Hub : Genes

ENSRNOG00000066318

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000066318 0.02 0.01 7.6e-03 0.01 0.01 0 0.01 1.7e-02 1.1e-02 1.2e-01 2.3e-02
2 BLA gene expression ENSRNOG00000066318 0.24 0.12 3.8e-14 0.2 0.2 0.2 0.04 8.5e-11 3.9e-11 4.7e-11 1.9e-03
3 BLA intron excision ratio chr3:117617434:117617729 0.05 0.04 9.0e-03 0.01 0.01 0.01 0.01 7.9e-02 1.0e-01 9.2e-02 1.4e-01
4 Brain gene expression ENSRNOG00000066318 0.19 0.13 0.0e+00 0.18 0.18 0.18 0.18 2.2e-16 1.3e-16 5.9e-17 8.5e-17
5 Brain mRNA stability ENSRNOG00000066318 0.06 0.04 1.1e-06 0.06 0.06 0.06 0.06 2.9e-06 1.3e-06 6.6e-06 4.5e-06
6 IL gene expression ENSRNOG00000066318 0.16 0.12 6.0e-03 0.07 0.02 0.04 0.03 8.6e-03 8.9e-02 3.8e-02 5.9e-02
7 NAcc gene expression ENSRNOG00000066318 0.17 0.1 5.7e-15 0.19 0.2 0.2 0.2 6.1e-14 1.8e-14 1.1e-14 1.4e-14
8 OFC gene expression ENSRNOG00000066318 0.37 0.17 6.1e-08 0.32 0.29 0.28 0.29 3.1e-08 1.0e-07 2.9e-07 1.3e-07
9 PL gene expression ENSRNOG00000066318 0.48 0.26 0.0e+00 0.31 0.31 0.31 0.32 5.0e-24 3.1e-24 5.6e-24 1.9e-24

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
BMI with tail1.13.65.11.91.9-1.32.31.91.91.91.92.0
BMI without tail3.77.710.02.82.8-2.03.22.82.82.72.83.0
Body weight5.924.927.85.15.1-3.75.35.05.15.15.15.2
Epididymis fat weight1.43.23.61.81.8-1.41.91.81.81.91.91.8
Glucose0.40.62.10.60.7-1.40.60.50.70.80.60.7
Heart weight3.55.09.12.02.2-3.02.11.82.22.42.12.1
Left kidney weight1.02.94.81.51.7-2.21.71.41.51.81.61.7
Right kidney weight1.02.96.01.51.6-2.51.61.31.51.91.51.7
Tail length4.814.617.33.93.9-2.54.13.93.93.83.94.2
Length with tail4.717.218.94.24.3-3.64.24.14.14.34.24.3
Length without tail1.43.03.31.71.8-1.71.61.71.71.81.71.7
Liver weight, left0.10.20.6-0.4-0.2-0.7-0.4-0.5-0.3-0.1-0.4-0.1
Liver weight, right0.10.10.50.20.10.70.50.20.2-0.00.00.3
Parametrial fat weight0.10.20.3-0.4-0.50.50.0-0.4-0.3-0.4-0.5-0.3
Retroperitoneal fat weight0.00.10.4-0.2-0.30.70.3-0.3-0.2-0.2-0.3-0.1
Intraocular pressure0.00.00.10.20.10.30.00.20.10.10.20.2
Extensor digitorum longus weight0.10.20.30.50.50.00.50.50.50.50.50.5
Soleus weight0.00.10.40.10.2-0.60.10.00.20.40.10.2
Tibialis anterior weight0.82.63.01.71.7-0.91.71.71.61.71.71.7
Tibia length4.412.514.43.73.6-2.13.83.73.73.53.73.8
Number of licking bursts0.30.41.7-0.4-0.51.3-0.4-0.2-0.3-0.7-0.5-0.4
Food consumed during 24 hour testing period0.70.91.2-1.0-1.0-0.2-1.0-1.1-1.0-0.9-1.1-0.9
Times rat made contact with spout0.10.10.7-0.1-0.0-0.9-0.2-0.2-0.10.1-0.2-0.1
Mean time between licks in bursts0.00.00.1-0.0-0.10.30.2-0.0-0.0-0.1-0.10.0
Mean num. licks in bursts0.40.53.40.30.5-1.80.30.10.30.70.30.3
Std. dev. time between licks in bursts0.40.50.70.70.7-0.80.90.60.70.80.50.8
Water consumed over 24 hours0.10.10.2-0.3-0.30.1-0.4-0.2-0.2-0.4-0.3-0.2
Indifference point 0 sec0.40.64.70.30.5-2.2-0.10.10.30.70.40.2
Indifference point AUC0.50.60.90.80.8-0.50.90.80.70.80.90.8
Indifference point function ln k0.10.10.30.20.3-0.50.30.10.30.40.20.2
Indifference point function log k0.10.10.30.20.3-0.50.30.10.30.40.20.2
Delay discounting total patch changes 0 sec0.40.74.90.30.5-2.2-0.00.10.30.70.40.3
Delay discounting total patch changes 12 sec0.50.71.80.70.7-1.30.80.70.70.90.70.8
Delay discounting total patch changes 18 sec0.60.81.1-1.0-0.9-0.2-1.0-1.1-1.0-0.6-1.0-0.9
Delay discounting total patch changes 24 sec1.31.72.4-1.4-1.2-0.1-1.6-1.5-1.4-1.1-1.3-1.4
Delay discounting total patch changes 6 sec0.91.47.40.70.9-2.70.50.60.81.20.80.7
Delay discounting time to switch 0 sec2.13.35.1-1.7-1.92.3-1.5-1.5-1.8-1.9-1.9-1.6
Delay discounting water rate 0 sec4.67.214.32.52.8-3.82.12.22.72.72.72.4
Delay discounting water rate 12 sec0.10.21.20.20.3-1.1-0.20.10.20.40.40.0
Delay discounting water rate 18 sec0.40.51.10.70.7-1.10.50.60.70.60.80.6
Delay discounting water rate 24 sec0.50.70.90.90.9-0.40.70.90.90.60.90.8
Delay discounting water rate 6 sec2.02.83.41.81.8-1.21.51.71.71.71.81.8
Locomotor activity0.10.20.30.50.5-0.50.40.60.50.30.40.3
Locomotor testing distance0.10.20.5-0.3-0.3-0.4-0.7-0.3-0.3-0.5-0.4-0.6
Locomotor testing rearing0.30.52.50.60.7-1.60.20.50.60.60.60.4
Light reinforcement 10.91.72.11.41.4-0.81.21.51.31.31.31.3
Light reinforcement 20.70.91.11.01.0-0.40.91.00.91.01.11.0
Reaction time number correct0.40.51.40.60.8-1.20.20.60.50.70.90.4
Reaction time mean minus median0.71.01.5-1.0-1.00.6-1.2-1.0-0.9-1.0-1.1-1.0
Reaction time mean minus median AUC0.50.61.2-0.8-0.70.3-1.1-0.8-0.7-0.7-0.9-0.9
Reaction time num false alarms2.02.74.31.51.7-2.11.61.41.51.71.61.5
Reaction time num false alarms AUC2.02.83.11.71.7-1.71.81.61.61.71.71.6
Reaction time trials correct on left0.40.51.40.60.8-1.20.20.60.50.70.90.4
Reaction time trials on left0.40.61.50.70.8-1.20.30.60.60.81.00.5
Reaction time mean0.00.00.1-0.1-0.10.4-0.1-0.0-0.0-0.1-0.2-0.0
Reaction time mean AUC0.00.00.1-0.2-0.20.3-0.2-0.1-0.1-0.1-0.3-0.1
Median of all reaction times0.00.00.10.20.20.10.20.20.20.20.10.3
Reaction time omissions0.50.61.80.70.8-1.30.50.60.80.90.60.7
Reaction time false alarm rate0.91.31.91.11.1-1.11.41.11.11.21.01.2
Reaction time premature initiation rate0.20.30.9-0.4-0.41.0-0.6-0.3-0.5-0.6-0.3-0.6
Reaction time premature initiations0.10.10.3-0.1-0.20.3-0.5-0.1-0.3-0.30.0-0.5
Std. dev. reaction times0.10.10.20.40.30.30.30.50.50.20.30.3
Reaction time trials completed0.40.61.50.70.8-1.20.30.60.60.81.00.5
Reaction time trials AUC0.50.71.70.80.9-1.30.30.70.60.81.00.5
Social response proportion2.12.35.41.31.5-2.31.11.21.41.71.31.4
Social responses5.16.67.22.62.6-2.42.52.52.72.72.52.6
Social time0.50.61.00.80.8-0.40.80.80.90.90.71.0
Conditioned locomotion4.45.37.32.22.3-2.72.22.02.22.52.12.3
Cocaine response after cond. corrected0.10.10.2-0.4-0.3-0.1-0.4-0.5-0.4-0.3-0.4-0.4
Cocaine response after cond. not corrected0.20.20.3-0.5-0.50.3-0.5-0.5-0.5-0.5-0.5-0.6
Cocaine response before conditioning0.20.20.5-0.3-0.40.7-0.6-0.3-0.4-0.5-0.3-0.4
Saline control response7.29.610.73.13.2-2.73.33.03.23.23.03.2
Condit. Reinf. active minus inactive responses2.43.03.51.71.9-1.91.41.61.81.81.81.7
Condit. Reinf. active-inactive response ratio2.42.52.81.61.7-1.51.41.51.71.61.61.5
Condit. Reinf. active responses3.95.46.32.32.5-2.51.92.22.42.52.42.2
Condit. Reinf. inactive responses0.91.12.50.91.0-1.60.70.80.91.11.00.9
Condit. Reinf. lever presses1.52.02.41.51.5-1.01.21.51.51.31.61.4
Condit. Reinf. lever reinforcers received3.14.35.82.02.2-2.41.61.92.12.22.21.9
Pavlov. Cond. lever latency4.05.56.2-2.5-2.41.5-2.3-2.5-2.5-2.3-2.4-2.5
Pavlov. Cond. magazine entry latency0.20.21.40.30.3-1.20.10.20.30.40.30.3
Pavlov. Cond. change in total contacts3.95.46.22.52.4-1.52.32.52.52.22.52.4
Pavlov. Cond. index score3.34.34.82.22.2-1.72.02.12.22.12.12.1
Pavlov. Cond. latency score2.63.33.51.91.9-1.61.71.81.91.81.81.9
Pavlov. Cond. lever contacts3.95.56.12.42.4-1.72.32.42.42.32.42.5
Pavlov. Cond. magazine entry number0.70.81.1-0.9-0.91.1-0.7-0.9-0.9-0.9-0.9-0.8
Pavlov. Cond. intertrial magazine entries1.11.41.5-1.2-1.21.0-1.1-1.2-1.2-1.1-1.1-1.2
Pavlov. Cond. lever-magazine prob. diff.3.03.84.22.02.0-1.71.92.02.01.92.02.0
Pavlov. Cond. response bias4.35.96.52.52.5-2.02.32.52.52.52.52.5
Conditioned reinforcement - actives0.00.00.20.10.1-0.4-0.10.10.10.10.00.2
Conditioned reinforcement - inactives0.60.73.70.50.7-1.90.20.40.60.90.50.4
Conditioned locomotion0.10.10.1-0.3-0.3-0.1-0.3-0.3-0.3-0.2-0.4-0.2
Intermittent access intake day 1-15 change0.50.51.00.60.7-1.00.60.50.70.70.50.7
Intermittent access intake escalation0.10.10.30.30.4-0.50.20.30.40.30.30.3
Intermittent access intake escalation 20.20.20.3-0.5-0.50.1-0.4-0.5-0.5-0.4-0.5-0.5
Intermitt. access day 1 inactive lever presses0.30.30.7-0.5-0.3-0.6-0.8-0.5-0.5-0.2-0.4-0.6
Intermitt. access day 15 inactive lever presses0.20.21.2-0.2-0.0-1.1-0.3-0.3-0.10.1-0.2-0.1
Intermitt. access escalation Index0.10.10.8-0.0-0.10.90.20.00.0-0.3-0.0-0.0
Intermittent access day 1 total infusions0.10.10.3-0.3-0.40.50.0-0.3-0.3-0.3-0.4-0.1
Intermittent access day 15 total infusions0.00.00.10.00.1-0.40.1-0.00.10.2-0.00.2
Intermittent access terminal intake (last 3 days)0.00.00.3-0.1-0.0-0.50.0-0.2-0.10.1-0.10.1
Intermittent access total infusions0.00.00.1-0.2-0.2-0.2-0.0-0.3-0.2-0.1-0.3-0.0
Intermittent access day 1 locomotion0.10.10.2-0.3-0.30.2-0.5-0.4-0.3-0.3-0.4-0.4
Intermittent access day 15 total locomotion0.20.31.4-0.4-0.2-1.2-0.4-0.5-0.40.1-0.4-0.3
Intermittent access total locomotion0.10.10.2-0.4-0.3-0.3-0.3-0.5-0.4-0.2-0.5-0.3
Intermittent access standard deviation0.10.10.10.30.30.00.20.30.30.20.20.3
Cocaine induced anxiety5.15.87.9-2.5-2.41.0-2.8-2.6-2.4-2.4-2.4-2.7
Post-drug Anxiety1.51.72.8-1.3-1.30.4-1.7-1.4-1.3-1.3-1.3-1.4
Baseline Anxiety0.60.60.90.80.8-0.50.80.90.80.80.80.9
Lifetime Intake0.10.10.30.20.3-0.40.50.20.30.30.20.5
Incentive Sensitization - Responses0.20.20.50.30.3-0.60.70.20.20.50.30.5
Incentive Sensitization - Breakpoint0.10.10.30.10.1-0.60.50.0-0.00.30.10.3
Progressive ratio test 1 active lever presses2.42.53.81.61.6-1.11.91.61.61.61.41.8
Progressive ratio test 1 breakpoint3.23.34.71.81.8-1.32.21.81.81.81.62.0
Progressive ratio test 1 inactive lever presses0.30.31.00.40.6-1.00.30.30.40.60.40.5
Progressive ratio test 2 active lever presses0.30.31.20.30.4-1.10.60.20.20.60.20.5
Progressive ratio test 2 breakpoint0.20.20.80.30.3-0.90.60.20.20.50.20.5
Progressive ratio test 2 inactive lever presses0.30.32.00.20.4-1.40.10.10.30.60.30.3
Total sessions with >9 infusions0.40.40.90.70.6-0.10.90.70.70.50.60.9
Short access day 1 total inactive lever presses0.70.81.0-0.8-0.90.8-0.9-0.8-1.0-0.9-0.9-0.9
Short access day 10 total inactive lever presses3.63.95.3-2.1-1.90.1-2.3-2.3-2.1-1.7-2.1-2.1
Short access day 1 total infusions0.00.00.10.00.00.00.30.00.00.0-0.00.2
Short access day 10 total infusions0.00.00.20.0-0.00.40.30.00.0-0.1-0.10.3
Short access total infusions0.30.30.70.50.5-0.10.80.50.60.40.40.8
Short access day 1 locomotion0.91.01.5-1.1-1.0-0.2-1.1-1.2-1.1-0.8-1.2-1.0
Short access day 10 total locomotion0.00.00.00.10.1-0.1-0.00.10.10.10.10.1
Short access total locomotion0.00.00.20.00.1-0.5-0.1-0.00.10.1-0.00.1
Compulsive drug intake4.14.14.6-2.0-2.11.8-2.2-1.9-2.0-2.1-2.1-2.0
One hour access (0.3 mA shock)0.10.10.6-0.2-0.2-0.7-0.3-0.3-0.2-0.1-0.2-0.1
One hour access (shock baseline)0.50.51.60.60.7-1.30.60.40.60.70.60.8
Number of responses in last shaping day0.20.20.3-0.4-0.40.3-0.6-0.4-0.4-0.4-0.5-0.5
Context. condit. distance diff. score0.10.11.00.00.2-1.00.1-0.10.00.40.10.2
Locomotion velocity, session 10.30.30.40.60.6-0.60.50.50.60.60.60.6
Locomotion distance, session 10.40.63.30.40.6-1.80.40.10.40.80.40.5
Locomotion velocity, session 20.10.10.2-0.3-0.3-0.1-0.4-0.4-0.4-0.3-0.3-0.4
Locomotion distance, session 21.31.95.21.11.4-2.31.10.91.11.61.21.3
Locomotion velocity, session 31.21.41.81.21.2-0.81.31.21.21.21.21.2
Locomotion distance, session 36.47.08.62.72.7-2.02.92.62.62.72.72.8
Stereotopy head waving bouts, day 31.11.32.5-1.2-1.0-0.2-1.6-1.3-1.1-0.9-1.1-1.3
Stereotopy head waving duration, day 30.70.81.6-0.9-0.80.3-1.3-1.0-0.9-0.9-0.9-1.1
Locomotion velocity, session 70.80.91.21.01.0-0.80.90.90.91.11.00.9
Locomotion distance, session 70.60.71.50.70.8-1.20.80.60.71.10.70.8
Stereotopy head waving bouts, day 70.50.60.70.80.8-0.40.70.90.90.60.80.7
Stereotopy head waving duration, day 70.20.20.30.50.4-0.10.40.50.60.30.50.4
Locomotion velocity, session 80.50.63.10.50.7-1.80.40.30.50.90.50.6
Locomotion distance, session 82.33.410.21.41.8-3.21.51.11.42.21.41.7
Degree of sensitization distance2.12.22.9-1.6-1.50.8-1.7-1.6-1.6-1.3-1.5-1.6
Degree of sensitization stereotypy2.42.63.41.81.7-0.51.81.81.81.41.71.7
Condit. Reinf. active minus inactive responses0.70.71.20.90.9-0.21.11.00.90.80.90.8
Condit. Reinf. active-inactive response ratio0.70.80.80.90.9-0.80.90.90.90.90.90.8
Condit. Reinf. active responses0.50.61.10.80.80.01.00.90.80.70.80.8
Condit. Reinf. inactive responses0.00.00.0-0.00.00.10.1-0.0-0.00.1-0.00.1
Incentive salience index mean0.40.50.90.70.7-0.31.00.80.70.60.70.7
Condit. Reinf. lever presses0.10.10.30.30.2-0.00.60.30.30.20.30.3
Time in familiar zone, hab. session 11.41.31.5-1.2-1.20.9-1.2-1.2-1.2-1.1-1.2-1.2
Time in novel zone, hab. session 10.50.50.90.70.7-1.00.70.60.70.70.60.7
Total zone transitions, hab. session 10.10.20.60.20.4-0.80.40.10.20.50.30.3
Total locomotion distance, hab. session 10.10.10.8-0.00.1-0.9-0.1-0.1-0.10.30.00.0
Locomotion velocity, hab. session 10.10.10.90.10.3-0.90.10.00.10.40.20.2
Time in familiar zone, hab. session 21.61.71.9-1.4-1.30.7-1.4-1.4-1.3-1.3-1.4-1.3
Time in novel zone, hab. session 21.71.71.91.41.3-0.71.41.41.41.31.31.3
Total zone transitions, hab. session 22.32.93.61.71.8-1.31.91.71.71.81.71.8
Total locomotion distance, hab. session 20.70.92.50.81.0-1.60.70.60.81.20.80.9
Locomotion velocity, hab. session 20.30.52.10.40.6-1.50.40.20.40.80.50.5
Novel to familiar place preference ratio0.20.20.3-0.5-0.4-0.2-0.5-0.6-0.4-0.3-0.5-0.3
Novelty place preference0.30.40.6-0.7-0.6-0.1-0.7-0.8-0.6-0.5-0.7-0.5
Time in novel zone, NPP test0.20.20.3-0.5-0.4-0.1-0.5-0.6-0.4-0.3-0.5-0.4
Total zone transitions, NPP test0.10.10.30.30.30.00.50.40.30.30.30.4
Total locomotion distance, NPP test0.20.31.50.30.5-1.20.30.20.30.70.40.4
Locomotion velocity, NPP test0.10.10.9-0.00.1-0.9-0.1-0.2-0.10.30.0-0.0
Pavlov. Cond. lever latency0.20.30.60.70.60.20.30.70.70.40.70.5
Pavlov. Cond. magazine entry latency0.00.00.10.20.2-0.20.20.20.20.30.20.2
Pavlov. Cond. change in total contacts0.00.00.10.10.2-0.20.20.10.10.20.10.1
Pavlov. Cond. index score0.00.00.0-0.1-0.1-0.10.1-0.1-0.2-0.0-0.1-0.0
Pavlov. Cond. latency score0.10.10.2-0.4-0.3-0.0-0.1-0.4-0.4-0.2-0.4-0.3
Pavlov. Cond. lever contacts0.00.10.20.10.1-0.50.40.00.00.20.10.2
Pavlov. Cond. magazine entry number0.50.71.0-0.9-0.8-0.1-1.0-0.9-0.8-0.7-0.9-0.9
Pavlov. Cond. intertrial magazine entries0.10.10.40.30.4-0.60.20.20.30.40.30.3
Pavlov. Cond. lever-magazine prob. diff.0.00.00.0-0.1-0.10.10.1-0.1-0.2-0.1-0.1-0.0
Pavlov. Cond. response bias0.30.40.70.70.6-0.40.80.60.60.70.60.7
Bone: apparent density0.50.83.00.70.8-1.70.70.50.71.00.70.7
Bone surface0.81.43.61.01.1-1.91.10.91.01.31.01.1
Bone volume0.81.33.11.01.1-1.81.00.81.01.21.01.0
Bone: connectivity density0.30.42.30.40.5-1.50.30.30.40.60.40.4
Bone: cortical apparent density0.70.91.31.00.90.51.11.21.00.71.00.9
Bone: cortical area3.35.16.22.32.3-1.82.52.22.32.32.32.3
Bone: cortical porosity0.30.31.10.40.21.10.70.60.30.10.30.4
Bone: cortical porosity0.60.61.20.80.60.71.11.00.70.50.70.8
Bone: cortical thickness1.42.43.31.61.6-0.91.81.61.61.51.61.6
Bone: cortical thickness0.30.30.50.60.6-0.20.70.70.60.50.70.6
Bone: cortical tissue density0.50.71.10.90.80.50.91.00.90.60.80.8
Bone: elastic displacement0.20.21.80.1-0.11.30.10.2-0.0-0.30.10.0
Bone: elastic work0.10.10.50.20.10.70.30.30.2-0.00.20.2
Bone: endosteal estimation0.51.11.41.01.1-1.21.10.91.01.11.01.1
Bone: endosteal perimeter2.34.75.12.12.2-2.22.22.02.22.32.12.2
Bone: final force3.65.97.22.42.5-1.92.72.42.52.42.42.5
Bone: final moment2.74.55.72.12.2-1.72.42.12.22.12.12.2
Bone: marrow area0.51.01.40.91.0-1.21.00.91.01.11.01.0
Bone: maximum diameter4.68.49.22.82.9-2.73.02.72.93.02.93.0
Bone: maximum force0.71.21.41.11.1-1.01.21.01.11.11.01.1
Bone: maximum moment0.30.50.60.70.7-0.70.80.60.70.70.60.7
Bone: minimum diameter1.63.03.71.71.7-1.71.91.61.71.81.71.8
Bone: periosteal estimation2.44.95.62.22.3-1.92.42.12.22.32.22.3
Bone: periosteal perimeter3.45.76.32.32.4-2.52.52.22.42.52.32.4
Bone: post-yield work0.60.81.0-0.9-0.90.4-1.0-0.9-0.8-0.9-0.9-0.9
Bone: stiffness1.82.93.51.71.7-1.51.91.61.71.71.61.8
Bone: tissue strength0.10.10.20.40.4-0.30.30.40.40.40.40.4
Bone: trabecular number0.71.01.41.01.1-1.21.00.91.01.11.01.0
Bone: trabecular spacing0.10.20.7-0.3-0.40.8-0.4-0.2-0.3-0.4-0.3-0.3
Bone: trabecular thickness0.40.51.40.60.7-1.20.70.50.60.70.60.6
Bone: trabecular tissue density1.52.02.51.41.4-1.31.61.31.41.61.41.4
Breakpoint value in progressive ratio session2.83.14.21.91.8-0.42.01.91.91.71.81.9
Distance traveled before self-admin5.25.56.42.22.4-2.52.42.12.42.52.12.5
Distance traveled after self-admin3.23.54.71.81.9-2.01.81.61.82.21.62.1
Delta time in closed arm before/after self-admin0.30.30.4-0.5-0.50.5-0.4-0.5-0.5-0.7-0.4-0.6
Delta time in open arm before/after self-admin1.31.25.50.71.0-2.30.50.50.71.20.71.0
Diff in mean of infusions in LGA sessions0.10.11.1-0.1-0.21.00.1-0.1-0.1-0.2-0.1-0.2
Extinction: sum of active levers before priming0.70.70.90.90.90.10.80.91.00.80.90.9
Active lever presses in extinction session 60.10.10.4-0.4-0.4-0.1-0.2-0.5-0.3-0.4-0.6-0.1
Delta distance traveled before/after self-admin0.20.20.40.50.4-0.00.50.50.40.70.50.5
Delta ambulatory time before/after self-admin0.60.61.4-0.7-0.81.2-0.6-0.6-0.8-0.6-0.8-0.7
Time in closed arm before self-admin0.20.30.4-0.5-0.50.5-0.4-0.5-0.6-0.6-0.6-0.4
Time in closed arm after self-admin0.70.71.1-0.8-0.91.1-0.5-0.7-0.9-1.0-0.7-0.8
Time in open arm before self-admin0.30.31.3-0.4-0.51.1-0.3-0.3-0.3-0.5-0.4-0.6
Time in open arm after self-admin0.30.31.90.30.4-1.4-0.00.10.30.70.20.5
Sum of active levers in priming session hrs 5-61.21.11.41.11.2-0.90.91.01.21.21.21.0
Time to tail flick, vehicle, before self-admin2.02.02.7-1.5-1.40.1-1.6-1.6-1.5-1.4-1.4-1.5
Time to tail flick, vehicle, after self-admin0.00.00.2-0.0-0.10.50.00.0-0.0-0.3-0.1-0.0
Time to tail flick, test, before self-admin1.01.01.51.11.0-0.01.11.21.10.91.20.9
Time to tail flick, test, after self-admin2.12.22.9-1.6-1.50.6-1.7-1.6-1.5-1.4-1.5-1.6
Delta time to tail flick, vehicle, before/after SA3.33.24.01.91.9-0.92.01.92.01.71.81.9
Delta time to tail flick, test, before/after SA2.72.44.0-1.7-1.5-0.0-2.0-1.8-1.6-1.4-1.6-1.6
Ambulatory time before self-admin4.54.75.32.12.1-2.32.22.02.22.32.02.3
Ambulatory time after self-admin3.94.35.52.02.1-2.02.11.92.02.41.82.3
Total heroin consumption3.54.14.72.12.2-1.22.12.12.22.12.22.0
Area under the delay curve0.40.41.7-0.5-0.61.3-0.4-0.3-0.5-0.6-0.5-0.6
Delay disc. indifference point, 0s delay3.23.58.4-1.7-1.82.9-1.6-1.6-1.8-1.8-1.8-1.6
Delay disc. indifference point, 16s delay0.80.81.4-0.8-0.91.2-0.7-0.7-0.8-1.0-0.8-1.0
Delay disc. indifference point, 2s delay0.10.10.6-0.1-0.10.8-0.1-0.1-0.1-0.1-0.1-0.3
Delay disc. indifference point, 24s delay2.72.63.4-1.6-1.71.5-1.5-1.5-1.6-1.9-1.6-1.8
Delay disc. indifference point, 4s delay0.10.10.70.20.10.80.30.30.2-0.00.20.1
Delay disc. indifference point, 8s delay0.40.41.8-0.4-0.61.3-0.4-0.3-0.5-0.7-0.5-0.6
Delay discount exponential model param0.30.41.40.40.5-1.20.40.30.40.60.40.6
Delay discount hyperbolic model param0.30.31.40.40.5-1.20.30.30.40.60.40.6
Fecal boli incidents, locomotor time 10.10.10.20.30.30.20.30.30.30.30.20.4
Change in fecal boli incidents, locomotor task0.10.10.2-0.3-0.3-0.3-0.4-0.3-0.3-0.2-0.3-0.4
Time >=10cm from walls, locomotor time 10.10.10.10.30.2-0.00.30.30.30.20.40.2
Bouts of movement, locomotor time 12.32.63.6-1.6-1.71.9-1.3-1.5-1.6-1.8-1.7-1.4
Total resting periods, locomotor time 11.92.13.7-1.3-1.51.9-1.2-1.2-1.3-1.6-1.5-1.3
Rest time, locomotor task time 10.20.30.5-0.4-0.50.7-0.5-0.4-0.5-0.6-0.5-0.5
Distance moved, locomotor task time 10.10.10.90.10.2-0.90.10.00.20.30.20.1
Vertical activity count, locomotor time 10.40.53.10.30.4-1.80.50.20.30.60.30.3
Time >=10cm from walls, locomotor time 20.00.00.0-0.1-0.1-0.20.1-0.0-0.1-0.10.00.1
Bouts of movement, locomotor time 20.70.71.5-0.7-0.91.2-0.6-0.6-0.7-1.0-0.9-0.7
Total resting periods, locomotor time 20.70.82.2-0.7-0.81.5-0.6-0.5-0.7-1.0-0.9-0.7
Rest time, locomotor task time 20.50.51.8-0.4-0.61.4-0.9-0.3-0.5-0.8-0.4-0.7
Distance moved, locomotor task time 20.20.21.8-0.2-0.1-1.40.1-0.4-0.20.2-0.20.1
Vertical activity count, locomotor time 20.60.75.10.20.4-2.30.5-0.00.30.70.30.4
Weight adjusted by age3.74.15.62.12.2-1.41.92.02.32.41.92.1
Seeking ratio, delayed vs. immediate footshock0.20.30.5-0.5-0.50.7-0.5-0.5-0.3-0.5-0.6-0.5
Locomotion in novel chamber0.10.20.4-0.3-0.30.6-0.4-0.3-0.4-0.5-0.3-0.4
Locomotion in novel chamber post-restriction1.01.21.81.21.2-0.91.01.21.11.11.41.0
Progressive ratio2.63.03.5-1.7-1.81.6-1.8-1.6-1.7-1.9-1.8-1.7
Food seeking constrained by brief footshock0.50.62.90.40.6-1.70.50.20.40.80.60.3
Seeking ratio, punishment vs. effort2.93.65.81.81.9-2.41.91.61.72.11.91.6
Run reversals in cocaine runway, females0.10.10.7-0.10.1-0.8-0.3-0.10.10.10.1-0.2
Run reversals in cocaine runway, males1.01.01.80.91.0-1.30.90.80.91.10.90.9
Latency to leave start box in cocaine runway0.60.60.8-0.8-0.90.9-0.4-0.8-0.9-0.8-0.8-0.7
Latency to leave start box in cocaine runway, F1.31.51.7-1.3-1.31.1-0.9-1.2-1.3-1.3-1.3-1.1
Latency to leave start box in cocaine runway, M0.10.10.20.20.3-0.40.30.20.20.30.30.3
Cd content in liver0.10.10.2-0.4-0.4-0.0-0.3-0.3-0.4-0.3-0.4-0.4
Co content in liver0.70.91.10.91.0-0.80.90.90.91.00.90.9
Cu content in liver2.12.63.01.61.7-1.61.51.51.61.71.61.6
Fe content in liver0.10.10.6-0.10.0-0.8-0.2-0.10.00.1-0.00.0
K content in liver0.20.20.50.50.5-0.30.70.50.50.50.50.5
Mg content in liver1.71.72.01.31.3-1.31.41.21.31.41.31.3
Mn content in liver1.82.12.61.51.5-1.01.61.51.51.51.51.5
Na content in liver0.10.10.1-0.3-0.20.2-0.1-0.3-0.2-0.3-0.4-0.1
Rb content in liver4.15.210.32.02.3-3.22.01.82.12.52.12.1
Se content in liver0.81.01.31.01.0-1.20.80.91.01.10.91.0
Sr content in liver0.50.40.60.70.7-0.10.70.70.70.60.60.7
Zn content in liver0.20.30.40.40.5-0.60.60.40.50.50.50.5