Best TWAS P=1.817302e-08 · Best GWAS P=1.431883e-07 conditioned to 0.3274874
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | Igf1r | mRNA stability | ENSRNOG00000014187 | 0.05 | 0.05 | top1 | 1 | 0.04 | 8.1e-06 | 5.1 | -5.1 | 3.0e-07 | -0.90 | 0.18 | 0.69 | FALSE |
| 2 | IL | Synm | isoform ratio | ENSRNOT00000050832 | 0.45 | 0.11 | enet | 8 | 0.15 | 2.4e-04 | -0.3 | 5.2 | 2.5e-07 | 0.71 | 0.51 | 0.03 | FALSE |
| 3 | LHb | Fam169b | gene expression | ENSRNOG00000022822 | 0.32 | 0.22 | enet | 6 | 0.30 | 5.7e-08 | -3.9 | -5.6 | 1.8e-08 | -0.84 | 0.46 | 0.52 | TRUE |
| 4 | PL2 | Fam169b | intron excision ratio | chr1:121879504:121899372 | 0.05 | 0.02 | blup | 2093 | 0.03 | 7.1e-03 | -4.7 | 5.2 | 1.7e-07 | 0.88 | 0.43 | 0.36 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.