	0.7	1.0	3.0	-1.7	0.3	0.5	-0.0	1.3
Reaction time mean	2.2	3.1	6.3	-0.5	1.9	2.5	-0.9	2.0
Reaction time mean AUC	2.4	3.2	6.5	-0.6	2.0	2.5	-1.0	2.0
Median of all reaction times	2.2	3.0	6.4	-0.1	2.0	2.5	-1.0	1.9
Reaction time omissions	1.2	1.6	4.0	-2.0	0.8	0.9	0.5	1.5
Reaction time false alarm rate	0.3	0.5	1.2	0.3	-1.1	-0.7	0.4	-0.6
Reaction time premature initiation rate	0.5	0.6	1.2	-0.2	-1.1	-0.5	1.1	0.7
Reaction time premature initiations	0.5	0.7	1.1	-0.9	-0.9	-0.3	1.1	1.0
Std. dev. reaction times	1.9	2.6	4.0	-1.6	1.5	2.0	-0.3	2.0
Reaction time trials completed	0.7	1.0	3.0	-1.7	0.3	0.5	-0.0	1.3
Reaction time trials AUC	0.7	1.0	2.9	-1.7	0.3	0.5	-0.0	1.4
Social response proportion	0.7	0.7	1.1	-1.0	1.0	0.6	-0.8	0.6
Social responses	2.3	3.0	5.4	-1.5	-2.0	-2.3	1.7	0.4
Social time	0.6	0.8	1.2	-0.9	-1.0	-1.1	1.0	0.3
Conditioned locomotion	0.4	0.5	2.3	-1.5	0.4	-0.1	-0.2	-0.0
Cocaine response after cond. corrected	0.2	0.2	0.4	0.6	0.6	0.3	0.0	0.2
Cocaine response after cond. not corrected	0.1	0.1	0.4	0.6	0.2	-0.1	0.4	0.2
Cocaine response before conditioning	0.6	0.8	1.7	0.1	-1.3	-0.9	1.2	0.3
Saline control response	0.2	0.2	0.8	-0.0	0.6	0.9	-0.1	0.0
Condit. Reinf. active minus inactive responses	2.3	2.8	6.0	-2.4	1.6	1.0	-2.0	1.0
Condit. Reinf. active-inactive response ratio	6.3	6.6	10.7	-2.8	2.9	2.0	-3.3	1.4
Condit. Reinf. active responses	1.1	1.5	5.7	-2.4	0.1	-0.1	-1.2	0.6
Condit. Reinf. inactive responses	1.8	2.2	5.4	0.2	-2.3	-1.8	1.3	-0.9
Condit. Reinf. lever presses	0.4	0.6	1.3	0.2	-1.1	-1.1	0.5	-0.5
Condit. Reinf. lever reinforcers received	0.7	1.0	3.8	-1.9	-0.3	-0.5	-0.9	0.2
Pavlov. Cond. lever latency	0.3	0.5	1.0	0.1	0.8	0.8	0.0	1.0
Pavlov. Cond. magazine entry latency	0.4	0.5	0.9	1.0	0.5	0.9	-0.6	-0.3
Pavlov. Cond. change in total contacts	0.2	0.3	1.4	-0.2	0.1	-0.1	-1.2	0.4
Pavlov. Cond. index score	0.1	0.2	0.4	0.4	-0.1	0.0	-0.5	-0.6
Pavlov. Cond. latency score	0.1	0.2	0.4	0.4	-0.1	-0.0	-0.5	-0.7
Pavlov. Cond. lever contacts	0.8	1.1	1.9	0.2	-1.3	-1.2	0.6	-1.4
Pavlov. Cond. magazine entry number	0.7	0.8	1.4	0.5	-0.9	-1.2	1.2	-0.6
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.6	-0.5	0.4	0.8	-0.2	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.4	0.3	0.1	0.2	-0.6	-0.6
Pavlov. Cond. response bias	0.3	0.4	1.0	-0.1	-1.0	-0.8	0.4	-0.6
Conditioned reinforcement - actives	0.4	0.4	1.0	0.1	0.8	1.0	-0.3	0.4
Conditioned reinforcement - inactives	0.5	0.6	2.1	-0.2	-0.3	0.4	0.7	1.5
Conditioned locomotion	2.0	2.4	5.1	-0.8	1.9	2.3	-1.1	1.3
Intermittent access intake day 1-15 change	0.7	0.7	1.8	-0.5	-1.0	-0.8	1.3	0.2
Intermittent access intake escalation	0.7	0.7	2.0	-0.7	-0.8	-0.5	1.4	0.4
Intermittent access intake escalation 2	0.7	0.7	1.5	-0.3	-0.9	-0.9	1.2	0.6
Intermitt. access day 1 inactive lever presses	0.4	0.5	1.4	-0.5	0.7	0.4	-1.2	-0.0
Intermitt. access day 15 inactive lever presses	1.6	1.7	4.3	-1.0	1.3	1.2	-0.1	2.1
Intermitt. access escalation Index	1.0	0.9	2.1	-1.4	1.3	0.5	-0.9	-0.2
Intermittent access day 1 total infusions	0.6	0.7	2.5	1.6	-0.0	0.9	0.6	0.1
Intermittent access day 15 total infusions	0.3	0.3	0.7	0.1	-0.1	0.6	0.9	0.6
Intermittent access terminal intake (last 3 days)	0.6	0.6	1.8	0.3	-0.5	0.2	1.3	1.0
Intermittent access total infusions	0.5	0.5	0.9	1.0	-0.5	0.5	0.8	0.7
Intermittent access day 1 locomotion	0.4	0.4	1.2	0.2	0.7	1.1	-0.3	0.5
Intermittent access day 15 total locomotion	0.6	0.7	1.2	-0.9	0.7	1.0	0.1	1.1
Intermittent access total locomotion	0.6	0.7	2.4	-0.6	0.2	0.6	0.5	1.6
Intermittent access standard deviation	0.4	0.4	1.7	-0.4	-0.5	-0.3	0.3	1.3
Cocaine induced anxiety	0.2	0.3	0.8	0.9	-0.2	-0.3	-0.2	-0.6
Post-drug Anxiety	0.7	0.8	2.3	1.5	-0.2	-0.3	-0.4	-1.1
Baseline Anxiety	0.0	0.0	0.1	-0.3	0.1	0.0	0.0	0.4
Lifetime Intake	0.5	0.6	0.7	0.9	-0.2	0.8	0.8	0.8
Incentive Sensitization - Responses	0.4	0.4	1.0	-0.2	-0.1	0.8	0.6	1.0
Incentive Sensitization - Breakpoint	0.2	0.2	0.4	-0.1	-0.2	0.5	0.5	0.7
Progressive ratio test 1 active lever presses	1.3	1.4	2.3	-0.1	1.5	1.5	-0.9	1.2
Progressive ratio test 1 breakpoint	1.4	1.4	2.5	0.1	1.5	1.6	-0.9	1.3
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.3	-0.4	0.3	0.6	0.2	0.5
Progressive ratio test 2 active lever presses	1.0	1.0	1.9	-0.7	1.1	1.4	-0.5	1.2
Progressive ratio test 2 breakpoint	0.4	0.5	1.0	-0.3	0.7	1.0	-0.3	0.8
Progressive ratio test 2 inactive lever presses	0.4	0.4	1.3	0.0	-0.1	0.4	0.8	1.1
Total sessions with >9 infusions	1.4	1.5	4.4	-0.2	1.5	2.1	-0.9	0.5
Short access day 1 total inactive lever presses	1.4	1.6	4.7	-0.2	1.1	2.2	-0.3	1.3
Short access day 10 total inactive lever presses	1.7	1.9	3.6	-0.9	1.3	1.9	-1.4	1.1
Short access day 1 total infusions	0.9	0.9	2.3	-0.1	0.5	1.5	0.5	1.3
Short access day 10 total infusions	0.1	0.1	0.5	0.7	-0.0	0.2	0.3	0.1
Short access total infusions	0.5	0.6	1.2	0.6	0.0	1.1	0.8	0.8
Short access day 1 locomotion	1.2	1.2	2.4	-0.9	1.2	1.5	-0.8	1.0
Short access day 10 total locomotion	0.5	0.5	1.7	-1.3	0.6	0.7	-0.4	0.1
Short access total locomotion	1.2	1.3	2.6	-1.0	1.1	1.6	-0.6	1.1
Compulsive drug intake	0.1	0.1	0.4	0.2	0.3	0.1	-0.7	0.0
One hour access (0.3 mA shock)	0.6	0.7	2.5	-0.2	0.3	0.8	-0.2	1.6
One hour access (shock baseline)	0.7	0.8	2.4	0.2	0.0	1.0	0.6	1.6
Number of responses in last shaping day	0.2	0.2	0.5	-0.7	0.6	0.0	-0.1	-0.1
Context. condit. distance diff. score	0.5	0.6	2.1	-0.0	-0.7	0.2	0.6	1.4
Locomotion velocity, session 1	0.4	0.4	1.1	-1.0	-0.4	-0.9	0.2	-0.5
Locomotion distance, session 1	1.8	2.3	4.3	-1.9	-1.5	-2.1	0.7	-0.9
Locomotion velocity, session 2	2.4	2.8	8.2	1.1	-1.0	-2.0	0.1	-2.9
Locomotion distance, session 2	2.3	3.3	7.5	-0.4	-2.0	-2.7	1.4	-1.7
Locomotion velocity, session 3	0.8	1.0	4.4	-2.1	0.1	0.2	-0.5	0.4
Locomotion distance, session 3	0.2	0.2	0.6	-0.3	-0.8	-0.0	0.6	-0.1
Stereotopy head waving bouts, day 3	0.3	0.4	0.6	-0.8	-0.7	-0.6	0.6	0.5
Stereotopy head waving duration, day 3	0.7	0.9	2.6	-1.0	-0.8	-1.6	-0.3	-0.2
Locomotion velocity, session 7	0.2	0.2	0.6	-0.5	0.3	0.1	-0.8	0.2
Locomotion distance, session 7	0.1	0.2	0.7	-0.9	0.1	-0.0	-0.3	-0.1
Stereotopy head waving bouts, day 7	2.3	2.6	6.0	0.4	-2.1	-2.5	1.4	-0.9
Stereotopy head waving duration, day 7	1.4	1.7	4.3	0.1	-1.5	-2.1	0.8	-1.1
Locomotion velocity, session 8	0.5	0.6	1.7	-1.3	-0.3	-1.0	-0.3	-0.6
Locomotion distance, session 8	1.3	2.0	3.8	-1.1	-1.9	-1.7	1.3	-0.3
Degree of sensitization distance	0.9	0.9	1.6	-1.2	1.2	0.5	-0.9	0.7
Degree of sensitization stereotypy	2.4	2.6	5.1	0.8	-1.9	-2.3	0.9	-1.7
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	-0.4	0.2	0.2	0.5	0.4
Condit. Reinf. active-inactive response ratio	1.2	1.3	4.2	2.1	-0.5	-0.1	1.4	-0.1
Condit. Reinf. active responses	0.4	0.5	2.4	-1.5	0.1	-0.1	0.2	0.4
Condit. Reinf. inactive responses	1.7	2.0	9.5	-3.1	0.2	-0.4	-0.6	0.2
Incentive salience index mean	0.1	0.1	0.3	-0.5	-0.0	0.3	0.3	0.4
Condit. Reinf. lever presses	0.1	0.1	0.4	-0.0	-0.6	-0.2	0.2	-0.3
Time in familiar zone, hab. session 1	0.7	0.7	1.3	0.2	-0.9	-1.1	0.1	-1.1
Time in novel zone, hab. session 1	0.8	0.8	2.0	0.2	0.8	1.1	0.1	1.4
Total zone transitions, hab. session 1	2.0	2.8	7.7	-1.6	-1.8	-2.8	0.7	0.1
Total locomotion distance, hab. session 1	1.8	2.5	6.6	-2.6	-0.9	-1.3	0.8	1.7
Locomotion velocity, hab. session 1	1.5	2.2	5.2	-2.3	-1.2	-1.6	0.9	1.1
Time in familiar zone, hab. session 2	1.6	1.6	3.8	0.6	-1.2	-1.5	0.6	-1.9
Time in novel zone, hab. session 2	1.9	1.9	5.9	-1.0	1.0	1.1	-0.5	2.4
Total zone transitions, hab. session 2	2.5	3.2	5.7	-2.0	-1.8	-2.4	0.7	-1.7
Total locomotion distance, hab. session 2	1.1	1.4	3.9	-2.0	-0.9	-1.4	0.6	-0.3
Locomotion velocity, hab. session 2	0.9	1.2	2.5	-1.6	-0.9	-1.4	0.7	-0.6
Novel to familiar place preference ratio	0.4	0.4	1.2	-0.3	0.4	0.5	0.6	1.1
Novelty place preference	0.4	0.4	1.1	-0.2	0.6	0.6	0.5	1.0
Time in novel zone, NPP test	0.4	0.5	1.4	-0.2	0.6	0.5	0.4	1.2
Total zone transitions, NPP test	1.8	2.6	5.8	-2.4	-1.7	-2.0	0.8	-0.1
Total locomotion distance, NPP test	1.1	1.6	6.5	-2.6	-0.4	-0.9	-0.1	0.7
Locomotion velocity, NPP test	1.2	1.8	7.1	-2.7	-0.6	-0.9	0.2	0.7
Pavlov. Cond. lever latency	0.1	0.2	0.5	0.3	0.4	0.3	-0.1	0.7
Pavlov. Cond. magazine entry latency	0.4	0.5	2.3	1.5	-0.2	0.1	0.3	-0.3
Pavlov. Cond. change in total contacts	0.9	0.9	1.5	0.1	-1.2	-1.1	1.2	-0.8
Pavlov. Cond. index score	0.2	0.2	0.4	0.4	-0.6	-0.4	0.5	-0.6
Pavlov. Cond. latency score	0.3	0.4	0.6	-0.0	-0.8	-0.6	0.6	-0.8
Pavlov. Cond. lever contacts	0.3	0.4	0.8	-0.9	-0.8	-0.5	0.5	-0.4
Pavlov. Cond. magazine entry number	0.6	0.7	2.8	-1.7	0.3	-0.2	-0.7	-0.1
Pavlov. Cond. intertrial magazine entries	1.6	1.9	6.0	-2.5	1.1	0.7	-1.0	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.1	0.1	-0.4	-0.0	0.3	-0.4
Pavlov. Cond. response bias	0.3	0.4	0.8	0.9	-0.7	-0.0	0.8	0.1
Bone: apparent density	0.6	0.9	1.4	1.2	0.7	1.2	-1.0	0.3
Bone surface	0.5	0.9	1.8	0.8	0.9	1.1	-1.3	0.2
Bone volume	0.5	0.8	1.4	1.2	0.6	0.7	-1.2	-0.5
Bone: connectivity density	1.1	1.6	2.9	1.6	1.3	1.7	-1.0	0.3
Bone: cortical apparent density	2.4	3.1	4.9	0.7	-2.2	-2.0	1.6	-1.8
Bone: cortical area	0.7	1.0	3.0	-1.7	-0.3	-0.3	-0.4	1.3
Bone: cortical porosity	1.0	1.0	4.0	0.2	0.3	1.0	-0.0	2.0
Bone: cortical porosity	1.3	1.4	5.2	-0.5	0.6	1.2	-0.1	2.3
Bone: cortical thickness	0.5	0.9	1.5	-0.5	-1.2	-0.8	0.9	1.1
Bone: cortical thickness	0.3	0.4	0.8	-0.5	0.5	0.4	-0.8	0.9
Bone: cortical tissue density	2.4	3.1	4.7	0.8	-2.2	-2.0	1.5	-1.9
Bone: elastic displacement	1.4	1.6	4.3	1.1	-1.4	-2.1	0.6	-0.5
Bone: elastic work	0.8	1.0	1.9	-0.2	-1.4	-1.4	0.7	0.9
Bone: endosteal estimation	1.6	3.4	9.2	-1.5	1.8	1.2	-3.0	-0.5
Bone: endosteal perimeter	0.3	0.6	1.7	-1.3	0.1	0.2	-0.8	0.6
Bone: final force	1.3	2.1	4.0	-1.7	0.9	1.3	-1.1	2.0
Bone: final moment	0.8	1.3	2.7	-1.4	0.6	0.9	-1.0	1.6
Bone: marrow area	1.5	3.3	8.9	-1.5	1.9	1.3	-3.0	-0.4
Bone: maximum diameter	1.2	2.1	5.0	-2.2	1.0	0.9	-1.6	1.1
Bone: maximum force	1.7	2.9	6.0	-2.5	0.9	1.2	-1.5	2.0
Bone: maximum moment	1.2	2.1	4.8	-2.2	0.6	0.7	-1.4	1.7
Bone: minimum diameter	1.4	2.6	7.2	-2.7	0.4	0.7	-1.1	2.0
Bone: periosteal estimation	0.8	1.7	4.0	-1.9	0.8	0.6	-2.0	0.4
Bone: periosteal perimeter	0.4	0.7	3.1	-1.8	-0.4	-0.4	-0.2	0.4
Bone: post-yield work	1.6	2.2	6.0	-2.4	1.2	0.9	-1.7	0.2
Bone: stiffness	0.8	1.3	2.6	-1.5	0.5	1.1	-0.5	1.6
Bone: tissue strength	0.0	0.0	0.1	0.3	0.1	-0.1	0.1	0.2
Bone: trabecular number	0.5	0.8	2.3	1.5	0.6	0.9	-0.9	0.0
Bone: trabecular spacing	0.3	0.4	1.0	0.7	1.0	0.5	-0.5	-0.2
Bone: trabecular thickness	0.1	0.2	0.3	0.1	-0.6	-0.5	-0.1	-0.3
Bone: trabecular tissue density	1.4	1.9	6.5	0.1	-1.6	-0.7	2.5	0.5
Breakpoint value in progressive ratio session	0.7	0.8	1.9	0.3	1.1	1.4	-0.7	0.1
Distance traveled before self-admin	0.6	0.7	1.7	-1.3	-0.3	0.2	0.8	1.0
Distance traveled after self-admin	0.1	0.1	0.4	0.6	-0.3	0.2	-0.4	-0.1
Delta time in closed arm before/after self-admin	0.8	0.7	1.3	0.7	-1.1	-1.1	-0.2	-0.8
Delta time in open arm before/after self-admin	1.0	1.0	1.9	-0.5	1.4	1.0	-1.1	0.7
Diff in mean of infusions in LGA sessions	0.5	0.6	1.7	0.3	1.3	0.4	-1.1	-0.1
Extinction: sum of active levers before priming	0.3	0.3	0.8	0.0	0.3	0.2	-0.8	-0.9
Active lever presses in extinction session 6	0.6	0.6	1.3	0.6	-1.2	-0.5	1.0	-0.2
Delta distance traveled before/after self-admin	0.6	0.7	1.8	1.0	0.5	0.3	-1.3	-0.4
Delta ambulatory time before/after self-admin	0.5	0.5	1.2	0.8	0.3	0.1	-1.1	-0.8
Time in closed arm before self-admin	1.0	1.1	1.9	-0.8	1.3	1.4	-1.2	0.4
Time in closed arm after self-admin	0.4	0.4	1.5	0.2	-0.3	-0.5	-0.3	-1.2
Time in open arm before self-admin	0.2	0.2	0.4	-0.2	-0.6	-0.7	0.3	0.2
Time in open arm after self-admin	0.6	0.7	1.2	-1.1	0.9	0.3	-0.9	0.6
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.7	0.3	0.0	-0.1	-0.6	0.8
Time to tail flick, vehicle, before self-admin	6.0	6.1	17.6	-0.4	3.0	1.4	-4.2	-1.3
Time to tail flick, vehicle, after self-admin	1.5	1.6	3.6	-1.9	0.8	1.2	0.7	1.3
Time to tail flick, test, before self-admin	0.4	0.4	1.0	-0.6	0.6	1.0	-0.4	0.3
Time to tail flick, test, after self-admin	0.7	0.8	2.3	0.8	-0.6	0.4	1.5	0.5
Delta time to tail flick, vehicle, before/after SA	5.9	5.8	19.1	-0.7	-2.5	-0.9	4.4	1.5
Delta time to tail flick, test, before/after SA	1.3	1.2	3.3	0.3	-0.7	-0.2	1.8	1.3
Ambulatory time before self-admin	0.7	0.8	1.7	-1.3	-0.2	0.5	0.7	1.2
Ambulatory time after self-admin	0.1	0.2	0.5	0.7	-0.2	0.3	-0.3	0.3
Total heroin consumption	0.5	0.6	0.8	-0.9	0.9	0.9	-0.8	-0.3
Area under the delay curve	2.1	2.2	4.3	0.9	-2.1	-1.5	2.0	-0.0
Delay disc. indifference point, 0s delay	0.1	0.1	0.4	-0.6	-0.0	0.0	0.0	0.4
Delay disc. indifference point, 16s delay	1.5	1.5	2.8	0.5	-1.7	-1.7	1.2	-0.5
Delay disc. indifference point, 2s delay	2.4	2.7	5.3	1.2	-2.0	-1.5	2.3	-0.3
Delay disc. indifference point, 24s delay	1.9	1.8	3.5	0.4	-1.6	-1.9	1.6	-0.6
Delay disc. indifference point, 4s delay	1.2	1.2	2.7	0.5	-1.6	-1.2	1.3	0.3
Delay disc. indifference point, 8s delay	1.6	1.7	4.7	0.4	-1.6	-0.3	2.2	1.0
Delay discount exponential model param	2.5	2.7	5.0	-1.2	2.2	1.6	-2.1	0.2
Delay discount hyperbolic model param	2.5	2.7	5.0	-1.2	2.2	1.6	-2.1	0.2
Fecal boli incidents, locomotor time 1	0.6	0.6	1.7	0.3	-0.9	-1.3	0.8	-0.2
Change in fecal boli incidents, locomotor task	0.9	0.8	1.7	-0.5	1.3	0.9	-1.2	0.1
Time >=10cm from walls, locomotor time 1	1.3	1.3	3.1	-1.4	0.8	0.7	-0.7	1.8
Bouts of movement, locomotor time 1	0.4	0.4	0.9	1.0	0.4	0.5	-0.2	0.9
Total resting periods, locomotor time 1	0.2	0.2	0.6	0.8	0.3	0.1	-0.1	0.7
Rest time, locomotor task time 1	0.6	0.6	1.7	1.3	-0.2	0.3	1.1	0.3
Distance moved, locomotor task time 1	0.4	0.4	0.7	-0.6	-0.4	-0.8	-0.9	-0.5
Vertical activity count, locomotor time 1	0.5	0.5	0.8	-0.7	-0.8	-0.9	0.7	-0.2
Time >=10cm from walls, locomotor time 2	3.3	3.5	5.6	-1.1	1.9	2.4	-1.2	2.3
Bouts of movement, locomotor time 2	0.7	0.7	1.3	0.6	-1.1	-0.9	1.1	0.5
Total resting periods, locomotor time 2	0.8	0.9	1.6	0.7	-1.3	-1.1	1.1	0.1
Rest time, locomotor task time 2	1.9	2.2	4.1	1.4	-1.2	-1.6	0.9	-2.0
Distance moved, locomotor task time 2	0.6	0.7	2.3	-0.4	0.3	0.8	-0.6	1.5
Vertical activity count, locomotor time 2	2.0	2.2	3.9	-1.5	1.1	1.7	-0.8	2.0
Weight adjusted by age	0.6	0.7	1.2	-0.8	0.9	0.2	-0.9	1.1
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.4	0.5	0.4	0.5	-0.6	0.0
Locomotion in novel chamber	0.2	0.3	0.7	-0.0	0.4	0.7	-0.3	0.8
Locomotion in novel chamber post-restriction	0.9	1.1	3.0	1.1	-1.0	0.3	1.7	-0.3
Progressive ratio	2.0	2.3	4.3	0.7	-2.1	-2.0	1.5	-0.8
Food seeking constrained by brief footshock	0.3	0.4	1.4	-1.2	0.7	0.2	-0.2	0.4
Seeking ratio, punishment vs. effort	2.6	3.1	5.2	-1.4	2.3	2.1	-1.4	1.5
Run reversals in cocaine runway, females	1.0	1.0	2.2	1.5	-0.8	-0.2	1.0	-1.1
Run reversals in cocaine runway, males	0.9	0.8	1.7	-0.5	1.3	0.9	-1.2	0.2
Latency to leave start box in cocaine runway	1.8	2.0	4.0	1.3	-1.2	-1.5	0.7	-2.0
Latency to leave start box in cocaine runway, F	2.2	2.4	6.8	1.2	-1.0	-1.7	0.2	-2.6
Latency to leave start box in cocaine runway, M	1.0	1.0	2.1	0.3	-1.3	-1.0	1.5	0.0
Cd content in liver	3.1	3.4	7.5	0.2	-1.8	-2.7	0.8	-2.3
Co content in liver	1.8	2.1	4.9	-0.7	-1.9	-2.2	1.2	-0.6
Cu content in liver	0.7	0.9	2.0	0.8	1.3	1.4	-0.4	0.1
Fe content in liver	0.7	0.8	1.6	-1.3	0.7	0.2	-0.6	-1.2
K content in liver	4.3	4.3	8.2	-2.9	2.0	2.3	-1.3	1.4
Mg content in liver	0.6	0.6	1.7	0.3	0.9	1.3	0.1	0.5
Mn content in liver	0.8	0.9	1.7	-1.0	1.1	1.3	-0.5	0.6
Na content in liver	3.1	3.3	8.9	-0.4	2.3	3.0	-1.4	0.4
Rb content in liver	0.9	1.1	1.7	0.7	1.3	1.3	-1.3	-0.3
Se content in liver	0.4	0.5	1.2	1.1	-0.4	0.3	0.9	0.5
Sr content in liver	1.3	1.2	4.0	-0.8	0.5	1.0	-2.0	0.0
Zn content in liver	0.0	0.0	0.1	0.1	-0.1	-0.1	0.4	-0.0