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chr10:92,588,108-96,071,622

Trait: Body weight

Best TWAS P=1.761219e-10 · Best GWAS P=1.508531e-10 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Wipi1	alternative polyA	ENSRNOT00000005257	0.04	0.00	blup	2914	0.01	2.0e-02	5.6	-5.4	8.5e-08	0.81	0.46	0.25	FALSE
2	Adipose	Prkar1a	alternative TSS	ENSRNOT00000119272	0.03	0.01	top1	1	0.01	1.2e-02	5.7	5.7	1.5e-08	-0.80	0.09	0.04	FALSE
3	Adipose	Abca6	gene expression	ENSRNOG00000046890	0.26	0.25	enet	136	0.33	3.2e-37	5.9	-6.1	8.5e-10	0.64	0.14	0.86	FALSE
4	Adipose	Prkar1a	gene expression	ENSRNOG00000049876	0.08	0.07	blup	2933	0.07	3.0e-08	4.8	5.5	4.4e-08	-0.84	0.34	0.66	FALSE
5	Adipose	Abca9	gene expression	ENSRNOG00000059326	0.65	0.54	enet	98	0.57	3.0e-77	5.9	-5.8	5.3e-09	0.63	0.16	0.84	FALSE
6	Adipose	Arsg	intron excision ratio	chr10:94518127:94528234	0.10	0.07	top1	1	0.07	7.9e-08	5.7	-5.7	1.5e-08	0.89	0.64	0.34	FALSE
7	Adipose	Abca8a	intron excision ratio	chr10:95084476:95085220	0.09	0.08	enet	86	0.08	2.2e-09	6.1	-5.7	1.3e-08	0.66	0.31	0.69	FALSE
8	Adipose	Cep112	intron excision ratio	chr10:93731914:93738578	0.06	0.04	top1	1	0.04	4.2e-05	-5.6	5.6	2.4e-08	-0.94	0.23	0.06	FALSE
9	Adipose	Abca9	intron excision ratio	chr10:95084476:95085220	0.09	0.08	top1	1	0.08	3.1e-09	6.1	-6.1	8.9e-10	0.76	0.06	0.94	FALSE
10	Adipose	Prkar1a	mRNA stability	ENSRNOG00000049876	0.03	0.01	top1	1	0.01	8.1e-03	5.6	5.6	2.1e-08	-0.89	0.14	0.07	FALSE
11	Adipose	Abca9	mRNA stability	ENSRNOG00000059326	0.32	0.24	enet	105	0.28	1.0e-31	5.9	5.5	3.9e-08	-0.72	0.15	0.85	FALSE
12	BLA	Amz2	gene expression	ENSRNOG00000000246	0.29	0.30	blup	2776	0.32	5.5e-18	5.8	5.3	8.9e-08	-0.83	0.48	0.52	TRUE
13	BLA	Abca6	gene expression	ENSRNOG00000046890	0.15	0.12	top1	1	0.12	7.7e-07	5.7	-5.7	1.2e-08	0.72	0.43	0.56	FALSE
14	BLA	Axin2	gene expression	ENSRNOG00000055010	0.07	0.08	top1	1	0.08	4.9e-05	-6.1	-6.1	1.1e-09	0.96	0.11	0.15	FALSE
15	BLA	Abca9	gene expression	ENSRNOG00000059326	0.73	0.57	top1	1	0.57	9.0e-37	5.1	-5.1	3.2e-07	0.76	0.95	0.05	FALSE
16	BLA	Arsg	intron excision ratio	chr10:94460446:94461943	0.21	0.28	top1	1	0.28	2.2e-15	5.9	5.9	2.7e-09	-0.89	0.27	0.73	FALSE
17	Brain	Slc16a6	alternative TSS	ENSRNOT00000078059	0.04	0.03	blup	2839	0.04	3.2e-04	5.8	5.7	1.4e-08	-0.88	0.48	0.52	FALSE
18	Brain	Slc16a6	alternative TSS	ENSRNOT00000088215	0.13	0.08	blup	2839	0.09	2.0e-08	5.8	-5.6	2.1e-08	0.89	0.40	0.60	FALSE
19	Brain	Slc16a6	gene expression	ENSRNOG00000000245	0.35	0.35	enet	176	0.36	2.8e-35	5.8	5.7	1.1e-08	-0.83	0.52	0.48	FALSE
20	Brain	Amz2	gene expression	ENSRNOG00000000246	0.33	0.28	blup	2776	0.28	3.6e-26	5.8	5.7	1.3e-08	-0.83	0.53	0.47	FALSE
21	Brain	Prkca	gene expression	ENSRNOG00000003491	0.12	0.08	top1	1	0.08	4.3e-08	-5.9	-5.9	4.5e-09	0.95	0.43	0.56	FALSE
22	Brain	Rgs9	gene expression	ENSRNOG00000003800	0.06	0.05	top1	1	0.05	2.4e-05	-6.1	-6.1	1.4e-09	0.89	0.18	0.55	FALSE
23	Brain	Cep112	gene expression	ENSRNOG00000024557	0.11	0.09	enet	4	0.10	1.3e-09	-5.9	-6.3	3.3e-10	-0.60	0.33	0.67	TRUE
24	Brain	AABR07030647.1	gene expression	ENSRNOG00000033613	0.07	0.09	top1	1	0.09	2.0e-08	-6.0	6.0	2.2e-09	-0.94	0.38	0.62	FALSE
25	Brain	Abca6	gene expression	ENSRNOG00000046890	0.18	0.22	lasso	22	0.22	2.4e-20	5.1	-5.4	6.7e-08	0.71	0.16	0.84	FALSE
26	Brain	Axin2	gene expression	ENSRNOG00000055010	0.31	0.25	enet	55	0.29	2.8e-27	4.9	-5.2	1.9e-07	0.72	0.76	0.24	FALSE
27	Brain	Abca9	gene expression	ENSRNOG00000059326	0.59	0.62	lasso	27	0.64	1.9e-77	5.1	-5.4	5.7e-08	0.70	0.17	0.83	FALSE
28	Brain	NA	gene expression	ENSRNOG00000065020	0.09	0.08	top1	1	0.08	8.7e-08	6.0	6.0	2.3e-09	-0.67	0.13	0.86	FALSE
29	Brain	Slc16a6	isoform ratio	ENSRNOT00000088215	0.12	0.07	blup	2839	0.08	9.6e-08	5.8	-5.7	1.4e-08	0.89	0.40	0.60	FALSE
30	Brain	Arsg	intron excision ratio	chr10:94460446:94461943	0.34	0.42	lasso	45	0.42	1.4e-42	5.8	5.8	8.1e-09	-0.86	0.52	0.48	FALSE
31	Brain	Map2k6	intron excision ratio	chr10:95373426:95448972	0.19	0.10	blup	2814	0.17	6.1e-16	5.9	6.3	2.5e-10	-0.59	0.40	0.60	FALSE
32	Brain	Map2k6	intron excision ratio	chr10:95447514:95448972	0.15	0.09	blup	2814	0.16	2.9e-14	-4.7	-6.4	1.8e-10	0.60	0.30	0.70	TRUE
33	Brain	Rgs9	mRNA stability	ENSRNOG00000003800	0.07	0.06	blup	2492	0.06	2.4e-06	6.0	-6.2	6.4e-10	0.91	0.46	0.54	FALSE
34	Eye	Wipi1	alternative TSS	ENSRNOT00000005257	0.39	0.03	blup	2914	0.06	5.1e-02	4.8	5.7	1.2e-08	-0.81	0.34	0.17	FALSE
35	Eye	Wipi1	alternative TSS	ENSRNOT00000005257	0.45	0.04	blup	2914	0.08	2.1e-02	4.8	5.5	3.6e-08	-0.76	0.36	0.16	FALSE
36	Eye	Wipi1	alternative TSS	ENSRNOT00000109014	0.51	0.03	blup	2914	0.09	1.7e-02	4.8	-5.5	2.9e-08	0.76	0.38	0.19	TRUE
37	IL	Amz2	gene expression	ENSRNOG00000000246	0.32	0.15	blup	2767	0.17	6.0e-05	5.8	6.0	2.5e-09	-0.91	0.35	0.63	FALSE
38	IL	Rgs9	gene expression	ENSRNOG00000003800	0.25	-0.01	blup	2485	0.04	3.2e-02	-3.9	-5.4	6.3e-08	0.74	0.46	0.16	FALSE
39	IL	Axin2	gene expression	ENSRNOG00000055010	0.32	0.17	blup	2027	0.23	3.1e-06	-5.5	-5.3	1.1e-07	0.89	0.46	0.52	FALSE
40	IL	Abca9	gene expression	ENSRNOG00000059326	0.47	0.32	top1	1	0.32	1.4e-08	5.6	-5.6	1.7e-08	0.74	0.39	0.34	FALSE
41	LHb	Slc16a6	gene expression	ENSRNOG00000000245	0.20	0.20	top1	1	0.20	1.4e-05	5.8	5.8	8.6e-09	-0.90	0.17	0.08	FALSE
42	LHb	Amz2	gene expression	ENSRNOG00000000246	0.17	0.09	blup	2765	0.14	3.5e-04	5.8	5.6	2.1e-08	-0.86	0.46	0.40	FALSE
43	LHb	Arsg	gene expression	ENSRNOG00000003931	0.39	0.21	lasso	2	0.24	2.7e-06	-4.0	6.0	1.9e-09	-0.06	0.95	0.03	TRUE
44	LHb	Cep112	gene expression	ENSRNOG00000024557	0.35	0.25	top1	1	0.25	1.5e-06	-5.5	-5.5	2.9e-08	0.96	0.16	0.06	FALSE
45	LHb	Abca9	gene expression	ENSRNOG00000059326	0.41	0.30	blup	3135	0.32	2.2e-08	5.4	-5.7	1.0e-08	0.76	0.33	0.67	TRUE
46	Liver	Slc16a6	gene expression	ENSRNOG00000000245	0.08	0.07	lasso	13	0.08	7.5e-09	5.9	-5.9	3.9e-09	0.85	0.50	0.50	FALSE
47	Liver	Apoh	gene expression	ENSRNOG00000003566	0.27	0.15	blup	2190	0.21	4.1e-23	-5.6	5.8	7.2e-09	-0.79	0.41	0.59	FALSE
48	Liver	Cep112	isoform ratio	ENSRNOT00000037067	0.03	0.02	top1	1	0.02	2.3e-03	-5.4	5.4	8.1e-08	-0.99	0.07	0.03	FALSE
49	Liver	Abca6	intron excision ratio	chr10:95209800:95211144	0.07	0.08	top1	1	0.08	1.5e-09	5.7	-5.7	1.1e-08	0.74	0.41	0.58	FALSE
50	Liver	Abca6	intron excision ratio	chr10:95209800:95211153	0.07	0.05	top1	1	0.05	5.8e-06	6.1	-6.1	9.4e-10	0.70	0.06	0.94	FALSE
51	Liver	Abca6	intron excision ratio	chr10:95209800:95211289	0.21	0.22	enet	127	0.24	4.5e-26	5.7	5.8	5.9e-09	-0.61	0.17	0.83	FALSE
52	Liver	Apoh	mRNA stability	ENSRNOG00000003566	0.27	0.26	enet	72	0.27	2.3e-29	-5.6	5.6	1.9e-08	-0.99	0.32	0.68	FALSE
53	Liver	Arsg	mRNA stability	ENSRNOG00000003931	0.07	0.05	blup	2846	0.06	1.7e-07	5.7	-5.7	1.3e-08	0.88	0.50	0.50	FALSE
54	NAcc	Cep112	alternative TSS	ENSRNOT00000108519	0.13	0.11	top1	1	0.11	1.2e-08	-5.6	-5.6	2.5e-08	0.93	0.84	0.15	FALSE
55	NAcc	Slc16a6	gene expression	ENSRNOG00000000245	0.04	0.01	blup	2838	0.03	1.3e-03	4.8	5.9	4.6e-09	-0.88	0.36	0.59	FALSE
56	NAcc	Amz2	gene expression	ENSRNOG00000000246	0.14	0.19	top1	1	0.19	5.9e-14	5.9	5.9	4.1e-09	-0.89	0.35	0.65	FALSE
57	NAcc	Rgs9	gene expression	ENSRNOG00000003800	0.07	0.06	top1	1	0.06	4.7e-05	5.8	-5.8	6.3e-09	0.91	0.24	0.17	FALSE
58	NAcc	Cep112	gene expression	ENSRNOG00000024557	0.06	0.07	top1	1	0.07	1.1e-05	-5.4	-5.4	6.2e-08	0.91	0.26	0.04	FALSE
59	NAcc	Abca6	gene expression	ENSRNOG00000046890	0.15	0.12	lasso	21	0.12	1.6e-09	5.8	-5.1	3.4e-07	0.69	0.19	0.81	FALSE
60	NAcc	Abca9	gene expression	ENSRNOG00000059326	0.55	0.54	lasso	21	0.59	1.9e-54	5.8	-5.6	1.9e-08	0.70	0.21	0.79	FALSE
61	NAcc	Arsg	intron excision ratio	chr10:94460446:94461943	0.16	0.17	top1	1	0.17	2.3e-12	5.9	5.9	3.7e-09	-0.86	0.33	0.67	FALSE
62	NAcc	Wipi1	mRNA stability	ENSRNOG00000003827	0.06	0.02	top1	1	0.02	6.2e-03	-6.0	6.0	1.5e-09	-0.83	0.10	0.05	FALSE
63	NAcc	Abca9	mRNA stability	ENSRNOG00000059326	0.06	0.01	blup	3119	0.03	4.8e-03	6.3	-5.4	6.5e-08	0.62	0.35	0.60	FALSE
64	OFC	Amz2	gene expression	ENSRNOG00000000246	0.27	0.07	blup	2767	0.13	6.7e-04	-6.0	6.0	1.5e-09	-0.91	0.35	0.64	FALSE
65	OFC	Abca6	gene expression	ENSRNOG00000046890	0.15	0.04	enet	7	0.07	8.0e-03	6.0	-5.3	1.1e-07	0.63	0.35	0.45	FALSE
66	OFC	Abca9	gene expression	ENSRNOG00000059326	0.61	0.43	blup	3136	0.48	3.8e-13	5.1	-6.1	8.5e-10	0.69	0.25	0.75	FALSE
67	OFC	Prkca	mRNA stability	ENSRNOG00000003491	0.19	0.02	lasso	4	0.08	5.0e-03	-4.3	5.1	2.9e-07	-0.60	0.38	0.12	TRUE
68	PL	Rgs9	alternative polyA	ENSRNOT00000096063	0.04	0.02	top1	1	0.02	9.1e-03	5.9	-5.9	3.2e-09	0.90	0.09	0.04	FALSE
69	PL	Amz2	gene expression	ENSRNOG00000000246	0.25	0.20	enet	153	0.22	5.9e-17	5.9	5.4	6.5e-08	-0.84	0.53	0.47	FALSE
70	PL	Cep112	gene expression	ENSRNOG00000024557	0.14	0.10	top1	1	0.10	2.4e-08	-5.4	-5.4	6.2e-08	0.99	0.93	0.07	TRUE
71	PL	Abca6	gene expression	ENSRNOG00000046890	0.20	0.18	top1	1	0.18	2.6e-13	5.9	-5.9	3.4e-09	0.72	0.18	0.82	FALSE
72	PL	Abca9	gene expression	ENSRNOG00000059326	0.56	0.52	lasso	47	0.54	3.2e-48	6.0	-6.2	7.5e-10	0.68	0.14	0.86	FALSE
73	PL	Rgs9	isoform ratio	ENSRNOT00000005076	0.06	0.03	top1	1	0.03	1.4e-03	-6.1	6.1	1.3e-09	-0.90	0.11	0.19	FALSE
74	PL	Rgs9	isoform ratio	ENSRNOT00000096063	0.04	0.02	top1	1	0.02	6.4e-03	5.9	-5.9	3.2e-09	0.90	0.09	0.05	FALSE
75	PL	Wipi1	isoform ratio	ENSRNOT00000005172	0.04	0.01	blup	2910	0.02	1.1e-02	5.9	5.6	2.4e-08	-0.76	0.44	0.32	FALSE
76	PL	Wipi1	isoform ratio	ENSRNOT00000005257	0.04	0.03	top1	1	0.03	2.5e-03	5.8	-5.8	8.2e-09	0.84	0.10	0.05	FALSE
77	PL	Map2k6	intron excision ratio	chr10:95373426:95448972	0.18	0.21	lasso	20	0.24	1.6e-18	5.6	5.7	1.1e-08	-0.65	0.24	0.76	FALSE
78	PL	Map2k6	intron excision ratio	chr10:95447514:95448972	0.23	0.28	lasso	17	0.30	1.0e-22	5.6	-5.6	2.1e-08	0.65	0.33	0.67	FALSE
79	PL	Wipi1	mRNA stability	ENSRNOG00000003827	0.05	0.05	top1	1	0.06	5.3e-05	5.9	5.9	3.0e-09	-0.86	0.14	0.34	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.