Hub : Genes

Adrb1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression ENSRNOG00000017002 0.18 0.09 6.1e-12 0.08 0.11 0.09 0.11 9.4e-07 2.1e-08 3.0e-07 2.7e-08
2 OFC alternative polyA ENSRNOT00000022813 0.14 0.09 9.6e-03 0.09 0.06 0.07 0.06 3.3e-03 1.8e-02 9.1e-03 1.8e-02
3 OFC alternative polyA ENSRNOT00000102657 0.14 0.09 8.7e-03 0.08 0.06 0.06 0.04 5.6e-03 2.0e-02 1.4e-02 4.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail2.89.223.6-4.91.4-1.4
BMI without tail1.02.15.3-2.30.7-0.7
Body weight3.414.333.3-5.82.2-2.2
Epididymis fat weight5.613.125.8-5.12.6-2.6
Glucose1.92.96.9-2.61.0-1.0
Heart weight1.31.84.9-2.20.5-0.5
Left kidney weight2.77.813.3-3.6-2.22.2
Right kidney weight3.49.723.9-4.9-1.61.6
Tail length0.10.30.5-0.30.7-0.7
Length with tail0.93.37.6-2.81.1-1.1
Length without tail2.45.212.9-3.61.1-1.1
Liver weight, left2.43.84.7-2.21.8-1.8
Liver weight, right2.64.310.5-3.21.1-1.1
Parametrial fat weight5.711.112.1-3.03.5-3.5
Retroperitoneal fat weight4.916.333.9-5.82.7-2.7
Intraocular pressure2.94.14.8-2.21.9-1.9
Extensor digitorum longus weight0.41.72.3-0.51.5-1.5
Soleus weight1.54.312.9-3.60.0-0.0
Tibialis anterior weight0.20.81.10.11.1-1.1
Tibia length0.82.36.8-2.6-0.10.1
Number of licking bursts0.60.81.10.11.1-1.1
Food consumed during 24 hour testing period0.30.40.50.4-0.70.7
Times rat made contact with spout0.40.40.7-0.8-0.50.5
Mean time between licks in bursts0.30.40.60.40.7-0.7
Mean num. licks in bursts1.51.82.2-1.0-1.51.5
Std. dev. time between licks in bursts0.20.30.50.70.3-0.3
Water consumed over 24 hours1.01.11.4-0.7-1.21.2
Indifference point 0 sec2.23.54.7-2.21.7-1.7
Indifference point AUC0.70.91.3-0.21.1-1.1
Indifference point function ln k0.10.10.2-0.3-0.40.4
Indifference point function log k0.10.10.2-0.3-0.40.4
Delay discounting total patch changes 0 sec2.33.74.2-2.11.9-1.9
Delay discounting total patch changes 12 sec1.41.92.7-0.51.6-1.6
Delay discounting total patch changes 18 sec2.83.74.8-1.32.2-2.2
Delay discounting total patch changes 24 sec2.93.75.2-0.82.3-2.3
Delay discounting total patch changes 6 sec3.35.15.1-2.32.3-2.3
Delay discounting time to switch 0 sec0.20.40.70.8-0.50.5
Delay discounting water rate 0 sec0.30.51.1-1.00.4-0.4
Delay discounting water rate 12 sec1.21.82.4-0.71.6-1.6
Delay discounting water rate 18 sec0.50.61.6-1.3-0.40.4
Delay discounting water rate 24 sec0.60.82.0-1.4-0.50.5
Delay discounting water rate 6 sec0.50.70.8-0.9-0.80.8
Locomotor activity0.71.13.3-1.8-0.00.0
Locomotor testing distance1.42.35.8-2.4-0.80.8
Locomotor testing rearing0.61.02.2-1.5-0.60.6
Light reinforcement 10.81.43.21.8-0.70.7
Light reinforcement 21.62.22.81.7-1.31.3
Reaction time number correct0.50.80.9-0.70.9-0.9
Reaction time mean minus median0.40.51.5-1.20.1-0.1
Reaction time mean minus median AUC0.70.91.9-1.4-0.70.7
Reaction time num false alarms0.00.10.10.1-0.30.3
Reaction time num false alarms AUC0.20.30.4-0.2-0.60.6
Reaction time trials correct on left0.50.80.9-0.70.9-0.9
Reaction time trials on left0.60.80.9-0.80.9-0.9
Reaction time mean0.30.41.2-1.1-0.20.2
Reaction time mean AUC0.10.20.4-0.7-0.10.1
Median of all reaction times0.30.51.0-1.0-0.40.4
Reaction time omissions0.20.30.3-0.50.5-0.5
Reaction time false alarm rate0.30.40.50.4-0.70.7
Reaction time premature initiation rate0.81.11.7-1.3-0.90.9
Reaction time premature initiations0.91.33.5-1.9-0.50.5
Std. dev. reaction times1.01.44.1-2.00.2-0.2
Reaction time trials completed0.60.80.9-0.80.9-0.9
Reaction time trials AUC0.60.80.9-0.90.9-0.9
Social response proportion2.52.75.0-2.2-1.21.2
Social responses2.53.27.3-2.71.1-1.1
Social time1.01.33.9-2.0-0.20.2
Conditioned locomotion0.00.00.10.1-0.20.2
Cocaine response after cond. corrected2.83.24.60.6-2.12.1
Cocaine response after cond. not corrected1.92.12.71.0-1.61.6
Cocaine response before conditioning1.41.82.21.01.5-1.5
Saline control response0.30.50.5-0.5-0.70.7
Condit. Reinf. active minus inactive responses2.93.65.1-0.82.3-2.3
Condit. Reinf. active-inactive response ratio1.11.11.6-0.11.3-1.3
Condit. Reinf. active responses4.46.28.2-1.42.9-2.9
Condit. Reinf. inactive responses2.42.93.8-1.12.0-2.0
Condit. Reinf. lever presses1.01.42.1-0.31.4-1.4
Condit. Reinf. lever reinforcers received3.34.76.3-1.22.5-2.5
Pavlov. Cond. lever latency1.11.52.30.1-1.51.5
Pavlov. Cond. magazine entry latency0.50.60.7-0.50.9-0.9
Pavlov. Cond. change in total contacts1.41.92.6-0.71.6-1.6
Pavlov. Cond. index score0.91.21.4-0.91.2-1.2
Pavlov. Cond. latency score0.91.21.5-0.71.2-1.2
Pavlov. Cond. lever contacts0.50.70.9-0.41.0-1.0
Pavlov. Cond. magazine entry number0.40.50.60.5-0.80.8
Pavlov. Cond. intertrial magazine entries0.10.10.10.00.4-0.4
Pavlov. Cond. lever-magazine prob. diff.0.81.01.0-1.01.0-1.0
Pavlov. Cond. response bias0.81.11.4-0.61.2-1.2
Conditioned reinforcement - actives1.41.41.9-0.6-1.41.4
Conditioned reinforcement - inactives0.40.51.0-1.00.5-0.5
Conditioned locomotion1.41.62.4-0.3-1.61.6
Intermittent access intake day 1-15 change1.71.62.6-1.61.1-1.1
Intermittent access intake escalation1.81.85.4-2.30.1-0.1
Intermittent access intake escalation 21.11.12.9-1.7-0.50.5
Intermitt. access day 1 inactive lever presses1.41.52.0-0.81.4-1.4
Intermitt. access day 15 inactive lever presses0.10.10.2-0.40.2-0.2
Intermitt. access escalation Index0.00.00.00.00.1-0.1
Intermittent access day 1 total infusions0.00.00.1-0.3-0.00.0
Intermittent access day 15 total infusions0.60.72.1-1.40.1-0.1
Intermittent access terminal intake (last 3 days)0.30.31.0-1.00.0-0.0
Intermittent access total infusions0.70.72.2-1.5-0.00.0
Intermittent access day 1 locomotion0.90.91.3-0.3-1.21.2
Intermittent access day 15 total locomotion1.31.43.4-1.80.7-0.7
Intermittent access total locomotion1.41.61.9-1.4-1.21.2
Intermittent access standard deviation1.71.82.5-0.51.6-1.6
Cocaine induced anxiety3.54.05.42.3-1.81.8
Post-drug Anxiety1.41.51.71.0-1.31.3
Baseline Anxiety3.23.45.1-2.31.6-1.6
Lifetime Intake0.80.82.5-1.6-0.10.1
Incentive Sensitization - Responses0.90.92.2-1.50.5-0.5
Incentive Sensitization - Breakpoint1.01.12.3-1.50.7-0.7
Progressive ratio test 1 active lever presses1.11.22.2-1.5-0.80.8
Progressive ratio test 1 breakpoint0.50.51.0-1.0-0.50.5
Progressive ratio test 1 inactive lever presses0.10.10.2-0.4-0.00.0
Progressive ratio test 2 active lever presses1.51.64.7-2.2-0.20.2
Progressive ratio test 2 breakpoint1.31.44.2-2.0-0.10.1
Progressive ratio test 2 inactive lever presses1.21.41.5-1.11.2-1.2
Total sessions with >9 infusions4.14.511.4-3.4-1.01.0
Short access day 1 total inactive lever presses0.10.10.2-0.40.3-0.3
Short access day 10 total inactive lever presses0.60.60.7-0.70.8-0.8
Short access day 1 total infusions0.91.01.6-1.3-0.80.8
Short access day 10 total infusions0.50.60.7-0.9-0.70.7
Short access total infusions0.80.81.7-1.3-0.60.6
Short access day 1 locomotion0.70.71.3-1.2-0.60.6
Short access day 10 total locomotion1.11.21.3-1.0-1.11.1
Short access total locomotion3.03.13.4-1.5-1.81.8
Compulsive drug intake0.80.80.80.90.9-0.9
One hour access (0.3 mA shock)1.82.12.5-1.11.6-1.6
One hour access (shock baseline)1.11.23.7-1.90.0-0.0
Number of responses in last shaping day0.20.20.4-0.6-0.40.4
Context. condit. distance diff. score0.91.11.61.3-0.90.9
Locomotion velocity, session 10.20.20.30.2-0.50.5
Locomotion distance, session 11.92.53.4-0.9-1.81.8
Locomotion velocity, session 23.03.55.0-0.7-2.22.2
Locomotion distance, session 21.52.23.2-1.8-1.31.3
Locomotion velocity, session 31.41.72.2-0.8-1.51.5
Locomotion distance, session 32.42.63.7-0.7-1.91.9
Stereotopy head waving bouts, day 30.20.30.3-0.30.6-0.6
Stereotopy head waving duration, day 30.60.71.00.31.0-1.0
Locomotion velocity, session 70.10.20.2-0.30.4-0.4
Locomotion distance, session 70.10.10.20.3-0.40.4
Stereotopy head waving bouts, day 70.30.40.5-0.10.7-0.7
Stereotopy head waving duration, day 70.80.91.0-0.91.0-1.0
Locomotion velocity, session 81.21.52.81.7-0.90.9
Locomotion distance, session 81.62.33.30.6-1.81.8
Degree of sensitization distance2.22.32.61.61.5-1.5
Degree of sensitization stereotypy0.30.30.5-0.00.7-0.7
Condit. Reinf. active minus inactive responses0.20.30.4-0.2-0.60.6
Condit. Reinf. active-inactive response ratio0.00.00.00.1-0.20.2
Condit. Reinf. active responses0.30.41.2-1.1-0.00.0
Condit. Reinf. inactive responses0.70.91.9-1.40.6-0.6
Incentive salience index mean0.50.60.9-0.2-1.01.0
Condit. Reinf. lever presses0.30.40.5-0.3-0.70.7
Time in familiar zone, hab. session 10.10.10.1-0.3-0.30.3
Time in novel zone, hab. session 10.60.60.8-0.10.9-0.9
Total zone transitions, hab. session 10.91.33.0-1.7-0.70.7
Total locomotion distance, hab. session 10.00.00.10.2-0.20.2
Locomotion velocity, hab. session 10.10.20.20.3-0.50.5
Time in familiar zone, hab. session 23.43.55.3-0.32.3-2.3
Time in novel zone, hab. session 22.42.53.6-0.4-1.91.9
Total zone transitions, hab. session 21.31.63.1-1.8-1.01.0
Total locomotion distance, hab. session 20.40.50.6-0.7-0.80.8
Locomotion velocity, hab. session 20.40.60.8-0.5-0.90.9
Novel to familiar place preference ratio0.40.40.60.30.8-0.8
Novelty place preference0.50.50.70.10.9-0.9
Time in novel zone, NPP test1.01.11.6-0.01.3-1.3
Total zone transitions, NPP test0.50.71.0-1.0-0.80.8
Total locomotion distance, NPP test0.20.20.3-0.2-0.60.6
Locomotion velocity, NPP test0.50.71.00.1-1.01.0
Pavlov. Cond. lever latency0.81.01.50.21.2-1.2
Pavlov. Cond. magazine entry latency0.00.10.2-0.4-0.10.1
Pavlov. Cond. change in total contacts0.30.30.5-0.2-0.70.7
Pavlov. Cond. index score0.20.20.3-0.5-0.40.4
Pavlov. Cond. latency score0.20.30.3-0.5-0.50.5
Pavlov. Cond. lever contacts0.20.20.3-0.2-0.50.5
Pavlov. Cond. magazine entry number0.40.51.41.20.2-0.2
Pavlov. Cond. intertrial magazine entries0.20.20.4-0.6-0.40.4
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.4-0.30.3
Pavlov. Cond. response bias0.30.40.5-0.7-0.60.6
Bone: apparent density2.03.34.6-0.82.1-2.1
Bone surface0.61.01.4-0.61.2-1.2
Bone volume1.72.83.1-1.51.8-1.8
Bone: connectivity density0.40.70.90.41.0-1.0
Bone: cortical apparent density4.45.88.3-0.8-2.92.9
Bone: cortical area4.16.213.4-3.71.6-1.6
Bone: cortical porosity0.80.81.20.21.1-1.1
Bone: cortical porosity1.31.42.00.31.4-1.4
Bone: cortical thickness2.03.39.2-3.00.6-0.6
Bone: cortical thickness0.91.13.1-1.8-0.10.1
Bone: cortical tissue density4.45.88.5-0.6-2.92.9
Bone: elastic displacement0.10.20.30.50.3-0.3
Bone: elastic work0.81.01.9-1.4-0.80.8
Bone: endosteal estimation0.71.62.2-1.51.1-1.1
Bone: endosteal perimeter2.14.310.6-3.31.0-1.0
Bone: final force1.32.26.5-2.50.2-0.2
Bone: final moment1.32.26.3-2.50.3-0.3
Bone: marrow area0.81.62.3-1.51.2-1.2
Bone: maximum diameter4.17.511.6-3.42.3-2.3
Bone: maximum force1.22.26.3-2.50.3-0.3
Bone: maximum moment1.22.16.0-2.40.4-0.4
Bone: minimum diameter1.52.84.3-2.11.4-1.4
Bone: periosteal estimation2.55.010.1-3.21.6-1.6
Bone: periosteal perimeter4.67.718.3-4.31.5-1.5
Bone: post-yield work0.20.30.40.40.6-0.6
Bone: stiffness0.91.54.4-2.10.0-0.0
Bone: tissue strength0.30.30.50.70.4-0.4
Bone: trabecular number1.52.33.40.11.8-1.8
Bone: trabecular spacing0.10.10.10.4-0.20.2
Bone: trabecular thickness3.54.24.3-2.02.1-2.1
Bone: trabecular tissue density1.41.92.2-1.5-1.31.3
Breakpoint value in progressive ratio session0.60.70.70.80.9-0.9
Distance traveled before self-admin0.80.91.30.0-1.11.1
Distance traveled after self-admin2.32.53.5-0.7-1.91.9
Delta time in closed arm before/after self-admin0.20.20.30.0-0.60.6
Delta time in open arm before/after self-admin0.40.40.5-0.10.7-0.7
Diff in mean of infusions in LGA sessions2.32.57.22.70.5-0.5
Extinction: sum of active levers before priming0.70.71.71.30.4-0.4
Active lever presses in extinction session 60.00.00.0-0.10.0-0.0
Delta distance traveled before/after self-admin0.60.70.7-0.8-0.80.8
Delta ambulatory time before/after self-admin0.10.10.3-0.6-0.00.0
Time in closed arm before self-admin0.00.00.0-0.1-0.20.2
Time in closed arm after self-admin0.40.50.60.4-0.80.8
Time in open arm before self-admin0.90.92.71.7-0.10.1
Time in open arm after self-admin0.50.60.60.80.8-0.8
Sum of active levers in priming session hrs 5-61.21.23.11.80.5-0.5
Time to tail flick, vehicle, before self-admin2.32.32.4-1.41.6-1.6
Time to tail flick, vehicle, after self-admin0.30.30.5-0.7-0.40.4
Time to tail flick, test, before self-admin3.93.84.2-1.7-2.12.1
Time to tail flick, test, after self-admin0.91.02.1-1.40.6-0.6
Delta time to tail flick, vehicle, before/after SA0.30.30.50.2-0.70.7
Delta time to tail flick, test, before/after SA2.92.63.7-0.81.9-1.9
Ambulatory time before self-admin0.50.50.7-0.5-0.80.8
Ambulatory time after self-admin1.92.12.9-0.7-1.71.7
Total heroin consumption0.91.11.6-0.31.3-1.3
Area under the delay curve0.10.20.2-0.40.4-0.4
Delay disc. indifference point, 0s delay0.10.10.3-0.5-0.00.0
Delay disc. indifference point, 16s delay0.10.10.20.5-0.10.1
Delay disc. indifference point, 2s delay0.10.10.20.4-0.10.1
Delay disc. indifference point, 24s delay0.70.71.00.21.0-1.0
Delay disc. indifference point, 4s delay0.20.20.60.7-0.10.1
Delay disc. indifference point, 8s delay1.81.83.9-2.00.9-0.9
Delay discount exponential model param0.10.10.10.4-0.40.4
Delay discount hyperbolic model param0.10.10.10.2-0.30.3
Fecal boli incidents, locomotor time 10.90.91.3-1.10.9-0.9
Change in fecal boli incidents, locomotor task1.31.23.01.7-0.60.6
Time >=10cm from walls, locomotor time 11.01.02.51.60.5-0.5
Bouts of movement, locomotor time 10.60.70.9-0.41.0-1.0
Total resting periods, locomotor time 10.30.40.4-0.50.6-0.6
Rest time, locomotor task time 10.91.01.0-1.0-1.01.0
Distance moved, locomotor task time 10.40.40.50.50.7-0.7
Vertical activity count, locomotor time 10.30.31.01.0-0.20.2
Time >=10cm from walls, locomotor time 22.02.23.10.51.8-1.8
Bouts of movement, locomotor time 21.41.53.31.8-0.80.8
Total resting periods, locomotor time 21.11.22.01.4-0.90.9
Rest time, locomotor task time 20.30.40.5-0.5-0.70.7
Distance moved, locomotor task time 20.80.91.3-0.11.2-1.2
Vertical activity count, locomotor time 20.40.40.6-0.30.8-0.8
Weight adjusted by age3.13.59.9-3.10.5-0.5
Seeking ratio, delayed vs. immediate footshock0.50.50.70.4-0.90.9
Locomotion in novel chamber1.72.13.1-0.4-1.81.8
Locomotion in novel chamber post-restriction2.12.53.8-0.1-2.02.0
Progressive ratio0.20.30.80.9-0.10.1
Food seeking constrained by brief footshock1.31.51.91.41.2-1.2
Seeking ratio, punishment vs. effort0.10.10.2-0.10.4-0.4
Run reversals in cocaine runway, females0.60.61.7-1.3-0.40.4
Run reversals in cocaine runway, males1.21.23.61.90.0-0.0
Latency to leave start box in cocaine runway0.70.81.31.1-0.70.7
Latency to leave start box in cocaine runway, F0.91.01.61.3-0.80.8
Latency to leave start box in cocaine runway, M0.10.10.2-0.4-0.20.2
Cd content in liver1.01.13.31.8-0.20.2
Co content in liver0.40.40.6-0.1-0.80.8
Cu content in liver0.30.30.4-0.6-0.50.5
Fe content in liver0.00.00.00.0-0.10.1
K content in liver0.20.20.60.8-0.20.2
Mg content in liver0.40.40.40.60.6-0.6
Mn content in liver0.50.61.31.2-0.50.5
Na content in liver0.80.81.11.00.8-0.8
Rb content in liver1.11.43.41.80.6-0.6
Se content in liver0.10.10.20.5-0.10.1
Sr content in liver3.02.73.41.2-1.81.8
Zn content in liver2.42.63.11.3-1.81.8