Best TWAS P = 7.60e-10 · Best GWAS P= 3.86e-10 conditioned to 1.00e+00
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | LOC108352541 | mRNA stability | LOC108352541 | 0.13 | 36 | 0.07 | 5.9e-08 | -5.32 | 1.05e-07 | 0.62 | FALSE |
| BLA | Nek7 | gene expression | Nek7 | 0.23 | 2450 | 0.17 | 2.4e-09 | -5.23 | 1.73e-07 | 0.38 | FALSE |
| Brain | Crb1 | gene expression | Crb1 | 0.72 | 16 | 0.38 | 2.4e-37 | 5.57 | 2.59e-08 | 0.8 | FALSE |
| Brain | LOC108352541 | gene expression | LOC108352541 | 0.14 | 1 | 0.1 | 6.2e-10 | 5.58 | 2.42e-08 | 0.09 | FALSE |
| Brain | Nek7 | isoform ratio | NM_001108346.3 | 0.05 | 2450 | 0.04 | 1.0e-04 | -5.25 | 1.55e-07 | 0.51 | FALSE |
| IL | LOC108352541 | gene expression | LOC108352541 | 0.25 | 2884 | 0.08 | 6.3e-03 | 5.93 | 2.99e-09 | 0.33 | FALSE |
| IL | LOC134481501 | gene expression | LOC134481501 | 0.52 | 2476 | 0.27 | 3.2e-07 | -5.21 | 1.90e-07 | 0.62 | FALSE |
| LHb | Nek7 | isoform ratio | NM_001108346.3 | 0.19 | 1 | 0.07 | 9.4e-03 | -5.57 | 2.61e-08 | 0.05 | FALSE |
| Liver | Cfhr2 | alternative TSS | NM_001420253.1 | 0.06 | 1 | 0.01 | 6.7e-03 | 5.38 | 7.64e-08 | 0.03 | FALSE |
| NAcc | LOC108352541 | gene expression | LOC108352541 | 0.03 | 2884 | 0.02 | 1.5e-04 | 6.07 | 1.27e-09 | 0.59 | FALSE |
| PL | LOC108352541 | gene expression | LOC108352541 | 0.15 | 1 | 0.11 | 4.7e-12 | 6.15 | 7.60e-10 | 0.73 | TRUE |
| PL | Nek7 | gene expression | Nek7 | 0.06 | 2450 | 0.04 | 2.2e-05 | -5.29 | 1.22e-07 | 0.48 | FALSE |
| pVTA | LOC108352541 | gene expression | LOC108352541 | 0.14 | 1 | 0.13 | 1.8e-10 | 5.88 | 3.99e-09 | 0.35 | FALSE |
| RMTg | LOC134481501 | gene expression | LOC134481501 | 0.29 | 1 | 0.2 | 6.9e-06 | -5.38 | 7.45e-08 | 0.06 | FALSE |