Hub : Genes

Mgme1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	isoform ratio	ENSRNOT00000038865	0.03	0.02	6.6e-03	0.02	0.01	0.01	0.01	4.0e-03	5.0e-02	7.1e-02	1.7e-02
2	Liver	isoform ratio	ENSRNOT00000098696	0.03	0.02	5.3e-03	0.02	0.01	0.01	0.01	3.2e-03	4.2e-02	5.6e-02	1.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	9.7	31.3	31.3	-5.6	5.6
BMI without tail	6.9	14.4	14.4	-3.8	3.8
Body weight	10.9	46.3	46.3	-6.8	6.8
Epididymis fat weight	7.4	17.3	17.3	-4.2	4.2
Glucose	0.7	1.0	1.0	-1.0	1.0
Heart weight	1.1	1.6	1.6	-1.2	1.2
Left kidney weight	1.4	4.0	4.0	-2.0	2.0
Right kidney weight	1.1	3.2	3.2	-1.8	1.8
Tail length	0.1	0.2	0.2	-0.4	0.4
Length with tail	1.3	4.9	4.9	-2.2	2.2
Length without tail	1.9	4.0	4.0	-2.0	2.0
Liver weight, left	0.2	0.3	0.3	-0.6	0.6
Liver weight, right	0.5	0.7	0.7	-0.9	0.9
Parametrial fat weight	14.7	28.7	28.7	-5.4	5.4
Retroperitoneal fat weight	20.3	67.0	67.0	-8.2	8.2
Intraocular pressure	0.3	0.4	0.4	0.7	-0.7
Extensor digitorum longus weight	0.3	1.1	1.1	-1.0	1.0
Soleus weight	0.2	0.7	0.7	-0.8	0.8
Tibialis anterior weight	1.3	4.6	4.6	-2.1	2.1
Tibia length	2.4	6.9	6.9	-2.6	2.6
Number of licking bursts	0.0	0.1	0.1	-0.2	0.2
Food consumed during 24 hour testing period	0.5	0.6	0.6	-0.8	0.8
Times rat made contact with spout	1.9	2.2	2.2	-1.5	1.5
Mean time between licks in bursts	0.3	0.5	0.5	0.7	-0.7
Mean num. licks in bursts	0.3	0.3	0.3	-0.6	0.6
Std. dev. time between licks in bursts	0.9	1.1	1.1	1.0	-1.0
Water consumed over 24 hours	0.0	0.0	0.0	0.1	-0.1
Indifference point 0 sec	1.0	1.7	1.7	1.3	-1.3
Indifference point AUC	0.7	0.8	0.8	0.9	-0.9
Indifference point function ln k	0.0	0.0	0.0	-0.0	0.0
Indifference point function log k	0.0	0.0	0.0	-0.0	0.0
Delay discounting total patch changes 0 sec	1.4	2.3	2.3	1.5	-1.5
Delay discounting total patch changes 12 sec	0.0	0.0	0.0	-0.2	0.2
Delay discounting total patch changes 18 sec	2.3	3.1	3.1	1.8	-1.8
Delay discounting total patch changes 24 sec	0.6	0.8	0.8	0.9	-0.9
Delay discounting total patch changes 6 sec	0.4	0.7	0.7	0.8	-0.8
Delay discounting time to switch 0 sec	3.0	4.6	4.6	-2.1	2.1
Delay discounting water rate 0 sec	3.1	4.9	4.9	2.2	-2.2
Delay discounting water rate 12 sec	3.3	4.9	4.9	2.2	-2.2
Delay discounting water rate 18 sec	8.1	10.7	10.7	3.3	-3.3
Delay discounting water rate 24 sec	5.2	7.1	7.1	2.7	-2.7
Delay discounting water rate 6 sec	4.2	6.2	6.2	2.5	-2.5
Locomotor activity	0.2	0.3	0.3	-0.6	0.6
Locomotor testing distance	0.1	0.2	0.2	0.4	-0.4
Locomotor testing rearing	0.1	0.1	0.1	0.3	-0.3
Light reinforcement 1	0.7	1.3	1.3	1.1	-1.1
Light reinforcement 2	0.8	1.1	1.1	1.0	-1.0
Reaction time number correct	0.9	1.2	1.2	1.1	-1.1
Reaction time mean minus median	0.7	0.9	0.9	-0.9	0.9
Reaction time mean minus median AUC	0.4	0.6	0.6	-0.7	0.7
Reaction time num false alarms	1.9	2.7	2.7	1.6	-1.6
Reaction time num false alarms AUC	1.5	2.2	2.2	1.5	-1.5
Reaction time trials correct on left	0.9	1.2	1.2	1.1	-1.1
Reaction time trials on left	0.8	1.2	1.2	1.1	-1.1
Reaction time mean	2.8	3.8	3.8	-2.0	2.0
Reaction time mean AUC	2.7	3.6	3.6	-1.9	1.9
Median of all reaction times	3.0	4.0	4.0	-2.0	2.0
Reaction time omissions	0.4	0.6	0.6	-0.8	0.8
Reaction time false alarm rate	0.6	0.8	0.8	0.9	-0.9
Reaction time premature initiation rate	0.2	0.2	0.2	0.5	-0.5
Reaction time premature initiations	0.8	1.1	1.1	1.0	-1.0
Std. dev. reaction times	1.4	1.9	1.9	-1.4	1.4
Reaction time trials completed	0.8	1.2	1.2	1.1	-1.1
Reaction time trials AUC	0.8	1.2	1.2	1.1	-1.1
Social response proportion	6.7	7.3	7.3	-2.7	2.7
Social responses	0.9	1.1	1.1	-1.1	1.1
Social time	2.0	2.7	2.7	-1.6	1.6
Conditioned locomotion	0.2	0.3	0.3	0.5	-0.5
Cocaine response after cond. corrected	2.1	2.4	2.4	1.5	-1.5
Cocaine response after cond. not corrected	3.2	3.5	3.5	1.9	-1.9
Cocaine response before conditioning	0.1	0.1	0.1	0.3	-0.3
Saline control response	0.0	0.0	0.0	-0.2	0.2
Condit. Reinf. active minus inactive responses	0.4	0.5	0.5	-0.7	0.7
Condit. Reinf. active-inactive response ratio	0.6	0.6	0.6	-0.8	0.8
Condit. Reinf. active responses	0.7	1.0	1.0	-1.0	1.0
Condit. Reinf. inactive responses	0.4	0.5	0.5	-0.7	0.7
Condit. Reinf. lever presses	2.6	3.5	3.5	-1.9	1.9
Condit. Reinf. lever reinforcers received	0.9	1.2	1.2	-1.1	1.1
Pavlov. Cond. lever latency	5.0	6.8	6.8	2.6	-2.6
Pavlov. Cond. magazine entry latency	0.8	0.9	0.9	-0.9	0.9
Pavlov. Cond. change in total contacts	4.5	6.3	6.3	-2.5	2.5
Pavlov. Cond. index score	4.5	5.9	5.9	-2.4	2.4
Pavlov. Cond. latency score	3.4	4.4	4.4	-2.1	2.1
Pavlov. Cond. lever contacts	4.4	6.1	6.1	-2.5	2.5
Pavlov. Cond. magazine entry number	2.2	2.7	2.7	1.6	-1.6
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.5	0.7	-0.7
Pavlov. Cond. lever-magazine prob. diff.	5.5	7.1	7.1	-2.7	2.7
Pavlov. Cond. response bias	3.6	4.9	4.9	-2.2	2.2
Conditioned reinforcement - actives	4.4	4.4	4.4	2.1	-2.1
Conditioned reinforcement - inactives	5.1	5.7	5.7	2.4	-2.4
Conditioned locomotion	1.9	2.3	2.3	1.5	-1.5
Intermittent access intake day 1-15 change	0.1	0.1	0.1	0.3	-0.3
Intermittent access intake escalation	0.1	0.1	0.1	0.3	-0.3
Intermittent access intake escalation 2	0.1	0.1	0.1	0.2	-0.2
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.1	-0.3	0.3
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.1	0.3	-0.3
Intermitt. access escalation Index	1.6	1.4	1.4	-1.2	1.2
Intermittent access day 1 total infusions	0.3	0.3	0.3	-0.6	0.6
Intermittent access day 15 total infusions	0.0	0.0	0.0	-0.1	0.1
Intermittent access terminal intake (last 3 days)	0.0	0.1	0.1	-0.2	0.2
Intermittent access total infusions	0.0	0.0	0.0	-0.2	0.2
Intermittent access day 1 locomotion	0.3	0.3	0.3	-0.5	0.5
Intermittent access day 15 total locomotion	0.1	0.1	0.1	0.4	-0.4
Intermittent access total locomotion	0.1	0.1	0.1	0.3	-0.3
Intermittent access standard deviation	0.7	0.7	0.7	0.9	-0.9
Cocaine induced anxiety	0.9	1.0	1.0	1.0	-1.0
Post-drug Anxiety	1.1	1.2	1.2	-1.1	1.1
Baseline Anxiety	4.3	4.5	4.5	-2.1	2.1
Lifetime Intake	0.1	0.1	0.1	0.3	-0.3
Incentive Sensitization - Responses	0.2	0.2	0.2	0.4	-0.4
Incentive Sensitization - Breakpoint	0.2	0.2	0.2	0.5	-0.5
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	-0.0	0.0
Progressive ratio test 1 breakpoint	0.1	0.1	0.1	-0.3	0.3
Progressive ratio test 1 inactive lever presses	0.4	0.4	0.4	0.7	-0.7
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	0.1	-0.1
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.1	0.1
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.0	0.2	-0.2
Total sessions with >9 infusions	0.0	0.0	0.0	0.2	-0.2
Short access day 1 total inactive lever presses	1.4	1.6	1.6	1.3	-1.3
Short access day 10 total inactive lever presses	0.4	0.4	0.4	-0.7	0.7
Short access day 1 total infusions	2.1	2.2	2.2	1.5	-1.5
Short access day 10 total infusions	0.0	0.0	0.0	-0.0	0.0
Short access total infusions	0.1	0.1	0.1	0.3	-0.3
Short access day 1 locomotion	0.3	0.4	0.4	0.6	-0.6
Short access day 10 total locomotion	0.3	0.3	0.3	0.6	-0.6
Short access total locomotion	0.2	0.2	0.2	0.4	-0.4
Compulsive drug intake	2.0	2.0	2.0	1.4	-1.4
One hour access (0.3 mA shock)	2.1	2.5	2.5	1.6	-1.6
One hour access (shock baseline)	0.0	0.1	0.1	-0.2	0.2
Number of responses in last shaping day	3.0	3.1	3.1	1.8	-1.8
Context. condit. distance diff. score	0.0	0.0	0.0	-0.2	0.2
Locomotion velocity, session 1	2.5	2.7	2.7	1.6	-1.6
Locomotion distance, session 1	5.3	6.8	6.8	2.6	-2.6
Locomotion velocity, session 2	2.1	2.5	2.5	1.6	-1.6
Locomotion distance, session 2	7.8	11.2	11.2	3.3	-3.3
Locomotion velocity, session 3	4.3	4.9	4.9	2.2	-2.2
Locomotion distance, session 3	1.4	1.5	1.5	1.2	-1.2
Stereotopy head waving bouts, day 3	0.0	0.0	0.0	0.1	-0.1
Stereotopy head waving duration, day 3	0.0	0.1	0.1	-0.2	0.2
Locomotion velocity, session 7	0.6	0.7	0.7	0.8	-0.8
Locomotion distance, session 7	0.1	0.1	0.1	0.4	-0.4
Stereotopy head waving bouts, day 7	0.1	0.1	0.1	-0.4	0.4
Stereotopy head waving duration, day 7	0.0	0.0	0.0	0.2	-0.2
Locomotion velocity, session 8	1.5	1.8	1.8	1.3	-1.3
Locomotion distance, session 8	3.5	5.2	5.2	2.3	-2.3
Degree of sensitization distance	0.7	0.7	0.7	-0.9	0.9
Degree of sensitization stereotypy	0.5	0.5	0.5	-0.7	0.7
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	0.2	-0.2
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.1	-0.1
Condit. Reinf. active responses	0.1	0.1	0.1	0.3	-0.3
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.1	-0.1
Incentive salience index mean	0.1	0.2	0.2	0.4	-0.4
Condit. Reinf. lever presses	0.0	0.0	0.0	-0.2	0.2
Time in familiar zone, hab. session 1	0.2	0.1	0.1	-0.4	0.4
Time in novel zone, hab. session 1	0.1	0.1	0.1	-0.3	0.3
Total zone transitions, hab. session 1	1.3	1.8	1.8	1.3	-1.3
Total locomotion distance, hab. session 1	1.4	2.1	2.1	1.4	-1.4
Locomotion velocity, hab. session 1	2.1	3.0	3.0	1.7	-1.7
Time in familiar zone, hab. session 2	1.2	1.2	1.2	1.1	-1.1
Time in novel zone, hab. session 2	1.9	2.0	2.0	-1.4	1.4
Total zone transitions, hab. session 2	0.4	0.5	0.5	0.7	-0.7
Total locomotion distance, hab. session 2	1.6	2.1	2.1	1.4	-1.4
Locomotion velocity, hab. session 2	2.4	3.2	3.2	1.8	-1.8
Novel to familiar place preference ratio	0.0	0.0	0.0	-0.2	0.2
Novelty place preference	0.1	0.1	0.1	-0.3	0.3
Time in novel zone, NPP test	0.3	0.4	0.4	-0.6	0.6
Total zone transitions, NPP test	1.1	1.6	1.6	1.2	-1.2
Total locomotion distance, NPP test	2.4	3.3	3.3	1.8	-1.8
Locomotion velocity, NPP test	3.1	4.4	4.4	2.1	-2.1
Pavlov. Cond. lever latency	0.1	0.2	0.2	-0.4	0.4
Pavlov. Cond. magazine entry latency	0.6	0.8	0.8	-0.9	0.9
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.2	-0.2
Pavlov. Cond. index score	0.1	0.1	0.1	-0.4	0.4
Pavlov. Cond. latency score	0.0	0.0	0.0	0.1	-0.1
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.2	0.2
Pavlov. Cond. magazine entry number	1.3	1.6	1.6	1.3	-1.3
Pavlov. Cond. intertrial magazine entries	3.5	4.2	4.2	2.0	-2.0
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.3	-0.6	0.6
Pavlov. Cond. response bias	0.8	0.9	0.9	-1.0	1.0
Bone: apparent density	0.0	0.0	0.0	-0.1	0.1
Bone surface	0.2	0.3	0.3	-0.6	0.6
Bone volume	0.1	0.1	0.1	-0.3	0.3
Bone: connectivity density	0.2	0.2	0.2	0.5	-0.5
Bone: cortical apparent density	0.0	0.0	0.0	-0.2	0.2
Bone: cortical area	0.7	1.0	1.0	-1.0	1.0
Bone: cortical porosity	0.2	0.2	0.2	-0.4	0.4
Bone: cortical porosity	0.4	0.5	0.5	-0.7	0.7
Bone: cortical thickness	0.7	1.1	1.1	-1.1	1.1
Bone: cortical thickness	0.0	0.0	0.0	0.2	-0.2
Bone: cortical tissue density	0.0	0.0	0.0	-0.1	0.1
Bone: elastic displacement	0.3	0.4	0.4	-0.6	0.6
Bone: elastic work	4.5	5.8	5.8	-2.4	2.4
Bone: endosteal estimation	1.7	3.8	3.8	-1.9	1.9
Bone: endosteal perimeter	0.0	0.0	0.0	-0.2	0.2
Bone: final force	1.4	2.3	2.3	-1.5	1.5
Bone: final moment	1.1	1.8	1.8	-1.3	1.3
Bone: marrow area	1.7	3.6	3.6	-1.9	1.9
Bone: maximum diameter	0.4	0.8	0.8	-0.9	0.9
Bone: maximum force	0.9	1.6	1.6	-1.3	1.3
Bone: maximum moment	0.8	1.4	1.4	-1.2	1.2
Bone: minimum diameter	0.7	1.3	1.3	-1.1	1.1
Bone: periosteal estimation	1.5	3.0	3.0	-1.7	1.7
Bone: periosteal perimeter	0.0	0.0	0.0	-0.2	0.2
Bone: post-yield work	0.0	0.0	0.0	0.1	-0.1
Bone: stiffness	0.2	0.3	0.3	-0.6	0.6
Bone: tissue strength	1.3	1.2	1.2	-1.1	1.1
Bone: trabecular number	0.1	0.1	0.1	0.3	-0.3
Bone: trabecular spacing	1.7	2.2	2.2	-1.5	1.5
Bone: trabecular thickness	0.0	0.0	0.0	-0.1	0.1
Bone: trabecular tissue density	0.6	0.9	0.9	-0.9	0.9
Breakpoint value in progressive ratio session	0.2	0.2	0.2	-0.4	0.4
Distance traveled before self-admin	0.2	0.2	0.2	-0.4	0.4
Distance traveled after self-admin	0.0	0.0	0.0	0.1	-0.1
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.3	-0.3
Delta time in open arm before/after self-admin	1.1	1.0	1.0	-1.0	1.0
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	-0.0	0.0
Extinction: sum of active levers before priming	0.0	0.0	0.0	0.2	-0.2
Active lever presses in extinction session 6	0.0	0.0	0.0	-0.2	0.2
Delta distance traveled before/after self-admin	0.0	0.0	0.0	0.1	-0.1
Delta ambulatory time before/after self-admin	0.0	0.0	0.0	0.2	-0.2
Time in closed arm before self-admin	0.0	0.0	0.0	0.2	-0.2
Time in closed arm after self-admin	1.0	1.0	1.0	1.0	-1.0
Time in open arm before self-admin	0.0	0.0	0.0	0.1	-0.1
Time in open arm after self-admin	0.9	1.0	1.0	-1.0	1.0
Sum of active levers in priming session hrs 5-6	1.6	1.6	1.6	1.2	-1.2
Time to tail flick, vehicle, before self-admin	1.1	1.1	1.1	-1.0	1.0
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	0.0	-0.0
Time to tail flick, test, before self-admin	1.2	1.2	1.2	1.1	-1.1
Time to tail flick, test, after self-admin	2.2	2.2	2.2	1.5	-1.5
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	0.9	1.0	-1.0
Delta time to tail flick, test, before/after SA	0.2	0.2	0.2	0.4	-0.4
Ambulatory time before self-admin	0.1	0.1	0.1	-0.3	0.3
Ambulatory time after self-admin	0.1	0.1	0.1	0.2	-0.2
Total heroin consumption	0.9	1.1	1.1	1.1	-1.1
Area under the delay curve	0.1	0.1	0.1	-0.3	0.3
Delay disc. indifference point, 0s delay	0.9	1.0	1.0	-1.0	1.0
Delay disc. indifference point, 16s delay	0.7	0.7	0.7	0.8	-0.8
Delay disc. indifference point, 2s delay	1.7	1.9	1.9	-1.4	1.4
Delay disc. indifference point, 24s delay	1.1	1.1	1.1	1.0	-1.0
Delay disc. indifference point, 4s delay	1.6	1.7	1.7	-1.3	1.3
Delay disc. indifference point, 8s delay	0.2	0.2	0.2	0.4	-0.4
Delay discount exponential model param	0.0	0.0	0.0	0.2	-0.2
Delay discount hyperbolic model param	0.2	0.2	0.2	0.4	-0.4
Fecal boli incidents, locomotor time 1	0.8	0.8	0.8	0.9	-0.9
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	0.1	-0.1
Time >=10cm from walls, locomotor time 1	0.7	0.7	0.7	0.8	-0.8
Bouts of movement, locomotor time 1	1.7	1.9	1.9	1.4	-1.4
Total resting periods, locomotor time 1	2.5	2.8	2.8	1.7	-1.7
Rest time, locomotor task time 1	0.4	0.5	0.5	0.7	-0.7
Distance moved, locomotor task time 1	0.1	0.1	0.1	0.3	-0.3
Vertical activity count, locomotor time 1	0.4	0.5	0.5	-0.7	0.7
Time >=10cm from walls, locomotor time 2	1.1	1.2	1.2	-1.1	1.1
Bouts of movement, locomotor time 2	0.6	0.6	0.6	-0.8	0.8
Total resting periods, locomotor time 2	0.5	0.5	0.5	-0.7	0.7
Rest time, locomotor task time 2	0.0	0.0	0.0	0.1	-0.1
Distance moved, locomotor task time 2	0.5	0.6	0.6	0.8	-0.8
Vertical activity count, locomotor time 2	0.0	0.0	0.0	-0.1	0.1
Weight adjusted by age	0.2	0.2	0.2	-0.5	0.5
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.3	-0.6	0.6
Locomotion in novel chamber	0.9	1.1	1.1	1.1	-1.1
Locomotion in novel chamber post-restriction	1.4	1.7	1.7	1.3	-1.3
Progressive ratio	1.9	2.2	2.2	1.5	-1.5
Food seeking constrained by brief footshock	2.5	3.1	3.1	1.8	-1.8
Seeking ratio, punishment vs. effort	0.6	0.8	0.8	-0.9	0.9
Run reversals in cocaine runway, females	2.4	2.4	2.4	-1.5	1.5
Run reversals in cocaine runway, males	1.6	1.5	1.5	-1.2	1.2
Latency to leave start box in cocaine runway	0.0	0.0	0.0	-0.1	0.1
Latency to leave start box in cocaine runway, F	0.2	0.2	0.2	-0.4	0.4
Latency to leave start box in cocaine runway, M	0.6	0.6	0.6	0.8	-0.8
Cd content in liver	1.1	1.2	1.2	-1.1	1.1
Co content in liver	0.4	0.5	0.5	0.7	-0.7
Cu content in liver	0.5	0.6	0.6	0.7	-0.7
Fe content in liver	0.4	0.4	0.4	-0.6	0.6
K content in liver	0.1	0.1	0.1	0.3	-0.3
Mg content in liver	0.1	0.1	0.1	-0.3	0.3
Mn content in liver	2.0	2.3	2.3	1.5	-1.5
Na content in liver	0.2	0.3	0.3	-0.5	0.5
Rb content in liver	1.0	1.2	1.2	-1.1	1.1
Se content in liver	0.2	0.3	0.3	-0.5	0.5
Sr content in liver	0.5	0.4	0.4	0.7	-0.7
Zn content in liver	0.1	0.1	0.1	0.3	-0.3