Best TWAS P=6.71e-13 · Best GWAS P=2.20e-12 conditioned to NaN
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Macrod2 | alternative TSS | XM_039106857.1 | 0.1 | 84 | 0.06 | 3.0e-07 | 5.97 | 2.40e-09 | 0.3 | FALSE |
| Adipose | Macrod2 | alternative TSS | XM_039106861.1 | 0.12 | 1 | 0.08 | 7.9e-09 | -5.67 | 1.41e-08 | 0.02 | FALSE |
| Adipose | Tasp1 | alternative TSS | XM_039105024.1 | 0.03 | 4 | 0.02 | 1.6e-03 | 6.69 | 2.23e-11 | 0.44 | FALSE |
| Adipose | Tasp1 | alternative TSS | XM_039105025.1 | 0.06 | 1686 | 0.05 | 1.8e-06 | 6.58 | 4.73e-11 | 0.52 | FALSE |
| Adipose | Tasp1 | alternative TSS | XM_039105026.1 | 0.04 | 1686 | 0.02 | 1.3e-03 | -6.57 | 5.09e-11 | 0.42 | FALSE |
| Adipose | Tasp1 | alternative TSS | XM_039105024.1 | 0.03 | 39 | 0.01 | 7.6e-03 | 6.59 | 4.49e-11 | 0.36 | TRUE |
| Adipose | Tasp1 | alternative TSS | XM_039105025.1 | 0.07 | 1686 | 0.06 | 5.2e-07 | 6.58 | 4.79e-11 | 0.53 | FALSE |
| Adipose | Tasp1 | alternative TSS | XM_039105026.1 | 0.03 | 1686 | 0.01 | 1.6e-02 | -6.59 | 4.53e-11 | 0.33 | FALSE |
| Adipose | Macrod2 | gene expression | Macrod2 | 0.49 | 1 | 0.35 | 3.7e-40 | -6.69 | 2.29e-11 | 0.92 | FALSE |
| Adipose | Esf1 | mRNA stability | Esf1 | 0.18 | 102 | 0.08 | 3.3e-09 | -5.3 | 1.17e-07 | 0 | FALSE |
| Adipose | Macrod2 | mRNA stability | Macrod2 | 0.44 | 457 | 0.29 | 2.0e-32 | -6.38 | 1.74e-10 | 0.57 | FALSE |
| Adipose | Ndufaf5 | mRNA stability | Ndufaf5 | 0.04 | 1668 | 0.03 | 5.7e-04 | 6.06 | 1.39e-09 | 0.51 | FALSE |
| BLA | Flrt3 | gene expression | Flrt3 | 0.06 | 1 | 0.05 | 1.2e-03 | 5.77 | 7.91e-09 | 0.04 | FALSE |
| BLA | Macrod2 | gene expression | Macrod2 | 0.12 | 29 | 0.08 | 5.5e-05 | 6.5 | 7.99e-11 | 0.63 | FALSE |
| BLA | Macrod2 | intron excision ratio | chr3_127725722_127779334 | 0.06 | 1 | 0.03 | 1.5e-02 | -6.47 | 1.00e-10 | 0.04 | FALSE |
| BLA | Macrod2 | mRNA stability | Macrod2 | 0.14 | 1 | 0.09 | 1.6e-05 | -6.15 | 7.95e-10 | 0.12 | FALSE |
| BLA | Tasp1 | mRNA stability | Tasp1 | 0.08 | 1 | 0.07 | 1.5e-04 | 5.76 | 8.38e-09 | 0.05 | FALSE |
| Brain | Ism1 | gene expression | Ism1 | 0.11 | 1710 | 0.12 | 3.7e-11 | -5.63 | 1.75e-08 | 0.58 | FALSE |
| Brain | LOC102548513 | gene expression | LOC102548513 | 0.04 | 2054 | 0.03 | 4.6e-04 | -6.65 | 2.99e-11 | 0.26 | FALSE |
| Brain | Sptlc3 | gene expression | Sptlc3 | 0.06 | 1712 | 0.03 | 4.9e-04 | -6.08 | 1.17e-09 | 0.49 | FALSE |
| Brain | Macrod2 | mRNA stability | Macrod2 | 0.07 | 277 | 0.09 | 6.2e-09 | -5.86 | 4.76e-09 | 0.57 | FALSE |
| Brain | Ndufaf5 | mRNA stability | Ndufaf5 | 0.07 | 3 | 0.04 | 3.3e-04 | 5.18 | 2.18e-07 | 0.11 | FALSE |
| IL | LOC102548513 | gene expression | LOC102548513 | 0.33 | 2054 | 0.17 | 5.5e-05 | -6.22 | 5.09e-10 | 0.47 | FALSE |
| IL | Macrod2 | mRNA stability | Macrod2 | 0.14 | 1 | 0.12 | 9.3e-04 | -5.73 | 9.77e-09 | 0.05 | FALSE |
| IL | Tasp1 | mRNA stability | Tasp1 | 0.11 | 1687 | 0.05 | 2.8e-02 | -5.84 | 5.10e-09 | 0.36 | FALSE |
| LHb | Ism1 | gene expression | Ism1 | 0.51 | 1710 | 0.45 | 4.1e-12 | -5.26 | 1.43e-07 | 0.08 | FALSE |
| LHb | LOC102548513 | gene expression | LOC102548513 | 0.17 | 1 | 0.16 | 1.1e-04 | 5.97 | 2.33e-09 | 0.05 | FALSE |
| LHb | Tasp1 | mRNA stability | Tasp1 | 0.18 | 1 | 0.12 | 1.0e-03 | 5.64 | 1.68e-08 | 0.05 | FALSE |
| Liver | Flrt3 | gene expression | Flrt3 | 0.08 | 1 | 0.01 | 9.0e-03 | 5.68 | 1.36e-08 | 0.03 | FALSE |
| Liver | Ism1 | gene expression | Ism1 | 0.05 | 1709 | 0.01 | 2.0e-02 | 5.48 | 4.29e-08 | 0.5 | FALSE |
| Liver | Esf1 | isoform ratio | XM_006235105.4 | 0.15 | 1668 | 0.07 | 1.3e-08 | -5.94 | 2.89e-09 | 0 | FALSE |
| NAcc | Esf1 | gene expression | Esf1 | 0.46 | 1669 | 0.33 | 3.6e-39 | -5.55 | 2.86e-08 | 0 | TRUE |
| NAcc | Flrt3 | gene expression | Flrt3 | 0.1 | 38 | 0.05 | 4.2e-06 | 5.56 | 2.74e-08 | 0.81 | FALSE |
| NAcc | Ndufaf5 | gene expression | Ndufaf5 | 0.02 | 1669 | 0 | 9.7e-02 | 6.54 | 6.05e-11 | 0.31 | FALSE |
| NAcc | Tasp1 | isoform ratio | XM_039105026.1 | 0.03 | 31 | 0.03 | 8.0e-05 | 5.92 | 3.21e-09 | 0.34 | FALSE |
| NAcc | Tasp1 | isoform ratio | XM_039105027.1 | 0.04 | 1 | 0.05 | 1.6e-06 | -5.66 | 1.53e-08 | 0.29 | FALSE |
| NAcc | Macrod2 | intron excision ratio | chr3_127725722_127747858 | 0.05 | 8 | 0.03 | 4.5e-04 | -7.19 | 6.71e-13 | 0.6 | TRUE |
| NAcc | Macrod2 | intron excision ratio | chr3_127725722_127779334 | 0.05 | 8 | 0.03 | 5.0e-04 | 7.13 | 1.02e-12 | 0.58 | FALSE |
| NAcc | Tasp1 | intron excision ratio | chr3_127385117_127390780 | 0.04 | 1687 | 0 | 9.9e-02 | 5.32 | 1.01e-07 | 0.2 | FALSE |
| NAcc | Tasp1 | intron excision ratio | chr3_127385117_127399392 | 0.04 | 1687 | 0.04 | 1.2e-05 | -6.44 | 1.22e-10 | 0.43 | FALSE |
| NAcc | Ndufaf5 | mRNA stability | Ndufaf5 | 0.1 | 1669 | 0.1 | 3.5e-11 | 5.28 | 1.26e-07 | 0.04 | FALSE |
| OFC | Ism1 | gene expression | Ism1 | 0.27 | 1710 | 0.14 | 2.8e-04 | -5.26 | 1.47e-07 | 0.48 | FALSE |
| OFC | LOC102548513 | gene expression | LOC102548513 | 0.14 | 1 | 0.05 | 2.3e-02 | 5.72 | 1.04e-08 | 0.05 | TRUE |
| OFC | Tasp1 | mRNA stability | Tasp1 | 0.21 | 12 | 0.1 | 2.5e-03 | 5.63 | 1.83e-08 | 0.43 | FALSE |
| PL | Ndufaf5 | alternative TSS | XM_039104593.1 | 0.29 | 55 | 0.22 | 1.7e-23 | 5.2 | 2.03e-07 | 0 | FALSE |
| PL | Ism1 | gene expression | Ism1 | 0.02 | 1 | 0.02 | 5.5e-03 | 5.55 | 2.93e-08 | 0.04 | FALSE |
| PL | Macrod2 | gene expression | Macrod2 | 0.05 | 1 | 0.05 | 2.1e-06 | -5.59 | 2.22e-08 | 0.02 | FALSE |
| PL | Ndufaf5 | gene expression | Ndufaf5 | 0.04 | 1669 | 0.02 | 4.7e-03 | 6.7 | 2.13e-11 | 0.52 | FALSE |
| PL | Tasp1 | gene expression | Tasp1 | 0.03 | 1687 | 0.01 | 1.0e-02 | -5.77 | 7.86e-09 | 0.21 | FALSE |
| PL | Ndufaf5 | isoform ratio | XM_039104593.1 | 0.26 | 56 | 0.19 | 4.2e-20 | 5.89 | 3.76e-09 | 0 | FALSE |
| PL | Tasp1 | isoform ratio | XM_039105026.1 | 0.04 | 1 | 0.05 | 8.5e-06 | 5.75 | 9.09e-09 | 0.21 | FALSE |
| PL | Macrod2 | intron excision ratio | chr3_127725722_127747858 | 0.06 | 1830 | 0.08 | 5.8e-09 | -6.42 | 1.33e-10 | 0.21 | FALSE |
| PL | Macrod2 | intron excision ratio | chr3_127725722_127779334 | 0.06 | 1830 | 0.08 | 5.3e-09 | 6.41 | 1.41e-10 | 0.19 | FALSE |
| PL | Tasp1 | intron excision ratio | chr3_127385117_127399392 | 0.02 | 1 | 0.03 | 9.1e-04 | 5.55 | 2.88e-08 | 0.03 | FALSE |
| PL | Macrod2 | mRNA stability | Macrod2 | 0.07 | 1 | 0.09 | 2.0e-10 | -6.15 | 7.95e-10 | 0.26 | FALSE |
| PL | Ndufaf5 | mRNA stability | Ndufaf5 | 0.13 | 31 | 0.11 | 1.3e-11 | -6.13 | 8.66e-10 | 0.12 | FALSE |
| PL | Tasp1 | mRNA stability | Tasp1 | 0.05 | 1 | 0.04 | 3.6e-05 | 5.18 | 2.19e-07 | 0.03 | FALSE |
| pVTA | Esf1 | gene expression | Esf1 | 0.51 | 1669 | 0.44 | 4.2e-21 | -5.39 | 7.14e-08 | 0 | FALSE |
| pVTA | Flrt3 | gene expression | Flrt3 | 0.1 | 1 | 0.09 | 7.1e-05 | 7.02 | 2.29e-12 | 0.33 | FALSE |
| pVTA | Ism1 | gene expression | Ism1 | 0.08 | 1710 | 0.05 | 2.4e-03 | -5.38 | 7.29e-08 | 0.59 | FALSE |
| pVTA | Ndufaf5 | isoform ratio | NM_001126371.1 | 0.28 | 1669 | 0.14 | 1.2e-06 | 5.2 | 2.05e-07 | 0.01 | FALSE |
| pVTA | Macrod2 | mRNA stability | Macrod2 | 0.1 | 1 | 0.09 | 7.3e-05 | -5.75 | 9.05e-09 | 0.04 | FALSE |