| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | gene expression | ENSRNOG00000004367 | 0.110 | 0.0540 | 4.2e-10 | 0.047 | 0.051 | 0.047 | 0.044 | 5.8e-06 | 2.5e-06 | 5.1e-06 | 1.1e-05 |
| 2 | Brain | gene expression | ENSRNOG00000004367 | 0.044 | 0.0300 | 9.8e-03 | 0.032 | 0.005 | 0.022 | 0.008 | 5.1e-04 | 9.8e-02 | 3.9e-03 | 5.8e-02 |
| 3 | Eye | isoform ratio | ENSRNOT00000005911 | 0.359 | 0.1590 | 6.5e-03 | 0.013 | 0.103 | -0.002 | 0.044 | 2.0e-01 | 1.2e-02 | 3.4e-01 | 7.3e-02 |
| 4 | NAcc | gene expression | ENSRNOG00000004367 | 0.038 | 0.0240 | 4.5e-03 | 0.001 | 0.018 | -0.002 | 0.004 | 2.6e-01 | 1.6e-02 | 4.7e-01 | 1.4e-01 |
| 5 | PL | gene expression | ENSRNOG00000004367 | 0.211 | 0.0841 | 5.6e-07 | 0.049 | 0.072 | 0.053 | 0.054 | 1.2e-04 | 4.0e-06 | 7.1e-05 | 5.9e-05 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 |
|---|---|---|---|---|---|---|---|---|
| Length with tail | 11.9 | 43.8 | 77.6 | 7.5 | 4.4 | -8.8 | 8.1 | -0.8 |
| Body weight | 8.9 | 37.5 | 68.5 | 7.7 | 2.4 | -8.3 | 6.8 | -2.8 |
| Tail length | 8.9 | 27.0 | 44.2 | 6.1 | 3.8 | -6.7 | 6.2 | -0.5 |
| Tibia length | 6.0 | 16.9 | 31.4 | 5.3 | 0.6 | -5.6 | 4.4 | -2.2 |
| Length without tail | 5.7 | 12.5 | 24.4 | 3.9 | 1.9 | -4.9 | 4.3 | -0.5 |
| Condit. Reinf. active responses | 4.9 | 6.0 | 9.1 | -2.7 | -2.2 | 2.7 | -3.0 | -1.3 |
| Locomotion velocity, hab. session 1 | 4.3 | 6.2 | 20.5 | 1.3 | -2.8 | -0.6 | -0.9 | -4.5 |
| Delay discounting water rate 6 sec | 4.2 | 6.1 | 9.5 | 3.0 | -1.1 | -3.1 | 1.9 | -2.7 |
| Incentive salience index mean | 4.0 | 4.9 | 8.4 | -1.5 | -2.9 | 1.5 | -2.3 | -2.5 |
| BMI without tail | 3.9 | 8.1 | 14.1 | 3.8 | 0.8 | -3.7 | 2.8 | -2.1 |
| Intermitt. access day 1 inactive lever presses | 3.9 | 4.2 | 11.0 | -3.3 | 0.8 | 1.9 | -1.5 | 1.8 |
| Latency to leave start box in cocaine runway, M | 3.7 | 3.5 | 6.0 | 2.4 | 1.1 | -2.4 | 2.1 | -0.5 |
| Condit. Reinf. active minus inactive responses | 3.5 | 3.9 | 5.9 | -1.6 | -2.2 | 2.1 | -2.4 | -1.4 |
| Locomotor activity | 3.4 | 5.4 | 9.8 | 3.1 | 0.9 | -3.0 | 2.3 | -1.5 |
| Social response proportion | 3.4 | 3.7 | 5.2 | 2.3 | -1.3 | -2.3 | 1.0 | -2.3 |
| Left kidney weight | 3.2 | 9.1 | 14.9 | 3.8 | 1.7 | -3.9 | 3.5 | -1.0 |
| One hour access (0.3 mA shock) | 3.2 | 3.7 | 9.0 | -0.1 | -3.0 | -0.1 | -1.0 | -2.9 |
| Condit. Reinf. active-inactive response ratio | 3.1 | 3.3 | 5.8 | -1.5 | -1.9 | 2.1 | -2.4 | -0.8 |
| Total locomotion distance, hab. session 1 | 3.1 | 4.4 | 14.3 | 1.3 | -2.3 | -0.6 | -0.7 | -3.8 |
| Locomotion velocity, hab. session 2 | 3.1 | 4.2 | 8.8 | 0.1 | -2.8 | 0.9 | -1.9 | -3.0 |
| Pavlov. Cond. change in total contacts | 3.1 | 3.3 | 7.0 | -1.3 | -2.7 | 1.5 | -2.1 | -1.1 |
| Total locomotion distance, hab. session 2 | 3.0 | 3.9 | 7.9 | 0.0 | -2.7 | 0.9 | -1.9 | -2.8 |
| Right kidney weight | 2.7 | 7.8 | 12.7 | 3.4 | 1.9 | -3.6 | 3.4 | -0.3 |
| Short access total infusions | 2.4 | 2.7 | 6.9 | 0.8 | -2.2 | -1.0 | -0.1 | -2.6 |
| Total zone transitions, hab. session 1 | 2.4 | 3.4 | 10.5 | 1.6 | -1.7 | -1.0 | -0.2 | -3.2 |
| Social responses | 2.3 | 2.9 | 6.0 | 2.2 | -0.9 | -1.7 | 0.5 | -2.4 |
| Locomotion distance, session 8 | 2.3 | 3.4 | 5.6 | 1.9 | -1.1 | -2.2 | 1.4 | -2.4 |
| Bone: minimum diameter | 2.3 | 4.3 | 10.1 | 3.2 | 0.1 | -2.4 | 1.8 | -1.5 |
| Epididymis fat weight | 2.2 | 5.1 | 8.9 | 2.7 | 0.9 | -3.0 | 2.9 | -0.3 |
| Intermittent access total infusions | 2.2 | 2.5 | 5.9 | -0.8 | -2.3 | -0.2 | -0.8 | -2.4 |
| Condit. Reinf. lever presses | 2.2 | 3.0 | 7.0 | -0.4 | -2.6 | 0.2 | -1.1 | -2.6 |
| Short access day 1 total infusions | 2.1 | 2.2 | 5.4 | 0.4 | -2.2 | -0.2 | -0.6 | -2.3 |
| Delta time to tail flick, vehicle, before/after SA | 2.1 | 2.1 | 4.5 | -2.1 | -1.2 | 1.3 | -1.7 | -0.2 |
| Delay discounting water rate 24 sec | 2.0 | 2.7 | 4.2 | 1.9 | -0.7 | -2.1 | 1.3 | -1.9 |
| Lifetime Intake | 2.0 | 2.3 | 5.8 | -0.2 | -2.2 | -0.4 | -0.6 | -2.4 |
| Progressive ratio test 2 active lever presses | 2.0 | 2.1 | 5.0 | -0.4 | -2.2 | -0.3 | -0.7 | -2.2 |
| Pavlov. Cond. latency score | 2.0 | 2.5 | 5.7 | -1.1 | -2.4 | 1.0 | -1.6 | -1.5 |
| Retroperitoneal fat weight | 1.9 | 6.3 | 11.6 | 3.2 | 0.4 | -3.4 | 2.6 | -1.6 |
| Intraocular pressure | 1.9 | 2.7 | 6.7 | -2.6 | -0.4 | 2.0 | -1.2 | 1.2 |
| Delay discounting total patch changes 12 sec | 1.9 | 2.5 | 4.0 | 1.5 | 2.0 | -1.4 | 1.9 | 0.9 |
| Liver weight, right | 1.8 | 2.9 | 7.1 | 2.7 | -0.3 | -1.9 | 1.6 | -1.1 |
| Reaction time omissions | 1.8 | 2.4 | 5.8 | -1.5 | 0.1 | 2.4 | -1.8 | 0.8 |
| Intermittent access terminal intake (last 3 days) | 1.8 | 2.0 | 5.6 | -0.2 | -2.0 | -0.3 | -0.6 | -2.4 |
| Intermittent access standard deviation | 1.8 | 2.0 | 5.1 | -0.6 | -2.3 | 0.1 | -0.8 | -1.9 |
| Progressive ratio test 2 breakpoint | 1.8 | 2.0 | 4.7 | -0.3 | -2.1 | -0.3 | -0.7 | -2.2 |
| Stereotopy head waving bouts, day 3 | 1.8 | 2.2 | 4.0 | -1.4 | -1.2 | 1.9 | -2.0 | -0.4 |
| Bone: cortical apparent density | 1.8 | 2.4 | 4.5 | 2.1 | 1.0 | -1.7 | 1.9 | 0.4 |
| Bone: cortical tissue density | 1.8 | 2.4 | 4.3 | 2.1 | 1.0 | -1.7 | 1.9 | 0.4 |
| Diff in mean of infusions in LGA sessions | 1.8 | 2.1 | 3.6 | -1.9 | -0.2 | 1.8 | -1.8 | 0.4 |
| Extinction: sum of active levers before priming | 1.8 | 1.8 | 3.4 | -1.8 | -1.0 | 1.4 | -1.5 | -0.7 |
| Vertical activity count, locomotor time 2 | 1.8 | 2.0 | 5.3 | 1.4 | -0.0 | -2.3 | 1.4 | -0.8 |
| Cd content in liver | 1.8 | 1.9 | 3.5 | 1.9 | -1.2 | -1.3 | 0.4 | -1.7 |
| Times rat made contact with spout | 1.7 | 1.9 | 3.8 | -0.8 | -2.0 | 0.4 | -1.3 | -1.8 |
| Pavlov. Cond. intertrial magazine entries | 1.7 | 2.2 | 4.4 | 1.7 | 2.1 | -0.8 | 1.4 | 1.1 |
| Pavlov. Cond. index score | 1.7 | 2.2 | 5.4 | -0.9 | -2.3 | 0.9 | -1.5 | -1.4 |
| Pavlov. Cond. lever-magazine prob. diff. | 1.7 | 2.1 | 5.4 | -0.7 | -2.3 | 0.7 | -1.4 | -1.5 |
| Pavlov. Cond. response bias | 1.7 | 2.1 | 5.3 | -0.5 | -2.3 | 0.8 | -1.4 | -1.5 |
| BMI with tail | 1.6 | 5.0 | 8.6 | 2.9 | -0.9 | -2.6 | 1.5 | -2.6 |
| Progressive ratio test 2 inactive lever presses | 1.6 | 1.8 | 2.6 | -1.6 | -1.6 | 0.5 | -1.1 | -1.6 |
| Total sessions with >9 infusions | 1.6 | 1.7 | 4.3 | -0.0 | -1.9 | -0.7 | -0.1 | -2.1 |
| Time in novel zone, NPP test | 1.6 | 1.7 | 3.6 | -0.2 | 1.9 | -1.0 | 1.4 | 1.4 |
| Weight adjusted by age | 1.6 | 1.8 | 3.5 | 1.9 | 0.4 | -1.5 | 1.6 | -0.5 |
| Run reversals in cocaine runway, females | 1.6 | 1.6 | 3.0 | 1.4 | -1.7 | -0.0 | -0.2 | -1.7 |
| Short access day 1 total inactive lever presses | 1.5 | 1.7 | 4.7 | -2.2 | -0.4 | 1.4 | -1.2 | 0.2 |
| Pavlov. Cond. lever latency | 1.5 | 1.9 | 3.0 | 1.3 | 1.7 | -1.2 | 1.6 | 0.9 |
| Bone: elastic displacement | 1.5 | 1.7 | 2.9 | -1.6 | 0.6 | 1.7 | -1.2 | 1.2 |
| Delay disc. indifference point, 24s delay | 1.5 | 1.4 | 4.6 | 0.4 | -1.2 | -0.9 | 0.1 | -2.2 |
| Progressive ratio test 1 breakpoint | 1.4 | 1.5 | 4.0 | 0.1 | -1.6 | -1.0 | 0.1 | -2.0 |
| Novelty place preference | 1.4 | 1.4 | 2.9 | -0.4 | 1.7 | -0.9 | 1.3 | 1.3 |
| Reaction time num false alarms AUC | 1.3 | 1.8 | 3.0 | -1.7 | 1.0 | 1.2 | -0.7 | 1.7 |
| Reaction time false alarm rate | 1.3 | 1.8 | 3.2 | -1.8 | 0.3 | 1.6 | -1.1 | 1.4 |
| Condit. Reinf. lever presses | 1.3 | 1.8 | 2.5 | 1.4 | 1.6 | -1.3 | 1.4 | 0.8 |
| Intermittent access day 15 total infusions | 1.3 | 1.4 | 3.6 | -0.4 | -1.7 | -0.2 | -0.6 | -1.9 |
| Locomotion distance, session 2 | 1.3 | 1.9 | 4.7 | -0.2 | -2.1 | -0.5 | -0.5 | -2.2 |
| Condit. Reinf. inactive responses | 1.3 | 1.5 | 3.6 | -1.9 | -0.4 | 1.4 | -1.3 | 0.0 |
| Total zone transitions, hab. session 2 | 1.3 | 1.7 | 4.3 | 0.4 | -1.8 | 0.2 | -0.9 | -2.1 |
| Novel to familiar place preference ratio | 1.3 | 1.4 | 2.5 | -0.3 | 1.6 | -1.0 | 1.4 | 1.1 |
| Pavlov. Cond. magazine entry latency | 1.3 | 1.7 | 4.5 | -0.1 | -2.1 | 0.9 | -1.3 | -1.2 |
| Bone: cortical area | 1.3 | 1.9 | 4.7 | 2.2 | 1.0 | -1.5 | 1.4 | -0.1 |
| Bone: cortical thickness | 1.3 | 2.1 | 3.6 | 1.9 | 1.5 | -1.4 | 1.5 | 0.8 |
| Time to tail flick, vehicle, after self-admin | 1.3 | 1.3 | 2.2 | -1.2 | -1.2 | 1.3 | -1.5 | -0.2 |
| Delay discounting water rate 0 sec | 1.2 | 2.0 | 4.4 | 1.1 | -1.3 | -1.5 | 0.6 | -2.1 |
| Light reinforcement 1 | 1.2 | 2.2 | 3.9 | 1.8 | 1.0 | -1.7 | 2.0 | 0.2 |
| Degree of sensitization stereotypy | 1.2 | 1.3 | 2.8 | 0.1 | 1.7 | -0.4 | 1.0 | 1.5 |
| Bone: cortical thickness | 1.2 | 1.4 | 3.5 | 0.4 | 1.9 | -0.1 | 0.7 | 1.6 |
| Na content in liver | 1.2 | 1.3 | 3.0 | 0.3 | 1.7 | -0.5 | 1.0 | 1.5 |
| Delay discounting total patch changes 24 sec | 1.1 | 1.4 | 3.1 | 0.6 | 1.8 | -1.0 | 1.4 | 0.7 |
| Cocaine induced anxiety | 1.1 | 1.3 | 2.2 | 0.2 | 1.5 | -0.7 | 1.3 | 1.5 |
| One hour access (shock baseline) | 1.1 | 1.3 | 3.1 | -0.5 | -1.7 | 0.0 | -0.6 | -1.8 |
| Locomotion velocity, NPP test | 1.1 | 1.6 | 4.0 | -0.2 | -1.5 | 0.5 | -1.2 | -2.0 |
| Pavlov. Cond. lever contacts | 1.1 | 1.3 | 2.9 | -0.8 | -1.7 | 0.4 | -1.0 | -1.4 |
| Pavlov. Cond. magazine entry number | 1.1 | 1.4 | 4.2 | 0.0 | 2.1 | -0.7 | 1.2 | 1.0 |
| Bone: trabecular thickness | 1.1 | 1.3 | 3.0 | 1.7 | 0.6 | -1.4 | 1.2 | -0.1 |
| Vertical activity count, locomotor time 1 | 1.1 | 1.1 | 2.1 | 1.2 | -1.0 | -1.0 | 0.2 | -1.4 |
| Reaction time num false alarms | 1.0 | 1.3 | 2.3 | -1.5 | 0.8 | 1.1 | -0.6 | 1.5 |
| Progressive ratio test 1 active lever presses | 1.0 | 1.0 | 2.6 | 0.0 | -1.2 | -1.1 | 0.3 | -1.6 |
| Short access day 10 total inactive lever presses | 1.0 | 1.1 | 2.4 | -0.9 | 1.6 | 0.3 | 0.2 | 1.5 |
| Locomotion distance, session 3 | 1.0 | 1.1 | 2.2 | 1.3 | -0.1 | -1.5 | 1.1 | -0.6 |
| Total locomotion distance, NPP test | 1.0 | 1.3 | 4.2 | 0.2 | -1.3 | 0.1 | -0.8 | -2.0 |
| Bone: stiffness | 1.0 | 1.6 | 5.6 | 2.4 | -0.1 | -1.1 | 0.5 | -1.0 |
| Time in open arm before self-admin | 1.0 | 1.1 | 2.0 | -1.4 | -0.9 | 1.0 | -1.2 | -0.5 |
| Time to tail flick, vehicle, before self-admin | 1.0 | 1.0 | 2.4 | 1.5 | 0.4 | -1.1 | 1.2 | -0.2 |
| Delay disc. indifference point, 16s delay | 1.0 | 1.1 | 2.4 | -0.4 | -1.6 | -0.1 | -0.7 | -1.5 |
| Co content in liver | 1.0 | 1.2 | 2.6 | 1.1 | 0.5 | -1.6 | 1.5 | -0.0 |
| Mean num. licks in bursts | 0.9 | 1.1 | 1.8 | -1.4 | -1.2 | 0.6 | -1.2 | -0.9 |
| Pavlov. Cond. change in total contacts | 0.9 | 1.3 | 3.2 | 1.0 | -0.5 | -1.8 | 0.9 | -1.2 |
| Conditioned reinforcement - actives | 0.9 | 0.9 | 2.1 | 0.1 | -1.4 | 0.3 | -0.9 | -1.2 |
| Short access day 10 total infusions | 0.9 | 1.0 | 2.5 | 0.4 | -0.6 | -1.3 | 0.6 | -1.6 |
| Locomotion velocity, session 7 | 0.9 | 1.0 | 2.7 | 0.7 | 0.2 | -1.6 | 1.2 | -0.5 |
| Bone: elastic work | 0.9 | 1.2 | 2.0 | -1.2 | 0.7 | 1.4 | -1.1 | 1.0 |
| Change in fecal boli incidents, locomotor task | 0.9 | 0.9 | 1.8 | -1.3 | -0.5 | 1.2 | -1.0 | 0.1 |
| Liver weight, left | 0.8 | 1.3 | 2.6 | 0.9 | 0.7 | -1.5 | 1.6 | 0.1 |
| Mean time between licks in bursts | 0.8 | 1.2 | 2.5 | 1.2 | -1.2 | -0.6 | -0.1 | -1.6 |
| Delay discounting total patch changes 0 sec | 0.8 | 1.3 | 3.6 | 0.3 | 1.9 | -0.3 | 0.9 | 1.4 |
| Delay discounting total patch changes 18 sec | 0.8 | 1.0 | 2.7 | 0.2 | 1.6 | -0.2 | 0.8 | 1.3 |
| Delay discounting water rate 18 sec | 0.8 | 1.1 | 2.4 | -0.2 | -1.6 | 0.3 | -0.9 | -1.4 |
| Locomotor testing distance | 0.8 | 1.4 | 2.4 | 1.5 | 0.1 | -1.3 | 0.8 | -1.4 |
| Reaction time mean minus median AUC | 0.8 | 1.0 | 1.9 | -1.2 | -0.3 | 1.4 | -1.3 | -0.1 |
| Intermitt. access day 15 inactive lever presses | 0.8 | 0.9 | 2.2 | -1.5 | 1.1 | 0.1 | 0.3 | 0.9 |
| Incentive Sensitization - Responses | 0.8 | 0.8 | 2.0 | -0.4 | -1.3 | -0.2 | -0.4 | -1.4 |
| Stereotopy head waving duration, day 3 | 0.8 | 1.0 | 1.8 | -1.1 | -0.4 | 1.3 | -1.4 | -0.3 |
| Time in novel zone, hab. session 1 | 0.8 | 0.8 | 1.6 | -0.8 | -0.3 | 1.3 | -1.2 | 0.5 |
| Bone: endosteal estimation | 0.8 | 1.7 | 3.1 | -0.2 | -1.8 | 1.0 | -1.4 | -1.6 |
| Active lever presses in extinction session 6 | 0.8 | 0.8 | 2.7 | -0.1 | -1.0 | 0.1 | -0.6 | -1.6 |
| Locomotion in novel chamber | 0.8 | 1.0 | 3.3 | -0.3 | -1.2 | -0.5 | -0.2 | -1.8 |
| Progressive ratio | 0.8 | 0.9 | 2.3 | -1.1 | -0.1 | 1.5 | -1.0 | 0.6 |
| Run reversals in cocaine runway, males | 0.8 | 0.8 | 1.8 | -1.3 | 0.9 | 0.0 | 0.4 | 1.1 |
| Cu content in liver | 0.8 | 1.0 | 1.6 | 1.0 | 0.9 | -1.3 | 1.2 | 0.1 |
| Delay discounting water rate 12 sec | 0.7 | 1.1 | 2.6 | 0.7 | -0.2 | -1.6 | 0.9 | -1.3 |
| Reaction time premature initiation rate | 0.7 | 1.0 | 1.9 | 1.4 | -1.2 | 0.0 | -0.4 | -1.2 |
| Social time | 0.7 | 0.9 | 1.6 | 0.0 | -1.1 | 0.6 | -1.1 | -1.3 |
| Cocaine response before conditioning | 0.7 | 0.8 | 1.3 | -0.4 | -1.0 | 0.7 | -1.1 | -1.1 |
| Intermittent access intake day 1-15 change | 0.7 | 0.7 | 1.4 | -0.2 | -1.2 | 0.7 | -1.0 | -0.8 |
| Short access day 10 total locomotion | 0.7 | 0.8 | 1.2 | -1.1 | -0.9 | 0.8 | -1.1 | -0.2 |
| Context. condit. distance diff. score | 0.7 | 0.9 | 1.7 | 1.3 | 0.7 | -1.0 | 1.2 | 0.0 |
| Stereotopy head waving bouts, day 7 | 0.7 | 0.8 | 1.9 | 0.1 | 1.4 | -0.5 | 0.9 | 1.0 |
| Bone: marrow area | 0.7 | 1.6 | 3.0 | -0.2 | -1.7 | 0.9 | -1.3 | -1.6 |
| Bone: maximum diameter | 0.7 | 1.3 | 3.1 | 1.8 | 0.2 | -1.2 | 0.9 | -1.1 |
| Tibialis anterior weight | 0.6 | 1.9 | 4.0 | 0.2 | -1.4 | 1.5 | -2.0 | -1.1 |
| Indifference point 0 sec | 0.6 | 1.0 | 3.0 | 0.1 | 1.7 | -0.2 | 0.7 | 1.3 |
| Indifference point AUC | 0.6 | 0.7 | 1.4 | 0.6 | 1.1 | -0.8 | 1.2 | 0.3 |
| Std. dev. reaction times | 0.6 | 0.8 | 2.3 | -0.5 | 0.3 | 1.5 | -1.1 | 0.5 |
| Cocaine response after cond. corrected | 0.6 | 0.7 | 1.1 | -0.6 | 0.9 | -0.7 | 0.9 | 1.1 |
| Pavlov. Cond. response bias | 0.6 | 0.9 | 1.8 | 1.1 | 0.3 | -1.4 | 1.1 | 0.1 |
| Intermittent access intake escalation 2 | 0.6 | 0.6 | 1.0 | -0.5 | -0.9 | 0.8 | -1.0 | -0.4 |
| Intermitt. access escalation Index | 0.6 | 0.6 | 1.5 | -0.3 | 1.0 | 0.6 | -0.0 | 1.2 |
| Incentive Sensitization - Breakpoint | 0.6 | 0.6 | 1.5 | -0.4 | -1.1 | -0.2 | -0.3 | -1.2 |
| Short access day 1 locomotion | 0.6 | 0.7 | 2.1 | 0.2 | -0.7 | -0.8 | 0.2 | -1.5 |
| Locomotion velocity, session 3 | 0.6 | 0.7 | 1.1 | 1.0 | 0.2 | -1.0 | 0.8 | -0.8 |
| Stereotopy head waving duration, day 7 | 0.6 | 0.7 | 1.9 | 0.1 | 1.4 | -0.3 | 0.7 | 1.1 |
| Locomotion velocity, session 8 | 0.6 | 0.7 | 1.7 | 0.4 | 0.0 | -1.3 | 1.1 | -0.7 |
| Bone: periosteal perimeter | 0.6 | 0.9 | 2.2 | 1.5 | 0.2 | -1.1 | 0.8 | -0.8 |
| Ambulatory time after self-admin | 0.6 | 0.6 | 1.2 | 0.6 | -0.6 | -1.1 | 0.7 | -0.9 |
| Fecal boli incidents, locomotor time 1 | 0.6 | 0.6 | 1.2 | 1.1 | 0.4 | -1.0 | 0.9 | -0.2 |
| Rest time, locomotor task time 2 | 0.6 | 0.7 | 1.4 | 0.2 | -0.7 | 1.2 | -1.2 | -0.7 |
| Latency to leave start box in cocaine runway | 0.6 | 0.7 | 1.1 | 1.1 | 0.5 | -1.0 | 0.9 | -0.4 |
| Zn content in liver | 0.6 | 0.7 | 1.5 | 0.7 | -0.3 | -1.2 | 0.8 | -0.8 |
| Reaction time mean | 0.5 | 0.7 | 1.5 | -0.2 | -0.6 | 1.2 | -1.2 | -0.2 |
| Median of all reaction times | 0.5 | 0.7 | 1.2 | 0.1 | -1.0 | 1.0 | -1.1 | -0.6 |
| Reaction time premature initiations | 0.5 | 0.8 | 2.2 | 1.5 | -0.6 | -0.4 | -0.0 | -1.0 |
| Pavlov. Cond. lever contacts | 0.5 | 0.7 | 1.4 | 0.8 | 0.5 | -1.2 | 0.9 | 0.5 |
| Intermittent access day 1 total infusions | 0.5 | 0.5 | 1.4 | -0.5 | -0.9 | -0.3 | -0.2 | -1.2 |
| Short access total locomotion | 0.5 | 0.5 | 0.9 | -0.5 | -1.0 | -0.3 | -0.2 | -1.0 |
| Number of responses in last shaping day | 0.5 | 0.5 | 0.9 | -1.0 | -0.9 | 0.1 | -0.4 | -0.8 |
| Locomotion velocity, session 1 | 0.5 | 0.5 | 1.6 | -1.3 | 0.1 | 0.7 | -0.6 | 0.2 |
| Total zone transitions, NPP test | 0.5 | 0.6 | 1.3 | 1.1 | 0.4 | -1.0 | 0.7 | -0.7 |
| Bone: endosteal perimeter | 0.5 | 1.1 | 2.0 | 1.4 | -0.4 | -1.0 | 0.6 | -1.3 |
| Time to tail flick, test, before self-admin | 0.5 | 0.5 | 0.8 | 0.8 | 0.4 | -0.9 | 0.9 | -0.0 |
| Time >=10cm from walls, locomotor time 1 | 0.5 | 0.5 | 1.3 | 0.2 | 1.1 | 0.2 | 0.3 | 1.1 |
| Distance moved, locomotor task time 1 | 0.5 | 0.5 | 1.3 | -0.3 | -1.2 | 0.2 | -0.7 | -0.9 |
| Food consumed during 24 hour testing period | 0.4 | 0.5 | 0.8 | -0.3 | 0.7 | -0.9 | 0.9 | 0.7 |
| Reaction time mean minus median | 0.4 | 0.5 | 1.0 | -0.5 | 0.6 | 1.0 | -0.7 | 0.5 |
| Reaction time mean AUC | 0.4 | 0.5 | 1.4 | -0.1 | -0.3 | 1.2 | -1.1 | -0.0 |
| Pavlov. Cond. index score | 0.4 | 0.5 | 1.1 | 0.7 | 0.1 | -1.1 | 0.8 | 0.0 |
| Intermittent access intake escalation | 0.4 | 0.4 | 0.7 | -0.4 | -0.8 | 0.7 | -0.8 | -0.3 |
| Time in familiar zone, hab. session 1 | 0.4 | 0.4 | 0.7 | 0.5 | 0.4 | -0.8 | 0.9 | 0.1 |
| Bone volume | 0.4 | 0.6 | 1.7 | 1.3 | -0.2 | -0.5 | 0.1 | -1.0 |
| Distance traveled after self-admin | 0.4 | 0.4 | 0.8 | 0.2 | -0.8 | -0.7 | 0.3 | -0.9 |
| Delta time in open arm before/after self-admin | 0.4 | 0.3 | 0.8 | -0.1 | 0.9 | -0.4 | 0.5 | 0.7 |
| Time in closed arm before self-admin | 0.4 | 0.5 | 1.7 | 1.3 | -0.0 | -0.7 | 0.5 | -0.3 |
| Time in closed arm after self-admin | 0.4 | 0.4 | 1.1 | 1.0 | -0.2 | -0.6 | 0.4 | -0.6 |
| Sum of active levers in priming session hrs 5-6 | 0.4 | 0.4 | 1.1 | 0.4 | -0.9 | -0.5 | -0.1 | -1.0 |
| Delay disc. indifference point, 0s delay | 0.4 | 0.5 | 0.7 | -0.8 | -0.8 | 0.1 | -0.6 | -0.7 |
| Seeking ratio, punishment vs. effort | 0.4 | 0.5 | 1.5 | 0.2 | -0.4 | -1.2 | 0.5 | -0.8 |
| Rb content in liver | 0.4 | 0.5 | 1.3 | -0.8 | 0.6 | 0.4 | -0.1 | 1.1 |
| Heart weight | 0.3 | 0.4 | 1.1 | 0.5 | 0.1 | -1.1 | 0.6 | -0.6 |
| Parametrial fat weight | 0.3 | 0.6 | 1.2 | 1.0 | 1.1 | -0.5 | 0.8 | 0.3 |
| Extensor digitorum longus weight | 0.3 | 1.1 | 2.2 | 1.2 | -1.0 | 0.2 | -0.9 | -1.5 |
| Cocaine response after cond. not corrected | 0.3 | 0.3 | 0.6 | -0.8 | 0.5 | -0.5 | 0.5 | 0.5 |
| Pavlov. Cond. lever latency | 0.3 | 0.4 | 0.6 | -0.4 | -0.6 | 0.8 | -0.7 | -0.7 |
| Pavlov. Cond. magazine entry number | 0.3 | 0.4 | 0.7 | -0.8 | 0.7 | 0.5 | -0.3 | 0.7 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.3 | 0.4 | 1.0 | 0.7 | 0.2 | -1.0 | 0.8 | 0.1 |
| Intermittent access day 1 locomotion | 0.3 | 0.3 | 0.7 | -0.3 | 0.4 | -0.8 | 0.7 | -0.0 |
| Post-drug Anxiety | 0.3 | 0.3 | 0.8 | 0.0 | 0.4 | -0.2 | 0.6 | 0.9 |
| Progressive ratio test 1 inactive lever presses | 0.3 | 0.3 | 0.8 | -0.9 | 0.6 | 0.3 | -0.1 | 0.5 |
| Locomotion distance, session 1 | 0.3 | 0.3 | 0.5 | -0.7 | -0.7 | 0.2 | -0.5 | -0.7 |
| Locomotion distance, session 7 | 0.3 | 0.4 | 1.1 | 0.1 | 0.0 | -1.1 | 0.8 | -0.1 |
| Degree of sensitization distance | 0.3 | 0.3 | 1.0 | -1.0 | 0.3 | 0.4 | -0.1 | 0.6 |
| Time in novel zone, hab. session 2 | 0.3 | 0.3 | 0.4 | -0.5 | 0.4 | 0.6 | -0.5 | 0.6 |
| Bone: periosteal estimation | 0.3 | 0.7 | 1.6 | 1.3 | -0.5 | -0.5 | 0.1 | -1.2 |
| Breakpoint value in progressive ratio session | 0.3 | 0.4 | 0.8 | -0.4 | -0.4 | 0.9 | -0.9 | -0.2 |
| Delta distance traveled before/after self-admin | 0.3 | 0.3 | 0.6 | 0.1 | -0.7 | -0.8 | 0.0 | -0.6 |
| Delta ambulatory time before/after self-admin | 0.3 | 0.3 | 0.6 | -0.5 | -0.8 | -0.3 | -0.5 | -0.5 |
| Time in open arm after self-admin | 0.3 | 0.4 | 0.7 | -0.8 | 0.7 | 0.3 | -0.2 | 0.8 |
| Total heroin consumption | 0.3 | 0.3 | 0.9 | 0.3 | 1.0 | -0.5 | 0.7 | 0.3 |
| Area under the delay curve | 0.3 | 0.3 | 0.6 | -0.8 | -0.8 | -0.2 | -0.3 | -0.6 |
| Delay disc. indifference point, 4s delay | 0.3 | 0.3 | 0.9 | -1.0 | 0.4 | -0.1 | 0.0 | 0.6 |
| Fe content in liver | 0.3 | 0.3 | 0.9 | 0.5 | -0.6 | -0.4 | -0.0 | -0.9 |
| Soleus weight | 0.2 | 0.7 | 2.2 | 1.5 | -0.3 | -0.7 | 0.7 | -0.7 |
| Delay discounting total patch changes 6 sec | 0.2 | 0.2 | 1.0 | -0.2 | 1.0 | 0.2 | 0.1 | 0.3 |
| Delay discounting time to switch 0 sec | 0.2 | 0.3 | 0.8 | 0.3 | -0.1 | 0.9 | -0.7 | 0.3 |
| Light reinforcement 2 | 0.2 | 0.3 | 0.8 | -0.6 | 0.5 | 0.5 | -0.1 | 0.9 |
| Conditioned locomotion | 0.2 | 0.3 | 0.6 | 0.8 | 0.5 | -0.1 | 0.1 | 0.6 |
| Condit. Reinf. active responses | 0.2 | 0.2 | 0.6 | 0.8 | -0.3 | 0.1 | -0.4 | -0.5 |
| Pavlov. Cond. latency score | 0.2 | 0.2 | 0.7 | 0.5 | 0.1 | -0.8 | 0.6 | 0.1 |
| Conditioned locomotion | 0.2 | 0.2 | 0.4 | 0.5 | 0.0 | -0.7 | 0.4 | -0.5 |
| Intermittent access total locomotion | 0.2 | 0.2 | 0.7 | -0.4 | -0.3 | -0.4 | -0.0 | -0.8 |
| Baseline Anxiety | 0.2 | 0.3 | 0.7 | 0.0 | -0.3 | 0.8 | -0.7 | -0.1 |
| Bone: connectivity density | 0.2 | 0.4 | 0.8 | -0.2 | 0.8 | 0.5 | 0.2 | 0.9 |
| Bone: final force | 0.2 | 0.3 | 1.4 | 1.2 | 0.2 | -0.3 | 0.2 | -0.3 |
| Bone: tissue strength | 0.2 | 0.2 | 0.5 | 0.7 | 0.5 | -0.1 | 0.0 | 0.4 |
| Bone: trabecular number | 0.2 | 0.2 | 0.8 | -0.0 | 0.1 | 0.9 | -0.4 | 0.5 |
| Bone: trabecular tissue density | 0.2 | 0.2 | 0.9 | 0.1 | -0.9 | -0.2 | -0.2 | -0.5 |
| Time to tail flick, test, after self-admin | 0.2 | 0.3 | 0.9 | 1.0 | -0.1 | -0.2 | 0.2 | -0.5 |
| Delay disc. indifference point, 2s delay | 0.2 | 0.2 | 0.4 | -0.4 | -0.3 | -0.6 | 0.3 | -0.5 |
| Delay discount exponential model param | 0.2 | 0.3 | 0.4 | 0.6 | 0.6 | 0.4 | 0.1 | 0.6 |
| Delay discount hyperbolic model param | 0.2 | 0.2 | 0.3 | 0.5 | 0.4 | 0.5 | -0.1 | 0.4 |
| Rest time, locomotor task time 1 | 0.2 | 0.2 | 0.5 | -0.3 | 0.4 | 0.7 | -0.4 | 0.4 |
| Time >=10cm from walls, locomotor time 2 | 0.2 | 0.2 | 0.6 | -0.8 | -0.2 | 0.5 | -0.4 | 0.3 |
| Bouts of movement, locomotor time 2 | 0.2 | 0.2 | 0.6 | 0.7 | 0.4 | 0.0 | -0.0 | -0.3 |
| Total resting periods, locomotor time 2 | 0.2 | 0.2 | 0.7 | 0.8 | 0.1 | 0.1 | -0.2 | -0.6 |
| Distance moved, locomotor task time 2 | 0.2 | 0.3 | 0.6 | -0.3 | 0.1 | -0.7 | 0.7 | 0.5 |
| Food seeking constrained by brief footshock | 0.2 | 0.2 | 0.5 | -0.2 | -0.5 | -0.7 | 0.1 | -0.5 |
| K content in liver | 0.2 | 0.2 | 0.4 | -0.3 | 0.7 | 0.0 | 0.1 | 0.6 |
| Mn content in liver | 0.2 | 0.2 | 0.5 | 0.0 | -0.4 | 0.3 | -0.7 | -0.5 |
| Sr content in liver | 0.2 | 0.1 | 0.3 | -0.2 | 0.2 | -0.6 | 0.6 | -0.0 |
| Number of licking bursts | 0.1 | 0.1 | 0.3 | 0.1 | -0.5 | 0.4 | -0.3 | -0.3 |
| Std. dev. time between licks in bursts | 0.1 | 0.1 | 0.4 | 0.6 | -0.5 | -0.2 | 0.1 | -0.2 |
| Water consumed over 24 hours | 0.1 | 0.1 | 0.3 | -0.4 | -0.4 | -0.6 | 0.2 | -0.0 |
| Indifference point function ln k | 0.1 | 0.1 | 0.3 | -0.3 | -0.6 | -0.1 | -0.3 | -0.0 |
| Indifference point function log k | 0.1 | 0.1 | 0.3 | -0.3 | -0.6 | -0.1 | -0.3 | -0.0 |
| Locomotor testing rearing | 0.1 | 0.2 | 0.6 | 0.5 | 0.8 | 0.3 | -0.1 | -0.1 |
| Reaction time number correct | 0.1 | 0.1 | 0.3 | 0.3 | 0.1 | -0.6 | 0.3 | -0.4 |
| Reaction time trials correct on left | 0.1 | 0.1 | 0.3 | 0.3 | 0.1 | -0.6 | 0.3 | -0.4 |
| Reaction time trials on left | 0.1 | 0.1 | 0.2 | 0.2 | 0.2 | -0.5 | 0.2 | -0.4 |
| Reaction time trials completed | 0.1 | 0.1 | 0.2 | 0.2 | 0.2 | -0.5 | 0.2 | -0.4 |
| Reaction time trials AUC | 0.1 | 0.2 | 0.4 | 0.4 | -0.2 | -0.5 | 0.1 | -0.7 |
| Saline control response | 0.1 | 0.1 | 0.4 | -0.2 | 0.1 | -0.6 | 0.2 | -0.3 |
| Condit. Reinf. active minus inactive responses | 0.1 | 0.1 | 0.5 | 0.7 | 0.3 | -0.0 | -0.0 | -0.0 |
| Condit. Reinf. inactive responses | 0.1 | 0.1 | 0.3 | 0.3 | 0.0 | 0.6 | -0.4 | 0.2 |
| Condit. Reinf. lever reinforcers received | 0.1 | 0.2 | 0.8 | 0.9 | -0.2 | -0.0 | -0.2 | -0.5 |
| Pavlov. Cond. magazine entry latency | 0.1 | 0.1 | 0.3 | 0.5 | -0.3 | -0.3 | 0.3 | -0.3 |
| Conditioned reinforcement - inactives | 0.1 | 0.1 | 0.4 | -0.6 | 0.4 | -0.0 | 0.1 | 0.3 |
| Intermittent access day 15 total locomotion | 0.1 | 0.1 | 0.4 | -0.0 | 0.0 | -0.5 | 0.2 | -0.7 |
| Compulsive drug intake | 0.1 | 0.1 | 0.4 | 0.6 | 0.1 | -0.4 | 0.4 | 0.1 |
| Locomotion velocity, session 2 | 0.1 | 0.1 | 0.4 | -0.3 | 0.0 | -0.6 | 0.4 | 0.3 |
| Time in familiar zone, hab. session 2 | 0.1 | 0.1 | 0.2 | 0.3 | -0.1 | -0.2 | 0.2 | -0.4 |
| Bone: apparent density | 0.1 | 0.2 | 0.6 | 0.8 | -0.2 | -0.0 | -0.1 | -0.4 |
| Bone surface | 0.1 | 0.2 | 0.6 | 0.6 | -0.2 | -0.1 | -0.1 | -0.8 |
| Bone: cortical porosity | 0.1 | 0.1 | 0.3 | 0.0 | 0.6 | -0.4 | 0.2 | 0.2 |
| Bone: cortical porosity | 0.1 | 0.1 | 0.2 | 0.2 | 0.1 | -0.4 | 0.0 | -0.3 |
| Bone: final moment | 0.1 | 0.2 | 1.0 | 1.0 | 0.1 | -0.2 | -0.0 | -0.4 |
| Bone: maximum force | 0.1 | 0.2 | 0.9 | 0.9 | 0.4 | -0.0 | -0.0 | -0.1 |
| Bone: maximum moment | 0.1 | 0.1 | 0.5 | 0.7 | 0.2 | 0.1 | -0.3 | -0.3 |
| Bone: post-yield work | 0.1 | 0.1 | 0.2 | -0.3 | 0.4 | 0.3 | -0.0 | 0.4 |
| Bone: trabecular spacing | 0.1 | 0.2 | 0.3 | -0.5 | 0.5 | -0.2 | 0.4 | 0.3 |
| Distance traveled before self-admin | 0.1 | 0.1 | 0.2 | 0.5 | 0.1 | 0.2 | 0.3 | 0.1 |
| Bouts of movement, locomotor time 1 | 0.1 | 0.1 | 0.2 | 0.4 | -0.4 | 0.3 | -0.3 | -0.1 |
| Total resting periods, locomotor time 1 | 0.1 | 0.1 | 0.3 | 0.2 | -0.4 | 0.5 | -0.5 | -0.0 |
| Seeking ratio, delayed vs. immediate footshock | 0.1 | 0.1 | 0.5 | -0.7 | -0.1 | -0.1 | -0.2 | -0.0 |
| Locomotion in novel chamber post-restriction | 0.1 | 0.1 | 0.4 | -0.6 | -0.3 | 0.3 | -0.1 | -0.2 |
| Mg content in liver | 0.1 | 0.1 | 0.1 | -0.3 | 0.4 | 0.2 | -0.2 | 0.3 |
| Se content in liver | 0.1 | 0.1 | 0.3 | 0.0 | -0.4 | -0.4 | 0.2 | -0.5 |
| Glucose | 0.0 | 0.0 | 0.1 | 0.3 | -0.0 | -0.3 | 0.1 | -0.3 |
| Condit. Reinf. active-inactive response ratio | 0.0 | 0.0 | 0.1 | 0.3 | -0.0 | -0.3 | 0.1 | -0.2 |
| Pavlov. Cond. intertrial magazine entries | 0.0 | 0.1 | 0.2 | -0.4 | 0.2 | 0.2 | -0.1 | 0.1 |
| Delta time in closed arm before/after self-admin | 0.0 | 0.0 | 0.1 | -0.1 | -0.2 | 0.2 | -0.2 | -0.2 |
| Delta time to tail flick, test, before/after SA | 0.0 | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | -0.1 | -0.1 |
| Ambulatory time before self-admin | 0.0 | 0.0 | 0.1 | 0.3 | -0.1 | 0.3 | 0.2 | 0.1 |
| Delay disc. indifference point, 8s delay | 0.0 | 0.0 | 0.1 | -0.3 | -0.0 | -0.4 | 0.2 | 0.0 |
| Latency to leave start box in cocaine runway, F | 0.0 | 0.0 | 0.1 | -0.2 | 0.3 | 0.2 | 0.0 | 0.2 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.