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chr8:95,494,368-98,183,778

Trait: Body weight

Best TWAS P=5.508083e-10 · Best GWAS P=1.697541e-08 conditioned to 1.588753e-119

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Tfdp2	gene expression	ENSRNOG00000011241	0.52	0.47	enet	158	0.48	1.1e-60	-5.4	5.3	1.1e-07	-0.98	0.24	0.76	FALSE
2	Adipose	Trpc1	gene expression	ENSRNOG00000054902	0.06	0.03	blup	2008	0.03	1.4e-04	-5.5	5.6	2.3e-08	-0.79	0.22	0.76	FALSE
3	Adipose	Trpc1	intron excision ratio	chr8:96280099:96282351	0.04	0.02	blup	2008	0.02	1.1e-03	-5.5	5.3	1.5e-07	-0.94	0.26	0.73	FALSE
4	BLA	Tfdp2	gene expression	ENSRNOG00000011241	0.08	0.08	lasso	5	0.08	5.4e-05	-5.4	5.4	7.1e-08	-0.99	0.36	0.62	FALSE
5	BLA	Tfdp2	isoform ratio	ENSRNOT00000081204	0.08	0.05	top1	1	0.05	8.7e-04	-5.5	-5.5	3.5e-08	0.98	0.10	0.22	FALSE
6	BLA	Trpc1	intron excision ratio	chr8:96280099:96282351	0.06	0.03	blup	2010	0.05	1.2e-03	-5.4	5.5	2.9e-08	-0.96	0.27	0.68	FALSE
7	Brain	Tfdp2	gene expression	ENSRNOG00000011241	0.13	0.12	blup	1807	0.15	1.6e-13	-4.1	5.1	3.5e-07	-0.94	0.48	0.52	FALSE
8	Brain	Atp1b3	gene expression	ENSRNOG00000011501	0.08	0.03	lasso	9	0.05	1.2e-05	5.1	6.2	5.5e-10	-0.75	0.34	0.66	TRUE
9	Brain	Tfdp2	isoform ratio	ENSRNOT00000081204	0.04	0.03	top1	1	0.03	7.3e-04	-5.3	-5.3	1.5e-07	0.97	0.09	0.07	FALSE
10	Brain	Tfdp2	intron excision ratio	chr8:96795874:96804811	0.07	0.04	top1	1	0.04	7.3e-05	5.2	-5.2	2.1e-07	0.53	0.13	0.08	FALSE
11	Brain	Atp1b3	intron excision ratio	chr8:96922523:96941339	0.05	0.05	top1	1	0.05	3.3e-05	-5.3	-5.3	1.2e-07	0.96	0.30	0.38	FALSE
12	Brain	Trpc1	intron excision ratio	chr8:96280099:96280911	0.13	0.07	top1	1	0.07	2.1e-07	-5.5	-5.5	3.6e-08	0.97	0.16	0.81	FALSE
13	Brain	Trpc1	intron excision ratio	chr8:96280099:96282351	0.15	0.14	enet	148	0.15	1.2e-13	-5.5	5.9	4.1e-09	-0.95	0.23	0.77	FALSE
14	Brain	Trpc1	intron excision ratio	chr8:96280967:96282351	0.11	0.06	top1	1	0.06	7.2e-06	-5.3	-5.3	1.5e-07	0.96	0.43	0.54	FALSE
15	Brain	Pls1	mRNA stability	ENSRNOG00000009945	0.18	0.15	top1	1	0.15	7.8e-14	-5.5	-5.5	3.5e-08	0.96	0.18	0.82	FALSE
16	Brain	Gk5	mRNA stability	ENSRNOG00000010942	0.10	0.06	blup	1867	0.08	1.0e-07	-5.0	5.5	4.8e-08	-0.89	0.39	0.61	FALSE
17	Brain	Atp1b3	mRNA stability	ENSRNOG00000011501	0.37	0.33	lasso	25	0.34	4.5e-32	-5.1	5.3	1.2e-07	-0.97	0.36	0.64	FALSE
18	Brain	Trpc1	mRNA stability	ENSRNOG00000054902	0.13	0.09	lasso	29	0.10	7.3e-10	-5.6	5.3	1.2e-07	-0.86	0.30	0.70	FALSE
19	Eye	Tfdp2	alternative TSS	ENSRNOT00000107228	0.54	0.07	lasso	37	0.09	1.9e-02	-4.9	5.5	3.3e-08	-0.90	0.32	0.38	FALSE
20	IL	Atp1b3	mRNA stability	ENSRNOG00000011501	0.22	0.03	enet	13	0.06	1.7e-02	-5.6	5.2	2.4e-07	-0.94	0.28	0.42	FALSE
21	LHb	PCOLCE2	gene expression	ENSRNOG00000046848	0.44	0.22	top1	1	0.22	5.3e-06	-5.2	5.2	2.3e-07	-0.90	0.13	0.17	FALSE
22	Liver	Zbtb38	alternative polyA	ENSRNOT00000097273	0.03	0.02	top1	1	0.02	1.7e-03	-5.3	5.3	1.1e-07	-0.40	0.05	0.22	TRUE
23	Liver	PCOLCE2	gene expression	ENSRNOG00000046848	0.10	0.08	top1	1	0.09	1.2e-09	-5.4	5.4	6.5e-08	-0.93	0.10	0.90	FALSE
24	Liver	Trpc1	gene expression	ENSRNOG00000054902	0.10	0.08	enet	92	0.08	2.2e-09	-4.9	5.3	1.3e-07	-0.97	0.24	0.76	FALSE
25	Liver	Pls1	mRNA stability	ENSRNOG00000009945	0.02	0.02	blup	1970	0.02	4.4e-03	-5.2	-5.6	2.2e-08	0.85	0.24	0.45	FALSE
26	Liver	Atp1b3	mRNA stability	ENSRNOG00000011501	0.07	0.08	top1	1	0.08	6.5e-09	-5.2	5.2	2.0e-07	-0.98	0.55	0.44	FALSE
27	NAcc	Trpc1	intron excision ratio	chr8:96280099:96282351	0.09	0.07	top1	1	0.07	6.2e-06	-5.3	5.3	1.5e-07	-0.97	0.26	0.30	FALSE
28	NAcc	Pls1	mRNA stability	ENSRNOG00000009945	0.07	0.05	enet	59	0.05	1.2e-04	-5.5	-5.4	8.2e-08	0.97	0.32	0.68	FALSE
29	PL	Gk5	gene expression	ENSRNOG00000010942	0.39	0.13	blup	1862	0.15	8.6e-12	-5.5	5.5	4.3e-08	-0.94	0.33	0.67	FALSE
30	PL	Rnf7	gene expression	ENSRNOG00000011663	0.07	0.03	lasso	3	0.06	2.2e-05	4.3	5.4	7.6e-08	-0.49	0.75	0.12	FALSE
31	PL	Atp1b3	mRNA stability	ENSRNOG00000011501	0.10	0.11	blup	1718	0.11	7.0e-09	-5.3	5.8	8.5e-09	-0.93	0.28	0.72	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.