Best TWAS P=2.5636e-08 · Best GWAS P=4.320111e-08 conditioned to 0
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Brain | Clic2 | gene expression | ENSRNOG00000000728 | 0.22 | 0.18 | lasso | 47 | 0.20 | 2.6e-18 | -5.1 | -5.3 | 1.4e-07 | 0.61 | 0.58 | 0.42 | TRUE |
| 2 | IL | Tmlhe | mRNA stability | ENSRNOG00000000729 | 0.23 | -0.01 | blup | 2288 | 0.04 | 3.7e-02 | 2.7 | -5.6 | 2.6e-08 | 0.85 | 0.37 | 0.27 | TRUE |
| 3 | Liver | Clic2 | gene expression | ENSRNOG00000000728 | 0.25 | 0.23 | top1 | 1 | 0.23 | 2.9e-25 | -5.2 | -5.2 | 2.5e-07 | 0.74 | 0.54 | 0.46 | FALSE |
| 4 | PL2 | Tmlhe | intron excision ratio | chr20:108174:117685 | 0.74 | 0.62 | lasso | 28 | 0.62 | 3.8e-42 | 2.5 | -5.5 | 3.2e-08 | -0.18 | 1.00 | 0.00 | TRUE |
| 5 | PL2 | NA | intron excision ratio | chr20:24798:30877 | 0.14 | 0.07 | lasso | 11 | 0.07 | 7.3e-05 | -3.6 | 5.1 | 2.7e-07 | 0.16 | 0.97 | 0.03 | FALSE |
| 6 | PL2 | NA | intron excision ratio | chr20:33392:35421 | 0.16 | 0.07 | lasso | 9 | 0.08 | 5.9e-05 | -3.6 | -5.3 | 1.0e-07 | -0.17 | 0.97 | 0.02 | TRUE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.