Hub : Genes

Epm2aip1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	ENSRNOG00000043006	0.09	0.07	4.9e-04	0.04	0.05	0.06	0.04	3.3e-03	1.0e-03	5.3e-04	5.4e-03
2	Brain	gene expression	ENSRNOG00000043006	0.03	0.03	9.6e-03	0.02	0.02	0.01	0.02	8.5e-03	7.9e-03	3.4e-02	1.1e-02
3	NAcc	gene expression	ENSRNOG00000043006	0.09	0.05	4.9e-09	0.13	0.11	0.09	0.12	4.5e-10	2.0e-08	5.6e-07	4.2e-09
4	PL	gene expression	ENSRNOG00000043006	0.07	0.04	3.1e-06	0.08	0.08	0.06	0.07	2.0e-06	1.9e-06	2.6e-05	2.4e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
BMI with tail	0.5	1.7	3.1	-1.1	1.2	1.8	-1.1
BMI without tail	1.6	3.3	4.7	-1.3	1.8	2.2	-1.9
Body weight	6.8	28.8	33.0	-5.0	5.5	5.7	-5.2
Epididymis fat weight	0.3	0.7	1.2	-0.6	0.8	1.1	-0.8
Glucose	0.2	0.3	0.5	0.2	0.5	0.5	-0.7
Heart weight	2.3	3.3	4.9	-2.2	1.8	1.6	-1.5
Left kidney weight	0.5	1.3	2.0	0.6	1.0	1.4	-1.4
Right kidney weight	0.2	0.6	0.8	0.9	0.4	0.9	-0.7
Tail length	6.3	19.0	21.1	-3.8	4.6	4.5	-4.5
Length with tail	8.9	32.6	36.1	-5.1	6.0	5.8	-5.9
Length without tail	6.8	14.8	15.8	-3.7	4.0	4.0	-3.8
Liver weight, left	0.1	0.2	0.5	0.7	0.0	0.0	-0.4
Liver weight, right	1.0	1.6	2.5	-0.5	1.3	1.6	-1.5
Parametrial fat weight	0.6	1.1	1.7	-0.5	1.2	1.0	-1.3
Retroperitoneal fat weight	0.5	1.6	2.3	-0.5	1.3	1.5	-1.4
Intraocular pressure	0.9	1.3	1.6	-1.1	1.2	1.1	-1.3
Extensor digitorum longus weight	0.1	0.5	0.8	0.1	-0.7	-0.7	0.9
Soleus weight	3.8	11.0	12.7	-3.0	3.4	3.6	-3.3
Tibialis anterior weight	0.0	0.1	0.2	-0.5	0.2	0.3	-0.1
Tibia length	6.6	18.6	22.9	-3.6	4.4	4.8	-4.4
Number of licking bursts	0.2	0.2	0.3	-0.4	-0.4	-0.4	0.5
Food consumed during 24 hour testing period	1.5	1.8	1.9	-1.4	1.3	1.4	-1.3
Times rat made contact with spout	0.3	0.4	0.5	-0.7	0.6	0.6	-0.6
Mean time between licks in bursts	0.8	1.1	1.5	0.6	-1.1	-1.1	1.2
Mean num. licks in bursts	0.4	0.5	0.8	-0.0	0.7	0.8	-0.9
Std. dev. time between licks in bursts	2.6	3.1	4.4	0.8	-1.9	-1.9	2.1
Water consumed over 24 hours	0.1	0.1	0.4	-0.6	-0.1	-0.0	0.2
Indifference point 0 sec	1.1	1.7	2.4	-0.6	1.4	1.5	-1.5
Indifference point AUC	0.1	0.2	0.3	0.6	0.3	0.3	-0.4
Indifference point function ln k	0.1	0.1	0.2	0.3	-0.4	-0.2	0.4
Indifference point function log k	0.1	0.1	0.2	0.3	-0.4	-0.2	0.4
Delay discounting total patch changes 0 sec	1.3	2.2	2.7	-1.0	1.6	1.6	-1.6
Delay discounting total patch changes 12 sec	0.7	0.9	1.2	-0.6	1.1	0.9	-1.1
Delay discounting total patch changes 18 sec	2.7	3.5	4.8	-1.4	2.1	1.7	-2.2
Delay discounting total patch changes 24 sec	2.7	3.4	3.9	-1.6	2.0	1.8	-2.0
Delay discounting total patch changes 6 sec	0.1	0.2	0.3	0.6	0.3	0.4	-0.5
Delay discounting time to switch 0 sec	0.3	0.4	0.8	0.0	-0.6	-0.9	0.7
Delay discounting water rate 0 sec	0.3	0.5	0.7	-0.8	0.7	0.7	-0.6
Delay discounting water rate 12 sec	0.3	0.5	0.6	-0.7	0.7	0.8	-0.6
Delay discounting water rate 18 sec	0.2	0.2	0.5	-0.7	0.1	0.7	-0.0
Delay discounting water rate 24 sec	0.7	1.0	1.4	-0.9	0.9	1.2	-0.9
Delay discounting water rate 6 sec	0.3	0.4	0.5	-0.3	0.7	0.6	-0.7
Locomotor activity	6.1	9.6	10.5	-2.9	3.2	3.1	-3.1
Locomotor testing distance	5.6	9.3	10.1	-2.8	3.2	3.1	-3.1
Locomotor testing rearing	0.4	0.6	0.8	-0.9	0.8	0.7	-0.8
Light reinforcement 1	0.5	0.9	1.4	-0.6	0.9	1.2	-1.0
Light reinforcement 2	0.5	0.7	2.1	1.5	-0.7	-0.0	0.4
Reaction time number correct	0.2	0.4	0.5	0.3	-0.7	-0.6	0.6
Reaction time mean minus median	0.0	0.0	0.1	0.4	0.0	-0.1	-0.1
Reaction time mean minus median AUC	0.1	0.1	0.2	0.1	0.3	0.3	-0.5
Reaction time num false alarms	0.3	0.4	0.6	0.8	-0.6	-0.6	0.5
Reaction time num false alarms AUC	0.1	0.2	0.6	0.8	-0.3	-0.3	0.2
Reaction time trials correct on left	0.2	0.4	0.5	0.3	-0.7	-0.6	0.6
Reaction time trials on left	0.3	0.4	0.5	0.4	-0.7	-0.7	0.7
Reaction time mean	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.1
Reaction time mean AUC	0.0	0.0	0.0	0.2	-0.0	-0.2	-0.1
Median of all reaction times	0.0	0.0	0.0	-0.2	0.1	-0.1	-0.1
Reaction time omissions	0.4	0.6	1.3	0.3	-0.7	-1.1	0.7
Reaction time false alarm rate	0.1	0.1	0.3	0.6	-0.2	-0.1	0.1
Reaction time premature initiation rate	1.4	1.8	2.3	-0.9	1.4	1.5	-1.4
Reaction time premature initiations	0.6	0.8	1.1	-0.6	0.9	1.1	-0.9
Std. dev. reaction times	0.1	0.1	0.2	0.2	0.3	0.1	-0.4
Reaction time trials completed	0.3	0.4	0.5	0.4	-0.7	-0.7	0.7
Reaction time trials AUC	0.3	0.5	0.6	0.4	-0.8	-0.8	0.7
Social response proportion	0.2	0.2	0.2	-0.5	0.4	0.1	-0.5
Social responses	0.2	0.3	0.5	-0.2	0.5	0.6	-0.7
Social time	1.0	1.2	2.0	0.0	-1.1	-1.4	1.3
Conditioned locomotion	3.2	3.7	4.1	2.0	-2.0	-2.0	1.8
Cocaine response after cond. corrected	0.5	0.5	1.6	-1.3	0.4	0.4	-0.3
Cocaine response after cond. not corrected	2.0	2.3	3.9	-2.0	1.4	1.3	-1.2
Cocaine response before conditioning	1.1	1.3	1.7	-0.7	1.2	1.3	-1.2
Saline control response	1.2	1.6	2.4	-0.4	1.4	1.3	-1.6
Condit. Reinf. active minus inactive responses	2.4	3.0	3.4	-1.7	1.8	1.7	-1.6
Condit. Reinf. active-inactive response ratio	1.7	1.8	2.1	-1.5	1.3	1.4	-1.2
Condit. Reinf. active responses	2.0	2.8	3.2	-1.8	1.7	1.6	-1.5
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.2	0.1	-0.2	0.1
Condit. Reinf. lever presses	2.6	3.5	4.1	-1.7	2.0	2.0	-1.8
Condit. Reinf. lever reinforcers received	2.3	3.2	3.5	-1.9	1.9	1.8	-1.7
Pavlov. Cond. lever latency	0.6	0.8	0.9	0.7	-1.0	-0.9	0.8
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.1	-0.2	-0.1	0.3
Pavlov. Cond. change in total contacts	2.9	4.0	4.5	-2.0	2.1	2.0	-1.9
Pavlov. Cond. index score	0.2	0.2	0.3	-0.5	0.5	0.5	-0.4
Pavlov. Cond. latency score	0.1	0.2	0.2	-0.4	0.4	0.5	-0.3
Pavlov. Cond. lever contacts	1.0	1.4	1.7	-0.9	1.3	1.3	-1.3
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.2	0.4	0.4	-0.5
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.6	0.6	-0.6	-0.8	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.3	-0.5	0.5	0.5	-0.3
Pavlov. Cond. response bias	0.1	0.2	0.2	-0.4	0.5	0.5	-0.4
Conditioned reinforcement - actives	0.0	0.0	0.1	0.2	-0.3	-0.1	0.2
Conditioned reinforcement - inactives	0.6	0.6	1.2	-0.2	-0.9	-0.7	1.1
Conditioned locomotion	0.4	0.4	1.0	1.0	-0.6	-0.4	0.4
Intermittent access intake day 1-15 change	0.4	0.4	0.6	-0.6	-0.5	-0.5	0.8
Intermittent access intake escalation	0.3	0.3	0.4	-0.6	-0.4	-0.4	0.6
Intermittent access intake escalation 2	0.5	0.5	2.0	-1.4	0.3	0.0	0.0
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	0.0	-0.1	0.0	0.1
Intermitt. access day 15 inactive lever presses	0.6	0.6	1.3	0.1	-0.9	-0.7	1.1
Intermitt. access escalation Index	0.1	0.1	0.4	0.6	0.0	-0.2	-0.2
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.2	-0.0	0.1	-0.0
Intermittent access day 15 total infusions	0.1	0.1	0.1	-0.1	-0.3	-0.2	0.4
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1
Intermittent access total infusions	0.1	0.1	0.2	0.2	-0.4	-0.2	0.4
Intermittent access day 1 locomotion	0.2	0.2	0.4	0.6	-0.4	-0.2	0.3
Intermittent access day 15 total locomotion	0.5	0.6	1.0	1.0	-0.8	-0.6	0.6
Intermittent access total locomotion	1.0	1.1	2.0	1.4	-1.1	-0.8	0.9
Intermittent access standard deviation	0.9	0.9	3.2	-1.8	0.7	0.4	-0.3
Cocaine induced anxiety	0.5	0.6	0.8	0.2	-0.8	-0.9	0.9
Post-drug Anxiety	0.4	0.4	0.5	0.4	-0.7	-0.7	0.7
Baseline Anxiety	0.2	0.2	0.4	0.6	-0.4	-0.4	0.4
Lifetime Intake	0.1	0.1	0.2	0.4	-0.4	-0.2	0.3
Incentive Sensitization - Responses	1.6	1.6	2.2	0.7	-1.4	-1.3	1.5
Incentive Sensitization - Breakpoint	1.5	1.5	2.1	0.7	-1.3	-1.3	1.4
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	0.4	0.0	0.1	-0.2
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	0.5	-0.1	-0.0	-0.1
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.5	-0.1	-0.6	-0.5	0.7
Progressive ratio test 2 active lever presses	0.6	0.7	0.8	0.7	-0.9	-0.8	0.9
Progressive ratio test 2 breakpoint	0.5	0.5	0.7	0.6	-0.8	-0.7	0.8
Progressive ratio test 2 inactive lever presses	1.2	1.3	2.4	0.2	-1.3	-1.1	1.5
Total sessions with >9 infusions	0.1	0.1	0.2	-0.5	-0.1	0.3	0.2
Short access day 1 total inactive lever presses	2.0	2.3	3.1	1.1	-1.7	-1.3	1.8
Short access day 10 total inactive lever presses	0.2	0.3	0.6	-0.8	-0.2	-0.5	0.5
Short access day 1 total infusions	0.6	0.7	0.9	0.7	-1.0	-0.7	0.9
Short access day 10 total infusions	0.0	0.0	0.1	0.1	0.0	0.3	-0.1
Short access total infusions	0.3	0.4	0.6	0.8	-0.7	-0.4	0.5
Short access day 1 locomotion	0.1	0.2	0.5	0.3	-0.2	0.7	0.1
Short access day 10 total locomotion	0.2	0.2	0.3	0.5	0.2	0.5	-0.4
Short access total locomotion	0.2	0.2	0.6	0.7	-0.2	0.4	-0.2
Compulsive drug intake	0.2	0.2	0.8	0.9	-0.2	-0.3	-0.0
One hour access (0.3 mA shock)	0.1	0.1	0.2	0.5	-0.2	-0.2	0.0
One hour access (shock baseline)	0.0	0.0	0.1	-0.3	0.0	-0.0	0.0
Number of responses in last shaping day	0.3	0.3	0.7	0.0	-0.7	-0.4	0.8
Context. condit. distance diff. score	0.0	0.0	0.1	-0.3	0.1	0.0	0.0
Locomotion velocity, session 1	0.1	0.1	0.2	0.4	-0.2	-0.2	0.2
Locomotion distance, session 1	0.8	1.0	1.6	-0.1	1.1	1.3	-1.2
Locomotion velocity, session 2	0.2	0.2	0.3	0.6	-0.5	-0.4	0.5
Locomotion distance, session 2	0.2	0.3	1.0	1.0	-0.0	0.2	-0.2
Locomotion velocity, session 3	0.2	0.2	0.3	0.6	0.3	0.5	-0.4
Locomotion distance, session 3	1.0	1.1	2.5	1.6	-0.9	-0.7	0.8
Stereotopy head waving bouts, day 3	0.4	0.5	1.9	-1.4	0.2	0.2	0.0
Stereotopy head waving duration, day 3	0.5	0.6	1.7	-1.3	0.6	0.5	-0.4
Locomotion velocity, session 7	0.3	0.3	0.6	0.3	0.6	0.6	-0.8
Locomotion distance, session 7	0.7	0.9	2.0	1.4	-0.8	-0.7	0.6
Stereotopy head waving bouts, day 7	0.3	0.3	0.8	0.9	-0.4	-0.4	0.2
Stereotopy head waving duration, day 7	0.1	0.1	0.3	0.1	0.4	0.4	-0.5
Locomotion velocity, session 8	0.3	0.4	0.6	-0.0	0.7	0.8	-0.6
Locomotion distance, session 8	0.4	0.5	0.7	0.6	0.6	0.9	-0.8
Degree of sensitization distance	1.1	1.1	1.3	-1.1	1.0	0.9	-1.1
Degree of sensitization stereotypy	0.3	0.3	1.2	1.1	-0.2	-0.2	-0.1
Condit. Reinf. active minus inactive responses	0.1	0.2	0.4	-0.6	0.3	0.1	-0.3
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.9	-1.0	0.5	0.3	-0.4
Condit. Reinf. active responses	0.0	0.1	0.1	0.0	-0.2	-0.3	0.2
Condit. Reinf. inactive responses	0.8	1.0	1.3	1.1	-1.0	-0.9	0.9
Incentive salience index mean	0.0	0.1	0.1	0.1	-0.3	-0.3	0.2
Condit. Reinf. lever presses	1.4	1.9	2.1	1.4	-1.4	-1.3	1.3
Time in familiar zone, hab. session 1	0.9	0.8	1.2	0.2	-0.9	-1.1	1.1
Time in novel zone, hab. session 1	0.3	0.3	0.3	-0.4	0.5	0.6	-0.6
Total zone transitions, hab. session 1	0.5	0.7	1.3	0.2	0.8	1.1	-1.0
Total locomotion distance, hab. session 1	0.2	0.3	0.5	0.1	0.5	0.7	-0.6
Locomotion velocity, hab. session 1	0.2	0.3	0.5	0.3	0.6	0.7	-0.7
Time in familiar zone, hab. session 2	0.2	0.2	0.4	-0.2	-0.4	-0.6	0.7
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.2	-0.0	0.0	-0.2
Total zone transitions, hab. session 2	0.1	0.1	0.2	0.4	0.2	0.5	-0.3
Total locomotion distance, hab. session 2	0.2	0.3	0.5	0.1	0.5	0.7	-0.6
Locomotion velocity, hab. session 2	0.2	0.2	0.3	0.4	0.4	0.5	-0.5
Novel to familiar place preference ratio	0.9	0.9	1.6	0.5	0.9	1.0	-1.3
Novelty place preference	0.9	0.9	1.6	0.6	0.8	0.9	-1.3
Time in novel zone, NPP test	1.0	1.0	1.9	0.3	1.0	1.1	-1.4
Total zone transitions, NPP test	2.0	2.9	4.8	-0.4	1.7	2.2	-2.0
Total locomotion distance, NPP test	0.8	1.1	1.8	-0.4	1.1	1.3	-1.2
Locomotion velocity, NPP test	0.9	1.3	2.0	-0.3	1.2	1.4	-1.3
Pavlov. Cond. lever latency	4.8	6.1	6.4	-2.4	2.5	2.5	-2.5
Pavlov. Cond. magazine entry latency	5.7	7.4	8.6	2.2	-2.8	-2.9	2.9
Pavlov. Cond. change in total contacts	1.2	1.3	1.7	0.9	-1.1	-1.3	1.2
Pavlov. Cond. index score	5.6	7.2	8.3	2.2	-2.7	-2.9	2.8
Pavlov. Cond. latency score	5.6	7.1	7.9	2.4	-2.7	-2.8	2.8
Pavlov. Cond. lever contacts	2.8	3.3	3.3	1.8	-1.8	-1.8	1.8
Pavlov. Cond. magazine entry number	6.6	8.3	9.5	-2.4	2.9	3.1	-3.0
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.5	-0.6	0.7	0.7	-0.7
Pavlov. Cond. lever-magazine prob. diff.	4.8	6.1	7.3	1.8	-2.5	-2.7	2.7
Pavlov. Cond. response bias	6.2	7.6	8.7	2.2	-2.8	-2.9	3.0
Bone: apparent density	0.1	0.1	0.2	0.4	0.2	0.2	-0.3
Bone surface	0.0	0.1	0.2	0.4	-0.2	-0.2	0.2
Bone volume	0.0	0.0	0.1	0.4	-0.0	-0.0	0.0
Bone: connectivity density	0.4	0.6	1.3	1.2	-0.6	-0.7	0.4
Bone: cortical apparent density	0.4	0.5	0.7	0.8	-0.6	-0.8	0.6
Bone: cortical area	0.1	0.2	0.3	-0.6	-0.2	-0.4	0.5
Bone: cortical porosity	0.3	0.3	1.0	1.0	-0.3	-0.4	-0.1
Bone: cortical porosity	0.4	0.4	1.2	1.1	-0.5	-0.5	0.1
Bone: cortical thickness	0.4	0.6	1.8	-1.3	0.6	0.4	-0.2
Bone: cortical thickness	0.0	0.0	0.0	-0.0	0.1	0.1	-0.1
Bone: cortical tissue density	0.4	0.5	0.8	0.9	-0.6	-0.8	0.6
Bone: elastic displacement	0.2	0.3	0.9	-1.0	0.4	0.2	-0.1
Bone: elastic work	0.9	1.1	1.9	-1.4	1.1	1.0	-0.8
Bone: endosteal estimation	0.1	0.2	0.3	-0.3	0.5	0.4	-0.6
Bone: endosteal perimeter	1.0	2.1	2.5	1.3	-1.6	-1.5	1.5
Bone: final force	0.9	1.5	2.4	-1.5	1.2	1.1	-1.0
Bone: final moment	1.3	2.1	3.3	-1.8	1.4	1.3	-1.2
Bone: marrow area	0.1	0.2	0.4	-0.3	0.5	0.5	-0.6
Bone: maximum diameter	0.3	0.6	0.9	0.1	-0.8	-0.8	1.0
Bone: maximum force	0.8	1.4	1.8	-1.3	1.2	1.1	-1.1
Bone: maximum moment	0.9	1.7	2.3	-1.5	1.3	1.2	-1.1
Bone: minimum diameter	0.2	0.4	0.6	0.4	-0.7	-0.7	0.8
Bone: periosteal estimation	0.1	0.1	0.3	-0.5	0.3	0.2	-0.2
Bone: periosteal perimeter	0.9	1.5	1.9	0.8	-1.3	-1.4	1.4
Bone: post-yield work	0.0	0.0	0.1	-0.1	0.1	0.2	-0.2
Bone: stiffness	0.1	0.2	0.2	-0.4	0.5	0.4	-0.5
Bone: tissue strength	4.0	3.9	5.3	-2.3	2.0	1.9	-1.7
Bone: trabecular number	0.7	1.1	2.1	1.4	-0.9	-0.9	0.8
Bone: trabecular spacing	1.4	1.8	2.7	-1.7	1.3	1.3	-1.1
Bone: trabecular thickness	0.1	0.1	0.4	0.6	0.2	0.2	-0.3
Bone: trabecular tissue density	0.1	0.2	0.3	-0.0	0.5	0.5	-0.6
Breakpoint value in progressive ratio session	0.0	0.0	0.1	0.1	0.2	0.2	-0.3
Distance traveled before self-admin	0.3	0.3	1.1	-1.1	0.2	0.2	-0.0
Distance traveled after self-admin	0.3	0.4	0.9	0.0	-0.4	-0.9	0.6
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	0.7	-0.4	-0.3	0.3
Delta time in open arm before/after self-admin	0.2	0.2	0.3	-0.2	0.6	0.4	-0.5
Diff in mean of infusions in LGA sessions	0.1	0.1	0.4	-0.7	-0.1	-0.1	0.3
Extinction: sum of active levers before priming	0.1	0.1	0.3	0.3	0.2	0.5	-0.4
Active lever presses in extinction session 6	0.4	0.4	0.6	-0.0	0.6	0.8	-0.8
Delta distance traveled before/after self-admin	0.4	0.5	0.8	0.9	-0.6	-0.6	0.5
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	0.1	0.4	-0.1	-0.4
Time in closed arm before self-admin	2.1	2.4	3.1	-1.8	1.5	1.4	-1.4
Time in closed arm after self-admin	0.0	0.0	0.1	-0.3	0.2	0.1	-0.2
Time in open arm before self-admin	1.4	1.5	1.8	1.2	-1.3	-1.1	1.3
Time in open arm after self-admin	0.5	0.6	1.8	1.3	-0.5	-0.5	0.3
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.4	-0.2	0.6	0.6	-0.7
Time to tail flick, vehicle, before self-admin	2.0	2.0	2.1	-1.4	1.4	1.4	-1.4
Time to tail flick, vehicle, after self-admin	0.5	0.5	1.3	-1.1	0.8	-0.0	-0.5
Time to tail flick, test, before self-admin	0.4	0.4	1.4	1.2	-0.3	-0.1	-0.0
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.1	-0.3	0.0	0.4
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.7	0.2	-0.6	-1.3	0.9
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	-0.4	-0.1	0.1	0.3
Ambulatory time before self-admin	0.2	0.2	0.6	-0.8	-0.0	-0.1	0.2
Ambulatory time after self-admin	0.1	0.1	0.4	0.2	-0.2	-0.6	0.2
Total heroin consumption	1.2	1.4	1.9	-1.4	1.2	1.1	-1.0
Area under the delay curve	2.4	2.6	3.6	1.9	-1.6	-1.5	1.4
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	0.2	-0.1	0.5	0.0
Delay disc. indifference point, 16s delay	1.4	1.5	2.0	1.3	-1.1	-1.4	1.0
Delay disc. indifference point, 2s delay	0.3	0.3	0.4	0.6	-0.6	-0.3	0.5
Delay disc. indifference point, 24s delay	1.2	1.1	1.5	1.1	-1.0	-1.2	0.9
Delay disc. indifference point, 4s delay	2.1	2.2	2.5	1.6	-1.6	-1.3	1.5
Delay disc. indifference point, 8s delay	2.4	2.5	3.2	1.8	-1.5	-1.6	1.4
Delay discount exponential model param	2.7	2.9	3.6	-1.9	1.7	1.6	-1.6
Delay discount hyperbolic model param	2.7	2.9	3.7	-1.9	1.7	1.6	-1.5
Fecal boli incidents, locomotor time 1	0.6	0.6	0.8	-0.9	0.8	0.8	-0.7
Change in fecal boli incidents, locomotor task	0.2	0.1	0.5	0.2	0.1	0.7	-0.2
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.8	0.9	-0.5	-0.8	0.3
Bouts of movement, locomotor time 1	0.0	0.1	0.2	-0.2	0.1	-0.4	-0.1
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.2	0.2	-0.4	-0.1
Rest time, locomotor task time 1	0.4	0.4	0.6	0.7	-0.8	-0.5	0.6
Distance moved, locomotor task time 1	1.7	1.9	2.3	-1.5	1.4	1.4	-1.2
Vertical activity count, locomotor time 1	0.6	0.6	0.7	-0.7	0.9	0.8	-0.8
Time >=10cm from walls, locomotor time 2	1.6	1.7	2.3	-1.0	1.3	1.5	-1.3
Bouts of movement, locomotor time 2	0.2	0.2	0.5	-0.7	0.3	0.4	-0.2
Total resting periods, locomotor time 2	0.0	0.0	0.2	-0.4	0.0	0.1	0.1
Rest time, locomotor task time 2	0.0	0.0	0.1	0.2	-0.1	-0.3	-0.0
Distance moved, locomotor task time 2	0.8	0.9	1.3	-1.1	0.9	1.0	-0.8
Vertical activity count, locomotor time 2	0.0	0.0	0.0	-0.1	0.1	0.0	-0.1
Weight adjusted by age	0.5	0.6	1.4	-1.2	0.6	0.5	-0.4
Seeking ratio, delayed vs. immediate footshock	2.1	2.5	3.4	1.9	-1.7	-1.1	1.5
Locomotion in novel chamber	0.1	0.1	0.1	-0.2	-0.3	0.1	0.4
Locomotion in novel chamber post-restriction	0.7	0.8	1.2	-0.7	1.0	0.8	-1.1
Progressive ratio	3.8	4.4	5.8	-1.6	2.1	2.4	-2.2
Food seeking constrained by brief footshock	0.5	0.6	0.8	0.7	-0.9	-0.6	0.9
Seeking ratio, punishment vs. effort	5.1	6.2	7.5	1.9	-2.6	-2.6	2.7
Run reversals in cocaine runway, females	1.8	1.8	2.3	1.0	-1.4	-1.4	1.5
Run reversals in cocaine runway, males	0.3	0.3	0.6	-0.8	0.6	0.4	-0.3
Latency to leave start box in cocaine runway	0.2	0.2	0.3	-0.4	0.5	0.5	-0.4
Latency to leave start box in cocaine runway, F	1.5	1.6	3.2	-1.8	1.3	1.0	-0.9
Latency to leave start box in cocaine runway, M	0.7	0.7	2.0	1.4	-0.7	-0.3	0.5
Cd content in liver	2.8	3.1	4.5	-2.1	1.7	1.5	-1.6
Co content in liver	0.1	0.2	0.5	-0.7	0.3	0.1	-0.1
Cu content in liver	4.1	4.9	5.6	-1.9	2.3	2.2	-2.4
Fe content in liver	2.0	2.4	3.8	-1.9	1.6	1.1	-1.4
K content in liver	0.7	0.7	0.9	-0.3	1.0	0.9	-0.9
Mg content in liver	0.0	0.0	0.1	0.3	0.2	0.2	-0.1
Mn content in liver	0.7	0.8	1.1	-0.1	1.0	1.0	-1.0
Na content in liver	0.3	0.3	0.5	-0.5	0.7	0.4	-0.6
Rb content in liver	1.5	1.9	4.2	-2.1	1.3	0.8	-1.1
Se content in liver	0.0	0.0	0.0	-0.0	0.1	0.2	0.0
Sr content in liver	0.1	0.1	0.2	0.4	-0.0	0.3	-0.1
Zn content in liver	4.5	5.0	5.9	-1.7	2.4	2.4	-2.4