chr3:126,160,536-128,707,024

Trait: Body weight

Best TWAS P=6.71e-13 · Best GWAS P=2.20e-12 conditioned to NaN

Associated models

Tissue Gene RNA modality RNA phenotype h2 # weights Model R2 Model R2 P TWAS Z TWAS P Coloc P Joint
Adipose Macrod2 alternative TSS XM_039106857.1 0.1 84 0.06 3.0e-07 5.97 2.40e-09 0.3 FALSE
Adipose Macrod2 alternative TSS XM_039106861.1 0.12 1 0.08 7.9e-09 -5.67 1.41e-08 0.02 FALSE
Adipose Tasp1 alternative TSS XM_039105024.1 0.03 4 0.02 1.6e-03 6.69 2.23e-11 0.44 FALSE
Adipose Tasp1 alternative TSS XM_039105025.1 0.06 1686 0.05 1.8e-06 6.58 4.73e-11 0.52 FALSE
Adipose Tasp1 alternative TSS XM_039105026.1 0.04 1686 0.02 1.3e-03 -6.57 5.09e-11 0.42 FALSE
Adipose Tasp1 alternative TSS XM_039105024.1 0.03 39 0.01 7.6e-03 6.59 4.49e-11 0.36 TRUE
Adipose Tasp1 alternative TSS XM_039105025.1 0.07 1686 0.06 5.2e-07 6.58 4.79e-11 0.53 FALSE
Adipose Tasp1 alternative TSS XM_039105026.1 0.03 1686 0.01 1.6e-02 -6.59 4.53e-11 0.33 FALSE
Adipose Macrod2 gene expression Macrod2 0.49 1 0.35 3.7e-40 -6.69 2.29e-11 0.92 FALSE
Adipose Esf1 mRNA stability Esf1 0.18 102 0.08 3.3e-09 -5.3 1.17e-07 0 FALSE
Adipose Macrod2 mRNA stability Macrod2 0.44 457 0.29 2.0e-32 -6.38 1.74e-10 0.57 FALSE
Adipose Ndufaf5 mRNA stability Ndufaf5 0.04 1668 0.03 5.7e-04 6.06 1.39e-09 0.51 FALSE
BLA Flrt3 gene expression Flrt3 0.06 1 0.05 1.2e-03 5.77 7.91e-09 0.04 FALSE
BLA Macrod2 gene expression Macrod2 0.12 29 0.08 5.5e-05 6.5 7.99e-11 0.63 FALSE
BLA Macrod2 intron excision ratio chr3_127725722_127779334 0.06 1 0.03 1.5e-02 -6.47 1.00e-10 0.04 FALSE
BLA Macrod2 mRNA stability Macrod2 0.14 1 0.09 1.6e-05 -6.15 7.95e-10 0.12 FALSE
BLA Tasp1 mRNA stability Tasp1 0.08 1 0.07 1.5e-04 5.76 8.38e-09 0.05 FALSE
Brain Ism1 gene expression Ism1 0.11 1710 0.12 3.7e-11 -5.63 1.75e-08 0.58 FALSE
Brain LOC102548513 gene expression LOC102548513 0.04 2054 0.03 4.6e-04 -6.65 2.99e-11 0.26 FALSE
Brain Sptlc3 gene expression Sptlc3 0.06 1712 0.03 4.9e-04 -6.08 1.17e-09 0.49 FALSE
Brain Macrod2 mRNA stability Macrod2 0.07 277 0.09 6.2e-09 -5.86 4.76e-09 0.57 FALSE
Brain Ndufaf5 mRNA stability Ndufaf5 0.07 3 0.04 3.3e-04 5.18 2.18e-07 0.11 FALSE
IL LOC102548513 gene expression LOC102548513 0.33 2054 0.17 5.5e-05 -6.22 5.09e-10 0.47 FALSE
IL Macrod2 mRNA stability Macrod2 0.14 1 0.12 9.3e-04 -5.73 9.77e-09 0.05 FALSE
IL Tasp1 mRNA stability Tasp1 0.11 1687 0.05 2.8e-02 -5.84 5.10e-09 0.36 FALSE
LHb Ism1 gene expression Ism1 0.51 1710 0.45 4.1e-12 -5.26 1.43e-07 0.08 FALSE
LHb LOC102548513 gene expression LOC102548513 0.17 1 0.16 1.1e-04 5.97 2.33e-09 0.05 FALSE
LHb Tasp1 mRNA stability Tasp1 0.18 1 0.12 1.0e-03 5.64 1.68e-08 0.05 FALSE
Liver Flrt3 gene expression Flrt3 0.08 1 0.01 9.0e-03 5.68 1.36e-08 0.03 FALSE
Liver Ism1 gene expression Ism1 0.05 1709 0.01 2.0e-02 5.48 4.29e-08 0.5 FALSE
Liver Esf1 isoform ratio XM_006235105.4 0.15 1668 0.07 1.3e-08 -5.94 2.89e-09 0 FALSE
NAcc Esf1 gene expression Esf1 0.46 1669 0.33 3.6e-39 -5.55 2.86e-08 0 TRUE
NAcc Flrt3 gene expression Flrt3 0.1 38 0.05 4.2e-06 5.56 2.74e-08 0.81 FALSE
NAcc Ndufaf5 gene expression Ndufaf5 0.02 1669 0 9.7e-02 6.54 6.05e-11 0.31 FALSE
NAcc Tasp1 isoform ratio XM_039105026.1 0.03 31 0.03 8.0e-05 5.92 3.21e-09 0.34 FALSE
NAcc Tasp1 isoform ratio XM_039105027.1 0.04 1 0.05 1.6e-06 -5.66 1.53e-08 0.29 FALSE
NAcc Macrod2 intron excision ratio chr3_127725722_127747858 0.05 8 0.03 4.5e-04 -7.19 6.71e-13 0.6 TRUE
NAcc Macrod2 intron excision ratio chr3_127725722_127779334 0.05 8 0.03 5.0e-04 7.13 1.02e-12 0.58 FALSE
NAcc Tasp1 intron excision ratio chr3_127385117_127390780 0.04 1687 0 9.9e-02 5.32 1.01e-07 0.2 FALSE
NAcc Tasp1 intron excision ratio chr3_127385117_127399392 0.04 1687 0.04 1.2e-05 -6.44 1.22e-10 0.43 FALSE
NAcc Ndufaf5 mRNA stability Ndufaf5 0.1 1669 0.1 3.5e-11 5.28 1.26e-07 0.04 FALSE
OFC Ism1 gene expression Ism1 0.27 1710 0.14 2.8e-04 -5.26 1.47e-07 0.48 FALSE
OFC LOC102548513 gene expression LOC102548513 0.14 1 0.05 2.3e-02 5.72 1.04e-08 0.05 TRUE
OFC Tasp1 mRNA stability Tasp1 0.21 12 0.1 2.5e-03 5.63 1.83e-08 0.43 FALSE
PL Ndufaf5 alternative TSS XM_039104593.1 0.29 55 0.22 1.7e-23 5.2 2.03e-07 0 FALSE
PL Ism1 gene expression Ism1 0.02 1 0.02 5.5e-03 5.55 2.93e-08 0.04 FALSE
PL Macrod2 gene expression Macrod2 0.05 1 0.05 2.1e-06 -5.59 2.22e-08 0.02 FALSE
PL Ndufaf5 gene expression Ndufaf5 0.04 1669 0.02 4.7e-03 6.7 2.13e-11 0.52 FALSE
PL Tasp1 gene expression Tasp1 0.03 1687 0.01 1.0e-02 -5.77 7.86e-09 0.21 FALSE
PL Ndufaf5 isoform ratio XM_039104593.1 0.26 56 0.19 4.2e-20 5.89 3.76e-09 0 FALSE
PL Tasp1 isoform ratio XM_039105026.1 0.04 1 0.05 8.5e-06 5.75 9.09e-09 0.21 FALSE
PL Macrod2 intron excision ratio chr3_127725722_127747858 0.06 1830 0.08 5.8e-09 -6.42 1.33e-10 0.21 FALSE
PL Macrod2 intron excision ratio chr3_127725722_127779334 0.06 1830 0.08 5.3e-09 6.41 1.41e-10 0.19 FALSE
PL Tasp1 intron excision ratio chr3_127385117_127399392 0.02 1 0.03 9.1e-04 5.55 2.88e-08 0.03 FALSE
PL Macrod2 mRNA stability Macrod2 0.07 1 0.09 2.0e-10 -6.15 7.95e-10 0.26 FALSE
PL Ndufaf5 mRNA stability Ndufaf5 0.13 31 0.11 1.3e-11 -6.13 8.66e-10 0.12 FALSE
PL Tasp1 mRNA stability Tasp1 0.05 1 0.04 3.6e-05 5.18 2.19e-07 0.03 FALSE
pVTA Esf1 gene expression Esf1 0.51 1669 0.44 4.2e-21 -5.39 7.14e-08 0 FALSE
pVTA Flrt3 gene expression Flrt3 0.1 1 0.09 7.1e-05 7.02 2.29e-12 0.33 FALSE
pVTA Ism1 gene expression Ism1 0.08 1710 0.05 2.4e-03 -5.38 7.29e-08 0.59 FALSE
pVTA Ndufaf5 isoform ratio NM_001126371.1 0.28 1669 0.14 1.2e-06 5.2 2.05e-07 0.01 FALSE
pVTA Macrod2 mRNA stability Macrod2 0.1 1 0.09 7.3e-05 -5.75 9.05e-09 0.04 FALSE