Pdzd8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	ENSRNOG00000009460	0.04	0.02	2.3e-03	0	0	0	-0	3.0e-01	7.6e-02	1.3e-01	4.1e-01
2	Brain	mRNA stability	ENSRNOG00000009460	0.09	0.07	4.4e-06	0.07	0.05	0.05	0.06	5.8e-07	9.7e-06	1.6e-05	2.3e-06
3	LHb	gene expression	ENSRNOG00000009460	0.46	0.14	1.4e-07	0.21	0.26	0.27	0.29	8.2e-06	8.7e-07	4.4e-07	1.4e-07
4	Liver	gene expression	ENSRNOG00000009460	0.02	0.01	8.6e-03	0.01	0.01	0.01	0.01	1.0e-02	4.9e-02	6.4e-02	6.5e-02
5	Liver	intron excision ratio	chr1:258458186:258476751	0.04	0.02	6.9e-04	0.02	0.02	0.01	0.02	3.0e-03	3.7e-03	1.3e-02	3.9e-03
6	Liver	intron excision ratio	chr1:258476140:258476751	0.04	0.03	2.3e-03	0.02	0.02	0	0.02	2.6e-03	6.6e-03	1.0e-01	5.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
BMI with tail	3.2	10.5	48.9	7.0	2.6	0.6	2.5	-0.0	-0.1
BMI without tail	2.5	5.2	23.0	4.8	2.1	-0.2	1.9	-0.0	0.1
Body weight	3.4	14.4	65.2	8.1	3.3	0.2	3.2	-0.0	-0.1
Epididymis fat weight	4.8	11.3	54.7	7.4	2.0	1.2	1.9	-1.4	1.4
Glucose	1.3	2.0	8.5	2.9	1.2	-0.5	1.4	0.0	-0.0
Heart weight	0.7	0.9	4.4	2.1	0.6	0.7	0.6	0.1	-0.1
Left kidney weight	0.4	1.1	3.6	1.1	-0.2	1.9	-0.2	0.9	-0.9
Right kidney weight	0.5	1.3	2.8	1.7	0.5	1.5	0.4	1.1	-1.2
Tail length	0.2	0.7	2.0	1.4	0.8	-0.8	0.8	-0.2	0.2
Length with tail	0.4	1.4	6.6	2.6	1.0	0.0	1.0	-0.2	0.1
Length without tail	0.5	1.1	4.3	2.1	-0.0	1.3	0.0	-0.6	0.4
Liver weight, left	2.2	3.6	11.9	3.5	2.0	-1.2	1.9	0.4	-0.5
Liver weight, right	3.3	5.5	16.5	4.1	2.6	-1.5	2.5	0.7	-0.8
Parametrial fat weight	3.9	7.6	35.5	6.0	2.0	0.2	1.9	-1.2	1.2
Retroperitoneal fat weight	5.0	16.7	80.2	9.0	2.8	1.4	2.7	-1.1	1.1
Intraocular pressure	0.9	1.2	2.8	1.5	-0.1	0.7	0.1	-1.4	1.7
Extensor digitorum longus weight	0.8	3.1	11.2	3.3	1.8	-0.4	2.0	0.2	-0.2
Soleus weight	4.8	13.9	18.7	3.1	4.3	-3.4	4.3	3.6	-3.5
Tibialis anterior weight	1.2	4.0	6.4	2.3	2.4	-1.9	2.5	1.2	-1.2
Tibia length	0.1	0.3	0.9	0.3	-0.6	0.9	-0.4	-0.4	0.4
Number of licking bursts	2.2	2.6	4.3	0.1	-1.6	1.6	-1.7	-2.1	1.9
Food consumed during 24 hour testing period	0.7	0.8	1.5	-0.7	-1.2	0.9	-1.1	-0.7	0.7
Times rat made contact with spout	0.0	0.0	0.1	0.2	-0.2	0.2	-0.3	-0.3	0.1
Mean time between licks in bursts	0.5	0.7	2.0	0.2	-0.5	0.2	-0.5	-1.3	1.4
Mean num. licks in bursts	2.1	2.5	4.4	-0.0	1.5	-1.5	1.5	2.1	-2.0
Std. dev. time between licks in bursts	2.2	2.7	3.3	-1.1	-1.8	1.5	-1.8	-1.7	1.8
Water consumed over 24 hours	0.2	0.2	0.7	-0.8	-0.3	-0.0	-0.3	0.4	-0.5
Indifference point 0 sec	0.7	1.2	4.5	2.1	-0.2	1.2	0.3	-0.7	0.9
Indifference point AUC	0.3	0.4	1.8	1.4	0.2	-0.1	0.4	-0.4	0.5
Indifference point function ln k	0.2	0.2	0.6	-0.8	-0.4	0.7	-0.3	0.2	-0.1
Indifference point function log k	0.2	0.2	0.6	-0.8	-0.4	0.7	-0.3	0.2	-0.1
Delay discounting total patch changes 0 sec	0.9	1.5	5.5	2.4	-0.2	1.3	0.3	-0.8	1.0
Delay discounting total patch changes 12 sec	1.1	1.5	5.1	2.3	-0.2	0.9	0.1	-1.1	1.3
Delay discounting total patch changes 18 sec	1.0	1.3	5.6	2.4	0.4	0.1	0.8	-0.7	0.8
Delay discounting total patch changes 24 sec	0.9	1.1	3.7	1.9	0.0	0.4	0.4	-1.1	1.3
Delay discounting total patch changes 6 sec	1.5	2.2	6.3	2.5	-0.4	1.4	-0.1	-1.5	1.7
Delay discounting time to switch 0 sec	0.5	0.7	1.5	-1.0	0.5	-1.2	0.5	0.8	-0.8
Delay discounting water rate 0 sec	0.5	0.8	2.4	1.5	-0.2	1.3	-0.1	-0.5	0.5
Delay discounting water rate 12 sec	0.8	1.2	2.7	1.6	-0.3	1.2	-0.3	-1.3	1.1
Delay discounting water rate 18 sec	0.1	0.1	0.1	0.3	0.1	0.4	0.1	0.4	-0.3
Delay discounting water rate 24 sec	0.7	0.9	1.3	1.1	1.0	-0.1	1.0	1.1	-1.0
Delay discounting water rate 6 sec	0.2	0.2	0.7	0.8	0.4	0.2	0.4	0.4	-0.5
Locomotor activity	0.1	0.1	0.2	-0.1	0.4	-0.3	0.4	0.3	-0.3
Locomotor testing distance	0.3	0.6	1.1	-0.9	0.4	-0.5	0.4	1.0	-1.0
Locomotor testing rearing	1.0	1.6	2.4	-0.1	1.3	-1.3	1.3	1.5	-1.4
Light reinforcement 1	0.2	0.3	0.8	-0.9	-0.5	0.5	-0.6	0.3	-0.2
Light reinforcement 2	0.5	0.7	1.9	-1.4	-0.9	0.5	-1.1	-0.1	0.1
Reaction time number correct	1.3	1.9	3.0	1.0	1.7	-1.6	1.6	0.9	-1.2
Reaction time mean minus median	2.2	2.9	4.6	1.5	2.1	-1.7	2.0	1.3	-1.4
Reaction time mean minus median AUC	5.6	7.1	9.4	1.3	3.1	-2.9	2.9	2.6	-2.8
Reaction time num false alarms	0.2	0.3	0.9	-0.3	-0.6	0.9	-0.7	-0.1	0.2
Reaction time num false alarms AUC	0.1	0.1	0.4	-0.2	-0.2	0.6	-0.3	0.3	-0.2
Reaction time trials correct on left	1.3	1.9	3.0	1.0	1.7	-1.6	1.6	0.9	-1.2
Reaction time trials on left	1.5	2.2	3.4	1.1	1.9	-1.7	1.7	1.0	-1.3
Reaction time mean	4.3	5.9	8.5	0.8	2.8	-2.9	2.7	2.3	-2.4
Reaction time mean AUC	5.3	7.1	10.3	0.8	3.0	-3.2	2.9	2.6	-2.7
Median of all reaction times	4.6	6.2	9.0	0.4	2.7	-3.0	2.7	2.6	-2.7
Reaction time omissions	1.8	2.4	4.1	1.6	2.0	-1.6	1.9	0.9	-0.9
Reaction time false alarm rate	0.9	1.3	2.6	-0.6	-1.4	1.6	-1.4	-0.6	0.8
Reaction time premature initiation rate	0.1	0.1	0.3	-0.0	0.1	0.4	0.0	0.5	-0.6
Reaction time premature initiations	0.6	0.9	1.6	0.6	1.1	-0.5	0.9	1.0	-1.3
Std. dev. reaction times	3.2	4.4	6.8	1.8	2.6	-2.2	2.5	1.6	-1.8
Reaction time trials completed	1.5	2.2	3.4	1.1	1.9	-1.7	1.7	1.0	-1.3
Reaction time trials AUC	1.4	2.0	3.1	1.1	1.8	-1.6	1.6	0.9	-1.2
Social response proportion	0.5	0.5	1.2	0.4	0.8	-0.2	0.8	1.1	-0.9
Social responses	0.4	0.5	2.5	1.6	0.5	0.5	0.5	-0.3	0.3
Social time	2.5	3.2	4.3	0.6	2.0	-1.8	2.1	2.1	-1.8
Conditioned locomotion	0.3	0.4	0.6	0.0	0.6	-0.8	0.8	0.6	-0.5
Cocaine response after cond. corrected	1.7	1.9	7.6	-2.8	-0.6	-0.2	-0.6	1.3	-1.1
Cocaine response after cond. not corrected	1.5	1.7	7.7	-2.8	-0.8	-0.2	-0.7	0.8	-0.8
Cocaine response before conditioning	0.4	0.5	1.5	0.5	-0.4	0.3	-0.3	-1.2	1.0
Saline control response	0.3	0.4	0.8	-0.2	0.6	-0.6	0.7	0.9	-0.7
Condit. Reinf. active minus inactive responses	0.7	0.8	3.1	1.8	0.4	0.1	0.3	-0.9	0.9
Condit. Reinf. active-inactive response ratio	0.5	0.5	2.2	1.5	0.4	0.0	0.4	-0.4	0.5
Condit. Reinf. active responses	1.0	1.4	5.6	2.4	0.5	0.2	0.5	-1.1	1.1
Condit. Reinf. inactive responses	0.4	0.5	2.1	1.4	0.5	0.0	0.4	-0.5	0.5
Condit. Reinf. lever presses	0.4	0.6	2.4	1.6	-0.0	0.4	0.1	-0.7	0.8
Condit. Reinf. lever reinforcers received	0.8	1.1	3.3	1.8	0.1	0.5	0.0	-1.2	1.3
Pavlov. Cond. lever latency	0.7	1.0	1.8	-1.3	0.3	-0.6	0.3	1.3	-1.4
Pavlov. Cond. magazine entry latency	0.5	0.5	0.9	0.9	0.8	-1.0	0.9	0.2	-0.2
Pavlov. Cond. change in total contacts	0.2	0.3	1.1	1.0	0.2	-0.2	0.2	-0.6	0.6
Pavlov. Cond. index score	0.3	0.4	1.7	1.3	0.4	-0.3	0.4	-0.5	0.5
Pavlov. Cond. latency score	0.3	0.4	1.3	1.1	0.3	-0.2	0.3	-0.6	0.6
Pavlov. Cond. lever contacts	0.3	0.5	1.3	1.2	-0.1	0.2	-0.1	-0.8	0.8
Pavlov. Cond. magazine entry number	0.3	0.3	0.7	-0.8	-0.6	0.7	-0.6	-0.1	0.1
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.1	1.1	-0.1	0.7	-0.1	-0.5	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	1.3	1.2	0.4	-0.4	0.4	-0.3	0.3
Pavlov. Cond. response bias	0.4	0.5	1.5	1.2	0.1	0.0	0.0	-0.9	0.9
Conditioned reinforcement - actives	1.3	1.3	5.2	-2.3	-1.1	-0.3	-1.0	0.3	-0.4
Conditioned reinforcement - inactives	0.1	0.2	0.4	0.4	0.1	-0.4	-0.1	-0.6	0.5
Conditioned locomotion	1.3	1.6	5.7	-2.4	-1.4	0.3	-1.3	0.2	-0.1
Intermittent access intake day 1-15 change	1.3	1.3	2.5	1.0	1.5	-1.3	1.6	0.5	-0.5
Intermittent access intake escalation	1.1	1.0	1.6	0.1	1.2	-1.0	1.3	1.1	-1.1
Intermittent access intake escalation 2	0.6	0.6	1.1	0.2	1.0	-0.9	1.0	0.6	-0.8
Intermitt. access day 1 inactive lever presses	1.7	1.9	4.9	2.2	1.5	-1.0	1.5	-0.5	0.8
Intermitt. access day 15 inactive lever presses	0.4	0.5	1.4	1.2	0.8	-0.3	0.9	0.3	0.1
Intermitt. access escalation Index	0.6	0.6	0.9	0.3	0.9	-1.0	0.9	0.7	-0.6
Intermittent access day 1 total infusions	0.0	0.1	0.2	-0.4	0.0	-0.2	-0.1	0.1	-0.4
Intermittent access day 15 total infusions	0.9	1.0	1.5	-0.0	1.2	-1.2	1.1	1.0	-1.1
Intermittent access terminal intake (last 3 days)	0.5	0.6	0.9	0.3	1.0	-0.9	0.8	0.5	-0.8
Intermittent access total infusions	0.3	0.3	0.6	-0.3	0.6	-0.7	0.4	0.5	-0.8
Intermittent access day 1 locomotion	1.0	1.0	1.8	-0.9	0.6	-0.9	0.6	1.3	-1.3
Intermittent access day 15 total locomotion	0.8	0.8	1.6	1.3	1.2	-0.7	1.2	0.2	-0.1
Intermittent access total locomotion	0.7	0.8	1.6	-0.6	0.6	-0.7	0.7	1.3	-1.2
Intermittent access standard deviation	0.3	0.4	0.7	0.5	0.7	-0.9	0.7	-0.3	0.0
Cocaine induced anxiety	3.2	3.6	7.4	-2.7	-2.3	1.5	-2.3	-0.8	0.7
Post-drug Anxiety	1.4	1.6	2.2	-1.3	-1.5	1.5	-1.5	-0.8	0.7
Baseline Anxiety	2.0	2.1	6.0	2.4	1.7	-0.9	1.7	-0.0	0.2
Lifetime Intake	0.1	0.2	0.4	-0.6	0.2	-0.3	-0.0	0.3	-0.6
Incentive Sensitization - Responses	4.3	4.3	6.9	2.2	2.6	-2.0	2.6	1.4	-1.4
Incentive Sensitization - Breakpoint	4.1	4.1	6.7	2.3	2.5	-1.9	2.6	1.2	-1.2
Progressive ratio test 1 active lever presses	0.9	0.9	1.7	-0.1	1.1	-1.3	0.8	0.7	-1.1
Progressive ratio test 1 breakpoint	0.5	0.5	1.1	-0.2	0.8	-1.0	0.5	0.5	-0.9
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	0.2	0.2	-0.3	0.1	-0.4	0.4
Progressive ratio test 2 active lever presses	2.3	2.4	3.6	1.2	1.9	-1.6	1.8	1.2	-1.5
Progressive ratio test 2 breakpoint	2.8	3.1	4.8	1.5	2.2	-1.8	2.1	1.3	-1.6
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.5	0.5	-0.1	0.1	-0.2	-0.7	0.6
Total sessions with >9 infusions	0.2	0.2	0.5	-0.7	0.2	-0.1	-0.0	0.7	-0.7
Short access day 1 total inactive lever presses	0.5	0.6	1.2	-0.0	-0.6	0.7	-0.8	-1.1	0.8
Short access day 10 total inactive lever presses	0.4	0.4	1.8	1.3	0.4	0.3	0.4	-0.4	0.5
Short access day 1 total infusions	0.2	0.2	0.5	-0.0	0.6	-0.3	0.3	0.5	-0.7
Short access day 10 total infusions	0.5	0.5	1.4	-1.2	0.2	-0.6	0.0	0.7	-0.9
Short access total infusions	0.3	0.3	0.9	-1.0	0.0	-0.2	-0.2	0.5	-0.7
Short access day 1 locomotion	0.7	0.8	1.7	0.5	1.1	-1.3	0.9	0.7	-0.5
Short access day 10 total locomotion	0.4	0.5	1.0	-0.3	0.5	-0.5	0.6	1.0	-0.9
Short access total locomotion	1.5	1.5	3.2	-1.0	0.6	-1.0	0.6	1.8	-1.8
Compulsive drug intake	0.2	0.2	0.8	0.4	-0.0	0.4	-0.1	-0.5	0.9
One hour access (0.3 mA shock)	0.6	0.7	1.8	0.7	1.0	-1.3	1.0	-0.2	0.1
One hour access (shock baseline)	0.2	0.2	0.7	-0.3	0.4	-0.8	0.4	0.2	-0.5
Number of responses in last shaping day	0.0	0.0	0.0	-0.0	0.1	-0.1	-0.2	-0.1	0.1
Context. condit. distance diff. score	0.6	0.7	1.2	-0.7	-1.1	1.1	-1.1	-0.5	0.4
Locomotion velocity, session 1	0.1	0.1	0.4	-0.7	-0.2	0.0	-0.2	-0.1	0.2
Locomotion distance, session 1	0.5	0.7	2.6	-1.6	-0.7	0.4	-0.8	0.3	-0.2
Locomotion velocity, session 2	1.2	1.4	4.8	-2.2	-1.2	0.7	-1.2	0.2	-0.2
Locomotion distance, session 2	0.3	0.5	0.9	-0.8	-0.7	1.0	-0.9	0.1	-0.1
Locomotion velocity, session 3	0.4	0.5	1.8	-1.4	-0.7	0.4	-0.7	0.2	-0.3
Locomotion distance, session 3	0.6	0.7	2.2	-1.5	-0.7	0.5	-0.7	0.6	-0.7
Stereotopy head waving bouts, day 3	0.3	0.3	0.6	-0.4	0.5	-0.8	0.4	0.6	-0.6
Stereotopy head waving duration, day 3	0.0	0.1	0.2	-0.3	0.1	-0.4	0.0	-0.1	0.1
Locomotion velocity, session 7	0.6	0.7	1.7	-0.3	-1.0	1.3	-1.0	-0.5	0.5
Locomotion distance, session 7	0.4	0.5	1.2	-0.5	-0.8	1.1	-0.8	-0.0	-0.0
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	0.4	-0.1	0.1	-0.1	-0.5	0.5
Stereotopy head waving duration, day 7	0.7	0.8	1.2	1.1	1.1	-1.1	1.1	0.3	-0.2
Locomotion velocity, session 8	2.6	3.1	4.4	-1.6	-2.1	1.7	-2.1	-1.5	1.4
Locomotion distance, session 8	3.9	5.9	9.0	-2.3	-2.9	2.8	-3.0	-1.5	1.5
Degree of sensitization distance	0.4	0.4	1.0	1.0	-0.1	0.4	-0.0	-0.7	0.7
Degree of sensitization stereotypy	0.3	0.3	1.3	1.1	0.3	0.1	0.3	-0.4	0.4
Condit. Reinf. active minus inactive responses	1.4	1.6	2.1	-1.1	-1.5	1.4	-1.5	-1.1	1.1
Condit. Reinf. active-inactive response ratio	0.7	0.8	1.0	-1.0	-1.0	0.7	-1.0	-0.9	0.8
Condit. Reinf. active responses	2.1	2.5	4.8	-0.1	-1.6	2.2	-1.6	-1.6	1.6
Condit. Reinf. inactive responses	2.0	2.3	4.9	0.7	-1.3	2.2	-1.4	-1.6	1.6
Incentive salience index mean	1.3	1.6	2.3	-1.2	-1.5	1.5	-1.5	-0.8	0.8
Condit. Reinf. lever presses	0.3	0.3	0.7	-0.6	-0.7	0.9	-0.7	-0.2	0.1
Time in familiar zone, hab. session 1	1.6	1.6	2.0	1.0	1.4	-1.0	1.4	1.3	-1.3
Time in novel zone, hab. session 1	1.2	1.2	2.2	-0.5	-1.0	0.7	-1.0	-1.5	1.4
Total zone transitions, hab. session 1	0.2	0.2	0.4	0.5	0.5	-0.1	0.5	0.6	-0.5
Total locomotion distance, hab. session 1	1.4	2.0	2.8	-0.2	-1.4	1.6	-1.5	-1.6	1.7
Locomotion velocity, hab. session 1	1.3	1.8	2.3	-0.3	-1.4	1.5	-1.5	-1.5	1.5
Time in familiar zone, hab. session 2	0.4	0.4	0.8	0.9	0.2	-0.1	0.2	-0.8	0.8
Time in novel zone, hab. session 2	0.3	0.3	0.6	-0.8	-0.2	0.1	-0.1	0.7	-0.7
Total zone transitions, hab. session 2	0.5	0.6	0.9	0.3	0.8	-0.8	0.8	0.9	-0.8
Total locomotion distance, hab. session 2	0.1	0.1	0.2	0.4	-0.2	0.5	-0.2	-0.3	0.3
Locomotion velocity, hab. session 2	0.0	0.1	0.3	0.5	0.1	0.2	0.1	-0.0	0.1
Novel to familiar place preference ratio	1.9	2.0	3.0	-0.2	-1.4	1.4	-1.3	-1.7	1.7
Novelty place preference	1.4	1.4	2.2	-0.3	-1.2	1.1	-1.1	-1.5	1.5
Time in novel zone, NPP test	1.6	1.7	3.1	0.2	-1.1	1.2	-1.1	-1.7	1.7
Total zone transitions, NPP test	0.0	0.1	0.1	0.2	0.3	-0.0	0.2	0.3	-0.3
Total locomotion distance, NPP test	1.1	1.5	2.5	-0.4	-1.3	1.6	-1.4	-1.0	1.1
Locomotion velocity, NPP test	1.1	1.6	2.5	-1.0	-1.5	1.6	-1.6	-0.8	0.9
Pavlov. Cond. lever latency	0.1	0.1	0.3	0.1	0.2	-0.5	0.2	-0.4	0.5
Pavlov. Cond. magazine entry latency	0.0	0.0	0.2	0.2	0.1	0.1	0.1	0.2	-0.4
Pavlov. Cond. change in total contacts	0.4	0.5	0.7	0.8	0.7	-0.3	0.7	0.7	-0.7
Pavlov. Cond. index score	0.2	0.2	0.3	0.6	0.4	-0.1	0.4	0.5	-0.6
Pavlov. Cond. latency score	0.1	0.1	0.3	0.4	0.3	-0.0	0.3	0.4	-0.5
Pavlov. Cond. lever contacts	0.1	0.2	0.3	0.5	0.3	-0.0	0.3	0.4	-0.5
Pavlov. Cond. magazine entry number	0.4	0.5	0.6	-0.7	-0.8	0.6	-0.7	-0.6	0.7
Pavlov. Cond. intertrial magazine entries	1.2	1.5	3.6	0.0	-1.3	1.9	-1.3	-0.9	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.4	0.7	0.4	-0.1	0.4	0.4	-0.5
Pavlov. Cond. response bias	0.2	0.2	0.5	0.3	0.4	-0.2	0.4	0.6	-0.7
Bone: apparent density	1.4	2.2	4.1	2.0	-0.5	1.5	-0.6	-1.8	1.9
Bone surface	1.2	2.1	2.9	1.5	-0.8	1.7	-0.9	-1.7	1.7
Bone volume	0.9	1.5	5.9	2.4	0.1	1.0	0.0	-1.0	1.1
Bone: connectivity density	1.1	1.7	2.9	0.9	-0.9	1.5	-1.0	-1.7	1.7
Bone: cortical apparent density	1.5	2.0	8.2	-2.9	-0.5	-0.4	-0.5	1.3	-1.2
Bone: cortical area	1.8	2.7	7.2	2.7	-0.6	1.9	-0.6	-1.6	1.5
Bone: cortical porosity	0.3	0.3	1.4	1.2	0.2	0.1	0.2	-0.6	0.5
Bone: cortical porosity	0.6	0.7	2.9	1.7	0.5	-0.0	0.5	-0.6	0.6
Bone: cortical thickness	1.6	2.7	7.0	1.3	-1.4	2.6	-1.4	-1.4	1.3
Bone: cortical thickness	0.3	0.3	1.2	1.1	-0.0	0.9	-0.1	0.0	-0.1
Bone: cortical tissue density	1.7	2.2	8.7	-3.0	-0.5	-0.5	-0.5	1.4	-1.3
Bone: elastic displacement	1.0	1.1	1.6	0.2	1.1	-1.0	1.1	1.2	-1.3
Bone: elastic work	0.9	1.2	2.6	0.4	0.8	-0.5	1.0	1.6	-1.6
Bone: endosteal estimation	0.2	0.5	2.6	1.6	0.5	0.0	0.4	-0.4	0.3
Bone: endosteal perimeter	1.0	2.0	5.8	2.4	1.5	-0.9	1.5	0.5	-0.5
Bone: final force	0.8	1.4	3.6	1.9	-0.5	1.6	-0.5	-0.9	0.8
Bone: final moment	0.8	1.3	3.9	2.0	-0.4	1.5	-0.4	-0.8	0.8
Bone: marrow area	0.3	0.6	2.8	1.7	0.5	0.1	0.4	-0.4	0.4
Bone: maximum diameter	1.2	2.1	10.0	3.2	0.8	0.2	0.8	-1.0	0.9
Bone: maximum force	1.1	1.9	4.2	1.4	-1.1	2.1	-1.0	-1.2	1.1
Bone: maximum moment	1.0	1.8	3.9	1.4	-1.0	2.0	-1.0	-1.2	1.2
Bone: minimum diameter	0.7	1.3	5.6	2.4	0.1	1.0	0.1	-0.8	0.7
Bone: periosteal estimation	0.8	1.7	6.2	2.5	-0.2	1.3	-0.2	-1.1	1.0
Bone: periosteal perimeter	1.6	2.7	11.6	3.4	1.5	-0.4	1.4	0.2	-0.3
Bone: post-yield work	3.1	4.2	6.0	0.4	-1.9	2.4	-2.0	-2.4	2.4
Bone: stiffness	1.3	2.0	3.9	0.7	-1.4	2.0	-1.3	-1.4	1.4
Bone: tissue strength	0.0	0.0	0.1	-0.3	-0.2	-0.1	-0.1	-0.2	0.3
Bone: trabecular number	1.4	2.1	3.6	1.7	-0.6	1.4	-0.7	-1.8	1.9
Bone: trabecular spacing	0.2	0.3	1.5	-1.2	-0.1	-0.6	-0.1	0.2	-0.2
Bone: trabecular thickness	1.4	1.7	8.5	2.9	0.6	0.6	0.7	-0.7	0.6
Bone: trabecular tissue density	1.6	2.3	3.9	-1.3	0.9	-1.7	1.1	2.0	-1.8
Breakpoint value in progressive ratio session	1.3	1.4	3.7	1.9	1.3	-1.0	1.3	-0.5	0.5
Distance traveled before self-admin	2.3	2.5	4.9	-1.3	1.0	-1.5	1.0	2.2	-2.1
Distance traveled after self-admin	0.9	1.0	2.0	-1.2	0.5	-1.1	0.5	1.4	-1.2
Delta time in closed arm before/after self-admin	0.5	0.5	1.6	-1.3	-0.7	0.6	-0.7	0.1	-0.2
Delta time in open arm before/after self-admin	0.8	0.7	2.0	0.9	-0.0	-0.0	-0.0	-1.4	1.3
Diff in mean of infusions in LGA sessions	0.5	0.5	1.5	1.2	0.4	-0.5	0.5	-0.8	0.7
Extinction: sum of active levers before priming	1.3	1.3	2.2	1.2	1.5	-1.3	1.5	0.2	-0.4
Active lever presses in extinction session 6	0.9	0.9	1.7	1.3	1.2	-0.8	1.2	0.2	-0.4
Delta distance traveled before/after self-admin	0.0	0.0	0.0	0.1	0.1	-0.1	0.1	-0.0	0.1
Delta ambulatory time before/after self-admin	0.1	0.2	0.4	0.3	-0.2	0.2	-0.2	-0.5	0.6
Time in closed arm before self-admin	1.9	2.1	3.0	0.8	1.7	-1.5	1.7	1.5	-1.4
Time in closed arm after self-admin	1.7	1.7	2.9	-0.6	1.2	-1.3	1.2	1.7	-1.6
Time in open arm before self-admin	2.9	3.1	5.0	-1.7	-2.2	1.5	-2.2	-1.3	1.4
Time in open arm after self-admin	1.8	2.0	3.5	-0.2	-1.3	1.1	-1.3	-1.9	1.8
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.5	0.6	0.9	-1.2	0.9	-0.2	0.0
Time to tail flick, vehicle, before self-admin	1.7	1.8	2.4	0.4	-1.3	1.5	-1.3	-1.6	1.6
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.4	0.2	-0.2	0.7	-0.3	-0.3	0.3
Time to tail flick, test, before self-admin	0.5	0.5	1.1	-1.0	-0.2	-0.5	-0.2	0.9	-0.9
Time to tail flick, test, after self-admin	0.3	0.4	1.0	1.0	0.3	-0.1	0.3	-0.7	0.6
Delta time to tail flick, vehicle, before/after SA	1.1	1.1	1.7	1.0	1.3	-1.0	1.3	0.8	-0.8
Delta time to tail flick, test, before/after SA	1.2	1.0	2.1	1.1	-0.2	0.9	-0.2	-1.4	1.4
Ambulatory time before self-admin	1.3	1.3	2.6	-1.1	0.6	-1.0	0.6	1.6	-1.6
Ambulatory time after self-admin	0.8	0.9	1.4	-0.9	0.6	-1.2	0.6	1.2	-0.9
Total heroin consumption	1.4	1.7	6.0	2.5	1.2	-0.8	1.3	-0.4	0.3
Area under the delay curve	3.1	3.3	5.2	1.9	2.3	-1.8	2.2	1.3	-1.2
Delay disc. indifference point, 0s delay	0.2	0.2	0.6	0.2	0.4	-0.0	0.4	0.7	-0.7
Delay disc. indifference point, 16s delay	2.1	2.1	3.3	1.5	1.8	-1.4	1.7	1.1	-1.0
Delay disc. indifference point, 2s delay	2.6	2.9	3.8	0.3	1.9	-1.7	1.8	1.9	-1.9
Delay disc. indifference point, 24s delay	1.0	1.0	2.6	1.6	1.2	-0.8	1.1	0.2	-0.1
Delay disc. indifference point, 4s delay	2.0	2.1	3.1	1.2	1.7	-1.6	1.8	1.2	-1.2
Delay disc. indifference point, 8s delay	2.4	2.4	4.1	1.5	2.0	-1.6	1.9	1.1	-1.0
Delay discount exponential model param	3.7	3.9	6.0	-2.0	-2.5	2.0	-2.4	-1.4	1.4
Delay discount hyperbolic model param	3.6	3.8	5.9	-1.8	-2.4	2.0	-2.3	-1.5	1.5
Fecal boli incidents, locomotor time 1	0.2	0.2	0.4	0.2	-0.3	0.5	-0.4	-0.6	0.6
Change in fecal boli incidents, locomotor task	0.9	0.9	1.5	0.2	-0.9	1.2	-0.9	-0.9	1.1
Time >=10cm from walls, locomotor time 1	0.6	0.6	0.9	-0.5	-0.9	0.8	-0.9	-0.7	0.8
Bouts of movement, locomotor time 1	0.7	0.8	1.2	1.1	1.1	-1.1	1.0	-0.0	-0.2
Total resting periods, locomotor time 1	0.4	0.5	0.8	0.8	0.9	-0.9	0.8	0.1	-0.2
Rest time, locomotor task time 1	0.8	0.9	1.4	-1.1	-1.1	1.2	-1.2	-0.2	0.4
Distance moved, locomotor task time 1	0.6	0.7	1.0	0.6	0.9	-0.8	1.0	0.7	-0.8
Vertical activity count, locomotor time 1	0.4	0.4	0.9	0.2	0.6	-0.5	0.6	0.8	-0.9
Time >=10cm from walls, locomotor time 2	1.9	2.0	4.2	-0.3	-1.6	2.1	-1.6	-1.2	1.1
Bouts of movement, locomotor time 2	1.4	1.5	3.7	-0.3	1.3	-1.9	1.2	1.1	-1.0
Total resting periods, locomotor time 2	2.0	2.1	4.7	-0.1	1.7	-2.2	1.5	1.3	-1.2
Rest time, locomotor task time 2	0.5	0.6	0.9	-0.3	0.9	-1.0	0.8	1.0	-0.7
Distance moved, locomotor task time 2	0.6	0.7	1.5	-0.2	-1.0	1.2	-1.0	-0.7	0.5
Vertical activity count, locomotor time 2	0.9	0.9	1.7	-0.3	-1.1	1.3	-1.1	-0.9	0.7
Weight adjusted by age	0.8	0.9	2.6	1.6	1.1	0.3	1.1	0.5	-0.5
Seeking ratio, delayed vs. immediate footshock	1.3	1.5	4.8	-2.2	-1.5	0.5	-1.3	-0.3	0.2
Locomotion in novel chamber	0.2	0.2	0.5	-0.6	-0.3	0.0	-0.2	0.7	-0.6
Locomotion in novel chamber post-restriction	0.6	0.7	1.3	-1.2	-0.6	0.1	-0.5	1.0	-1.0
Progressive ratio	2.0	2.3	3.7	-1.8	-1.9	0.9	-1.8	-1.1	1.1
Food seeking constrained by brief footshock	0.3	0.4	1.5	-1.2	-0.7	0.0	-0.6	-0.2	0.2
Seeking ratio, punishment vs. effort	1.3	1.6	2.3	0.7	1.5	-0.9	1.5	1.4	-1.4
Run reversals in cocaine runway, females	0.1	0.1	0.3	0.6	0.2	-0.0	0.2	-0.4	0.5
Run reversals in cocaine runway, males	0.7	0.7	1.6	-0.8	0.4	-0.4	0.4	1.1	-1.3
Latency to leave start box in cocaine runway	2.4	2.6	5.5	0.6	1.9	-2.4	1.9	1.0	-1.1
Latency to leave start box in cocaine runway, F	1.6	1.7	3.2	0.9	1.7	-1.8	1.7	0.7	-0.7
Latency to leave start box in cocaine runway, M	1.8	1.7	2.9	-0.1	1.3	-1.7	1.3	1.3	-1.3
Cd content in liver	4.9	5.3	7.8	-2.0	-2.8	2.2	-2.6	-2.0	2.2
Co content in liver	1.3	1.6	2.4	-1.3	-1.5	1.5	-1.6	-0.5	0.7
Cu content in liver	0.1	0.1	0.2	-0.2	-0.1	-0.3	0.1	0.5	-0.4
Fe content in liver	1.2	1.5	2.3	0.2	-1.2	1.5	-0.9	-1.5	1.5
K content in liver	0.6	0.6	1.5	0.3	0.8	-1.2	0.9	0.7	-0.7
Mg content in liver	2.6	2.6	4.3	0.9	1.7	-2.1	1.9	1.4	-1.4
Mn content in liver	0.5	0.6	0.9	0.5	0.8	-0.7	1.0	0.8	-0.7
Na content in liver	2.4	2.6	3.7	1.7	1.9	-1.7	1.8	1.1	-1.2
Rb content in liver	1.4	1.7	3.2	0.6	1.5	-1.8	1.6	1.0	-0.9
Se content in liver	0.9	1.1	1.6	-0.2	-1.2	1.1	-0.8	-1.3	1.2
Sr content in liver	0.9	0.8	3.3	-1.8	-0.3	-0.4	0.1	0.9	-0.7
Zn content in liver	2.7	3.0	5.8	-0.8	1.3	-1.6	1.3	2.4	-2.4