| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | mRNA stability | ENSRNOG00000009460 | 0.0350 | 0.0220 | 2.3e-03 | 0.000 | 0.005 | 0.003 | -0.001 | 3.0e-01 | 7.6e-02 | 1.3e-01 | 4.1e-01 |
| 2 | Brain | mRNA stability | ENSRNOG00000009460 | 0.0915 | 0.0652 | 4.4e-06 | 0.069 | 0.054 | 0.051 | 0.062 | 5.8e-07 | 9.7e-06 | 1.6e-05 | 2.3e-06 |
| 3 | LHb | gene expression | ENSRNOG00000009460 | 0.4573 | 0.1369 | 1.4e-07 | 0.214 | 0.256 | 0.268 | 0.288 | 8.2e-06 | 8.7e-07 | 4.4e-07 | 1.4e-07 |
| 4 | Liver | gene expression | ENSRNOG00000009460 | 0.0180 | 0.0130 | 8.6e-03 | 0.014 | 0.007 | 0.006 | 0.006 | 1.0e-02 | 4.9e-02 | 6.4e-02 | 6.5e-02 |
| 5 | Liver | intron excision ratio | chr1:258458186:258476751 | 0.0356 | 0.0246 | 6.9e-04 | 0.019 | 0.018 | 0.013 | 0.018 | 3.0e-03 | 3.7e-03 | 1.3e-02 | 3.9e-03 |
| 6 | Liver | intron excision ratio | chr1:258476140:258476751 | 0.0398 | 0.0325 | 2.3e-03 | 0.020 | 0.016 | 0.004 | 0.017 | 2.6e-03 | 6.6e-03 | 1.0e-01 | 5.2e-03 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 |
|---|---|---|---|---|---|---|---|---|---|
| Reaction time mean minus median AUC | 5.6 | 7.1 | 9.4 | 1.3 | 3.1 | -2.9 | 2.9 | 2.6 | -2.8 |
| Reaction time mean AUC | 5.3 | 7.1 | 10.3 | 0.8 | 3.0 | -3.2 | 2.9 | 2.6 | -2.7 |
| Retroperitoneal fat weight | 5.0 | 16.7 | 80.2 | 9.0 | 2.8 | 1.4 | 2.7 | -1.1 | 1.1 |
| Cd content in liver | 4.9 | 5.3 | 7.8 | -2.0 | -2.8 | 2.2 | -2.6 | -2.0 | 2.2 |
| Epididymis fat weight | 4.8 | 11.3 | 54.7 | 7.4 | 2.0 | 1.2 | 1.9 | -1.4 | 1.4 |
| Soleus weight | 4.8 | 13.9 | 18.7 | 3.1 | 4.3 | -3.4 | 4.3 | 3.6 | -3.5 |
| Median of all reaction times | 4.6 | 6.2 | 9.0 | 0.4 | 2.7 | -3.0 | 2.7 | 2.6 | -2.7 |
| Reaction time mean | 4.3 | 5.9 | 8.5 | 0.8 | 2.8 | -2.9 | 2.7 | 2.3 | -2.4 |
| Incentive Sensitization - Responses | 4.3 | 4.3 | 6.9 | 2.2 | 2.6 | -2.0 | 2.6 | 1.4 | -1.4 |
| Incentive Sensitization - Breakpoint | 4.1 | 4.1 | 6.7 | 2.3 | 2.5 | -1.9 | 2.6 | 1.2 | -1.2 |
| Parametrial fat weight | 3.9 | 7.6 | 35.5 | 6.0 | 2.0 | 0.2 | 1.9 | -1.2 | 1.2 |
| Locomotion distance, session 8 | 3.9 | 5.9 | 9.0 | -2.3 | -2.9 | 2.8 | -3.0 | -1.5 | 1.5 |
| Delay discount exponential model param | 3.7 | 3.9 | 6.0 | -2.0 | -2.5 | 2.0 | -2.4 | -1.4 | 1.4 |
| Delay discount hyperbolic model param | 3.6 | 3.8 | 5.9 | -1.8 | -2.4 | 2.0 | -2.3 | -1.5 | 1.5 |
| Body weight | 3.4 | 14.4 | 65.2 | 8.1 | 3.3 | 0.2 | 3.2 | -0.0 | -0.1 |
| Liver weight, right | 3.3 | 5.5 | 16.5 | 4.1 | 2.6 | -1.5 | 2.5 | 0.7 | -0.8 |
| BMI with tail | 3.2 | 10.5 | 48.9 | 7.0 | 2.6 | 0.6 | 2.5 | -0.0 | -0.1 |
| Std. dev. reaction times | 3.2 | 4.4 | 6.8 | 1.8 | 2.6 | -2.2 | 2.5 | 1.6 | -1.8 |
| Cocaine induced anxiety | 3.2 | 3.6 | 7.4 | -2.7 | -2.3 | 1.5 | -2.3 | -0.8 | 0.7 |
| Bone: post-yield work | 3.1 | 4.2 | 6.0 | 0.4 | -1.9 | 2.4 | -2.0 | -2.4 | 2.4 |
| Area under the delay curve | 3.1 | 3.3 | 5.2 | 1.9 | 2.3 | -1.8 | 2.2 | 1.3 | -1.2 |
| Time in open arm before self-admin | 2.9 | 3.1 | 5.0 | -1.7 | -2.2 | 1.5 | -2.2 | -1.3 | 1.4 |
| Progressive ratio test 2 breakpoint | 2.8 | 3.1 | 4.8 | 1.5 | 2.2 | -1.8 | 2.1 | 1.3 | -1.6 |
| Zn content in liver | 2.7 | 3.0 | 5.8 | -0.8 | 1.3 | -1.6 | 1.3 | 2.4 | -2.4 |
| Locomotion velocity, session 8 | 2.6 | 3.1 | 4.4 | -1.6 | -2.1 | 1.7 | -2.1 | -1.5 | 1.4 |
| Delay disc. indifference point, 2s delay | 2.6 | 2.9 | 3.8 | 0.3 | 1.9 | -1.7 | 1.8 | 1.9 | -1.9 |
| Mg content in liver | 2.6 | 2.6 | 4.3 | 0.9 | 1.7 | -2.1 | 1.9 | 1.4 | -1.4 |
| BMI without tail | 2.5 | 5.2 | 23.0 | 4.8 | 2.1 | -0.2 | 1.9 | -0.0 | 0.1 |
| Social time | 2.5 | 3.2 | 4.3 | 0.6 | 2.0 | -1.8 | 2.1 | 2.1 | -1.8 |
| Delay disc. indifference point, 8s delay | 2.4 | 2.4 | 4.1 | 1.5 | 2.0 | -1.6 | 1.9 | 1.1 | -1.0 |
| Latency to leave start box in cocaine runway | 2.4 | 2.6 | 5.5 | 0.6 | 1.9 | -2.4 | 1.9 | 1.0 | -1.1 |
| Na content in liver | 2.4 | 2.6 | 3.7 | 1.7 | 1.9 | -1.7 | 1.8 | 1.1 | -1.2 |
| Progressive ratio test 2 active lever presses | 2.3 | 2.4 | 3.6 | 1.2 | 1.9 | -1.6 | 1.8 | 1.2 | -1.5 |
| Distance traveled before self-admin | 2.3 | 2.5 | 4.9 | -1.3 | 1.0 | -1.5 | 1.0 | 2.2 | -2.1 |
| Liver weight, left | 2.2 | 3.6 | 11.9 | 3.5 | 2.0 | -1.2 | 1.9 | 0.4 | -0.5 |
| Number of licking bursts | 2.2 | 2.6 | 4.3 | 0.1 | -1.6 | 1.6 | -1.7 | -2.1 | 1.9 |
| Std. dev. time between licks in bursts | 2.2 | 2.7 | 3.3 | -1.1 | -1.8 | 1.5 | -1.8 | -1.7 | 1.8 |
| Reaction time mean minus median | 2.2 | 2.9 | 4.6 | 1.5 | 2.1 | -1.7 | 2.0 | 1.3 | -1.4 |
| Mean num. licks in bursts | 2.1 | 2.5 | 4.4 | -0.0 | 1.5 | -1.5 | 1.5 | 2.1 | -2.0 |
| Condit. Reinf. active responses | 2.1 | 2.5 | 4.8 | -0.1 | -1.6 | 2.2 | -1.6 | -1.6 | 1.6 |
| Delay disc. indifference point, 16s delay | 2.1 | 2.1 | 3.3 | 1.5 | 1.8 | -1.4 | 1.7 | 1.1 | -1.0 |
| Baseline Anxiety | 2.0 | 2.1 | 6.0 | 2.4 | 1.7 | -0.9 | 1.7 | -0.0 | 0.2 |
| Condit. Reinf. inactive responses | 2.0 | 2.3 | 4.9 | 0.7 | -1.3 | 2.2 | -1.4 | -1.6 | 1.6 |
| Delay disc. indifference point, 4s delay | 2.0 | 2.1 | 3.1 | 1.2 | 1.7 | -1.6 | 1.8 | 1.2 | -1.2 |
| Total resting periods, locomotor time 2 | 2.0 | 2.1 | 4.7 | -0.1 | 1.7 | -2.2 | 1.5 | 1.3 | -1.2 |
| Progressive ratio | 2.0 | 2.3 | 3.7 | -1.8 | -1.9 | 0.9 | -1.8 | -1.1 | 1.1 |
| Novel to familiar place preference ratio | 1.9 | 2.0 | 3.0 | -0.2 | -1.4 | 1.4 | -1.3 | -1.7 | 1.7 |
| Time in closed arm before self-admin | 1.9 | 2.1 | 3.0 | 0.8 | 1.7 | -1.5 | 1.7 | 1.5 | -1.4 |
| Time >=10cm from walls, locomotor time 2 | 1.9 | 2.0 | 4.2 | -0.3 | -1.6 | 2.1 | -1.6 | -1.2 | 1.1 |
| Reaction time omissions | 1.8 | 2.4 | 4.1 | 1.6 | 2.0 | -1.6 | 1.9 | 0.9 | -0.9 |
| Bone: cortical area | 1.8 | 2.7 | 7.2 | 2.7 | -0.6 | 1.9 | -0.6 | -1.6 | 1.5 |
| Time in open arm after self-admin | 1.8 | 2.0 | 3.5 | -0.2 | -1.3 | 1.1 | -1.3 | -1.9 | 1.8 |
| Latency to leave start box in cocaine runway, M | 1.8 | 1.7 | 2.9 | -0.1 | 1.3 | -1.7 | 1.3 | 1.3 | -1.3 |
| Cocaine response after cond. corrected | 1.7 | 1.9 | 7.6 | -2.8 | -0.6 | -0.2 | -0.6 | 1.3 | -1.1 |
| Intermitt. access day 1 inactive lever presses | 1.7 | 1.9 | 4.9 | 2.2 | 1.5 | -1.0 | 1.5 | -0.5 | 0.8 |
| Bone: cortical tissue density | 1.7 | 2.2 | 8.7 | -3.0 | -0.5 | -0.5 | -0.5 | 1.4 | -1.3 |
| Time in closed arm after self-admin | 1.7 | 1.7 | 2.9 | -0.6 | 1.2 | -1.3 | 1.2 | 1.7 | -1.6 |
| Time to tail flick, vehicle, before self-admin | 1.7 | 1.8 | 2.4 | 0.4 | -1.3 | 1.5 | -1.3 | -1.6 | 1.6 |
| Time in familiar zone, hab. session 1 | 1.6 | 1.6 | 2.0 | 1.0 | 1.4 | -1.0 | 1.4 | 1.3 | -1.3 |
| Time in novel zone, NPP test | 1.6 | 1.7 | 3.1 | 0.2 | -1.1 | 1.2 | -1.1 | -1.7 | 1.7 |
| Bone: cortical thickness | 1.6 | 2.7 | 7.0 | 1.3 | -1.4 | 2.6 | -1.4 | -1.4 | 1.3 |
| Bone: periosteal perimeter | 1.6 | 2.7 | 11.6 | 3.4 | 1.5 | -0.4 | 1.4 | 0.2 | -0.3 |
| Bone: trabecular tissue density | 1.6 | 2.3 | 3.9 | -1.3 | 0.9 | -1.7 | 1.1 | 2.0 | -1.8 |
| Latency to leave start box in cocaine runway, F | 1.6 | 1.7 | 3.2 | 0.9 | 1.7 | -1.8 | 1.7 | 0.7 | -0.7 |
| Delay discounting total patch changes 6 sec | 1.5 | 2.2 | 6.3 | 2.5 | -0.4 | 1.4 | -0.1 | -1.5 | 1.7 |
| Reaction time trials on left | 1.5 | 2.2 | 3.4 | 1.1 | 1.9 | -1.7 | 1.7 | 1.0 | -1.3 |
| Reaction time trials completed | 1.5 | 2.2 | 3.4 | 1.1 | 1.9 | -1.7 | 1.7 | 1.0 | -1.3 |
| Cocaine response after cond. not corrected | 1.5 | 1.7 | 7.7 | -2.8 | -0.8 | -0.2 | -0.7 | 0.8 | -0.8 |
| Short access total locomotion | 1.5 | 1.5 | 3.2 | -1.0 | 0.6 | -1.0 | 0.6 | 1.8 | -1.8 |
| Bone: cortical apparent density | 1.5 | 2.0 | 8.2 | -2.9 | -0.5 | -0.4 | -0.5 | 1.3 | -1.2 |
| Reaction time trials AUC | 1.4 | 2.0 | 3.1 | 1.1 | 1.8 | -1.6 | 1.6 | 0.9 | -1.2 |
| Post-drug Anxiety | 1.4 | 1.6 | 2.2 | -1.3 | -1.5 | 1.5 | -1.5 | -0.8 | 0.7 |
| Condit. Reinf. active minus inactive responses | 1.4 | 1.6 | 2.1 | -1.1 | -1.5 | 1.4 | -1.5 | -1.1 | 1.1 |
| Total locomotion distance, hab. session 1 | 1.4 | 2.0 | 2.8 | -0.2 | -1.4 | 1.6 | -1.5 | -1.6 | 1.7 |
| Novelty place preference | 1.4 | 1.4 | 2.2 | -0.3 | -1.2 | 1.1 | -1.1 | -1.5 | 1.5 |
| Bone: apparent density | 1.4 | 2.2 | 4.1 | 2.0 | -0.5 | 1.5 | -0.6 | -1.8 | 1.9 |
| Bone: trabecular number | 1.4 | 2.1 | 3.6 | 1.7 | -0.6 | 1.4 | -0.7 | -1.8 | 1.9 |
| Bone: trabecular thickness | 1.4 | 1.7 | 8.5 | 2.9 | 0.6 | 0.6 | 0.7 | -0.7 | 0.6 |
| Total heroin consumption | 1.4 | 1.7 | 6.0 | 2.5 | 1.2 | -0.8 | 1.3 | -0.4 | 0.3 |
| Bouts of movement, locomotor time 2 | 1.4 | 1.5 | 3.7 | -0.3 | 1.3 | -1.9 | 1.2 | 1.1 | -1.0 |
| Rb content in liver | 1.4 | 1.7 | 3.2 | 0.6 | 1.5 | -1.8 | 1.6 | 1.0 | -0.9 |
| Glucose | 1.3 | 2.0 | 8.5 | 2.9 | 1.2 | -0.5 | 1.4 | 0.0 | -0.0 |
| Reaction time number correct | 1.3 | 1.9 | 3.0 | 1.0 | 1.7 | -1.6 | 1.6 | 0.9 | -1.2 |
| Reaction time trials correct on left | 1.3 | 1.9 | 3.0 | 1.0 | 1.7 | -1.6 | 1.6 | 0.9 | -1.2 |
| Conditioned reinforcement - actives | 1.3 | 1.3 | 5.2 | -2.3 | -1.1 | -0.3 | -1.0 | 0.3 | -0.4 |
| Conditioned locomotion | 1.3 | 1.6 | 5.7 | -2.4 | -1.4 | 0.3 | -1.3 | 0.2 | -0.1 |
| Intermittent access intake day 1-15 change | 1.3 | 1.3 | 2.5 | 1.0 | 1.5 | -1.3 | 1.6 | 0.5 | -0.5 |
| Incentive salience index mean | 1.3 | 1.6 | 2.3 | -1.2 | -1.5 | 1.5 | -1.5 | -0.8 | 0.8 |
| Locomotion velocity, hab. session 1 | 1.3 | 1.8 | 2.3 | -0.3 | -1.4 | 1.5 | -1.5 | -1.5 | 1.5 |
| Bone: stiffness | 1.3 | 2.0 | 3.9 | 0.7 | -1.4 | 2.0 | -1.3 | -1.4 | 1.4 |
| Breakpoint value in progressive ratio session | 1.3 | 1.4 | 3.7 | 1.9 | 1.3 | -1.0 | 1.3 | -0.5 | 0.5 |
| Extinction: sum of active levers before priming | 1.3 | 1.3 | 2.2 | 1.2 | 1.5 | -1.3 | 1.5 | 0.2 | -0.4 |
| Ambulatory time before self-admin | 1.3 | 1.3 | 2.6 | -1.1 | 0.6 | -1.0 | 0.6 | 1.6 | -1.6 |
| Seeking ratio, delayed vs. immediate footshock | 1.3 | 1.5 | 4.8 | -2.2 | -1.5 | 0.5 | -1.3 | -0.3 | 0.2 |
| Seeking ratio, punishment vs. effort | 1.3 | 1.6 | 2.3 | 0.7 | 1.5 | -0.9 | 1.5 | 1.4 | -1.4 |
| Co content in liver | 1.3 | 1.6 | 2.4 | -1.3 | -1.5 | 1.5 | -1.6 | -0.5 | 0.7 |
| Tibialis anterior weight | 1.2 | 4.0 | 6.4 | 2.3 | 2.4 | -1.9 | 2.5 | 1.2 | -1.2 |
| Locomotion velocity, session 2 | 1.2 | 1.4 | 4.8 | -2.2 | -1.2 | 0.7 | -1.2 | 0.2 | -0.2 |
| Time in novel zone, hab. session 1 | 1.2 | 1.2 | 2.2 | -0.5 | -1.0 | 0.7 | -1.0 | -1.5 | 1.4 |
| Pavlov. Cond. intertrial magazine entries | 1.2 | 1.5 | 3.6 | 0.0 | -1.3 | 1.9 | -1.3 | -0.9 | 1.1 |
| Bone surface | 1.2 | 2.1 | 2.9 | 1.5 | -0.8 | 1.7 | -0.9 | -1.7 | 1.7 |
| Bone: maximum diameter | 1.2 | 2.1 | 10.0 | 3.2 | 0.8 | 0.2 | 0.8 | -1.0 | 0.9 |
| Delta time to tail flick, test, before/after SA | 1.2 | 1.0 | 2.1 | 1.1 | -0.2 | 0.9 | -0.2 | -1.4 | 1.4 |
| Fe content in liver | 1.2 | 1.5 | 2.3 | 0.2 | -1.2 | 1.5 | -0.9 | -1.5 | 1.5 |
| Delay discounting total patch changes 12 sec | 1.1 | 1.5 | 5.1 | 2.3 | -0.2 | 0.9 | 0.1 | -1.1 | 1.3 |
| Intermittent access intake escalation | 1.1 | 1.0 | 1.6 | 0.1 | 1.2 | -1.0 | 1.3 | 1.1 | -1.1 |
| Total locomotion distance, NPP test | 1.1 | 1.5 | 2.5 | -0.4 | -1.3 | 1.6 | -1.4 | -1.0 | 1.1 |
| Locomotion velocity, NPP test | 1.1 | 1.6 | 2.5 | -1.0 | -1.5 | 1.6 | -1.6 | -0.8 | 0.9 |
| Bone: connectivity density | 1.1 | 1.7 | 2.9 | 0.9 | -0.9 | 1.5 | -1.0 | -1.7 | 1.7 |
| Bone: maximum force | 1.1 | 1.9 | 4.2 | 1.4 | -1.1 | 2.1 | -1.0 | -1.2 | 1.1 |
| Delta time to tail flick, vehicle, before/after SA | 1.1 | 1.1 | 1.7 | 1.0 | 1.3 | -1.0 | 1.3 | 0.8 | -0.8 |
| Delay discounting total patch changes 18 sec | 1.0 | 1.3 | 5.6 | 2.4 | 0.4 | 0.1 | 0.8 | -0.7 | 0.8 |
| Locomotor testing rearing | 1.0 | 1.6 | 2.4 | -0.1 | 1.3 | -1.3 | 1.3 | 1.5 | -1.4 |
| Condit. Reinf. active responses | 1.0 | 1.4 | 5.6 | 2.4 | 0.5 | 0.2 | 0.5 | -1.1 | 1.1 |
| Intermittent access day 1 locomotion | 1.0 | 1.0 | 1.8 | -0.9 | 0.6 | -0.9 | 0.6 | 1.3 | -1.3 |
| Bone: elastic displacement | 1.0 | 1.1 | 1.6 | 0.2 | 1.1 | -1.0 | 1.1 | 1.2 | -1.3 |
| Bone: endosteal perimeter | 1.0 | 2.0 | 5.8 | 2.4 | 1.5 | -0.9 | 1.5 | 0.5 | -0.5 |
| Bone: maximum moment | 1.0 | 1.8 | 3.9 | 1.4 | -1.0 | 2.0 | -1.0 | -1.2 | 1.2 |
| Delay disc. indifference point, 24s delay | 1.0 | 1.0 | 2.6 | 1.6 | 1.2 | -0.8 | 1.1 | 0.2 | -0.1 |
| Intraocular pressure | 0.9 | 1.2 | 2.8 | 1.5 | -0.1 | 0.7 | 0.1 | -1.4 | 1.7 |
| Delay discounting total patch changes 0 sec | 0.9 | 1.5 | 5.5 | 2.4 | -0.2 | 1.3 | 0.3 | -0.8 | 1.0 |
| Delay discounting total patch changes 24 sec | 0.9 | 1.1 | 3.7 | 1.9 | 0.0 | 0.4 | 0.4 | -1.1 | 1.3 |
| Reaction time false alarm rate | 0.9 | 1.3 | 2.6 | -0.6 | -1.4 | 1.6 | -1.4 | -0.6 | 0.8 |
| Intermittent access day 15 total infusions | 0.9 | 1.0 | 1.5 | -0.0 | 1.2 | -1.2 | 1.1 | 1.0 | -1.1 |
| Progressive ratio test 1 active lever presses | 0.9 | 0.9 | 1.7 | -0.1 | 1.1 | -1.3 | 0.8 | 0.7 | -1.1 |
| Bone volume | 0.9 | 1.5 | 5.9 | 2.4 | 0.1 | 1.0 | 0.0 | -1.0 | 1.1 |
| Bone: elastic work | 0.9 | 1.2 | 2.6 | 0.4 | 0.8 | -0.5 | 1.0 | 1.6 | -1.6 |
| Distance traveled after self-admin | 0.9 | 1.0 | 2.0 | -1.2 | 0.5 | -1.1 | 0.5 | 1.4 | -1.2 |
| Active lever presses in extinction session 6 | 0.9 | 0.9 | 1.7 | 1.3 | 1.2 | -0.8 | 1.2 | 0.2 | -0.4 |
| Change in fecal boli incidents, locomotor task | 0.9 | 0.9 | 1.5 | 0.2 | -0.9 | 1.2 | -0.9 | -0.9 | 1.1 |
| Vertical activity count, locomotor time 2 | 0.9 | 0.9 | 1.7 | -0.3 | -1.1 | 1.3 | -1.1 | -0.9 | 0.7 |
| Se content in liver | 0.9 | 1.1 | 1.6 | -0.2 | -1.2 | 1.1 | -0.8 | -1.3 | 1.2 |
| Sr content in liver | 0.9 | 0.8 | 3.3 | -1.8 | -0.3 | -0.4 | 0.1 | 0.9 | -0.7 |
| Extensor digitorum longus weight | 0.8 | 3.1 | 11.2 | 3.3 | 1.8 | -0.4 | 2.0 | 0.2 | -0.2 |
| Delay discounting water rate 12 sec | 0.8 | 1.2 | 2.7 | 1.6 | -0.3 | 1.2 | -0.3 | -1.3 | 1.1 |
| Condit. Reinf. lever reinforcers received | 0.8 | 1.1 | 3.3 | 1.8 | 0.1 | 0.5 | 0.0 | -1.2 | 1.3 |
| Intermittent access day 15 total locomotion | 0.8 | 0.8 | 1.6 | 1.3 | 1.2 | -0.7 | 1.2 | 0.2 | -0.1 |
| Bone: final force | 0.8 | 1.4 | 3.6 | 1.9 | -0.5 | 1.6 | -0.5 | -0.9 | 0.8 |
| Bone: final moment | 0.8 | 1.3 | 3.9 | 2.0 | -0.4 | 1.5 | -0.4 | -0.8 | 0.8 |
| Bone: periosteal estimation | 0.8 | 1.7 | 6.2 | 2.5 | -0.2 | 1.3 | -0.2 | -1.1 | 1.0 |
| Delta time in open arm before/after self-admin | 0.8 | 0.7 | 2.0 | 0.9 | -0.0 | -0.0 | -0.0 | -1.4 | 1.3 |
| Ambulatory time after self-admin | 0.8 | 0.9 | 1.4 | -0.9 | 0.6 | -1.2 | 0.6 | 1.2 | -0.9 |
| Rest time, locomotor task time 1 | 0.8 | 0.9 | 1.4 | -1.1 | -1.1 | 1.2 | -1.2 | -0.2 | 0.4 |
| Weight adjusted by age | 0.8 | 0.9 | 2.6 | 1.6 | 1.1 | 0.3 | 1.1 | 0.5 | -0.5 |
| Heart weight | 0.7 | 0.9 | 4.4 | 2.1 | 0.6 | 0.7 | 0.6 | 0.1 | -0.1 |
| Food consumed during 24 hour testing period | 0.7 | 0.8 | 1.5 | -0.7 | -1.2 | 0.9 | -1.1 | -0.7 | 0.7 |
| Indifference point 0 sec | 0.7 | 1.2 | 4.5 | 2.1 | -0.2 | 1.2 | 0.3 | -0.7 | 0.9 |
| Delay discounting water rate 24 sec | 0.7 | 0.9 | 1.3 | 1.1 | 1.0 | -0.1 | 1.0 | 1.1 | -1.0 |
| Condit. Reinf. active minus inactive responses | 0.7 | 0.8 | 3.1 | 1.8 | 0.4 | 0.1 | 0.3 | -0.9 | 0.9 |
| Pavlov. Cond. lever latency | 0.7 | 1.0 | 1.8 | -1.3 | 0.3 | -0.6 | 0.3 | 1.3 | -1.4 |
| Intermittent access total locomotion | 0.7 | 0.8 | 1.6 | -0.6 | 0.6 | -0.7 | 0.7 | 1.3 | -1.2 |
| Short access day 1 locomotion | 0.7 | 0.8 | 1.7 | 0.5 | 1.1 | -1.3 | 0.9 | 0.7 | -0.5 |
| Stereotopy head waving duration, day 7 | 0.7 | 0.8 | 1.2 | 1.1 | 1.1 | -1.1 | 1.1 | 0.3 | -0.2 |
| Condit. Reinf. active-inactive response ratio | 0.7 | 0.8 | 1.0 | -1.0 | -1.0 | 0.7 | -1.0 | -0.9 | 0.8 |
| Bone: minimum diameter | 0.7 | 1.3 | 5.6 | 2.4 | 0.1 | 1.0 | 0.1 | -0.8 | 0.7 |
| Bouts of movement, locomotor time 1 | 0.7 | 0.8 | 1.2 | 1.1 | 1.1 | -1.1 | 1.0 | -0.0 | -0.2 |
| Run reversals in cocaine runway, males | 0.7 | 0.7 | 1.6 | -0.8 | 0.4 | -0.4 | 0.4 | 1.1 | -1.3 |
| Reaction time premature initiations | 0.6 | 0.9 | 1.6 | 0.6 | 1.1 | -0.5 | 0.9 | 1.0 | -1.3 |
| Intermittent access intake escalation 2 | 0.6 | 0.6 | 1.1 | 0.2 | 1.0 | -0.9 | 1.0 | 0.6 | -0.8 |
| Intermitt. access escalation Index | 0.6 | 0.6 | 0.9 | 0.3 | 0.9 | -1.0 | 0.9 | 0.7 | -0.6 |
| One hour access (0.3 mA shock) | 0.6 | 0.7 | 1.8 | 0.7 | 1.0 | -1.3 | 1.0 | -0.2 | 0.1 |
| Context. condit. distance diff. score | 0.6 | 0.7 | 1.2 | -0.7 | -1.1 | 1.1 | -1.1 | -0.5 | 0.4 |
| Locomotion distance, session 3 | 0.6 | 0.7 | 2.2 | -1.5 | -0.7 | 0.5 | -0.7 | 0.6 | -0.7 |
| Locomotion velocity, session 7 | 0.6 | 0.7 | 1.7 | -0.3 | -1.0 | 1.3 | -1.0 | -0.5 | 0.5 |
| Bone: cortical porosity | 0.6 | 0.7 | 2.9 | 1.7 | 0.5 | -0.0 | 0.5 | -0.6 | 0.6 |
| Sum of active levers in priming session hrs 5-6 | 0.6 | 0.6 | 1.5 | 0.6 | 0.9 | -1.2 | 0.9 | -0.2 | 0.0 |
| Time >=10cm from walls, locomotor time 1 | 0.6 | 0.6 | 0.9 | -0.5 | -0.9 | 0.8 | -0.9 | -0.7 | 0.8 |
| Distance moved, locomotor task time 1 | 0.6 | 0.7 | 1.0 | 0.6 | 0.9 | -0.8 | 1.0 | 0.7 | -0.8 |
| Distance moved, locomotor task time 2 | 0.6 | 0.7 | 1.5 | -0.2 | -1.0 | 1.2 | -1.0 | -0.7 | 0.5 |
| Locomotion in novel chamber post-restriction | 0.6 | 0.7 | 1.3 | -1.2 | -0.6 | 0.1 | -0.5 | 1.0 | -1.0 |
| K content in liver | 0.6 | 0.6 | 1.5 | 0.3 | 0.8 | -1.2 | 0.9 | 0.7 | -0.7 |
| Right kidney weight | 0.5 | 1.3 | 2.8 | 1.7 | 0.5 | 1.5 | 0.4 | 1.1 | -1.2 |
| Length without tail | 0.5 | 1.1 | 4.3 | 2.1 | -0.0 | 1.3 | 0.0 | -0.6 | 0.4 |
| Mean time between licks in bursts | 0.5 | 0.7 | 2.0 | 0.2 | -0.5 | 0.2 | -0.5 | -1.3 | 1.4 |
| Delay discounting time to switch 0 sec | 0.5 | 0.7 | 1.5 | -1.0 | 0.5 | -1.2 | 0.5 | 0.8 | -0.8 |
| Delay discounting water rate 0 sec | 0.5 | 0.8 | 2.4 | 1.5 | -0.2 | 1.3 | -0.1 | -0.5 | 0.5 |
| Light reinforcement 2 | 0.5 | 0.7 | 1.9 | -1.4 | -0.9 | 0.5 | -1.1 | -0.1 | 0.1 |
| Social response proportion | 0.5 | 0.5 | 1.2 | 0.4 | 0.8 | -0.2 | 0.8 | 1.1 | -0.9 |
| Condit. Reinf. active-inactive response ratio | 0.5 | 0.5 | 2.2 | 1.5 | 0.4 | 0.0 | 0.4 | -0.4 | 0.5 |
| Pavlov. Cond. magazine entry latency | 0.5 | 0.5 | 0.9 | 0.9 | 0.8 | -1.0 | 0.9 | 0.2 | -0.2 |
| Intermittent access terminal intake (last 3 days) | 0.5 | 0.6 | 0.9 | 0.3 | 1.0 | -0.9 | 0.8 | 0.5 | -0.8 |
| Progressive ratio test 1 breakpoint | 0.5 | 0.5 | 1.1 | -0.2 | 0.8 | -1.0 | 0.5 | 0.5 | -0.9 |
| Short access day 1 total inactive lever presses | 0.5 | 0.6 | 1.2 | -0.0 | -0.6 | 0.7 | -0.8 | -1.1 | 0.8 |
| Short access day 10 total infusions | 0.5 | 0.5 | 1.4 | -1.2 | 0.2 | -0.6 | 0.0 | 0.7 | -0.9 |
| Locomotion distance, session 1 | 0.5 | 0.7 | 2.6 | -1.6 | -0.7 | 0.4 | -0.8 | 0.3 | -0.2 |
| Total zone transitions, hab. session 2 | 0.5 | 0.6 | 0.9 | 0.3 | 0.8 | -0.8 | 0.8 | 0.9 | -0.8 |
| Delta time in closed arm before/after self-admin | 0.5 | 0.5 | 1.6 | -1.3 | -0.7 | 0.6 | -0.7 | 0.1 | -0.2 |
| Diff in mean of infusions in LGA sessions | 0.5 | 0.5 | 1.5 | 1.2 | 0.4 | -0.5 | 0.5 | -0.8 | 0.7 |
| Time to tail flick, test, before self-admin | 0.5 | 0.5 | 1.1 | -1.0 | -0.2 | -0.5 | -0.2 | 0.9 | -0.9 |
| Rest time, locomotor task time 2 | 0.5 | 0.6 | 0.9 | -0.3 | 0.9 | -1.0 | 0.8 | 1.0 | -0.7 |
| Mn content in liver | 0.5 | 0.6 | 0.9 | 0.5 | 0.8 | -0.7 | 1.0 | 0.8 | -0.7 |
| Left kidney weight | 0.4 | 1.1 | 3.6 | 1.1 | -0.2 | 1.9 | -0.2 | 0.9 | -0.9 |
| Length with tail | 0.4 | 1.4 | 6.6 | 2.6 | 1.0 | 0.0 | 1.0 | -0.2 | 0.1 |
| Social responses | 0.4 | 0.5 | 2.5 | 1.6 | 0.5 | 0.5 | 0.5 | -0.3 | 0.3 |
| Cocaine response before conditioning | 0.4 | 0.5 | 1.5 | 0.5 | -0.4 | 0.3 | -0.3 | -1.2 | 1.0 |
| Condit. Reinf. inactive responses | 0.4 | 0.5 | 2.1 | 1.4 | 0.5 | 0.0 | 0.4 | -0.5 | 0.5 |
| Condit. Reinf. lever presses | 0.4 | 0.6 | 2.4 | 1.6 | -0.0 | 0.4 | 0.1 | -0.7 | 0.8 |
| Pavlov. Cond. response bias | 0.4 | 0.5 | 1.5 | 1.2 | 0.1 | 0.0 | 0.0 | -0.9 | 0.9 |
| Intermitt. access day 15 inactive lever presses | 0.4 | 0.5 | 1.4 | 1.2 | 0.8 | -0.3 | 0.9 | 0.3 | 0.1 |
| Short access day 10 total inactive lever presses | 0.4 | 0.4 | 1.8 | 1.3 | 0.4 | 0.3 | 0.4 | -0.4 | 0.5 |
| Short access day 10 total locomotion | 0.4 | 0.5 | 1.0 | -0.3 | 0.5 | -0.5 | 0.6 | 1.0 | -0.9 |
| Locomotion velocity, session 3 | 0.4 | 0.5 | 1.8 | -1.4 | -0.7 | 0.4 | -0.7 | 0.2 | -0.3 |
| Locomotion distance, session 7 | 0.4 | 0.5 | 1.2 | -0.5 | -0.8 | 1.1 | -0.8 | -0.0 | -0.0 |
| Degree of sensitization distance | 0.4 | 0.4 | 1.0 | 1.0 | -0.1 | 0.4 | -0.0 | -0.7 | 0.7 |
| Time in familiar zone, hab. session 2 | 0.4 | 0.4 | 0.8 | 0.9 | 0.2 | -0.1 | 0.2 | -0.8 | 0.8 |
| Pavlov. Cond. change in total contacts | 0.4 | 0.5 | 0.7 | 0.8 | 0.7 | -0.3 | 0.7 | 0.7 | -0.7 |
| Pavlov. Cond. magazine entry number | 0.4 | 0.5 | 0.6 | -0.7 | -0.8 | 0.6 | -0.7 | -0.6 | 0.7 |
| Total resting periods, locomotor time 1 | 0.4 | 0.5 | 0.8 | 0.8 | 0.9 | -0.9 | 0.8 | 0.1 | -0.2 |
| Vertical activity count, locomotor time 1 | 0.4 | 0.4 | 0.9 | 0.2 | 0.6 | -0.5 | 0.6 | 0.8 | -0.9 |
| Indifference point AUC | 0.3 | 0.4 | 1.8 | 1.4 | 0.2 | -0.1 | 0.4 | -0.4 | 0.5 |
| Locomotor testing distance | 0.3 | 0.6 | 1.1 | -0.9 | 0.4 | -0.5 | 0.4 | 1.0 | -1.0 |
| Conditioned locomotion | 0.3 | 0.4 | 0.6 | 0.0 | 0.6 | -0.8 | 0.8 | 0.6 | -0.5 |
| Saline control response | 0.3 | 0.4 | 0.8 | -0.2 | 0.6 | -0.6 | 0.7 | 0.9 | -0.7 |
| Pavlov. Cond. index score | 0.3 | 0.4 | 1.7 | 1.3 | 0.4 | -0.3 | 0.4 | -0.5 | 0.5 |
| Pavlov. Cond. latency score | 0.3 | 0.4 | 1.3 | 1.1 | 0.3 | -0.2 | 0.3 | -0.6 | 0.6 |
| Pavlov. Cond. lever contacts | 0.3 | 0.5 | 1.3 | 1.2 | -0.1 | 0.2 | -0.1 | -0.8 | 0.8 |
| Pavlov. Cond. magazine entry number | 0.3 | 0.3 | 0.7 | -0.8 | -0.6 | 0.7 | -0.6 | -0.1 | 0.1 |
| Pavlov. Cond. intertrial magazine entries | 0.3 | 0.4 | 1.1 | 1.1 | -0.1 | 0.7 | -0.1 | -0.5 | 0.5 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.3 | 0.3 | 1.3 | 1.2 | 0.4 | -0.4 | 0.4 | -0.3 | 0.3 |
| Intermittent access total infusions | 0.3 | 0.3 | 0.6 | -0.3 | 0.6 | -0.7 | 0.4 | 0.5 | -0.8 |
| Intermittent access standard deviation | 0.3 | 0.4 | 0.7 | 0.5 | 0.7 | -0.9 | 0.7 | -0.3 | 0.0 |
| Short access total infusions | 0.3 | 0.3 | 0.9 | -1.0 | 0.0 | -0.2 | -0.2 | 0.5 | -0.7 |
| Locomotion distance, session 2 | 0.3 | 0.5 | 0.9 | -0.8 | -0.7 | 1.0 | -0.9 | 0.1 | -0.1 |
| Stereotopy head waving bouts, day 3 | 0.3 | 0.3 | 0.6 | -0.4 | 0.5 | -0.8 | 0.4 | 0.6 | -0.6 |
| Degree of sensitization stereotypy | 0.3 | 0.3 | 1.3 | 1.1 | 0.3 | 0.1 | 0.3 | -0.4 | 0.4 |
| Condit. Reinf. lever presses | 0.3 | 0.3 | 0.7 | -0.6 | -0.7 | 0.9 | -0.7 | -0.2 | 0.1 |
| Time in novel zone, hab. session 2 | 0.3 | 0.3 | 0.6 | -0.8 | -0.2 | 0.1 | -0.1 | 0.7 | -0.7 |
| Bone: cortical porosity | 0.3 | 0.3 | 1.4 | 1.2 | 0.2 | 0.1 | 0.2 | -0.6 | 0.5 |
| Bone: cortical thickness | 0.3 | 0.3 | 1.2 | 1.1 | -0.0 | 0.9 | -0.1 | 0.0 | -0.1 |
| Bone: marrow area | 0.3 | 0.6 | 2.8 | 1.7 | 0.5 | 0.1 | 0.4 | -0.4 | 0.4 |
| Time to tail flick, test, after self-admin | 0.3 | 0.4 | 1.0 | 1.0 | 0.3 | -0.1 | 0.3 | -0.7 | 0.6 |
| Food seeking constrained by brief footshock | 0.3 | 0.4 | 1.5 | -1.2 | -0.7 | 0.0 | -0.6 | -0.2 | 0.2 |
| Tail length | 0.2 | 0.7 | 2.0 | 1.4 | 0.8 | -0.8 | 0.8 | -0.2 | 0.2 |
| Water consumed over 24 hours | 0.2 | 0.2 | 0.7 | -0.8 | -0.3 | -0.0 | -0.3 | 0.4 | -0.5 |
| Indifference point function ln k | 0.2 | 0.2 | 0.6 | -0.8 | -0.4 | 0.7 | -0.3 | 0.2 | -0.1 |
| Indifference point function log k | 0.2 | 0.2 | 0.6 | -0.8 | -0.4 | 0.7 | -0.3 | 0.2 | -0.1 |
| Delay discounting water rate 6 sec | 0.2 | 0.2 | 0.7 | 0.8 | 0.4 | 0.2 | 0.4 | 0.4 | -0.5 |
| Light reinforcement 1 | 0.2 | 0.3 | 0.8 | -0.9 | -0.5 | 0.5 | -0.6 | 0.3 | -0.2 |
| Reaction time num false alarms | 0.2 | 0.3 | 0.9 | -0.3 | -0.6 | 0.9 | -0.7 | -0.1 | 0.2 |
| Pavlov. Cond. change in total contacts | 0.2 | 0.3 | 1.1 | 1.0 | 0.2 | -0.2 | 0.2 | -0.6 | 0.6 |
| Progressive ratio test 2 inactive lever presses | 0.2 | 0.2 | 0.5 | 0.5 | -0.1 | 0.1 | -0.2 | -0.7 | 0.6 |
| Total sessions with >9 infusions | 0.2 | 0.2 | 0.5 | -0.7 | 0.2 | -0.1 | -0.0 | 0.7 | -0.7 |
| Short access day 1 total infusions | 0.2 | 0.2 | 0.5 | -0.0 | 0.6 | -0.3 | 0.3 | 0.5 | -0.7 |
| Compulsive drug intake | 0.2 | 0.2 | 0.8 | 0.4 | -0.0 | 0.4 | -0.1 | -0.5 | 0.9 |
| One hour access (shock baseline) | 0.2 | 0.2 | 0.7 | -0.3 | 0.4 | -0.8 | 0.4 | 0.2 | -0.5 |
| Total zone transitions, hab. session 1 | 0.2 | 0.2 | 0.4 | 0.5 | 0.5 | -0.1 | 0.5 | 0.6 | -0.5 |
| Pavlov. Cond. index score | 0.2 | 0.2 | 0.3 | 0.6 | 0.4 | -0.1 | 0.4 | 0.5 | -0.6 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.2 | 0.2 | 0.4 | 0.7 | 0.4 | -0.1 | 0.4 | 0.4 | -0.5 |
| Pavlov. Cond. response bias | 0.2 | 0.2 | 0.5 | 0.3 | 0.4 | -0.2 | 0.4 | 0.6 | -0.7 |
| Bone: endosteal estimation | 0.2 | 0.5 | 2.6 | 1.6 | 0.5 | 0.0 | 0.4 | -0.4 | 0.3 |
| Bone: trabecular spacing | 0.2 | 0.3 | 1.5 | -1.2 | -0.1 | -0.6 | -0.1 | 0.2 | -0.2 |
| Delay disc. indifference point, 0s delay | 0.2 | 0.2 | 0.6 | 0.2 | 0.4 | -0.0 | 0.4 | 0.7 | -0.7 |
| Fecal boli incidents, locomotor time 1 | 0.2 | 0.2 | 0.4 | 0.2 | -0.3 | 0.5 | -0.4 | -0.6 | 0.6 |
| Locomotion in novel chamber | 0.2 | 0.2 | 0.5 | -0.6 | -0.3 | 0.0 | -0.2 | 0.7 | -0.6 |
| Tibia length | 0.1 | 0.3 | 0.9 | 0.3 | -0.6 | 0.9 | -0.4 | -0.4 | 0.4 |
| Delay discounting water rate 18 sec | 0.1 | 0.1 | 0.1 | 0.3 | 0.1 | 0.4 | 0.1 | 0.4 | -0.3 |
| Locomotor activity | 0.1 | 0.1 | 0.2 | -0.1 | 0.4 | -0.3 | 0.4 | 0.3 | -0.3 |
| Reaction time num false alarms AUC | 0.1 | 0.1 | 0.4 | -0.2 | -0.2 | 0.6 | -0.3 | 0.3 | -0.2 |
| Reaction time premature initiation rate | 0.1 | 0.1 | 0.3 | -0.0 | 0.1 | 0.4 | 0.0 | 0.5 | -0.6 |
| Conditioned reinforcement - inactives | 0.1 | 0.2 | 0.4 | 0.4 | 0.1 | -0.4 | -0.1 | -0.6 | 0.5 |
| Lifetime Intake | 0.1 | 0.2 | 0.4 | -0.6 | 0.2 | -0.3 | -0.0 | 0.3 | -0.6 |
| Progressive ratio test 1 inactive lever presses | 0.1 | 0.1 | 0.2 | 0.2 | 0.2 | -0.3 | 0.1 | -0.4 | 0.4 |
| Locomotion velocity, session 1 | 0.1 | 0.1 | 0.4 | -0.7 | -0.2 | 0.0 | -0.2 | -0.1 | 0.2 |
| Stereotopy head waving bouts, day 7 | 0.1 | 0.1 | 0.3 | 0.4 | -0.1 | 0.1 | -0.1 | -0.5 | 0.5 |
| Total locomotion distance, hab. session 2 | 0.1 | 0.1 | 0.2 | 0.4 | -0.2 | 0.5 | -0.2 | -0.3 | 0.3 |
| Pavlov. Cond. lever latency | 0.1 | 0.1 | 0.3 | 0.1 | 0.2 | -0.5 | 0.2 | -0.4 | 0.5 |
| Pavlov. Cond. latency score | 0.1 | 0.1 | 0.3 | 0.4 | 0.3 | -0.0 | 0.3 | 0.4 | -0.5 |
| Pavlov. Cond. lever contacts | 0.1 | 0.2 | 0.3 | 0.5 | 0.3 | -0.0 | 0.3 | 0.4 | -0.5 |
| Delta ambulatory time before/after self-admin | 0.1 | 0.2 | 0.4 | 0.3 | -0.2 | 0.2 | -0.2 | -0.5 | 0.6 |
| Time to tail flick, vehicle, after self-admin | 0.1 | 0.1 | 0.4 | 0.2 | -0.2 | 0.7 | -0.3 | -0.3 | 0.3 |
| Run reversals in cocaine runway, females | 0.1 | 0.1 | 0.3 | 0.6 | 0.2 | -0.0 | 0.2 | -0.4 | 0.5 |
| Cu content in liver | 0.1 | 0.1 | 0.2 | -0.2 | -0.1 | -0.3 | 0.1 | 0.5 | -0.4 |
| Times rat made contact with spout | 0.0 | 0.0 | 0.1 | 0.2 | -0.2 | 0.2 | -0.3 | -0.3 | 0.1 |
| Intermittent access day 1 total infusions | 0.0 | 0.1 | 0.2 | -0.4 | 0.0 | -0.2 | -0.1 | 0.1 | -0.4 |
| Number of responses in last shaping day | 0.0 | 0.0 | 0.0 | -0.0 | 0.1 | -0.1 | -0.2 | -0.1 | 0.1 |
| Stereotopy head waving duration, day 3 | 0.0 | 0.1 | 0.2 | -0.3 | 0.1 | -0.4 | 0.0 | -0.1 | 0.1 |
| Locomotion velocity, hab. session 2 | 0.0 | 0.1 | 0.3 | 0.5 | 0.1 | 0.2 | 0.1 | -0.0 | 0.1 |
| Total zone transitions, NPP test | 0.0 | 0.1 | 0.1 | 0.2 | 0.3 | -0.0 | 0.2 | 0.3 | -0.3 |
| Pavlov. Cond. magazine entry latency | 0.0 | 0.0 | 0.2 | 0.2 | 0.1 | 0.1 | 0.1 | 0.2 | -0.4 |
| Bone: tissue strength | 0.0 | 0.0 | 0.1 | -0.3 | -0.2 | -0.1 | -0.1 | -0.2 | 0.3 |
| Delta distance traveled before/after self-admin | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | -0.1 | 0.1 | -0.0 | 0.1 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.