Hub : Genes

Plxnc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000007970	0.05	0.03	5.6e-05	0.03	0.03	0.03	0.04	1.3e-04	5.7e-04	1.1e-04	6.8e-05
2	Adipose	mRNA stability	ENSRNOG00000007970	0.04	0.02	1.1e-03	0.01	0	0.01	0	5.1e-02	7.6e-02	7.1e-02	2.7e-01
3	BLA	gene expression	ENSRNOG00000007970	0.17	0.08	1.7e-07	0.06	0.11	0.1	0.1	2.5e-04	2.6e-06	3.8e-06	3.0e-06
4	BLA	mRNA stability	ENSRNOG00000007970	0.11	0.07	3.5e-04	0.1	0.06	0.05	0.09	3.0e-06	6.7e-04	1.0e-03	1.4e-05
5	Brain	gene expression	ENSRNOG00000007970	0.05	0.03	1.7e-04	0.02	0.04	0.03	0.03	8.3e-03	6.3e-05	1.9e-03	8.1e-04
6	LHb	gene expression	ENSRNOG00000007970	0.41	0.13	3.1e-06	0.09	0.22	0.17	0.18	3.5e-03	7.2e-06	6.4e-05	4.3e-05
7	NAcc	gene expression	ENSRNOG00000007970	0.12	0.06	5.6e-09	0.13	0.12	0.12	0.13	1.1e-09	1.9e-09	1.7e-09	1.0e-09
8	PL	gene expression	ENSRNOG00000007970	0.1	0.06	1.6e-03	0.06	0.03	0.04	0.05	1.9e-05	2.1e-03	5.8e-04	6.0e-05
9	PL	mRNA stability	ENSRNOG00000007970	0.05	0.03	8.7e-04	0.05	0.04	0.03	0.04	1.2e-04	4.1e-04	1.9e-03	3.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
BMI with tail	1.1	3.4	13.3	3.6	-0.2	-0.3	1.2	-1.2	-0.7	-2.4	-0.0	2.9
BMI without tail	3.0	6.3	13.1	2.7	-1.5	-2.0	2.5	-2.2	-2.6	-3.5	0.1	3.6
Body weight	9.2	38.9	83.7	4.5	-3.8	-5.0	7.8	-5.6	-6.8	-8.2	-0.3	9.1
Epididymis fat weight	1.4	3.2	6.8	2.5	-1.1	-0.7	2.4	-1.3	-0.8	-2.4	-0.5	2.6
Glucose	0.1	0.2	1.1	-0.5	-0.3	-0.3	-0.2	-0.4	-0.0	-0.2	-1.0	-0.4
Heart weight	0.6	0.8	3.4	0.9	1.8	1.0	0.9	0.7	0.4	0.6	-0.3	0.5
Left kidney weight	2.1	6.1	10.2	0.3	-1.6	-2.6	3.2	-2.8	-2.9	-2.9	-1.0	3.1
Right kidney weight	1.2	3.5	6.9	1.0	-0.8	-1.7	2.5	-1.7	-2.2	-2.5	-0.2	2.6
Tail length	8.4	25.3	45.2	1.1	-4.1	-5.1	6.7	-4.6	-6.5	-6.2	-0.2	6.0
Length with tail	11.8	43.1	84.0	1.6	-5.1	-6.3	9.2	-6.1	-8.0	-7.9	-0.3	8.6
Length without tail	5.7	12.4	27.9	0.5	-2.5	-3.0	5.3	-3.3	-4.0	-3.8	-0.5	5.1
Liver weight, left	0.0	0.1	0.2	0.3	-0.2	0.1	0.2	-0.2	0.2	-0.5	-0.0	0.2
Liver weight, right	0.3	0.6	1.9	0.3	-0.8	-0.4	1.4	-0.7	-0.5	-0.7	-0.5	0.9
Parametrial fat weight	1.1	2.2	3.9	1.1	1.8	2.0	-1.3	1.6	1.8	1.2	0.2	-1.6
Retroperitoneal fat weight	1.0	3.2	6.6	1.7	-1.1	-1.0	2.6	-1.6	-1.4	-2.5	-0.8	2.4
Intraocular pressure	0.2	0.3	0.7	-0.3	-0.3	0.8	-0.3	0.8	0.8	0.6	0.1	-0.4
Extensor digitorum longus weight	0.1	0.6	1.3	1.0	1.1	-0.4	0.2	-0.2	-1.0	-0.7	0.6	0.7
Soleus weight	0.1	0.4	1.5	1.2	0.9	0.6	0.4	0.4	-0.0	-0.3	0.2	0.7
Tibialis anterior weight	0.4	1.3	4.4	2.1	2.1	1.1	-0.2	1.0	0.4	0.4	0.4	0.0
Tibia length	6.3	17.8	32.8	2.1	-3.1	-3.9	5.2	-4.2	-4.8	-5.7	-0.0	5.4
Number of licking bursts	0.4	0.4	1.5	1.2	-0.2	-0.1	-0.0	-0.4	-0.0	-0.7	-1.2	0.5
Food consumed during 24 hour testing period	0.6	0.7	1.5	-0.8	-1.2	-1.0	-0.4	-0.8	-0.6	-1.0	0.6	0.9
Times rat made contact with spout	4.2	4.8	7.3	-0.5	-2.7	-2.4	1.2	-2.7	-2.3	-2.5	-2.4	2.0
Mean time between licks in bursts	0.1	0.2	0.6	0.8	0.5	-0.3	0.2	-0.6	-0.3	-0.3	-0.4	0.4
Mean num. licks in bursts	0.5	0.6	1.9	-1.4	-0.9	-0.9	0.2	-0.9	-0.8	-0.4	-0.3	0.3
Std. dev. time between licks in bursts	1.0	1.2	3.4	1.0	1.8	1.2	-0.2	0.8	1.3	1.2	-0.1	-0.8
Water consumed over 24 hours	1.1	1.3	2.6	0.1	-1.2	-1.4	0.2	-1.2	-1.4	-1.6	-0.2	1.5
Indifference point 0 sec	0.3	0.4	1.4	-0.1	-0.1	-0.1	1.2	-0.1	-0.7	-0.1	-0.7	1.2
Indifference point AUC	0.7	0.8	1.3	-1.0	-0.9	-0.9	1.0	-0.8	-1.1	-0.6	-0.9	0.6
Indifference point function ln k	0.4	0.6	1.6	1.1	0.5	0.6	-0.7	0.6	0.7	0.1	1.3	-0.3
Indifference point function log k	0.4	0.6	1.6	1.1	0.5	0.6	-0.7	0.6	0.7	0.1	1.3	-0.3
Delay discounting total patch changes 0 sec	0.2	0.4	1.3	0.1	0.1	-0.1	1.1	-0.2	-0.6	-0.1	-0.8	1.1
Delay discounting total patch changes 12 sec	2.2	2.9	7.0	-1.5	-1.8	-1.5	1.7	-1.8	-1.7	-0.9	-2.7	1.4
Delay discounting total patch changes 18 sec	1.8	2.4	3.5	-1.3	-1.9	-1.5	1.9	-1.5	-1.7	-1.2	-1.2	1.6
Delay discounting total patch changes 24 sec	2.1	2.6	4.5	-1.2	-2.1	-1.6	1.5	-1.6	-1.9	-1.5	-1.1	1.6
Delay discounting total patch changes 6 sec	0.2	0.3	1.5	-0.5	-0.2	-0.3	0.1	-0.4	-0.5	-0.3	-1.2	0.5
Delay discounting time to switch 0 sec	0.0	0.1	0.3	-0.6	-0.3	-0.1	0.1	-0.1	-0.0	-0.1	0.1	-0.3
Delay discounting water rate 0 sec	1.5	2.3	6.2	2.1	-0.5	-0.6	1.8	-1.3	-1.0	-1.7	-0.8	2.5
Delay discounting water rate 12 sec	1.9	2.8	5.3	1.0	-1.6	-1.7	1.6	-1.7	-1.8	-2.3	-1.0	2.0
Delay discounting water rate 18 sec	0.2	0.3	1.8	1.3	0.4	0.5	-0.5	0.2	0.5	-0.1	0.4	0.3
Delay discounting water rate 24 sec	2.4	3.3	6.8	2.2	-0.9	-0.8	2.5	-1.4	-1.3	-2.4	0.2	2.6
Delay discounting water rate 6 sec	3.8	5.5	11.5	2.5	-1.7	-1.5	2.9	-2.1	-1.9	-3.1	-0.3	3.4
Locomotor activity	3.3	5.3	10.4	2.4	-1.0	-1.5	3.1	-2.2	-2.1	-2.7	-1.5	3.2
Locomotor testing distance	1.3	2.2	5.2	2.3	-0.2	-0.5	1.8	-1.3	-0.9	-1.8	-1.3	2.0
Locomotor testing rearing	0.6	0.9	2.2	1.0	0.0	-0.6	1.4	-1.0	-0.9	-0.9	-0.5	1.5
Light reinforcement 1	0.0	0.1	0.3	0.5	-0.4	-0.1	-0.1	-0.3	0.2	-0.3	0.1	-0.2
Light reinforcement 2	0.7	0.9	1.7	1.0	0.6	1.0	-0.7	1.2	0.9	0.5	1.3	-0.8
Reaction time number correct	0.2	0.3	1.2	0.7	0.9	0.4	0.2	0.1	0.1	0.1	-1.1	-0.1
Reaction time mean minus median	0.8	1.0	3.9	-0.8	0.7	0.4	-1.3	0.7	0.7	1.1	0.4	-2.0
Reaction time mean minus median AUC	0.6	0.7	2.9	-0.8	0.4	-0.1	-1.2	0.3	0.5	1.0	-0.3	-1.7
Reaction time num false alarms	0.6	0.8	2.0	-1.4	0.2	0.3	-1.4	0.6	0.5	1.0	0.1	-1.4
Reaction time num false alarms AUC	0.9	1.3	3.2	-1.0	0.8	0.6	-1.8	0.9	0.9	1.5	0.2	-1.7
Reaction time trials correct on left	0.2	0.3	1.2	0.7	0.9	0.4	0.2	0.1	0.1	0.1	-1.1	-0.1
Reaction time trials on left	0.2	0.3	1.2	0.7	0.9	0.4	0.0	0.2	0.1	0.2	-1.1	-0.3
Reaction time mean	0.1	0.2	1.0	1.0	0.7	0.2	-0.1	0.1	0.3	-0.3	-0.0	-0.4
Reaction time mean AUC	0.1	0.1	0.7	0.8	0.4	-0.1	0.0	-0.1	-0.1	-0.5	-0.0	-0.1
Median of all reaction times	0.3	0.5	2.4	1.5	0.4	0.0	0.6	-0.3	-0.1	-0.8	-0.1	0.6
Reaction time omissions	4.2	5.7	15.9	0.1	2.0	1.7	-4.0	2.1	2.3	2.3	0.8	-3.6
Reaction time false alarm rate	0.8	1.1	2.8	-1.1	0.3	0.5	-1.7	0.9	0.8	1.2	0.9	-1.4
Reaction time premature initiation rate	0.3	0.4	1.4	0.7	0.6	0.9	0.2	0.2	0.7	0.1	-1.2	-0.5
Reaction time premature initiations	0.4	0.5	3.1	0.7	0.6	0.5	0.3	-0.1	0.2	-0.0	-1.8	-0.5
Std. dev. reaction times	1.0	1.3	4.7	-0.4	1.1	0.5	-1.7	0.8	0.8	1.2	0.1	-2.2
Reaction time trials completed	0.2	0.3	1.2	0.7	0.9	0.4	0.0	0.2	0.1	0.2	-1.1	-0.3
Reaction time trials AUC	0.2	0.4	1.3	0.9	0.9	0.4	0.2	0.2	0.1	0.1	-1.1	-0.1
Social response proportion	1.2	1.3	7.2	2.7	0.8	-0.0	1.2	-0.3	-0.7	-0.8	-0.5	0.9
Social responses	0.7	1.0	3.0	1.4	0.3	-0.4	1.2	-0.9	-0.6	-0.4	-1.7	0.7
Social time	0.9	1.2	3.8	0.7	-0.1	-1.1	1.0	-1.2	-1.3	-0.9	-1.9	0.8
Conditioned locomotion	0.1	0.1	0.2	-0.1	0.3	0.3	-0.3	0.4	0.3	0.0	0.3	-0.5
Cocaine response after cond. corrected	0.3	0.4	1.3	0.0	0.1	-0.8	-0.0	-0.5	-1.1	-0.7	0.3	0.8
Cocaine response after cond. not corrected	0.4	0.5	1.6	0.2	0.1	-0.9	0.1	-0.6	-1.3	-0.8	0.4	0.8
Cocaine response before conditioning	0.0	0.0	0.1	0.1	-0.2	-0.1	-0.3	-0.2	0.2	0.2	0.2	-0.2
Saline control response	0.8	1.0	1.6	-0.3	-0.7	-1.1	1.3	-1.1	-1.3	-1.2	-0.5	1.1
Condit. Reinf. active minus inactive responses	0.8	1.0	1.9	-0.5	-0.1	0.8	-1.0	0.4	1.4	1.2	-1.3	-1.4
Condit. Reinf. active-inactive response ratio	0.3	0.4	1.2	-1.0	-0.4	0.0	-0.3	-0.1	0.3	0.5	-1.1	-0.7
Condit. Reinf. active responses	0.7	1.0	2.7	0.0	0.3	1.0	-1.3	0.5	1.6	1.2	-0.7	-1.2
Condit. Reinf. inactive responses	1.3	1.6	3.6	0.7	1.1	1.2	-1.9	1.0	1.7	1.3	0.6	-1.1
Condit. Reinf. lever presses	0.3	0.4	1.0	-0.2	-0.0	0.6	-0.2	0.2	1.0	0.6	-1.0	-0.7
Condit. Reinf. lever reinforcers received	0.8	1.2	3.4	0.4	0.3	1.2	-1.3	0.7	1.8	1.1	-0.6	-1.3
Pavlov. Cond. lever latency	0.4	0.6	1.6	-1.0	-0.4	-1.1	-0.2	-0.5	-1.2	-0.5	0.7	0.8
Pavlov. Cond. magazine entry latency	0.2	0.3	0.8	0.1	-0.9	-0.6	-0.1	-0.7	-0.3	-0.6	-0.4	0.1
Pavlov. Cond. change in total contacts	1.1	1.5	4.7	2.2	-0.3	0.1	2.1	-0.6	-0.3	-1.4	-0.4	1.2
Pavlov. Cond. index score	0.3	0.4	1.5	1.2	-0.4	-0.1	0.7	-0.5	0.1	-0.8	-0.6	0.3
Pavlov. Cond. latency score	0.2	0.2	0.9	0.9	-0.4	0.1	0.5	-0.3	0.3	-0.6	-0.6	0.1
Pavlov. Cond. lever contacts	0.7	1.0	3.4	1.8	0.6	1.1	0.6	0.3	1.2	0.1	-1.3	-0.2
Pavlov. Cond. magazine entry number	0.4	0.5	2.2	-1.5	0.6	0.1	-0.5	0.6	-0.2	1.0	0.5	-0.5
Pavlov. Cond. intertrial magazine entries	0.4	0.5	2.3	-1.1	0.1	-0.1	-1.5	0.1	0.2	0.7	0.1	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.1	1.0	-0.6	-0.4	0.9	-0.8	-0.2	-1.0	-0.7	0.5
Pavlov. Cond. response bias	0.6	0.8	4.0	2.0	0.2	0.5	0.8	-0.2	0.6	-0.5	-1.3	0.3
Conditioned reinforcement - actives	1.6	1.6	2.5	-0.0	-1.1	-1.5	1.6	-1.6	-1.4	-1.2	-1.4	0.8
Conditioned reinforcement - inactives	1.6	1.8	3.8	0.1	-0.9	-1.2	1.9	-1.4	-1.5	-1.2	-1.5	1.4
Conditioned locomotion	1.6	1.9	2.9	0.2	-1.2	-1.7	1.7	-1.6	-1.7	-1.6	-0.5	1.1
Intermittent access intake day 1-15 change	2.9	2.9	4.7	-0.4	-1.6	-1.9	1.8	-2.1	-1.6	-1.1	-1.9	2.2
Intermittent access intake escalation	3.5	3.5	6.2	-0.6	-1.7	-2.0	1.8	-2.4	-1.7	-1.1	-2.5	2.1
Intermittent access intake escalation 2	1.0	1.0	2.4	-0.2	-0.9	-0.9	1.6	-1.1	-0.9	-0.3	-0.8	1.5
Intermitt. access day 1 inactive lever presses	1.5	1.6	4.3	-1.3	0.4	0.7	-2.1	0.9	1.1	1.4	-0.1	-2.0
Intermitt. access day 15 inactive lever presses	0.7	0.8	2.2	-0.7	1.0	0.9	-0.7	0.8	0.8	1.5	0.4	-0.8
Intermitt. access escalation Index	1.7	1.5	5.0	-0.6	0.4	0.8	-2.2	0.9	1.3	1.2	-0.2	-1.9
Intermittent access day 1 total infusions	1.9	2.1	4.3	1.0	-1.0	-1.6	1.6	-1.3	-1.8	-2.1	0.4	1.5
Intermittent access day 15 total infusions	4.6	5.2	8.3	0.8	-1.9	-2.5	2.7	-2.4	-2.7	-2.6	-0.7	2.9
Intermittent access terminal intake (last 3 days)	4.1	4.5	7.7	1.3	-1.5	-2.2	2.6	-2.1	-2.4	-2.5	-0.3	2.8
Intermittent access total infusions	4.2	4.6	8.3	1.4	-1.4	-2.1	2.8	-2.0	-2.4	-2.7	-0.0	2.9
Intermittent access day 1 locomotion	1.5	1.5	2.8	0.8	-0.7	-1.2	1.5	-0.7	-1.6	-1.7	1.0	1.4
Intermittent access day 15 total locomotion	5.0	5.3	9.1	-0.6	-2.2	-2.8	2.9	-2.3	-3.0	-2.2	-0.1	2.7
Intermittent access total locomotion	3.2	3.6	6.1	0.6	-1.4	-1.9	2.5	-1.5	-2.4	-2.4	1.0	2.4
Intermittent access standard deviation	5.1	5.4	9.6	0.2	-2.3	-2.4	3.1	-2.6	-2.6	-2.4	-1.2	2.8
Cocaine induced anxiety	1.9	2.2	3.3	0.2	1.8	1.7	-1.2	1.8	1.6	1.5	1.1	-1.7
Post-drug Anxiety	2.0	2.2	3.6	-0.8	1.2	1.3	-1.9	1.5	1.5	1.7	1.1	-1.9
Baseline Anxiety	0.7	0.7	1.7	-1.3	-1.3	-1.0	-0.1	-0.9	-0.7	-0.3	-0.4	0.7
Lifetime Intake	3.0	3.3	6.3	1.6	-0.9	-1.6	2.5	-1.6	-1.9	-2.3	0.0	2.5
Incentive Sensitization - Responses	3.8	3.8	6.3	-0.2	-2.0	-2.5	1.9	-2.4	-2.5	-1.9	-1.1	1.8
Incentive Sensitization - Breakpoint	3.3	3.4	5.8	-0.3	-1.9	-2.4	1.7	-2.3	-2.4	-1.8	-0.9	1.7
Progressive ratio test 1 active lever presses	7.0	7.3	15.0	1.3	-2.1	-2.8	3.0	-2.6	-3.2	-3.9	-0.8	3.0
Progressive ratio test 1 breakpoint	6.3	6.5	13.2	1.4	-2.0	-2.6	2.8	-2.5	-3.0	-3.6	-0.9	2.8
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.6	-0.4	-0.5	-0.6	0.4	-0.5	-0.6	-0.8	-0.5	0.2
Progressive ratio test 2 active lever presses	3.8	4.0	6.3	0.5	-1.8	-2.4	2.1	-2.3	-2.5	-2.4	-0.9	2.1
Progressive ratio test 2 breakpoint	4.8	5.3	7.6	0.6	-2.1	-2.7	2.5	-2.6	-2.8	-2.7	-1.3	2.5
Progressive ratio test 2 inactive lever presses	0.5	0.6	1.1	-0.3	-0.8	-0.9	1.0	-0.8	-1.0	-0.8	-0.6	0.6
Total sessions with >9 infusions	1.2	1.4	3.5	1.5	-0.5	-0.8	1.4	-0.7	-1.2	-1.9	0.5	1.2
Short access day 1 total inactive lever presses	0.1	0.1	0.9	0.1	0.2	0.0	0.2	0.1	-0.0	-0.0	0.9	-0.1
Short access day 10 total inactive lever presses	5.1	5.6	12.9	-2.2	1.2	1.3	-3.6	1.6	2.4	2.9	0.6	-3.5
Short access day 1 total infusions	0.7	0.7	2.1	1.1	-0.6	-0.8	0.6	-0.8	-0.8	-1.4	0.1	0.7
Short access day 10 total infusions	4.0	4.4	8.7	1.6	-1.3	-1.7	2.9	-1.8	-2.2	-2.8	-0.5	2.9
Short access total infusions	2.5	2.7	5.2	1.7	-0.8	-1.3	2.1	-1.5	-1.5	-2.3	-0.7	2.2
Short access day 1 locomotion	1.4	1.5	3.5	0.2	-1.4	-1.5	0.7	-1.4	-1.4	-1.9	-0.9	0.8
Short access day 10 total locomotion	0.2	0.2	0.4	0.3	-0.3	-0.2	0.5	-0.1	-0.4	-0.6	0.7	0.3
Short access total locomotion	2.2	2.2	4.0	0.1	-1.5	-1.6	1.7	-1.5	-1.8	-2.0	-1.0	1.4
Compulsive drug intake	2.4	2.4	6.5	-1.0	1.1	1.0	-2.2	1.2	1.3	1.7	-1.0	-2.6
One hour access (0.3 mA shock)	4.8	5.5	12.1	0.6	-1.8	-2.3	3.5	-2.4	-2.6	-2.2	-1.2	3.2
One hour access (shock baseline)	6.5	7.5	16.1	0.6	-2.2	-2.6	4.0	-2.8	-3.0	-2.6	-0.4	4.0
Number of responses in last shaping day	1.1	1.1	1.8	0.3	-1.1	-1.1	1.2	-1.0	-1.3	-1.3	-0.4	1.0
Context. condit. distance diff. score	0.5	0.7	3.0	0.9	0.2	-0.2	0.7	0.1	-0.5	-0.9	1.7	0.7
Locomotion velocity, session 1	0.8	0.8	1.9	-0.7	0.4	0.7	-0.6	0.4	1.1	1.4	-1.2	-1.2
Locomotion distance, session 1	0.2	0.3	0.9	0.4	0.3	0.5	0.8	0.1	0.5	0.3	-0.9	-0.2
Locomotion velocity, session 2	0.3	0.3	1.1	-1.1	-0.4	0.1	0.0	0.4	0.1	0.5	1.0	-0.4
Locomotion distance, session 2	0.4	0.6	2.5	0.9	-0.2	0.0	1.6	-0.4	-0.2	-0.5	-1.1	0.6
Locomotion velocity, session 3	0.3	0.4	0.7	-0.5	0.4	0.4	0.7	0.6	0.1	0.8	0.8	-0.7
Locomotion distance, session 3	0.6	0.6	3.0	1.3	0.1	0.4	1.7	0.1	-0.2	-0.4	0.4	0.8
Stereotopy head waving bouts, day 3	0.4	0.5	1.7	-1.1	-0.2	0.4	0.0	0.6	0.3	1.0	-0.3	-1.3
Stereotopy head waving duration, day 3	0.4	0.5	1.4	-1.2	0.0	0.0	-0.5	0.4	0.1	0.9	-0.1	-1.2
Locomotion velocity, session 7	0.2	0.2	0.5	0.3	-0.2	0.5	0.7	0.1	0.6	0.1	-0.6	-0.2
Locomotion distance, session 7	0.1	0.2	0.3	0.5	0.3	0.5	0.6	0.3	0.5	0.3	-0.1	-0.4
Stereotopy head waving bouts, day 7	0.4	0.5	1.7	-1.1	-0.4	-0.2	1.0	-0.4	-0.1	0.4	-1.3	-0.1
Stereotopy head waving duration, day 7	0.2	0.3	1.5	-0.5	0.0	0.0	0.5	-0.2	0.1	0.6	-1.2	-0.2
Locomotion velocity, session 8	0.4	0.5	1.8	-0.9	-0.6	-0.8	-0.3	-0.3	-0.6	-0.1	1.3	0.0
Locomotion distance, session 8	1.7	2.5	8.6	1.9	-0.4	-0.6	2.9	-0.8	-1.3	-1.9	0.5	2.0
Degree of sensitization distance	0.4	0.4	1.6	-0.5	0.4	0.2	-1.2	0.3	0.5	0.5	0.3	-0.9
Degree of sensitization stereotypy	0.2	0.2	0.5	-0.6	0.2	0.3	0.2	0.2	0.5	0.7	-0.6	-0.4
Condit. Reinf. active minus inactive responses	1.5	1.7	3.6	-0.5	0.8	1.0	-1.4	0.5	1.6	1.9	-1.6	-1.5
Condit. Reinf. active-inactive response ratio	1.3	1.4	2.8	0.2	0.9	1.1	-1.4	0.6	1.5	1.7	-1.4	-1.2
Condit. Reinf. active responses	2.0	2.5	5.3	-1.4	0.7	1.1	-1.7	0.6	1.8	2.3	-1.8	-1.9
Condit. Reinf. inactive responses	1.1	1.3	2.4	-1.5	0.5	0.7	-1.3	0.6	1.1	1.5	-0.7	-1.5
Incentive salience index mean	1.0	1.2	6.5	-1.0	0.1	0.3	-0.3	-0.4	0.9	1.2	-2.6	-0.7
Condit. Reinf. lever presses	0.7	0.9	5.3	-1.0	-0.4	-0.1	1.1	-0.8	0.0	0.3	-2.3	0.2
Time in familiar zone, hab. session 1	0.4	0.4	0.8	-0.1	0.3	0.6	-0.9	0.5	0.9	0.7	0.5	-0.6
Time in novel zone, hab. session 1	0.4	0.4	1.8	1.3	0.8	0.4	-0.5	0.6	0.2	0.0	0.5	-0.2
Total zone transitions, hab. session 1	1.6	2.3	7.4	0.5	-0.9	-0.5	2.6	-1.5	-0.6	-1.0	-2.7	1.2
Total locomotion distance, hab. session 1	1.3	1.8	6.1	-0.0	-0.7	-0.7	2.2	-1.6	-0.4	-0.8	-2.5	1.1
Locomotion velocity, hab. session 1	2.1	3.0	9.8	-0.3	-1.1	-1.1	2.6	-2.1	-0.7	-1.1	-3.1	1.3
Time in familiar zone, hab. session 2	0.2	0.2	0.9	-0.2	-0.1	0.0	-1.0	-0.0	0.3	0.0	-0.5	-0.3
Time in novel zone, hab. session 2	0.8	0.8	1.5	1.0	1.2	1.0	0.0	1.0	0.7	0.8	0.8	-0.8
Total zone transitions, hab. session 2	0.7	0.9	3.1	1.3	0.6	0.6	1.8	-0.2	0.4	-0.0	-1.6	0.3
Total locomotion distance, hab. session 2	0.7	0.9	3.8	1.1	0.8	0.4	1.2	-0.6	0.6	-0.0	-2.0	0.5
Locomotion velocity, hab. session 2	0.7	0.9	3.5	1.0	0.7	0.4	1.3	-0.6	0.6	-0.1	-1.9	0.5
Novel to familiar place preference ratio	0.7	0.8	3.3	-1.8	-1.4	-0.9	-0.6	-0.5	-0.3	0.2	0.2	-0.4
Novelty place preference	0.9	1.0	4.2	-2.1	-1.3	-0.7	-1.1	-0.3	-0.1	0.6	0.1	-0.8
Time in novel zone, NPP test	0.7	0.7	2.8	-1.7	-1.2	-0.7	-1.0	-0.3	-0.1	0.4	0.1	-0.6
Total zone transitions, NPP test	0.8	1.2	6.5	1.2	0.3	0.3	2.5	-0.4	-0.3	-0.7	-1.0	1.0
Total locomotion distance, NPP test	0.8	1.1	4.6	0.4	-0.0	-0.2	2.2	-0.9	-0.2	-0.7	-1.7	1.0
Locomotion velocity, NPP test	0.6	0.8	3.8	0.1	-0.0	-0.1	2.0	-0.7	-0.1	-0.5	-1.5	0.6
Pavlov. Cond. lever latency	0.9	1.1	5.3	2.3	0.7	0.3	0.1	0.5	-0.2	-0.7	1.7	0.8
Pavlov. Cond. magazine entry latency	0.4	0.6	2.4	-0.1	0.1	0.8	-0.1	0.2	1.1	0.7	-1.5	-0.6
Pavlov. Cond. change in total contacts	0.4	0.4	3.0	-0.3	-0.5	0.2	0.2	-0.3	0.6	0.1	-1.7	0.0
Pavlov. Cond. index score	0.7	0.9	4.5	-1.1	-0.2	0.4	0.1	-0.2	0.8	0.8	-2.1	-0.6
Pavlov. Cond. latency score	0.8	1.0	4.5	-1.5	-0.4	0.3	0.1	-0.3	0.6	0.8	-2.1	-0.7
Pavlov. Cond. lever contacts	1.2	1.4	5.0	-2.2	-1.0	-0.6	0.6	-1.0	-0.2	0.2	-2.2	-0.1
Pavlov. Cond. magazine entry number	0.4	0.5	2.1	-0.2	-0.4	-0.7	0.1	-0.1	-1.0	-0.5	1.4	0.4
Pavlov. Cond. intertrial magazine entries	1.1	1.3	6.7	2.6	1.5	0.9	-0.0	0.8	0.5	-0.1	1.1	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	4.7	-0.8	-0.1	0.5	0.3	-0.2	0.7	0.7	-2.2	-0.4
Pavlov. Cond. response bias	0.6	0.8	5.3	-0.8	-0.5	0.0	0.1	-0.6	0.5	0.3	-2.3	-0.2
Bone: apparent density	0.1	0.1	0.6	-0.4	0.2	-0.1	0.6	-0.0	-0.3	0.2	-0.8	-0.0
Bone surface	0.2	0.4	1.0	1.0	0.6	-0.2	0.6	-0.2	-0.6	-0.7	-0.4	0.8
Bone volume	0.2	0.3	0.6	0.5	0.5	-0.3	0.7	-0.3	-0.7	-0.6	-0.7	0.8
Bone: connectivity density	0.1	0.2	0.9	-0.9	0.1	-0.1	-0.2	0.3	-0.1	0.6	-0.1	-0.5
Bone: cortical apparent density	0.3	0.3	1.5	0.2	-0.3	-0.2	1.2	-0.4	-0.2	-0.7	0.4	0.7
Bone: cortical area	1.0	1.5	3.0	0.7	-0.5	-0.8	1.7	-1.0	-1.5	-1.6	-0.5	1.7
Bone: cortical porosity	0.2	0.2	0.9	-0.6	-0.2	-0.6	0.0	-0.2	-1.0	-0.1	-0.2	-0.1
Bone: cortical porosity	0.2	0.2	0.9	-0.0	0.1	-0.6	0.4	-0.4	-1.0	-0.3	-0.6	0.3
Bone: cortical thickness	1.0	1.6	3.7	-0.8	-1.1	-1.1	1.9	-1.1	-1.7	-1.1	-0.6	1.3
Bone: cortical thickness	0.2	0.2	0.5	-0.6	0.2	0.2	-0.4	0.3	0.2	0.7	-0.3	-0.7
Bone: cortical tissue density	0.2	0.3	1.2	0.2	-0.3	-0.2	1.1	-0.3	-0.1	-0.7	0.5	0.6
Bone: elastic displacement	3.9	4.4	12.7	-1.8	1.3	1.2	-3.6	1.6	1.7	2.8	0.4	-2.7
Bone: elastic work	2.0	2.6	7.3	-1.6	1.3	0.6	-2.7	1.3	0.8	2.0	0.8	-2.1
Bone: endosteal estimation	1.6	3.5	16.4	4.1	2.4	1.8	-0.7	1.5	1.1	-0.4	1.5	0.2
Bone: endosteal perimeter	1.2	2.4	11.5	3.4	0.4	0.0	0.7	-0.3	-0.7	-2.0	1.1	2.1
Bone: final force	0.5	0.9	4.2	2.1	0.4	0.5	1.3	0.3	-0.5	-0.8	-0.1	0.9
Bone: final moment	0.4	0.7	2.8	1.7	0.3	0.3	1.1	0.1	-0.6	-0.8	-0.6	0.7
Bone: marrow area	1.6	3.4	15.9	4.0	2.4	1.7	-0.7	1.5	1.1	-0.4	1.5	0.2
Bone: maximum diameter	1.0	1.7	5.7	2.4	-0.1	-0.3	0.9	-0.7	-0.9	-2.0	0.2	1.9
Bone: maximum force	0.3	0.6	3.2	1.8	0.8	0.7	0.4	0.6	-0.1	-0.3	0.4	0.3
Bone: maximum moment	0.2	0.4	1.9	1.4	0.8	0.6	0.2	0.5	-0.2	-0.1	-0.1	0.1
Bone: minimum diameter	2.1	3.8	8.7	3.0	-0.4	-0.8	2.2	-1.4	-1.6	-2.8	-0.3	2.8
Bone: periosteal estimation	0.9	1.8	9.3	3.0	1.3	0.6	0.5	0.5	-0.2	-1.3	1.1	1.2
Bone: periosteal perimeter	0.6	1.0	3.5	1.9	0.4	0.1	0.8	-0.2	-0.6	-1.3	0.5	1.4
Bone: post-yield work	0.1	0.2	0.9	0.9	0.2	0.2	0.2	0.3	-0.0	-0.4	0.8	-0.0
Bone: stiffness	1.7	2.8	10.6	3.3	0.1	0.4	2.5	-0.1	-0.8	-1.8	-0.4	1.9
Bone: tissue strength	0.5	0.5	2.1	0.6	-0.1	-0.0	1.5	-0.3	-0.6	-0.8	-0.8	0.5
Bone: trabecular number	0.1	0.1	0.3	-0.3	0.2	0.1	-0.1	0.3	0.0	0.6	-0.2	-0.4
Bone: trabecular spacing	0.3	0.4	1.8	-1.3	-0.2	-0.3	-1.0	-0.0	0.1	0.6	0.4	-0.8
Bone: trabecular thickness	0.2	0.2	0.4	-0.4	0.2	-0.5	0.1	-0.5	-0.5	-0.3	-0.6	0.5
Bone: trabecular tissue density	0.2	0.2	1.1	0.6	-0.3	0.4	1.1	0.1	0.2	-0.2	-0.3	0.4
Breakpoint value in progressive ratio session	1.6	1.8	3.3	-0.2	1.2	1.6	-1.5	1.3	1.8	1.5	-0.4	-1.5
Distance traveled before self-admin	0.1	0.1	0.2	-0.1	-0.2	-0.1	0.4	-0.3	-0.0	-0.2	-0.4	0.3
Distance traveled after self-admin	0.3	0.3	1.4	0.0	0.2	0.7	1.2	0.2	0.2	-0.1	0.0	0.8
Delta time in closed arm before/after self-admin	0.1	0.1	0.4	0.6	0.2	-0.3	-0.5	-0.4	0.1	-0.5	-0.0	-0.1
Delta time in open arm before/after self-admin	0.9	0.8	2.2	-1.0	0.6	1.1	-0.6	1.1	0.9	1.5	-0.4	-0.5
Diff in mean of infusions in LGA sessions	1.2	1.3	3.1	-0.9	0.8	0.8	-1.7	0.7	1.3	1.8	-0.3	-1.4
Extinction: sum of active levers before priming	0.5	0.6	0.9	0.6	0.9	0.8	-0.7	0.7	0.9	0.8	-0.3	-0.8
Active lever presses in extinction session 6	0.5	0.5	1.2	1.0	0.6	1.1	0.5	0.5	0.8	0.3	-1.0	0.2
Delta distance traveled before/after self-admin	0.1	0.2	0.8	-0.0	0.1	0.3	0.9	0.1	-0.1	-0.2	-0.2	0.6
Delta ambulatory time before/after self-admin	0.3	0.4	1.1	-0.0	0.8	1.1	0.6	0.8	0.6	0.6	0.0	0.2
Time in closed arm before self-admin	0.2	0.2	0.4	0.3	-0.6	-0.7	0.2	-0.6	-0.6	-0.6	-0.0	0.3
Time in closed arm after self-admin	0.2	0.2	1.0	0.7	0.3	0.0	-0.5	-0.0	0.2	-0.4	1.0	0.0
Time in open arm before self-admin	0.1	0.1	0.6	0.3	0.4	0.1	-0.2	0.1	0.2	0.2	0.4	-0.8
Time in open arm after self-admin	0.5	0.6	1.6	-0.7	0.4	0.7	-0.6	0.7	0.6	1.2	-0.6	-0.9
Sum of active levers in priming session hrs 5-6	0.9	0.9	6.2	-0.4	-0.4	-0.2	0.6	-0.8	0.1	0.1	-2.5	0.8
Time to tail flick, vehicle, before self-admin	4.5	4.5	9.1	-0.6	-3.0	-2.7	1.4	-2.7	-2.4	-2.3	-1.3	1.5
Time to tail flick, vehicle, after self-admin	1.0	1.0	2.5	-0.6	1.1	1.4	-0.3	0.9	1.4	1.6	-0.5	-0.4
Time to tail flick, test, before self-admin	0.2	0.2	0.6	0.2	-0.1	0.2	0.6	0.2	-0.4	-0.4	0.8	-0.2
Time to tail flick, test, after self-admin	0.0	0.0	0.0	0.2	-0.2	-0.0	0.2	-0.1	-0.1	0.1	-0.1	-0.0
Delta time to tail flick, vehicle, before/after SA	4.2	4.1	7.2	-0.2	2.6	2.6	-1.4	2.3	2.6	2.7	0.3	-1.3
Delta time to tail flick, test, before/after SA	0.1	0.1	0.5	0.2	0.0	-0.2	0.1	-0.4	0.1	0.4	-0.7	0.4
Ambulatory time before self-admin	0.1	0.1	0.3	-0.3	-0.5	-0.3	0.3	-0.3	-0.3	-0.4	0.1	0.2
Ambulatory time after self-admin	0.3	0.3	1.4	0.4	0.3	0.6	1.2	0.2	0.1	-0.2	0.2	1.0
Total heroin consumption	1.0	1.2	2.5	0.0	0.9	1.3	-1.1	1.0	1.6	1.0	-1.0	-1.1
Area under the delay curve	0.9	1.0	2.5	1.4	1.6	1.2	1.3	0.9	0.0	-0.1	0.2	0.6
Delay disc. indifference point, 0s delay	0.5	0.6	1.8	0.4	0.8	0.8	1.3	0.2	0.4	0.5	-1.0	0.7
Delay disc. indifference point, 16s delay	1.4	1.4	5.0	2.2	1.8	1.4	0.9	1.0	0.2	-0.6	0.5	0.5
Delay disc. indifference point, 2s delay	0.4	0.5	2.2	0.5	0.0	0.1	1.5	-0.2	-0.4	-0.6	-0.1	1.1
Delay disc. indifference point, 24s delay	0.6	0.6	1.6	1.1	1.1	0.3	0.3	0.6	-0.6	-0.7	1.2	-0.2
Delay disc. indifference point, 4s delay	0.2	0.2	0.5	0.4	0.7	-0.0	0.7	-0.1	-0.4	-0.1	0.1	0.6
Delay disc. indifference point, 8s delay	1.1	1.2	4.1	1.4	2.0	1.3	0.8	1.2	0.2	0.3	0.6	0.5
Delay discount exponential model param	0.7	0.8	1.9	-1.2	-1.4	-0.9	-1.2	-0.8	0.2	0.3	-0.5	-0.6
Delay discount hyperbolic model param	0.6	0.7	1.6	-1.1	-1.2	-0.7	-1.3	-0.6	0.3	0.3	-0.4	-0.7
Fecal boli incidents, locomotor time 1	0.2	0.2	0.9	0.2	-0.1	-0.0	0.6	0.1	-0.4	-0.4	1.0	0.1
Change in fecal boli incidents, locomotor task	1.6	1.5	2.9	0.7	1.1	1.5	-1.2	1.4	1.7	1.1	1.0	-1.0
Time >=10cm from walls, locomotor time 1	1.1	1.1	2.8	1.2	1.7	1.2	-0.8	1.0	1.2	0.8	0.3	-0.6
Bouts of movement, locomotor time 1	0.4	0.4	1.7	0.5	1.3	0.7	0.1	0.5	0.2	0.9	-0.5	-0.1
Total resting periods, locomotor time 1	0.4	0.5	2.0	0.4	1.4	0.5	0.0	0.4	0.3	1.2	-0.6	-0.2
Rest time, locomotor task time 1	1.1	1.2	3.2	-0.5	1.7	0.8	-0.9	0.9	0.9	1.8	-0.0	-1.0
Distance moved, locomotor task time 1	1.5	1.6	4.2	-1.0	-2.1	-0.9	1.1	-1.4	-0.7	-1.4	-1.5	1.1
Vertical activity count, locomotor time 1	1.6	1.7	4.4	0.3	-1.9	-0.9	0.7	-1.5	-0.8	-2.1	-1.4	0.8
Time >=10cm from walls, locomotor time 2	0.8	0.9	4.7	-0.8	0.1	-0.2	-0.7	-0.4	0.3	1.2	-2.2	-0.7
Bouts of movement, locomotor time 2	0.3	0.4	1.0	0.9	0.6	0.2	0.6	0.2	-0.2	0.3	0.8	1.0
Total resting periods, locomotor time 2	0.5	0.5	1.2	1.1	1.1	0.5	0.4	0.5	0.1	0.5	0.7	0.9
Rest time, locomotor task time 2	1.8	2.1	5.0	1.2	2.2	1.6	-1.1	1.5	1.7	1.4	0.9	-0.8
Distance moved, locomotor task time 2	2.0	2.3	4.8	-2.2	-2.2	-1.4	0.7	-1.7	-1.1	-0.9	-1.7	1.0
Vertical activity count, locomotor time 2	4.4	4.8	8.1	-1.1	-2.8	-2.1	1.7	-2.5	-2.1	-2.5	-2.5	1.7
Weight adjusted by age	0.6	0.6	2.0	-0.0	-0.4	-0.3	1.4	-0.7	-0.1	0.2	-1.4	1.0
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.9	-0.9	-0.1	0.1	-0.0	0.1	-0.2	0.0	-1.0	-0.6
Locomotion in novel chamber	0.2	0.2	0.9	1.0	0.2	0.2	-0.6	0.3	-0.1	-0.3	-0.2	-0.6
Locomotion in novel chamber post-restriction	0.3	0.3	0.8	0.4	-0.3	-0.7	0.1	-0.2	-0.8	-0.9	0.8	0.5
Progressive ratio	1.1	1.3	2.4	-0.3	1.1	1.3	-0.6	1.5	1.0	1.3	1.6	-1.1
Food seeking constrained by brief footshock	2.2	2.7	4.0	-0.7	-1.9	-1.6	1.9	-1.6	-1.9	-1.8	-0.7	2.0
Seeking ratio, punishment vs. effort	1.6	2.0	3.0	-0.2	-1.5	-1.6	1.1	-1.7	-1.5	-1.6	-1.3	1.6
Run reversals in cocaine runway, females	0.4	0.4	1.4	0.6	0.5	-0.1	1.2	-0.1	-0.6	-0.7	0.4	0.9
Run reversals in cocaine runway, males	0.2	0.2	1.3	0.3	-0.0	-0.0	0.2	-0.3	0.2	0.1	-1.1	0.2
Latency to leave start box in cocaine runway	0.2	0.2	1.2	0.6	0.0	-0.3	-0.5	-0.5	0.1	-0.1	-1.1	-0.5
Latency to leave start box in cocaine runway, F	0.4	0.5	1.7	0.6	0.5	0.7	-0.5	0.2	1.3	0.8	-0.7	-0.4
Latency to leave start box in cocaine runway, M	1.7	1.7	4.4	-0.3	-1.4	-2.0	0.1	-1.4	-2.1	-1.6	-0.5	-0.0
Cd content in liver	0.5	0.6	3.1	1.8	0.3	0.2	0.5	-0.1	-0.1	-0.7	-0.6	0.8
Co content in liver	2.1	2.5	5.2	-0.5	-2.3	-1.8	1.2	-1.7	-1.7	-1.9	-0.2	1.7
Cu content in liver	0.6	0.7	1.7	-0.1	-1.1	-1.0	0.2	-0.8	-1.0	-1.3	0.3	1.1
Fe content in liver	0.6	0.8	3.0	1.7	0.4	0.4	1.1	0.4	-0.3	-0.7	1.1	0.5
K content in liver	1.4	1.4	4.1	-2.0	-1.7	-1.3	0.8	-0.9	-1.2	-0.6	-0.6	-0.0
Mg content in liver	0.1	0.1	0.3	-0.5	-0.3	-0.5	0.4	-0.4	-0.3	-0.2	-0.6	0.1
Mn content in liver	0.3	0.3	0.6	0.7	-0.8	-0.3	0.5	-0.4	-0.3	-0.8	-0.5	0.6
Na content in liver	0.3	0.3	1.8	-0.7	-1.3	-0.4	0.2	-0.2	-0.3	-0.2	0.0	0.2
Rb content in liver	0.4	0.6	1.8	-1.3	-0.5	-0.4	-0.5	0.4	-0.7	0.1	1.3	-0.1
Se content in liver	0.4	0.5	1.3	1.1	0.4	0.8	0.6	0.5	0.9	-0.1	0.8	0.1
Sr content in liver	0.7	0.7	3.3	-1.1	-0.3	-0.2	1.0	-0.3	-0.6	0.2	-1.8	0.1
Zn content in liver	0.3	0.4	1.0	-0.7	-0.0	-1.0	-0.1	-0.7	-0.8	-0.5	0.2	0.5