Hub : Traits

Bone: cortical area

Tags: Physiology · Bone

Project: r01_doug_adams

1 loci · 1 genes with independent associations · 4 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	10	105499327	107195627	4	1	9.12e-14	1.54e-09	1.52e-02	Ccdc57

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	6.09	2	1	100	0	1.00e+00	Ccdc57 ENSRNOG00000068691
BMI without tail	5.79	2	0	0	0	1.00e+00	Ccdc57 B3gntl1
Body weight	8.22	4	1	100	1	9.40e-05	Tbcd Ccdc57 B3gntl1 ENSRNOG00000068691
Heart weight	5.19	2	0	0	0	1.00e+00	Ccdc57 ENSRNOG00000068691
Left kidney weight	3.62	2	0	0	0	1.00e+00	Ccdc57 ENSRNOG00000068691
Right kidney weight	3.43	2	0	0	0	1.00e+00	Ccdc57 ENSRNOG00000068691
Tail length	3.07	1	0	0	0	1.00e+00	B3gntl1
Length with tail	2.73	4	0	0	0.99	6.03e-04	Tbcd Ccdc57 B3gntl1 ENSRNOG00000068691
Length without tail	4.27	1	0	0	0	1.00e+00	ENSRNOG00000068691
Retroperitoneal fat weight	2.56	3	0	0	0	1.00e+00	Tbcd Ccdc57 B3gntl1
Tibia length	20.4	4	4	400	0.99	1.23e-03	Tbcd Ccdc57 B3gntl1 ENSRNOG00000068691
Delay discounting water rate 12 sec	5.51	1	0	0	0	1.00e+00	Ccdc57
Delay discounting water rate 24 sec	8.59	1	0	0	0	1.00e+00	Ccdc57
Delay discounting water rate 6 sec	6.89	1	0	0	0	1.00e+00	Ccdc57
Conditioned locomotion	5.88	1	0	0	0	1.00e+00	B3gntl1
Condit. Reinf. active minus inactive responses	6.7	1	0	0	0	1.00e+00	B3gntl1
Condit. Reinf. active-inactive response ratio	6.83	3	0	0	0	1.00e+00	Tbcd B3gntl1 ENSRNOG00000068691
Locomotion distance, session 7	5.32	1	0	0	0	1.00e+00	ENSRNOG00000068691
Bone: cortical thickness	26.03	4	3	300	1	1.71e-04	Tbcd Ccdc57 B3gntl1 ENSRNOG00000068691
Bone: cortical thickness	16.85	2	0	0	0	1.00e+00	Ccdc57 ENSRNOG00000068691
Bone: cortical tissue density	5.64	1	0	0	0	1.00e+00	B3gntl1
Bone: elastic work	12.24	4	0	0	0.99	9.38e-04	Tbcd Ccdc57 B3gntl1 ENSRNOG00000068691
Bone: final force	20.78	4	1	100	1	2.23e-05	Tbcd Ccdc57 B3gntl1 ENSRNOG00000068691
Bone: final moment	21.56	4	1	100	1	8.22e-08	Tbcd Ccdc57 B3gntl1 ENSRNOG00000068691
Bone: maximum diameter	6.09	4	0	0	1	3.08e-04	Tbcd Ccdc57 B3gntl1 ENSRNOG00000068691
Bone: maximum force	21.24	4	3	300	1	1.38e-06	Tbcd Ccdc57 B3gntl1 ENSRNOG00000068691
Bone: maximum moment	21.82	4	4	400	1	9.50e-06	Tbcd Ccdc57 B3gntl1 ENSRNOG00000068691
Bone: minimum diameter	6.43	4	0	0	0.99	1.38e-03	Tbcd Ccdc57 B3gntl1 ENSRNOG00000068691
Bone: periosteal estimation	7.59	4	0	0	0.99	6.18e-04	Tbcd Ccdc57 B3gntl1 ENSRNOG00000068691
Bone: periosteal perimeter	8.46	4	0	0	0.98	4.35e-03	Tbcd Ccdc57 B3gntl1 ENSRNOG00000068691
Bone: stiffness	12.56	2	0	0	0	1.00e+00	Ccdc57 ENSRNOG00000068691
Bone: tissue strength	9.75	1	0	0	0	1.00e+00	Ccdc57
Delta ambulatory time before/after self-admin	6.27	1	0	0	0	1.00e+00	Tbcd

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.56
Adipose	alternative TSS	0	0	1.52
Adipose	gene expression	0	0	1.48
Adipose	isoform ratio	0	0	1.55
Adipose	intron excision ratio	0	0	1.46
Adipose	mRNA stability	1	0	1.53
BLA	alternative polyA	0	0	1.34
BLA	alternative TSS	0	0	1.44
BLA	gene expression	0	0	1.55
BLA	isoform ratio	0	0	1.52
BLA	intron excision ratio	0	0	1.47
BLA	mRNA stability	1	0	1.53
Brain	alternative polyA	0	0	1.51
Brain	alternative TSS	0	0	1.63
Brain	gene expression	0	0	1.53
Brain	isoform ratio	0	0	1.52
Brain	intron excision ratio	0	0	1.48
Brain	mRNA stability	0	0	1.5
Eye	alternative polyA	0	0	1.91
Eye	alternative TSS	0	0	1.65
Eye	gene expression	0	0	1.66
Eye	isoform ratio	0	0	1.51
Eye	intron excision ratio	0	0	1.56
Eye	mRNA stability	0	0	1.62
IL	alternative polyA	0	0	1.57
IL	alternative TSS	0	0	1.26
IL	gene expression	0	0	1.54
IL	isoform ratio	0	0	1.56
IL	intron excision ratio	0	0	1.57
IL	mRNA stability	0	0	1.54
LHb	alternative polyA	0	0	1.51
LHb	alternative TSS	0	0	1.64
LHb	gene expression	0	0	1.56
LHb	isoform ratio	0	0	1.56
LHb	intron excision ratio	0	0	1.39
LHb	mRNA stability	1	0.1	1.51
Liver	alternative polyA	0	0	1.38
Liver	alternative TSS	0	0	1.54
Liver	gene expression	0	0	1.53
Liver	isoform ratio	0	0	1.48
Liver	intron excision ratio	0	0	1.43
Liver	mRNA stability	0	0	1.51
NAcc	alternative polyA	0	0	1.45
NAcc	alternative TSS	2	0.2	1.71
NAcc	gene expression	0	0	1.5
NAcc	isoform ratio	0	0	1.54
NAcc	intron excision ratio	0	0	1.5
NAcc	mRNA stability	0	0	1.53
OFC	alternative polyA	0	0	1.63
OFC	alternative TSS	0	0	1.46
OFC	gene expression	0	0	1.59
OFC	isoform ratio	0	0	1.57
OFC	intron excision ratio	0	0	1.47
OFC	mRNA stability	0	0	1.54
PL	alternative polyA	0	0	1.39
PL	alternative TSS	0	0	1.55
PL	gene expression	0	0	1.55
PL	isoform ratio	0	0	1.54
PL	intron excision ratio	0	0	1.49
PL	mRNA stability	0	0	1.55