Hub : Genes

Atp1b3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000011501 0.1 0.05 3.9e-10 0.09 0.09 0.08 0.08 3.2e-10 8.3e-10 1.8e-09 1.5e-09
2 BLA gene expression ENSRNOG00000011501 0.11 0.06 2.4e-04 0.08 0.06 0.06 0.07 2.9e-05 2.9e-04 2.3e-04 9.3e-05
3 Brain gene expression ENSRNOG00000011501 0.09 0.05 3.5e-05 0.03 0.04 0.05 0.05 1.5e-03 1.0e-04 2.2e-05 1.2e-05
4 Brain intron excision ratio chr8:96922523:96923793 0.05 0.03 1.9e-04 0.04 0.03 0.02 0.03 1.6e-04 1.9e-03 3.9e-03 1.6e-03
5 Brain intron excision ratio chr8:96922523:96941339 0.05 0.03 4.1e-05 0.05 0.04 0.04 0.04 3.3e-05 1.7e-04 7.7e-05 1.7e-04
6 Brain mRNA stability ENSRNOG00000011501 0.37 0.11 0.0e+00 0.33 0.33 0.34 0.34 8.5e-32 8.2e-32 6.7e-32 4.5e-32
7 IL gene expression ENSRNOG00000011501 0.18 0.1 3.7e-03 0.14 0.07 0.06 0.04 3.1e-04 1.1e-02 1.5e-02 4.3e-02
8 IL mRNA stability ENSRNOG00000011501 0.22 0.12 5.4e-03 0.03 0.06 0.06 0.04 7.1e-02 1.8e-02 1.7e-02 3.2e-02
9 Liver gene expression ENSRNOG00000011501 0.29 0.09 0.0e+00 0.21 0.2 0.21 0.21 5.8e-23 5.0e-22 9.2e-23 6.5e-23
10 Liver mRNA stability ENSRNOG00000011501 0.07 0.03 8.2e-08 0.08 0.06 0.06 0.07 6.5e-09 1.2e-07 1.3e-07 3.8e-08
11 NAcc mRNA stability ENSRNOG00000011501 0.1 0.05 4.7e-08 0.11 0.11 0.11 0.1 2.0e-08 1.3e-08 2.5e-08 3.1e-08
12 OFC mRNA stability ENSRNOG00000011501 0.43 0.13 6.0e-08 0.31 0.3 0.25 0.32 3.6e-08 8.8e-08 1.0e-06 2.0e-08
13 PL gene expression ENSRNOG00000011501 0.2 0.08 2.4e-12 0.15 0.16 0.17 0.16 8.2e-12 1.5e-12 7.2e-13 2.8e-12
14 PL mRNA stability ENSRNOG00000011501 0.1 0.04 1.3e-08 0.11 0.11 0.08 0.1 2.0e-08 7.0e-09 9.4e-07 2.6e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
BMI with tail5.517.928.9-2.0-1.55.24.5-5.35.3-1.54.9-1.55.25.04.7-2.85.4
BMI without tail2.55.317.60.20.84.22.0-3.02.90.62.30.72.92.41.9-0.83.3
Body weight4.217.638.5-0.7-0.46.24.4-5.35.3-0.45.2-0.35.24.94.4-1.15.8
Epididymis fat weight0.81.83.6-0.5-1.01.41.4-1.61.6-0.71.5-0.61.31.61.8-0.81.9
Glucose0.20.31.3-0.2-0.30.30.8-0.50.4-0.30.8-0.20.50.61.1-0.70.6
Heart weight0.71.02.8-0.4-0.50.80.7-1.01.0-0.71.3-0.31.11.21.50.31.7
Left kidney weight3.39.415.4-1.7-1.73.33.3-3.93.9-1.63.7-1.43.83.63.0-2.33.8
Right kidney weight2.98.415.3-1.5-1.63.22.9-3.53.5-1.63.8-1.23.53.52.9-1.63.9
Tail length0.92.67.62.22.82.0-0.80.1-0.12.4-0.22.50.1-0.4-0.72.30.9
Length with tail0.41.54.71.31.42.20.4-0.80.91.31.11.40.90.60.11.81.3
Length without tail1.12.36.5-0.5-0.91.71.9-1.51.7-0.62.5-0.51.71.91.60.31.8
Liver weight, left0.20.41.21.10.91.00.2-0.20.21.00.31.00.0-0.1-0.20.50.1
Liver weight, right0.91.53.0-0.7-0.71.41.7-1.31.3-0.61.6-0.61.51.50.9-1.31.1
Parametrial fat weight0.71.43.71.51.90.4-0.70.7-0.61.8-0.71.7-1.0-0.9-0.71.5-0.6
Retroperitoneal fat weight0.72.27.70.80.72.81.2-1.91.81.01.41.01.71.41.20.42.0
Intraocular pressure0.81.23.70.10.51.91.2-1.11.20.21.40.61.31.21.20.11.3
Extensor digitorum longus weight2.07.914.0-1.4-0.93.53.6-3.33.4-0.73.7-0.93.23.43.2-1.63.2
Soleus weight1.23.410.80.80.83.32.2-2.22.30.81.90.82.21.81.9-0.41.9
Tibialis anterior weight0.93.17.7-0.1-0.02.81.6-2.22.30.12.30.12.02.01.9-0.72.5
Tibia length1.02.89.52.12.53.10.5-0.91.02.41.12.50.90.4-0.41.51.0
Number of licking bursts0.81.02.41.41.50.3-0.40.6-0.61.4-0.41.5-0.7-0.8-0.91.3-0.7
Food consumed during 24 hour testing period1.31.65.21.41.5-0.5-1.01.5-1.41.4-0.51.5-1.5-1.1-0.22.3-0.4
Times rat made contact with spout0.40.41.4-0.20.00.61.1-0.50.6-0.01.20.10.40.70.90.70.5
Mean time between licks in bursts0.40.51.1-1.0-0.8-0.01.0-0.60.6-1.10.5-1.00.70.70.2-0.9-0.0
Mean num. licks in bursts1.72.03.5-1.6-1.70.31.4-1.21.2-1.61.4-1.61.31.61.9-1.01.4
Std. dev. time between licks in bursts0.50.62.3-0.9-1.1-1.10.20.1-0.2-1.2-0.5-1.1-0.1-0.00.1-1.5-0.6
Water consumed over 24 hours0.70.82.71.21.40.5-0.30.5-0.41.20.11.4-0.6-0.5-0.41.6-0.3
Indifference point 0 sec0.00.00.2-0.1-0.00.4-0.2-0.10.1-0.10.10.00.20.10.2-0.30.4
Indifference point AUC0.91.13.0-1.6-1.6-1.20.2-0.30.2-1.6-0.1-1.70.20.40.9-1.50.3
Indifference point function ln k0.81.23.01.51.71.5-0.30.1-0.01.60.31.7-0.0-0.3-0.91.5-0.1
Indifference point function log k0.81.23.01.51.71.5-0.30.1-0.01.60.31.7-0.0-0.3-0.91.5-0.1
Delay discounting total patch changes 0 sec0.10.20.5-0.2-0.00.70.2-0.40.4-0.10.4-0.10.50.50.6-0.30.7
Delay discounting total patch changes 12 sec2.33.08.1-2.7-2.4-1.21.1-0.70.7-2.70.8-2.80.81.41.6-1.91.0
Delay discounting total patch changes 18 sec0.40.51.1-1.0-0.7-0.50.2-0.30.4-1.00.5-1.10.10.50.9-1.00.7
Delay discounting total patch changes 24 sec0.10.10.5-0.4-0.4-0.6-0.00.3-0.3-0.4-0.3-0.4-0.20.00.7-0.20.2
Delay discounting total patch changes 6 sec0.20.20.9-0.6-0.6-0.4-0.10.1-0.2-0.8-0.5-0.60.00.00.3-1.00.0
Delay discounting time to switch 0 sec1.72.66.60.20.2-2.6-1.72.0-2.10.0-1.6-0.0-2.0-1.9-1.80.2-2.1
Delay discounting water rate 0 sec1.01.65.90.50.82.41.1-1.31.50.71.00.81.51.21.30.41.8
Delay discounting water rate 12 sec1.32.08.21.00.72.91.3-1.51.81.01.21.31.51.10.70.71.4
Delay discounting water rate 18 sec2.43.28.2-0.00.12.91.9-2.02.20.12.00.22.22.02.10.12.6
Delay discounting water rate 24 sec0.81.13.91.10.92.00.7-0.81.11.30.41.20.80.60.90.71.1
Delay discounting water rate 6 sec1.62.38.61.21.42.91.3-1.31.41.41.41.51.41.11.31.21.6
Locomotor activity0.81.34.40.50.52.10.1-1.41.30.21.10.71.50.91.00.32.0
Locomotor testing distance0.40.72.70.30.11.60.2-1.11.00.10.60.41.20.70.7-0.01.3
Locomotor testing rearing0.50.82.1-0.2-0.31.40.8-1.01.0-0.20.80.11.21.11.0-0.31.3
Light reinforcement 10.20.41.50.91.20.8-0.0-0.00.11.0-0.01.10.0-0.20.01.00.1
Light reinforcement 20.30.41.10.81.00.70.4-0.10.21.10.51.00.1-0.0-0.60.7-0.4
Reaction time number correct0.00.10.10.30.00.0-0.30.3-0.20.1-0.20.4-0.30.00.00.40.4
Reaction time mean minus median0.40.51.1-1.0-1.1-0.40.5-0.20.2-0.90.8-1.00.40.60.6-0.50.5
Reaction time mean minus median AUC0.40.51.0-0.7-0.60.30.9-0.60.7-0.61.0-0.70.70.90.8-0.30.8
Reaction time num false alarms0.50.71.60.50.4-1.0-1.11.0-1.00.3-0.70.5-1.3-1.0-0.90.6-0.7
Reaction time num false alarms AUC0.91.32.70.40.4-1.4-1.41.3-1.30.4-1.00.5-1.7-1.3-1.40.7-1.2
Reaction time trials correct on left0.00.10.10.30.00.0-0.30.3-0.20.1-0.20.4-0.30.00.00.40.4
Reaction time trials on left0.00.10.20.30.00.0-0.30.3-0.20.1-0.20.3-0.30.00.00.40.4
Reaction time mean0.00.00.2-0.2-0.1-0.20.50.0-0.0-0.30.3-0.20.00.1-0.00.2-0.3
Reaction time mean AUC0.10.10.40.10.2-0.30.10.3-0.30.1-0.20.1-0.3-0.2-0.30.4-0.6
Median of all reaction times0.10.20.70.30.5-0.20.20.3-0.30.2-0.20.3-0.3-0.3-0.50.6-0.8
Reaction time omissions0.10.20.7-0.5-0.8-0.8-0.20.3-0.3-0.6-0.3-0.5-0.1-0.1-0.0-0.1-0.0
Reaction time false alarm rate0.50.71.50.40.5-0.9-1.00.9-0.90.5-0.70.5-1.2-1.1-1.20.5-1.1
Reaction time premature initiation rate0.50.71.70.61.0-0.1-0.30.5-0.51.0-1.10.7-0.7-0.8-1.30.7-1.3
Reaction time premature initiations0.30.41.00.40.6-0.2-0.30.5-0.50.6-0.90.5-0.7-0.5-1.00.5-0.9
Std. dev. reaction times0.10.10.4-0.6-0.5-0.40.20.1-0.1-0.60.3-0.60.00.20.3-0.20.0
Reaction time trials completed0.00.10.20.30.00.0-0.30.3-0.20.1-0.20.3-0.30.00.00.40.4
Reaction time trials AUC0.10.10.30.30.0-0.2-0.40.4-0.30.1-0.30.3-0.5-0.1-0.10.50.3
Social response proportion0.20.20.7-0.0-0.3-0.8-0.50.5-0.5-0.3-0.4-0.2-0.4-0.5-0.8-0.1-0.5
Social responses0.10.10.30.30.5-0.20.10.3-0.30.2-0.10.2-0.2-0.2-0.20.4-0.5
Social time0.10.10.30.00.1-0.4-0.10.5-0.50.1-0.20.2-0.4-0.3-0.10.5-0.4
Conditioned locomotion0.80.92.5-0.8-0.9-1.6-1.00.7-0.8-1.1-1.3-1.0-0.6-0.7-0.6-1.2-0.7
Cocaine response after cond. corrected0.40.51.81.01.01.3-0.1-0.40.51.00.11.10.4-0.0-0.10.40.3
Cocaine response after cond. not corrected0.70.82.51.31.31.6-0.2-0.50.51.20.21.30.5-0.1-0.30.70.4
Cocaine response before conditioning0.20.30.60.70.70.6-0.2-0.00.10.80.00.8-0.1-0.1-0.50.80.1
Saline control response1.82.43.6-1.0-1.01.61.6-1.71.8-1.01.9-0.91.81.91.8-1.11.9
Condit. Reinf. active minus inactive responses0.81.02.71.51.60.8-0.30.5-0.41.6-0.31.6-0.4-0.6-0.61.2-0.4
Condit. Reinf. active-inactive response ratio1.61.75.11.82.02.30.2-0.50.62.00.52.00.60.00.21.20.6
Condit. Reinf. active responses0.91.31.91.41.4-0.4-0.61.2-1.21.4-0.91.4-1.2-1.1-0.91.3-1.1
Condit. Reinf. inactive responses0.81.03.3-0.1-0.4-1.8-0.61.3-1.3-0.3-1.2-0.2-1.3-0.9-0.70.2-1.2
Condit. Reinf. lever presses0.81.23.31.61.80.7-0.00.4-0.41.80.11.7-0.4-0.50.21.7-0.1
Condit. Reinf. lever reinforcers received0.60.81.51.11.1-0.3-0.41.0-1.01.1-0.61.1-1.0-0.9-0.51.2-0.8
Pavlov. Cond. lever latency0.70.93.00.60.5-0.8-0.91.0-1.00.5-1.20.6-1.0-1.0-1.70.5-1.5
Pavlov. Cond. magazine entry latency1.41.63.2-1.0-0.70.91.6-1.41.4-1.01.8-0.91.41.61.4-0.41.5
Pavlov. Cond. change in total contacts1.72.45.8-0.4-0.12.01.5-1.81.8-0.31.8-0.31.91.72.4-0.12.3
Pavlov. Cond. index score0.60.81.9-0.3-0.10.91.0-0.90.9-0.21.4-0.31.01.01.20.21.3
Pavlov. Cond. latency score0.70.92.1-0.5-0.20.91.0-1.01.0-0.31.5-0.41.11.11.30.11.3
Pavlov. Cond. lever contacts0.60.82.1-0.4-0.20.81.0-0.90.9-0.31.4-0.41.00.91.5-0.21.3
Pavlov. Cond. magazine entry number0.60.71.80.70.3-0.6-1.40.9-0.90.6-1.20.6-0.9-1.0-0.90.2-0.7
Pavlov. Cond. intertrial magazine entries3.84.98.61.20.8-2.6-2.52.7-2.81.0-2.91.0-2.7-2.6-2.40.8-2.7
Pavlov. Cond. lever-magazine prob. diff.0.81.02.3-0.6-0.30.91.2-1.11.1-0.51.5-0.51.21.21.4-0.01.4
Pavlov. Cond. response bias0.60.82.4-0.6-0.40.61.3-0.80.8-0.51.3-0.60.91.01.6-0.41.1
Conditioned reinforcement - actives0.20.20.80.80.50.2-0.30.4-0.30.6-0.10.50.1-0.1-0.20.90.2
Conditioned reinforcement - inactives0.30.31.40.70.1-0.4-0.20.9-0.80.50.10.3-0.4-0.00.31.20.2
Conditioned locomotion0.20.31.3-0.5-1.2-0.10.1-0.10.2-0.80.6-0.70.40.40.4-0.60.4
Intermittent access intake day 1-15 change0.20.20.90.50.50.60.1-0.10.20.50.30.60.00.30.60.90.6
Intermittent access intake escalation0.10.10.50.00.00.50.4-0.30.30.00.40.10.20.50.70.40.6
Intermittent access intake escalation 20.40.40.90.50.7-0.4-0.50.8-0.80.8-0.30.6-0.7-0.6-0.41.0-0.6
Intermitt. access day 1 inactive lever presses1.51.65.7-1.8-2.4-0.90.8-0.20.2-2.00.7-1.90.31.00.8-1.30.7
Intermitt. access day 15 inactive lever presses0.20.20.6-0.7-0.6-0.80.80.2-0.1-0.50.4-0.8-0.00.4-0.2-0.3-0.3
Intermitt. access escalation Index1.21.12.11.01.5-0.5-0.80.9-0.91.2-0.91.2-0.9-0.9-1.31.3-0.8
Intermittent access day 1 total infusions0.00.00.10.1-0.4-0.1-0.10.2-0.1-0.30.30.00.10.2-0.20.20.2
Intermittent access day 15 total infusions0.30.30.70.60.10.90.3-0.20.40.30.60.60.40.50.50.70.8
Intermittent access terminal intake (last 3 days)0.30.31.10.60.30.70.3-0.00.20.50.80.60.30.50.51.00.7
Intermittent access total infusions0.10.10.2-0.0-0.5-0.10.10.2-0.1-0.30.5-0.10.10.40.40.30.4
Intermittent access day 1 locomotion0.20.21.0-0.3-1.0-0.0-0.0-0.20.3-0.70.4-0.40.30.4-0.3-0.50.4
Intermittent access day 15 total locomotion0.10.10.6-0.2-0.8-0.20.20.10.0-0.50.3-0.30.10.20.1-0.40.0
Intermittent access total locomotion0.40.41.9-0.7-1.4-0.9-0.10.2-0.2-1.20.3-0.9-0.10.30.1-0.60.2
Intermittent access standard deviation0.20.20.80.30.10.80.9-0.20.40.50.60.50.20.40.40.1-0.1
Cocaine induced anxiety0.50.62.6-0.7-0.8-1.6-0.10.9-1.1-0.5-0.4-0.6-0.8-0.5-0.4-0.1-1.0
Post-drug Anxiety0.20.20.7-0.4-0.3-0.80.60.5-0.5-0.30.1-0.4-0.60.00.40.1-0.4
Baseline Anxiety0.50.51.8-0.5-0.40.30.6-0.80.8-0.70.9-0.70.40.81.3-0.21.1
Lifetime Intake0.10.10.20.0-0.3-0.2-0.00.3-0.2-0.20.4-0.00.00.20.30.30.3
Incentive Sensitization - Responses0.40.41.60.40.20.71.3-0.20.30.40.90.70.40.71.00.60.3
Incentive Sensitization - Breakpoint0.40.41.40.50.30.71.2-0.20.30.41.00.70.40.61.00.60.3
Progressive ratio test 1 active lever presses0.10.10.5-0.4-0.7-0.2-0.30.1-0.0-0.50.2-0.50.30.3-0.0-0.10.5
Progressive ratio test 1 breakpoint0.40.41.0-0.8-1.0-0.10.0-0.20.3-0.90.5-0.90.60.60.3-0.50.8
Progressive ratio test 1 inactive lever presses0.30.41.2-0.8-1.0-1.1-0.20.4-0.4-0.80.2-0.8-0.20.2-0.00.00.5
Progressive ratio test 2 active lever presses0.20.20.7-0.1-0.50.30.6-0.10.2-0.30.80.00.50.70.90.10.7
Progressive ratio test 2 breakpoint0.10.10.40.2-0.20.10.20.2-0.1-0.00.40.20.10.40.60.40.5
Progressive ratio test 2 inactive lever presses0.40.52.10.70.2-0.5-0.51.1-0.90.5-0.20.7-0.7-0.4-0.51.4-0.3
Total sessions with >9 infusions0.10.10.30.30.10.2-0.30.10.00.20.10.30.10.10.20.40.5
Short access day 1 total inactive lever presses1.11.24.2-1.3-1.3-2.1-0.60.8-0.9-1.4-0.6-1.5-0.6-0.3-0.8-1.0-0.7
Short access day 10 total inactive lever presses1.51.74.4-1.9-2.1-0.81.1-0.50.5-1.90.9-1.80.41.10.8-1.80.4
Short access day 1 total infusions0.10.20.8-0.4-0.1-0.9-0.60.5-0.5-0.3-0.1-0.4-0.3-0.1-0.10.20.1
Short access day 10 total infusions0.30.31.2-0.2-0.50.00.2-0.20.3-0.40.7-0.40.50.71.00.21.1
Short access total infusions0.10.20.5-0.4-0.6-0.7-0.30.3-0.2-0.60.1-0.6-0.10.10.3-0.20.3
Short access day 1 locomotion0.40.51.0-0.9-0.8-1.0-0.70.3-0.2-0.8-0.7-1.0-0.1-0.10.5-1.00.4
Short access day 10 total locomotion1.41.54.1-1.8-2.0-0.90.9-0.30.4-2.00.8-1.80.40.90.7-1.60.5
Short access total locomotion0.80.82.0-1.1-1.4-0.50.2-0.40.4-1.40.5-1.30.40.80.9-1.11.1
Compulsive drug intake1.31.33.21.10.7-0.7-1.61.0-1.11.0-1.81.1-1.1-1.4-0.90.6-0.8
One hour access (0.3 mA shock)0.81.02.51.10.6-0.6-0.91.5-1.31.0-0.61.1-0.9-0.8-0.51.6-0.4
One hour access (shock baseline)0.40.41.90.70.5-0.20.11.0-0.70.70.30.7-0.4-0.1-0.31.4-0.4
Number of responses in last shaping day0.10.10.60.10.20.2-0.3-0.20.20.10.10.00.20.30.3-0.10.8
Context. condit. distance diff. score0.91.13.1-1.7-1.5-1.40.80.2-0.1-1.60.7-1.70.00.60.9-0.9-0.0
Locomotion velocity, session 11.61.72.5-1.3-1.11.01.3-1.51.6-1.11.5-1.21.41.50.8-1.41.1
Locomotion distance, session 14.05.26.8-1.8-2.01.52.3-2.52.5-2.12.6-2.02.52.62.3-2.32.3
Locomotion velocity, session 24.95.88.3-2.2-1.91.92.8-2.82.9-2.12.7-2.12.82.61.4-2.91.9
Locomotion distance, session 25.07.111.0-1.8-1.72.73.1-3.33.3-1.93.1-1.83.23.12.2-2.72.7
Locomotion velocity, session 30.50.62.20.81.11.51.2-0.50.71.00.51.00.50.2-0.2-0.3-0.4
Locomotion distance, session 30.00.00.30.10.10.10.6-0.10.10.20.40.1-0.00.2-0.1-0.2-0.1
Stereotopy head waving bouts, day 33.23.89.82.83.12.6-0.0-0.00.23.1-0.13.10.0-0.5-1.32.8-0.6
Stereotopy head waving duration, day 32.22.68.42.12.62.90.4-0.70.82.40.22.40.70.1-0.71.9-0.1
Locomotion velocity, session 73.63.95.7-1.9-1.71.52.2-2.32.3-1.71.4-1.72.22.12.2-2.41.8
Locomotion distance, session 70.70.91.6-1.2-0.90.20.6-1.00.8-1.20.5-1.10.80.90.8-1.31.1
Stereotopy head waving bouts, day 71.71.97.00.81.0-0.7-0.51.4-1.31.3-1.61.1-1.4-1.4-1.81.0-2.6
Stereotopy head waving duration, day 72.32.87.21.51.7-0.5-0.81.6-1.51.9-1.81.8-1.6-1.7-1.81.5-2.7
Locomotion velocity, session 82.53.08.5-2.1-1.60.61.9-1.71.7-1.81.2-2.01.81.61.3-2.90.7
Locomotion distance, session 82.43.65.1-2.2-2.10.32.2-1.51.6-2.22.0-2.21.62.02.2-2.31.5
Degree of sensitization distance0.70.71.8-1.2-1.0-0.20.1-0.60.5-1.30.1-1.20.60.61.0-1.01.0
Degree of sensitization stereotypy0.80.84.1-0.9-0.8-1.40.40.8-0.7-0.5-0.7-0.7-0.8-0.5-0.8-0.5-2.0
Condit. Reinf. active minus inactive responses0.10.10.50.20.10.70.2-0.30.40.30.50.30.30.20.1-0.20.1
Condit. Reinf. active-inactive response ratio2.12.33.8-0.8-0.91.91.6-1.81.9-0.81.9-0.81.91.71.4-1.51.5
Condit. Reinf. active responses0.10.10.20.40.30.2-0.10.2-0.10.5-0.10.4-0.1-0.3-0.30.0-0.4
Condit. Reinf. inactive responses1.72.02.91.21.2-1.2-1.51.7-1.71.2-1.61.1-1.6-1.7-1.51.2-1.5
Incentive salience index mean0.50.61.5-0.4-0.41.01.1-0.91.0-0.31.2-0.30.90.80.5-0.70.5
Condit. Reinf. lever presses1.62.23.9-1.0-0.91.62.0-1.71.8-0.81.8-0.81.81.71.2-1.31.3
Time in familiar zone, hab. session 15.35.08.12.12.1-1.0-2.42.0-2.22.1-2.82.2-2.0-2.4-2.92.3-2.3
Time in novel zone, hab. session 14.34.27.2-1.7-1.91.32.1-2.02.1-1.72.5-1.82.02.32.7-1.82.5
Total zone transitions, hab. session 13.54.96.8-2.0-1.81.72.6-2.62.6-2.01.8-2.02.42.52.3-2.61.9
Total locomotion distance, hab. session 12.53.54.9-1.6-1.61.51.8-2.12.1-1.71.4-1.62.12.12.0-2.22.1
Locomotion velocity, hab. session 13.24.67.4-2.1-2.01.42.2-2.32.3-2.21.5-2.12.32.32.3-2.72.1
Time in familiar zone, hab. session 20.30.41.5-0.4-0.4-1.2-0.80.7-0.7-0.4-0.5-0.5-0.7-0.40.10.60.1
Time in novel zone, hab. session 21.41.42.8-0.5-0.41.71.5-1.61.6-0.41.4-0.31.51.30.9-1.30.9
Total zone transitions, hab. session 23.34.36.1-1.6-1.51.72.5-2.32.4-1.62.1-1.72.42.32.1-2.22.1
Total locomotion distance, hab. session 22.02.64.1-1.4-1.31.41.5-1.71.8-1.41.5-1.41.91.81.7-1.72.0
Locomotion velocity, hab. session 22.02.63.7-1.5-1.41.31.6-1.71.7-1.51.5-1.51.81.81.6-1.81.9
Novel to familiar place preference ratio0.50.51.7-0.9-1.3-0.40.2-0.40.3-1.10.3-0.90.40.50.8-0.80.5
Novelty place preference0.50.51.2-0.8-1.10.00.4-0.60.6-0.90.6-0.70.60.70.8-0.70.7
Time in novel zone, NPP test0.70.81.2-0.8-1.10.40.6-0.90.9-0.90.9-0.70.91.01.1-0.71.0
Total zone transitions, NPP test7.310.515.3-2.2-2.23.03.4-3.93.9-2.33.8-2.43.83.83.3-2.93.8
Total locomotion distance, NPP test4.56.29.8-1.5-1.42.82.5-3.03.0-1.42.6-1.53.12.92.6-2.03.1
Locomotion velocity, NPP test3.34.77.5-1.4-1.42.32.2-2.62.6-1.52.2-1.42.62.52.2-2.12.7
Pavlov. Cond. lever latency1.41.74.41.51.5-0.3-1.41.0-1.11.6-1.41.4-1.1-1.3-0.82.1-0.8
Pavlov. Cond. magazine entry latency1.92.54.5-1.6-1.51.02.1-1.61.7-1.51.6-1.41.51.81.3-2.11.1
Pavlov. Cond. change in total contacts0.60.61.2-1.0-1.1-0.10.9-0.50.6-0.90.9-0.90.50.70.5-1.10.3
Pavlov. Cond. index score1.92.45.0-1.8-1.80.51.8-1.21.4-1.81.6-1.71.31.61.3-2.21.0
Pavlov. Cond. latency score2.02.64.7-1.7-1.70.71.8-1.41.5-1.71.8-1.61.51.81.4-2.21.3
Pavlov. Cond. lever contacts1.82.24.3-1.9-1.90.11.5-1.01.1-1.91.5-1.81.11.51.1-2.10.9
Pavlov. Cond. magazine entry number0.91.22.41.31.3-0.2-1.40.8-0.91.3-1.11.2-0.8-1.1-0.61.6-0.4
Pavlov. Cond. intertrial magazine entries3.03.64.62.01.6-1.4-2.12.1-2.11.8-1.61.8-2.1-2.1-2.01.9-1.9
Pavlov. Cond. lever-magazine prob. diff.1.72.25.0-1.8-1.90.21.6-1.11.2-1.81.4-1.71.21.51.0-2.20.8
Pavlov. Cond. response bias0.40.51.8-0.9-1.0-0.01.1-0.30.4-0.90.7-0.80.40.60.1-1.3-0.2
Bone: apparent density0.40.61.30.3-0.1-1.0-0.80.8-0.90.2-1.10.2-1.0-1.0-1.00.2-1.2
Bone surface1.01.83.41.10.8-1.2-1.11.5-1.51.1-1.41.0-1.7-1.6-1.81.0-1.8
Bone volume0.50.91.80.60.4-0.9-0.91.0-1.00.6-1.10.6-1.2-1.1-1.40.6-1.3
Bone: connectivity density0.81.32.80.1-0.2-1.7-1.11.2-1.30.1-1.60.0-1.3-1.3-1.40.0-1.6
Bone: cortical apparent density0.20.20.6-0.7-0.5-0.6-0.4-0.0-0.0-0.8-0.3-0.7-0.1-0.2-0.2-0.5-0.3
Bone: cortical area2.13.36.2-1.9-1.41.22.5-2.02.0-1.61.9-1.61.82.11.9-1.91.3
Bone: cortical porosity2.32.55.2-2.3-2.2-0.51.5-1.11.0-2.21.3-2.31.01.31.2-2.00.7
Bone: cortical porosity3.23.47.4-2.7-2.7-0.91.6-1.01.0-2.71.3-2.71.11.51.5-2.30.7
Bone: cortical thickness1.11.73.4-1.3-0.81.11.9-1.51.5-1.01.1-1.11.31.51.6-1.31.0
Bone: cortical thickness0.30.41.0-1.0-0.8-0.10.4-0.50.5-1.00.5-0.90.40.40.2-0.90.1
Bone: cortical tissue density0.20.20.6-0.7-0.6-0.6-0.4-0.0-0.0-0.8-0.3-0.7-0.1-0.2-0.1-0.5-0.3
Bone: elastic displacement3.43.85.1-1.9-1.81.01.9-2.02.0-1.92.0-1.92.22.22.3-1.82.1
Bone: elastic work1.52.02.8-1.2-1.11.01.6-1.51.5-1.11.5-1.21.61.71.7-1.41.5
Bone: endosteal estimation0.30.61.5-0.3-0.40.91.2-0.91.0-0.41.2-0.30.80.90.3-0.90.5
Bone: endosteal perimeter1.43.05.0-1.6-1.61.02.2-1.81.8-1.62.2-1.51.72.01.6-1.81.4
Bone: final force0.20.41.60.61.01.30.7-0.30.40.80.30.80.20.2-0.10.2-0.1
Bone: final moment0.40.62.80.91.21.70.8-0.60.61.00.51.00.40.30.00.30.1
Bone: marrow area0.40.81.9-0.3-0.51.01.3-1.01.1-0.41.4-0.30.91.00.4-0.90.7
Bone: maximum diameter3.87.010.6-2.7-2.21.73.2-2.92.9-2.42.6-2.42.63.02.7-3.12.1
Bone: maximum force0.10.20.6-0.3-0.10.50.8-0.40.4-0.20.7-0.20.30.50.0-0.40.1
Bone: maximum moment0.20.31.0-0.1-0.00.91.0-0.70.7-0.10.9-0.10.50.70.2-0.40.3
Bone: minimum diameter0.20.31.2-0.4-0.30.51.1-0.60.6-0.30.7-0.30.40.70.4-0.30.0
Bone: periosteal estimation1.22.45.1-1.2-0.91.52.3-1.81.8-1.11.8-1.01.61.81.3-1.71.1
Bone: periosteal perimeter2.64.37.0-2.4-2.10.72.6-2.02.0-2.22.1-2.21.82.32.1-2.41.4
Bone: post-yield work0.40.51.20.90.80.0-0.20.5-0.50.8-0.21.0-0.6-0.7-1.10.7-1.1
Bone: stiffness0.20.41.30.00.3-0.70.10.8-0.70.2-0.00.1-0.9-0.5-1.00.3-1.1
Bone: tissue strength1.61.54.11.91.81.5-0.20.0-0.02.00.01.9-0.1-0.3-0.02.00.4
Bone: trabecular number0.81.23.40.2-0.2-1.5-0.91.1-1.20.1-1.50.0-1.3-1.3-1.60.0-1.9
Bone: trabecular spacing0.20.20.70.40.40.7-0.1-0.20.20.4-0.10.50.40.20.80.40.7
Bone: trabecular thickness0.20.21.0-0.0-0.01.0-0.0-0.80.70.00.20.10.60.4-0.1-0.20.6
Bone: trabecular tissue density1.31.92.9-1.3-1.10.81.0-1.51.5-1.31.6-1.41.51.51.3-1.31.7
Breakpoint value in progressive ratio session1.11.22.9-0.20.2-1.7-0.91.4-1.40.1-1.20.2-1.3-1.1-1.40.3-1.6
Distance traveled before self-admin1.92.02.8-0.9-1.31.11.5-1.61.6-1.31.7-1.31.41.61.4-1.41.7
Distance traveled after self-admin0.20.20.7-0.5-0.70.0-0.0-0.40.4-0.90.3-0.80.30.3-0.3-0.50.4
Delta time in closed arm before/after self-admin0.90.92.1-1.4-1.4-1.30.70.1-0.1-1.40.2-1.3-0.20.20.3-1.2-0.7
Delta time in open arm before/after self-admin0.20.20.9-0.2-0.5-0.4-1.00.2-0.3-0.5-0.9-0.3-0.3-0.4-0.4-0.5-0.0
Diff in mean of infusions in LGA sessions0.70.81.60.80.8-0.4-0.41.1-1.00.9-0.71.2-0.6-0.8-1.20.8-1.3
Extinction: sum of active levers before priming1.41.44.2-2.1-1.8-1.00.5-0.30.2-1.80.6-1.80.40.91.2-1.10.9
Active lever presses in extinction session 60.70.72.5-1.6-1.3-1.20.2-0.0-0.0-1.20.4-1.30.10.40.3-0.70.3
Delta distance traveled before/after self-admin0.80.81.70.10.0-1.3-1.31.0-1.1-0.1-1.30.2-1.0-1.0-1.10.3-1.0
Delta ambulatory time before/after self-admin0.60.71.50.20.2-1.1-1.20.9-0.90.0-1.20.3-1.0-1.0-1.10.3-0.8
Time in closed arm before self-admin1.21.33.81.51.91.7-0.8-0.10.11.9-0.11.60.3-0.3-0.71.40.6
Time in closed arm after self-admin0.20.20.4-0.30.00.60.4-0.40.40.10.6-0.10.70.50.40.10.6
Time in open arm before self-admin0.10.10.30.30.1-0.60.30.3-0.3-0.2-0.10.0-0.4-0.20.30.0-0.5
Time in open arm after self-admin0.91.03.1-0.4-0.7-1.8-1.10.9-0.9-0.9-1.4-0.7-1.1-0.9-0.8-0.6-1.1
Sum of active levers in priming session hrs 5-61.81.83.3-1.8-1.7-0.41.3-0.90.9-1.81.5-1.81.01.41.4-1.01.1
Time to tail flick, vehicle, before self-admin0.30.31.00.60.90.60.00.00.01.0-0.20.9-0.2-0.00.41.00.3
Time to tail flick, vehicle, after self-admin0.70.81.4-0.7-0.70.50.8-1.11.1-0.81.2-0.80.91.10.3-0.31.2
Time to tail flick, test, before self-admin1.31.32.61.61.3-0.0-0.71.2-1.11.4-0.81.6-0.9-1.1-0.81.3-1.1
Time to tail flick, test, after self-admin1.61.75.51.71.62.30.6-0.91.01.70.81.50.90.60.71.31.2
Delta time to tail flick, vehicle, before/after SA0.90.92.0-1.2-1.2-0.20.5-0.90.8-1.31.0-1.40.80.8-0.2-1.20.6
Delta time to tail flick, test, before/after SA1.00.93.40.71.01.80.3-0.90.91.10.60.80.70.70.80.81.5
Ambulatory time before self-admin1.51.62.3-0.6-0.91.21.4-1.41.4-0.91.5-0.91.41.51.4-1.31.5
Ambulatory time after self-admin0.20.20.8-0.3-0.7-0.2-0.2-0.30.2-0.90.2-0.70.10.2-0.3-0.70.3
Total heroin consumption0.20.31.5-0.60.20.40.7-0.10.20.10.90.20.30.5-0.21.20.1
Area under the delay curve0.40.51.10.40.7-0.3-0.40.6-0.80.8-0.70.6-0.7-0.8-0.80.5-1.1
Delay disc. indifference point, 0s delay1.71.83.01.21.2-0.8-1.21.4-1.41.4-1.41.3-1.5-1.6-1.31.3-1.7
Delay disc. indifference point, 16s delay0.20.20.80.30.40.90.8-0.40.30.60.20.60.20.20.3-0.3-0.1
Delay disc. indifference point, 2s delay0.40.41.80.50.71.40.6-0.50.51.00.50.70.60.20.20.40.2
Delay disc. indifference point, 24s delay0.40.41.4-1.2-0.9-1.0-0.20.2-0.4-1.0-0.2-0.9-0.2-0.1-0.0-0.6-0.3
Delay disc. indifference point, 4s delay2.72.95.01.62.2-0.6-1.21.7-1.72.0-1.81.6-1.8-1.9-1.71.4-1.9
Delay disc. indifference point, 8s delay0.20.20.60.00.1-0.8-0.40.6-0.8-0.0-0.40.0-0.6-0.5-0.40.4-0.7
Delay discount exponential model param0.40.51.0-0.3-0.70.30.5-0.70.9-0.70.7-0.50.70.80.8-0.41.0
Delay discount hyperbolic model param0.40.40.9-0.4-0.80.20.4-0.60.8-0.90.6-0.60.60.80.8-0.50.9
Fecal boli incidents, locomotor time 10.80.92.3-0.0-0.31.41.0-1.21.20.20.80.11.30.91.5-0.51.2
Change in fecal boli incidents, locomotor task0.60.51.1-0.4-0.50.80.3-0.70.8-1.00.7-0.60.80.80.4-1.01.0
Time >=10cm from walls, locomotor time 10.60.61.6-1.3-0.5-0.50.9-0.40.3-1.21.0-1.20.50.80.3-0.80.4
Bouts of movement, locomotor time 10.50.62.00.91.40.2-0.20.3-0.31.4-0.01.1-0.3-0.4-0.61.0-0.3
Total resting periods, locomotor time 10.40.51.60.81.30.70.00.00.01.30.31.0-0.0-0.2-0.40.9-0.1
Rest time, locomotor task time 11.82.04.4-1.2-0.90.92.1-1.61.6-0.81.9-1.01.51.71.7-1.01.0
Distance moved, locomotor task time 10.40.41.20.60.3-0.2-1.10.7-0.70.4-1.00.4-0.6-0.8-0.8-0.0-0.5
Vertical activity count, locomotor time 10.91.01.90.50.3-1.2-1.21.4-1.40.1-1.20.1-1.3-1.2-0.80.0-1.1
Time >=10cm from walls, locomotor time 20.20.31.3-0.50.1-0.80.30.1-0.1-0.3-0.1-0.5-0.3-0.3-0.8-0.5-1.1
Bouts of movement, locomotor time 20.50.51.5-0.8-0.70.20.7-0.50.5-0.70.7-0.80.60.91.2-0.50.8
Total resting periods, locomotor time 20.50.51.4-0.8-0.50.30.7-0.50.5-0.60.9-0.70.61.01.2-0.30.9
Rest time, locomotor task time 20.10.10.4-0.5-0.2-0.40.3-0.20.1-0.30.4-0.40.10.30.7-0.20.5
Distance moved, locomotor task time 20.60.72.40.80.5-0.2-0.70.7-0.60.8-0.90.8-0.7-1.1-1.50.1-1.6
Vertical activity count, locomotor time 20.50.51.60.1-0.5-1.0-0.50.8-0.7-0.2-0.8-0.2-0.9-0.8-0.8-0.1-1.3
Weight adjusted by age2.22.55.1-0.1-0.32.21.6-2.02.0-0.31.7-0.52.12.01.6-0.12.3
Seeking ratio, delayed vs. immediate footshock1.61.85.0-1.7-2.1-1.80.10.4-0.5-2.2-0.7-1.9-0.5-0.10.4-2.1-1.0
Locomotion in novel chamber1.31.63.21.10.9-0.7-1.31.1-1.11.2-1.71.4-1.3-1.7-1.40.3-1.8
Locomotion in novel chamber post-restriction1.31.63.51.21.5-0.3-1.41.1-1.11.6-1.01.3-1.3-1.3-1.01.9-0.8
Progressive ratio2.02.34.6-0.7-1.01.61.8-2.12.1-0.91.6-1.11.61.61.4-1.81.4
Food seeking constrained by brief footshock0.30.41.5-1.0-0.5-0.20.8-0.30.3-0.70.3-0.80.40.3-0.2-1.2-0.5
Seeking ratio, punishment vs. effort0.81.02.5-0.00.6-1.3-0.71.5-1.60.5-0.90.5-0.9-1.1-1.20.8-1.4
Run reversals in cocaine runway, females0.20.21.00.41.00.3-0.6-0.30.30.6-0.40.30.3-0.2-0.5-0.00.2
Run reversals in cocaine runway, males0.40.41.8-0.2-0.30.61.3-0.60.7-0.41.1-0.20.60.90.10.10.2
Latency to leave start box in cocaine runway2.62.85.01.00.7-1.9-1.52.2-2.20.8-1.80.9-2.0-1.9-1.91.2-2.1
Latency to leave start box in cocaine runway, F1.31.52.51.10.8-0.7-1.41.4-1.40.9-1.40.8-1.3-1.3-1.31.6-1.1
Latency to leave start box in cocaine runway, M2.42.36.00.60.6-2.0-0.91.9-1.90.6-1.60.9-1.7-1.7-1.90.1-2.5
Cd content in liver0.10.21.0-0.10.2-0.40.30.2-0.20.2-0.1-0.1-0.4-0.3-0.7-0.1-1.0
Co content in liver0.81.02.4-1.5-1.4-0.50.8-0.60.5-1.50.6-1.50.60.60.5-1.50.0
Cu content in liver1.92.33.11.71.7-0.3-0.81.6-1.51.8-1.11.7-1.4-1.5-1.71.8-1.6
Fe content in liver1.11.33.61.51.60.2-0.61.0-0.91.7-0.51.6-0.9-0.9-0.61.9-0.6
K content in liver0.10.10.7-0.0-0.20.40.3-0.40.4-0.10.2-0.20.50.30.1-0.80.2
Mg content in liver0.10.10.5-0.2-0.40.20.4-0.30.3-0.40.4-0.40.40.30.1-0.70.2
Mn content in liver1.61.82.8-1.3-1.30.61.7-1.51.4-1.31.4-1.41.51.51.3-1.50.9
Na content in liver0.10.10.20.40.2-0.3-0.40.3-0.30.1-0.40.1-0.3-0.4-0.4-0.2-0.2
Rb content in liver0.20.30.90.60.70.6-0.20.2-0.20.80.00.7-0.2-0.10.11.00.3
Se content in liver0.91.11.81.10.7-0.9-1.11.3-1.30.9-1.20.8-1.3-1.2-1.10.9-1.0
Sr content in liver0.60.61.41.01.20.1-0.50.5-0.50.9-0.70.9-0.5-0.8-0.80.7-0.7
Zn content in liver0.00.00.10.1-0.1-0.2-0.20.3-0.4-0.20.30.1-0.2-0.10.20.10.3