Hub : Genes

Cnr1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000008223	0.06	0.07	1.4e-05	0.03	0.03	0.02	0.03	3.2e-04	3.1e-04	1.3e-03	4.5e-04
2	Brain	gene expression	ENSRNOG00000008223	0.38	0.17	3.9e-16	0.17	0.19	0.17	0.18	1.5e-15	2.3e-17	7.4e-16	1.1e-16
3	Eye	gene expression	ENSRNOG00000008223	0.88	0.09	4.7e-03	0.02	0.08	0.13	0.01	1.6e-01	2.1e-02	4.8e-03	2.3e-01
4	IL	mRNA stability	ENSRNOG00000008223	0.23	0.18	7.4e-04	0.07	0.06	0.04	0.08	8.5e-03	1.8e-02	3.1e-02	5.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
BMI with tail	2.3	7.4	10.4	3.2	-2.6	-1.5	-3.2
BMI without tail	2.8	5.8	7.8	2.6	-2.8	-1.7	-2.4
Body weight	4.5	19.0	26.6	5.2	-4.4	-2.1	-5.1
Epididymis fat weight	0.1	0.1	0.4	-0.2	0.6	-0.3	0.3
Glucose	0.0	0.0	0.0	-0.0	-0.1	-0.2	0.1
Heart weight	0.8	1.2	1.7	1.1	-0.9	-1.3	-1.0
Left kidney weight	2.0	5.7	7.4	2.7	-2.5	-1.3	-2.7
Right kidney weight	2.1	6.0	7.9	2.8	-2.6	-1.3	-2.8
Tail length	0.8	2.4	3.9	1.6	-2.0	-1.0	-1.5
Length with tail	1.7	6.4	8.9	3.0	-2.6	-1.0	-3.0
Length without tail	0.9	1.9	3.8	1.8	-0.8	0.2	-1.9
Liver weight, left	0.1	0.2	0.4	-0.3	0.2	0.6	0.3
Liver weight, right	0.5	0.8	2.2	-0.6	0.6	1.5	0.5
Parametrial fat weight	0.6	1.1	1.5	-1.2	1.0	-0.8	1.2
Retroperitoneal fat weight	0.8	2.6	3.8	-1.7	2.0	0.8	1.7
Intraocular pressure	6.9	9.7	14.9	2.7	-3.5	-3.9	-2.0
Extensor digitorum longus weight	3.2	12.8	17.6	4.2	-3.7	-1.5	-4.2
Soleus weight	1.1	3.3	5.0	2.2	-1.9	-0.4	-2.2
Tibialis anterior weight	4.9	16.9	23.4	4.8	-4.3	-1.5	-4.8
Tibia length	1.3	3.6	4.4	2.1	-2.0	-1.4	-2.0
Number of licking bursts	0.3	0.4	0.5	-0.6	0.7	0.7	0.6
Food consumed during 24 hour testing period	1.2	1.4	2.0	1.4	-1.3	-0.5	-1.4
Times rat made contact with spout	0.1	0.1	0.3	-0.0	0.2	0.5	0.0
Mean time between licks in bursts	0.5	0.7	1.0	0.8	-1.0	-0.5	-0.8
Mean num. licks in bursts	0.3	0.3	0.4	0.6	-0.6	-0.4	-0.5
Std. dev. time between licks in bursts	0.3	0.3	0.6	0.7	-0.5	0.2	-0.8
Water consumed over 24 hours	1.0	1.2	1.8	1.3	-1.1	0.1	-1.3
Indifference point 0 sec	0.2	0.3	0.7	0.6	-0.2	0.2	-0.8
Indifference point AUC	1.1	1.3	2.2	1.3	-1.5	-0.1	-1.2
Indifference point function ln k	0.3	0.4	1.0	-0.6	1.0	-0.2	0.5
Indifference point function log k	0.3	0.4	1.0	-0.6	1.0	-0.2	0.5
Delay discounting total patch changes 0 sec	0.2	0.3	0.5	0.4	0.0	0.7	-0.7
Delay discounting total patch changes 12 sec	1.8	2.4	3.6	1.7	-1.9	-0.8	-1.6
Delay discounting total patch changes 18 sec	0.6	0.8	2.6	0.4	-0.2	1.6	-0.6
Delay discounting total patch changes 24 sec	1.0	1.3	1.9	1.3	-1.2	0.3	-1.4
Delay discounting total patch changes 6 sec	0.7	1.1	1.5	1.2	-1.2	-0.3	-1.1
Delay discounting time to switch 0 sec	1.1	1.7	3.0	-1.6	1.1	-0.3	1.7
Delay discounting water rate 0 sec	1.1	1.7	2.5	1.5	-1.4	-0.2	-1.6
Delay discounting water rate 12 sec	0.3	0.4	1.4	0.1	0.3	1.2	-0.4
Delay discounting water rate 18 sec	0.5	0.6	2.3	-0.1	0.2	1.5	-0.2
Delay discounting water rate 24 sec	0.1	0.1	0.5	0.1	-0.0	-0.7	-0.0
Delay discounting water rate 6 sec	0.2	0.2	0.6	0.5	0.1	0.2	-0.8
Locomotor activity	0.4	0.7	1.0	-0.9	0.8	-0.3	1.0
Locomotor testing distance	0.2	0.3	0.6	-0.6	0.5	-0.1	0.8
Locomotor testing rearing	0.9	1.4	1.7	-1.1	1.3	1.2	1.1
Light reinforcement 1	2.0	3.7	7.4	1.9	-2.7	-1.1	-1.5
Light reinforcement 2	1.0	1.3	2.0	1.4	-1.1	-0.0	-1.4
Reaction time number correct	0.4	0.6	1.2	0.8	-0.6	0.5	-1.1
Reaction time mean minus median	0.9	1.1	1.7	-1.1	1.1	-0.7	1.3
Reaction time mean minus median AUC	0.8	1.0	1.5	-1.1	1.1	0.1	1.2
Reaction time num false alarms	0.8	1.1	2.2	1.0	-0.8	-1.5	-0.8
Reaction time num false alarms AUC	0.8	1.2	1.5	1.1	-0.9	-1.2	-1.0
Reaction time trials correct on left	0.4	0.6	1.2	0.8	-0.6	0.5	-1.1
Reaction time trials on left	0.5	0.7	1.4	0.9	-0.6	0.5	-1.2
Reaction time mean	0.4	0.6	1.6	0.6	-0.4	-1.3	-0.5
Reaction time mean AUC	0.2	0.3	0.7	0.4	-0.2	-0.8	-0.4
Median of all reaction times	0.9	1.2	1.6	1.1	-0.9	-1.3	-1.1
Reaction time omissions	0.4	0.6	1.4	0.9	-0.1	0.4	-1.2
Reaction time false alarm rate	0.6	0.8	2.9	0.3	-0.5	-1.7	0.0
Reaction time premature initiation rate	0.2	0.2	0.4	0.5	-0.4	-0.2	-0.6
Reaction time premature initiations	0.7	1.0	1.9	1.1	-0.9	0.0	-1.4
Std. dev. reaction times	0.4	0.5	0.9	-0.8	0.9	-0.3	0.8
Reaction time trials completed	0.5	0.7	1.4	0.9	-0.6	0.5	-1.2
Reaction time trials AUC	0.5	0.7	1.3	0.9	-0.6	0.5	-1.2
Social response proportion	1.7	1.8	2.6	-1.5	1.6	0.2	1.5
Social responses	0.9	1.2	2.7	-0.6	1.2	1.6	0.2
Social time	0.3	0.3	0.8	-0.4	0.6	0.9	0.3
Conditioned locomotion	0.2	0.2	0.6	0.1	-0.1	0.8	-0.3
Cocaine response after cond. corrected	0.3	0.3	0.4	0.6	-0.5	0.5	-0.6
Cocaine response after cond. not corrected	0.3	0.4	1.4	0.0	0.1	1.2	-0.1
Cocaine response before conditioning	0.3	0.4	0.6	-0.5	0.8	0.8	0.3
Saline control response	0.7	0.9	1.5	1.0	-0.7	0.8	-1.2
Condit. Reinf. active minus inactive responses	0.8	1.0	3.1	0.3	0.5	1.8	-0.8
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.8	0.1	0.0	0.9	-0.2
Condit. Reinf. active responses	0.8	1.1	3.0	0.5	0.5	1.7	-0.9
Condit. Reinf. inactive responses	0.3	0.3	0.6	0.3	0.5	0.8	-0.6
Condit. Reinf. lever presses	0.8	1.1	2.4	1.1	-0.2	0.9	-1.5
Condit. Reinf. lever reinforcers received	0.8	1.1	2.1	0.8	0.2	1.5	-1.2
Pavlov. Cond. lever latency	0.3	0.5	1.0	-0.5	-0.2	-1.0	0.8
Pavlov. Cond. magazine entry latency	0.7	0.8	1.7	-1.0	1.3	0.3	0.8
Pavlov. Cond. change in total contacts	0.3	0.5	1.3	0.4	0.2	1.1	-0.7
Pavlov. Cond. index score	0.2	0.3	0.6	-0.1	0.7	0.8	-0.1
Pavlov. Cond. latency score	0.2	0.2	0.3	0.3	0.3	0.6	-0.6
Pavlov. Cond. lever contacts	0.4	0.6	1.9	0.3	0.3	1.4	-0.6
Pavlov. Cond. magazine entry number	0.4	0.5	1.3	0.7	-1.1	-0.3	-0.5
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	-0.0	-0.1	0.1	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.8	-0.3	0.8	0.9	-0.0
Pavlov. Cond. response bias	0.4	0.6	1.6	-0.3	0.8	1.2	0.1
Conditioned reinforcement - actives	0.2	0.1	0.3	0.2	0.1	-0.5	-0.5
Conditioned reinforcement - inactives	2.8	3.1	11.7	0.5	-0.7	-3.4	-0.2
Conditioned locomotion	1.1	1.3	2.9	0.9	-1.0	-1.7	-0.7
Intermittent access intake day 1-15 change	3.2	3.2	4.3	-2.1	2.0	0.7	2.0
Intermittent access intake escalation	2.4	2.4	3.2	-1.8	1.7	0.7	1.7
Intermittent access intake escalation 2	1.3	1.3	1.7	-1.2	1.3	1.1	0.9
Intermitt. access day 1 inactive lever presses	1.3	1.4	2.0	-1.3	1.4	0.5	1.3
Intermitt. access day 15 inactive lever presses	1.8	2.0	3.0	-1.6	1.5	-0.7	1.7
Intermitt. access escalation Index	0.4	0.4	1.5	0.1	-0.3	-1.2	0.1
Intermittent access day 1 total infusions	2.5	2.9	4.3	1.8	-2.1	-1.4	-1.4
Intermittent access day 15 total infusions	0.2	0.2	0.5	0.4	-0.7	-0.5	-0.2
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	0.0	-0.3	0.1	0.1
Intermittent access total infusions	1.7	1.9	3.2	1.4	-1.8	-1.0	-1.2
Intermittent access day 1 locomotion	1.8	1.8	4.2	1.0	-1.3	-2.1	-0.5
Intermittent access day 15 total locomotion	1.4	1.5	4.2	0.7	-1.0	-2.1	-0.3
Intermittent access total locomotion	1.4	1.5	2.9	1.0	-1.3	-1.7	-0.8
Intermittent access standard deviation	1.2	1.3	1.8	-1.3	1.4	0.0	1.3
Cocaine induced anxiety	0.9	1.0	2.2	-0.6	1.5	1.2	0.2
Post-drug Anxiety	0.0	0.0	0.1	0.2	-0.0	0.2	-0.3
Baseline Anxiety	0.7	0.8	1.4	0.5	-1.2	-1.2	-0.2
Lifetime Intake	1.8	2.0	3.1	1.4	-1.8	-1.2	-1.2
Incentive Sensitization - Responses	1.3	1.3	2.1	1.0	-1.4	-1.0	-0.9
Incentive Sensitization - Breakpoint	1.7	1.7	2.8	1.3	-1.7	-0.9	-1.2
Progressive ratio test 1 active lever presses	0.4	0.4	1.0	0.4	-0.7	-1.0	-0.2
Progressive ratio test 1 breakpoint	0.2	0.2	0.4	0.2	-0.4	-0.6	-0.0
Progressive ratio test 1 inactive lever presses	1.1	1.2	2.1	-1.0	0.6	-1.4	1.2
Progressive ratio test 2 active lever presses	1.3	1.4	2.3	1.2	-1.5	-1.0	-1.0
Progressive ratio test 2 breakpoint	1.1	1.2	2.1	1.2	-1.4	-0.6	-1.1
Progressive ratio test 2 inactive lever presses	1.6	1.9	7.2	0.2	-0.5	-2.7	0.3
Total sessions with >9 infusions	2.0	2.2	7.6	0.5	-1.0	-2.8	-0.0
Short access day 1 total inactive lever presses	1.4	1.6	5.9	-0.1	-0.4	-2.4	0.5
Short access day 10 total inactive lever presses	1.0	1.0	1.6	-1.1	1.2	0.1	1.1
Short access day 1 total infusions	0.6	0.6	1.4	-0.6	0.2	-1.2	0.9
Short access day 10 total infusions	0.4	0.4	0.8	0.8	-0.9	-0.3	-0.6
Short access total infusions	1.0	1.1	2.7	0.7	-1.1	-1.6	-0.4
Short access day 1 locomotion	0.7	0.7	2.6	-0.2	0.2	-1.6	0.5
Short access day 10 total locomotion	0.7	0.7	1.9	0.7	-0.6	-1.4	-0.4
Short access total locomotion	0.9	0.9	3.3	0.2	-0.4	-1.8	0.2
Compulsive drug intake	0.2	0.1	0.4	-0.3	0.3	-0.6	0.3
One hour access (0.3 mA shock)	0.4	0.4	0.6	0.7	-0.5	-0.8	-0.7
One hour access (shock baseline)	0.4	0.5	0.9	0.8	-0.5	0.1	-1.0
Number of responses in last shaping day	0.7	0.7	2.2	-0.2	0.7	1.5	-0.0
Context. condit. distance diff. score	0.7	0.9	1.3	-1.0	1.1	0.3	1.1
Locomotion velocity, session 1	0.1	0.1	0.4	-0.2	-0.1	-0.6	0.3
Locomotion distance, session 1	2.4	3.1	5.2	-1.9	1.2	-1.5	2.3
Locomotion velocity, session 2	0.0	0.0	0.1	0.0	-0.1	-0.3	-0.1
Locomotion distance, session 2	3.1	4.5	7.9	-2.5	1.7	-1.0	2.8
Locomotion velocity, session 3	1.5	1.7	2.6	-1.5	1.4	0.1	1.6
Locomotion distance, session 3	2.5	2.7	3.7	-1.9	1.8	0.5	1.9
Stereotopy head waving bouts, day 3	0.5	0.5	1.0	0.9	-0.6	0.2	-1.0
Stereotopy head waving duration, day 3	1.1	1.4	2.6	1.4	-0.9	0.2	-1.6
Locomotion velocity, session 7	0.4	0.4	0.8	-0.6	0.1	-0.9	0.8
Locomotion distance, session 7	1.2	1.5	2.7	-1.5	0.9	-0.5	1.7
Stereotopy head waving bouts, day 7	0.3	0.4	0.5	0.7	-0.6	-0.3	-0.7
Stereotopy head waving duration, day 7	1.4	1.7	3.0	1.6	-1.2	-0.1	-1.7
Locomotion velocity, session 8	2.7	3.2	5.8	-2.1	1.5	-0.4	2.4
Locomotion distance, session 8	4.5	6.6	10.9	-3.0	2.5	0.1	3.3
Degree of sensitization distance	0.6	0.6	1.0	0.7	-1.0	-0.8	-0.6
Degree of sensitization stereotypy	0.2	0.2	0.4	0.6	-0.5	0.0	-0.6
Condit. Reinf. active minus inactive responses	1.7	1.9	2.9	-1.7	1.5	-0.1	1.7
Condit. Reinf. active-inactive response ratio	1.4	1.5	2.1	-1.2	1.4	1.4	0.9
Condit. Reinf. active responses	1.0	1.2	1.6	-1.2	1.0	-0.9	1.3
Condit. Reinf. inactive responses	1.2	1.4	4.9	-0.3	-0.1	-2.2	0.7
Incentive salience index mean	0.6	0.7	0.9	-0.9	0.7	-0.7	1.0
Condit. Reinf. lever presses	0.4	0.6	2.2	0.1	-0.4	-1.5	0.1
Time in familiar zone, hab. session 1	1.7	1.7	2.7	1.2	-1.6	-1.2	-1.0
Time in novel zone, hab. session 1	5.5	5.3	6.3	-2.3	2.5	2.3	2.1
Total zone transitions, hab. session 1	6.4	9.1	16.0	-3.5	2.5	-1.2	4.0
Total locomotion distance, hab. session 1	4.5	6.4	9.9	-3.0	2.6	-0.2	3.1
Locomotion velocity, hab. session 1	3.1	4.5	6.9	-2.5	2.1	-0.6	2.6
Time in familiar zone, hab. session 2	1.0	1.1	3.4	0.4	-0.8	-1.8	-0.1
Time in novel zone, hab. session 2	0.6	0.6	2.0	-0.2	0.5	1.4	-0.1
Total zone transitions, hab. session 2	3.1	3.9	6.7	-2.1	1.0	-1.9	2.6
Total locomotion distance, hab. session 2	0.9	1.2	1.7	-1.1	0.8	-1.0	1.3
Locomotion velocity, hab. session 2	0.7	1.0	1.4	-1.1	0.8	-0.8	1.2
Novel to familiar place preference ratio	0.1	0.2	0.3	-0.3	0.5	0.6	0.2
Novelty place preference	0.6	0.6	1.0	-0.7	0.9	1.0	0.5
Time in novel zone, NPP test	0.8	0.9	1.4	-0.8	1.0	1.2	0.6
Total zone transitions, NPP test	2.3	3.3	5.6	-2.1	1.7	-0.3	2.4
Total locomotion distance, NPP test	0.5	0.7	1.1	-0.9	1.0	-0.3	0.9
Locomotion velocity, NPP test	0.3	0.4	0.5	-0.6	0.7	-0.6	0.6
Pavlov. Cond. lever latency	2.0	2.5	7.6	-0.8	1.3	2.8	0.3
Pavlov. Cond. magazine entry latency	1.7	2.2	6.5	0.4	-1.4	-2.5	0.1
Pavlov. Cond. change in total contacts	0.4	0.4	1.2	-0.4	0.1	-1.1	0.6
Pavlov. Cond. index score	2.2	2.8	8.5	0.6	-1.5	-2.9	-0.1
Pavlov. Cond. latency score	2.5	3.2	9.1	0.9	-1.7	-3.0	-0.3
Pavlov. Cond. lever contacts	2.7	3.2	8.5	1.0	-1.7	-2.9	-0.5
Pavlov. Cond. magazine entry number	2.3	2.9	8.3	-0.8	1.6	2.9	0.3
Pavlov. Cond. intertrial magazine entries	2.9	3.4	4.8	-1.8	2.2	1.8	1.5
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.3	6.9	0.5	-1.4	-2.6	-0.0
Pavlov. Cond. response bias	2.2	2.7	7.7	0.7	-1.6	-2.8	-0.2
Bone: apparent density	0.3	0.5	0.9	0.7	0.1	0.7	-0.9
Bone surface	0.7	1.3	2.7	1.3	-0.4	0.8	-1.6
Bone volume	0.3	0.5	1.1	0.8	-0.0	0.6	-1.1
Bone: connectivity density	0.6	1.0	1.7	1.0	-0.1	1.1	-1.3
Bone: cortical apparent density	0.1	0.1	0.3	-0.4	0.1	0.2	0.5
Bone: cortical area	2.1	3.3	6.0	2.3	-1.4	-0.4	-2.4
Bone: cortical porosity	0.0	0.0	0.1	0.1	0.2	0.3	-0.2
Bone: cortical porosity	0.3	0.3	0.7	0.7	-0.3	0.2	-0.8
Bone: cortical thickness	0.4	0.7	1.3	1.1	-0.4	0.0	-1.1
Bone: cortical thickness	0.4	0.5	1.4	0.3	0.3	1.2	-0.6
Bone: cortical tissue density	0.1	0.1	0.2	-0.4	0.1	0.3	0.5
Bone: elastic displacement	0.5	0.5	1.1	0.0	-0.9	-1.0	0.4
Bone: elastic work	4.2	5.5	8.2	2.0	-2.7	-2.9	-1.5
Bone: endosteal estimation	3.1	6.7	11.2	3.1	-2.4	-0.1	-3.3
Bone: endosteal perimeter	2.5	5.1	7.4	2.6	-2.3	-0.9	-2.7
Bone: final force	1.7	2.7	5.1	2.0	-1.3	-0.3	-2.3
Bone: final moment	2.5	4.1	6.8	2.4	-1.8	-0.8	-2.6
Bone: marrow area	3.1	6.7	11.3	3.1	-2.4	0.0	-3.4
Bone: maximum diameter	2.5	4.5	7.6	2.6	-1.9	-0.5	-2.8
Bone: maximum force	2.2	3.9	6.7	2.4	-1.6	-0.6	-2.6
Bone: maximum moment	2.8	4.9	7.6	2.7	-1.9	-1.0	-2.8
Bone: minimum diameter	1.1	2.1	3.5	1.8	-1.2	-0.6	-1.9
Bone: periosteal estimation	3.4	7.0	12.3	3.2	-2.3	-0.3	-3.5
Bone: periosteal perimeter	4.5	7.5	11.5	3.3	-2.6	-1.1	-3.4
Bone: post-yield work	0.6	0.8	1.3	1.1	-0.8	0.1	-1.1
Bone: stiffness	0.3	0.4	0.6	0.4	0.6	0.8	-0.8
Bone: tissue strength	0.5	0.5	0.7	-0.7	0.6	-0.6	0.8
Bone: trabecular number	0.4	0.6	1.7	0.2	0.7	1.3	-0.5
Bone: trabecular spacing	0.7	0.9	1.5	0.9	-1.2	-0.6	-0.9
Bone: trabecular thickness	0.1	0.1	0.2	0.1	0.5	-0.1	-0.2
Bone: trabecular tissue density	4.8	6.8	9.9	-2.8	3.1	1.6	2.6
Breakpoint value in progressive ratio session	0.5	0.5	1.3	0.4	-0.8	-1.1	-0.2
Distance traveled before self-admin	0.2	0.2	0.4	0.3	-0.3	0.6	-0.6
Distance traveled after self-admin	0.1	0.1	0.2	-0.1	-0.0	0.5	-0.1
Delta time in closed arm before/after self-admin	2.3	2.2	5.1	-0.9	1.7	2.2	0.5
Delta time in open arm before/after self-admin	1.7	1.6	4.3	0.6	-1.4	-2.1	-0.2
Diff in mean of infusions in LGA sessions	0.8	0.9	3.3	-0.1	-0.5	-1.8	0.4
Extinction: sum of active levers before priming	0.2	0.2	0.4	-0.5	0.0	-0.4	0.6
Active lever presses in extinction session 6	0.3	0.3	0.7	-0.7	0.0	-0.4	0.8
Delta distance traveled before/after self-admin	0.1	0.1	0.3	-0.4	0.2	0.0	0.5
Delta ambulatory time before/after self-admin	0.3	0.3	0.7	-0.5	0.1	-0.5	0.8
Time in closed arm before self-admin	3.4	3.9	6.2	2.4	-1.9	-0.1	-2.5
Time in closed arm after self-admin	0.9	1.0	1.7	1.1	-0.2	1.0	-1.3
Time in open arm before self-admin	1.6	1.7	2.6	-1.1	1.5	1.6	0.8
Time in open arm after self-admin	0.7	0.8	2.1	-0.5	-0.3	-1.5	0.8
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	0.4	-0.6	-0.3	-0.5
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	0.3	-0.5	-0.6	-0.0
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.9	-0.1	0.3	0.9	-0.1
Time to tail flick, test, before self-admin	4.1	4.1	4.4	2.1	-2.1	-2.0	-1.9
Time to tail flick, test, after self-admin	0.5	0.5	0.8	0.7	-0.9	-0.5	-0.7
Delta time to tail flick, vehicle, before/after SA	0.9	0.8	2.7	-0.3	0.7	1.6	-0.1
Delta time to tail flick, test, before/after SA	1.0	0.9	1.3	-1.1	0.9	0.0	1.2
Ambulatory time before self-admin	0.0	0.0	0.1	-0.1	-0.1	0.3	-0.1
Ambulatory time after self-admin	0.1	0.1	0.3	0.2	-0.6	-0.1	-0.2
Total heroin consumption	0.7	0.8	2.3	0.5	-0.8	-1.5	-0.4
Area under the delay curve	0.1	0.1	0.4	-0.1	0.1	0.7	0.0
Delay disc. indifference point, 0s delay	1.6	1.8	3.9	-1.0	1.3	2.0	0.7
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	0.3	-0.2	-0.1	-0.3
Delay disc. indifference point, 2s delay	1.5	1.7	6.5	-0.2	0.5	2.5	-0.1
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	-0.2	0.1	0.0	0.2
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	-0.5	0.2	-0.3	0.6
Delay disc. indifference point, 8s delay	0.2	0.2	0.8	-0.1	0.2	0.9	-0.1
Delay discount exponential model param	0.1	0.1	0.2	0.1	-0.0	-0.4	-0.1
Delay discount hyperbolic model param	0.1	0.1	0.2	0.2	-0.0	-0.5	-0.1
Fecal boli incidents, locomotor time 1	1.1	1.2	3.9	-0.5	0.9	2.0	0.2
Change in fecal boli incidents, locomotor task	0.2	0.2	0.6	0.2	-0.4	-0.8	0.0
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.6	-0.1	0.8	0.6	-0.1
Bouts of movement, locomotor time 1	0.4	0.4	0.9	-0.5	0.1	-1.0	0.6
Total resting periods, locomotor time 1	0.2	0.2	0.3	-0.4	0.1	-0.5	0.5
Rest time, locomotor task time 1	0.5	0.6	1.3	-0.5	-0.1	-1.2	0.9
Distance moved, locomotor task time 1	0.5	0.5	1.1	0.4	0.2	1.1	-0.9
Vertical activity count, locomotor time 1	0.4	0.4	1.2	-0.1	0.7	1.1	-0.2
Time >=10cm from walls, locomotor time 2	1.1	1.2	2.7	0.8	-0.1	1.6	-1.2
Bouts of movement, locomotor time 2	1.6	1.8	4.7	0.7	-1.4	-2.2	-0.1
Total resting periods, locomotor time 2	1.8	1.9	5.4	0.6	-1.4	-2.3	-0.1
Rest time, locomotor task time 2	1.3	1.5	5.6	0.0	-0.5	-2.4	0.4
Distance moved, locomotor task time 2	0.2	0.3	0.8	-0.2	0.6	0.9	-0.1
Vertical activity count, locomotor time 2	0.3	0.3	0.8	0.3	0.1	0.9	-0.5
Weight adjusted by age	1.8	2.0	3.3	1.4	-0.8	1.4	-1.8
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	0.3	-0.4	-0.4	-0.3
Locomotion in novel chamber	1.3	1.6	2.5	1.4	-1.6	-0.1	-1.4
Locomotion in novel chamber post-restriction	1.5	1.8	5.4	0.3	-1.2	-2.3	0.4
Progressive ratio	2.3	2.6	4.7	1.1	-2.1	-2.2	-0.4
Food seeking constrained by brief footshock	6.5	7.9	12.2	2.8	-1.9	2.8	-3.5
Seeking ratio, punishment vs. effort	2.8	3.5	11.5	0.4	0.6	3.4	-1.4
Run reversals in cocaine runway, females	0.4	0.4	0.7	0.7	-0.6	0.1	-0.8
Run reversals in cocaine runway, males	0.5	0.5	0.7	-0.8	0.8	-0.1	0.8
Latency to leave start box in cocaine runway	0.9	1.0	1.6	1.1	-1.0	0.5	-1.2
Latency to leave start box in cocaine runway, F	0.4	0.5	0.9	0.7	-0.5	0.3	-0.9
Latency to leave start box in cocaine runway, M	0.6	0.6	1.2	0.6	-0.5	1.1	-0.7
Cd content in liver	0.3	0.3	0.4	0.6	-0.5	0.5	-0.6
Co content in liver	0.5	0.6	1.1	0.6	-0.6	1.1	-0.7
Cu content in liver	0.4	0.5	0.6	-0.8	0.8	0.6	0.6
Fe content in liver	0.1	0.1	0.2	0.4	-0.4	-0.2	-0.4
K content in liver	1.8	1.8	2.4	-1.6	1.4	0.8	1.5
Mg content in liver	0.3	0.3	0.4	-0.6	0.6	0.6	0.4
Mn content in liver	0.0	0.0	0.1	0.2	0.0	-0.2	-0.2
Na content in liver	2.5	2.7	3.3	-1.8	1.8	1.1	1.7
Rb content in liver	1.2	1.4	2.4	-1.0	1.3	1.5	0.8
Se content in liver	4.9	5.9	7.6	-2.4	2.8	2.5	2.0
Sr content in liver	3.9	3.6	4.9	-2.2	2.0	0.7	2.2
Zn content in liver	0.4	0.4	0.9	0.5	-0.4	0.9	-0.7