Hub : Genes

Ccdc12

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression ENSRNOG00000020946 0.12 0.11 2.4e-05 0.08 0.08 0.07 0.08 7.0e-05 3.0e-05 8.7e-05 3.4e-05
2 Brain gene expression ENSRNOG00000020946 0.05 0.04 3.0e-04 0.02 0.02 0.02 0.01 8.1e-03 1.1e-02 8.1e-03 2.1e-02
3 Brain intron excision ratio chr8:110635863:110668604 0.04 0.04 3.0e-04 0.03 0.03 0.03 0.03 9.2e-04 5.2e-04 4.7e-04 9.9e-04
4 Brain intron excision ratio chr8:110668671:110683304 0.05 0.04 4.1e-05 0.04 0.04 0.04 0.04 2.5e-04 6.2e-05 4.7e-05 9.8e-05
5 Brain mRNA stability ENSRNOG00000020946 0.19 0.13 1.7e-15 0.18 0.18 0.18 0.18 1.3e-16 3.6e-16 2.6e-16 2.2e-16
6 Eye gene expression ENSRNOG00000020946 0.31 0.22 2.6e-03 0.1 0.16 0.15 0.12 1.4e-02 1.7e-03 3.0e-03 6.2e-03
7 IL gene expression ENSRNOG00000020946 0.15 0.13 6.9e-03 0.06 0.04 0.06 0.04 1.4e-02 5.1e-02 1.3e-02 4.8e-02
8 LHb gene expression ENSRNOG00000020946 0.62 0.23 2.0e-07 0.22 0.2 0.19 0.22 4.7e-06 1.9e-05 2.4e-05 7.6e-06
9 Liver mRNA stability ENSRNOG00000020946 0.02 0.02 1.9e-03 0.01 0.02 0.01 0.01 1.4e-02 2.3e-03 2.5e-02 1.3e-02
10 NAcc gene expression ENSRNOG00000020946 0.1 0.09 1.7e-06 0.06 0.08 0.08 0.08 2.6e-05 1.9e-06 1.6e-06 2.2e-06
11 NAcc intron excision ratio chr8:110635863:110668604 0.04 0.04 4.9e-03 0.01 0.03 0.01 0.01 7.0e-02 5.3e-03 9.9e-02 6.0e-02
12 NAcc intron excision ratio chr8:110668671:110683304 0.04 0.04 3.8e-03 0.01 0.03 0.01 0.01 3.2e-02 5.0e-03 3.9e-02 4.7e-02
13 PL gene expression ENSRNOG00000020946 0.08 0.11 2.1e-04 0.04 0.03 0.03 0.04 8.8e-04 3.4e-03 1.4e-03 1.1e-03
14 PL mRNA stability ENSRNOG00000020946 0.06 0.06 1.4e-04 0.04 0.04 0.04 0.04 8.8e-04 3.2e-04 7.0e-04 7.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
BMI with tail0.51.62.8-1.1-1.41.0-1.01.4-1.11.5-1.5-1.2-1.71.2-1.1-1.41.1
BMI without tail1.94.05.2-1.9-2.11.8-1.92.0-1.91.8-2.0-2.0-2.22.0-2.0-2.32.0
Body weight7.029.632.1-5.4-5.55.3-5.35.6-5.45.2-5.4-5.4-5.65.4-5.4-5.75.4
Epididymis fat weight0.30.61.2-0.8-0.60.5-0.60.6-0.80.9-0.9-0.8-0.80.8-0.8-1.10.8
Glucose0.30.51.0-0.6-0.70.6-0.60.7-0.61.0-0.8-0.6-0.60.6-0.6-0.70.6
Heart weight2.63.74.3-1.9-2.02.0-2.02.1-1.91.9-1.9-1.9-1.71.9-1.9-1.91.9
Left kidney weight0.82.44.9-1.3-1.71.4-1.31.7-1.42.2-1.9-1.4-1.41.4-1.4-1.71.4
Right kidney weight0.20.61.5-0.6-0.80.6-0.50.8-0.61.2-0.9-0.6-0.70.7-0.6-1.00.7
Tail length7.021.022.3-4.7-4.64.6-4.64.5-4.74.2-4.5-4.7-4.54.7-4.7-4.74.7
Length with tail9.836.037.0-6.1-6.06.0-6.16.0-6.15.7-5.9-6.1-5.86.1-6.1-6.16.1
Length without tail6.714.715.4-3.8-3.83.8-3.83.9-3.83.9-3.8-3.8-3.83.8-3.8-3.73.8
Liver weight, left0.00.00.1-0.2-0.10.2-0.20.1-0.20.1-0.2-0.2-0.00.2-0.2-0.20.2
Liver weight, right1.32.12.6-1.4-1.51.4-1.41.4-1.41.4-1.6-1.4-1.41.4-1.4-1.61.5
Parametrial fat weight1.22.33.1-1.5-1.61.5-1.51.5-1.51.7-1.7-1.5-1.31.5-1.5-1.51.5
Retroperitoneal fat weight0.62.12.6-1.4-1.51.4-1.41.5-1.41.5-1.6-1.4-1.11.4-1.4-1.61.4
Intraocular pressure0.91.31.6-1.3-1.01.2-1.21.0-1.21.1-1.0-1.2-1.01.2-1.2-1.01.2
Extensor digitorum longus weight0.10.60.70.80.8-0.80.8-0.70.8-0.60.80.80.7-0.80.80.7-0.8
Soleus weight4.212.213.6-3.4-3.63.5-3.53.7-3.43.5-3.5-3.4-3.63.5-3.4-3.53.4
Tibialis anterior weight0.00.00.1-0.1-0.20.1-0.10.3-0.20.4-0.1-0.2-0.20.2-0.2-0.40.2
Tibia length7.420.822.7-4.4-4.74.5-4.54.8-4.44.6-4.6-4.5-4.84.5-4.5-4.74.5
Number of licking bursts0.20.20.40.40.5-0.40.4-0.40.4-0.60.60.40.4-0.40.40.5-0.4
Food consumed during 24 hour testing period1.61.92.1-1.3-1.41.4-1.41.4-1.31.5-1.4-1.3-1.41.3-1.3-1.31.3
Times rat made contact with spout0.40.51.0-0.7-0.50.6-0.60.5-0.71.0-0.9-0.7-0.60.7-0.7-0.60.7
Mean time between licks in bursts1.11.52.01.31.1-1.11.1-1.11.3-1.41.31.21.1-1.31.31.3-1.3
Mean num. licks in bursts0.60.81.5-0.8-0.80.8-0.80.7-0.81.2-1.2-0.8-0.80.8-0.8-0.80.9
Std. dev. time between licks in bursts3.94.77.12.22.0-2.02.0-1.92.2-2.72.52.11.9-2.22.22.3-2.2
Water consumed over 24 hours0.00.00.00.10.1-0.10.1-0.00.10.1-0.10.10.0-0.10.10.1-0.1
Indifference point 0 sec1.11.82.1-1.3-1.31.4-1.41.4-1.31.4-1.2-1.3-1.31.3-1.3-1.21.3
Indifference point AUC0.10.10.2-0.3-0.30.2-0.20.1-0.30.3-0.3-0.3-0.30.3-0.3-0.50.3
Indifference point function ln k0.10.10.30.50.2-0.30.3-0.10.5-0.30.20.40.2-0.40.40.5-0.4
Indifference point function log k0.10.10.30.50.2-0.30.3-0.10.5-0.30.20.40.2-0.40.40.5-0.4
Delay discounting total patch changes 0 sec1.32.12.5-1.4-1.41.6-1.61.5-1.41.6-1.3-1.4-1.41.4-1.4-1.31.4
Delay discounting total patch changes 12 sec0.91.21.5-1.1-1.21.2-1.21.1-1.11.1-1.0-1.1-0.81.1-1.1-1.11.1
Delay discounting total patch changes 18 sec2.43.13.9-1.9-1.61.7-1.81.6-1.91.7-1.6-1.9-2.01.8-1.9-1.61.8
Delay discounting total patch changes 24 sec3.14.04.3-2.0-2.12.1-2.12.0-2.02.0-1.8-2.0-2.02.0-2.0-2.02.0
Delay discounting total patch changes 6 sec0.10.20.4-0.4-0.40.5-0.50.4-0.40.6-0.4-0.4-0.30.4-0.4-0.40.4
Delay discounting time to switch 0 sec0.10.20.40.50.5-0.50.5-0.40.5-0.40.50.50.6-0.50.50.4-0.5
Delay discounting water rate 0 sec0.20.30.6-0.5-0.50.6-0.60.5-0.50.5-0.5-0.5-0.80.5-0.5-0.10.5
Delay discounting water rate 12 sec0.40.50.7-0.7-0.90.8-0.90.8-0.70.6-0.6-0.7-0.80.7-0.7-0.70.7
Delay discounting water rate 18 sec0.00.10.2-0.1-0.50.3-0.30.4-0.10.0-0.2-0.1-0.30.2-0.1-0.10.1
Delay discounting water rate 24 sec0.70.91.2-1.0-1.00.9-0.90.9-1.00.9-1.1-1.0-0.91.0-1.0-0.91.0
Delay discounting water rate 6 sec0.40.61.0-0.7-1.00.9-0.90.9-0.70.7-0.8-0.7-1.00.7-0.7-0.60.7
Locomotor activity6.09.610.0-3.1-3.23.1-3.23.2-3.12.9-2.9-3.2-3.13.1-3.1-2.93.1
Locomotor testing distance5.89.710.4-3.1-3.23.2-3.23.2-3.12.7-2.8-3.2-3.23.2-3.1-3.03.1
Locomotor testing rearing0.20.40.5-0.7-0.60.7-0.70.6-0.7-0.2-0.1-0.7-0.70.6-0.6-0.40.6
Light reinforcement 10.71.31.9-1.1-1.31.2-1.21.1-1.11.1-1.1-1.1-0.91.1-1.1-1.41.1
Light reinforcement 20.10.10.20.3-0.1-0.10.2-0.10.3-0.20.20.30.5-0.30.3-0.1-0.3
Reaction time number correct0.30.40.50.60.7-0.60.6-0.60.6-0.40.60.70.7-0.70.70.7-0.7
Reaction time mean minus median0.00.00.1-0.2-0.30.2-0.10.2-0.20.1-0.2-0.2-0.30.2-0.2-0.30.2
Reaction time mean minus median AUC0.20.30.4-0.5-0.60.5-0.50.5-0.50.2-0.4-0.5-0.60.5-0.5-0.60.5
Reaction time num false alarms0.30.41.00.60.6-0.50.5-0.60.6-1.00.80.60.8-0.60.60.6-0.6
Reaction time num false alarms AUC0.10.10.30.20.2-0.20.2-0.30.3-0.50.40.30.6-0.30.30.3-0.3
Reaction time trials correct on left0.30.40.50.60.7-0.60.6-0.60.6-0.40.60.70.7-0.70.70.7-0.7
Reaction time trials on left0.30.50.60.70.7-0.60.6-0.70.7-0.40.70.70.7-0.70.70.8-0.7
Reaction time mean0.00.00.1-0.10.1-0.10.1-0.1-0.1-0.30.0-0.1-0.10.1-0.1-0.10.1
Reaction time mean AUC0.00.00.2-0.00.2-0.20.1-0.2-0.0-0.40.1-0.0-0.00.0-0.00.00.0
Median of all reaction times0.00.00.1-0.10.2-0.10.1-0.1-0.1-0.40.1-0.10.00.1-0.1-0.00.1
Reaction time omissions0.40.50.90.60.9-0.70.7-0.90.6-0.80.60.60.9-0.60.60.8-0.6
Reaction time false alarm rate0.00.10.30.10.1-0.10.1-0.20.1-0.50.30.20.4-0.20.20.1-0.2
Reaction time premature initiation rate1.92.63.2-1.7-1.61.6-1.61.5-1.71.5-1.7-1.7-1.21.7-1.7-1.81.7
Reaction time premature initiations0.91.31.6-1.2-1.21.1-1.11.1-1.21.2-1.2-1.1-0.71.2-1.2-1.31.2
Std. dev. reaction times0.10.10.2-0.4-0.20.2-0.20.2-0.40.1-0.3-0.4-0.40.4-0.4-0.40.4
Reaction time trials completed0.30.50.60.70.7-0.60.6-0.70.7-0.40.70.70.7-0.70.70.8-0.7
Reaction time trials AUC0.40.60.70.80.8-0.70.7-0.80.8-0.60.80.80.8-0.80.80.9-0.8
Social response proportion0.40.50.7-0.7-0.70.7-0.70.6-0.70.8-0.8-0.7-0.40.7-0.7-0.70.7
Social responses0.40.50.7-0.7-0.80.8-0.80.7-0.70.4-0.7-0.7-0.50.7-0.7-0.70.7
Social time0.50.61.30.80.7-0.70.8-0.70.8-0.80.60.81.1-0.80.80.7-0.8
Conditioned locomotion3.23.84.11.92.0-1.92.0-2.01.9-1.81.91.92.0-1.91.91.9-1.9
Cocaine response after cond. corrected0.20.20.3-0.5-0.50.5-0.50.4-0.50.2-0.4-0.5-0.50.5-0.5-0.50.5
Cocaine response after cond. not corrected1.71.92.1-1.4-1.41.4-1.41.3-1.41.2-1.4-1.4-1.41.4-1.4-1.41.4
Cocaine response before conditioning1.31.61.9-1.2-1.31.2-1.21.4-1.21.4-1.4-1.2-1.41.2-1.2-1.21.2
Saline control response1.41.82.0-1.4-1.41.4-1.41.2-1.41.4-1.4-1.4-1.31.4-1.4-1.21.4
Condit. Reinf. active minus inactive responses2.42.93.4-1.7-1.81.7-1.71.8-1.71.7-1.7-1.7-1.81.7-1.7-1.71.7
Condit. Reinf. active-inactive response ratio1.91.92.3-1.3-1.51.4-1.41.5-1.31.4-1.4-1.4-1.41.4-1.4-1.51.4
Condit. Reinf. active responses1.92.73.3-1.6-1.61.6-1.61.7-1.61.8-1.7-1.6-1.61.6-1.6-1.61.6
Condit. Reinf. inactive responses0.00.00.10.10.2-0.10.1-0.20.10.10.10.10.1-0.10.10.3-0.1
Condit. Reinf. lever presses2.73.84.5-1.8-2.01.9-1.92.0-1.92.1-1.9-1.9-2.01.9-1.9-2.01.9
Condit. Reinf. lever reinforcers received2.23.03.4-1.7-1.71.7-1.81.8-1.71.8-1.7-1.7-1.81.7-1.7-1.71.7
Pavlov. Cond. lever latency0.50.70.90.80.9-0.90.9-1.00.8-0.50.70.81.0-0.80.80.8-0.8
Pavlov. Cond. magazine entry latency0.10.10.20.40.1-0.30.3-0.10.3-0.50.30.30.1-0.30.30.3-0.3
Pavlov. Cond. change in total contacts2.63.74.3-1.9-2.12.0-2.02.1-1.91.6-1.8-1.9-2.11.9-1.9-1.81.9
Pavlov. Cond. index score0.10.10.3-0.3-0.50.4-0.40.5-0.30.2-0.3-0.3-0.60.3-0.3-0.40.3
Pavlov. Cond. latency score0.10.10.2-0.2-0.50.3-0.30.5-0.20.1-0.3-0.3-0.50.3-0.3-0.30.3
Pavlov. Cond. lever contacts1.11.51.9-1.2-1.41.3-1.31.4-1.21.0-1.2-1.2-1.31.2-1.2-1.21.2
Pavlov. Cond. magazine entry number0.30.30.5-0.6-0.50.5-0.50.4-0.60.7-0.6-0.6-0.40.6-0.6-0.70.6
Pavlov. Cond. intertrial magazine entries0.40.60.90.60.9-0.70.6-0.80.7-0.80.90.70.8-0.70.70.9-0.7
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.2-0.50.4-0.40.5-0.30.1-0.3-0.3-0.50.3-0.3-0.30.3
Pavlov. Cond. response bias0.10.10.3-0.3-0.50.4-0.40.6-0.30.1-0.3-0.3-0.50.3-0.3-0.30.3
Conditioned reinforcement - actives0.30.30.60.50.8-0.70.7-0.70.5-0.40.60.5-0.0-0.50.50.7-0.5
Conditioned reinforcement - inactives0.91.12.01.01.0-1.01.0-1.01.0-1.41.01.00.8-1.01.01.1-1.0
Conditioned locomotion0.40.40.70.70.8-0.80.8-0.80.7-0.00.50.60.3-0.60.60.8-0.7
Intermittent access intake day 1-15 change0.60.60.90.70.8-0.80.8-0.80.7-0.81.00.70.5-0.70.70.7-0.7
Intermittent access intake escalation0.40.40.70.60.7-0.70.7-0.70.6-0.80.80.60.4-0.60.60.6-0.6
Intermittent access intake escalation 20.00.00.1-0.2-0.10.1-0.10.1-0.20.1-0.0-0.2-0.40.2-0.2-0.20.2
Intermitt. access day 1 inactive lever presses0.00.00.00.10.0-0.00.0-0.00.10.1-0.00.00.0-0.00.00.2-0.0
Intermitt. access day 15 inactive lever presses0.70.81.40.90.8-0.80.8-0.80.9-1.21.00.90.9-0.90.90.9-0.9
Intermitt. access escalation Index0.00.00.0-0.0-0.00.0-0.00.0-0.0-0.20.0-0.0-0.00.0-0.00.00.0
Intermittent access day 1 total infusions0.00.00.10.10.2-0.20.1-0.20.1-0.20.10.1-0.0-0.10.10.3-0.1
Intermittent access day 15 total infusions0.30.30.50.50.7-0.70.6-0.70.5-0.70.70.50.2-0.50.50.6-0.6
Intermittent access terminal intake (last 3 days)0.10.10.20.30.5-0.50.4-0.50.3-0.50.50.3-0.0-0.30.30.5-0.3
Intermittent access total infusions0.50.50.80.70.8-0.80.7-0.80.7-0.70.70.70.3-0.70.70.9-0.7
Intermittent access day 1 locomotion0.10.10.20.30.4-0.40.3-0.30.3-0.30.20.30.3-0.30.30.5-0.3
Intermittent access day 15 total locomotion0.60.60.90.70.8-0.80.8-0.80.7-1.00.90.70.6-0.70.70.8-0.8
Intermittent access total locomotion1.21.31.61.11.3-1.31.2-1.21.1-0.81.01.10.9-1.11.11.3-1.1
Intermittent access standard deviation0.20.20.4-0.5-0.40.4-0.40.4-0.50.3-0.3-0.5-0.60.5-0.5-0.40.5
Cocaine induced anxiety0.50.60.70.80.8-0.80.8-0.80.8-0.80.60.80.7-0.80.80.8-0.8
Post-drug Anxiety0.20.20.40.50.4-0.40.4-0.40.5-0.50.40.50.7-0.50.50.4-0.5
Baseline Anxiety0.20.20.70.40.3-0.30.3-0.30.4-0.90.70.40.5-0.40.40.3-0.4
Lifetime Intake0.30.40.60.60.7-0.70.6-0.70.6-0.50.60.60.3-0.60.60.8-0.6
Incentive Sensitization - Responses2.02.02.91.41.4-1.41.4-1.41.4-1.71.51.41.4-1.41.41.3-1.4
Incentive Sensitization - Breakpoint1.91.92.91.31.4-1.41.3-1.41.3-1.71.51.31.4-1.31.31.3-1.3
Progressive ratio test 1 active lever presses0.00.00.10.00.2-0.20.1-0.20.0-0.1-0.00.0-0.3-0.00.00.2-0.1
Progressive ratio test 1 breakpoint0.00.00.10.20.3-0.30.2-0.20.2-0.20.10.1-0.2-0.20.20.3-0.2
Progressive ratio test 1 inactive lever presses0.40.40.60.60.7-0.70.7-0.70.6-0.70.70.60.4-0.60.60.7-0.7
Progressive ratio test 2 active lever presses1.01.01.31.01.1-1.11.1-1.11.0-1.01.01.00.7-1.01.01.1-1.0
Progressive ratio test 2 breakpoint0.80.91.10.91.0-1.11.0-1.00.9-1.01.00.90.7-0.90.91.0-0.9
Progressive ratio test 2 inactive lever presses2.12.43.11.61.6-1.61.6-1.61.5-1.41.51.51.1-1.51.51.8-1.6
Total sessions with >9 infusions0.10.10.10.20.3-0.40.3-0.30.2-0.30.40.20.2-0.20.20.2-0.2
Short access day 1 total inactive lever presses3.74.15.12.02.0-2.02.0-2.02.0-2.32.32.01.6-2.02.02.1-2.0
Short access day 10 total inactive lever presses0.00.00.00.1-0.00.0-0.00.00.1-0.20.20.10.2-0.10.10.1-0.1
Short access day 1 total infusions0.91.01.11.01.0-1.01.0-1.01.0-1.11.11.00.9-1.01.01.0-1.0
Short access day 10 total infusions0.00.10.20.20.3-0.30.3-0.30.20.10.10.2-0.1-0.20.20.4-0.2
Short access total infusions0.50.50.70.70.8-0.80.8-0.80.7-0.60.70.70.5-0.70.70.8-0.7
Short access day 1 locomotion0.00.10.10.20.3-0.30.3-0.30.20.20.20.20.1-0.20.20.3-0.2
Short access day 10 total locomotion0.10.10.5-0.2-0.10.1-0.10.1-0.20.7-0.4-0.2-0.30.2-0.2-0.10.2
Short access total locomotion0.00.00.30.10.2-0.20.1-0.20.10.6-0.10.1-0.0-0.10.10.2-0.1
Compulsive drug intake0.00.00.20.1-0.00.00.00.00.1-0.40.20.10.2-0.10.1-0.0-0.1
One hour access (0.3 mA shock)0.10.20.40.30.5-0.50.4-0.50.3-0.60.60.30.0-0.30.30.4-0.3
One hour access (shock baseline)0.10.10.10.20.4-0.40.3-0.40.2-0.30.30.2-0.2-0.20.20.4-0.2
Number of responses in last shaping day0.80.81.10.90.9-0.90.9-0.90.9-1.01.00.90.7-0.90.90.9-0.9
Context. condit. distance diff. score0.00.00.0-0.0-0.10.0-0.00.0-0.0-0.10.0-0.0-0.10.0-0.0-0.10.0
Locomotion velocity, session 10.00.00.10.30.2-0.20.2-0.10.3-0.10.20.20.1-0.20.20.3-0.2
Locomotion distance, session 11.01.31.8-1.0-1.21.1-1.01.3-1.01.3-1.2-1.1-1.31.1-1.1-1.21.1
Locomotion velocity, session 20.20.20.30.60.4-0.50.5-0.40.6-0.50.50.50.4-0.50.50.5-0.5
Locomotion distance, session 20.00.00.10.1-0.1-0.10.10.20.1-0.00.00.1-0.3-0.10.10.0-0.1
Locomotion velocity, session 30.10.10.3-0.3-0.50.3-0.20.4-0.30.3-0.5-0.3-0.50.3-0.3-0.50.3
Locomotion distance, session 30.90.91.21.00.8-1.01.0-0.81.0-1.10.91.00.8-1.01.00.9-1.0
Stereotopy head waving bouts, day 30.00.00.0-0.2-0.10.2-0.20.1-0.20.1-0.1-0.2-0.20.2-0.2-0.10.2
Stereotopy head waving duration, day 30.20.30.4-0.6-0.50.6-0.60.5-0.60.3-0.4-0.6-0.50.6-0.6-0.40.6
Locomotion velocity, session 70.30.30.4-0.6-0.70.7-0.70.6-0.6-0.2-0.2-0.6-0.60.6-0.6-0.60.5
Locomotion distance, session 70.60.82.20.80.7-0.80.8-0.70.8-1.51.10.80.7-0.80.80.8-0.9
Stereotopy head waving bouts, day 70.10.10.20.30.3-0.30.4-0.40.30.10.10.30.4-0.30.30.2-0.3
Stereotopy head waving duration, day 70.20.30.7-0.5-0.40.4-0.40.4-0.50.8-0.7-0.5-0.40.5-0.5-0.60.5
Locomotion velocity, session 80.30.30.7-0.5-0.70.5-0.50.8-0.50.5-0.6-0.5-0.90.5-0.5-0.70.5
Locomotion distance, session 80.30.40.8-0.5-0.80.6-0.60.9-0.50.5-0.6-0.6-0.90.6-0.6-0.70.6
Degree of sensitization distance1.21.21.6-1.2-1.11.2-1.21.1-1.20.9-0.9-1.2-1.01.1-1.2-1.01.1
Degree of sensitization stereotypy0.00.00.2-0.00.1-0.10.1-0.1-0.00.5-0.3-0.00.20.0-0.0-0.20.1
Condit. Reinf. active minus inactive responses0.10.10.1-0.3-0.30.3-0.40.2-0.30.2-0.2-0.3-0.20.3-0.3-0.20.3
Condit. Reinf. active-inactive response ratio0.20.20.3-0.5-0.50.6-0.60.4-0.50.5-0.4-0.5-0.40.5-0.5-0.40.5
Condit. Reinf. active responses0.00.00.10.10.2-0.20.2-0.30.1-0.30.20.20.2-0.20.10.1-0.1
Condit. Reinf. inactive responses0.70.81.10.90.9-1.01.0-1.00.9-0.90.80.90.8-0.90.90.7-0.9
Incentive salience index mean0.00.10.10.20.2-0.20.2-0.30.2-0.20.20.20.2-0.20.20.3-0.2
Condit. Reinf. lever presses1.41.92.11.51.4-1.41.4-1.31.5-1.21.31.41.2-1.41.41.4-1.4
Time in familiar zone, hab. session 11.61.52.41.11.3-1.11.1-1.21.1-1.51.41.11.2-1.11.11.3-1.1
Time in novel zone, hab. session 10.70.71.5-0.7-0.80.7-0.70.7-0.71.2-1.0-0.7-0.70.8-0.8-0.90.8
Total zone transitions, hab. session 10.71.01.3-0.9-1.10.9-0.91.1-0.90.9-1.0-0.9-1.10.9-0.9-1.10.9
Total locomotion distance, hab. session 10.30.40.6-0.5-0.70.5-0.50.6-0.60.7-0.7-0.6-0.60.6-0.6-0.70.6
Locomotion velocity, hab. session 10.30.40.6-0.6-0.70.6-0.60.6-0.60.8-0.8-0.6-0.70.6-0.6-0.70.6
Time in familiar zone, hab. session 20.50.61.20.70.7-0.70.6-0.70.7-1.10.90.70.6-0.70.70.8-0.7
Time in novel zone, hab. session 20.00.00.1-0.2-0.20.2-0.20.2-0.20.3-0.2-0.2-0.10.2-0.2-0.10.2
Total zone transitions, hab. session 20.10.10.3-0.2-0.50.3-0.30.6-0.20.3-0.4-0.3-0.50.3-0.3-0.40.3
Total locomotion distance, hab. session 20.30.40.8-0.5-0.70.5-0.50.7-0.50.9-0.8-0.6-0.60.6-0.6-0.70.6
Locomotion velocity, hab. session 20.20.30.6-0.4-0.50.4-0.40.5-0.40.8-0.7-0.4-0.50.5-0.5-0.60.5
Novel to familiar place preference ratio0.90.91.1-0.9-1.01.0-1.01.0-0.90.9-0.9-1.0-0.90.9-0.9-0.90.9
Novelty place preference0.90.91.0-0.9-1.01.0-1.01.0-0.90.9-0.9-0.9-0.90.9-0.9-0.90.9
Time in novel zone, NPP test1.11.21.4-1.1-1.11.2-1.21.1-1.11.0-1.0-1.1-1.01.1-1.1-1.01.1
Total zone transitions, NPP test2.63.75.0-1.7-2.01.8-1.72.1-1.82.1-2.1-1.8-2.21.8-1.8-2.11.8
Total locomotion distance, NPP test1.11.52.4-1.1-1.21.1-1.01.2-1.11.5-1.4-1.2-1.31.2-1.2-1.31.2
Locomotion velocity, NPP test1.21.72.6-1.2-1.31.1-1.11.3-1.21.6-1.5-1.2-1.31.2-1.2-1.41.2
Pavlov. Cond. lever latency5.16.57.1-2.7-2.52.7-2.72.5-2.72.1-2.4-2.6-2.32.6-2.6-2.62.6
Pavlov. Cond. magazine entry latency6.68.58.93.02.9-2.92.9-2.83.0-2.82.93.02.7-3.03.03.0-3.0
Pavlov. Cond. change in total contacts1.81.92.41.41.4-1.31.4-1.41.4-1.21.41.41.3-1.41.41.5-1.4
Pavlov. Cond. index score6.58.38.93.02.9-2.92.9-2.83.0-2.62.82.92.7-2.92.93.0-2.9
Pavlov. Cond. latency score6.38.08.62.92.8-2.92.9-2.82.9-2.52.82.92.6-2.92.92.9-2.9
Pavlov. Cond. lever contacts2.93.53.92.01.9-2.02.0-1.82.0-1.31.71.91.7-1.91.91.9-1.9
Pavlov. Cond. magazine entry number7.79.610.4-3.1-3.13.1-3.13.0-3.12.9-3.1-3.1-2.93.1-3.1-3.23.1
Pavlov. Cond. intertrial magazine entries0.40.50.5-0.7-0.70.7-0.70.7-0.70.3-0.5-0.7-0.70.7-0.7-0.70.7
Pavlov. Cond. lever-magazine prob. diff.5.87.27.92.82.7-2.72.7-2.62.8-2.42.72.72.5-2.72.72.8-2.8
Pavlov. Cond. response bias7.18.79.33.03.0-3.03.0-2.93.0-2.72.93.02.8-3.03.03.0-3.0
Bone: apparent density0.00.00.1-0.2-0.20.2-0.20.2-0.20.1-0.2-0.2-0.20.2-0.2-0.20.2
Bone surface0.00.10.10.30.1-0.20.2-0.10.3-0.40.20.30.1-0.20.30.1-0.2
Bone volume0.00.00.00.1-0.0-0.10.10.00.1-0.10.00.1-0.0-0.10.1-0.0-0.1
Bone: connectivity density0.20.30.40.50.6-0.60.6-0.70.5-0.50.50.60.6-0.60.60.6-0.6
Bone: cortical apparent density0.30.40.50.60.7-0.70.7-0.70.6-0.60.50.60.7-0.60.60.6-0.6
Bone: cortical area0.10.20.60.40.4-0.40.4-0.30.4-0.70.50.40.4-0.40.40.4-0.4
Bone: cortical porosity0.10.10.10.20.3-0.20.2-0.30.2-0.20.30.20.3-0.20.20.2-0.2
Bone: cortical porosity0.20.20.30.40.6-0.40.4-0.50.4-0.50.60.40.5-0.40.40.5-0.4
Bone: cortical thickness0.10.10.2-0.4-0.40.4-0.40.4-0.40.1-0.3-0.4-0.40.4-0.4-0.40.4
Bone: cortical thickness0.00.00.0-0.1-0.10.1-0.10.1-0.1-0.0-0.0-0.1-0.10.1-0.1-0.10.1
Bone: cortical tissue density0.30.40.50.60.7-0.70.7-0.70.6-0.60.50.60.7-0.60.60.6-0.6
Bone: elastic displacement0.00.10.2-0.2-0.20.2-0.20.2-0.20.4-0.2-0.2-0.20.2-0.2-0.20.2
Bone: elastic work0.60.71.0-0.8-0.90.8-0.81.0-0.80.7-0.8-0.8-1.00.8-0.8-0.90.8
Bone: endosteal estimation0.10.20.3-0.4-0.40.5-0.50.5-0.4-0.2-0.1-0.4-0.40.4-0.4-0.30.4
Bone: endosteal perimeter1.12.42.61.61.5-1.51.5-1.41.6-1.61.61.61.5-1.61.61.6-1.6
Bone: final force0.81.41.5-1.2-1.21.2-1.21.2-1.21.0-1.1-1.2-1.21.2-1.2-1.21.2
Bone: final moment1.11.82.1-1.3-1.41.4-1.41.4-1.31.1-1.3-1.3-1.41.3-1.3-1.41.3
Bone: marrow area0.10.20.3-0.5-0.50.5-0.60.5-0.5-0.2-0.1-0.5-0.50.5-0.5-0.40.5
Bone: maximum diameter0.40.70.90.90.8-0.80.8-0.80.9-0.80.90.90.8-0.90.91.0-0.9
Bone: maximum force0.71.21.4-1.1-1.11.2-1.21.2-1.10.8-1.0-1.1-1.11.1-1.1-1.11.1
Bone: maximum moment0.81.41.6-1.2-1.21.3-1.31.3-1.20.8-1.1-1.2-1.21.2-1.2-1.21.2
Bone: minimum diameter0.30.61.50.80.7-0.70.7-0.60.8-1.21.00.80.7-0.80.80.8-0.8
Bone: periosteal estimation0.00.00.2-0.1-0.20.2-0.20.2-0.1-0.40.1-0.2-0.20.1-0.1-0.10.1
Bone: periosteal perimeter1.22.02.51.41.4-1.31.3-1.31.4-1.61.51.41.4-1.41.41.5-1.4
Bone: post-yield work0.00.00.1-0.2-0.30.3-0.30.3-0.2-0.0-0.1-0.2-0.20.2-0.2-0.20.2
Bone: stiffness0.10.20.2-0.5-0.40.5-0.50.4-0.50.1-0.3-0.5-0.40.4-0.5-0.50.5
Bone: tissue strength3.13.03.3-1.8-1.81.8-1.81.8-1.81.4-1.6-1.8-1.81.8-1.8-1.71.8
Bone: trabecular number0.50.80.90.90.9-0.91.0-0.90.9-1.00.90.90.8-0.90.90.9-0.9
Bone: trabecular spacing1.31.71.9-1.3-1.31.3-1.31.3-1.31.0-1.2-1.3-1.21.3-1.3-1.41.3
Bone: trabecular thickness0.00.10.2-0.1-0.20.1-0.10.2-0.10.5-0.3-0.1-0.20.2-0.1-0.30.2
Bone: trabecular tissue density0.20.30.4-0.6-0.60.6-0.60.6-0.60.4-0.6-0.6-0.50.6-0.6-0.60.6
Breakpoint value in progressive ratio session0.10.10.1-0.3-0.10.2-0.20.1-0.30.3-0.3-0.3-0.30.3-0.3-0.30.3
Distance traveled before self-admin0.00.00.2-0.1-0.20.2-0.20.3-0.1-0.20.1-0.1-0.40.1-0.1-0.10.1
Distance traveled after self-admin0.20.20.50.40.2-0.10.2-0.10.5-0.70.60.50.4-0.50.50.4-0.5
Delta time in closed arm before/after self-admin0.10.10.10.40.4-0.40.4-0.40.4-0.40.40.40.3-0.40.40.4-0.4
Delta time in open arm before/after self-admin0.30.30.4-0.5-0.60.6-0.60.6-0.50.2-0.4-0.5-0.40.5-0.5-0.60.5
Diff in mean of infusions in LGA sessions0.00.00.10.10.2-0.20.2-0.30.1-0.00.10.10.2-0.10.10.1-0.1
Extinction: sum of active levers before priming0.00.00.2-0.10.00.0-0.10.0-0.1-0.20.0-0.1-0.40.1-0.1-0.20.1
Active lever presses in extinction session 60.30.30.8-0.6-0.40.5-0.50.4-0.60.5-0.6-0.6-0.90.5-0.5-0.60.5
Delta distance traveled before/after self-admin0.20.20.50.40.3-0.30.3-0.20.4-0.20.30.40.7-0.40.40.4-0.4
Delta ambulatory time before/after self-admin0.30.30.5-0.5-0.60.7-0.60.7-0.50.2-0.4-0.5-0.10.5-0.5-0.50.5
Time in closed arm before self-admin1.72.03.1-1.4-1.31.3-1.31.3-1.41.4-1.3-1.4-1.81.4-1.4-1.41.4
Time in closed arm after self-admin0.00.00.1-0.1-0.10.1-0.10.1-0.10.3-0.2-0.1-0.40.1-0.1-0.10.1
Time in open arm before self-admin1.31.41.81.21.2-1.31.2-1.31.2-0.91.01.21.4-1.21.21.2-1.2
Time in open arm after self-admin0.20.20.30.40.4-0.50.5-0.40.4-0.60.50.40.5-0.40.40.4-0.4
Sum of active levers in priming session hrs 5-60.50.51.5-0.7-0.50.6-0.60.5-0.71.2-1.0-0.7-0.70.7-0.7-0.70.7
Time to tail flick, vehicle, before self-admin2.12.12.6-1.4-1.41.4-1.41.3-1.41.6-1.5-1.4-1.61.4-1.4-1.41.4
Time to tail flick, vehicle, after self-admin0.60.71.2-0.8-0.90.9-0.90.8-0.71.1-1.0-0.7-0.50.8-0.8-0.70.8
Time to tail flick, test, before self-admin0.10.10.3-0.1-0.30.2-0.20.1-0.10.5-0.5-0.10.30.2-0.1-0.20.2
Time to tail flick, test, after self-admin0.20.20.30.40.5-0.50.5-0.50.40.10.20.40.2-0.40.40.5-0.4
Delta time to tail flick, vehicle, before/after SA0.50.50.90.70.6-0.60.6-0.50.7-0.70.70.70.9-0.70.70.7-0.7
Delta time to tail flick, test, before/after SA0.30.30.50.50.7-0.60.6-0.60.5-0.50.60.50.0-0.50.50.6-0.5
Ambulatory time before self-admin0.10.10.30.20.2-0.10.2-0.10.2-0.50.40.2-0.2-0.20.20.2-0.2
Ambulatory time after self-admin0.00.00.30.1-0.10.1-0.10.20.1-0.50.30.10.1-0.10.10.0-0.1
Total heroin consumption1.21.41.5-1.2-1.21.2-1.21.2-1.21.0-1.2-1.2-1.11.2-1.2-1.21.2
Area under the delay curve2.32.42.51.61.6-1.61.6-1.51.6-1.51.51.61.5-1.61.61.5-1.6
Delay disc. indifference point, 0s delay0.00.00.10.20.1-0.20.2-0.20.2-0.20.20.2-0.0-0.20.20.2-0.2
Delay disc. indifference point, 16s delay1.11.11.51.11.0-1.01.0-1.01.1-1.11.01.11.1-1.11.11.2-1.0
Delay disc. indifference point, 2s delay0.30.30.40.60.6-0.70.7-0.70.6-0.50.60.60.5-0.60.60.4-0.6
Delay disc. indifference point, 24s delay0.90.91.00.91.0-0.90.9-0.90.9-0.80.90.91.0-0.90.90.9-0.9
Delay disc. indifference point, 4s delay2.32.42.61.61.6-1.61.6-1.61.6-1.51.61.61.5-1.61.61.5-1.6
Delay disc. indifference point, 8s delay2.22.32.41.51.5-1.61.6-1.51.5-1.51.51.51.5-1.51.51.5-1.5
Delay discount exponential model param2.72.82.9-1.7-1.71.7-1.71.7-1.71.6-1.7-1.7-1.71.7-1.7-1.71.7
Delay discount hyperbolic model param2.62.82.9-1.7-1.71.7-1.71.7-1.71.6-1.7-1.7-1.61.7-1.7-1.61.7
Fecal boli incidents, locomotor time 10.40.40.5-0.7-0.60.7-0.70.7-0.70.7-0.6-0.7-0.70.7-0.7-0.60.7
Change in fecal boli incidents, locomotor task0.00.00.1-0.2-0.20.1-0.10.1-0.1-0.1-0.0-0.1-0.20.1-0.1-0.20.1
Time >=10cm from walls, locomotor time 10.10.10.40.30.3-0.30.3-0.30.3-0.10.20.40.6-0.40.40.3-0.3
Bouts of movement, locomotor time 10.00.00.0-0.1-0.10.1-0.10.1-0.10.1-0.1-0.1-0.20.1-0.1-0.10.1
Total resting periods, locomotor time 10.00.00.1-0.1-0.10.1-0.10.1-0.10.1-0.1-0.1-0.30.1-0.1-0.10.1
Rest time, locomotor task time 10.60.60.80.80.9-0.80.8-0.80.8-0.70.80.80.4-0.80.80.9-0.8
Distance moved, locomotor task time 11.71.92.1-1.4-1.41.4-1.41.4-1.41.5-1.4-1.4-1.11.4-1.4-1.41.4
Vertical activity count, locomotor time 10.80.81.1-0.9-1.00.9-0.90.9-0.91.0-1.0-0.9-0.50.9-0.9-1.00.9
Time >=10cm from walls, locomotor time 21.61.71.9-1.3-1.31.3-1.31.3-1.31.4-1.3-1.3-1.21.3-1.3-1.31.3
Bouts of movement, locomotor time 20.00.00.1-0.1-0.10.1-0.10.1-0.1-0.20.1-0.1-0.40.1-0.1-0.00.1
Total resting periods, locomotor time 20.10.10.30.20.2-0.20.2-0.20.2-0.60.40.2-0.1-0.20.20.2-0.2
Rest time, locomotor task time 20.00.00.10.20.2-0.10.2-0.10.2-0.30.30.2-0.1-0.20.20.2-0.2
Distance moved, locomotor task time 21.01.11.7-1.0-1.11.1-1.11.1-1.01.3-1.2-1.0-0.61.0-1.0-1.11.1
Vertical activity count, locomotor time 20.10.10.2-0.3-0.30.2-0.30.2-0.30.4-0.3-0.30.20.3-0.3-0.30.3
Weight adjusted by age0.20.30.3-0.5-0.50.5-0.50.5-0.50.3-0.5-0.5-0.60.5-0.5-0.50.5
Seeking ratio, delayed vs. immediate footshock2.63.03.31.81.8-1.81.8-1.81.8-1.61.81.81.5-1.81.81.4-1.8
Locomotion in novel chamber0.20.20.40.50.5-0.50.5-0.50.50.10.30.50.2-0.50.50.6-0.5
Locomotion in novel chamber post-restriction0.81.01.4-1.0-0.90.9-0.90.9-1.01.1-1.0-1.0-1.21.0-1.0-0.91.0
Progressive ratio3.74.35.2-2.0-2.12.1-2.12.1-2.02.2-2.1-2.0-2.32.0-2.0-1.92.0
Food seeking constrained by brief footshock0.70.80.91.01.0-1.01.0-1.01.0-0.30.81.00.9-1.01.01.0-1.0
Seeking ratio, punishment vs. effort5.56.87.52.62.6-2.62.6-2.62.6-2.42.52.62.7-2.62.62.6-2.6
Run reversals in cocaine runway, females1.91.82.31.41.3-1.41.4-1.51.3-1.31.21.41.5-1.31.31.3-1.3
Run reversals in cocaine runway, males0.60.60.8-0.7-0.90.8-0.80.8-0.70.8-0.8-0.7-0.20.7-0.7-0.80.7
Latency to leave start box in cocaine runway0.40.41.1-0.6-0.70.7-0.70.7-0.61.0-0.8-0.6-0.30.6-0.6-0.50.6
Latency to leave start box in cocaine runway, F1.51.62.3-1.2-1.31.3-1.31.4-1.21.5-1.3-1.2-1.21.2-1.2-1.11.2
Latency to leave start box in cocaine runway, M0.40.40.60.60.8-0.70.7-0.60.6-0.20.40.60.8-0.60.60.6-0.6
Cd content in liver2.22.42.8-1.7-1.41.6-1.71.4-1.61.5-1.4-1.6-1.51.6-1.6-1.41.6
Co content in liver0.10.10.8-0.1-0.20.2-0.20.2-0.1-0.90.2-0.1-0.10.1-0.10.10.1
Cu content in liver4.15.05.6-2.3-2.22.2-2.22.2-2.32.4-2.2-2.3-2.32.2-2.2-2.12.2
Fe content in liver1.51.82.3-1.5-1.11.4-1.41.1-1.41.5-1.2-1.4-1.11.4-1.4-1.01.4
K content in liver0.80.81.1-0.8-1.00.8-0.80.9-0.80.8-1.0-0.9-1.00.9-0.9-0.90.9
Mg content in liver0.00.00.10.0-0.20.1-0.10.3-0.00.0-0.2-0.0-0.30.0-0.0-0.10.0
Mn content in liver0.70.91.2-0.9-1.11.0-0.91.1-0.90.6-0.9-0.9-1.10.9-0.9-0.90.9
Na content in liver0.30.30.4-0.6-0.40.5-0.60.4-0.60.5-0.5-0.6-0.40.6-0.6-0.40.6
Rb content in liver0.81.01.7-1.2-0.91.3-1.30.9-1.20.3-0.6-1.1-0.81.1-1.1-0.61.1
Se content in liver0.00.00.2-0.1-0.1-0.10.10.0-0.10.5-0.4-0.1-0.10.2-0.1-0.30.2
Sr content in liver0.10.00.1-0.0-0.30.1-0.10.3-0.00.3-0.3-0.1-0.30.1-0.1-0.30.1
Zn content in liver4.95.47.3-2.2-2.32.3-2.32.4-2.22.7-2.4-2.3-2.42.3-2.3-2.12.3