Hub : Genes

Elk3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000004367	0.11	0.05	4.2e-10	0.05	0.05	0.05	0.04	5.8e-06	2.5e-06	5.1e-06	1.1e-05
2	Brain	gene expression	ENSRNOG00000004367	0.04	0.03	9.8e-03	0.03	0	0.02	0.01	5.1e-04	9.8e-02	3.9e-03	5.8e-02
3	Eye	isoform ratio	ENSRNOT00000005911	0.36	0.16	6.5e-03	0.01	0.1	-0	0.04	2.0e-01	1.2e-02	3.4e-01	7.3e-02
4	NAcc	gene expression	ENSRNOG00000004367	0.04	0.02	4.5e-03	0	0.02	-0	0	2.6e-01	1.6e-02	4.7e-01	1.4e-01
5	PL	gene expression	ENSRNOG00000004367	0.21	0.08	5.6e-07	0.05	0.07	0.05	0.05	1.2e-04	4.0e-06	7.1e-05	5.9e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	1.6	5.0	8.6	2.9	-0.9	-2.6	1.5	-2.6
BMI without tail	3.9	8.1	14.1	3.8	0.8	-3.7	2.8	-2.1
Body weight	8.9	37.5	68.5	7.7	2.4	-8.3	6.8	-2.8
Epididymis fat weight	2.2	5.1	8.9	2.7	0.9	-3.0	2.9	-0.3
Glucose	0.0	0.0	0.1	0.3	-0.0	-0.3	0.1	-0.3
Heart weight	0.3	0.4	1.1	0.5	0.1	-1.1	0.6	-0.6
Left kidney weight	3.2	9.1	14.9	3.8	1.7	-3.9	3.5	-1.0
Right kidney weight	2.7	7.8	12.7	3.4	1.9	-3.6	3.4	-0.3
Tail length	8.9	27.0	44.2	6.1	3.8	-6.7	6.2	-0.5
Length with tail	11.9	43.8	77.6	7.5	4.4	-8.8	8.1	-0.8
Length without tail	5.7	12.5	24.4	3.9	1.9	-4.9	4.3	-0.5
Liver weight, left	0.8	1.3	2.6	0.9	0.7	-1.5	1.6	0.1
Liver weight, right	1.8	2.9	7.1	2.7	-0.3	-1.9	1.6	-1.1
Parametrial fat weight	0.3	0.6	1.2	1.0	1.1	-0.5	0.8	0.3
Retroperitoneal fat weight	1.9	6.3	11.6	3.2	0.4	-3.4	2.6	-1.6
Intraocular pressure	1.9	2.7	6.7	-2.6	-0.4	2.0	-1.2	1.2
Extensor digitorum longus weight	0.3	1.1	2.2	1.2	-1.0	0.2	-0.9	-1.5
Soleus weight	0.2	0.7	2.2	1.5	-0.3	-0.7	0.7	-0.7
Tibialis anterior weight	0.6	1.9	4.0	0.2	-1.4	1.5	-2.0	-1.1
Tibia length	6.0	16.9	31.4	5.3	0.6	-5.6	4.4	-2.2
Number of licking bursts	0.1	0.1	0.3	0.1	-0.5	0.4	-0.3	-0.3
Food consumed during 24 hour testing period	0.4	0.5	0.8	-0.3	0.7	-0.9	0.9	0.7
Times rat made contact with spout	1.7	1.9	3.8	-0.8	-2.0	0.4	-1.3	-1.8
Mean time between licks in bursts	0.8	1.2	2.5	1.2	-1.2	-0.6	-0.1	-1.6
Mean num. licks in bursts	0.9	1.1	1.8	-1.4	-1.2	0.6	-1.2	-0.9
Std. dev. time between licks in bursts	0.1	0.1	0.4	0.6	-0.5	-0.2	0.1	-0.2
Water consumed over 24 hours	0.1	0.1	0.3	-0.4	-0.4	-0.6	0.2	-0.0
Indifference point 0 sec	0.6	1.0	3.0	0.1	1.7	-0.2	0.7	1.3
Indifference point AUC	0.6	0.7	1.4	0.6	1.1	-0.8	1.2	0.3
Indifference point function ln k	0.1	0.1	0.3	-0.3	-0.6	-0.1	-0.3	-0.0
Indifference point function log k	0.1	0.1	0.3	-0.3	-0.6	-0.1	-0.3	-0.0
Delay discounting total patch changes 0 sec	0.8	1.3	3.6	0.3	1.9	-0.3	0.9	1.4
Delay discounting total patch changes 12 sec	1.9	2.5	4.0	1.5	2.0	-1.4	1.9	0.9
Delay discounting total patch changes 18 sec	0.8	1.0	2.7	0.2	1.6	-0.2	0.8	1.3
Delay discounting total patch changes 24 sec	1.1	1.4	3.1	0.6	1.8	-1.0	1.4	0.7
Delay discounting total patch changes 6 sec	0.2	0.2	1.0	-0.2	1.0	0.2	0.1	0.3
Delay discounting time to switch 0 sec	0.2	0.3	0.8	0.3	-0.1	0.9	-0.7	0.3
Delay discounting water rate 0 sec	1.2	2.0	4.4	1.1	-1.3	-1.5	0.6	-2.1
Delay discounting water rate 12 sec	0.7	1.1	2.6	0.7	-0.2	-1.6	0.9	-1.3
Delay discounting water rate 18 sec	0.8	1.1	2.4	-0.2	-1.6	0.3	-0.9	-1.4
Delay discounting water rate 24 sec	2.0	2.7	4.2	1.9	-0.7	-2.1	1.3	-1.9
Delay discounting water rate 6 sec	4.2	6.1	9.5	3.0	-1.1	-3.1	1.9	-2.7
Locomotor activity	3.4	5.4	9.8	3.1	0.9	-3.0	2.3	-1.5
Locomotor testing distance	0.8	1.4	2.4	1.5	0.1	-1.3	0.8	-1.4
Locomotor testing rearing	0.1	0.2	0.6	0.5	0.8	0.3	-0.1	-0.1
Light reinforcement 1	1.2	2.2	3.9	1.8	1.0	-1.7	2.0	0.2
Light reinforcement 2	0.2	0.3	0.8	-0.6	0.5	0.5	-0.1	0.9
Reaction time number correct	0.1	0.1	0.3	0.3	0.1	-0.6	0.3	-0.4
Reaction time mean minus median	0.4	0.5	1.0	-0.5	0.6	1.0	-0.7	0.5
Reaction time mean minus median AUC	0.8	1.0	1.9	-1.2	-0.3	1.4	-1.3	-0.1
Reaction time num false alarms	1.0	1.3	2.3	-1.5	0.8	1.1	-0.6	1.5
Reaction time num false alarms AUC	1.3	1.8	3.0	-1.7	1.0	1.2	-0.7	1.7
Reaction time trials correct on left	0.1	0.1	0.3	0.3	0.1	-0.6	0.3	-0.4
Reaction time trials on left	0.1	0.1	0.2	0.2	0.2	-0.5	0.2	-0.4
Reaction time mean	0.5	0.7	1.5	-0.2	-0.6	1.2	-1.2	-0.2
Reaction time mean AUC	0.4	0.5	1.4	-0.1	-0.3	1.2	-1.1	-0.0
Median of all reaction times	0.5	0.7	1.2	0.1	-1.0	1.0	-1.1	-0.6
Reaction time omissions	1.8	2.4	5.8	-1.5	0.1	2.4	-1.8	0.8
Reaction time false alarm rate	1.3	1.8	3.2	-1.8	0.3	1.6	-1.1	1.4
Reaction time premature initiation rate	0.7	1.0	1.9	1.4	-1.2	0.0	-0.4	-1.2
Reaction time premature initiations	0.5	0.8	2.2	1.5	-0.6	-0.4	-0.0	-1.0
Std. dev. reaction times	0.6	0.8	2.3	-0.5	0.3	1.5	-1.1	0.5
Reaction time trials completed	0.1	0.1	0.2	0.2	0.2	-0.5	0.2	-0.4
Reaction time trials AUC	0.1	0.2	0.4	0.4	-0.2	-0.5	0.1	-0.7
Social response proportion	3.4	3.7	5.2	2.3	-1.3	-2.3	1.0	-2.3
Social responses	2.3	2.9	6.0	2.2	-0.9	-1.7	0.5	-2.4
Social time	0.7	0.9	1.6	0.0	-1.1	0.6	-1.1	-1.3
Conditioned locomotion	0.2	0.3	0.6	0.8	0.5	-0.1	0.1	0.6
Cocaine response after cond. corrected	0.6	0.7	1.1	-0.6	0.9	-0.7	0.9	1.1
Cocaine response after cond. not corrected	0.3	0.3	0.6	-0.8	0.5	-0.5	0.5	0.5
Cocaine response before conditioning	0.7	0.8	1.3	-0.4	-1.0	0.7	-1.1	-1.1
Saline control response	0.1	0.1	0.4	-0.2	0.1	-0.6	0.2	-0.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.5	0.7	0.3	-0.0	-0.0	-0.0
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.3	-0.0	-0.3	0.1	-0.2
Condit. Reinf. active responses	0.2	0.2	0.6	0.8	-0.3	0.1	-0.4	-0.5
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.3	0.0	0.6	-0.4	0.2
Condit. Reinf. lever presses	1.3	1.8	2.5	1.4	1.6	-1.3	1.4	0.8
Condit. Reinf. lever reinforcers received	0.1	0.2	0.8	0.9	-0.2	-0.0	-0.2	-0.5
Pavlov. Cond. lever latency	0.3	0.4	0.6	-0.4	-0.6	0.8	-0.7	-0.7
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	0.5	-0.3	-0.3	0.3	-0.3
Pavlov. Cond. change in total contacts	0.9	1.3	3.2	1.0	-0.5	-1.8	0.9	-1.2
Pavlov. Cond. index score	0.4	0.5	1.1	0.7	0.1	-1.1	0.8	0.0
Pavlov. Cond. latency score	0.2	0.2	0.7	0.5	0.1	-0.8	0.6	0.1
Pavlov. Cond. lever contacts	0.5	0.7	1.4	0.8	0.5	-1.2	0.9	0.5
Pavlov. Cond. magazine entry number	0.3	0.4	0.7	-0.8	0.7	0.5	-0.3	0.7
Pavlov. Cond. intertrial magazine entries	1.7	2.2	4.4	1.7	2.1	-0.8	1.4	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.0	0.7	0.2	-1.0	0.8	0.1
Pavlov. Cond. response bias	0.6	0.9	1.8	1.1	0.3	-1.4	1.1	0.1
Conditioned reinforcement - actives	0.9	0.9	2.1	0.1	-1.4	0.3	-0.9	-1.2
Conditioned reinforcement - inactives	0.1	0.1	0.4	-0.6	0.4	-0.0	0.1	0.3
Conditioned locomotion	0.2	0.2	0.4	0.5	0.0	-0.7	0.4	-0.5
Intermittent access intake day 1-15 change	0.7	0.7	1.4	-0.2	-1.2	0.7	-1.0	-0.8
Intermittent access intake escalation	0.4	0.4	0.7	-0.4	-0.8	0.7	-0.8	-0.3
Intermittent access intake escalation 2	0.6	0.6	1.0	-0.5	-0.9	0.8	-1.0	-0.4
Intermitt. access day 1 inactive lever presses	3.9	4.2	11.0	-3.3	0.8	1.9	-1.5	1.8
Intermitt. access day 15 inactive lever presses	0.8	0.9	2.2	-1.5	1.1	0.1	0.3	0.9
Intermitt. access escalation Index	0.6	0.6	1.5	-0.3	1.0	0.6	-0.0	1.2
Intermittent access day 1 total infusions	0.5	0.5	1.4	-0.5	-0.9	-0.3	-0.2	-1.2
Intermittent access day 15 total infusions	1.3	1.4	3.6	-0.4	-1.7	-0.2	-0.6	-1.9
Intermittent access terminal intake (last 3 days)	1.8	2.0	5.6	-0.2	-2.0	-0.3	-0.6	-2.4
Intermittent access total infusions	2.2	2.5	5.9	-0.8	-2.3	-0.2	-0.8	-2.4
Intermittent access day 1 locomotion	0.3	0.3	0.7	-0.3	0.4	-0.8	0.7	-0.0
Intermittent access day 15 total locomotion	0.1	0.1	0.4	-0.0	0.0	-0.5	0.2	-0.7
Intermittent access total locomotion	0.2	0.2	0.7	-0.4	-0.3	-0.4	-0.0	-0.8
Intermittent access standard deviation	1.8	2.0	5.1	-0.6	-2.3	0.1	-0.8	-1.9
Cocaine induced anxiety	1.1	1.3	2.2	0.2	1.5	-0.7	1.3	1.5
Post-drug Anxiety	0.3	0.3	0.8	0.0	0.4	-0.2	0.6	0.9
Baseline Anxiety	0.2	0.3	0.7	0.0	-0.3	0.8	-0.7	-0.1
Lifetime Intake	2.0	2.3	5.8	-0.2	-2.2	-0.4	-0.6	-2.4
Incentive Sensitization - Responses	0.8	0.8	2.0	-0.4	-1.3	-0.2	-0.4	-1.4
Incentive Sensitization - Breakpoint	0.6	0.6	1.5	-0.4	-1.1	-0.2	-0.3	-1.2
Progressive ratio test 1 active lever presses	1.0	1.0	2.6	0.0	-1.2	-1.1	0.3	-1.6
Progressive ratio test 1 breakpoint	1.4	1.5	4.0	0.1	-1.6	-1.0	0.1	-2.0
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.8	-0.9	0.6	0.3	-0.1	0.5
Progressive ratio test 2 active lever presses	2.0	2.1	5.0	-0.4	-2.2	-0.3	-0.7	-2.2
Progressive ratio test 2 breakpoint	1.8	2.0	4.7	-0.3	-2.1	-0.3	-0.7	-2.2
Progressive ratio test 2 inactive lever presses	1.6	1.8	2.6	-1.6	-1.6	0.5	-1.1	-1.6
Total sessions with >9 infusions	1.6	1.7	4.3	-0.0	-1.9	-0.7	-0.1	-2.1
Short access day 1 total inactive lever presses	1.5	1.7	4.7	-2.2	-0.4	1.4	-1.2	0.2
Short access day 10 total inactive lever presses	1.0	1.1	2.4	-0.9	1.6	0.3	0.2	1.5
Short access day 1 total infusions	2.1	2.2	5.4	0.4	-2.2	-0.2	-0.6	-2.3
Short access day 10 total infusions	0.9	1.0	2.5	0.4	-0.6	-1.3	0.6	-1.6
Short access total infusions	2.4	2.7	6.9	0.8	-2.2	-1.0	-0.1	-2.6
Short access day 1 locomotion	0.6	0.7	2.1	0.2	-0.7	-0.8	0.2	-1.5
Short access day 10 total locomotion	0.7	0.8	1.2	-1.1	-0.9	0.8	-1.1	-0.2
Short access total locomotion	0.5	0.5	0.9	-0.5	-1.0	-0.3	-0.2	-1.0
Compulsive drug intake	0.1	0.1	0.4	0.6	0.1	-0.4	0.4	0.1
One hour access (0.3 mA shock)	3.2	3.7	9.0	-0.1	-3.0	-0.1	-1.0	-2.9
One hour access (shock baseline)	1.1	1.3	3.1	-0.5	-1.7	0.0	-0.6	-1.8
Number of responses in last shaping day	0.5	0.5	0.9	-1.0	-0.9	0.1	-0.4	-0.8
Context. condit. distance diff. score	0.7	0.9	1.7	1.3	0.7	-1.0	1.2	0.0
Locomotion velocity, session 1	0.5	0.5	1.6	-1.3	0.1	0.7	-0.6	0.2
Locomotion distance, session 1	0.3	0.3	0.5	-0.7	-0.7	0.2	-0.5	-0.7
Locomotion velocity, session 2	0.1	0.1	0.4	-0.3	0.0	-0.6	0.4	0.3
Locomotion distance, session 2	1.3	1.9	4.7	-0.2	-2.1	-0.5	-0.5	-2.2
Locomotion velocity, session 3	0.6	0.7	1.1	1.0	0.2	-1.0	0.8	-0.8
Locomotion distance, session 3	1.0	1.1	2.2	1.3	-0.1	-1.5	1.1	-0.6
Stereotopy head waving bouts, day 3	1.8	2.2	4.0	-1.4	-1.2	1.9	-2.0	-0.4
Stereotopy head waving duration, day 3	0.8	1.0	1.8	-1.1	-0.4	1.3	-1.4	-0.3
Locomotion velocity, session 7	0.9	1.0	2.7	0.7	0.2	-1.6	1.2	-0.5
Locomotion distance, session 7	0.3	0.4	1.1	0.1	0.0	-1.1	0.8	-0.1
Stereotopy head waving bouts, day 7	0.7	0.8	1.9	0.1	1.4	-0.5	0.9	1.0
Stereotopy head waving duration, day 7	0.6	0.7	1.9	0.1	1.4	-0.3	0.7	1.1
Locomotion velocity, session 8	0.6	0.7	1.7	0.4	0.0	-1.3	1.1	-0.7
Locomotion distance, session 8	2.3	3.4	5.6	1.9	-1.1	-2.2	1.4	-2.4
Degree of sensitization distance	0.3	0.3	1.0	-1.0	0.3	0.4	-0.1	0.6
Degree of sensitization stereotypy	1.2	1.3	2.8	0.1	1.7	-0.4	1.0	1.5
Condit. Reinf. active minus inactive responses	3.5	3.9	5.9	-1.6	-2.2	2.1	-2.4	-1.4
Condit. Reinf. active-inactive response ratio	3.1	3.3	5.8	-1.5	-1.9	2.1	-2.4	-0.8
Condit. Reinf. active responses	4.9	6.0	9.1	-2.7	-2.2	2.7	-3.0	-1.3
Condit. Reinf. inactive responses	1.3	1.5	3.6	-1.9	-0.4	1.4	-1.3	0.0
Incentive salience index mean	4.0	4.9	8.4	-1.5	-2.9	1.5	-2.3	-2.5
Condit. Reinf. lever presses	2.2	3.0	7.0	-0.4	-2.6	0.2	-1.1	-2.6
Time in familiar zone, hab. session 1	0.4	0.4	0.7	0.5	0.4	-0.8	0.9	0.1
Time in novel zone, hab. session 1	0.8	0.8	1.6	-0.8	-0.3	1.3	-1.2	0.5
Total zone transitions, hab. session 1	2.4	3.4	10.5	1.6	-1.7	-1.0	-0.2	-3.2
Total locomotion distance, hab. session 1	3.1	4.4	14.3	1.3	-2.3	-0.6	-0.7	-3.8
Locomotion velocity, hab. session 1	4.3	6.2	20.5	1.3	-2.8	-0.6	-0.9	-4.5
Time in familiar zone, hab. session 2	0.1	0.1	0.2	0.3	-0.1	-0.2	0.2	-0.4
Time in novel zone, hab. session 2	0.3	0.3	0.4	-0.5	0.4	0.6	-0.5	0.6
Total zone transitions, hab. session 2	1.3	1.7	4.3	0.4	-1.8	0.2	-0.9	-2.1
Total locomotion distance, hab. session 2	3.0	3.9	7.9	0.0	-2.7	0.9	-1.9	-2.8
Locomotion velocity, hab. session 2	3.1	4.2	8.8	0.1	-2.8	0.9	-1.9	-3.0
Novel to familiar place preference ratio	1.3	1.4	2.5	-0.3	1.6	-1.0	1.4	1.1
Novelty place preference	1.4	1.4	2.9	-0.4	1.7	-0.9	1.3	1.3
Time in novel zone, NPP test	1.6	1.7	3.6	-0.2	1.9	-1.0	1.4	1.4
Total zone transitions, NPP test	0.5	0.6	1.3	1.1	0.4	-1.0	0.7	-0.7
Total locomotion distance, NPP test	1.0	1.3	4.2	0.2	-1.3	0.1	-0.8	-2.0
Locomotion velocity, NPP test	1.1	1.6	4.0	-0.2	-1.5	0.5	-1.2	-2.0
Pavlov. Cond. lever latency	1.5	1.9	3.0	1.3	1.7	-1.2	1.6	0.9
Pavlov. Cond. magazine entry latency	1.3	1.7	4.5	-0.1	-2.1	0.9	-1.3	-1.2
Pavlov. Cond. change in total contacts	3.1	3.3	7.0	-1.3	-2.7	1.5	-2.1	-1.1
Pavlov. Cond. index score	1.7	2.2	5.4	-0.9	-2.3	0.9	-1.5	-1.4
Pavlov. Cond. latency score	2.0	2.5	5.7	-1.1	-2.4	1.0	-1.6	-1.5
Pavlov. Cond. lever contacts	1.1	1.3	2.9	-0.8	-1.7	0.4	-1.0	-1.4
Pavlov. Cond. magazine entry number	1.1	1.4	4.2	0.0	2.1	-0.7	1.2	1.0
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.2	-0.4	0.2	0.2	-0.1	0.1
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.1	5.4	-0.7	-2.3	0.7	-1.4	-1.5
Pavlov. Cond. response bias	1.7	2.1	5.3	-0.5	-2.3	0.8	-1.4	-1.5
Bone: apparent density	0.1	0.2	0.6	0.8	-0.2	-0.0	-0.1	-0.4
Bone surface	0.1	0.2	0.6	0.6	-0.2	-0.1	-0.1	-0.8
Bone volume	0.4	0.6	1.7	1.3	-0.2	-0.5	0.1	-1.0
Bone: connectivity density	0.2	0.4	0.8	-0.2	0.8	0.5	0.2	0.9
Bone: cortical apparent density	1.8	2.4	4.5	2.1	1.0	-1.7	1.9	0.4
Bone: cortical area	1.3	1.9	4.7	2.2	1.0	-1.5	1.4	-0.1
Bone: cortical porosity	0.1	0.1	0.3	0.0	0.6	-0.4	0.2	0.2
Bone: cortical porosity	0.1	0.1	0.2	0.2	0.1	-0.4	0.0	-0.3
Bone: cortical thickness	1.3	2.1	3.6	1.9	1.5	-1.4	1.5	0.8
Bone: cortical thickness	1.2	1.4	3.5	0.4	1.9	-0.1	0.7	1.6
Bone: cortical tissue density	1.8	2.4	4.3	2.1	1.0	-1.7	1.9	0.4
Bone: elastic displacement	1.5	1.7	2.9	-1.6	0.6	1.7	-1.2	1.2
Bone: elastic work	0.9	1.2	2.0	-1.2	0.7	1.4	-1.1	1.0
Bone: endosteal estimation	0.8	1.7	3.1	-0.2	-1.8	1.0	-1.4	-1.6
Bone: endosteal perimeter	0.5	1.1	2.0	1.4	-0.4	-1.0	0.6	-1.3
Bone: final force	0.2	0.3	1.4	1.2	0.2	-0.3	0.2	-0.3
Bone: final moment	0.1	0.2	1.0	1.0	0.1	-0.2	-0.0	-0.4
Bone: marrow area	0.7	1.6	3.0	-0.2	-1.7	0.9	-1.3	-1.6
Bone: maximum diameter	0.7	1.3	3.1	1.8	0.2	-1.2	0.9	-1.1
Bone: maximum force	0.1	0.2	0.9	0.9	0.4	-0.0	-0.0	-0.1
Bone: maximum moment	0.1	0.1	0.5	0.7	0.2	0.1	-0.3	-0.3
Bone: minimum diameter	2.3	4.3	10.1	3.2	0.1	-2.4	1.8	-1.5
Bone: periosteal estimation	0.3	0.7	1.6	1.3	-0.5	-0.5	0.1	-1.2
Bone: periosteal perimeter	0.6	0.9	2.2	1.5	0.2	-1.1	0.8	-0.8
Bone: post-yield work	0.1	0.1	0.2	-0.3	0.4	0.3	-0.0	0.4
Bone: stiffness	1.0	1.6	5.6	2.4	-0.1	-1.1	0.5	-1.0
Bone: tissue strength	0.2	0.2	0.5	0.7	0.5	-0.1	0.0	0.4
Bone: trabecular number	0.2	0.2	0.8	-0.0	0.1	0.9	-0.4	0.5
Bone: trabecular spacing	0.1	0.2	0.3	-0.5	0.5	-0.2	0.4	0.3
Bone: trabecular thickness	1.1	1.3	3.0	1.7	0.6	-1.4	1.2	-0.1
Bone: trabecular tissue density	0.2	0.2	0.9	0.1	-0.9	-0.2	-0.2	-0.5
Breakpoint value in progressive ratio session	0.3	0.4	0.8	-0.4	-0.4	0.9	-0.9	-0.2
Distance traveled before self-admin	0.1	0.1	0.2	0.5	0.1	0.2	0.3	0.1
Distance traveled after self-admin	0.4	0.4	0.8	0.2	-0.8	-0.7	0.3	-0.9
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	-0.1	-0.2	0.2	-0.2	-0.2
Delta time in open arm before/after self-admin	0.4	0.3	0.8	-0.1	0.9	-0.4	0.5	0.7
Diff in mean of infusions in LGA sessions	1.8	2.1	3.6	-1.9	-0.2	1.8	-1.8	0.4
Extinction: sum of active levers before priming	1.8	1.8	3.4	-1.8	-1.0	1.4	-1.5	-0.7
Active lever presses in extinction session 6	0.8	0.8	2.7	-0.1	-1.0	0.1	-0.6	-1.6
Delta distance traveled before/after self-admin	0.3	0.3	0.6	0.1	-0.7	-0.8	0.0	-0.6
Delta ambulatory time before/after self-admin	0.3	0.3	0.6	-0.5	-0.8	-0.3	-0.5	-0.5
Time in closed arm before self-admin	0.4	0.5	1.7	1.3	-0.0	-0.7	0.5	-0.3
Time in closed arm after self-admin	0.4	0.4	1.1	1.0	-0.2	-0.6	0.4	-0.6
Time in open arm before self-admin	1.0	1.1	2.0	-1.4	-0.9	1.0	-1.2	-0.5
Time in open arm after self-admin	0.3	0.4	0.7	-0.8	0.7	0.3	-0.2	0.8
Sum of active levers in priming session hrs 5-6	0.4	0.4	1.1	0.4	-0.9	-0.5	-0.1	-1.0
Time to tail flick, vehicle, before self-admin	1.0	1.0	2.4	1.5	0.4	-1.1	1.2	-0.2
Time to tail flick, vehicle, after self-admin	1.3	1.3	2.2	-1.2	-1.2	1.3	-1.5	-0.2
Time to tail flick, test, before self-admin	0.5	0.5	0.8	0.8	0.4	-0.9	0.9	-0.0
Time to tail flick, test, after self-admin	0.2	0.3	0.9	1.0	-0.1	-0.2	0.2	-0.5
Delta time to tail flick, vehicle, before/after SA	2.1	2.1	4.5	-2.1	-1.2	1.3	-1.7	-0.2
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	0.1	-0.1	0.1	-0.1	-0.1
Ambulatory time before self-admin	0.0	0.0	0.1	0.3	-0.1	0.3	0.2	0.1
Ambulatory time after self-admin	0.6	0.6	1.2	0.6	-0.6	-1.1	0.7	-0.9
Total heroin consumption	0.3	0.3	0.9	0.3	1.0	-0.5	0.7	0.3
Area under the delay curve	0.3	0.3	0.6	-0.8	-0.8	-0.2	-0.3	-0.6
Delay disc. indifference point, 0s delay	0.4	0.5	0.7	-0.8	-0.8	0.1	-0.6	-0.7
Delay disc. indifference point, 16s delay	1.0	1.1	2.4	-0.4	-1.6	-0.1	-0.7	-1.5
Delay disc. indifference point, 2s delay	0.2	0.2	0.4	-0.4	-0.3	-0.6	0.3	-0.5
Delay disc. indifference point, 24s delay	1.5	1.4	4.6	0.4	-1.2	-0.9	0.1	-2.2
Delay disc. indifference point, 4s delay	0.3	0.3	0.9	-1.0	0.4	-0.1	0.0	0.6
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.3	-0.0	-0.4	0.2	0.0
Delay discount exponential model param	0.2	0.3	0.4	0.6	0.6	0.4	0.1	0.6
Delay discount hyperbolic model param	0.2	0.2	0.3	0.5	0.4	0.5	-0.1	0.4
Fecal boli incidents, locomotor time 1	0.6	0.6	1.2	1.1	0.4	-1.0	0.9	-0.2
Change in fecal boli incidents, locomotor task	0.9	0.9	1.8	-1.3	-0.5	1.2	-1.0	0.1
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.3	0.2	1.1	0.2	0.3	1.1
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.4	-0.4	0.3	-0.3	-0.1
Total resting periods, locomotor time 1	0.1	0.1	0.3	0.2	-0.4	0.5	-0.5	-0.0
Rest time, locomotor task time 1	0.2	0.2	0.5	-0.3	0.4	0.7	-0.4	0.4
Distance moved, locomotor task time 1	0.5	0.5	1.3	-0.3	-1.2	0.2	-0.7	-0.9
Vertical activity count, locomotor time 1	1.1	1.1	2.1	1.2	-1.0	-1.0	0.2	-1.4
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.6	-0.8	-0.2	0.5	-0.4	0.3
Bouts of movement, locomotor time 2	0.2	0.2	0.6	0.7	0.4	0.0	-0.0	-0.3
Total resting periods, locomotor time 2	0.2	0.2	0.7	0.8	0.1	0.1	-0.2	-0.6
Rest time, locomotor task time 2	0.6	0.7	1.4	0.2	-0.7	1.2	-1.2	-0.7
Distance moved, locomotor task time 2	0.2	0.3	0.6	-0.3	0.1	-0.7	0.7	0.5
Vertical activity count, locomotor time 2	1.8	2.0	5.3	1.4	-0.0	-2.3	1.4	-0.8
Weight adjusted by age	1.6	1.8	3.5	1.9	0.4	-1.5	1.6	-0.5
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.5	-0.7	-0.1	-0.1	-0.2	-0.0
Locomotion in novel chamber	0.8	1.0	3.3	-0.3	-1.2	-0.5	-0.2	-1.8
Locomotion in novel chamber post-restriction	0.1	0.1	0.4	-0.6	-0.3	0.3	-0.1	-0.2
Progressive ratio	0.8	0.9	2.3	-1.1	-0.1	1.5	-1.0	0.6
Food seeking constrained by brief footshock	0.2	0.2	0.5	-0.2	-0.5	-0.7	0.1	-0.5
Seeking ratio, punishment vs. effort	0.4	0.5	1.5	0.2	-0.4	-1.2	0.5	-0.8
Run reversals in cocaine runway, females	1.6	1.6	3.0	1.4	-1.7	-0.0	-0.2	-1.7
Run reversals in cocaine runway, males	0.8	0.8	1.8	-1.3	0.9	0.0	0.4	1.1
Latency to leave start box in cocaine runway	0.6	0.7	1.1	1.1	0.5	-1.0	0.9	-0.4
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	-0.2	0.3	0.2	0.0	0.2
Latency to leave start box in cocaine runway, M	3.7	3.5	6.0	2.4	1.1	-2.4	2.1	-0.5
Cd content in liver	1.8	1.9	3.5	1.9	-1.2	-1.3	0.4	-1.7
Co content in liver	1.0	1.2	2.6	1.1	0.5	-1.6	1.5	-0.0
Cu content in liver	0.8	1.0	1.6	1.0	0.9	-1.3	1.2	0.1
Fe content in liver	0.3	0.3	0.9	0.5	-0.6	-0.4	-0.0	-0.9
K content in liver	0.2	0.2	0.4	-0.3	0.7	0.0	0.1	0.6
Mg content in liver	0.1	0.1	0.1	-0.3	0.4	0.2	-0.2	0.3
Mn content in liver	0.2	0.2	0.5	0.0	-0.4	0.3	-0.7	-0.5
Na content in liver	1.2	1.3	3.0	0.3	1.7	-0.5	1.0	1.5
Rb content in liver	0.4	0.5	1.3	-0.8	0.6	0.4	-0.1	1.1
Se content in liver	0.1	0.1	0.3	0.0	-0.4	-0.4	0.2	-0.5
Sr content in liver	0.2	0.1	0.3	-0.2	0.2	-0.6	0.6	-0.0
Zn content in liver	0.6	0.7	1.5	0.7	-0.3	-1.2	0.8	-0.8